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2. Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu

Author

Takano, Yoshinori, Naraoka, Hiroshi, Dworkin, Jason P., Koga, Toshiki, Sasaki, Kazunori, Sato, Hajime, Oba, Yasuhiro, Ogawa, Nanako O., Yoshimura, Toshihiro, Hamase, Kenji, Ohkouchi, Naohiko, Parker, Eric T., Aponte, José C., Glavin, Daniel P., Furukawa, Yoshihiro, Aoki, Junken, Kano, Kuniyuki, Nomura, Shin-ichiro M., Orthous-Daunay, Francois-Regis, Schmitt-Kopplin, Philippe, Yurimoto, Hisayoshi, Nakamura, Tomoki, Noguchi, Takaaki, Okazaki, Ryuji, Yabuta, Hikaru, Sakamoto, Kanako, Yada, Toru, Nishimura, Masahiro, Nakato, Aiko, Miyazaki, Akiko, Yogata, Kasumi, Abe, Masanao, Okada, Tatsuaki, Usui, Tomohiro, Yoshikawa, Makoto, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Nakazawa, Satoru, Watanabe, Sei-ichiro, Tsuda, Yuichi, and Tachibana, Shogo

Published
2024
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5. Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts

Author

Taketomi, Yoshitaka, Higashi, Takayoshi, Kano, Kuniyuki, Miki, Yoshimi, Mochizuki, Chika, Toyoshima, Shota, Okayama, Yoshimichi, Nishito, Yasumasa, Nakae, Susumu, Tanaka, Satoshi, Tokuoka, Suzumi M., Oda, Yoshiya, Shichino, Shigeyuki, Ueha, Satoshi, Matsushima, Kouji, Akahoshi, Noriyuki, Ishii, Satoshi, Chun, Jerold, Aoki, Junken, and Murakami, Makoto

Published
2024
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8. Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34

Author

Sugihara, Ryuta, Taneike, Manabu, Murakawa, Tomokazu, Tamai, Takahito, Ueda, Hiromichi, Kitazume-Taneike, Rika, Oka, Takafumi, Akazawa, Yasuhiro, Nishida, Hiroki, Mine, Kentaro, Hioki, Ayana, Omi, Jumpei, Omiya, Shigemiki, Aoki, Junken, Ikeda, Kazutaka, Nishida, Kazuhiko, Arita, Makoto, Yamaguchi, Osamu, Sakata, Yasushi, and Otsu, Kinya

Published
2023
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11. Enantioselective three-dimensional high-performance liquid chromatographic determination of amino acids in the Hayabusa2 returned samples from the asteroid Ryugu

Author

Furusho, Aogu, Ishii, Chiharu, Akita, Takeyuki, Oyaide, Mai, Mita, Masashi, Naraoka, Hiroshi, Takano, Yoshinori, Dworkin, Jason P., Oba, Yasuhiro, Koga, Toshiki, Fukushima, Kazuhiko, Aoki, Dan, Hashiguchi, Minako, Mita, Hajime, Chikaraishi, Yoshito, Ohkouchi, Naohiko, Ogawa, Nanako O., Sakai, Saburo, Glavin, Daniel P., Elsila, Jamie E., Parker, Eric T., Aponte, José C., McLain, Hannah L., Orthous-Daunay, Francois-Regis, Vuitton, Véronique, Thissen, Roland, Wolters, Cédric, Schmitt-Kopplin, Philippe, Ruf, Alexander, Isa, Junko, Hertkorn, Norbert, Eiler, John M., Yoshimura, Toshihiro, Sugahara, Haruna, Graham, Heather V., Furukawa, Yoshihiro, Araoka, Daisuke, Tanaka, Satoru, Yoshikawa, Takaaki, Kabashima, Fumie, Sasaki, Kazunori, Sato, Hajime, Yamazaki, Tomoya, Onose, Morihiko, Morita, Mayu, Kimura, Yuki, Kano, Kuniyuki, Aoki, Junken, Fujishima, Kosuke, Nomura, Shin-ichiro, Tachibana, Shogo, Nakamura, Tomoki, Noguchi, Takaaki, Okazaki, Ryuji, Yabuta, Hikaru, Yurimoto, Hisayoshi, Sakamoto, Kanako, Yada, Toru, Nishimura, Masahiro, Nakato, Aiko, Miyazaki, Akiko, Yogata, Kasumi, Abe, Masanao, Usui, Tomohiro, Yoshikawa, Makoto, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Nakazawa, Satoru, Okada, Tatsuaki, Watanabe, Sei-ichiro, Tsuda, Yuichi, and Hamase, Kenji

Published
2024
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13. Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

Author

Liebisch, Gerhard, Fahy, Eoin, Aoki, Junken, Dennis, Edward A, Durand, Thierry, Ejsing, Christer S, Fedorova, Maria, Feussner, Ivo, Griffiths, William J, Köfeler, Harald, Merrill, Alfred H, Murphy, Robert C, O’Donnell, Valerie B, Oskolkova, Olga, Subramaniam, Shankar, Wakelam, Michael JO, and Spener, Friedrich

Subjects
Rare Diseases, Lipids, Mass Spectrometry, Terminology as Topic, mass spectrometry, lipidomics, fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology
Abstract

A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its major changes, i.e., annotation of ring double bond equivalents and number of oxygens, the updated shorthand notation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reporting in lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolution powers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalian phyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stable isotope-labeled compounds in metabolic labeling experiments or as internal standards. This update on lipid classification, nomenclature, and shorthand annotation for lipid mass spectra is considered a standard for lipid data presentation.

Published
2020

17. Metabolic Dysregulation of the Lysophospholipid/autotaxin Axis in the Chromosome 9p21 Gene SNP rs10757274

Author

Meckelmann, Sven W, Hawksworth, Jade I, White, Daniel, Andrews, Robert, Rodrigues, Patricia, O'Connor, Anne, Alvarez-Jarreta, Jorge, Tyrrell, Victoria J, Hinz, Christine, Zhou, You, Williams, Julie, Aldrovandi, Maceler, Watkins, William J, Engler, Adam J, Sardo, Valentina Lo, Slatter, David A, Allen, Stuart M, Acharya, Jay, Mitchell, Jacquie, Cooper, Jackie, Aoki, Junken, Kano, Kuniyuki, Humphries, Steve E, and O'Donnell, Valerie B

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Genetics, Cardiovascular, Heart Disease, Biotechnology, Clinical Research, Heart Disease - Coronary Heart Disease, Aetiology, 2.1 Biological and endogenous factors, Chromosomes, Human, Pair 9, Coronary Disease, HEK293 Cells, Humans, Lysophospholipids, Male, Middle Aged, Phosphoric Diester Hydrolases, Polymorphism, Single Nucleotide, atherosclerosis, lipids, mass spectrometry, phenotype, phospholipids, Medical Biotechnology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundCommon chromosome 9p21 single nucleotide polymorphisms (SNPs) increase coronary heart disease risk, independent of traditional lipid risk factors. However, lipids comprise large numbers of structurally related molecules not measured in traditional risk measurements, and many have inflammatory bioactivities. Here, we applied lipidomic and genomic approaches to 3 model systems to characterize lipid metabolic changes in common Chr9p21 SNPs, which confer ≈30% elevated coronary heart disease risk associated with altered expression of ANRIL, a long ncRNA.MethodsUntargeted and targeted lipidomics was applied to plasma from NPHSII (Northwick Park Heart Study II) homozygotes for AA or GG in rs10757274, followed by correlation and network analysis. To identify candidate genes, transcriptomic data from shRNA downregulation of ANRIL in HEK-293 cells was mined. Transcriptional data from vascular smooth muscle cells differentiated from induced pluripotent stem cells of individuals with/without Chr9p21 risk, nonrisk alleles, and corresponding knockout isogenic lines were next examined. Last, an in-silico analysis of miRNAs was conducted to identify how ANRIL might control lysoPL (lysophosphospholipid)/lysoPA (lysophosphatidic acid) genes.ResultsElevated risk GG correlated with reduced lysoPLs, lysoPA, and ATX (autotaxin). Five other risk SNPs did not show this phenotype. LysoPL-lysoPA interconversion was uncoupled from ATX in GG plasma, suggesting metabolic dysregulation. Significantly altered expression of several lysoPL/lysoPA metabolizing enzymes was found in HEK cells lacking ANRIL. In the vascular smooth muscle cells data set, the presence of risk alleles associated with altered expression of several lysoPL/lysoPA enzymes. Deletion of the risk locus reversed the expression of several lysoPL/lysoPA genes to nonrisk haplotype levels. Genes that were altered across both cell data sets were DGKA, MBOAT2, PLPP1, and LPL. The in-silico analysis identified 4 ANRIL-regulated miRNAs that control lysoPL genes as miR-186-3p, miR-34a-3p, miR-122-5p, and miR-34a-5p.ConclusionsA Chr9p21 risk SNP associates with complex alterations in immune-bioactive phospholipids and their metabolism. Lipid metabolites and genomic pathways associated with coronary heart disease pathogenesis in Chr9p21 and ANRIL-associated disease are demonstrated.

Published
2020

20. Usefulness of lysophosphatidylcholine measurement in the cerebrospinal fluid for differential diagnosis of neuropathic pain: Possible introduction into clinical laboratory testing

Author

Kurano, Makoto, Sumitani, Masahiko, Akiyama, Yoshiyuki, Yamada, Masaki, Fujimura, Daiki, Yamaki, Satoshi, Kano, Kuniyuki, Aoki, Junken, Hayakawa, Kentaro, Takahashi, Takuya, Hirai, Takashi, Okawa, Atsushi, Kume, Haruki, Ogata, Toru, Tanaka, Sakae, Chikuda, Hirotaka, and Yatomi, Yutaka

Published
2023
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22. Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.

Author

Raimondi, Francesco, Inoue, Asuka, Kadji, Francois, Shuai, Ni, Gonzalez, Juan-Carlos, Singh, Gurdeep, de la Vega, Alicia, Sotillo, Rocio, Fischer, Bernd, Aoki, Junken, Gutkind, J, and Russell, Robert

Subjects
Chromogranins, Computational Biology, Epistasis, Genetic, GTP-Binding Protein alpha Subunits, Gs, Gene Frequency, Gene Regulatory Networks, Genes, Tumor Suppressor, HEK293 Cells, Humans, Models, Molecular, Multigene Family, Mutation, Neoplasms, Oncogenes, Receptors, G-Protein-Coupled, Signal Transduction, Survival Analysis, Transcription Factors
Abstract

Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or repression of key cancer-relevant pathways. However, as many pathways contain multiple members of the same gene family, individual mutations might be overlooked, as each family member would necessarily have a lower mutation frequency and thus not identified as significant in any one-gene-at-a-time analysis. Here, we looked for mutated, functional sequence positions in gene families that were mutually exclusive (in patients) with another gene in the same pathway, which identified both known and new candidate oncodrivers. For instance, many inactivating mutations in multiple G-protein (particularly Gi/o) coupled receptors, are mutually exclusive with Gαs oncogenic activating mutations, both of which ultimately enhance cAMP signalling. By integrating transcriptomics and interaction data, we show that the Gs pathway is upregulated in multiple cancer types, even those lacking known GNAS activating mutations. This suggests that cancer cells may develop alternative strategies to activate adenylate cyclase signalling in multiple cancer types. Our study provides a mechanistic interpretation for several rare somatic mutations in multi-gene oncodrivers, and offers possible explanations for known and potential off-label cancer treatments, suggesting new therapeutic opportunities.

Published
2019

23. Illuminating G-Protein-Coupling Selectivity of GPCRs

Author

Inoue, Asuka, Raimondi, Francesco, Kadji, Francois Marie Ngako, Singh, Gurdeep, Kishi, Takayuki, Uwamizu, Akiharu, Ono, Yuki, Shinjo, Yuji, Ishida, Satoru, Arang, Nadia, Kawakami, Kouki, Gutkind, J Silvio, Aoki, Junken, and Russell, Robert B

Subjects
Biochemistry and Cell Biology, Biological Sciences, Generic health relevance, Female, HEK293 Cells, Heterotrimeric GTP-Binding Proteins, Humans, Male, Models, Biological, PC-3 Cells, Receptors, G-Protein-Coupled, Signal Transduction, DREADD, G-protein-coupled receptors, HEK293 cells, NanoBiT, TGF-α shedding assay, bioinformatics, chimeric G protein, prediction, protein design, signaling, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Heterotrimetic G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. G-protein-coupling profiles govern GPCR-induced cellular responses, yet receptor sequence selectivity determinants remain elusive. Here, we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique Gα subunit C termini. For each receptor, we probed chimeric Gα subunit activation via a transforming growth factor-α (TGF-α) shedding response in HEK293 cells lacking endogenous Gq/11 and G12/13 proteins, and complemented G-protein-coupling profiles through a NanoBiT-G-protein dissociation assay. Interrogation of the dataset identified sequence-based coupling specificity features, inside and outside the transmembrane domain, which we used to develop a coupling predictor that outperforms previous methods. We used the predictor to engineer designer GPCRs selectively coupled to G12. This dataset of fine-tuned signaling mechanisms for diverse GPCRs is a valuable resource for research in GPCR signaling.

Published
2019

24. Introducing the Lipidomics Minimal Reporting Checklist

Author

McDonald, Jeffrey G., Ejsing, Christer S., Kopczynski, Dominik, Holčapek, Michal, Aoki, Junken, Arita, Makoto, Arita, Masanori, Baker, Erin S., Bertrand-Michel, Justine, Bowden, John A., Brügger, Britta, Ellis, Shane R., Fedorova, Maria, Griffiths, William J., Han, Xianlin, Hartler, Jürgen, Hoffmann, Nils, Koelmel, Jeremy P., Köfeler, Harald C., Mitchell, Todd W., O’Donnell, Valerie B., Saigusa, Daisuke, Schwudke, Dominik, Shevchenko, Andrej, Ulmer, Candice Z., Wenk, Markus R., Witting, Michael, Wolrab, Denise, Xia, Yu, Ahrends, Robert, Liebisch, Gerhard, and Ekroos, Kim

Published
2022
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26. TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis

Author

Petkevicius, Kasparas, Palmgren, Henrik, Glover, Matthew S., Ahnmark, Andrea, Andréasson, Anne-Christine, Madeyski-Bengtson, Katja, Kawana, Hiroki, Allman, Erik L., Kaper, Delaney, Uhrbom, Martin, Andersson, Liselotte, Aasehaug, Leif, Forsström, Johan, Wallin, Simonetta, Ahlstedt, Ingela, Leke, Renata, Karlsson, Daniel, González-King, Hernán, Löfgren, Lars, Nilsson, Ralf, Pellegrini, Giovanni, Kono, Nozomu, Aoki, Junken, Hess, Sonja, Sienski, Grzegorz, Pilon, Marc, Bohlooly-Y, Mohammad, Maresca, Marcello, and Peng, Xiao-Rong

Published
2022
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30. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism

Author

Yoshida, Yohko, Shimizu, Ippei, Shimada, Atsuhiro, Nakahara, Keita, Yanagisawa, Sachiko, Kubo, Minoru, Fukuda, Shinji, Ishii, Chiharu, Yamamoto, Hiromitsu, Ishikawa, Takamasa, Kano, Kuniyuki, Aoki, Junken, Katsuumi, Goro, Suda, Masayoshi, Ozaki, Kazuyuki, Yoshida, Yutaka, Okuda, Shujiro, Ohta, Shigeo, Okamoto, Shiki, Minokoshi, Yasuhiko, Oda, Kanako, Sasaoka, Toshikuni, Abe, Manabu, Sakimura, Kenji, Kubota, Yoshiaki, Yoshimura, Norihiko, Kajimura, Shingo, Zuriaga, Maria, Walsh, Kenneth, Soga, Tomoyoshi, and Minamino, Tohru

Published
2022
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35. Intracellular TAS2Rs act as a gatekeeper for the excretion of harmful substances via ABCB1 in keratinocytes.

Author

Mori, Sazanami, Nakamura, Natsuki, Fuchigami, Ayane, Yoshimoto, Satoshi, Sakakibara, Moe, Ozawa, Toshiyuki, Aoki, Junken, Inoue, Asuka, Sumida, Hayakazu, Ando, Hideya, and Nakamura, Motonao

Subjects
ATP-binding cassette transporters, BITTERNESS (Taste), P-glycoprotein, KERATINOCYTES, EXCRETION, TASTE receptors
Abstract

Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non‐taste perception and tissue‐specific functions. Keratinocytes that express TAS2Rs in the skin provide a first‐line defense against external threats. However, the functional roles of these receptors in host defense remain unclear. Here, we demonstrated the sensory role of intracellularly located TAS2Rs against toxic substances in keratinocytes. Although many G protein‐coupled receptors elicit signals from the surface, TAS2Rs were found to localize intracellularly, possibly to the ER, in human keratinocytes and HaCaT cells. TAS2R38, one of the TAS2R members, activated the Gα12/13/RhoA/ROCK/p38 MAP kinase/NF‐κB pathway upon stimulation by phenylthiocarbamide (PTC), an agonist for this receptor, leading to the production of ABC transporters, such as ABCB1, in these cells. Notably, treatment with bitter compounds, such as PTC and saccharin, induced the upregulation of ABCB1 in HaCaT cells. Mechanistically, intracellular TAS2R38 and its downstream signaling Gα12/13/RhoA/ROCK/p38 MAP kinase/NF‐κB pathway were identified to be responsible for the above effect. Pretreatment with PTC prevented the accumulation of rhodamine 123 because of its excretion via ABCB1. Furthermore, pretreatment with PTC or saccharin counteracted the effect of the toxic compound, diphenhydramine, and pretreated HaCaT cells were found to proliferate faster than untreated cells. This anti‐toxic effect was suppressed by treatment with verapamil, an ABCB1 inhibitor, indicating that enhanced ABCB1 helps clear toxic substances. Altogether, harmless activators of TAS2Rs may be promising drugs that enhance the excretion of toxic substances from the human skin. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques

Author

Nagatake, Takahiro, Kishino, Shigenobu, Urano, Emiko, Murakami, Haruka, Kitamura, Nahoko, Konishi, Kana, Ohno, Harumi, Tiwari, Prabha, Morimoto, Sakiko, Node, Eri, Adachi, Jun, Abe, Yuichi, Isoyama, Junko, Sawane, Kento, Honda, Tetsuya, Inoue, Asuka, Uwamizu, Akiharu, Matsuzaka, Takashi, Miyamoto, Yoichi, Hirata, So-ichiro, Saika, Azusa, Shibata, Yuki, Hosomi, Koji, Matsunaga, Ayu, Shimano, Hitoshi, Arita, Makoto, Aoki, Junken, Oka, Masahiro, Matsutani, Akira, Tomonaga, Takeshi, Kabashima, Kenji, Miyachi, Motohiko, Yasutomi, Yasuhiro, Ogawa, Jun, and Kunisawa, Jun

Published
2022
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37. Low MBOAT7 expression, a genetic risk for MASH, promotes a pro-fibrotic pathway involving hepatocyte TAZ upregulation

Author

Moore, Mary P., primary, Wang, Xiaobo, additional, Kennelly, John Paul, additional, Shi, Hongxue, additional, Ishino, Yuki, additional, Kano, Kuniyuki, additional, Aoki, Junken, additional, Cherubini, Alessandro, additional, Ronzoni, Luisa, additional, Guo, Xiuqing, additional, Chalasani, Naga P., additional, Khalid, Shareef, additional, Saleheen, Danish, additional, Mitsche, Mathew A., additional, Rotter, Jerome I., additional, Yates, Katherine P., additional, Valenti, Luca, additional, Kono, Nozomu, additional, Tontonoz, Peter, additional, and Tabas, Ira, additional

Published
2024
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38. Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils

Author

Etani, Hayato, primary, Takatori, Sho, additional, Wang, Wenbo, additional, Omi, Jumpei, additional, Akahori, Aika, additional, Watanabe, Hirotaka, additional, Sonn, Iki, additional, Okano, Hideyuki, additional, Hara, Norikazu, additional, Hasegawa, Mai, additional, Miyashita, Akinori, additional, Kikuchi, Masataka, additional, Ikeuchi, Takeshi, additional, Morishima, Maho, additional, Saito, Yuko, additional, Murayama, Shigeo, additional, Saito, Takashi, additional, Saido, Takaomi C, additional, Takai, Toshiyuki, additional, Ohwada, Tomohiko, additional, Aoki, Junken, additional, and Tomita, Taisuke, additional

Published
2024
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42. Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

Author

O'Hayre, Morgan, Eichel, Kelsie, Avino, Silvia, Zhao, Xuefeng, Steffen, Dana J, Feng, Xiaodong, Kawakami, Kouki, Aoki, Junken, Messer, Karen, Sunahara, Roger, Inoue, Asuka, von Zastrow, Mark, and Gutkind, J Silvio

Subjects
Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, Underpinning research, Animals, Endocytosis, Extracellular Signal-Regulated MAP Kinases, GTP Phosphohydrolases, HEK293 Cells, Humans, Ligands, Mice, Mice, Knockout, Phosphorylation, Protein Binding, RNA Interference, RNA, Small Interfering, Receptors, Adrenergic, beta-2, Signal Transduction, Transcription Activator-Like Effector Nucleases, beta-Arrestin 1, beta-Arrestin 2, Biochemistry and cell biology
Abstract

The β2-adrenergic receptor (β2AR) has provided a paradigm to elucidate how G protein-coupled receptors (GPCRs) control intracellular signaling, including the discovery that β-arrestins, which bind to ligand-activated GPCRs, are central for GPCR function. We used genome editing, conditional gene deletion, and small interfering RNAs (siRNAs) to determine the roles of β-arrestin 1 (β-arr1) and β-arr2 in β2AR internalization, trafficking, and signaling to ERK. We found that only β-arr2 was essential for β2AR internalization. Unexpectedly, β-arr1 and β-arr2 and receptor internalization were dispensable for ERK activation. Instead, β2AR signaled through Gαs and Gβγ subunits through a pathway that involved the tyrosine kinase SRC, the adaptor protein SHC, the guanine nucleotide exchange factor SOS, the small GTPase RAS, and the kinases RAF and MEK, which led to ERK activation. These findings provide a molecular framework for β2AR signaling through β-arrestin-independent pathways in key physiological functions and under pathological conditions.

Published
2017

47. Group III secreted phospholipase A2‐driven lysophospholipid pathway protects against allergic asthma

Author

Hamu‐Tanoue, Asako, primary, Takagi, Koichi, additional, Taketomi, Yoshitaka, additional, Miki, Yoshimi, additional, Nishito, Yasumasa, additional, Kano, Kuniyuki, additional, Aoki, Junken, additional, Matsuyama, Takahiro, additional, Kondo, Kiyotaka, additional, Dotake, Yoichi, additional, Matsuyama, Hiromi, additional, Machida, Kentaro, additional, Murakami, Makoto, additional, and Inoue, Hiromasa, additional

Published
2024
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48. New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line

Author

Sato, Kota, primary, Sasaki, Yuto, additional, Ohno-Oishi, Michiko, additional, Kano, Kuniyuki, additional, Aoki, Junken, additional, Ohsawa, Kosuke, additional, Doi, Takayuki, additional, Yamakoshi, Hiroyuki, additional, Iwabuchi, Yoshiharu, additional, Kawano, Chihiro, additional, Hirata, Yoshiyuki, additional, and Nakazawa, Toru, additional

Published
2024
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49. Polycyclic aromatic hydrocarbons in samples of Ryugu formed in the interstellar medium

Author

Zeichner, Sarah S., primary, Aponte, José C., additional, Bhattacharjee, Surjyendu, additional, Dong, Guannan, additional, Hofmann, Amy E., additional, Dworkin, Jason P., additional, Glavin, Daniel P., additional, Elsila, Jamie E., additional, Graham, Heather V., additional, Naraoka, Hiroshi, additional, Takano, Yoshinori, additional, Tachibana, Shogo, additional, Karp, Allison T., additional, Grice, Kliti, additional, Holman, Alex I., additional, Freeman, Katherine H., additional, Yurimoto, Hisayoshi, additional, Nakamura, Tomoki, additional, Noguchi, Takaaki, additional, Okazaki, Ryuji, additional, Yabuta, Hikaru, additional, Sakamoto, Kanako, additional, Yada, Toru, additional, Nishimura, Masahiro, additional, Nakato, Aiko, additional, Miyazaki, Akiko, additional, Yogata, Kasumi, additional, Abe, Masanao, additional, Okada, Tatsuaki, additional, Usui, Tomohiro, additional, Yoshikawa, Makoto, additional, Saiki, Takanao, additional, Tanaka, Satoshi, additional, Terui, Fuyuto, additional, Nakazawa, Satoru, additional, Watanabe, Sei-ichiro, additional, Tsuda, Yuichi, additional, Hamase, Kenji, additional, Fukushima, Kazuhiko, additional, Aoki, Dan, additional, Hashiguchi, Minako, additional, Mita, Hajime, additional, Chikaraishi, Yoshito, additional, Ohkouchi, Naohiko, additional, Ogawa, Nanako O., additional, Sakai, Saburo, additional, Parker, Eric T., additional, McLain, Hannah L., additional, Orthous-Daunay, Francois-Regis, additional, Vuitton, Véronique, additional, Wolters, Cédric, additional, Schmitt-Kopplin, Philippe, additional, Hertkorn, Norbert, additional, Thissen, Roland, additional, Ruf, Alexander, additional, Isa, Junko, additional, Oba, Yasuhiro, additional, Koga, Toshiki, additional, Yoshimura, Toshihiro, additional, Araoka, Daisuke, additional, Sugahara, Haruna, additional, Furusho, Aogu, additional, Furukawa, Yoshihiro, additional, Aoki, Junken, additional, Kano, Kuniyuki, additional, Nomura, Shin-ichiro M., additional, Sasaki, Kazunori, additional, Sato, Hajime, additional, Yoshikawa, Takaaki, additional, Tanaka, Satoru, additional, Morita, Mayu, additional, Onose, Morihiko, additional, Kabashima, Fumie, additional, Fujishima, Kosuke, additional, Yamazaki, Tomoya, additional, Kimura, Yuki, additional, and Eiler, John M., additional

Published
2023
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