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339 results on '"Ao, Hui"'

23. Research progress of tumorigenicity-related proteins

Author

AO Hui-juan, SHI Jia-chen, WANG Jia-min, Ayimuguli ABUDUREYIMU, QIAO Zi-lin, YANG Kun

Subjects
tumor cells, tumorigenicity, protein, Medicine
Abstract

The occurrence and development of tumors include the tumorigenicity of tumor cells in vivo, the growth of xenograft tumors, angiogenesis, tumor migration, invasion and metastasis. Tumorigenicity-related proteins play an important regulatory role during these processes. Research of tumorigenicity-related proteins is of great significance for identifing new targets for tumor treatment and blocking tumor occurrence and development. We reviewed the effects of tumorigenicity-related proteins on cell tumorigenesis, the consequence of protein interactions on tumor migration and invasion, the effects of tumorigenicity-related proteins on cell migration and invasion in vitro, and their relationship with tumor metastasis. This review provides rich information on the regulatory mechanism of tumorigenicity-related proteins in tumor development.

Published
2020

28. Mechanism of Pydiflumetofen Resistance in Fusarium graminearum in China

Author

Feng Zhou, Huan-Huan Zhou, Ao-Hui Han, Kou-Yun Guo, Tian-Cheng Liu, Yan-Bing Wu, Hai-Yan Hu, and Cheng-Wei Li

Subjects
Fusarium graminearum, pydiflumetofen, fungicide resistance, molecular mechanism, cross-resistance, Biology (General), QH301-705.5
Abstract

Fusarium head blight (FHB), which is primarily caused by Fusarium graminearum, is a widespread and devastating disease of wheat. In the absence of resistant varieties, the control of FHB relies heavily on the application of fungicides, and the new generation SDHI fungicide, pydiflumetofen, has recently been registered in China for the control of FHB in wheat. The current study explored three genetically stable, highly resistant laboratory mutants (S2-4-2R, S27-3R, and S28-2R, with EC50 values of 25.10, 28.57, and 19.22 μg/mL, respectively) to investigate the potential risks associated with pydiflumetofen resistance. Although the mycelial growth of the mutants differed little compared to their parental isolates, the study found that the resistant mutants exhibited significantly reduced (p < 0.05) levels of sporulation and pathogenicity, which suggests a significant fitness cost associated with pydiflumetofen resistance in F. graminearum. Sequence analysis of the Sdh target protein identified numerous amino acid substitutions in the predicted sequences of the four subunits: FgSdhA, FgSdhB, FgSdhC, and FgSdhD. Indeed, the mutants were found to have a series of substitution in multiple subunits such that all three exhibited five identical changes, including Y182F in the FgSdhA subunit; H53Q, C90S, and A94V in FgSdhB; and S31F in FgSdhC. In addition, gene expression analysis revealed that all of the FgSdh genes had significantly altered expression (p < 0.05), particularly FgSdhA and FgdhC, which exhibited remarkably low levels of expression. However, the study found no evidence of cross-resistance between pydiflumetofen and tebuconazole, fludioxonil, prochloraz, fluazinam, carbendazim, pyraclostrobin, or difenoconazole, which indicates that these fungicides, either in rotation or combination with pydiflumetofen, could mitigate the risk of resistance emerging and provide ongoing control of FHB to ensure high and stable wheat yields.

Published
2022
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30. Therapeutic potential of dietary flavonoid hyperoside against non-communicable diseases: targeting underlying properties of diseases.

Author

Xia, Jia, Wan, Yan, Wu, Jiao-jiao, Yang, Yu, Xu, Jin-Feng, Zhang, Li, Liu, Dong, Chen, Lu, Tang, Fei, Ao, Hui, and Peng, Cheng

Subjects
NUCLEAR factor E2 related factor, NON-communicable diseases, FLAVONOIDS, ANTIOXIDANTS
Abstract

Non-communicable diseases (NCDs) are a global epidemic with diverse pathogenesis. Among them, oxidative stress and inflammation are the most fundamental co-morbid features. Therefore, multi-targets and multi-pathways therapies with significant anti-oxidant and anti-inflammatory activities are potential effective measures for preventing and treating NCDs. The flavonol glycoside compound hyperoside (Hyp) is widely found in a variety of fruits, vegetables, beverages, and medicinal plants and has various health benefits, especially excellent anti-oxidant and anti-inflammatory properties targeting nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-κB (NF-κB) signaling pathways. In this review, we summarize the pathogenesis associated with oxidative stress and inflammation in NCDs and the biological activity and therapeutic potential of Hyp. Our findings reveal that the anti-oxidant and anti-inflammatory activities regulated by Hyp are associated with numerous biological mechanisms, including positive regulation of mitochondrial function, apoptosis, autophagy, and higher-level biological damage activities. Hyp is thought to be beneficial against organ injuries, cancer, depression, diabetes, and osteoporosis, and is a potent anti-NCDs agent. Additionally, the sources, bioavailability, pharmacy, and safety of Hyp have been established, highlighting the potential to develop Hyp into dietary supplements and nutraceuticals. [ABSTRACT FROM AUTHOR]

Published
2024
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