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3. NMR-based metabolomic approach to study urine samples of chronic inflammatory rheumatic disease patients

Author

Vignoli, Alessia, Rodio, Donatella Maria, Bellizzi, Anna, Sobolev, Anatoly Petrovich, Anzivino, Elena, Mischitelli, Monica, Tenori, Leonardo, Marini, Federico, Priori, Roberta, Scrivo, Rossana, Valesini, Guido, Francia, Ada, Morreale, Manuela, Ciardi, Maria Rosa, Iannetta, Marco, Campanella, Cristiana, Capitani, Donatella, Luchinat, Claudio, Pietropaolo, Valeria, and Mannina, Luisa

Published
2017
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11. Early monitoring of the human polyomavirus BK replication and sequencing analysis in a cohort of adult kidney transplant patients treated with basiliximab

Author

Mischitelli Monica, Fioriti Daniela, Colosimo Maria, Barile Mario, Tinti Francesca, Mitterhofer Anna, Bellizzi Anna, Anzivino Elena, Chiarini Fernanda, Ferretti Giancarlo, Taliani Gloria, and Pietropaolo Valeria

Subjects
BKV, BKVAN, basiliximab, Q-PCR, TCR, VP1, BKV subtype/subgroup, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Nowadays, better immunosuppressors have decreased the rates of acute rejection in kidney transplantation, but have also led to the emergence of BKV-associated nephropathy (BKVAN). Therefore, we prospectively investigated BKV load in plasma and urine samples in a cohort of kidney transplants, receiving basiliximab combined with a mycophenolate mofetil-based triple immunotherapy, to evaluate the difference between BKV replication during the first 3 months post-transplantation, characterized by the non-depleting action of basiliximab, versus the second 3 months, in which the maintenance therapy acts alone. We also performed sequencing analysis to assess whether a particular BKV subtype/subgroup or transcriptional control region (TCR) variants were present. Methods We monitored BK viruria and viremia by quantitative polymerase chain reaction (Q-PCR) at 12 hours (Tx), 1 (T1), 3 (T2) and 6 (T3) months post-transplantation among 60 kidney transplant patients. Sequencing analysis was performed by nested-PCR with specific primers for TCR and VP1 regions. Data were statistically analyzed using χ2 test and Student's t-test. Results BKV was detected at Tx in 4/60 urine and in 16/60 plasma, with median viral loads of 3,70 log GEq/mL and 3,79 log GEq/mL, respectively, followed by a significant increase of both BKV-positive transplants (32/60) and median values of viruria (5,78 log GEq/mL) and viremia (4,52 log GEq/mL) at T2. Conversely, a significantly decrease of patients with viruria and viremia (17/60) was observed at T3, together with a reduction of the median urinary and plasma viral loads (4,09 log GEq/mL and 4,00 log GEq/mL, respectively). BKV TCR sequence analysis always showed the presence of archetypal sequences, with a few single-nucleotide substitutions and one nucleotide insertion that, interestingly, were all representative of the particular subtypes/subgroups we identified by VP1 sequencing analysis: I/b-2 and IV/c-2. Conclusions Our results confirm previous studies indicating that BKV replication may occur during the early hours after kidney transplantation, reaches the highest incidence in the third post-transplantation month and then decreases within the sixth month, maybe due to induction therapy. Moreover, it might become clinically useful whether specific BKV subtypes or rearrangements could be linked to a particular disease state in order to detect them before BKVAN onset.

Published
2011
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12. Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and prevention

Author

Barucca Valentina, Bellizzi Anna, Mischitelli Monica, Fioriti Daniela, Anzivino Elena, Chiarini Fernanda, and Pietropaolo Valeria

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Herpes simplex virus (HSV) infection is one of the most common viral sexually transmitted diseases worldwide. The first time infection of the mother may lead to severe illness in pregnancy and may be associated with virus transmission from mother to foetus/newborn. Since the incidence of this sexually transmitted infection continues to rise and because the greatest incidence of herpes simplex virus infections occur in women of reproductive age, the risk of maternal transmission of the virus to the foetus or neonate has become a major health concern. On these purposes the Authors of this review looked for the medical literature and pertinent publications to define the status of art regarding the epidemiology, the diagnosis, the therapy and the prevention of HSV in pregnant women and neonate. Special emphasis is placed upon the importance of genital herpes simplex virus infection in pregnancy and on the its prevention to avoid neonatal HSV infections.

Published
2009
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13. Complications post renal transplantation: literature focus on BK virus nephropathy and diagnostic tools actually available

Author

Miglio Umberto, Boldorini Renzo, Fioriti Daniela, Anzivino Elena, Bellizzi Anna, Mischitelli Monica, Chiarini Fernanda, Di Monaco Franco, and Pietropaolo Valeria

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Clinical diagnosis of kidney transplants related illnesses is not a simple task. Several studies were conducted to define diseases and complications after renal transplantation, but there are no comprehensive guidelines about diagnostic tools for their prevention and detection. The Authors of this review looked for the medical literature and pertinent publications in particular to understand the role of Human Polyomavirus BK (BKV) in renal failure and to recognize analytical techniques for BK virus associated nephropathy (BKVAN) detection.

Published
2008
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14. JC Virus-DNA Detection Is Associated with CD8 Effector Accumulation in Peripheral Blood of Patients with Multiple Sclerosis under Natalizumab Treatment, Independently from JC Virus Serostatus

Author

Zingaropoli, Maria A., primary, Iannetta, Marco, additional, Pontecorvo, Simona, additional, Anzivino, Elena, additional, Prezioso, Carla, additional, Rodio, Donatella Maria, additional, Morreale, Manuela, additional, D’Abramo, Alessandra, additional, Oliva, Alessandra, additional, Lichtner, Miriam, additional, Cortese, Antonio, additional, Frontoni, Marco, additional, Pietropaolo, Valeria, additional, Francia, Ada, additional, Mastroianni, Claudio M., additional, Vullo, Vincenzo, additional, and Ciardi, Maria R., additional

Published
2018
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16. Polyomavirus BK Infection Before Liver Transplantation in Patients With Chronic Kidney Disease

Author

Mitterhofer, Anna Paola, Tinti, Francesca, Umbro, Ilaria, Pietropaolo, Valeria Antonietta, Fiacco, F., Bellizzi, Anna, Anzivino, Elena, GINANNI CORRADINI, Stefano, Stefano Ginanni Corradini, Poli, Luca, Rossi, Massimo, Berloco, Pasquale Bartolomeo, Ferretti, G., Chiarini, Fernanda, and Taliani, Gloria

Subjects
Adult, Male, medicine.medical_specialty, viruses, medicine.medical_treatment, Viremia, Liver transplantation, Biology, Real-Time Polymerase Chain Reaction, Virus Replication, urologic and male genital diseases, Gastroenterology, Nephropathy, Liver disease, symbols.namesake, Internal medicine, medicine, Humans, Risk factor, Fisher's exact test, Polyomavirus Infections, Transplantation, virus diseases, Middle Aged, medicine.disease, Virology, female genital diseases and pregnancy complications, Liver Transplantation, liver transplantation, renal transplantation, chronic kidney disease, polyomavirus bk, BK Virus, symbols, Kidney Failure, Chronic, Female, Surgery, Kidney disease
Abstract

End-stage liver disease (ESLD) and chronic kidney disease (CKD) patients are both immunocompromised populations but polyomavirus BK (BKV) replication before liver transplantation is rare. We evaluated BKV prevalence among liver transplant recipients with renal dysfunction and the possible role of CKD as a risk factor for BKV replication in ESLD. From 2010 to 2011 we selected 31 ESLD patients awaiting liver transplantation to identify, the presence of CKD: No CKD (n = 22; 18 males) and CKD group (n = 9; 5 males). BKV infection was defined on the basis of viremia evaluated using quantitative real-time polymerase chain reactions. The prevalence of viremia among the No CKD group was 14% versus 56% in the CKD group (Fisher test; P = .027). We hypothesized that the presence of CKD may represent an additional condition of immunologic dysfunction regarding antiviral surveillances other than the antibacterial one that characterizes ESLD immunodysfunction, which could have promoted BKV replication. The specific immunologic mechanisms involved in pretransplantation diseases may have a role in BKV reactivation that could become responsible for nephropathy after transplantation.

Published
2012
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23. NMR-based metabolomic approach to study urine samples of chronic inflammatory rheumatic disease patients

Author

Vignoli, Alessia, primary, Rodio, Donatella Maria, additional, Bellizzi, Anna, additional, Sobolev, Anatoly Petrovich, additional, Anzivino, Elena, additional, Mischitelli, Monica, additional, Tenori, Leonardo, additional, Marini, Federico, additional, Priori, Roberta, additional, Scrivo, Rossana, additional, Valesini, Guido, additional, Francia, Ada, additional, Morreale, Manuela, additional, Ciardi, Maria Rosa, additional, Iannetta, Marco, additional, Campanella, Cristiana, additional, Capitani, Donatella, additional, Luchinat, Claudio, additional, Pietropaolo, Valeria, additional, and Mannina, Luisa, additional

Published
2016
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24. Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals

Author

ANZIVINO, ELENA, primary, ZINGAROPOLI, MARIA ANTONELLA, additional, IANNETTA, MARCO, additional, PIETROPAOLO, VALERIA ANTONIETTA, additional, OLIVA, ALESSANDRA, additional, IORI, FRANCESCO, additional, CIARDI, ANTONIO, additional, RODIO, DONATELLA MARIA, additional, ANTONINI, FRANCESCA, additional, FEDELE, CESARE GIOVANNI, additional, D’ABRAMO, ALESSANDRA, additional, MASTROIANNI, CLAUDIO MARIA, additional, VULLO, VINCENZO, additional, and CIARDI, MARIA ROSA, additional

Published
2016
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25. Natalizumab Affects T-Cell Phenotype in Multiple Sclerosis: Implications for JCV Reactivation

Author

Iannetta, Marco, primary, Zingaropoli, Maria Antonella, additional, Bellizzi, Anna, additional, Morreale, Manuela, additional, Pontecorvo, Simona, additional, D’Abramo, Alessandra, additional, Oliva, Alessandra, additional, Anzivino, Elena, additional, Lo Menzo, Sara, additional, D’Agostino, Claudia, additional, Mastroianni, Claudio Maria, additional, Millefiorini, Enrico, additional, Pietropaolo, Valeria, additional, Francia, Ada, additional, Vullo, Vincenzo, additional, and Ciardi, Maria Rosa, additional

Published
2016
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26. Increased Prevalence of Human Polyomavirus JC Viruria in Chronic Inflammatory Rheumatic Diseases Patients in Treatment with Anti-TNF α: A 18 Month Follow-Up Study

Author

Rodio, Donatella Maria, primary, Anzivino, Elena, additional, Mischitelli, Monica, additional, Bellizzi, Anna, additional, Scrivo, Rossana, additional, Scribano, Daniela, additional, Conte, Gianlorenzo, additional, Prezioso, Carla, additional, Trancassini, Maria, additional, Valesini, Guido, additional, Palamara, Anna Teresa, additional, and Pietropaolo, Valeria, additional

Published
2016
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27. New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy

Author

Bellizzi, Anna, Anzivino, Elena, Rodio, Donatella Maria, Palamara, Anna Teresa, Nencioni, Lucia, and Pietropaolo, Valeria

Subjects
Article Subject, viruses, virus diseases
Abstract

John Cunningham virus (JCV) is a member of the Polyomaviridae family. It was first isolated from the brain of a patient with Hodgkin disease in 1971, and since then the etiological agent of the progressive multifocal leukoencephalopathy (PML) was considered. Until the human immunodeficiency virus (HIV) pandemic, PML was rare: in fact HIV-induced immunodeficiency is the most common predisposing factor accounting for 85% of all instances of PML. This data led to intense research on JCV infection and resulted in better understanding of epidemiology and clinic-pathologic spectrum. Recently, cases of PML have been observed after the introduction of monoclonal antibodies, such as natalizumab, rituximab, efalizumab, and infliximab, in the treatment of autoimmune disease, underlining the important role of host immunity in PML pathogenesis. In this review current understanding of the JCV infection and the new findings relating to the pathogenesis of PML has been comprehensively revised, focusing our attention on the interaction between the cellular and viral molecular pathways implicated in the JCV infection and the modulating role of host immune surveillance in the viral reactivation from a latent state.

Published
2013
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29. Biological agents therapy in crohn's disease

Author

Bellizzi, Anna, Anzivino, Elena, Rodio, DONATELLA MARIA, Fioriti, Daniela, Mischitelli, Monica, Chiarini, Fernanda, and Pietropaolo, Valeria Antonietta

Subjects
crohn’s disease, pml, crohn's disease, biological agents, human polyomavirus jc reactivation
Published
2013

34. Human Polyomavirus JC monitoring and noncoding control region analysis in dynamic cohorts of individuals affected by multiple sclerosis under treatment with natalizumab: an observational study

Author

Bellizzi, Anna, Anzivino, Elena, Rodio, DONATELLA MARIA, Cioccolo, S., Morreale, Manuela, Pontecorvo, Simona, Carluccio, S., Nencioni, Lucia, Francia, Ada, Palamara, ANNA TERESA, and Pietropaolo, Valeria Antonietta

Subjects
jcpyv-specific antibodies, jcpyv, nccr, vp1, multiple sclerosis, natalizumab, q-pcr
Published
2013

44. Human polyomavirus JC presence in chronic inflammatory rheumatic diseases patients treated with anti-TNF-α: Evaluation of JC viral loads in urine and plasma samples

Author

Bellizzi, Anna, primary, Mischitelli, Monica, additional, Anzivino, Elena, additional, Scrivo, Rossana, additional, Rodio, Donatella Maria, additional, Scribano, Daniela, additional, Cacciotti, Fatima, additional, Cioccolo, Sara, additional, Delbue, Serena, additional, Valesini, Guido, additional, and Pietropaolo, Valeria, additional

Published
2015
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45. THE ONCOGENIC POTENTIAL OF HUMAN POLYOMAVIRUSIIK IN PROSTATE CANCER

Author

Salciccia, Stefano, Alfarone, Andrea, Cattarino, Susanna, Mischitelli, Monica, Fioriti, Daniela, Bellizzi, Anna, Anzivino, Elena, Barucca, V., Colosimo, M. T., Sciarra, Alessandro, DI SILVERIO, Franco, Chiarini, Fernanda, and Pietropaolo, Valeria Antonietta

Published
2010

50. BKV QPCR detection and infection monitoring in renal transplant recipients

Author

Mischitelli, Monica, Fioriti, Daniela, Anzivino, Elena, Bellizzi, Anna, Ferretti, G, Gussman, N, Mitterhofer, Anna Paola, Tinti, Francesca, Barile, Mario, DAL MASO, M, Chiarini, Fernanda, and Pietropaolo, Valeria Antonietta

Subjects
Male, Polyomavirus Infections, Time Factors, Q-PCR, BKV associated nephropathy (BKVAN), Middle Aged, Viral Load, Kidney Transplantation, Polymerase Chain Reaction, Sensitivity and Specificity, Tumor Virus Infections, Postoperative Complications, BK Virus, DNA, Viral, Humans, Female, Kidney Diseases, Biomarkers
Abstract

BKV associated nephropathy (BKVAN) is a cause of renal dysfunction and loss of the graft in transplants. Viral primary infection is usually inapparent and then BKV establishes latency in kidneys. Reactivation occurs in immunocompromised conditions in renal transplant recipients who can develop a subclinical nephritis and eventually a BKV-associated interstitial nephritis or a BKVAN. In this study, we searched for BKV copies in urine and plasma of renal transplants by quantitative assay (QPCR). Results showed that in several patients clearance of viremia is associated with persistent viruria, suggesting that both specimens are necessary to correctly monitor a BKVAN.

Published
2007

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