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420 results on '"Anzalone, Nicoletta"'

1. Liquid biopsy of cerebrospinal fluid enabling the detection and therapeutic targeting of the BRAFV600E mutation in a patient with overlapping Erdheim-Chester/Rosai-Dorfman disease

Author

Pieri, Valentina, Berzero, Giulia, Paterra, Rosina, Ferré, Laura, Tomelleri, Alessandro, Campochiaro, Corrado, Esposito, Federica, Calimeri, Teresa, Cangi, Maria Giulia, Tenace, Nazario Pio, Ferreri, Andrés José María, Castellano, Antonella, Barbera, Maurizio, Anzalone, Nicoletta, Gay, Lorenzo Gabriel, Bello, Lorenzo, Colecchia, Maurizio, Ponzoni, Maurilio, Finocchiaro, Gaetano, and Filippi, Massimo

Published
2024
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6. Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the International Primary CNS Lymphoma Collaborative Group (IPCG)

Author

Barajas, Ramon F, Politi, Letterio S, Anzalone, Nicoletta, Schöder, Heiko, Fox, Christopher P, Boxerman, Jerrold L, Kaufmann, Timothy J, Quarles, C Chad, Ellingson, Benjamin M, Auer, Dorothee, Andronesi, Ovidiu C, Ferreri, Andres JM, Mrugala, Maciej M, Grommes, Christian, Neuwelt, Edward A, Ambady, Prakash, Rubenstein, James L, Illerhaus, Gerald, Nagane, Motoo, Batchelor, Tracy T, and Hu, Leland S

Subjects
Clinical Research, Cancer, Rare Diseases, Patient Safety, Biomedical Imaging, Lymphoma, Neurosciences, Hematology, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Central Nervous System, Central Nervous System Neoplasms, Consensus, Humans, Magnetic Resonance Imaging, Positron-Emission Tomography, Reproducibility of Results, imaging, MRI, PCNSL, PET, primary central nervous system lymphoma, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Advanced molecular and pathophysiologic characterization of primary central nervous system lymphoma (PCNSL) has revealed insights into promising targeted therapeutic approaches. Medical imaging plays a fundamental role in PCNSL diagnosis, staging, and response assessment. Institutional imaging variation and inconsistent clinical trial reporting diminishes the reliability and reproducibility of clinical response assessment. In this context, we aimed to: (1) critically review the use of advanced positron emission tomography (PET) and magnetic resonance imaging (MRI) in the setting of PCNSL; (2) provide results from an international survey of clinical sites describing the current practices for routine and advanced imaging, and (3) provide biologically based recommendations from the International PCNSL Collaborative Group (IPCG) on adaptation of standardized imaging practices. The IPCG provides PET and MRI consensus recommendations built upon previous recommendations for standardized brain tumor imaging protocols (BTIP) in primary and metastatic disease. A biologically integrated approach is provided to addresses the unique challenges associated with the imaging assessment of PCNSL. Detailed imaging parameters facilitate the adoption of these recommendations by researchers and clinicians. To enhance clinical feasibility, we have developed both "ideal" and "minimum standard" protocols at 3T and 1.5T MR systems that will facilitate widespread adoption.

Published
2021

13. Improving the antitumor activity of R-CHOP with NGR-hTNF in primary CNS lymphoma: final results of a phase 2 trial

Author

Ferreri, Andrés J.M., Calimeri, Teresa, Ponzoni, Maurilio, Curnis, Flavio, Conte, Gian Marco, Scarano, Eloise, Rrapaj, Eltjona, De Lorenzo, Daniela, Cattaneo, Dario, Fallanca, Federico, Nonis, Alessandro, Foppoli, Marco, Lopedote, Paolo, Citterio, Giovanni, Politi, Letterio S., Sassone, Marianna, Angelillo, Piera, Guggiari, Elena, Steffanoni, Sara, Tarantino, Vittoria, Ciceri, Fabio, Bordignon, Claudio, Anzalone, Nicoletta, and Corti, Angelo

Published
2020
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16. Progression of brain white matter hyperintensities in asymptomatic patients with carotid atherosclerotic plaques and no indication for revascularization

Author

Ammirati, Enrico, Moroni, Francesco, Magnoni, Marco, Rocca, Maria A., Anzalone, Nicoletta, Cacciaguerra, Laura, Di Terlizzi, Simona, Villa, Chiara, Sizzano, Federico, Palini, Alessio, Scotti, Isabella, Besana, Francesca, Spagnolo, Pietro, Rimoldi, Ornella E., Chiesa, Roberto, Falini, Andrea, Filippi, Massimo, and Camici, Paolo G.

Published
2019
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18. R-CHOP preceded by blood-brain barrier permeabilization with engineered tumor necrosis factor-α in primary CNS lymphoma

Author

Ferreri, Andrés J.M., Calimeri, Teresa, Conte, Gian Marco, Cattaneo, Dario, Fallanca, Federico, Ponzoni, Maurilio, Scarano, Eloise, Curnis, Flavio, Nonis, Alessandro, Lopedote, Paolo, Citterio, Giovanni, Politi, Letterio S., Foppoli, Marco, Girlanda, Stefania, Sassone, Marianna, Perrone, Salvatore, Cecchetti, Caterina, Ciceri, Fabio, Bordignon, Claudio, Corti, Angelo, and Anzalone, Nicoletta

Published
2019
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19. Molecular diagnosis of primary CNS lymphoma in 2024 using MYD88Leu265Proand IL-10

Author

Calimeri, Teresa, Anzalone, Nicoletta, Cangi, Maria Giulia, Fiore, Paolo, Gagliardi, Filippo, Miserocchi, Elisabetta, Ponzoni, Maurilio, and Ferreri, Andrés J M

Abstract

Early diagnosis is crucial for the successful treatment of primary CNS lymphoma (PCNSL), a rapidly progressing tumour. Suspicion raised on brain MRI must be confirmed by a histopathological diagnosis of a tumour specimen collected by stereotactic biopsy. In rare cases, cerebrospinal fluid (CSF) or vitreous humour might aid in providing a cytological diagnosis. Several disease-related, patient-related, and treatment-related factors affect the timing and accuracy of diagnosis and patient outcome. Some molecules detected in CSF, aqueous and vitreous humour, and peripheral blood were proposed as diagnostic biomarkers for PCNSL; however, detection methods for most of these molecules are not yet standardised, have a long turnaround time, are expensive, and have little reproducibility among labs. By contrast, the MYD88Leu265Prosomatic hotspot mutation, revealed by PCR-based assay, is currently and reliably used during the diagnosis of some lymphomas, and IL-10, measured by enzyme-linked immunosorbent assay, is routinely used to diagnose and monitor different common metabolic and immunological diseases. Several independent studies have shown that MYD88Leu265Proand IL-10 can be easily assessed in peripheral blood, plasma, aqueous and vitreous humour, and CSF of patients with PCNSL with substantial sensitivity and specificity, especially when evaluated in combination. In this Viewpoint, evidence supporting the routine use of MYD88Leu265Proand IL-10 in diagnosing PCNSL is considered, and some examples of the frequent difficulties found in the diagnosis of PCNSL are provided, highlighting the role and indications of these two biomarkers to improve the timely recognition of this aggressive tumour.

Published
2024
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20. The Contribution of Vessel Wall Magnetic Resonance Imaging to the Diagnosis of Primary and Secondary Central Nervous System Vasculitis.

Author

D'Aniello, Serena, Rustici, Arianna, Gramegna, Laura Ludovica, Godi, Claudia, Piccolo, Laura, Gentile, Mauro, Zini, Andrea, Carrozzi, Alessandro, Lodi, Raffaele, Tonon, Caterina, Dall'Olio, Massimo, Simonetti, Luigi, Chieffo, Raffaella, Anzalone, Nicoletta, and Cirillo, Luigi

Subjects
MAGNETIC resonance imaging, CENTRAL nervous system, VASCULITIS, LEUKOCYTOCLASTIC vasculitis, DIAGNOSIS
Abstract

Background: To describe high-resolution brain vessel wall MRI (VW-MRI) patterns and morphological brain findings in central nervous system (CNS) vasculitis patients. Methods: Fourteen patients with confirmed CNS Vasculitis from two tertiary centers underwent VW-MRI using a 3T scanner. The images were reviewed by two neuroradiologists to assess vessel wall enhancement characteristics and locations. Results: Fourteen patients were included (six females; average age 48 ± 19 years). Diagnoses included primary CNS vasculitis (PCNSV) in six patients and secondary CNS vasculitis (SCNSV) in eight, half of which were infection-related. Thirteen patients showed vessel wall enhancement, which was intense in eleven patients (84.6%) and concentric in twelve (92.3%), affecting the anterior circulation in nine patients (69.2%), posterior in two patients (15.4%), and both circulations in two patients (15.4%). The enhancement patterns were similar across different CNS vasculitis types. DWI changes corresponded with areas of vessel wall enhancement in 77% of patients. Conclusions: CNS vasculitis is often associated with intense, concentric vessel wall enhancement in VW-MRI, especially in the anterior circulation. The consistent presence of DWI alterations in affected territories suggests a possible link to microembolization or hypoperfusion. These imaging findings complement parenchymal brain MRI and MRA/DSA data, potentially increasing the possibility of a clinical diagnosis of CNS vasculitis. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Liquid biopsy of cerebrospinal fluid enabling the detection and therapeutic targeting of the BRAFV600E mutation in a patient with overlapping Erdheim-Chester/Rosai-Dorfman disease

Author

Pieri, Valentina, primary, Berzero, Giulia, additional, Paterra, Rosina, additional, Ferré, Laura, additional, Tomelleri, Alessandro, additional, Campochiaro, Corrado, additional, Esposito, Federica, additional, Calimeri, Teresa, additional, Cangi, Maria Giulia, additional, Tenace, Nazario Pio, additional, Ferreri, Andrés José María, additional, Castellano, Antonella, additional, Barbera, Maurizio, additional, Anzalone, Nicoletta, additional, Gay, Lorenzo Gabriel, additional, Bello, Lorenzo, additional, Colecchia, Maurizio, additional, Ponzoni, Maurilio, additional, Finocchiaro, Gaetano, additional, and Filippi, Massimo, additional

Published
2023
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30. Machine learning assisted DSC-MRI radiomics as a tool for glioma classification by grade and mutation status

Author

Sudre, Carole H., Panovska-Griffiths, Jasmina, Sanverdi, Eser, Brandner, Sebastian, Katsaros, Vasileios K., Stranjalis, George, Pizzini, Francesca B., Ghimenton, Claudio, Surlan-Popovic, Katarina, Avsenik, Jernej, Spampinato, Maria Vittoria, Nigro, Mario, Chatterjee, Arindam R., Attye, Arnaud, Grand, Sylvie, Krainik, Alexandre, Anzalone, Nicoletta, Conte, Gian Marco, Romeo, Valeria, Ugga, Lorenzo, Elefante, Andrea, Ciceri, Elisa Francesca, Guadagno, Elia, Kapsalaki, Eftychia, Roettger, Diana, Gonzalez, Javier, Boutelier, Timothé, Cardoso, M. Jorge, and Bisdas, Sotirios

Published
2020
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31. Liquid biopsy of cerebrospinal fluid enabling the detection and therapeutic targeting of the BRAFV600E mutation in a patient with overlapping Erdheim-Chester/Rosai-Dorfman disease.

Author

Pieri, Valentina, Berzero, Giulia, Paterra, Rosina, Ferré, Laura, Tomelleri, Alessandro, Campochiaro, Corrado, Esposito, Federica, Calimeri, Teresa, Cangi, Maria Giulia, Tenace, Nazario Pio, Ferreri, Andrés José María, Castellano, Antonella, Barbera, Maurizio, Anzalone, Nicoletta, Gay, Lorenzo Gabriel, Bello, Lorenzo, Colecchia, Maurizio, Ponzoni, Maurilio, Finocchiaro, Gaetano, and Filippi, Massimo

Subjects
ERDHEIM-Chester disease, CEREBROSPINAL fluid, DRUG target, GENETIC mutation
Abstract

This article discusses the use of liquid biopsy of cerebrospinal fluid (CSF) to detect and target the BRAFV600E mutation in a patient with overlapping Erdheim-Chester Disease (ECD) and Rosai-Dorfman Disease (RDD). ECD and RDD are rare histiocytic disorders driven by genetic alterations in the MAP kinase pathway. The patient in this case had CNS involvement, and the liquid biopsy of CSF and plasma was crucial in driving the diagnostic work-up and identifying the BRAFV600E mutation. This case highlights the potential value of liquid biopsies in diagnosing and targeting therapeutic interventions in patients with histiocytoses and CNS involvement. [Extracted from the article]

Published
2024
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33. Imaging characterization of an adult H3 K27M-altered diffuse midline glioma of the medulla oblongata with a confounding steroid response

Author

Godi, Claudia, primary, Garofalo, Paolo, additional, Callea, Marcella, additional, Vezzulli, Paolo, additional, Barbera, Maurizio, additional, Mandelli, Carlo, additional, Mazza, Elena, additional, Pollo, Bianca, additional, Terreni, Maria Rosa, additional, Castellano, Antonella, additional, Anzalone, Nicoletta, additional, and Falini, Andrea, additional

Published
2023
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35. Radiomics-Based Machine Learning Model for Predicting Overall and Progression-Free Survival in Rare Cancer: A Case Study for Primary CNS Lymphoma Patients

Author

Destito, Michela, primary, Marzullo, Aldo, additional, Leone, Riccardo, additional, Zaffino, Paolo, additional, Steffanoni, Sara, additional, Erbella, Federico, additional, Calimeri, Francesco, additional, Anzalone, Nicoletta, additional, De Momi, Elena, additional, Ferreri, Andrés J. M., additional, Calimeri, Teresa, additional, and Spadea, Maria Francesca, additional

Published
2023
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38. Cerebral hyperdensity on CT imaging (CTHD) post-reperfusion treatment in patients with acute cerebral stroke: understanding its clinical meaning

Author

Calloni, Sonia Francesca, Panni, Pietro, Calabrese, Francesca, Del Poggio, Anna, Roveri, Luisa, Squarza, Silvia, Pero, Guglielmo Carlo, Paolucci, Aldo, Filippi, Massimo, Falini, Andrea, Anzalone, Nicoletta, Calloni, Sonia Francesca, Panni, Pietro, Calabrese, Francesca, Del Poggio, Anna, Roveri, Luisa, Squarza, Silvia, Pero, Guglielmo Carlo, Paolucci, Aldo, Filippi, Massimo, Falini, Andrea, and Anzalone, Nicoletta

Subjects
Stroke, Brain parenchymal hyperdensities, Treatment Outcome, CT imaging, Reperfusion, Humans, Radiology, Nuclear Medicine and imaging, Reperfusion therapy, General Medicine, Anterior circulation stroke, Tomography, X-Ray Computed, Brain Ischemia, Retrospective Studies
Abstract

Objectives To investigate the clinical meaning of brain parenchymal computed-tomography hyperdensities (CTHD) in patients treated of anterior circulation acute stroke with reperfusion therapy.Methods Patients were retrospectively enrolled from three different hospitals. Brain CT scans were assessed at four time points: We recorded ASPECT scores of pre-treatment CTs, assessed ASPECT scores and the presence of CTHD on posttreatment CTs acquired within 24-30 h and 24-72 h, and examined a one-month CTs follow-up to determine the ischemic evolution of CTHD. We correlated the presence of CTHD with clinical and radiological data to define its predictive and prognostic factors.Results In total, 165 patients were evaluated. At post-treatment CTs acquired within 24-30 h, 68 (41%) patients showed the presence of CTHD. On post-treatment CTs acquired within 24-72 h, 43 (63%) of the CTHD showed hemorrhagic transformation. Sixty-five (95%) out of the 68 CTHD evolved in a final ischemic brain area. Multivariate statistical analysis identified puncture to recanalization time to be the only independent factors predicting the presence of CTHD (p = 0.045). The presence of CTHD at the first post-treatment CTs was an independent factor for clinical outcome determined with mRS scores at 3-month follow-up (p = 0.05). Outcomes were worse for hemorrhagic transformation at follow-up CTs compared to the ischemic evolution of the CTHD (p = 0.01).Conclusions The presence of CTHD at CTs imaging acquired within 24-30 h after reperfusion therapy is an independent prognostic factor of a worse clinical outcome, regardless of its ASPECT score at baseline CTs and of its hemorrhagic evolution.

Published
2021

41. Intracranial MR Angiography

Author

Anzalone, Nicoletta, Tartaro, Armando, Schneider, Günther, editor, Prince, Martin R., editor, Meaney, James F. M., editor, and Ho, Vincent B., editor

Published
2005
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42. Radiomics-based machine learning model for predicting Overall and Progression-Free Survival in rare cancer: a case study for Primary CNS Lymphoma patients

Author

Destito, Michela, primary, Marzullo, Aldo, additional, Leone, Riccardo, additional, Zaffino, Paolo, additional, Steffanoni, Sara, additional, Erbella, Federico, additional, Calimeri, Francesco, additional, Anzalone, Nicoletta, additional, De Momi, Elena, additional, Ferreri, Andrés J.M., additional, Calimeri, Teresa, additional, and Spadea, Maria Francesca, additional

Published
2022
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43. Decoding the Heterogeneity of Malignant Gliomas by PET and MRI for Spatial Habitat Analysis of Hypoxia, Perfusion, and Diffusion Imaging: A Preliminary Study

Author

Bailo, Michele, primary, Pecco, Nicolò, additional, Callea, Marcella, additional, Scifo, Paola, additional, Gagliardi, Filippo, additional, Presotto, Luca, additional, Bettinardi, Valentino, additional, Fallanca, Federico, additional, Mapelli, Paola, additional, Gianolli, Luigi, additional, Doglioni, Claudio, additional, Anzalone, Nicoletta, additional, Picchio, Maria, additional, Mortini, Pietro, additional, Falini, Andrea, additional, and Castellano, Antonella, additional

Published
2022
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45. Cerebral neoplastic enhancing lesions: Multicenter, randomized, crossover intraindividual comparison between gadobutrol (1.0 M) and gadoterate meglumine (0.5 M) at 0.1 mmol Gd/kg body weight in a clinical setting

Author

Anzalone, Nicoletta, Scarabino, Tommaso, Venturi, Carlo, Cristaudo, Concetto, Tartaro, Armando, Scotti, Giuseppe, Zimatore, Domenico, Floris, Roberto, Carriero, Alessandro, Longo, Marcello, Cirillo, Mario, Cova, Maria Assunta, Gatti, Simona, Voth, Matthias, and Colosimo, Cesare

Published
2013
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46. Decoding the Heterogeneity of Malignant Gliomas by PET and MRI for Spatial Habitat Analysis of Hypoxia, Perfusion, and Diffusion Imaging: A Preliminary Study

Author

Bailo, M, Pecco, N, Callea, M, Scifo, P, Gagliardi, F, Presotto, L, Bettinardi, V, Fallanca, F, Mapelli, P, Gianolli, L, Doglioni, C, Anzalone, N, Picchio, M, Mortini, P, Falini, A, Castellano, A, Bailo, Michele, Pecco, Nicolò, Callea, Marcella, Scifo, Paola, Gagliardi, Filippo, Presotto, Luca, Bettinardi, Valentino, Fallanca, Federico, Mapelli, Paola, Gianolli, Luigi, Doglioni, Claudio, Anzalone, Nicoletta, Picchio, Maria, Mortini, Pietro, Falini, Andrea, Castellano, Antonella, Bailo, M, Pecco, N, Callea, M, Scifo, P, Gagliardi, F, Presotto, L, Bettinardi, V, Fallanca, F, Mapelli, P, Gianolli, L, Doglioni, C, Anzalone, N, Picchio, M, Mortini, P, Falini, A, Castellano, A, Bailo, Michele, Pecco, Nicolò, Callea, Marcella, Scifo, Paola, Gagliardi, Filippo, Presotto, Luca, Bettinardi, Valentino, Fallanca, Federico, Mapelli, Paola, Gianolli, Luigi, Doglioni, Claudio, Anzalone, Nicoletta, Picchio, Maria, Mortini, Pietro, Falini, Andrea, and Castellano, Antonella

Abstract

Background: Tumor heterogeneity poses major clinical challenges in high-grade gliomas (HGGs). Quantitative radiomic analysis with spatial tumor habitat clustering represents an innovative, non-invasive approach to represent and quantify tumor microenvironment heterogeneity. To date, habitat imaging has been applied mainly on conventional magnetic resonance imaging (MRI), although virtually extendible to any imaging modality, including advanced MRI techniques such as perfusion and diffusion MRI as well as positron emission tomography (PET) imaging. Objectives: This study aims to evaluate an innovative PET and MRI approach for assessing hypoxia, perfusion, and tissue diffusion in HGGs and derive a combined map for clustering of intra-tumor heterogeneity. Materials and Methods: Seventeen patients harboring HGGs underwent a pre-operative acquisition of MR perfusion (PWI), Diffusion (dMRI) and 18F-labeled fluoroazomycinarabinoside (18F-FAZA) PET imaging to evaluate tumor vascularization, cellularity, and hypoxia, respectively. Tumor volumes were segmented on fluid-attenuated inversion recovery (FLAIR) and T1 post-contrast images, and voxel-wise clustering of each quantitative imaging map identified eight combined PET and physiologic MRI habitats. Habitats’ spatial distribution, quantitative features and histopathological characteristics were analyzed. Results: A highly reproducible distribution pattern of the clusters was observed among different cases, particularly with respect to morphological landmarks as the necrotic core, contrast-enhancing vital tumor, and peritumoral infiltration and edema, providing valuable supplementary information to conventional imaging. A preliminary analysis, performed on stereotactic bioptic samples where exact intracranial coordinates were available, identified a reliable correlation between the expected microenvironment of the different spatial habitats and the actual histopathological features. A trend toward a higher representation of

Published
2022

48. In Reply: Clinical Impact and Predictors of Aneurysmal Rebleeding in Poor-Grade Subarachnoid Hemorrhage: Results From the National POGASH Registry

Author

Panni, Pietro, Ambrosi, Alessandro, Riccio, Lucia, Cao, Roberta, Alessandra Barzaghi, Lina Raffaella, Da Passano, Camillo Ferrari, Donofrio, Carmine Antonio, Albano, Luigi, Simionato, Franco, Scomazzoni, Francesco, Caterina, Michelozzi, Anzalone, Nicoletta, Dell’Acqua, Antonio, Calvi, Maria Rosa, Cozzi, Silvano, Azzolini, Maria Luisa, Zotti, Margherita, Pedicelli, Alessandro, Marchese, Enrico, Caricato, Anselmo, Alexandre, Andrea, Valente, Iacopo, Di Bonaventura, Rina, Grilli, Fulvio, Scavone, Angela, Pisapia, Luca, Gelormini, Camilla, Feletti, Alberto, Testa, Mattia, Zanatta, Paolo, Mauro, Luigi, Liviero, Marilena Casartelli, Venza, Alessia, Robbi, Helena, Piva, Simone, Gitti, Nicola, Mardighian, Dikran, Latronico, Nicola, Rasulo, Frank A., Semeraro, Vittorio, Nardin, Giordano, Marrazzo, Antonio, Burdi, Nicola, Ganimede, Maria Porzia, Cacciapaglia, Michele, Lozupone, Emilio, Paiano, Gianfranco, Paladini, Adriana, Pauciulo, Alfredo, Mastria, Donatella, Pulito, Giuseppe, Picetti, Edoardo, Petranca, Massimo, Montanaro, Vito, Menozzi, Roberto, Cerasti, Davide, Giombelli, Ermanno, Bortolotti, Carlo, Scibilia, Nino, Cirillo, Luigi, Aspide, Raffaele, Castioni, Carlo Alberto, Lanterna, Andrea Luigi, Bernucci, Claudio, Costi, Emanuele, and Fanti, Andrea

Published
2023
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