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42 results on '"Anzalone, Anthony"'

5. Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study

Author

Sarma, Anand Karthik, primary, Popli, Gautam, additional, Anzalone, Anthony, additional, Contillo, Nicholas, additional, Cornell, Cassandra, additional, Nunn, Andrew M., additional, Rowland, Jared A., additional, Godwin, Dwayne W., additional, Flashman, Laura A., additional, Couture, Daniel, additional, and Stapleton-Kotloski, Jennifer R., additional

Published
2023
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16. Transcranial ultrasonography to detect intracranial pathology: A systematic review and meta‐analysis.

Author

Allen, Beddome C., Kapoor, Sahil, Anzalone, Anthony, Mayer, Kirby P., Wolfe, Stacey Q., Duncan, Pam, Asimos, Andrew W., D'Agostino, Ralph, Winslow, James Tripp, and Sarwal, Aarti

Subjects
TRANSCRANIAL Doppler ultrasonography, CINAHL database, DIAGNOSTIC ultrasonic imaging, MEDICAL subject headings
Abstract

Background and Purpose: Transcranial ultrasonography (TCU) can be a useful diagnostic tool in evaluating intracranial pathology in patients with limited or delayed access to routine neuroimaging in critical care or austere settings. We reviewed available literature investigating the diagnostic utility of TCU for detecting pediatric and adult patient's intracranial pathology in patients with intact skulls and reported diagnostic accuracy measures. Methods: We performed a systematic review of PubMed®, Cochrane Library, Embase®, Scopus®, Web of Science™, and Cumulative Index to Nursing and Allied Health Literature databases to identify articles evaluating ultrasound‐based detection of intracranial pathology in comparison to routine imaging using broad Medical Subject Heading sets. Two independent reviewers reviewed the retrieved articles for bias using the Quality Assessment of Diagnostic Accuracy Studies tools and extracted measures of diagnostic accuracy and ultrasound parameters. Data were pooled using meta‐analysis implementing a random‐effects approach to examine the sensitivity, specificity, and accuracy of ultrasound‐based diagnosis. Results: A total of 44 studies out of the 3432 articles screened met the eligibility criteria, totaling 2426 patients (Mean age: 60.1 ± 14.52 years). We found tumors, intracranial hemorrhage (ICH), and neurodegenerative diseases in the eligible studies. Sensitivity, specificity, and accuracy of TCU and their 95% confidence intervals were 0.80 (0.72, 0.89), 0.71 (0.59, 0.82), and 0.76 (0.71, 0.82) for neurodegenerative diseases; 0.88 (0.74, 1.02), 0.81 (0.50, 1.12), and 0.94 (0.92, 0.96) for ICH; and 0.97 (0.92, 1.03), 0.99 (0.96, 1.01), and 0.99 (0.97, 1.01) for intracranial masses. No studies reported ultrasound presets. Conclusions: TCU has a reasonable sensitivity and specificity for detecting intracranial pathology involving ICH and tumors with clinical applications in remote locations or where standard imaging is unavailable. Future studies should investigate ultrasound parameters to enhance diagnostic accuracy in diagnosing intracranial pathology. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Abstract 11502: Elevations in Proinflammatory Cytokines Il-1β and Il-12 in the Transgenic (mren2)27 Rat: A Clinically-Relevant Animal Model of Metabolic Syndrome

Author

McMullen, Nathan P, primary, Contillo, Nicholas, additional, Wolfe, Stacey, additional, Ryalat, Fatima, additional, Anzalone, Anthony, additional, Coffman, Stephanie, additional, Tschoe, Christine, additional, DIZ, Debra I, additional, xiang, zhidan, additional, Peterson, Keyan, additional, and Jestus, Jack, additional

Published
2021
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21. Blood Biomarkers of Sports-Related Concussion in Pediatric Athletes

Author

Anzalone, Anthony J., primary, Turner, Stephanie M., additional, Baleztena, Angela C., additional, McGuffin, Tiffany, additional, Creed, Kalyssa, additional, Jeromin, Andreas, additional, Wilson, David, additional, Hanlon, David, additional, Garrison, J. Craig, additional, Blueitt, Damond, additional, and Oliver, Jonathan M., additional

Published
2021
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26. Probiotic administration increases amino acid absorption from plant protein – A placebo‐controlled, randomized, double‐blind, multicenter, crossover study

Author

Zaragoza, Javier Andres, primary, Urbina, Stacie, additional, Purpura, Martin, additional, Jaeger, Ralf, additional, Tinsley, Grant, additional, Anzalone, Anthony, additional, Stone, Jason, additional, Askow, Andrew T, additional, Oliver, Jonathan M, additional, Fiore, Walter, additional, Biffi, Andrea, additional, and Taylor, Lem, additional

Published
2020
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29. The Omega-3 Index in National Collegiate Athletic Association Division I Collegiate Football Athletes

Author

Anzalone, Anthony, primary, Carbuhn, Aaron, primary, Jones, Lauren, primary, Gallop, Ally, primary, Smith, Alex, primary, Johnson, Palmer, primary, Swearingen, Lisa, primary, Moore, Craig, primary, Rimer, Ernest, primary, McBeth, Joe, primary, Harris, William, primary, Kirk, K. Michelle, primary, Gable, David, primary, Askow, Andrew, primary, Jennings, Will, primary, and Oliver, Jonathan M., primary

Published
2019
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31. A Positive Vestibular/Ocular Motor Screening (VOMS) Is Associated With Increased Recovery Time After Sports-Related Concussion in Youth and Adolescent Athletes

Author

Anzalone, Anthony J., primary, Blueitt, Damond, additional, Case, Tami, additional, McGuffin, Tiffany, additional, Pollard, Kalyssa, additional, Garrison, J. Craig, additional, Jones, Margaret T., additional, Pavur, Robert, additional, Turner, Stephanie, additional, and Oliver, Jonathan M., additional

Published
2016
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32. Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise

Author

Jäger, Ralf, primary, Purpura, Martin, additional, Stone, Jason, additional, Turner, Stephanie, additional, Anzalone, Anthony, additional, Eimerbrink, Micah, additional, Pane, Marco, additional, Amoruso, Angela, additional, Rowlands, David, additional, and Oliver, Jonathan, additional

Published
2016
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35. Interceptive Activity of Azastene in Rhesus Monkeys**Presented in part at the Ninth World Congress on Fertility and Sterility and the Thirty-Third Annual Meeting of The American Fertility Society, April 12 to 16, 1977 Miami Beach, Fla.

Author

Schane, H.P., Creange, John E., Anzalone, Anthony J., and Potts, Gordon O.

Abstract

Azastene is an orally effective “luteolytic” agent in rhesus monkeys. In nonpregnant monkeys it reverses the human chorionic gonadotropin-stimulated increase in progesterone production and delay in the onset of menstruation, and in inseminated monkeys, it prevents pregnancy if given for 5 days beginning on day 24 of the menstrual cycle. The drug is also effective in terminating pregnancy if given for 5 days beginning on approximately day 26, day 50, or day 80 of gestation. Concurrent progesterone administration prevents the interceptive action of the drug. Although azastene inhibits gonadal and placental progesterone production, it has no effect on cortisol production in monkeys and is devoid of apparent hormonal activity.

Published
1978
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36. Interruption of Pregnancy in Rats by Azastene, an Inhibitor of Ovarian and Adrenal Steroidogenesis**Presented in part at the Ninth World Congress on Fertility and Sterility and the Thirty-Third Annual Meeting of The American Fertility Society, April 12 to 16, 1977, Miami Beach, Fla.

Author

Creange, John E., Schane, H.P., Anzalone, Anthony J., and Potts, Gordon O.

Abstract

Azastene (4,4,17α-trimethylandrost-5-eno [2,3-d]isoxazol-17-ol), when given orally to rats at a dose of 12 mg/kg once on day 10 of pregnancy, induced resorption of all fetuses and a precipitous decline of circulating progesterone levels in all test animals. The disruption of pregnancy was prevented by a single, concurrent, subcutaneous injection of progesterone (4 mg/rat). Thus, the interruption of pregnancy occurs via an acute, short-term, reversible progesterone withdrawal. The reduction of progesterone levels is brought about by competitive inhibition of ovarian 3β-hydroxysteroid dehydrogenase activity. Despite its potency as an interceptive agent, azastene exhibited only moderate endocrine-related effects if given daily for 2 weeks to female rats at doses as high as 1000 mg/kg. Those effects were an increase in the number of vaginal estrous days and a dose-related increase in adrenal weight. The latter effect is consistent with the known adrenal inhibitory properties of this drug.

Published
1978
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42. Fluctuations in blood biomarkers of head trauma in NCAA football athletes over the course of a season.

Author

Oliver JM, Anzalone AJ, Stone JD, Turner SM, Blueitt D, Garrison JC, Askow AT, Luedke JA, and Jagim AR

Abstract

Objective: Repetitive subconcussive head trauma is a consequence of participation in contact sports and may be linked to neurodegenerative diseases. The degree of neurological injury caused by subconcussive head trauma is not easily detectible, and this injury does not induce readily identifiable clinical signs or symptoms. Recent advancements in immunoassays make possible the detection and quantification of blood biomarkers linked to head trauma. Identification of a blood biomarker that can identify the extent of neurological injury associated with subconcussive head trauma may provide an objective measure for informed decisions concerning cumulative exposure to subconcussive head trauma. The purpose of the current study was to examine changes in the blood biomarkers of subconcussive head trauma over the course of an American football season., Methods: Thirty-five National Collegiate Athletic Association (NCAA) American football athletes underwent blood sampling throughout the course of a football season. Serial samples were obtained throughout the 2016 season, during which the number and magnitude of head impacts changed. Blood samples were analyzed for plasma concentrations of tau and serum concentrations of neurofilament light polypeptide (NF-L). Athletes were grouped based on their starter status, because athletes identified as starters are known to sustain a greater number of impacts. Between-group differences and time-course differences were assessed., Results: In nonstarters, plasma concentrations of tau decreased over the course of the season, with lower values observed in starters; this resulted in a lower area under the curve (AUC) (starters: 416.78 ± 129.17 pg/ml/day; nonstarters: 520.84 ± 163.19 pg/ml/day; p = 0.050). Plasma concentrations of tau could not be used to discern between starters and nonstarters. In contrast, serum concentrations of NF-L increased throughout the season as head impacts accumulated, specifically in those athletes categorized as starters. The higher serum concentrations of NF-L observed in starters resulted in a larger AUC (starters: 1605.03 ± 655.09 pg/ml/day; nonstarters: 1067.29 ± 272.33 pg/ml/day; p = 0.007). The AUC of the receiver operating characteristic curve analyses displayed fair to modest accuracy to identify athletes who were starters with the use of serum NF-L following periods of repetitive impacts., Conclusions: The different patterns observed in serum NF-L and plasma tau concentrations provide preliminary evidence for the use of blood biomarkers to detect the neurological injury associated with repetitive subconcussive head trauma. Although further investigation is necessary, such findings might lay the foundation for the further development of an objective measure for the detection of neurological injury caused by subconcussive head trauma.

Published
2018
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