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Your search keyword '"Antunez, Lorena R."' showing total 11 results
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11 results on '"Antunez, Lorena R."'

3. Demonstration of Tunable Control over a Delayed-Release Vaccine Using Atomic Layer Deposition.

Author

Brubaker, Sky W., Walters, Isabella R., Hite, Emily M., Antunez, Lorena R., Palm, Emma L., Funke, Hans H., and Steadman, Bryan L.

Subjects
ATOMIC layer deposition, PATIENT compliance, ANTIBODY formation, VACCINATION, VACCINES
Abstract

Many vaccines require multiple doses for full efficacy, posing a barrier for patient adherence and protection. One solution to achieve full vaccination may be attained with single-administration vaccines containing multiple controlled release doses. In this study, delayed-release vaccines were generated using atomic layer deposition (ALD) to coat antigen-containing powders with alumina. Using in vitro and in vivo methods, we show that increasing the coat thickness controls the kinetics of antigen release and antibody response, ranging from weeks to months. Our results establish an in vitro–in vivo correlation with a level of tunable control over the antigen release and antibody response times with the potential to impact future vaccine design. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Stabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine

Author

Kumru, Ozan S., primary, Saleh-Birdjandi, Soraia, additional, Antunez, Lorena R., additional, Sayeed, Eddy, additional, Robinson, David, additional, van den Worm, Sjoerd, additional, Diemer, Geoffrey S., additional, Perez, Wilma, additional, Caposio, Patrizia, additional, Früh, Klaus, additional, Joshi, Sangeeta B., additional, and Volkin, David B., additional

Published
2019
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