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590 results on '"Antunes, Alberto A."'

2. Evaluation of AR, AR-V7, and p160 family as biomarkers for prostate cancer: insights into the clinical significance and disease progression

Author

Pimenta, Ruan, Malulf, Feres Camargo, Romão, Poliana, Caetano, Giovana Vilas Boas, da Silva, Karina Serafim, Ghazarian, Vitoria, dos Santos, Gabriel A., Guimarães, Vanessa, Silva, Iran Amorim, de Camargo, Juliana Alves, Recuero, Saulo, Melão, Bárbara V. Lima Aguiar, Antunes, Alberto Azoubel, Srougi, Miguel, Nahas, William, Leite, Katia R. M., and Reis, Sabrina T.

Published
2024
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4. Bonding positional accuracy of attachments and marginal adaptation of in‐house aligners – A quality improvement laboratory study.

Author

Brandão, Nathália Moraes Carvalho Barreto, Maia, Raiane Machado, Gomes, Victor de Morais, Resende, Carolina, Antunes, Alberto Nogueira da Gama, and Souki, Bernardo Quiroga

Subjects
ORTHODONTIC appliances, LAMINATED plastics, POLYETHYLENE terephthalate, CARTESIAN coordinates, THREE-dimensional printing
Abstract

Objectives: To evaluate the 3D accuracy of attachment positioning and the adaptation of aligners to attachments using in‐house templates made with either polyethylene terephthalate glycol (PETG) or ethylene‐vinyl acetate (EVA) and either pressure or vacuum thermoforming machines. Materials and Methods: Overall, 140 test specimens were resin‐printed. Templates for the attachment bonding were made with 1‐mm EVA or 0.5‐mm PETG laminates. Orthodontic aligners were manufactured with 0.75‐mm PETG. The thermoplastification process was carried out using either vacuum or pressure machines. The positional differences between the virtual and bonded attachments were assessed in the X, Y and Z coordinates. The marginal adaptation between the aligners and the attachments was measured. Results: Minor inaccuracies in the positioning of the attachments were observed in all combinations of thermoforming machines and plastic laminates used to fabricate the templates, mainly in the superior–inferior (Z) dimension. PETG performed better than EVA in the anterior region (p <.05). No association was found between thermoplastification machines and the accuracy of the positioning of the attachments (p >.05). While small misadaptations between the aligners and the attachments were observed, the EVA templates performed better than the PETG templates. Conclusions: The inaccuracy of the attachment positioning and the misadaptation of the aligners to the attachments were slight. The vacuum and pressure thermoplastification machines showed no difference in attachment positioning accuracy. The PETG template was better than the EVA template in the anterior region, but the EVA attachments presented a better adaptation to the aligners than the PETG attachments. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Downregulation of PIEZO2 in the Detrusor of Men With Bladder Outlet Obstruction and Its Association With Urinary Retention and Decreased Bladder Compliance.

Author

Bellucci, Carlos Henrique Suzuki, Hemerly, Thiago Souto, Albuquerque, Luisa Resende Tenório de, Pimenta, Ruan, Schreiter, Vanessa Guimaraes, Reis, Sabrina Thalita dos, Jr, Jose de Bessa, Leite, Katia Ramos Moreira, Antunes, Alberto, Boopathi, Ettickan, Nahas, William C., and Gomes, Cristiano Mendes

Subjects
BLADDER obstruction, URINARY organs, BENIGN prostatic hyperplasia, BLADDER diseases, BLADDER
Abstract

Purpose: Recent research has highlighted the mechanotransducer PIEZO2 as a crucial factor in lower urinary tract function, demonstrating associations with bladder compliance (BC), bladder wall thickening, and elevated bladder pressure. We explored the hypothesis that PIEZO2 expression may be associated with lower urinary tract dysfunction in men with bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH). Methods: The study included a consecutive series of patients undergoing open prostatectomy for BPH at our hospital between September 2014 and January 2016. All participants underwent comprehensive preoperative evaluations, including urodynamic assessments. During prostatectomy, a full-thickness fragment of the bladder wall was obtained for subsequent PIEZO2 gene expression analysis. Cadaveric organ donors served as the control group. Results: PIEZO2 expression was downregulated in the detrusor muscle of men with BPH compared to the control group. Among patients with BPH, those experiencing urinary retention and requiring an indwelling catheter exhibited significantly lower PIEZO2 messenger RNA (mRNA) expression than patients capable of spontaneous voiding. PIEZO2 mRNA expression was similar in men with and without detrusor overactivity. Additionally, a positive correlation was found between PIEZO2 mRNA expression levels and BC. Conclusions: Our findings indicate that PIEZO2 is downregulated in the detrusor muscle of men with BPH, particularly in those experiencing urinary retention and those with reduced BC. These results suggest a potential role for PIEZO2 in BOOinduced bladder dysfunction. Further research is required to clarify the role of PIEZO mechanotransducers in the bladder and to explore their therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Viability of Maxillary Single Crowns Supported by 4-mm Short Implants: A Finite Element Study.

Author

Capatti, Rodrigo Souza, Barboza, Marcela Silva, Antunes, Alberto Nogueira da Gama, Oliveira, Dauro Douglas, and Seraidarian, Paulo Isaías

Subjects
DENTAL crowns, DENTAL implants, MAXILLA, BIOMECHANICS, FINITE element method, MECHANICAL loads, PHYSIOLOGICAL stress, DENTAL abutments
Abstract

Short implants are increasingly being used in posterior regions to avoid grafting procedures and their related risks, costs, and morbidity. However, studies focusing on implants measuring less than 6 mm long remain scarce, and the literature does not yet have a definition of the limits inherent with their use. This study attempts to investigate whether extra-short 4-mm implants are capable of receiving a maxillary single crown. Materials and Methods: This study evaluates, through the finite element method, the stress distribution generated at implant lengths of 4 mm and 10 mm caused by different crown heights (10, 12.5, and 15 mm) in the posterior maxilla region when submitted to axial (200 N) and oblique (100 N) loads. Results: The 4-mm implant showed a similar level of performance as that of the 10-mm implant when submitted to the axial load. However, the oblique load proved to be highly detrimental to both implants, inducing stresses of up to three times higher than those achieved in conjunction with the axial load, especially in the surrounding bone and the abutment. Conclusion: The use of 4-mm short implants to support single crowns in the posterior maxilla region may be feasible in habitual conditions; however, the risk associated with significant oblique loads should be mitigated by adopting a mutually protected occlusion approach and using acrylic occlusal devices if necessary. I [ABSTRACT FROM AUTHOR]

Published
2020
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32. Biaxial Flexural Strength of Direct Composite Resins Using Different Light-Curing Times and Post-Cure Method.

Author

Gomes Machado, Manuela Regina, de Souza Lima, Larissa Costa, Isaias Seraidarian, Paulo, Rocha Pereira, Guilherme, Lage Martins, Camilla, and da Gama Antunes, Alberto Nogueira

Subjects
FLEXURAL strength, DISTILLED water, DENTAL adhesives
Abstract

The aim of this study was to evaluate the biaxial flexural strength of four composite resins of different compositions, light-cured in two stages, and then, post-cure using heat and pressure. There were made 480 composite resin disks, being 120 disks each one. Of these 120 disks, 60 were light-cured for 20 seconds, the other 60 for 60 seconds. Then, half of each photoactivated group (n = 30) was subjected to post-cure using heat and pressure and the other half (n = 30) was not. Next, the disks were stored in distilled water for 24 hours before testing. After the statistical analysis, it was found that the composite Z100 and Filtek Z350 had a higher value of biaxial flexural strength in the groups of 20 and 60 seconds in the conventional method. In the condition of 20 seconds post-cure, the highest values are achieved by Z100 (18.65 MPa) and Filtek Z350 (24.71 MPa). While in the condition of 60 seconds post-cure the best result was achieved with the Z100 (64.88 MPa) and the lowest value was the IPS Empress Direct (7.56 MPa). There was a statistically significant decrease in biaxial flexural strength in the Z100 that received the light curing for 20 seconds and post-cure (18.65 MPa), when compared to conventional polymerization (28.29 MPa). Therefore, there is no need to light-cure the composites exceeding the manufacturers recommended time, in the conventional method. The post-cure protocol promoted increase in biaxial flexural strength only for the Z100 light-cured for 60 seconds. [ABSTRACT FROM AUTHOR]

Published
2023

37. Tgf-β1 expression as a biomarker of poor prognosis in prostate cancer

Author

dos Reis, Sabrina Thalita, Pontes-Júnior, José, Antunes, Alberto Azoubel, de Sousa-Canavez, Juliana Moreira, Abe, Daniel Kanda, da Cruz, José Arnaldo Shiomi, Dall'Oglio, Marcos Francisco, Crippa, Alexandre, Passerotti, Carlo Camargo, Ribeiro-Filho, Leopoldo A, Viana, Nayara Izabel, Srougi, Miguel, and Leite, Kátia Ramos Moreira

Published
2011
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44. Analysis of prognostic factors in patients with transitional cell carcinoma of the bladder treated with radical cystectomy

Author

Antunes Alberto A., Nesrallah Luciano J., Dall'Oglio Marcos F., Ferreira Yuri A., Passerotti Carlo C., Leite Katia R., Ortiz Valdemar, and Srougi Miguel

Subjects
bladder neoplasms, transitional cell, cystectomy, prognosis, Diseases of the genitourinary system. Urology, RC870-923
Abstract

OBJECTIVE: To analyze the results of the treatment of transitional cell carcinoma (TCC) of the bladder with radical cystectomy and determine which prognostic factors can be utilized as disease-free survival and cancer-specific survival independent variables. MATERIALS AND METHODS: Medical records of 113 patients submitted to radical cystectomy and bilateral iliac lymphadenectomy between 1993 and 2005 were reviewed. The risk factors analyzed were age, sex, pathological stage, tumor grade, presence of carcinoma in situ and the presence of lymph nodes involvement. RESULTS: After a mean follow-up of 31.7 ? 28.5 months, 46 patients (40.7%) presented recurrence and 24 patients (21.2%) died due to cancer. Only pathological stage and the lymph nodes involvement became independent variables for recurrence and survival. Patients with T4 stage presented 9.6 times the risk of recurrence of the disease when compared with stage T0 patients (p = 0.010) and the patients with lymph node involvement presented 2.5 times the risk of recurrence (p = 0.047) and 3.1 times the risk of death (p = 0.022) when compared to patients without lymph nodes involvement. CONCLUSIONS: Pathological stage and the involvement of lymph nodes represented more important prognostic variables, and in the presence of advanced stage tumors (T3/T4) and involvement of lymph nodes, the institution of adjuvant treatment should be considered.

Published
2006

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