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1. Novel Darknet traffic data synthesis using Generative Adversarial Networks enhanced with oscillatory Growing Cosine Unit activated convolution layers

Author

Antony Pradeep C, Geraldine Bessie Amali D, Mathew Mithra Noel, Muhammad Rukunuddin Ghalib, Prabhakar Rontala Subramaniam, and Chitra Venugopal

Subjects
Darknet, Cyber security, Network detection systems, Generative adversarial networks, Feature selection, Growing cosine unit, Electronic computers. Computer science, QA75.5-76.95, Science
Abstract

The Darknet is an anonymous, encrypted collection of websites, with a passive listening nature - accepting incoming packets, while not supporting outgoing packets. Thus, it can potentially host criminal or malicious activity and software, becoming a cyber security threat. Network Detection Systems are effective in identifying dark net traffic and mitigating its ill effects. However, capturing and extracting data from raw network traffic for training these systems can be time-intensive and costly. Using the CIC-Darknet 2020 dataset, this paper proposes using a Novel Generative Adversarial Networks (GAN) Architecture generating the required training and testing data for these systems. This uses a combination of Growing Cosine Unit (GCU) activated convolution layers and Dense layers for the Generator. Feature selection with statistical correlation methods is used to select the most relevant features. An independently trained Evaluator network is used to evaluate the generated data. The proposed system is compared to other established Tabular data GANs like Conditional Tabular GAN (CTGAN) and Copula GAN with similar parameters and on the same data. The Proposed GAN architecture outperforms CTGAN and CopulaGAN by 20 % and 10 % in ters of accuracy while also taking 90 % and 30 % less time to train respectively. Results from measuring similarity of data using the Inverted Kolmogorov - Smirnov D statistic also show significantly better results for the Proposed GAN Architecture. This shows significant promise in using Generative models to reduce the time and effort costs associated with collecting and formatting data to use in research and for training detection systems.

Published
2024
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4. Unseen Abyss: Implementation of Pothole Detection System Using Machine Learning

Author

Biju, Emmanuel Davis, Antony, Grigary C., Thottappilly, Fabius S., Davis, Disan, Babu, Anju, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Pandian, A. Pasumpon, editor, Palanisamy, Ram, editor, Narayanan, M., editor, and Senjyu, Tomonobu, editor

Published
2022
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7. Occurrence, virulence, and AMR profile of Vibrio parahaemolyticus isolated from shellfish growing areas located along the south-west coast of India.

Author

Antony, Ally C., Silvester, Reshma, Aneesa, P. A., P. V., Vipindas, Selvam A., Deborah Gnana, Salim, Vivas, Paul, Mini K., and Abdulla, Mohamed Hatha

Subjects
*VIBRIO parahaemolyticus, *DRUG resistance in microorganisms, *DRUG resistance in bacteria, *WATER sampling, *GASTROENTERITIS, *SHELLFISH
Abstract

Vibrio parahaemolyticus is a leading cause of human gastroenteritis associated with seafood consumption. The present study aimed to investigate the occurrence and risk assessment of V. parahaemolyticus isolated from live Indian black clams, sediment, and water samples collected from shellfish harvesting areas located along the south-west coast of India. Out of the total 72 samples collected, 55.6% revealed the presence of V. parahaemolyticus; the highest occurrence was observed in shellfish samples. The presence of tdh and trh virulence genes was screened by multiplex PCR. Virulence genes could be detected in 25.8% of the strains; 19.35% of them were trh positive and 3.2% were tdh positive, while 3.2% of strains exhibited the coexistence of both virulence genes. Antimicrobial resistance (AMR) determined by the disk diffusion method revealed that 87% of the strains were multiple drug resistant and exhibited 21 diverse resistance patterns. The overall multiple antibiotic resistance (MAR) index values ranged from 0 to 0.8. To the best of our knowledge, this is the first report to document the presence of pathogenic and multidrug-resistant V. parahaemolyticus in shellfish harvesting areas of the Indian sub-continent. The study reveals possible health hazards associated with consuming shellfish harvested from the study area. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Prediction of glassy silica etching with hydrogen fluoride gas by kinetic Monte Carlo simulations.

Author

Park, Hyunhang, Antony, Andrew C., Banerjee, Joy, Smith, Nicholas J., and Agnello, Gabriel

Subjects
*MONTE Carlo method, *HYDROGEN fluoride, *CHALCOGENIDE glass, *ETCHING, *SURFACE phenomenon
Abstract

Understanding the surface properties of glass during the hydrogen fluoride (HF)-based vapor etching process is essential to optimize treatment processes in semiconductor and glass industries. In this work, we investigate an etching process of fused glassy silica by HF gas with kinetic Monte Carlo (KMC) simulations. Detailed pathways of surface reactions between gas molecules and the silica surface with activation energy sets are explicitly implemented in the KMC algorithm for both dry and humid conditions. The KMC model successfully describes the etching of the silica surface with the evolution of surface morphology up to the micron regime. The simulation results show that the calculated etch rate and surface roughness are in good agreement with the experimental results, and the effect of humidity on the etch rate is also confirmed. Development of roughness is theoretically analyzed in terms of surface roughening phenomena, and it is predicted that the values of growth and roughening exponents are 0.19 and 0.33, respectively, suggesting that our model belongs to the Kardar–Parisi–Zhang universality class. Furthermore, the temporal evolution of surface chemistry, specifically surface hydroxyls and fluorine groups, is monitored. The surface density of fluorine moieties is 2.5 times higher than that of the hydroxyl groups, implying that the surface is well fluorinated during vapor etching. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Glycaemic control and microvascular complications among paediatric type 2 diabetes mellitus patients in Hong Kong at 2 years after diagnosis.

Author

Yam, W. I., Wong, Shirley M. Y., Cheung, P. T., Kwan, Elaine Y. W., Lam, Y. Y., Wong, L. M., Ng, K. L., Wong, Sammy W. C., Lee, C. Y., Tay, M. K., Chan, K. T., Fu, Antony C. C., Tung, Joanna Y. L., Pang, Gloria S. W., Yau, H. C., See, Queenie W. S., Lo, Priscilla W. C., To, Sharon W. Y., Yuen, H. W., and Chung, Jacky Y. K.

Published
2024
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13. Ambient Cured Geopolymer Concrete Products

Author

Thirugnanasambandam, S., Antony Jeyasehar, C., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Solari, Giovanni, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Das, Bibhuti Bhusan, editor, and Neithalath, Narayanan, editor

Published
2019
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14. An Intelligent Fault Locator for 400-kV Double-Circuit Line of Chhattisgarh State: A Comparative Study

Author

Ashok, V., Yadav, A., Antony, C. C., Yadav, K. K., Yadav, U. K., Sahu, Sandeep Kumar, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Nayak, Janmenjoy, editor, Abraham, Ajith, editor, Krishna, B. Murali, editor, Chandra Sekhar, G. T., editor, and Das, Asit Kumar, editor

Published
2019
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26. Spaces of appearance : writings on contemporary theatre and performance

Author

Williams, Antony David C.

Subjects
792.01
Abstract

This thesis, a collection of previously published materials, reflects a plural and evolving engagement with theatre and performance over the past fifteen years or so: as researcher, writer, editor, teacher, practitioner, spectator. These have rarely been discreet categories for me, but rather different modalities of exploration and enquiry, interrelated spaces encouraging dynamic connectivities, flows and further questions. Section 1 offers critical accounts of the practices of four contemporary theatre directors: Jerzy Grotowski, Robert Wilson, Peter Brook and Ariane Mnouchkine. Section 2 draws on elements of contemporary philosophy and critical thinking to explore the mutable parameters of performance. lt proposes performative mappings of certain unpredictable, energetic events 'in proximity of performance', to borrow Matthew Goulish's phrase: contact, fire, animals, alterity, place. Section 3 contains examples of documentation of performance practices, including a thick description of a mise en scene of a major international theatre production, reflections on process, training and dramaturgy, a performance text with a framing dramaturgical statement, and personal perspectives on particular collaborations. The external Appendix comprises a recently published collection of edited and translated materials concerning five core collaborative projects realised by Ariane Mnouchkine and the Theatre du Soleil at their base in the Cartoucherie de Vincennes, Paris. The core concerns of this thesis include attempts to think through: • the working regimes, poetics and pedagogies of certain directors, usually in collaborative devising contexts within which the creative agency of performers is privileged; • the processes and micro-politics of collaboration, devising, and dramaturgical composition; the dramaturgical implications of trainings, narrative structures, spaces, mise en scene, and of images as multi-layered, dynamic 'fields'; • the predicament and agency of spectators in diverse performance contexts, and the ways in which spectatorial roles are posited or constructed by dramaturgies; • the imbrication of embodiment, movement and perception in performance, and the plurality of modes of perception; • the critical and political functions of theatre and theatre criticism as cultural/social practice and 'art of memory' (de Certeau), of dramaturgies as critical historiographies, and of theatre cultures (and identities) as plural, dynamic, and contested; • performance as concentrated space for inter-subjectivity and the flaring into appearance of the 'face-to-face' (Levinas); the possibility of ethical, 'response-able' encounter and exchange with another; identity as relational and in-process, alterity as productive event, the inter-personal as political; • the poetics and politics of what seems an unthinkable surplus (and constitutive 'outside') to the cognitive reach of many conventional frames and maps in theatre criticism and historiography; an exploration of acts of writing as performative propositions and provocations ('critical fictions') to think the event of meanings at/of the limits of knowledge and subjectivity. This partial listing of recurrent and evolving concerns within the thesis traces a trajectory in my evolution as a writer and thinker, a gradual displacement from the relatively 'solid ground' of theatre studies and theatre history towards more fluid and tentative articulations of the shifting 'lie of the land' in contemporary performance and philosophy. This trajectory reflects a growing fascination with present process, conditions, practices, perceptions 'in the middle', and ways of writing (about) performance as interactive and ephemeral event.

Published
2002

29. Analysis of Residential Building by Monitoring, Resource Allocation and Cost Optimization Using Construction Management Tool

Author

Antony, Jubin C., Shah, Rinni, Antony, Jubin C., and Shah, Rinni

Abstract

This research focuses on the construction project management of a residential development including amenities like landscaping, clubhouse, recreational area and commercial, this involves directing and organizing each part of the project life cycle, from ideation to completion. Project management is the coordinating effort to fulfill the goals of the project, an art of balancing project objectives against the constraints of time, budget, and quality. Achieving that balance requires skill, experience, and techniques. This project report focuses on the planning and scheduling of residential apartment buildings in Oracle Primavera construction management tool. Project monitoring, resource allocation and cost optimization of study area is done using Oracle Primavera P6.

Published
2023

33. Contributors

Author

Abdel-Wahab, Omar, primary, Abrahm, Janet L., additional, Adams, Sharon, additional, Adewoye, Adeboye H., additional, Allen, Carl, additional, Ambinder, Richard F., additional, Anasetti, Claudio, additional, Anastasi, John, additional, Anderson, Julia A., additional, Antin, Joseph H., additional, Antony, Aśok C., additional, Araten, David J., additional, Armand, Philippe, additional, Armstrong, Gillian, additional, Armstrong, Scott A., additional, Arnold, Donald M., additional, Artz, Andrew S., additional, Awan, Farrukh T., additional, Baglin, Trevor P., additional, Benson, Don M., additional, Benz, Edward J., additional, Berliner, Nancy, additional, Bhagat, Govind, additional, Bhardwaj, Nina, additional, Bhatia, Ravi, additional, Bhatia, Smita, additional, Bhatt, Mihir D., additional, Bhatt, Vijaya Raj, additional, Bitan, Menachem, additional, Blinderman, Craig D., additional, Bollard, Catherine M., additional, Braun, Benjamin S., additional, Brenner, Malcolm K., additional, Brittenham, Gary M., additional, Brodsky, Robert A., additional, Brown, Myles, additional, Broxmeyer, Hal E., additional, Brummel-Ziedins, Kathleen, additional, Brunner, Andrew M., additional, Buadi, Francis K., additional, Burkhardt, Birgit, additional, Burns, Melissa, additional, Byrd, John C., additional, Caimi, Paolo F., additional, Caligiuri, Michael A., additional, Canavan, Michelle, additional, Cantor, Alan B., additional, Carcao, Manuel, additional, Carroll, Michael C., additional, Carty, Shannon A., additional, Castillo, Jorge J., additional, Chan, Anthony K.C., additional, Chapin, John, additional, Chiu, April, additional, Chute, John P., additional, Clark, David B., additional, Coates, Thomas D., additional, Cogle, Christopher R., additional, Connell, Nathan T., additional, Cooke, Elizabeth, additional, Cooley, Sarah, additional, Corradini, Paolo, additional, Creager, Mark A., additional, Creger, Richard J., additional, Cromwell, Caroline, additional, Crowther, Mark A., additional, Cushing, Melissa M., additional, Cutler, Corey, additional, Dang, Chi V., additional, Danial, Nika N., additional, Dave, Sandeep S., additional, DeCaprio, James A., additional, Dinauer, Mary C., additional, Dinner, Shira, additional, Diz-Küçükkaya, Reyhan, additional, Dodd, Roger Y., additional, Donato, Michele L., additional, Dorshkind, Kenneth, additional, Dotti, Gianpietro, additional, Dror, Yigal, additional, Dunleavy, Kieron, additional, Dvorak, Christopher C., additional, Ebert, Benjamin L., additional, Eck, Michael J., additional, Eikelboom, John W., additional, Epperla, Narendranath, additional, Ershler, William B., additional, Evans, William E., additional, Faderl, Stefan, additional, Ferrara, James L.M., additional, Filipovich, Alexandra Hult, additional, Fischer, Martin, additional, Fredenburgh, James C., additional, Friedman, Kenneth D., additional, Fuchs, Ephraim, additional, Fuller, Stephen J., additional, Gailani, David, additional, Galipeau, Jacques, additional, Gallagher, Patrick G., additional, Ganapathi, Karthik A., additional, Gardner, Lawrence B., additional, Gee, Adrian P., additional, Gerson, Stanton L., additional, Gertz, Morie A., additional, Giardina, Patricia J., additional, Gibson, Christopher J., additional, Golan, Karin, additional, Golub, Todd R., additional, Gonzales, Matthew J., additional, Gotlib, Jason, additional, Gottschalk, Stephen, additional, Grant, Marianne A., additional, Graubert, Timothy A., additional, Gregg, Xylina T., additional, Gribben, John G., additional, Gross, Dawn M., additional, Gruber, Tanja A., additional, Guitart, Joan, additional, Gurbuxani, Sandeep, additional, Gur-Cohen, Shiri, additional, Gutierrez, Alejandro, additional, Hamadani, Mehdi, additional, Hari, Parameswaran N., additional, Hartwig, John H., additional, Hayman, Suzanne R., additional, Hayward, Catherine P.M., additional, Hebbel, Robert P., additional, Heslop, Helen E., additional, Hillis, Christopher, additional, Hillyer, Christopher D., additional, Ho, Karin, additional, Hockenbery, David M., additional, Hoffman, Ronald, additional, Hogg, Kerstin E., additional, Holtan, Shernan G., additional, Horny, Hans-Peter, additional, Hsu, Yen-Michael S., additional, Hunter, Zachary R., additional, Huntington, James A., additional, Iancu-Rubin, Camelia, additional, Iqbal, Ali, additional, Isenman, David E., additional, Israels, Sara J., additional, Italiano, Joseph E., additional, Jaffe, Elaine S., additional, Jaffer, Iqbal H., additional, Jagannath, Sundar, additional, Jäger, Ulrich, additional, Jain, Nitin, additional, James, Paula, additional, Jeha, Sima, additional, Jordan, Michael B., additional, Josephson, Cassandra D., additional, Jung, Moonjung, additional, Kager, Leo, additional, Kambayashi, Taku, additional, Kanakry, Jennifer A., additional, Kantarjian, Hagop M., additional, Kaplan, Jason, additional, Karafin, Matthew S., additional, Karsan, Aly, additional, Kaufman, Randal J., additional, Kaufman, Richard M., additional, Keller, Frank G., additional, Kelly, Kara M., additional, Kessler, Craig M., additional, Key, Nigel S., additional, Keyzner, Alla, additional, Khandoga, Alexander G., additional, Khanna-Gupta, Arati, additional, Khatib-Massalha, Eman, additional, Klein, Harvey G., additional, Knoechel, Birgit, additional, Kollet, Orit, additional, Konkle, Barbara A., additional, Kontoyiannis, Dimitrios P., additional, Koreth, John, additional, Koretzky, Gary A., additional, Kotecha, Dipak, additional, Kremyanskaya, Marina, additional, Kumari, Anju, additional, Kuzel, Timothy M., additional, Küppers, Ralf, additional, Lacy, Martha Q., additional, Ladas, Elana, additional, Landier, Wendy, additional, Lapid, Kfir, additional, Lapidot, Tsvee, additional, Larson, Peter J., additional, Levi, Marcel, additional, Lewis, Russell E., additional, Liebman, Howard A., additional, Lillicrap, David, additional, Lim, Wendy, additional, Lin, Judith C., additional, Lindblad, Robert, additional, Lip, Gregory Y.H., additional, Little, Jane A., additional, Lohr, Jens G., additional, López, José A., additional, Luscinskas, Francis W., additional, Maciejewski, Jaroslaw P., additional, Majhail, Navneet S., additional, Manches, Olivier, additional, Mandle, Robert J., additional, Mann, Kenneth G., additional, Manno, Catherine S., additional, Marcogliese, Andrea N., additional, Mariani, Guglielmo, additional, Marincola, Francesco M., additional, Mascarenhas, John, additional, Massberg, Steffen, additional, McEver, Rodger P., additional, McGrath, Emer, additional, McKinney, Matthew S., additional, Mehta, Rohtesh S., additional, Mentzer, William C., additional, Merlini, Giampaolo, additional, Merryman, Reid, additional, Michel, Marc, additional, Migliaccio, Anna Rita, additional, Miller, Jeffrey S., additional, Mims, Martha P., additional, Mondoro, Traci Heath, additional, Moorehead, Paul, additional, Muniz, Luciana R., additional, Munshi, Nikhil C., additional, Najfeld, Vesna, additional, Nayak, Lalitha, additional, Nazy, Ishac, additional, Neff, Anne T., additional, Ness, Paul M., additional, Notarangelo, Luigi D., additional, O'Brien, Sarah H., additional, O'Connor, Owen A., additional, O'Donnell, Martin, additional, Olson, Amanda, additional, Orkin, Stuart H., additional, Pai, Menaka, additional, Pai, Sung-Yun, additional, Paidas, Michael, additional, Panch, Sandhya R., additional, Pande, Reena L., additional, Papayannopoulou, Thalia, additional, Parikh, Rahul, additional, Petersdorf, Effie W., additional, Peterson, Shane E., additional, Pittaluga, Stefania, additional, Ponce, Doris M., additional, Popolo, Laura, additional, Prchal, Josef T., additional, Pui, Ching-Hon, additional, Puigserver, Pere, additional, Rak, Janusz, additional, Ramos, Carlos A., additional, Rand, Jacob H., additional, Rand, Margaret L., additional, Rao, Dinesh S., additional, Ravandi, Farhad, additional, Rawlings, David J., additional, Reddy, Pavan, additional, Reding, Mark T., additional, Reiter, Andreas, additional, Rice, Lawrence, additional, Riese, Matthew J., additional, Ritchey, Arthur Kim, additional, Roberts, David J., additional, Roman, Elizabeth, additional, Rooney, Cliona M., additional, Rosen, Steven T., additional, Rosenthal, David S., additional, Rossmann, Marlies P., additional, Rot, Antal, additional, Rowley, Scott D., additional, Rubnitz, Jeffrey E., additional, Rydz, Natalia, additional, Salama, Mohamed E., additional, Sauk, Steven, additional, Saunthararajah, Yogen, additional, Savage, William, additional, Scadden, David, additional, Schaefer, Kristen G., additional, Schiffman, Fred, additional, Schneidewend, Robert, additional, Schrier, Stanley L., additional, Schuchman, Edward H., additional, Scullion, Bridget Fowler, additional, Selvaggi, Kathy J., additional, Senoo, Keitaro, additional, Shaheen, Montaser, additional, Shaz, Beth H., additional, Shelburne, Samuel A., additional, Shpall, Elizabeth J., additional, Shurin, Susan B., additional, Siegal, Deborah, additional, Silberstein, Leslie E., additional, Silberstein, Lev, additional, Silverstein, Roy L., additional, Sloan, Steven R., additional, Smith, Franklin O., additional, Smith, James W., additional, Smith, Katy, additional, Steensma, David P., additional, Steinberg, Martin H., additional, Stock, Wendy, additional, Storry, Jill R., additional, Stramer, Susan L., additional, Strauss, Ronald G., additional, Stroncek, David F., additional, Taylor, Justin, additional, Thota, Swapna, additional, Treon, Steven P., additional, Tulpule, Anil, additional, Valdes, Roberto Ferro, additional, Valent, Peter, additional, Vedantham, Suresh, additional, Vercellotti, Gregory M., additional, Verneris, Michael R., additional, Vichinsky, Elliott P., additional, von Andrian, Ulrich H., additional, Vose, Julie M., additional, Wagner, Andrew J., additional, Wang, Ena, additional, Wang, Jia-huai, additional, Warkentin, Theodore E., additional, Wasserstein, Melissa P., additional, Webster, Ann, additional, Weisdorf, Daniel J., additional, Weitz, Jeffrey I., additional, Westhoff, Connie M., additional, Wheeler, Allison P., additional, Widick, Page, additional, Wiley, James S., additional, William, Basem M., additional, Williams, David A., additional, Wilson, Wyndham H., additional, Wolfe, Joanne, additional, Wolgast, Lucia R., additional, Wood, Deborah, additional, Wu, Jennifer, additional, Yahalom, Joachim, additional, Yee, Donald L., additional, Younes, Anas, additional, Young, Neal S., additional, and Zeller, Michelle P., additional

Published
2018
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35. Electronic charge transfer during metal/SiO2 contact: Insight from density functional theory.

Author

Antony, Andrew C., Thelen, Dean, Zhelev, Nikolay, Adib, Kaveh, and Manley, Robert G.

Subjects
*CHARGE transfer, *DENSITY functional theory, *ELECTRONIC density of states, *TRANSITION metals, *ATOMIC models, *FERMI level
Abstract

Contact charging of hydroxylated SiO2/metal interfaces is studied using density functional theory calculations. Atomic scale models are generated for hydroxylated α-cristobalite interfaced with three different fcc metals: Al, Pt, and Au. Regions of electron accumulation and depletion are highest in magnitude near the SiO2/Pt and SiO2/Au interfaces and lower at the SiO2/Al interface. One key finding of this work is that the presence of a metal surface near the hydroxylated SiO2 induces electronic states at the SiO2 surface within the apparent insulating bandgap. The magnitude of these states is highest for Pt and Au contacts and lowest for Al, indicating that the amount of charge transfer at the interface trends with the density of electronic defect states. Such electronic defect states reside near the fermi level of the system and it is proposed that these states from surface oxygen atoms are at least partly responsible for the electronic charge transfer mechanism between a metal and an insulator. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Deletion of the AMPylase mFICD alters cytokine secretion and affects cognitive plasticity in vivo

Author

Corey M. Porter, Hidde L. Ploegh, Nicholas McCaul, Matthias C. Truttmann, Antony Tang C, Bhaskar K. Chatterjee, Becker A, Charlotte Wijne, Angelina M. Bilate, Djenet Bousbaine, and Chih-Chi Andrew Hu

Subjects
biology, In vivo, Chemistry, Chaperone (protein), Protein biosynthesis, biology.protein, Unfolded protein response, Cytokine secretion, Secretion, Acquired immune system, Function (biology), Cell biology
Abstract

Fic domain-containing AMP transferases (fic AMPylases) are conserved enzymes that catalyze the covalent transfer of AMP to proteins. This post-translational modification regulates the function of several proteins, including the ER-resident chaperone Grp78/BiP. Here we introduce a mFICD AMPylase knock-out mouse model to study fic AMPylase function in vertebrates. We find that mFICD deficiency is well-tolerated in unstressed mice. We show that mFICD-deficient mouse embryonic fibroblasts are depleted of AMPylated proteins. mFICD deletion alters protein synthesis and secretion in splenocytes, including that of IgM and IL-1β, without affecting the unfolded protein response. Finally, we demonstrate that older mFICD-/- mice show improved cognitive plasticity. Together, our results suggest a role for mFICD in adaptive immunity and neuronal plasticity in vivo.

Published
2021

49. Review on the Screening of Urine Glucose in School Children and Adolescents With Obesity for Early Diagnosis of Type 2 Diabetes Mellitus in Hong Kong

Author

Pang, Gloria S W, primary, Lee, Ching-Yin, additional, Fu, Antony C C, additional, Tsang, Jennifer Wing-Yan, additional, Yau, Kent H C, additional, Belaramani, Kiran, additional, Wong, Lap Ming, additional, But, Betty W M, additional, Chow, Jasmine C K, additional, Wong, Shirley M Y, additional, Cheung, Patrick C H, additional, Lo, Priscilla W C, additional, Ng, Kwok- Leung, additional, Tung, Joanna Y L, additional, Poon, Sarah W Y, additional, Chan, Kwong Tat, additional, Chan, Angela M K, additional, Wong, Sammy W C, additional, Tay, Ming-Kut, additional, Chung, Ying Ki, additional, Lam, Yuen Yu, additional, and Kwan, Elaine Y W, additional

Published
2021
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