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Aim: To investigate size of the aortal root and its valves in young patients and correlation between tricuspid aortal valve (TAV) asymmetry and connective tissue dysplasia (CTD)., Material and Methods: TAV symmetry was studied in young patients. Morphological examination consisted in phenotypic study of 34 corpses of young people who had died of noncardiological causes with a focus to internal signs of CTD signs and measurements of TAV and each cusp. Echocardiographic examination comprised phenotypic, clinical and echocardiographic studies of 144 young patients., Results: Echocardiographic diagnostic criteria of TAV asymmetry were specified. They consisted in eccentricity of the line of diastolic closure of aortal cusp (M-mode echocardiography) > 1.2; distinct differences in the size of the cusps (two-dimentional study), shift of at least one of the comissures by I hour at the "clock-face". A close correlation was detected between TA V asymmetry, external and clinical manifestations of CTD. The morphological criterion of TA V asymmetry--a more than 38% increase in the ratio of cusp area to sectional area of aortal root., Conclusion: TAV asymmetry is detected in 20% young people. It is closely related to external signs and clinical manifestations of CTD, other minor heart anomalies and may be accompanied with aortal regurgitation.

The experimental work performed in 6 dogs was aimed at studying the dynamics of morphological alterations of the interatrial septum (IAS) tissues in the place of occlusion of the endovascular appliance ("ASO") and around it on the right and left atrium side at different terms after operation. A defect of the animals' interatrial septum in the area of the oval fossa was modeled artificially and then abolished with the "ASO". No substantial differences were revealed between processes of organization of thrombotic masses and formation of the endothelium on the "ASO" from both atria. The endothelium on the micropreparations on the "ASO" surfaces was formed as early as by the 14th day after its implantation in the heart IAS.