153 results on '"Antonio Montefusco"'
Search Results
2. Prognostic Impact of Nutritional Status After Transcatheter Edge‐to‐Edge Mitral Valve Repair: The MIVNUT Registry
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Berenice Caneiro‐Queija, Sergio Raposeiras‐Roubin, Marianna Adamo, Xavier Freixa, Dabit Arzamendi, Tomas Benito‐González, Antonio Montefusco, Isaac Pascual, Luis Nombela‐Franco, Josep Rodes‐Cabau, Mony Shuvy, Antonio Portolés‐Hernández, Cosmo Godino, Dan Haberman, Laura Lupi, Ander Regueiro, Chin Hion Li, Felipe Fernández‐Vázquez, Simone Frea, Pablo Avanzas, Gabriela Tirado‐Conte, Jean‐Michel Paradis, Alona Peretz, Vanessa Moñivas, Jose A. Baz, Michele Galasso, Luca Branca, Laura Sanchís, Lluís Asmarats, Carmen Garrote‐Coloma, Filippo Angelini, Victor León, José A. de Agustín, Alberto Alperi, Ronen Beeri, Gloria Maccagni, Manel Sabaté, Estefanía Fernández‐Peregrina, Javier Gualis, Pier Paolo Bocchino, Salvatore Curello, Andrés Íñiguez‐Romo, and Rodrigo Estévez‐Loureiro
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CONUT ,heart failure ,malnutrition ,mortality ,transcatheter edge‐to‐edge repair ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Malnutrition is associated with poor prognosis in several cardiovascular diseases. However, its prognostic impact in patients undergoing transcatheter edge‐to‐edge mitral valve repair (TEER) is not well known. This study sought to assess the prevalence, clinical associations, and prognostic consequences of malnutrition in patients undergoing TEER. Methods and Results A total of 892 patients undergoing TEER from the international MIVNUT (Mitral Valve Repair and Nutritional Status) registry were studied. Malnutrition status was assessed with the Controlling Nutritional Status score. The association of nutritional status with mortality was analyzed with multivariable Cox regression models, whereas the association with heart failure admission was assessed by Fine‐Gray models, with death as a competing risk. According to the Controlling Nutritional Status score, 74.4% of patients with TEER had any degree of malnutrition at the time of TEER (75.1% in patients with body mass index
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- 2022
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3. Peculiar Ca2+ Homeostasis, ER Stress, Autophagy, and TG2 Modulation in Celiac Disease Patient-Derived Cells
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Silvia Sposito, Agnese Secondo, Antonio Massimiliano Romanelli, Antonio Montefusco, Merlin Nanayakkara, Salvatore Auricchio, Maria Vittoria Barone, Ivana Caputo, and Gaetana Paolella
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celiac disease ,Ca2+ homeostasis ,type 2 transglutaminase ,unfolded protein response ,ER stress ,autophagy ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Celiac disease (CD) is an inflammatory intestinal disease caused by the ingestion of gluten-containing cereals by genetically predisposed individuals. Constitutive differences between cells from CD patients and control subjects, including levels of protein phosphorylation, alterations of vesicular trafficking, and regulation of type 2 transglutaminase (TG2), have been reported. In the present work, we investigated how skin-derived fibroblasts from CD and control subjects responded to thapsigargin, an endoplasmic reticulum ER stress inducer, in an attempt to contribute to the comprehension of molecular features of the CD cellular phenotype. We analyzed Ca2+ levels by single-cell video-imaging and TG2 activity by a microplate assay. Western blots and PCR analyses were employed to monitor TG2 levels and markers of ER stress and autophagy. We found that the cytosolic and ER Ca2+ level of CD cells was lower than in control cells. Treatments with thapsigargin differently activated TG2 in control and CD cells, as well as caused slightly different responses regarding the activation of ER stress and the expression of autophagic markers. On the whole, our findings identified further molecular features of the celiac cellular phenotype and highlighted that CD cells appeared less capable of adapting to a stress condition and responding in a physiological way.
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- 2023
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4. Echocardiographic estimation of right ventricular wall tension: haemodynamic comparison and long-term follow-up
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Umberto Annone, Pier P. Bocchino, Walter G. Marra, Fabrizio D’Ascenzo, Corrado Magnino, Antonio Montefusco, Pierluigi Omedè, Franco Veglio, Alberto Milan, and Gaetano M. de Ferrari
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
Prognosis in pulmonary hypertension is strictly linked to right ventricle failure, which results from uncoupling between right ventricle function and its afterload. This study sought to describe how to estimate with echocardiography right ventricular wall tension, its correlation with right ventricle haemodynamics and its prognostic role. A total of 190 patients without overt right ventricle failure but with suspected pulmonary hypertension on a previous echocardiogram underwent right heart catheterization and nearly-simultaneous echocardiography. Right ventricular wall tension was estimated according to Laplace’s law as right ventricle length × tricuspid regurgitation peak gradient and it was correlated with right ventricle haemodynamic profile; its potential prognostic impact was tested along with canonical right ventricle function parameters. Right ventricular wall tension correlated significantly with invasive estimation of right ventricle end-diastolic pressure (R: 0.343, p
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- 2019
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5. Prime osservazioni su «Ars dictaminis», cultura volgare e distribuzione sociale dei saperi nella Toscana medievale.
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Antonio Montefusco and Sara Bischetti
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Ars dictaminis ,ars arengandi ,retorica ,rhetoric ,oratoria ,oratory ,traduzione ,translation ,volgarizzamento ,vulgarization ,latinizzazione ,latinisation ,Philology. Linguistics ,P1-1091 - Abstract
Intento di questo contributo è quello di studiare l’ars dictaminis in rapporto alla diffusione del fenomeno della traduzione nella Toscana medievale (secc. XIII-XV). In particolare, l’articolo mette in discussione la vulgata storiografica che individua un “eccezionalismo” della regione in ragione dell’estensione del fenomeno dei volgarizzamenti nonché nella capacità di sottrarsi ai dettami della tradizione tipicamente mediolatina del dictamen producendo una retorica di impianto oratorio incentrata sull’uso del volgare. Dopo una breve panoramica degli studi sul dictamen degli ultimi anni, viene studiato il rapporto tradictamen e volgare in due contesti, che sono stati scelti per la loro vicinanza e differenza: Bologna e Firenze. Di quest’ultima si è tentato di fornire le linee-guida dell’influsso del dictamen in particolare in un autore (Brunetto Latini) che è solitamente considerato particolarmente eversivo nell’uso e nella concezione della retorica; si è quindi passati a verificare la permanenza del modello retorico-dictaminale imposto da Brunetto, grazie all’apporto di fonti estranee all’ars (in particolare Albertano da Brescia), nel XIV secolo, misurandone la consistenza in una linea che da Andrea Lancia porta al notaio episcopale Francesco da Barberino. Ne risultano, quindi, due modelli differenti – uno bolognese, uno fiorentino – che emergono come tali anche nelle scelte librarie della tradizione manoscritta, che viene analizzata nell’ultimo paragrafo. The purpose of this contribution is to study the ars dictaminis in relation to the diffusion of the phenomenon of translation in medieval Tuscany (XIII-XV centuries). In particular, the article calls into question the vulgate which identifies an “exceptionalism” of the region due to the extension of the phenomenon of vulgarization as well as the ability to escape the dictates of the latin tradition of dictamen producing an oratory focused on use of the vernacular. After a brief overview of the recent literature on the dictamen, the relationship between this latter and the affirmation of the vernacular is studied in two contexts, Bologna and Florence. Such a comparaison has provided the guidelines for studying the influence of the dictamen, particularly in an author (Brunetto Latini) who is usually considered to be particularly subversive in the use and conception of rhetoric; we then proceeded to verify the permanence of the rhetorical model imposed by Brunetto, thanks to the contribution of other sources (in particular Albertano from Brescia), in the fourteenth century, measuring its consistency in a line that led by Andrea Lancia to the episcopal notary Francesco da Barberino. The result is two different models - one from Bologna, one from Florence - which emerge as such also in the manuscript tradition, that is analyzed in the last paragraph.
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- 2018
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6. La linea Guittone-Monte e la nuova parola poetica
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Antonio Montefusco
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Guittone d’Arezzo ,Monte Andrea ,Guido Orlandi ,Roman de la Rose ,Fiore ,Detto d’Amore ,Archaeology ,CC1-960 ,Medieval history ,D111-203 ,Language and Literature - Abstract
L’articolo ricostruisce la storia intellettuale della poesia toscana del Duecento. In particolare, l’analisi individua nelle opere (poesie e lettere) e nella biografia (dalla vita politica alla conversione religiosa) di Guittone d’Arezzo un progetto culturale alternativo a quello di Brunetto Latini, in concorrenza con le rivoluzioni di Popolo e in stretta relazione con l’azione dei frati Gaudenti. La tradizione letteraria successiva si confronta con questa eredità in maniera critica. A parte il rifiuto di Dante, largamente studiato nella letteratura critica, vengono qui analizzate le risposte di Monte Andrea (anni ’70-’80) e degli intellettuali fiorentini negli anni ’90.
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- 2017
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7. Dante attraverso i documenti. II. Presupposti e contesti dell’impegno politico a Firenze (1295-1302)
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Giuliano Milani (a cura di) and Antonio Montefusco (a cura di)
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dante alighieri ,firenze ,politica ,Archaeology ,CC1-960 ,Medieval history ,D111-203 ,Language and Literature - Abstract
La sezione monografica comprende dodici articoli volti a investigare il significato del breve impegno di Dante Alighieri nelle istituzioni politiche fiorentine avvenuto tra 1295 e 1302. Un primo blocco di testi (i contributi di E. Faini, A. Montefusco, P. Borsa, M. Grimaldi) dà conto dei presupposti di tale impegno, analizzando le valenze politiche della formazione culturale e poetica dei fiorentini alla fine del Duecento. Un secondo gruppo di contributi (di L. Tanzini, E. Brilli e A. Zorzi) indaga il contesto istituzionale e politico di quegli anni alla luce delle fonti normative e cronachistiche. Infine un terzo insieme di saggi (di D. Cappi, D. Carron, P. Gualtieri e D. Bortoluzzi) Dante e Firenze vengono comparati con comuni cittadini e personaggi ad essi legati. Conclude la sezione un saggio di G. Milani in cui, anche alla luce delle indagini raccolte, la documentazione relativa all’impegno politico del poeta è sottoposta a un complessivo riesame.
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- 2017
8. «Prescindendo dai versi di Dante»? Un percorso negli studi tra testi, biografia e documenti
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Giuliano Milani and Antonio Montefusco
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Dante Alighieri ,Codice diplomatico dantesco ,critica dantesca ,Michele Barbi ,Gianfranco Contini ,Archaeology ,CC1-960 ,Medieval history ,D111-203 ,Language and Literature - Abstract
L’articolo si concentra sul posto che i documenti raccolti nel Codice diplomatico dantesco ha avuto nella storia degli studi danteschi nell’arco dell’ultimo secolo. Questa storia è scandita in tre quadri, il primo incentrato sul centenario del 1921 e sulla figura di Michele Barbi; la seconda fase, dominata da Gianfranco Contini, è collocata intorno al centenario della morte nel 1965; l’ultima fase è quella più recente. Il rapporto degli studiosi con i documenti è stato incostante, ed è cambiato in relazione a fattori molteplici, tra cui il rapporto tra i vari campi disciplinari e le generazioni degli studiosi e il loro rapporto reciproco, anche politico. Sulla base del nuovo interesse per le fonti documentarie che emerge negli studî più recenti, gli autori propongono di tornare a studiare più da vicino e con strumenti nuovi i documenti che riguardano Dante e la sua famiglia, cercando di fare attenzione a non far interferire troppo lo studio dei documenti con l’autonarrazione che Dante propone della sua biografia.
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- 2014
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9. Dante attraverso i documenti. I. Famiglia e patrimonio (secolo XII-1300 circa)
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Giuliano Milani (a cura di) and Antonio Montefusco (a cura di)
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Archaeology ,CC1-960 ,Medieval history ,D111-203 ,Language and Literature - Abstract
I contribuiti qui riuniti sono il risultato di un workshop che si è tenuto alla Sapienza di Roma il 20 e il 21 settembre 2013 dal titolo: Intorno al Codice diplomatico dantesco I. I documenti sulla famiglia e il patrimonio di Dante. In quell’occasione alcuni storici medievisti sono stati invitati a ragionare su un corpus definito di documenti riguardanti Dante Alighieri e la sua famiglia, editi nel Codice diplomatico dantesco curato da Renato Piattoli nel 1940, poi aggiornato, e oggi in via di allargamento e revisione. I documenti in questione sono stati selezionati prendendo come termine di arrivo gli anni del diretto impegno politico di Dante a Firenze (1295-1302), in modo da avviare una discussione sui temi della famiglia Alighieri, delle sue reti sociali, della sua condizione economica. Nel corso di questa discussione da italianisti e storici medievisti sono state proposte nuove piste metodologiche e nuove interpretazioni dei dati disponibili, sempre nel quadro di un fecondo incontro fra discipline.
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- 2014
10. Francesco da Barberino al crocevia: Culture, società, bilinguismo
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Sara Bischetti, Antonio Montefusco, Sara Bischetti, Antonio Montefusco and Sara Bischetti, Antonio Montefusco, Sara Bischetti, Antonio Montefusco
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- 2021
11. Toscana bilingue (1260 ca.–1430 ca.): Per una storia sociale del tradurre medievale
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Sara Bischetti, Michele Lodone, Cristiano Lorenzi, Antonio Montefusco, Sara Bischetti, Michele Lodone, Cristiano Lorenzi, Antonio Montefusco and Sara Bischetti, Michele Lodone, Cristiano Lorenzi, Antonio Montefusco, Sara Bischetti, Michele Lodone, Cristiano Lorenzi, Antonio Montefusco
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- 2021
12. Le lettere di Dante: Ambienti culturali, contesti storici e circolazione dei saperi
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Antonio Montefusco, Giuliano Milani, Antonio Montefusco, Giuliano Milani and Antonio Montefusco, Giuliano Milani, Antonio Montefusco, Giuliano Milani
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- 2020
13. Nicole Bériou, Jacques Dalarun et Dominique Poirel (dir.), Le manuscrit franciscain retrouvé, Paris, CNRS Éditions, 2021, 394 p
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Antonio Montefusco
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History ,General Social Sciences - Published
- 2022
14. Italia senza nazione: Lingue, culture, conflitti tra Medioevo ed età contemporanea
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AA.VV., Antonio Montefusco and AA.VV., Antonio Montefusco
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- 2019
15. In-hospital outcomes in nonagenarian patients undergoing primary percutaneous coronary intervention
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Filippo ANGELINI, Luca FRANCHIN, Pier P. BOCCHINO, Nuccia MORICI, Wojciech WAŃHA, Stefano SAVONITTO, Daniela TRABATTONI, Enrico CERRATO, Lucia BARBIERI, Federico FORTUNI, Leonardo DE LUCA, Antonio GRECO, Ovidio DE FILIPPO, Antonio MONTEFUSCO, Andrea MONTABONE, Anna E. RUBINO, Sebastiano GILI, Giorgio QUADRI, Alberto SOMASCHINI, Stefano CORNARA, Stefano CARUGO, Davide CAPODANNO, Wojciech WOJAKOWSKI, Veronica DUSI, Fabrizio D’ASCENZO, and Gaetano M. DE FERRARI
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Cardiology and Cardiovascular Medicine - Abstract
The aim of the present analysis was to evaluate the incidence and predictors of in-hospital adverse outcomes in nonagenarian patients undergoing primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI).Consecutive nonagenarian patients undergoing pPCI for STEMI from 2009 to 2019 were retrospectively included in an international multicenter registry. In-hospital all-cause death was the primary outcome.A total of 308 patients were included (mean age 92.5±2.5 years, 65.6% female). Mean systolic blood pressure (SBP) at hospital admission was 130.7±33.5 mmHg, 46 (17%) patients presented with a Killip class III-IV, mean left ventricle ejection fraction (LVEF) was 40.0±11.5% and 147 (58%) patients were independent in everyday activities. In-hospital death occurred in 99 patients (32%). After multivariate adjustment, lower LVEF (OR per unit reduction 1.08, 95% CI: 1.03-1.11, P value0.001), lower SBP (OR 1.02 per mmHg reduction, 95% CI: 1.01-1.03, P value 0.001) and being not independent at home (OR 2.56, 95% CI: 1.25-5.26, P value 0.01) resulted independent predictors of in-hospital mortality. A sensitivity analysis performed in final TIMI 3 flow population confirmed the prognostic role of LVEF and independency on in-hospital mortality.Nonagenarian patients presenting with STEMI and undergoing pPCI have high in-hospital mortality. Independency in everyday life is a strong independent predictor of survival to hospital discharge.
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- 2022
16. Long-term (≥15 years) Follow-up of Percutaneous Coronary Intervention of Unprotected Left Main (From the GRAVITY Registry)
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Christian Templin, Filippo Figini, Roberto Manfredi, O De Filippo, Alessandra Truffa, Carlo Andrea Pivato, Fabio Infusino, Federico Conrotto, Antonio Montefusco, Edoardo Elia, Gianni Casella, Roi Estevez, Sebastiano Gili, G. Biondi Zoccai, Marek Milewski, G. Di Palma, Giulio G. Stefanini, Bernardo Cortese, Daniela Trabattoni, Guglielmo Gallone, G M De Ferrari, Giorgio Marengo, Pierluigi Omedè, S. Raporeiras Roubin, Imad Sheiban, Andrzej Ochała, Roberto Verardi, Massimo Mancone, R. González Ferreiro, Veronica Dusi, Wojciech Wańha, Fabrizio D'Ascenzo, and Wojciech Wojakowski
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medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Coronary Artery Disease ,Coronary Angiography ,Risk Assessment ,Percutaneous Coronary Intervention ,Risk Factors ,Internal medicine ,medicine ,Humans ,Registries ,cardiovascular diseases ,Aged ,Ejection fraction ,business.industry ,Percutaneous coronary intervention ,Middle Aged ,Coronary Vessels ,Europe ,Survival Rate ,medicine.anatomical_structure ,Cohort ,Conventional PCI ,Etiology ,Cardiology ,Unselected population ,Cardiology and Cardiovascular Medicine ,business ,aged ,coronary angiography ,coronary artery disease ,coronary vessels ,europe ,follow-up studies ,humans ,middle aged ,percutaneous coronary intervention ,risk assessment ,risk factors ,survival rate ,forecasting ,registries ,Follow-Up Studies ,Forecasting ,Artery - Abstract
Long term survival and its determinants after Percutaneous Coronary Intervention (PCI) on Unprotected Left Main Coronary Artery (ULMCA) remain to be appraised. In 9 European Centers 470 consecutive patients performing PCI on ULMCA between 2002 and 2005 were retrospectively enrolled. Survival from all cause and cardiovascular (CV) death were the primary end points, while their predictors at multivariate analysis the secondary ones. Among the overall cohort 81.5% of patients were male and mean age was 66 ± 12 years. After 15 years (IQR 13 to 16), 223 patients (47%) died, 81 (17.2%) due to CV etiology. At multivariable analysis, older age (HR 1.06, 95%CI 1.02 to 1.11), LVEF < 35% (HR 2.97, 95%CI 1.24 to 7.15) and number of vessels treated during the index PCI (HR 1.75, 95%CI 1.12 to 2.72) were related to all-cause mortality, while only LVEF
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- 2021
17. Clinical Outcomes Following Isolated Transcatheter Tricuspid Valve Repair
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Alessandro Andreis, Filippo Angelini, Claudia Raineri, Pier Paolo Bocchino, Simone Frea, Stefano Pidello, Federico Fortuni, Luca Franchin, Gaetano M. De Ferrari, Alessandro Vairo, Antonio Montefusco, Gianluca Alunni, and Federico Conrotto
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medicine.medical_specialty ,Tricuspid valve ,medicine.anatomical_structure ,business.industry ,Meta-analysis ,Internal medicine ,medicine ,Cardiology ,Meta-regression ,TRICUSPID VALVE REPAIR ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives The aim of this study was to assess the pooled clinical and echocardiographic outcomes of different isolated transcatheter tricuspid valve repair (ITTVR) strategies for signific...
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- 2021
18. Predictors of fractional flow reserve/instantaneous wave-free ratio discordance: impact of tailored diagnostic cut-offs on clinical outcomes of deferred lesions
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Francesco Burzotta, Giorgio Quadri, Antonio Maria Leone, Federico Conrotto, Andrea Peirone, Guglielmo Gallone, Antonio Montefusco, Andrea Rognoni, Massimo Mancone, Jacopo Oreglia, Giuseppe Zaccardo, Enrico Cerrato, Ovidio De Filippo, Lucia Barbieri, Giampaolo Niccoli, Javier Escaned, Ferdinando Varbella, Gennaro Sardella, Irene Bossi, Gaetano M. De Ferrari, Pierluigi Omedè, Rocco A. Montone, Giacomo Boccuzzi, Carlo Trani, Fabrizio D'Ascenzo, Stefano Carugo, Chiara Castelli, and Mario Iannaccone
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Male ,business.industry ,Coronary Stenosis ,Coronary Artery Disease ,General Medicine ,Fractional flow reserve ,Prognosis ,Fractional Flow Reserve ,Time-to-Treatment ,Fractional Flow Reserve, Myocardial ,Control theory ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Myocardial Revascularization ,Humans ,Myocardial ,Medicine ,Female ,Instantaneous wave-free ratio ,Cardiology and Cardiovascular Medicine ,business ,Aged ,Retrospective Studies - Abstract
Patient-related and lesion-related factors may influence instantaneous wave-free ratio (iFR)/fractional flow reserve (FFR) concordance, potentially affecting the safety of revascularization deferral.Consecutive patients with at least an intermediate coronary stenosis evaluated by both iFR and FFR were retrospectively enrolled. The agreement between iFR and FFR at their diagnostic cut-offs (FFR 0.80, iFR 0.89) was assessed. Predictors of discordance were assessed using multivariate analyses. Tailored iFR cut-offs according to predictors of discordance best matching an FFR of 0.80 were identified. The impact of reclassification according to tailored iFR cut-offs on major cardiovascular events (MACE: cardiovascular death, myocardial infarction or target-lesion revascularization) among deferred lesions was investigated.Two hundred and ninety-nine intermediate coronary stenosis [FFR 0.84 (0.78-0.89), iFR 0.91 (0.87-0.95), 202 left main/left anterior descending (LM/LAD) vessels, 67.6%] of 260 patients were studied. Discordance rate was 23.4% (n = 70, 10.7% iFR-negative discordant, 12.7% iFR-positive discordant). Predictors of discordance were LM/LAD disease, multivessel disease, non-ST-elevation myocardial infarction, smoking, reduced eGFR and hypertension. Lesion reclassification with tailored iFR cut-offs based on patient-level predictors carried no prognostic value among deferred lesions. Reclassification according to lesion location, which was entirely driven by LM/LAD lesions (iFR cut-offs: 0.93 for LM/LAD, 0.89 for non-LM/LAD), identified increased MACE among lesions deferred based on a negative FFR, between patients with a positive as compared with a negative iFR (19.4 vs. 6.1%, P = 0.044), whereas the same association was not observed with the conventional 0.89 iFR cut-off (15 vs. 8.6%, P = 0.303).Tailored vessel-based iFR cut-offs carry prognostic value among FFR-negative lesions, suggesting that a one-size-fit-all iFR cut-off might be clinically unsatisfactory.
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- 2021
19. Benefit of Extended Dual Antiplatelet Therapy Duration in Acute Coronary Syndrome Patients Treated with Drug Eluting Stents for Coronary Bifurcation Lesions (from the BIFURCAT Registry)
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Young Bin Song, Jeehoon Kang, Carlo Di Mario, Javier Escaned, Imad Sheiban, Han-Mo Yang, Saverio Muscoli, Seung Ho Hur, Davide Capodanno, Bernardo Cortese, Hyo-Soo Kim, Soon-Jun Hong, Guglielmo Gallone, Joon-Hyung Doh, Federico Conrotto, Daniela Trabattoni, Radosław Parma, Gérard Helft, Chang-Wook Nam, Ovidio De Filippo, Leonardo De Luca, Hyeon-Cheol Gwon, Grzegorz Smolka, Antonio Montefusco, Giuseppe Patti, Kyung-Woo Park, Fabrizio D'Ascenzo, Seung Hwan Han, Woo Jung Chun, Jung-Kyu Han, Iacopo Colonnelli, Bon-Kwon Koo, Gaetano M. De Ferrari, Enrico Cerrato, Yoichi Imori, Andrea Saglietto, Ki Hong Choi, Veronica Dusi, Alessandra Truffa Giachet, Francesco Bruno, Mario Iannaccone, Università degli studi di Torino = University of Turin (UNITO), Seoul National University Hospital, University Hospital 'Maggiore della Carità' [Novara, Italy], Medical University of Silesia (SUM), Ospedale San Camillo-Forlanini, Samsung Medical Center Sungkyunkwan University School of Medicine, Institute Division of Hematology/Oncology, Ospedale San Giovanni Bosco [Turin, Italy] (OSGB), Keimyung University, Ospedale San Luigi Gonzaga, Gachon University Gil Medical Center [Incheon, Republic of Korea], Careggi University Hospital [Florence, Italie], Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Inje University, Ospedale di Asti [Asti, Italy] (OA), Korea University Anam Hospital [Seoul], Università degli Studi di Roma Tor Vergata [Roma], AOU Policlinico Vittorio-Emanuele [Catania, Italia], IRCCS Istituto Nazionale dei Tumori [Milano], Nippon Medical School [Tokyo, Japon], Università degli Studi di Pavia = University of Pavia (UNIPV), ASST Fatebenefratelli-Sacco [Milan, Italy], Clinica Pederzoli [Peschiera del Garda, Italy] (CP), and Lesnik, Philippe
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Male ,Acute coronary syndrome ,medicine.medical_specialty ,animal structures ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,Revascularization ,Drug Administration Schedule ,Percutaneous Coronary Intervention ,Internal medicine ,Clinical endpoint ,Humans ,Medicine ,Registries ,cardiovascular diseases ,Myocardial infarction ,Acute Coronary Syndrome ,Aged ,business.industry ,Dual Anti-Platelet Therapy ,Percutaneous coronary intervention ,Drug-Eluting Stents ,Middle Aged ,medicine.disease ,[SDV] Life Sciences [q-bio] ,Treatment Outcome ,Cohort ,Conventional PCI ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors ,Mace ,Follow-Up Studies - Abstract
Optimal dual antiplatelet therapy (DAPT) duration for patients undergoing percutaneous coronary intervention (PCI) for coronary bifurcations is an unmet issue. The BIFURCAT registry was obtained by merging two registries on coronary bifurcations. Three groups were compared in a two-by-two fashion: short-term DAPT (≤ 6 months), intermediate-term DAPT (6-12 months) and extended DAPT (>12 months). Major adverse cardiac events (MACE) (a composite of all-cause death, myocardial infarction (MI), target-lesion revascularization and stent thrombosis) were the primary endpoint. Single components of MACE were the secondary endpoints. Events were appraised according to the clinical presentation: chronic coronary syndrome (CCS) versus acute coronary syndrome (ACS). 5537 patients (3231 ACS, 2306 CCS) were included. After a median follow-up of 2.1 years (IQR 0.9-2.2), extended DAPT was associated with a lower incidence of MACE compared with intermediate-term DAPT (2.8% versus 3.4%, adjusted HR 0.23 [0.1-0.54], p
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- 2021
20. Evolution of tricuspid regurgitation after transcatheter edge-to-edge mitral valve repair for secondary mitral regurgitation and its impact on mortality
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Marianna Adamo, Matteo Pagnesi, Giulia Ghizzoni, Rodrigo Estévez‐Loureiro, Sergio Raposeiras‐Roubin, Daniela Tomasoni, Davide Stolfo, Gianfranco Sinagra, Antonio Popolo Rubbio, Francesco Bedogni, Federico De Marco, Cristina Giannini, Anna Sonia Petronio, Laura Stazzoni, Tomás Benito‐González, Felipe Fernández‐Vázquez, Carmen Garrote‐Coloma, Cosmo Godino, Eustachio Agricola, Andrea Munafò, Isaac Pascual, Pablo Avanzas, Victor Léon, Antonio Montefusco, Paolo Boretto, Stefano Pidello, Vanessa Moñivas‐Palomero, Maria Del Trigo, Elena Biagini, Alessandra Berardini, Francesco Saia, Luis Nombela‐Franco, Gabriela Tirado‐Conte, Alberto De Augustin, Berenice Caneiro‐Queija, Antonio De Luca, Luca Branca, Gregorio Zaccone, Laura Lupi, Erik Lipsic, Adriaan Voors, Marco Metra, Adamo, Marianna, Pagnesi, Matteo, Ghizzoni, Giulia, Estévez-Loureiro, Rodrigo, Raposeiras-Roubin, Sergio, Tomasoni, Daniela, Stolfo, Davide, Sinagra, Gianfranco, Popolo Rubbio, Antonio, Bedogni, Francesco, De Marco, Federico, Giannini, Cristina, Petronio, Anna Sonia, Stazzoni, Laura, Benito-González, Tomá, Fernández-Vázquez, Felipe, Garrote-Coloma, Carmen, Godino, Cosmo, Agricola, Eustachio, Munafò, Andrea, Pascual, Isaac, Avanzas, Pablo, Léon, Victor, Montefusco, Antonio, Boretto, Paolo, Pidello, Stefano, Moñivas-Palomero, Vanessa, Del Trigo, Maria, Biagini, Elena, Berardini, Alessandra, Saia, Francesco, Nombela-Franco, Lui, Tirado-Conte, Gabriela, De Augustin, Alberto, Caneiro-Queija, Berenice, De Luca, Antonio, Branca, Luca, Zaccone, Gregorio, Lupi, Laura, Lipsic, Erik, Voors, Adriaan, Metra, Marco, and Cardiovascular Centre (CVC)
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Mortality ,Transcatheter edge-to-edge mitral valve repair ,Tricuspid regurgitation ,Heart Failure ,OUTCOMES ,TRIVALVE ,Humans ,Mitral Valve ,Cardiology and Cardiovascular Medicine ,SYSTEM ,Retrospective Studies - Abstract
Aim: To evaluate short-term changes in tricuspid regurgitation (TR) after transcatheter edge-to-edge mitral valve repair (M-TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality. Methods and results: This is a retrospective analysis of SMR patients undergoing successful M-TEER (post-procedural mitral regurgitation ≤2+) at 13 European centres. Among 503 patients evaluated 79 (interquartile range [IQR] 40-152) days after M-TEER, 173 (35%) showed ≥1 degree of TR improvement, 97 (19%) had worsening of TR, and 233 (46%) remained unchanged. Smaller baseline left atrial diameter and residual mitral regurgitation 0/1+ were independent predictors of TR ≤2+ after M-TEER. There was a significant association between TR changes and New York Heart Association class and pulmonary artery systolic pressure decrease at echocardiographic re-assessment. At a median follow-up of 590 (IQR 209-1103) days from short-term echocardiographic re-assessment, all-cause mortality was lower in patients with improved compared to those with unchanged/worsened TR (29.6% vs. 42.3% at 3 years; log-rank p = 0.034). Baseline TR severity was not associated with mortality, whereas TR 0/1+ and 2+ at short-term follow-up was associated with lower all-cause mortality compared to TR 3/4+ (30.6% and 35.6% vs. 55.6% at 3 years; p < 0.001). A TR ≤2+ after M-TEER was independently associated with a 42% decreased risk of mortality (p = 0.011). Conclusion: More than one third of patients with SMR undergoing successful M-TEER experienced an improvement in TR. Pre-procedural TR was not associated with outcome, but a TR ≤2+ at short-term follow-up was independently associated with long-term mortality. Optimal M-TEER result and a small left atrium were associated with a higher likelihood of TR ≤2+ after M-TEER.
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- 2022
21. Another Brick in the Wall
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Fabrizio D'Ascenzo, Simone Frea, Stefano Pidello, Alessandro Vairo, Gaetano M. De Ferrari, Paolo Boretto, Vittoria Lodo, Vincenzo Cusenza, Fulvio Orzan, Gianluca Alunni, and Antonio Montefusco
- Subjects
Brick ,medicine.medical_specialty ,Percutaneous balloon valvuloplasty ,Stenosis ,business.industry ,Internal medicine ,medicine ,Cardiology ,Rheumatic mitral stenosis ,Limiting ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2021
22. Machine learning-based prediction of adverse events following an acute coronary syndrome (PRAISE): a modelling study of pooled datasets
- Author
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Iván J. Núñez-Gil, José Ramón González Juanatey, Marco G. Mennuni, Umberto Michelucci, Sergio Manzano-Fernández, Tim Kinnaird, Marco Aldinucci, Claudio Montalto, Giuseppe Patti, Pierluigi Omedè, Gianluca Mittone, Tetsuma Kawaji, Berenice Caneiro Queija, Lazar Velicki, Dario Piga, Alessandro Durante, Francesco Bruno, Stephen B. Wilton, Roberto Esposito, Andrés Íñiguez-Romo, Sergio Raposeiras-Roubín, Enrico Cerrato, Ovidio De Filippo, Iacopo Colonnelli, Masa-aki Kawashiri, Walter Grosso Marra, Andrea Saglietto, Guglielmo Gallone, Michela Sperti, Pier Paolo Bocchino, Gianluca Campo, Albert Ariza-Solé, Rafael Cobas-Paz, Angel Cequier, Antonio Montefusco, Federico Conrotto, Sergio Leonardi, Barbara Cantalupo, Andrea Rognoni, Alaide Chieffo, Marco Agostino Deriu, Francesco Piroli, Yasir Arfat, Fabrizio D'Ascenzo, Zenon Huczek, Alberto Dominguez-Rodriguez, Sebastiano Gili, Giorgio Quadri, Isabel Muñoz Pousa, María Cespón Fernández, Ferdinando Varbella, James M. Hughes, Mauro Pennone, Luigi Oltrona Visconti, José P.S. Henriques, Xiantao Song, Ioanna Xanthopoulou, Pedro Flores Blanco, Simone Biscaglia, Gaetano M. De Ferrari, Umberto Morbiducci, Giuseppe Biondi Zoccai, Shaoping Nie, Toshiharu Fujii, Emad Abu-Assi, Dimitrios Alexopoulos, Alberto Garay, Ángel López-Cuenca, Giacomo Boccuzzi, Christoph Liebetrau, Marta Malavolta, Mario Iannaccone, Cardiology, and ACS - Atherosclerosis & ischemic syndromes
- Subjects
Adult ,Male ,Acute coronary syndrome ,media_common.quotation_subject ,Clinical Decision-Making ,MEDLINE ,Datasets as Topic ,Socio-culturale ,Hemorrhage ,030204 cardiovascular system & hematology ,Machine learning ,computer.software_genre ,law.invention ,Machine Learning ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Randomized controlled trial ,law ,Humans ,Medicine ,acute coronary syndromes ,030212 general & internal medicine ,Myocardial infarction ,Acute Coronary Syndrome ,Mortality ,Praise ,Adverse effect ,cardiovascular disease ,machine learning ,myocardial infarction ,media_common ,Receiver operating characteristic ,business.industry ,General Medicine ,medicine.disease ,3. Good health ,Cohort ,Female ,Artificial intelligence ,business ,computer - Abstract
Summary Background The accuracy of current prediction tools for ischaemic and bleeding events after an acute coronary syndrome (ACS) remains insufficient for individualised patient management strategies. We developed a machine learning-based risk stratification model to predict all-cause death, recurrent acute myocardial infarction, and major bleeding after ACS. Methods Different machine learning models for the prediction of 1-year post-discharge all-cause death, myocardial infarction, and major bleeding (defined as Bleeding Academic Research Consortium type 3 or 5) were trained on a cohort of 19 826 adult patients with ACS (split into a training cohort [80%] and internal validation cohort [20%]) from the BleeMACS and RENAMI registries, which included patients across several continents. 25 clinical features routinely assessed at discharge were used to inform the models. The best-performing model for each study outcome (the PRAISE score) was tested in an external validation cohort of 3444 patients with ACS pooled from a randomised controlled trial and three prospective registries. Model performance was assessed according to a range of learning metrics including area under the receiver operating characteristic curve (AUC). Findings The PRAISE score showed an AUC of 0·82 (95% CI 0·78–0·85) in the internal validation cohort and 0·92 (0·90–0·93) in the external validation cohort for 1-year all-cause death; an AUC of 0·74 (0·70–0·78) in the internal validation cohort and 0·81 (0·76–0·85) in the external validation cohort for 1-year myocardial infarction; and an AUC of 0·70 (0·66–0·75) in the internal validation cohort and 0·86 (0·82–0·89) in the external validation cohort for 1-year major bleeding. Interpretation A machine learning-based approach for the identification of predictors of events after an ACS is feasible and effective. The PRAISE score showed accurate discriminative capabilities for the prediction of all-cause death, myocardial infarction, and major bleeding, and might be useful to guide clinical decision making. Funding None.
- Published
- 2021
23. A Score to Assess Mortality After Percutaneous Mitral Valve Repair
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Sergio Raposeiras-Roubin, Marianna Adamo, Xavier Freixa, Dabit Arzamendi, Tomas Benito-González, Antonio Montefusco, Isaac Pascual, Luis Nombela-Franco, Josep Rodes-Cabau, Mony Shuvy, Antonio Portolés-Hernández, Cosmo Godino, Berenice Caneiro-Queija, Laura Lupi, Ander Regueiro, Chin Hion Li, Felipe Fernández-Vázquez, Simone Frea, Pablo Avanzas, Gabriela Tirado-Conte, Jean-Michel Paradis, Alona Peretz, Vanessa Moñivas, Jose A. Baz, Michele Galasso, Luca Branca, Laura Sanchís, Lluís Asmarats, Carmen Garrote-Coloma, Filippo Angelini, Victor León, Eduardo Pozo, Alberto Alperi, Ronen Beeri, Dario Cani, Manel Sabaté, Estefanía Fernández-Peregrina, Javier Gualis, Pier Paolo Bocchino, Salvatore Curello, Emad Abu-Assi, Andrés Íñiguez-Romo, Francesco Bedogni, Antonio Popolo Rubbio, Luca Testa, Carmelo Grasso, and Rodrigo Estévez-Loureiro
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Heart Valve Prosthesis Implantation ,Male ,Cardiac Catheterization ,Time Factors ,transcatheter edge-to-edge mitral valve repair ,Mitral Valve Insufficiency ,Stroke Volume ,mortality ,Postoperative Complications ,Treatment Outcome ,score ,Aged ,Female ,Follow-Up Studies ,Humans ,Italy ,Mitral Valve ,Retrospective Studies ,Risk Factors ,Registries ,Cardiology and Cardiovascular Medicine - Abstract
BACKGROUND Risk stratification for transcatheter edge-to-edge mitral valve repair (TEER) is paramount in the decision-making process for treating severe mitral regurgitation (MR). OBJECTIVES This study sought to create and validate a user-friendly score (MitraScore) to predict the risk of mortality in patients undergoing TEER. METHODS The derivation cohort was based on a multicentric international registry that included 1,119 patients referred for TEER between 2012 and 2020. Score discrimination was assessed using Harrell's c-statistic, and the calibration was evaluated with the Gronnesby and Borgan goodness-of -fit test. An external validation was carried out in 725 patients from the GIOTTO registry. RESULTS After multivariate analysis, we identified 8 independent predictors of mortality during the follow-up (2.1 +/- 1.8 years): age $75 years, anemia, glomerular filtrate rate
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- 2022
24. Editoriale
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Andreose, Alvise, Eugenio, Burgio, Nadia, Cannata, Chiara, Concina, Elisa, Guadagnini, Antonio, Montefusco, and Maddalena, Signorini
- Subjects
Traduzione ,Traduzione, volgarizzamenti, storia della lingua, filologia romanza, latino medievale, filologia testuale ,latino medievale ,filologia testuale ,volgarizzamenti ,filologia romanza ,storia della lingua - Published
- 2022
25. Duration and kind of dual antiplatelet therapy for acute coronary syndrome patients: a network meta-analysis
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Fabrizio D'ASCENZO, Ovidio DE FILIPPO, Filippo ANGELINI, Francesco PIROLI, Giulia DE LIO, Pier Paolo BOCCHINO, Luca BALDETTI, Francesco MELILLO, Alaide CHIEFFO, Andrea SAGLIETTO, Pierluigi OMEDÈ, Antonio MONTEFUSCO, Federico CONROTTO, and Gaetano M. DE FERRARI
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Cardiology and Cardiovascular Medicine - Abstract
For acute coronary syndrome (ACS) patients treated with percutaneous coronary intervention (PCI), the choice of the duration and kind of dual antiplatelet therapy (DAPT) offering the most accurate balance between ischemic and bleeding risk remains unknown.A network meta-analysis was performed including all Randomized Controlled Trials (RCTs) comparing different DAPT regimens and duration in ACS patients undergoing PCI. Trial-defined MACE and major bleedings were the primary endpoints. Stroke, stent thrombosis (ST), all-cause and cardiovascular death, myocardial infarction (MI) represented secondary endpoints.13 RCTs encompassing 46145 patients were included. Mean age was 62 (61-64) years old, 42% being admitted with STEMI, 33% with NSTEMI and 25% with UA. The competitive arms were: clopidogrel and aspirin for 12 months (6 arms/18183 patients), clopidogrel and aspirin for 6 months (4/3329), clopidogrel and aspirin12 months (3/2238), ticagrelor and aspirin for 12 months (6/12942) and prasugrel and aspirin for 12 months (3/9453). Trial-defined MACE and major bleedings, stroke and death were similar among the different arms. DAPT with prasugrel and aspirin for 12 months reduced MI compared to aspirin and clopidogrel for 12 months (OR 0.71, 95%CI 0.54.0.94), and reduced the risk of ST compared to ticagrelor (OR 0.66, 95%CI 0.49-0.90). Both prasugrel and ticagrelor reduced ST as compared to clopidogrel and aspirin for 12 months.Different DAPT strategies yield similar risk of MACE, major bleeding, death and stroke in ACS patients. Prasugrel and aspirin for 12 months proved to be the most effective strategy regarding ST and MI.
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- 2022
26. 97 An unusual combination of rare congenital heart defects in a 70 years old lady complaining worsening dyspnea
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Matteo Bellettini, Antonio Montefusco, Andrea Angelini, Fulvio Orzan, Fabrizio D’Ascenzo, and Gaetano Maria De Ferrari
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Cardiology and Cardiovascular Medicine - Abstract
Methods and results A 70-year-old woman presented to our outpatient clinic complaining of worsening dyspnoea in the last 3 months. She had a medical history of hypertension, diabetes, dyslipidemia, and paroxysmal atrial fibrillation. We performed a comprehensive evaluation starting with a transthoracic echocardiogram that showed a dilatation of right ventricle with normal function, severe pulmonary regurgitation, and moderate tricuspid regurgitation with estimated pulmonary artery systolic pressure of 55 mmHg; the left ventricle had normal dimension and function, with mild aortic and mitral regurgitation, and a subaortic membrane which caused a mild obstruction (maximum gradient 17 mmHg). The cardiac magnetic resonance (CMR) confirmed the enlargement of the right ventricle and of the pulmonary artery trunk (51 mm) and the severity of pulmonary regurgitation (regurgitant fraction of 41%). CMR also clearly showed the VSD just below the subaortic membrane and the left to right shunt with a jet that appeared to proceed straight from the left ventricle through the pulmonary valve (Figure 1A). The estimated Qp/Qs was 1.6 and no intramyocardial late enhancement was present. Pulmonary pressures and pulmonary vascular resistance were normal at the right heart catheterization and the Qp/Qs ratio calculated invasively was 1.45. Considering patient high-risk profile for coronary artery disease, a coronary angiography was also performed showing an abnormal origin of the right coronary artery (RCA) from the mid-portion of the left anterior descending coronary artery (LAD) with two significant stenosis: one involving the bifurcation of RCA and the other the mid-portion of the LAD (Figure 1B). The coronary computed tomography angiography (CCTA) showed a benign course of the RCA anterior to the pulmonary artery towards the auriculoventricular groove (Figure 1C, D). Taking into account all these findings, multidisciplinary heart team decided to perform a cardiac surgery intervention of pulmonary valve and trunk replacement, closure of ventricular septal defect and two coronary bypass grafts on LAD and RCA. Conclusions This case represents a combination of some rare congenital heart abnormalities where multimodality cardiovascular imaging techniques were essential to establish a proper diagnosis and to plan an adequate surgical repair. We hypothesize that the peculiar orientation of the VSD jet may have caused the pulmonary trunk dilatation considering that neither the shunt, nor the pulmonary pressure appear to have been of sufficient magnitude to cause it. Pulmonary ectasia and the damage inflicted by the jet to the cusps of the valve have led to the severe valvular insufficiency. While aortic and tricuspid regurgitation are known to be associated with VSD, to the best of our knowledge this is the first report of pulmonary regurgitation secondary to VSD.
- Published
- 2021
27. Per l’edizione (digitale e non) dei Documenti d’Amore
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Antonio Montefusco
- Subjects
Settore L-FIL-LET/08 - Letteratura Latina Medievale e Umanistica ,Francesco da Barberino - Published
- 2021
28. Francesco da Barberino e i Documenti d’Amore: una premessa
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Sara Bischetti and Antonio Montefusco
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Settore L-FIL-LET/08 - Letteratura Latina Medievale e Umanistica ,Francesco da Barberino - Published
- 2021
29. Dante and Economics
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Enrico Fenzi, Kristina M. Olson, Antonio Montefusco, Maria Giuseppina Muzzarelli, Filippo Petricca, Giacomo Todeschini, William Caferro, Ronald L. Martinez, and Juan Varela-Portas De Orduña
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General Medicine - Published
- 2020
30. Echocardiographic estimation of right ventricular wall tension: haemodynamic comparison and long‐term follow‐up
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Walter Grosso Marra, Corrado Magnino, Gaetano M. De Ferrari, Pier Paolo Bocchino, Fabrizio D'Ascenzo, Umberto Annone, Alberto Milan, Pierluigi Omedè, Antonio Montefusco, and Franco Veglio
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Pulmonary and Respiratory Medicine ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Long term follow up ,echocardiography ,pulmonary hypertension ,right ventricle ,wall tension ,Hemodynamics ,Afterload ,Internal medicine ,medicine ,cardiovascular diseases ,lcsh:RC705-779 ,business.industry ,Tension (physics) ,Right ventricular infarction ,lcsh:Diseases of the respiratory system ,medicine.disease ,Pulmonary hypertension ,medicine.anatomical_structure ,lcsh:RC666-701 ,Ventricle ,cardiovascular system ,Cardiology ,business ,Research Article ,circulatory and respiratory physiology - Abstract
Prognosis in pulmonary hypertension is strictly linked to right ventricle failure, which results from uncoupling between right ventricle function and its afterload. This study sought to describe how to estimate with echocardiography right ventricular wall tension, its correlation with right ventricle haemodynamics and its prognostic role. A total of 190 patients without overt right ventricle failure but with suspected pulmonary hypertension on a previous echocardiogram underwent right heart catheterization and nearly-simultaneous echocardiography. Right ventricular wall tension was estimated according to Laplace’s law as right ventricle length × tricuspid regurgitation peak gradient and it was correlated with right ventricle haemodynamic profile; its potential prognostic impact was tested along with canonical right ventricle function parameters. Right ventricular wall tension correlated significantly with invasive estimation of right ventricle end-diastolic pressure (R: 0.343, p
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- 2019
31. Prognostic impact of MitraClip in patients with left ventricular dysfunction and functional mitral valve regurgitation: A comprehensive meta-analysis of RCTs and adjusted observational studies
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Carla Giustetto, Walter Grosso Marra, Maurizio D'Amico, Gabriele Crimi, Mauro Rinaldi, Fabrizio D'Ascenzo, Claudio Moretti, Federico Conrotto, Simone Frea, Leor Perl, Gianluca Alunni, Antonio Montefusco, Maurizio Bertaina, Gaetano M. De Ferrari, and Alessandro Galluzzo
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medicine.medical_specialty ,030204 cardiovascular system & hematology ,Patient Readmission ,law.invention ,Ventricular Dysfunction, Left ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,MitraClip ,030212 general & internal medicine ,Randomized Controlled Trials as Topic ,business.industry ,FMR ,Mitral Valve Insufficiency ,OMT ,HFrEF ,Odds ratio ,Prognosis ,Surgical Instruments ,medicine.disease ,Observational Studies as Topic ,Heart failure ,Meta-analysis ,Cardiology ,Observational study ,Cardiology and Cardiovascular Medicine ,Mitral valve regurgitation ,business ,Percutaneous Mitral Valve Repair - Abstract
The real prognostic impact of MitraClip in patients with significant functional mitral regurgitation (FMR) and left ventricular (LV) dysfunction remains to be elucidated. Two randomized controlled trials (RCTs) with conflicting results have been recently published. We conducted a comprehensive meta-analysis of all RCTs and adjusted observational studies to evaluate the clinical impact of percutaneous mitral valve repair when compared with optimal medical therapy (OMT) alone, in patients with symptomatic FMR and LV dysfunction. Death from any cause and heart failure rehospitalizations at the longest available follow-up were the primary endpoints. Cardiac death, one year and short-term death were the secondary ones. 2255 patients (1207 for MitraClip and 1048 for OMT-only) from 8 studies (2 RCTs and 6 observational studies) were included. At a median (mid-term) follow-up of 438 days (IQR 360-625) MitraClip was associated with a significant reduction of all-cause death (odds Ratio [OR] 0.55, 95%CI 0.41-0.73, p 0.001; [ORadj] 0.66, 95%CI 0.49-0.90, p = 0.009) and rehospitalization (OR 0.49, 95%CI 0.24-1.00, p = 0.05 and ORadj 0.63, 95%CI 0.43-0.94, p = 0.02). At one year, adjusted analysis demonstrated a trend favoring the experimental cohort (ORadj 0.73, 95%CI 0.53-1.02, p = 0.07). Meta-regression suggested that benefit of MitraClip on mid-term survival persists even after accounting for the prevalence of implanted CRT, burden of comorbidities, NYHA class, cardiomyopathy etiology and LV function and dimensions. In conclusion, MitraClip for FMR in patients with LV dysfunction is associated with a considerable reduction of death and HF hospitalization at mid-term follow-up. Further ongoing RCTs are needed to strengthen present results.
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- 2019
32. Prefazione
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Antonio Montefusco, Dávid Falvay, and Diego Dotto
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- 2021
33. Edizione delle didascalie e delle istruzioni
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Sara Bischetti, Péter Ertl, Dávid Falvay, Holly Flora, Eszter Konrád, Antonio Montefusco, and Ditta Szemere
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- 2021
34. Le Meditationes Vitae Christi in volgare secondo il codice Paris, BnF, it. 115 Edizione, commentario e riproduzione del corredo iconografico
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Diego Dotto, Dávid Falvay, and Antonio Montefusco
- Abstract
The Pseudo-Bonaventuran Meditationes vitae Christi is one of the most influential devotional narratives of the late middle ages. It was written in Tuscany in the early fourteenth century and survived in several Latin and vernacular manuscripts and early prints. An extensive discussion has engaged the scholars, especially about the issue of the first linguistic version of the text. Even if the Latin version seems to be the original text, the vernacular manuscript Paris, BnF, it. 115 stays as one of the most important and interesting witnesses of the work. One of the earliest surviving codices, it conserves the first Italian translation (penned in the Pisan area) of the text, enriched by a wonderful set of illustration. The present volume, which is the outcome of an international and interdisciplinary collaboration, offers the first critical edition of the text, the reproduction of all images, the edition of the instructions given to the artist, accompanied by detailed philological and art-historical commentaries, glossaries, and seven interdisciplinary introductory essays.
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- 2021
35. Corrigendum to ‘Long-Term (≥10 Years) Safety of Percutaneous Treatment of Unprotected Left Main Stenosis With Drug-Eluting Stents’[The American Journal of Cardiology 118 (2016) 32-39]
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Imad Sheiban, Claudio Moretti, Fabrizio D'Ascenzo, Alaide Chieffo, Salma Taha, Stephen O. Connor, SujaySubash Chandran, JM de la Torre Hernández, Sl Chen, Ferdinando Varbella, Pierluigi Omedè, Mario Iannaccone, Emanuele Meliga, Hiroyoshi Kawamoto, Antonio Montefusco, Mervyn Chong, Philippe Garot, Lin Sin, Valeria Gasparetto, Mohamed Abdirashid, Enrico Cerrato, Giuseppe Biondi Zoccai, Fiorenzo Gaita, Javier Escaned, David Hiddick Smith, Thierry Lefèvre, and Antonio Colombo
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Cardiology and Cardiovascular Medicine - Published
- 2022
36. Another Brick in the Wall: Percutaneous Balloon Valvuloplasty for Flow-Limiting Mitral Stenosis in a Patient With LVAD
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Paolo, Boretto, Alessandro, Vairo, Vincenzo, Cusenza, Gianluca, Alunni, Simone, Frea, Stefano, Pidello, Vittoria, Lodo, Fabrizio, D'Ascenzo, Fulvio, Orzan, Gaetano Maria, De Ferrari, and Antonio, Montefusco
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Balloon Valvuloplasty ,Treatment Outcome ,Rheumatic Heart Disease ,Humans ,Mitral Valve Stenosis ,Heart Valves - Published
- 2021
37. Clinical Outcomes Following Isolated Transcatheter Tricuspid Valve Repair: A Meta-Analysis and Meta-Regression Study
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Alessandro Vairo, Federico Conrotto, Gianluca Alunni, Alessandro Andreis, Simone Frea, Stefano Pidello, Federico Fortuni, Claudia Raineri, Luca Franchin, Antonio Montefusco, Filippo Angelini, G M De Ferrari, and Pier Paolo Bocchino
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transcatheter tricuspid valve repair ,medicine.medical_specialty ,Cardiac Catheterization ,transcatheter intervention ,Time Factors ,tricuspid valve ,Severity of Illness Index ,Internal medicine ,80 and over ,Medicine ,Humans ,Meta-regression ,TRICUSPID VALVE REPAIR ,tricuspid regurgitation ,Aged ,Aged, 80 and over ,Heart Valve Prosthesis Implantation ,business.industry ,TTVR ,Treatment Outcome ,Tricuspid Valve ,Tricuspid Valve Insufficiency ,Meta-analysis ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Significant tricuspid regurgitation (TR) is a common valvular heart disease worldwide. Purpose We aimed to assess the pooled clinical and echocardiographic outcomes of different isolated transcatheter tricuspid valve repair (ITTVR) strategies for significant (≥ moderate) TR. Methods We systematically searched the literature for studies evaluating the efficacy and safety of ITTVR for significant TR in adult. The primary outcomes were the improvement of New York Heart Association (NYHA) functional class and 6-minutes walking distance (6MWD) and the presence of severe or greater TR at the last available follow-up of each individual study. Random-effect meta-analysis was performed comparing outcomes before and after ITTVR. Results 14 studies with 771 patients were included. Mean age was 77±8 years and mean EuroScore II was 6.8%±5.4%. At a weighted mean follow-up of 212 days, 209 (35%) patients had a NYHA III to IV functional class compared to 586 (84%) patients at baseline (risk ratio: 0.23, 95% CI 0.13 to 0.40, P-value Conclusion Patients undergoing ITTVR for significant TR experienced a significant improvement in NYHA functional status and 6MWD and a significant reduction in TR severity at mid-term follow-up. Funding Acknowledgement Type of funding sources: None.
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- 2021
38. Premessa
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Sara Bischetti, Michele Lodone, Cristiano Lorenzi, and Antonio Montefusco
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Medieval Translation ,Medieval Italy ,Settore L-FIL-LET/09 - Filologia e Linguistica Romanza ,Settore L-FIL-LET/08 - Letteratura Latina Medievale e Umanistica - Published
- 2021
39. A mo’ d’introduzione Elementi di una storia sociale dell’attività del tradurre nella Toscana medievale (1260–1430)
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Antonio Montefusco
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Medieval Translation ,Medieval Italy ,Settore L-FIL-LET/09 - Filologia e Linguistica Romanza ,Settore L-FIL-LET/08 - Letteratura Latina Medievale e Umanistica - Published
- 2021
40. Roman de la Rose
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Antonio Montefusco
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Roman de la Rose, Jean de Meun, Guillaume de Lorris, Vita nova, Fiore, Detto D’Amore, Commedia, politics, poetry, knowledge ,knowledge ,Settore L-FIL-LET/09 - Filologia e Linguistica Romanza ,Vita nova ,Jean de Meun ,politics ,Guillaume de Lorris ,Fiore ,Detto D’Amore ,Roman de la Rose ,Commedia ,poetry - Abstract
This chapter intends to outline, in a succinct yet critical manner, the essential elements allowing us to establish a link between Guillaume de Lorris and Jean de Meun’s Roman de la Rose and the works of Dante, from the contested Fiore and Detto d’amore to the Commedia. Rather than seeking to provide an exhaustive picture, given the abundant critical literature available, this chapter addresses the following questions: 1) what is the Rose? 2) What did it represent to the generation of Tuscan poets from the second half of the 13th century, Cavalcanti and the young Dante, in particular? 3) What was its role in Dantean writing, especially in its complex poetics, politics, and organization of knowledge?
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- 2021
41. Disproportionate functional mitral regurgitation predicts a favourable response after MitraClip implant in patients with advanced heart failure. Real-world evidence of a new conceptual framework
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Mauro Rinaldi, Antonio Montefusco, Maurizio D'Amico, Francesca Giordana, Paolo Boretto, Sara Rettegno, Simone Frea, Stefano Pidello, Michele Torre, and Gaetano M. De Ferrari
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Heart failure ,030204 cardiovascular system & hematology ,Mitraclip ,Effective Regurgitant Orifice Area ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Ventricular remodeling ,Aged ,Heart transplantation ,Heart Valve Prosthesis Implantation ,Ejection fraction ,Functional mitral regurgitation ,Regurgitant fraction ,Ventricular Remodeling ,business.industry ,MitraClip ,Mitral Valve Insufficiency ,Middle Aged ,medicine.disease ,Treatment Outcome ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Mace - Abstract
Introduction Accurate predictors of good clinical response after MitraClip implant in patients with heart failure (HF) are still lacking. Aim of this study was to investigate the role of regurgitant fraction >50% as a marker of disproportionate functional mitral regurgitation (FMR) in identifying best responders to Mitraclip. Methods and results Data from 58 advanced HF patients (age 66 ± 8 years, 81% males, 63% NYHA class IV, LV ejection fraction (EF) 25.5 ± 5.5%) with disproportionate and proportionate FMR who underwent successful MitraClip implant were analyzed. After MitraClip all patient achieved mild (≤ 2+/4+) MR. During 12-month follow-up 18 patients (31%) had a major adverse cardiac event (MACE, i.e. cardiac death, urgent LVAD implant or heart transplantation, HF hospitalization). Disproportionate FMR (n = 48, 83%) was associated with a better clinical outcome (p = .003) while regurgitant volume and EROA were not. TAPSE ≤14 mm was associated with worse outcome (p = .018). At multivariable analysis only disproportionate MR and TAPSE ≤14 mm showed a significant association with MACE (p = .017 and p = .02, respectively). A reverse left ventricular remodeling (i.e., reduction on LV end-diastolic diameter and end-diastolic volume) was achieved only in the disproportionate FMR group. Conclusions In conclusion, disproportionate FMR assessed by regurgitant fraction and RV dysfunction assessed by TAPSE may help the selection of HF patients candidates for MitraClip therapy.
- Published
- 2021
42. Alla prova della storia (francescana): le MVC, testo senza autore
- Author
-
Antonio Montefusco
- Subjects
Settore L-FIL-LET/13 - Filologia della Letteratura Italiana ,Settore M-STO/01 - Storia Medievale ,Settore L-FIL-LET/08 - Letteratura Latina Medievale e Umanistica - Published
- 2021
43. Safety of FFR-guided revascularisation deferral in Anatomically prognostiC diseasE (FACE: CARDIOGROUP V STUDY): A prospective multicentre study
- Author
-
Massimo Mancone, Artur Dziewierz, Pierluigi Omedè, Rahim Kanji, Marcin Krakowian, Giuseppe Andò, Andrea Picchi, Alfonso Ielasi, Sergio Raposeiras-Roubín, Emmanuele Soraci, Simone Calcagno, Stefano Rigattieri, Claudio Moretti, Umberto Barbero, Miłosz Jaguszewski, Maurizio D'Amico, Víctor Alfonso Jiménez Díaz, Antonio Montefusco, Gianluca Campo, Francesco Gallo, Andrea Rognoni, Zenon Huczek, Roberto Verardi, Gennario Sardella, Mauro Rinaldi, Marco Francesco Lococo, Paweł Kleczyński, Mila Menozzi, Fabrizio D'Ascenzo, Enrico Cerrato, Javier Escaned, Massimo Fineschi, and Fiorenzo Gaita
- Subjects
Male ,medicine.medical_specialty ,left main ,medicine.medical_treatment ,Renal function ,Coronary Artery Disease ,Fractional flow reserve ,030204 cardiovascular system & hematology ,NO ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Angioplasty ,Internal medicine ,Myocardial Revascularization ,Clinical endpoint ,Humans ,Medicine ,Prospective Studies ,Registries ,030212 general & internal medicine ,Myocardial infarction ,angioplasty ,chronic kidney disease ,fractional flow reserve ,cardiology and cardiovascular medicine ,Aged ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Fractional Flow Reserve, Myocardial ,Survival Rate ,Concomitant ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Mace ,Follow-Up Studies - Abstract
FFR-guided coronary intervention is recommended for patients with intermediate stenoses. However, concerns exist with this approach in anatomically prognostic disease.In this prospective, multicentre study, we consecutively enrolled patients found to have FFR negative lesions in anatomically significant sites: left main; proximal LAD; last remaining patent vessel; and multiple vessels with concomitant impaired left ventricular systolic function (EF 40%). As per recommendation, revascularisation was deferred, and patients included into a registry. The primary endpoint was MACE (death, myocardial infarction and unplanned target lesion revascularization). Secondary endpoints were the above individual components. Subgroup analyses were performed for clinical presentation (stable vs. ACS), localization of lesion (ostial vs. non ostial) and renal function.The registry included 292 patients with 297 deferred stenoses. After 1-year, the primary endpoint occurred in 5% of patients, mainly driven by TLR (2.7%). Cardiovascular death occurred in 0.8% and AMI in 0.8%. During a follow-up of 22.2 ± 11 months, MACE occurred in 11.6%. Cardiovascular death occurred in 1.8% and AMI in 2.1%. After multivariate analysis, impaired renal function (OR 1.99; CI 95% 1.74-5.41; p = 0.046) and ostial disease (OR 2.88; CI 95% 1.04-7.38; p = 0.041) were found to be predictors of MACE. Impaired renal function also predicted TLR (OR 2.43; CI 95% 1.17-5.02; p = 0.017).FFR-guided revascularisation deferral is safe in the majority of anatomically prognostic disease. However, further evaluation is required in the risk stratification of those patients with ostial disease and renal disease. Registered on ClinicalTrials, NCT02590926.
- Published
- 2018
44. Percutaneous vs. surgical revascularization for patients with unprotected left main stenosis: a meta-analysis of 5 years follow-up RCTs
- Author
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Mario Gaudino, G.M De Ferrari, Fabrizio D'Ascenzo, O De Filippo, Edoardo Elia, Francesco Bruno, Luca Franchin, Mauro Pennone, Filippo Angelini, Antonio Montefusco, Stefano Salizzoni, Mauro Rinaldi, and M.P Doronzo
- Subjects
medicine.medical_specialty ,Percutaneous ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,Revascularization ,medicine.disease ,Surgery ,Coronary artery disease ,Coronary artery bypass surgery ,Stenosis ,Meta-analysis ,medicine ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business - Abstract
Introduction 5-year survival of patients with ULM (Unprotected Left Main) stenosis according to the choice of revascularization (percutaneous vs. surgical) remains to be defined. Methods and results Randomized Controlled Trials (RTCs) comparing Percutaneous Coronary Intervention (PCI) vs. Coronary Artery Bypass Graft (CABG) with a follow-up of at least 5 years were included. All-cause death was the primary endpoint. MACCE (a composite endpoint of all-cause mortality, myocardial infarction [MI], stroke and repeat revascularization) along with its single components and cardiovascular (CV) death were the secondary ones. Analyses were stratified according to use of first vs. last generation coronary stents. Subgroup comparisons were performed according to Syntax Score (below or above 33) and to age (using cutoffs of each trial's subgroup analysis). 4 RCTs with 4394 patients were identified: 2197 were treated with CABG, 657 with first generation and 1540 with last generation stents. At 5 years rates of all-cause death did not differ (OR 0.93: 0.71–1.21), as those of CV death and stroke. CABG reduced rates of MACCE (OR 0.69: 0.60–0.79), mainly driven by MI (OR 0.48: 0.36–0.65) and revascularization (OR 0.53: 0.45–0.64). Benefit of CABG for MACCE was consistent, although with different extent, across values of Syntax Score (OR 0.76: 0.59–0.97 for values Conclusion For patients with ULM disease, PCI and CABG yielded same survival benefit at 5 years. CABG reduced risk of MI, revascularization and MACCE especially in older patients and in those with diffuse coronary disease. Funding Acknowledgement Type of funding source: None
- Published
- 2020
45. «Ad consolationem legentium»
- Author
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Antonio Montefusco, Maria Conte, and Samuela Simion
- Subjects
Settore L-FIL-LET/09 - Filologia e Linguistica Romanza ,Marco Polo. Order of Preachers. Textual Studies. Dominican Reception. SS. Giovanni e Paolo. History of Venice. Marco Polo’s Medieval Audience. Medieval Translation ,Settore M-STO/01 - Storia Medievale ,Settore L-FIL-LET/08 - Letteratura Latina Medievale e Umanistica - Abstract
This book is the result of a fruitful exchange between the textual studies about Marco Polo’s Devisement dou Monde and the socio-historical research regarding Mendicant Orders. The Order of Preachers, in particular, includes the figure of the Venetian merchant as an auctoritas in the area of anthropological knowledge of Eastern traditions, through a Latin translation process contributing to evangelization in Asia. The aim of this book is to analyze the Dominican reception hybridizing philological and linguistical with historical and archival methods. The crossing of these research trajectories led to the finding of a parchment that testifies definitively the trusting relationship between Marco and the preachers of SS. Giovanni e Paolo convent. This convent is a key cultural center in the humanistic environment of Veneto, within which the Latin version Z is elaborated. This research has shed light on several fundamental moments of the P Latin version’s textual history, exploring the material aspects of manuscript witnesses as well as the textual relation with the vernacular source and Francesco Pipino’s Chronicon. Finally, an investigation is dedicated to the edifying adaptation of Marco Polo’s tales in Nicoluccio d’Ascoli’s sermons. The Dominican reception of Devisement dou Monde has relevant consequences for the text and its circulation, hopefully this book suggests a new perspective on Marco Polo and Dominican studies, stimulating further research.
- Published
- 2020
46. «Accipite hunc librum»
- Author
-
Antonio Montefusco
- Abstract
The contribution analyses the scattered but numerous indications of a contribution from the friars belonging to the convent of SS. Giovanni e Paolo in Venice at the first Latin diffusion of Marco Polo’s Devisement dou monde starting both from the possible attribution to this milieu of the Latin version Z, realised in the first thirty years of the fourteenth century, and from the presence of Marco in the document of 1323 which certifies the ratification of the legacy of Giovanni delle Boccole to the convent, and finally from the traces of literary activity of personalities in relationship with it, a network of preaching friars emerges in relationship with other nearby convents (in particular Treviso) and with the first two generations of Paduan humanists (in particular Albertino Mussato). These elements, if developed with wider investigations on the patrimony of the Venetian convent, can provide new insights for the interpretation of the Dominican appropriation of Marco’s text.
- Published
- 2020
47. A Politico-Communal Reading of theRose
- Author
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Antonio Montefusco
- Subjects
Rose (mathematics) ,Reading (process) ,media_common.quotation_subject ,Philosophy ,Religious studies ,media_common - Published
- 2020
48. Fractional flow reserve guided versus angiographic guided surgical revascularization: A meta-analysis
- Author
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Ovidio De Filippo, Giorgio Marengo, Federico Conrotto, Fabrizio D'Ascenzo, Luca Franchin, Francesco Piroli, Filippo Angelini, Gaetano M. De Ferrari, Guglielmo Gallone, Massimo Boffini, Antonio Montefusco, Andrea Saglietto, Francesco Bruno, Mauro Rinaldi, Marco Pocar, Mauro Pennone, Pierluigi Omedè, and Roberto Manfredi
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Fractional flow reserve ,Coronary Artery Disease ,Anastomosis ,Revascularization ,Coronary Angiography ,multiple vessel disease ,Percutaneous Coronary Intervention ,coronary artery bypass graft ,Internal medicine ,medicine.artery ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,Circumflex ,Coronary Artery Bypass ,fractional flow reserve ,Aged ,business.industry ,EuroSCORE ,General Medicine ,medicine.disease ,Fractional Flow Reserve, Myocardial ,Treatment Outcome ,Right coronary artery ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Mace ,Follow-Up Studies - Abstract
Background Clinical benefits of FFR (Fraction Flow Reserve) driven CABG (Coronary Artery Bypass Graft) remain to be established. Methods All randomized controlled trials (RCTs) and observational studies with multivariable adjustement were included. MACE (Major Adverse Cardiac Events) was the primary end point, while its single components (death, myocardial infarction, and total vessel revascularization [TVR]) along with number of anastomoses, on pump procedures and graft occlusion at angiographic follow-up were the secondary ones. Each analysis was stratified for RCTs versus observational studies. Results Four studies (two RCTs and two observational) were included, enrolling 983 patients, 542 angio-guided and 441 FFR-guided. Mean age was 68.45 years, 79% male, with a mean EuroSCORE I of 2.7. Coronary lesions were located in 37% of patients in the left anterior descending artery, 32% in the circumflex artery, and 26% in the right coronary artery. After a mean follow-up of 40 months, risk of MACE did not differ (OR 0.86 [0.63-1.18]) as that of all cause death (OR 0.86 [0.59-1.25]), MI (OR 0.57 [0.30-1.11]) and TVR (OR 1.10 [0.65-1.85]). FFR-driven CABG reduced on-pump procedures (OR 0.58 [0.35-0.93]) and number of anastomoses (-0.40 [-0.80: -0.01]) while incidence of graft occlusion at follow-up did not differ (OR 0.59 [0.30-1.15], all CI 95%). Conclusion Fraction flow reserve driven CABG reduced the number of anastomoses and of on-pump procedures without increasing risk of MACE and without reducing graft occlusion at angiographic follow-up. ID CRD42020211945.
- Published
- 2020
49. Stimuli, Remedia e altre immagini : sulla rivoluzione devozionale dei francescani
- Author
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Antonio Montefusco
- Subjects
Francescani ,Pietro di Giovanni Olivi ,Giovanni da Parma ,Bonaventura ,Stimulus Amoris ,Meditationes Vitae Christi - Abstract
Il contributo propone una interpretazione di un gruppo di testi circolanti in latino e volgare a cavallo tra XIII e XIV secolo, in particolare lo Stimulus Amoris, le Meditationes Vitae Christi e altri testi devozionali di area francescana. Solitamente accorpati al corpus bonaventuriano, questi testi presentano delle peculiarità proprie, che si possono riassumere nella instabilità "d’autore", nella interpictoriality e nel rapporto complesso tra le diverse versioni linguistiche. Questa testualità, che diventerà centrale nella scrittura religiosa successiva, è forse da far risalire all’iniziativa di Giovanni da Parma. The contribution proposes an interpretation of a group of texts circulating in Latin and the vernacular at the turn of the thirteenth and fourteenth centuries, in particular the Stimulus Amoris, the Meditationes Vitae Christi and other devotional texts of the Franciscan area. Usually merged with the Bonaventurian corpus, these texts have their own peculiarities, which can be summarized in the "author's instability", in the interpictoriality and in the complex relationship between the different language versions. This textuality, which will become central to subsequent religious writing, is perhaps to be traced back to the initiative of Giovanni da Parma.
- Published
- 2020
50. Le epistole attraverso i contesti
- Author
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Antonio Montefusco and Giuliano Milani
- Published
- 2020
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