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1. Differential response to preoperative exercise training in patients candidates to cardiac valve replacement

Author

Antonio López-Hernández, Elena Gimeno-Santos, Ricard Navarro-Ripoll, María José Arguis, Bárbara Romano-Andrioni, Manuel López-Baamonde, Silvia Teres, María Sanz-de la Garza, and Graciela Martinez-Palli

Subjects
Exercise training, Multimodal prehabilitation, Cardiac surgery, Complications, Functional capacity, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background There is lack of evidence regarding safety, effectiveness and applicability of prehabilitation on cardiac surgery population, particularly in patients candidates to cardiac valve replacement. The aim of the study is to assess and compare the effect of a multimodal prehabilitation program on functional capacity in patients with severe aortic stenosis (AoS) and severe mitral regurgitation (MR) proposed for valve replacement surgery. Methods Secondary analysis from a randomised controlled trial whose main objective was to analyze the efficacy of a 4–6 weeks multimodal prehabilitation program in cardiac surgery on reducing postoperative complications. For this secondary analysis, only candidates for valve replacement surgery were selected. The primary outcome was the change in endurance time (ET) from baseline to preoperative assessment measured by a cycling constant work-rate cardiopulmonary exercise test. Results 68 patients were included in this secondary analysis, 34 (20 AoS and 14 MR) were allocated to the prehabilitation group and 34 (20 AoS and 14 MR) to control group. At baseline, patients with AoS had better left systolic ventricular function and lower prevalence of atrial fibrillation compared to MR (p = 0.022 and p = 0.035 respectively). After prehabilitation program, patients with MR showed greater improvement in ET than AoS patients (101% vs. 66% increase from baseline). No adverse events related to the prehabilitation program were observed. Conclusions A 4–6 week exercise training program is safe and overall improves functional capacity in patients with severe AoS and MR. However, exercise response is different according to the cardiac valve type disfunction, and further studies are needed to know the factors that predispose some patients to have better training response. Trial registration The study has been registered on the Registry of National Institutes of Health ClinicalTrials.gov (NCT03466606) (05/03/2018).

Published
2024
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2. Repercusiones de la auditoría de costes y precios en los sistemas de información para la gestión empresarial: el caso de Indra Sistemas

Author

José Aguado Romero, Antonio López Hernández, and Simón Vera Ríos

Subjects
Political science (General), JA1-92, Social sciences (General), H1-99
Abstract

La sujeción de los suministradores de bienes y servicios a la normativa impuesta por los departamentos de defensa en materia de auditoría de contratos motiva que las empresas hayan desarrollado procedimientos específicos para la elaboración de las ofertas y para el suministro de información sobre costes y precios referentes a la ejecución del contrato. En el marco de la teoría institucional, el objetivo de este trabajo es analizar la incidencia que los procesos de auditorías de costes y precios tienen en los sistemas de información para la gestión y las repercusiones económicas en las empresas del sector de la defensa auditadas. El trabajo realizado es de naturaleza cualitativa y se ha empleado el estudio de caso como estrategia de investigación. Los principales hallazgos muestran que la aplicación de la auditoría de costes y precios por los Departamentos de Defensa ha originado cambios y adaptaciones en los sistemas de información para la gestión de las empresas de la industria de la defensa y en particular, en sus sistemas de cálculo de costes.

Published
2013

3. The Bologna process and the Higher Education reform: Has there been greater incorporation of Corporate Social Responsibility in business education in Spain?

Author

Manuel Larrán Jorge, Antonio López Hernández, and Francisco Javier Andrades Peña

Subjects
competencias profesionales, objetivos educacionales, responsabilidad social, enseñanza universitaria, espacio europeo de educación superior, planes de estudios universitarios, Education
Abstract

The current crisis, unsustainable growth, financial scandals involves reflection on the role of universities in the professional training, particularly those who have to manage businesses. On this issue, there is a perception that the teaching of ethics and corporate social responsibility (CSR) is insufficient (Baetz and Sharp, 2004; Kashyap et al., 2006). In this regard, universities play a fundamental role due both to the impact of the incorporation of CSR into the design of their study and research programs, and its incorporation into universities’ mission, vision, and corporate strategy (Muijen, 2004). Then, the present study focuses jon analyzing both the definition of educational objectives and skills development to be acquired by students as the level of inclusion of CSR offered by Spanish universities. In particular, the present paper focuses on analyzing reports verified by National Agency for Quality Assessment of degrees related to the organizational management area implemented in the 2010-2011 academic course, which degrees has been developed based on European Higher Education Area. Based on previous papers, the results of the present paper show that the Bologna process and the Higher Education reform in Spanish universities have promoted an increase of the presence of CSR in the business education.

Published
2012
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4. El Proceso de Bolonia: ¿Ha propiciado una mayor incorporación de la responsabilidad social en los grados relacionados con la economía y la empresa?

Author

Manuel Larrán Jorge, Antonio López Hernández, and Francisco Javier Andrades Peña

Subjects
Competencias profesionales, Objetivos educacionales, Responsabilidad social, Enseñanza universitaria, Espacio Europeo de Educación Superior, Planes de estudios universitarios, Education
Abstract

La crisis actual, el crecimiento insostenible, los escándalos financieros, exigen una reflexión sobre el papel de las universidades en la formación de profesionales, particularmente de aquéllos que tienen que administrar y gestionar empresas. En este sentido, existe una percepción de que la formación en valores éticos y en una conducta socialmente responsable de estos profesionales es insuficiente (Baetz y Sharp, 2004; Kashyap et al., 2006). Es por ello que el presente trabajo se encarga de analizar, tanto la definición de objetivos y competencias a adquirir por los estudiantes, como la oferta formativa de las universidades españolas en materia de responsabilidad social (RSC). Para ello se tomará como referencia las memorias verificadas positivamente por la Agencia Nacional de Evaluación y Acreditación de la Calidad (ANECA) de los títulos más cercanos al ámbito de la gestión de organizaciones ofertados por las universidades españolas en el curso 2010/2011, momento en el cual comienza a impartirse los nuevos grados adaptados al Proceso de Bolonia, con la finalidad de comparar los resultados obtenidos con la literatura. Sobre este particular, el presente estudio muestra que la adaptación de la oferta formativa universitaria al Espacio Europeo de Educación Superior ha supuesto una mayor presencia de la RSC en los estudios universitarios. ABSTRACTThe Bologna process and the Higher Education reform: Has there been greater incorporation of Corporate Social Responsibility in business education in Spain?The current crisis, unsustainable growth, financial scandals involves reflection on the role of universities in the professional training, particularly those who have to manage businesses. On this issue, there is a perception that the teaching of ethics and corporate social responsibility (CSR) is insufficient (Baetz and Sharp, 2004; Kashyap et al., 2006). In this regard, universities play a fundamental role due both to the impact of the incorporation of CSR into the design of their study and research programs, and its incorporation into universities’ mission, vision, and corporate strategy (Muijen, 2004). Then, the present study focuses jon analyzing both the definition of educational objectives and skills development to be acquired by students as the level of inclusion of CSR offered by Spanish universities. In particular, the present paper focuses on analyzing reports verified by National Agency for Quality Assessment of degrees related to the organizational management area implemented in the 2010-2011 academic course, which degrees has been developed based on European Higher Education Area. Based on previous papers, the results of the present paper show that the Bologna process and the Higher Education reform in Spanish universities have promoted an increase of the presence of CSR in the business education.

Published
2012

5. Epidemiología de la mortalidad por cáncer. Puerto Padre, 2011

Author

Zoraida Vivar Rivas and Antonio López Hernández

Subjects
neoplasias/epidemiología, neoplasias/mortalidad., Medicine, Medicine (General), R5-920
Abstract

Se realizó un estudio descriptivo retrospectivo y transversal de la base de datos de fallecidos por cáncer en el año 2011 en el municipio de Puerto Padre. El estudio estuvo constituido por los 178 fallecidos en el municipio. Se utilizaron variables tanto cualitativas como cuantitativas, distribuyéndose por grupos de edades, raza y sexo, se precisaron las principales localizaciones del cáncer por áreas de salud, estratificándose por consejos populares con el sistema de estratificación geográfica MAPINFO y se determinaron los años de vida potencialmente perdidos por esta patología. Como resultado, se obtuvo que los grupos de edades más afectados fueron los de 75 y más años, seguido del grupo de 65 a 69 años; el sexo de mayor mortalidad resultó el masculino, así como la raza blanca, con el 92.6% de los decesos. Además, se ha concluido que los consejos populares (C.P) más afectados según tasa fueron el 14 y el 15 del área urbana del “Romárico Oro”, significando que el único C.P sin fallecidos fue el cuatro, Pozo Prieto, del área rural del Policlínico “28 de Septiembre”. Se perdieron 14,2 años de vida por cada fallecido por cáncer en el 2011.

Published
2015

6. Multimodal Prehabilitation in Heart Transplant Recipients Improves Short-Term Post-Transplant Outcomes without Increasing Costs

Author

Manuel López-Baamonde, María José Arguis, Ricard Navarro-Ripoll, Elena Gimeno-Santos, Bárbara Romano-Andrioni, Marina Sisó, Silvia Terès-Bellès, Antonio López-Hernández, Adrià Burniol-García, Marta Farrero, Raquel Sebio-García, Elena Sandoval, María Sanz-de la Garza, Julián Librero, Ana García-Álvarez, María Ángeles Castel, and Graciela Martínez-Pallí

Subjects
heart transplantation, prehabilitation, preoperative optimization, aerobic capacity, postoperative complications, cost-analysis, Medicine
Abstract

(1) Background and aim: This study aimed to investigate the impact of prehabilitation on the postoperative outcomes of heart transplantation and its cost-effectiveness. (2) Methods: This single-center, ambispective cohort study included forty-six candidates for elective heart transplantation from 2017 to 2021 attending a multimodal prehabilitation program consisting of supervised exercise training, physical activity promotion, nutritional optimization, and psychological support. The postoperative course was compared to a control cohort consisting of patients transplanted from 2014 to 2017 and those contemporaneously not involved in prehabilitation. (3) Results: A significant improvement was observed in preoperative functional capacity (endurance time 281 vs. 728 s, p < 0.001) and quality-of-life (Minnesota score 58 vs. 47, p = 0.046) after the program. No exercise-related events were registered. The prehabilitation cohort showed a lower rate and severity of postoperative complications (comprehensive complication index 37 vs. 31, p = 0.033), lower mechanical ventilation time (37 vs. 20 h, p = 0.032), ICU stay (7 vs. 5 days, p = 0.01), total hospitalization stay (23 vs. 18 days, p = 0.008) and less need for transfer to nursing/rehabilitation facilities after hospital discharge (31% vs. 3%, p = 0.009). A cost-consequence analysis showed that prehabilitation did not increase the total surgical process costs. (4) Conclusions: Multimodal prehabilitation before heart transplantation has benefits on short-term postoperative outcomes potentially attributable to enhancement of physical status, without cost-increasing.

Published
2023
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9. <scp>3‐Methylcyclohex</scp> ‐2‐en‐1‐one reduces the aggregation of Dendroctonus pseudotsugae barragani and corresponding mortality of Pseudotsuga menziesii in northern Mexico

Author

Guillermo Sánchez‐Martínez, Constance J. Mehmel, Ernesto González‐Gaona, Sylvia R. Mori, Juan Antonio López‐Hernández, José Carlos Monárrez‐González, José Leonardo García‐Rodríguez, Jorge Manuel Mejía‐Bojórquez, and Nancy E. Gillette

Subjects
Insect Science, Forestry, Agronomy and Crop Science
Published
2022

10. Analgesia after Labor and Cesarean Section: Chronic Pain after Pregnancy

Author

Carmen Gomar Sancho, Ana Plaza Moral, Marina Vendrell Jordà, Antonio López Hernández, and Irene León Carsí

Abstract

Chronic pain (CP) conditions after childbirth include persistent pain after caesarean section (CPCS), perineal pain after instrumental vaginal delivery, lower back pain and pelvic girdle pain. Any type of CP before or during pregnancy increases the risk of CP after delivery. Scar pain is the most recognized etiology for CPCS with a neuropathic component, although it is less frequent than in other surgeries. Reported CPCS incidence ranges from 1 to 23%. Pain intensity is moderate and decreases with time in all studies. The severity and duration of peripartum pain are the main risk factors for CP and its control is the most recommended strategy for reducing risk. Fear of fetal and neonatal adverse events means that CP is often undertreated, but after delivery, pharmacological restrictions disappear and many pain drugs are compatible with breastfeeding. Education of obstetric teams about early detection and referral to specialized consultation of women with CP is the key. In this chapter, available information in the recent literature, mainly during the last years, is presented. This chapter focuses on CP conditions after childbirth, as analgesia for labor and childbirth and immediate pain after CS and vaginal delivery are covered in other chapters of this book.

Published
2022

11. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Niklas S. Campos, Thomas Bluth, Sabrine N.T. Hemmes, Julian Librero, Natividad Pozo, Carlos Ferrando, Lorenzo Ball, Guido Mazzinari, Paolo Pelosi, Marcelo Gama de Abreu, Marcus J. Schultz, A. Serpa Neto, Sabrine NT. Hemmes, Paolo Severgnini, Markus W. Hollmann, Jan M. Binnekade, Hermann Wrigge, Jaume Canet, Michael Hiesmayr, Werner Schmid, Edda Tschernko, Samir Jaber, Göran Hedenstierna, Christian Putensen, Agnes Marti, Alessandro Bacuzzi, Alexander Brodhun, Alexandre Molin, Alfred Merten, Ana Parera, Andrea Brunelli, Andrea Cortegiani, Andreas Güldner, Andreas W. Reske, Angelo Gratarola, Antonino Giarratano, Bea Bastin, Bjorn Heyse, Branka Mazul-Sunko, Bruno Amantea, Bruno Barberis, Christopher Uhlig, Conrado Minguez Marín, Cristian Celentano, Daniela La Bella, David D’Antini, David Velghe, Demet Sulemanji, Edoardo De Robertis, Eric Hartmann, Francesca Montalto, Francesco Tropea, Gary H. Mills, Gilda Cinnella, Giorgio Della Rocca, Girolamo Caggianelli, Giulia Pellerano, Giuseppina Mollica, Guillermo Bugedo, Jan-Paul Mulier, Jeroen Vandenbrande, Johann Geib, Jonathan Yaqub, Jorge Florez, Juan F. Mayoral, Juraj Sprung, Jurgen Van Limmen, Lieuwe DJ. Bos, Luc de Baerdemaeker, Luc Jamaer, Luigi Spagnolo, Lydia Strys, Manuel Granell Gil, Marcos F. Vidal Melo, Maria Carmen Unzueta, Maria Victoria Moral, Marion Ferner, Martin Weiss, Massimo Vanoni, Maximilian S. Schaefer, Mercè Prieto, Michele Grio, Peter Markus Spieth, Philipp Simon, Phoebe Bodger, Pilar Sierra, Rita Laufenberg-Feldmann, Roberta Rusca, Rodolfo Proietti, Santi Maurizio Raineri, Santo Caroleo, Sergi Sabaté, Stefan De Hert, Stefano Pezzato, Tanja A. Treschan, Tatjana Goranovic, Thea Koch, Thomas Kiss, Valter Perilli, Virginia Cegarra, Javier Belda, Marina Soro, Carmen Unzueta, Fernando Suarez-Sipmann, Julián Librero, Alicia Llombart, Lucas Rovira, Manuel Granell, César Aldecoa, Oscar Diaz-Cambronero, Jaume Balust, Ignacio Garutti, Rafael Gonzalez, Lucia Gallego, Santiago Garcia del Valle, Javier Redondo, David Pestaña, Aurelio Rodríguez, Javier García, Manuel de la Matta, Maite Ibáñez, Francisco Barrios, Samuel Hernández, Vicente Torres, Salvador Peiró, Abigail Villena, Albert Carramiñana, Alberto Gallego-Casilda, Alejandro Duca, Amalia Alcón, Amanda Miñana, Ana Asensio, Ana Colás, Ana Isabel Galve, Ana Izquierdo, Ana Jurado, Ana María Pérez, Ana Mugarra, Andrea Gutierrez, Ángeles De Miguel, Angels Lozano, Antonio Katime, Antonio Romero, Beatriz Garrigues, Begoña Ayas, Blanca Arocas, Carlos Delgado, Carmen Fernández, Carolina Romero, Clara Gallego, Cristina Garcés, Cristina Lisbona, Cristina Parrilla, Daniel López-Herrera, Domingo González, Eduardo Llamazares, Elena Del Rio, Elena Lozano, Ernesto Pastor, Estefanía Chamorro, Estefanía Gracia, Ester Sánchez, Esther Romero, Fernando Díez, Ferran Serralta, Francisco Daviu, Francisco Sandín, Gerardo Aguilar, Gerardo Tusman, Gonzalo Azparren, Graciela Martínez-Pallí, Inmaculada Benítez, Inmaculada Hernandéz, Inmaculada India, Irene León, Isabel Fuentes, Isabel Ruiz, Jaume Puig, Javie Ignacio Román, Jesús Acosta, Jesús Rico-Feijoo, Jonathan Olmedo, Jose A. Carbonell, Jose M. Alonso, Jose María Pérez, Jose Miguel Marcos, Jose Navarro, Jose Valdivia, Juan Carrizo, Laura Piqueras, Laura Soriano, Laura Vaquero, Lisset Miguel, Lorena Muñoz, Lucia Valencia, Luis Olmedilla, Mᵃ Justina Etulain, Manuel Tisner, María Barrio, María Dolores Alonso, María García, María J. Hernández, María José Alberola, María Parra, María Pilar Argente, María Vila, Mario De Fez, Marta Agilaga, Marta Gine, Mercedes Ayuso, Mercedes García, Natalia Bejarano, Natalia Peña, Nazario Ojeda, Nilda Martínez, Nuria García, Oto Padrón, Pablo García, Paola Valls, Patricia Cruz, Patricia Piñeiro, Pedro Charco, Rafael Anaya, Ramiro López, Rayco Rodríguez, Rocío Martínez, Roger Pujol, Rosa Dosdá, Rosa Lardies, Ruben Díaz, Rubén Villazala, Sara Zapatero, Sergio Cabrera, Sergio Sánchez, Silvia Martin, Suzana Diaz, Tania Franco, Tania Moreno, Tania Socorro, Vicente Gilabert, Victor Balandrón, Victoria Moral, Virgina Cegarra, Viviana Varón, Fernando Abelha, Sühayla Abitağaoğlu, Marc Achilles, Afeez Adebesin, Ine Adriaensens, Charles Ahene, Fatima Akbar, Mohammed Al Harbi, Rita Al Khoury al Kallab, Xavier Albanel, Florence Aldenkortt, Rawan Abdullah Saleh Alfouzan, Reef Alruqaie, Fernando Altermatt, Bruno Luís de Castro Araujo, Genaro Arbesú, Hanna Artsi, Caterina Aurilio, Omer Hilmi Ayanoglu, Harris Baig, Yolanda Baird, Konstantin Balonov, Samantha Banks, Xiaodong Bao, Mélanie Baumgartner, Isabel Belda Tortosa, Alice Bergamaschi, Lars Bergmann, Luca Bigatello, Elena Biosca Pérez, Katja Birr, Elird Bojaxhi, Chiara Bonenti, Iwona Bonney, Elke M.E. Bos, Sara Bowman, Leandro Gobbo Braz, Elisa Brugnoni, Sorin J. Brull, Iole Brunetti, Andrea Bruni, Shonie L. Buenvenida, Cornelius Johannes Busch, Giovanni Camerini, Beatrice Capatti, Javiera Carmona, Jaime Carungcong, Marta Carvalho, Anat Cattan, Carla Cavaleiro, Davide Chiumello, Stefano Ciardo, Mark Coburn, Umberto Colella, Victor Contreras, Pelin Corman Dincer, Elizabeth Cotter, Marcia Crovetto, William Darrah, Simon Davies, Enrique Del Cojo Peces, Ellise Delphin, John Diaper, Paulo do Nascimento Junior, Valerio Donatiello, Jing Dong, Maria do Socorro Dourado, Alexander Dullenkopf, Felix Ebner, Hamed Elgendy, Christoph Ellenberger, Dilek Erdoğan Arı, Thomas Ermert, Fadi Farah, Ana Fernandez-Bustamante, Cristina Ferreira, Marco Fiore, Ana Fonte, Christina Fortià Palahí, Andrea Galimberti, Najia Garofano, Luca Gregorio Giaccari, Fernando Gilsanz, Felix Girrbach, Luca Gobbi, Marc Bernard Godfried, Nicolai Goettel, Peter A. Goldstein, Or Goren, Andrew Gorlin, Juan Graterol, Pierre Guyon, Kevin Haire, Philippe Harou, Antonia Helf, Gunther Hempel, María José Hernández Cádiz, Björn Heyse, Ivan Huercio, Jasmina Ilievska, Lien Jakus, Vijay Jeganath, Yvonne Jelting, Minoa Jung, Barbara Kabon, Aalok Kacha, Maja Karaman Ilić, Arunthevaraja Karuppiah, Ayse Duygu Kavas, Gleicy Keli Barcelos, Todd A. Kellogg, Johann Kemper, Romain Kerbrat, Suraya Khodr, Peter Kienbaum, Bunyamin Kir, Selin Kivrak, Vlasta Klarić, Ceren Köksal, Ana Kowark, Peter Kranke, Bahar Kuvaki, Biljana Kuzmanovska, John Laffey, Mirko Lange, Marília Freitas de Lemos, Marc-Joseph Licker, Manuel López-Baamonde, Antonio López-Hernández, Mercedes Lopez-Martinez, Stéphane Luise, Mark MacGregor, Danielle Magalhães, Julien Maillard, Patrizia Malerbi, Natesan Manimekalai, Michael Margarson, Klaus Markstaller, Archer K. Martin, David P. Martin, Yvette N. Martin, Julia Martínez-Ocon, Ignacio Martin-Loeches, Emilio Maseda, Idit Matot, Niamh McAuliffe, Travis J. McKenzie, Paulina Medina, Melanie Meersch, Angelika Menzen, Els Mertens, Bernd Meurer, Tanja Meyer-Treschan, Changhong Miao, Camilla Micalizzi, Morena Milić, Norma Sueli Pinheiro Módolo, Pierre Moine, Patrick Mölders, Ana Montero-Feijoo, Enrique Moret, Markus K. Muller, Zoe Murphy, Pramod Nalwaya, Filip Naumovski, Paolo Navalesi, Lais Helena Navarro e Lima, Višnja Nesek Adam, Claudia Neumann, Christopher Newell, Zoulfira Nisnevitch, Junaid Nizamuddin, Cecilia Novazzi, Michael O'Connor, Günther Oprea, Mukadder Orhan Sungur, Şule Özbilgin, Maria Caterina Pace, Marcos Pacheco, Balaji Packianathaswamy, Estefania Palma Gonzalez, Fotios Papaspyros, Sebastián Paredes, Maria Beatrice Passavanti, Juan Cristobal Pedemonte, Sanja Peremin, Christoph Philipsenburg, Daniela Pinho, Silvia Pinho, Linda M. Posthuma, Vincenzo Pota, Benedikt Preckel, Paolo Priani, Mohamed Aymen Rached, Aleksandar Radoeshki, Riccardo Ragazzi, Tamilselvan Rajamanickam, Arthi Rajamohan, Harish Ramakrishna, Desikan Rangarajan, Christian Reiterer, J. Ross Renew, Thomas Reynaud, Rhidian Rhys, Eva Rivas, Luisa Robitzky, Rolf Rossaint, Francesca Rubulotta, Humberto S. Machado, Catarina S. Nunes, Giovanni Sabbatini, Jon D. Samuels, Josep Martí Sanahuja, Pasquale Sansone, Alice Santos, Mohamed Sayedalahl, Martin Scharffenberg, Eduardo Schiffer, Nadja Schliewe, Raoul Schorer, Roman Schumann, Gabriele Selmo, Mar Sendra, Mert Senturk, Kate Shaw, Mirjana Shosholcheva, Abdulrazak Sibai, Francesca Simonassi, Claudia Sinno, Nukhet Sivrikoz, Vasiliki Skandalou, Neil Smith, Maria Soares, Tania Socorro Artiles, Diogo Sousa Castro, Miguel Sousa, Savino Spadaro, Emmanouil Stamatakis, Luzius A. Steiner, Andrea Stevenazzi, Alejandro Suarez-de-la-Rica, Mélanie Suppan, Robert Teichmann, José Maria Tena Guerrero, Bram Thiel, Raquel Tolós, Gulbin Tore Altun, Michelle Tucci, Zachary A. Turnbull, Žana Turudić, Matthias Unterberg, Yves Van Nieuwenhove, Julia Van Waesberghe, Marcos Francisco Vidal Melo, Bibiana Vitković, Luigi Vivona, Marcela Vizcaychipi, Carlo Alberto Volta, Anne Weber, Toby N. Weingarten, Jakob Wittenstein, Piet Wyffels, Julio Yagüe, David Yates, Ayşen Yavru, Lilach Zac, Jing Zhong, Anesthesiology, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, ACS - Diabetes & metabolism, ACS - Microcirculation, Campos, Niklas S, Bluth, Thoma, Hemmes, Sabrine N T, Librero, Julian, Pozo, Natividad, Ferrando, Carlo, Ball, Lorenzo, Mazzinari, Guido, Pelosi, Paolo, Gama de Abreu, Marcelo, Schultz, Marcus J, Serpa Neto, A, investigators for the PROVHILO study including, Cortegiani, Andrea, Raineri, Santi Maurizio, and Giarratano, Antonino

Subjects
Adult, Lung Diseases, PEEP, postoperative pulmonary complications, mechanical ventilation, Positive-Pressure Respiration, surgery, Anesthesiology and Pain Medicine, Postoperative Complications, Tidal Volume, Humans, Postoperative Period, Lung, Randomized Controlled Trials as Topic
Abstract

BACKGROUND: High intraoperative PEEP with recruitment manoeuvres may improve perioperative outcomes. We re-examined this question by conducting a patient-level meta-analysis of three clinical trials in adult patients at increased risk for postoperative pulmonary complications who underwent non-cardiothoracic and non-neurological surgery. METHODS: The three trials enrolled patients at 128 hospitals in 24 countries from February 2011 to February 2018. All patients received volume-controlled ventilation with low tidal volume. Analyses were performed using one-stage, two-level, mixed modelling (site as a random effect; trial as a fixed effect). The primary outcome was a composite of postoperative pulmonary complications within the first week, analysed using mixed-effect logistic regression. Pre-specified subgroup analyses of nine patient characteristics and seven procedure and care-delivery characteristics were also performed. RESULTS: Complete datasets were available for 1913 participants ventilated with high PEEP and recruitment manoeuvres, compared with 1924 participants who received low PEEP. The primary outcome occurred in 562/1913 (29.4%) participants randomised to high PEEP, compared with 620/1924 (32.2%) participants randomised to low PEEP (unadjusted odds ratio [OR]=0.87; 95% confidence interval [95% CI], 0.75-1.01; P=0.06). Higher PEEP resulted in 87/1913 (4.5%) participants requiring interventions for desaturation, compared with 216/1924 (11.2%) participants randomised to low PEEP (OR=0.34; 95% CI, 0.26-0.45). Intraoperative hypotension was associated more frequently (784/1913 [41.0%]) with high PEEP, compared with low PEEP (579/1924 [30.1%]; OR=1.87; 95% CI, 1.60-2.17). CONCLUSIONS: High PEEP combined with recruitment manoeuvres during low tidal volume ventilation in patients undergoing major surgery did not reduce postoperative pulmonary complications. CLINICAL TRIAL REGISTRATION: NCT03937375 (Clinicaltrials.gov).

Published
2022

12. Generalized height-diameter models with random effects for natural forests of central Mexico

Author

Ernesto Alonso Rubio Camacho, Sacramento Corral Rivas, Juan Antonio López Hernández, Álvaro Agustín Chávez Durán, Jaqueline Xelhuantzi Carmona, and Jürgen Nagel

Subjects
Quercus, mixed-effects, Forestry, Pinus, calibration, cross-validation, Pinus patula, Abies religiosa
Abstract

Background: Tree height is an important variable in forestry, as it is commonly used to estimate volume and biomass, and to evaluate site productivity. In this study, we developed four generalized equations to model height-diameter ( h-d) relationships for coniferous and broadleaf species. For this purpose, we used information from 49 permanent sampling plots located in the natural forests of Puebla, Mexico. Non-linear fixed and mixed-effects modeling approaches were used to fit generalized versions of the Gompertz function to Pinus patula and the Pinus group, the Näslund function to Abies religiosa, and the Curtis function to the Quercus group. Results: Stand variables included in the models were the number of trees per hectare ( N), quadratic mean diameter ( dg), and basal area per hectare ( G). The results showed a model efficiency (EF) = 0.91 and root mean square error (RMSE) = 2.04 for P. patula, as well as an EF = 0.91 and RMSE = 1.63 for the Pinus group. The EF and RMSE for Abies religiosa were 0.88 and 2.21, while for the Quercus group these values were 0.72 and 1.9, respectively. From the mixed-effects model calibration, only a sub-sample of three trees from different quantiles of the diameter distribution is required to make accurate predictions. No stand-level variables related to tree height are included in any of the selected models, thus no additional measurements beyond tree diameter are required. Conclusion: Compared to conventional non-linear least squares (ONLS), mixed-effects models are more flexible and accurate and represent a new tool for sustainable forest management of natural forests in the study area.

Published
2022

13. Ischemic Heart Disease

Author

Saraí López De Lucio and Marco Antonio López Hernández

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Cardiology, medicine, Disease, business, Ischemic heart
Abstract

All over the world ischemic heart disease remains as the leading cause of death, followed by stroke. Ischemic heart disease, also called coronary artery disease has a broad spectrum of clinical manifestations from the acute coronary syndromes which include, unstable angina pectoris and acute myocardial infarction with and without elevation of the ST segment and chronic coronary disease. In patients with diabetes mellitus the cardiovascular complications mainly ischemic heart disease, are the main cause of morbidity and mortality. However, in population-based studies, the risk of heart failure in patients with diabetes mellitus is significantly increased following adjustment for well-established heart failure risk factors such as hypertension or ischemic heart disease. Ischemic heart failure angiographically diagnosed is associated with a shorter survival than non-ischemic heart failure. Coronary artery disease is independently associated with higher mortality.

Published
2021

14. Áreas de conservación en subcuencas aportadoras del sistema hidroeléctrico Grijalva, México

Author

Itzel Castro Mendoza, Walter López Báez, Marcos Antonio López Hernández, and Luis Fernando Guillén Villar

Subjects
Hydraulic engineering, TC1-978, Environmental engineering, TA170-171
Abstract

El Fondo Semilla de Agua busca aumentar la efectividad de la inversión en la conservación de seis subcuencas para disminuir el azolvamiento de las presa Chicoasén y La Angostura en Chiapas, México. Para ello se calcula la aportación de sedimentos y erosión de cada subcuenca a las presas a través de la plataforma Soil and Water Assessment Tool, (SWAT) y de álgebra de mapas para la Ecuación Universal de Pérdida de Suelo (EUPS), respectivamente, lo anterior como insumo del taller de generación de criterios para seleccionar los sitios más adecuados a conservar. La superficie total del área de estudio es de 850770 ha de las cuales solo es sujeta a conservación 120 759,18 ha, es decir el 14%. . Palabras claves: conservación, erosión, presas, sedimentos, subcuencas.

Published
2015

15. Nonalcoholic Fatty Liver Disease

Author

Marco Antonio López Hernández

Subjects
medicine.medical_specialty, business.industry, Internal medicine, InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, Nonalcoholic fatty liver disease, Medicine, business, medicine.disease, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Gastroenterology
Published
2019

16. Acute Kidney Injury in Cirrhosis

Author

Marco Antonio López Hernández

Subjects
medicine.medical_specialty, Cirrhosis, business.industry, Internal medicine, Acute kidney injury, Medicine, business, medicine.disease, Gastroenterology
Published
2018

18. [Long-term destiny of adolescents and young adults with de novo acute lymphoblastic leukemia treated with a pediatric protocol type]

Author

Manuel Antonio, López-Hernández, Martha, Alvarado-Ibarra, José Luis, Álvarez-Veral, Maricela, Ortiz-Zepeda, Martha Lilia, Guajardo-Leal, and Xochitl, Cota-Range

Subjects
Adult, Male, Adolescent, Mercaptopurine, Daunorubicin, Cytarabine, Induction Chemotherapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Dexamethasone, Disease-Free Survival, Maintenance Chemotherapy, Consolidation Chemotherapy, Young Adult, Methotrexate, Treatment Outcome, Recurrence, Vincristine, Antineoplastic Combined Chemotherapy Protocols, Asparaginase, Humans, Prednisone, Female, Cyclophosphamide, Retrospective Studies
Abstract

The prognosis, in the long term, of adolescents and young adults with acute de novo lymphoblastic leukemia, treated with a pediatric type protocol.To analyze the efficacy and tolerability of a chemotherapy regimen of pediatric type on patients 15-35 years old with de novo acute lymphoblastic leukemia, Ph(-).A retrospective study of patients received from 2001 to 2013, without initial infiltration of the central nervous system. They received the regimen called LALÍN. Terminal goals: frequency of initial remission, probability of survival free of leukemia and event-free survival for five years.We included 101 patients; there were 29 relapses and 19 deaths. There was initial remission in 97% of the cases; survival free of leukemia of 0.58 and event-free survival 0.44. No difference in patients aged 16-21 years vs. 22-35 (p0.55). Negative prognostic factors: abnormal karyotypes, except hyperdiploids (p = 0.001);5% of blasts, on 14 day induction (p = 0. 0001); delay in the punctuality of the courses of the chemotherapy regimen (p = 0.0001).A pediatric type regimen is applicable to patients aged from 16 to 35 years with acute lymphoblastic leukemia, without greater toxicity and a best survival free of leukemia. The count of5% of blasts and the delay in the execution of the stages of the chemotherapy regimen are the stronger negative prognostic factors.

Published
2016

19. Analyzing long-term average adjustment of financial ratios with spatial interactions

Author

Jesús Mur Lacambra, Mariluz Mate-Sanchez, and Fernando Antonio López Hernández

Subjects
Economics and Econometrics, Process (engineering), Spatial interaction, Convergence (routing), Econometrics, Economics, Financial ratio, Small and medium-sized enterprises, Set (psychology), Large sample, Term (time)
Abstract

The aim of this paper is to put forward a beta convergence model using spatial interaction to evaluate the dynamics of financial ratios. We overcome some of the limitations that come from the traditional partial adjustment model by relating both models. We show that the parameters of the two models may be connected. As an example, we discuss the case of a large sample of medium to high-tech industrial small and medium enterprises (SMEs) located along the Spanish Mediterranean coast. Our findings support the existence of a long-term average adjustment process in the financial ratios of this set of companies which depends on the characteristics of the firms in their neighborhood.

Published
2012

20. Survival in cardiopulmonary resuscitation due to massive pulmonary embolism: A case series in a tertiary hospital

Author

Angel Caballero, Antonio López-Hernández, Mireia Chanza, Jose Maria Gómez, Roger Pujol, Jaume Fontanals, and Marta Magaldi

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Emergency Medicine, Medicine, Cardiopulmonary resuscitation, Emergency Nursing, Cardiology and Cardiovascular Medicine, business, medicine.disease, Intensive care medicine, Pulmonary embolism
Published
2017

21. Spontaneous hypertrophic cardiomyopathy in pigs: A possible cause of misleading results in porcine models of cardiac arrest and cardiopulmonary resuscitation

Author

Jose Maria Gómez, Angel Caballero, Marta Magaldi, Joaquim Bobi, Mireia Chanza, Jaume Fontanals, and Antonio López-Hernández

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Hypertrophic cardiomyopathy, 030208 emergency & critical care medicine, 030204 cardiovascular system & hematology, Emergency Nursing, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Emergency Medicine, medicine, Cardiology, Cardiopulmonary resuscitation, Cardiology and Cardiovascular Medicine, business
Published
2017

22. Composición y diversidad de especies forestales en bosques templados de Puebla, México

Author

Jose Carlos Monarrez-Gonzalez, Marco A. González-Tagle, Juan Antonio López-Hernández, Eduardo Alanís-Rodríguez, Oscar A. Aguirre-Calderón, and Javier Jiménez-Pérez

Subjects
0106 biological sciences, Índice de Margalef, Ecology, Forest management, 010607 zoology, Diameter at breast height, Forestry, riqueza de especies, 010603 evolutionary biology, 01 natural sciences, variables estructurales, Basal area, Geography, Wiener, Dominance (ecology), Agrociencias, Ecosystem, índice de Shannon, Species richness, Tree species, Temperate rainforest
Abstract

La presente investigación se realizó con el objetivo de evaluar la composición y la diversidad de las especies forestales en bosques templados en la zona este del estado de Puebla (centro de México). La base de datos se obtuvo de 45 sitios permanentes de investigación silvícola (SPIS), ubicados en la región forestal Centro y Pico de Orizaba pertenecientes a la Unidad de Manejo Forestal, Umafor 2105. Se registró información dasométrica de altura total (m), diámetro a la altura del pecho (cm) y cobertura de copa de ejemplares con un diámetro a la altura del pecho mayor o igual a 7.5 cm. Para cada una de las especies se cuantificó su dominancia a través del área basal, su abundancia de acuerdo con el número de árboles y su frecuencia en las parcelas de muestreo. Se generó un valor ponderado para cada especie, denominado índice valor de importancia (IVI). La diversidad y la riqueza de especies se estimaron utilizando el índice de diversidad de Shannon-Wiener (H´) y el índice de Margalef (DMg). Los resultados mostraron 11 especies arbóreas, distribuidas en cinco géneros. La familia con mayor riqueza fue Pinácea, con seis especies; de las cuales P. montezumae fue la que presentó los valores mayores de densidad, área basal y área de copa seguida por A. religiosa. Para la comunidad estudiada se registró un valor de índice de Shannon-Wiener de 1.37 y uno de índice de Margalef de 1.35. Estos valores obtenidos indican tendencia a la heterogeneidad del ecosistema.

Published
2017

23. Overall survival of chronic myeloid leukemia patients treated with related donor hematopoietic stem cell transplant or imatinib

Author

Manuel Antonio, López-Hernández, Martha, Alvarado-Ibarra, and Crescencio Mauricio, González-Avante

Subjects
Adult, Male, Adolescent, Hematopoietic Stem Cell Transplantation, Antineoplastic Agents, Middle Aged, Piperazines, Survival Rate, Young Adult, Pyrimidines, Child, Preschool, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Benzamides, Imatinib Mesylate, Living Donors, Humans, Female, Longitudinal Studies, Child, Aged, Retrospective Studies
Abstract

To determine the overall survival (OS) of Ph1 positive chronic myeloid leukemia (CML) patients treated with allogeneic hematopoietic stem cell transplant (AHSCT) vs. imatinib.We retrospectively included CML patients treated with related donor myeolablative and non-myeloablative AHSCT, between 1992 and 2009. Another group consisted of a patient cohort treated with imatinib between 2001 and 2009. The main variable was the persistence of hematologic remission.The AHSCT/ imatinib groups included 36/46 patients, average age was 36/46, patients in chronic phase 34/44 and in blastic phase, 2/2. The number of myeloablative/non-myeloablative transplants was 28/8. Imatinib was administered at a dose of 400 to 800 mg/day (median 500 mg). The following events developed in both groups: death 14/3, hematological progression 4/5, 17/41 are alive and in hematological remission (p = 0.00009). The OS probability is 0.42 and 0.76 at 100 months (p = 0.0001). The decrease in absolute risk is 42%. The OS after 17 years remains unmodified in the AHSCT group after the first 6 years.OS at 100 months is superior with imatinib than with AHSCT (p = 0.0001).

Published
2012

24. [Adolescents with de novo acute lymphoblastic leukemia: efficacy and safety of a pediatric vs adult treatment protocol]

Author

Manuel Antonio, López-Hernández, Martha, Alvarado-Ibarra, Rosa María, Jiménez-Alvarado, José Enrique, De Diego-Flores, and Crescencio Mauricio, González-Avante

Subjects
Adult, Male, Young Adult, Adolescent, Clinical Protocols, Antineoplastic Combined Chemotherapy Protocols, Age Factors, Humans, Female, Precursor Cell Lymphoblastic Leukemia-Lymphoma
Abstract

To ascertain the efficacy and safety of two chemotherapy regimens, one designed for adults and the other for children, in adolescent patients with acute lymphoblastic leukemia (ALL).Between 2001-2006, we included patients aged 15-25, with de novo, Phi(-) ALL, without initial central nervous system (CNS) infiltration. Twenty patients received a chemotherapy regimen designed for children with high-risk ALL (LALIN) and twenty a regimen for adults (LALA). Both were intensive and included dexamethasone, daunorubicin, cyclophosphamide, vincristine, cytarabine, methotrexate and mercaptopurine as well as CNS prophylaxis. Elective suspension of chemotherapy occurred at two and three years respectively, in patients with continued complete remission.Patients in both groups were comparable in age, sex, presence and size of hepatosplenomegaly, initial leukocytes and platelet counts. Predominant in both groups was L2 morphology and B-cell CD10(+) immunophenotype. Results for the LALIN/ LALA groups were: failures 2/0 (p=0.49); relapses 0/4 (p= 0.05); therapy associated deaths 4/7 (p= 0.48); and event free survival at 70 months follow-up was 70% and 40% (p=0.12).In patients aged 15-25, with de novo ALL, a chemotherapy regimen designed for children had significantly less relapses than a regimen for adults. We saw no increase in toxicity in the LALIN versus the LALA group.

Published
2008

26. Experiencias del grupo de creación de nuevos materiales docentes de la UPCT en el desarrollo de libros digitales multimedia e interactivos

Author

José Miguel, Molina Martínez, primary, Daniel, García Fernández Pacheco, additional, Fernando Antonio, López Hernández, additional, Francisco, Cavas Martínez, additional, Manuel, Jiménez Buendía, additional, José Alfonso, Vera Repullo, additional, Isidoro, Guzmán Raja, additional, Pilar, Manzanares López, additional, Francisco Javier, Garrigós Guerrero, additional, Leandro, Ruiz Peñalver, additional, Francisco Javier, Cánovas Rodríguez, additional, and María Magdalena, Silva Pérez, additional

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28. El Impacto del entorno en la aplicación de las IPSAS de la IFAC al MERCOSUR

Author

Antonio López Hernandez and Carmen Caba Pérez

Subjects
contabilidad pública, sociedad, doctrina econ´´omica, Accounting. Bookkeeping, HF5601-5689
Abstract

En los últimos años, numerosos países del ámbito iberoamericano están realizando reformas en sus sistemas de información contable pública, con la intención de mejorarlos. Aunque los cambios que se operan, por lo general, toman como punto de referencia la base de devengo, se siguen encontrando bastantes discrepancias en sus prácticas contables. No obstante, esta situación podría modificarse, ya que por primera vez un organismo internacional como es la Federación Internacional de Contadores (IFAC) ha emitido una serie oficial de normas para la elaboración de informes financieros de entidades públicas que, en el caso de ser adoptadas, podrían contribuir a la armonización contable. En este contexto, en la presente comunicación se pretende poner de relieve si este nuevo marco elaborado para la contabilidad pública llevaría a los gobiernos de aquellos países que estén potenciando un espacio económico común, como es el caso del Mercosur, a plantearse la necesidad de implantarlo y, en caso positivo, especificar como afectaría el entorno actual en la introducción de las IPSAS (International Publlic Sector Accounting Standard).

Published
2012

29. Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study

Author

Berta Diaz-Feijoo, Nuria Agusti-Garcia, Raquel Sebio, Antonio López-Hernández, Marina Sisó, Ariel Glickman, Nuria Carreras-Dieguez, Pere Fuste, Tiermes Marina, Judit Martínez-Egea, Laura Aguilera, Juan Perdomo, Amaia Pelaez, Manuel López-Baamonde, Ricard Navarro-Ripoll, Elena Gimeno, Betina Campero, Aureli Torné, Graciela Martinez-Palli, and María J. Arguis

Subjects
multimodal prehabilitation, Enhanced Recovery After Surgery, advanced ovarian cancer, surgical complications, length of stay, comprehensive complications index, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: Treatment for advanced ovarian cancer (AOC) comprises cytoreductive surgery combined with chemotherapy. Multimodal prehabilitation programmes before surgery have demonstrated efficacy in postoperative outcomes in non-gynaecological surgeries. However, the viability and effects of these programmes on patients with AOC are unknown. We aimed to evaluate the feasibility and postoperative impact of a multimodal prehabilitation programme in AOC patients undergoing surgery. Methods: This single-centre, before-and-after intervention pilot study included 34 patients in two cohorts: the prehabilitation cohort prospectively included 15 patients receiving supervised exercise, nutritional optimisation, and psychological preparation from December 2019 to January 2021; the control cohort included 19 consecutive patients between January 2018 and November 2019. Enhanced Recovery After Surgery guidelines were followed. Results: The overall adherence to the multimodal prehabilitation programme was 80%, with 86.7% adherence to exercise training, 100% adherence to nutritional optimisation, and 80% adherence to psychological preparation. The median hospital stay was shorter in the prehabilitation cohort (5 (IQR, 4–6) vs. 7 days (IQR, 5–9) in the control cohort, p = 0.04). Differences in postoperative complications using the comprehensive complication index (CCI) were not significant (CCI score: 9.3 (SD 12.12) in the prehabilitation cohort vs. 16.61 (SD 16.89) in the control cohort, p = 0.08). The median time to starting chemotherapy was shorter in the prehabilitation cohort (25 (IQR, 23–25) vs. 35 days (IQR, 28–45) in the control cohort, p = 0.03). Conclusions: A multimodal prehabilitation programme before cytoreductive surgery is feasible in AOC patients with no major adverse effects, and results in significantly shorter hospital stays and time to starting chemotherapy.

Published
2022
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