231 results on '"Antonino R"'
Search Results
2. Best practices for the management of febrile seizures in children
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Alessandro Ferretti, Antonella Riva, Alice Fabrizio, Oliviero Bruni, Giuseppe Capovilla, Thomas Foiadelli, Alessandro Orsini, Umberto Raucci, Antonino Romeo, Pasquale Striano, and Pasquale Parisi
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Febrile seizure ,Children ,Management ,Prognostic factors ,Red flags ,Recommendations for caregivers ,Pediatrics ,RJ1-570 - Abstract
Abstract Febrile seizures (FS) are commonly perceived by healthcare professionals as a self-limited condition with a generally ‘benign’ nature. Nonetheless, they frequently lead to pediatric consultations, and their management can vary depending on the clinical context. For parents and caregivers, witnessing a seizure can be a distressing experience, significantly impacting their quality of life. In this review, we offer an in-depth exploration of FS management, therapeutic interventions, and prognostic factors, with the aim of providing support for physicians and enhancing communication with families. We conducted a comprehensive literature search using the PubMed and Web of Science databases, spanning the past 50 years. The search terms utilized included “febrile seizure,” “complex febrile seizure,” “simple febrile seizure,” in conjunction with “children” or “infant.” Only studies published in English or those presenting evidence-based data were included in our assessment. Additionally, we conducted a cross-reference search to identify any additional relevant data sources. Our thorough literature search resulted in a compilation of references, with carefully selected papers thoughtfully integrated into this review.
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- 2024
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3. Corrosion assessment of a bronze equestrian statue exposed to urban environment
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Es, Sebar L., primary, Iannucci, L., additional, Grassini, S., additional, Angelini, E., additional, Parvis, M., additional, Antonino, R., additional, Quaranta, G., additional, Giani, C., additional, Boassa, M., additional, and Nicola, M., additional
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- 2022
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4. Myoclonus: Differential diagnosis and current management
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Antonella Riva, Gianluca D'Onofrio, Edoardo Ferlazzo, Angelo Pascarella, Elena Pasini, Silvana Franceschetti, Ferruccio Panzica, Laura Canafoglia, Aglaia Vignoli, Antonietta Coppola, Valeria Badioni, Francesca Beccaria, Angelo Labate, Antonio Gambardella, Antonino Romeo, Giuseppe Capovilla, Roberto Michelucci, Pasquale Striano, and Vincenzo Belcastro
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electroclinical features ,epilepsy ,myoclonus ,neurophysiology ,nosology ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Myoclonus classically presents as a brief (10–50 ms duration), non‐rhythmic jerk movement. The etiology could vary considerably ranging from self‐limited to chronic or even progressive disorders, the latter falling into encephalopathic pictures that need a prompt diagnosis. Beyond the etiological classification, others evaluate myoclonus' body distribution (i.e., clinical classification) or the location of the generator (i.e., neurophysiological classification); particularly, knowing the anatomical source of myoclonus gives inputs on the observable clinical patterns, such as EMG bursts duration or EEG correlate, and guides the therapeutic choices. Among all the chronic disorders, myoclonus often presents itself as a manifestation of epilepsy. In this context, myoclonus has many facets. Myoclonus occurs as one, or the only, seizure manifestation while it can also present as a peculiar type of movement disorder; moreover, its electroclinical features within specific genetically determined epileptic syndromes have seldom been investigated. In this review, following a meeting of recognized experts, we provide an up‐to‐date overview of the neurophysiology and nosology surrounding myoclonus. Through the dedicated exploration of epileptic syndromes, coupled with pragmatic guidance, we aim to furnish clinicians and researchers alike with practical advice for heightened diagnostic management and refined treatment strategies. Plain Language Summary In this work, we described myoclonus, a movement characterized by brief, shock‐like jerks. Myoclonus could be present in different diseases and its correct diagnosis helps treatment.
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- 2024
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5. Correction to: SIRM‑SIAAIC consensus, an Italian document on management of patients at risk of hypersensitivity reactions to contrast media
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Maria Teresa Costantino, Laura Romanini, Francesco Gaeta, Fulvio Stacul, Rocco Luigi Valluzzi, Matteo Passamonti, Patrizia Bonadonna, Giovanni Cerri, Stefano Pucci, Paolo Ricci, Eleonora Savi, Michele Galluzzo, Marina Mauro, Emanuele Grassedonio, Mona Rita Yacoub, Alfonso Reginelli, Sergio Testi, Erminia Ridolo, Eustacchio Nettis, Elisabetta Di Leo, Oliviero Rossi, Paolo Montuschi, Cristoforo Incorvaia, and Antonino Romano
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2024
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6. Incidence of Retinoblastoma Has Increased: Results from 40 European Countries
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Stacey AW, Bowman R, Foster A, Kivelä TT, Munier FL, Cassoux N, Fabian ID, Al Harby L, Alarcón Portabella S, Alia DB, All-Eriksson C, Antonino R, Astbury NJ, Balaguer J, Balwierz W, Barranco H, Bascaran C, Beck Popovic M, Biewald EM, Bobrova N, Bornfeld N, Brichard BG, Blum S, Capra M, Castela G, Catala J, Chantada G, Chernodrinska VS, Cieslik K, Comsa C, Correa Llano MG, Csóka M, De Potter P, Desjardins L, Dragomir MD, Fernández-Teijeiro A, García Aldana D, Gregersen PA, Gomel N, Hadjistilianou T, Hederova S, Hummlen M, Husakova K, Ida R, Ilic VR, Jenkinson H, Kapelushnik N, Kardava T, Keren-Froim N, Kepak T, Khotenashvili Z, Klett A, Krivaitiene D, Latinovic S, Lumbroso L, Lysytsia L, Maka E, Martín Begue N, Midena E, Moll AC, Murgoi G, Naumenko L, Neroev V, Nikitovic M, Olechowski A, Papyan R, Parrozzani R, Parulekar MV, Pawinska-Wasikowska K, Peric S, Pochop P, Polyakov VG, Reddy MA, Ritter-Sovinz P, Saakyan S, Sagoo MS, San Román Pacheco S, Seregard S, Silva S, Sorochynska T, Stathopoulos C, Stirn Kranjc B, Svojgr K, Tamamyan G, Tandili A, Tateshi B, Tekavcic Pompe M, Urbak SF, Ushakova TL, Valeina S, van Hoefen Wijsard M, Veleva-Krasteva NV, Viksnins M, Wackernagel W, Wolley Dod C, Yarovaya VA, Yarovoy AA, Zhilyaeva K, Zondervan M, and Global Retinoblastoma Study Group
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Incidence ,Retinoblastoma ,Familial ,Genetic ,Fitness - Published
- 2021
7. Incidence of retinoblastoma has increased: results from 40 European countries
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UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, UCL - (SLuc) Service d'ophtalmologie, Stacey AW, BOWMAN R, FOSTER A, KIVELA TT, MUNIER F, CASSOUX N, FABIAN ID, AL HARBY L, ALARCON PORTABELLA S, ALIA DB, ALL ERIKSSON C, ANTONINO R, ASTBURY NJ, BALGAGUER J, BALWIERZ W, BARRANCO H, BASCARAN C, BECK POPOVIC M, BIEWALD EM, BOBROVA N, BORNFELD N, BRICHARD, Bénédicte, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, UCL - (SLuc) Service d'ophtalmologie, Stacey AW, BOWMAN R, FOSTER A, KIVELA TT, MUNIER F, CASSOUX N, FABIAN ID, AL HARBY L, ALARCON PORTABELLA S, ALIA DB, ALL ERIKSSON C, ANTONINO R, ASTBURY NJ, BALGAGUER J, BALWIERZ W, BARRANCO H, BASCARAN C, BECK POPOVIC M, BIEWALD EM, BOBROVA N, BORNFELD N, and BRICHARD, Bénédicte
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Incidence of retinoblastoma has increased: results from 40 European countries
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- 2021
8. Giant serpentine aneurysm: Neuroradiological and neurosurgical management in a left-handed patient
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Andrea Romano, Giulia Moltoni, Amedeo Piazza, Guido Trasimeni, Massimo Miscusi, Serena Palizzi, Allegra Romano, Antonino Raco, and Alessandro Bozzao
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Serpentine aneurysm ,Functional MRI ,Wada test ,Language dominance ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Giant serpentine aneurysms are rare huge and partially thrombosed aneurysms, with an eccentric tortuous intra-aneurysmal vascular channel. Surgical treatment is often necessary due to the great mass effect. We describe a case of a left-handed woman with a giant serpentine aneurysm of the left middle cerebral artery whose management was complex. The challenge was to exclude the aneurysm from circulation, reduce the mass effect, and, mostly, preserve the language function. Since the patient was left-handed the language dominance needed to be assessed; functional MRI (fMRI) and Wada test (WT) showed a right dominance. Surgical treatment was performed, as a complication, the patient developed left fronto-basal ischemia with a slight paresis of the right hand but without any language deficit. Our case shows the importance of a multidisciplinary team in patient management, with a pivotal role of neuroradiological functional tests in presurgical planning.
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- 2023
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9. Non-Targeted Nuclear Magnetic Resonance Analysis for Food Authenticity: A Comparative Study on Tomato Samples
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Biagia Musio, Rosa Ragone, Stefano Todisco, Antonino Rizzuti, Egidio Iorio, Mattea Chirico, Maria Elena Pisanu, Nadia Meloni, Piero Mastrorilli, and Vito Gallo
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metabolomic analysis ,NMR ,geographical origin ,method validation ,fingerprint ,inter-laboratory comparison ,Organic chemistry ,QD241-441 - Abstract
Non-targeted NMR is widely accepted as a powerful and robust analytical tool for food control. Nevertheless, standardized procedures based on validated methods are still needed when a non-targeted approach is adopted. Interlaboratory comparisons carried out in recent years have demonstrated the statistical equivalence of spectra generated by different instruments when the sample was prepared by the same operator. The present study focused on assessing the reproducibility of NMR spectra of the same matrix when different operators performed individually both the sample preparation and the measurements using their spectrometer. For this purpose, two independent laboratories prepared 63 tomato samples according to a previously optimized procedure and recorded the corresponding 1D 1H NMR spectra. A classification model was built using the spectroscopic fingerprint data delivered by the two laboratories to assess the geographical origin of the tomato samples. The performance of the optimized statistical model was satisfactory, with a 97.62% correct sample classification rate. The results of this work support the suitability of NMR techniques in food control routines even when samples are prepared by different operators by using their equipment in independent laboratories.
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- 2024
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10. Marine Environments in Front of the Ancient City of Pompeii (Southern Italy) at 79 CE: New Insights for the Unknown Location of the Harbour
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Giuseppe Aiello, Vincenzo Amato, Valeria Amoretti, Diana Barra, Mauro Antonio Di Vito, Domenico Maria Doronzo, Andrea Infante, Antonino Russo, Domenico Sparice, and Gabriel Zuchtriegel
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geoarchaeology ,geomorphology ,paleoenvironmental studies ,coastal landforms ,mediterranean ancient harbours ,Agriculture - Abstract
A multidisciplinary study, including geomorphological, stratigraphic, paleontological and archaeological methods and techniques, allowed for a detailed exploration of coastal landforms and environments in front of the ancient city of Pompeii (southern Italy). The famous site of Pompeii sits on a small volcanic hill in the alluvial-coastal plain of the Sarno River, very close to the ancient paleoshoreline. When the Roman city was buried during the eruption of Vesuvius in 79 CE, pyroclastic fall and flow deposits covered the urban centres and ancient coastal landforms. In this study, 83 new boreholes were carried out up to a depth of 10 m. Some of them (15) were analysed for their sedimentological, stratigraphical and paleontological characterisation, in order to reconstruct the sedimentary environments in 79 CE. The data collected allow for new hypotheses to be formulated regarding the paleoshorelines, as well as the 79 CE coastal landforms and environments. In particular, litho-stratigraphic and fossil assemblages highlight the presence of shallow marine environments in a large back-ridge depression, named Masseria Curati, that is located just outside the city walls. This hypothesis opens new insights on the unknown location of the harbour of the Roman city.
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- 2024
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11. Optimized Sulfonated Poly(Ether Ether Ketone) Membranes for In-House Produced Small-Sized Vanadium Redox Flow Battery Set-Up
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Antonino Rizzuti, Elena Dilonardo, Gennaro Cozzolino, Fabio Matera, Alessandra Carbone, Biagia Musio, and Piero Mastrorilli
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ion-selective membranes ,sulfonated poly(ether ether ketone) membrane ,degree of sulfonation ,SPEEK/amino–silica hybrid membrane ,vanadium redox flow battery ,chloride-based electrolyte ,Chemical technology ,TP1-1185 ,Chemical engineering ,TP155-156 - Abstract
The ionic exchange membranes represent a core component of redox flow batteries. Their features strongly affect the performance, durability, cost, and efficiency of these energy systems. Herein, the operating conditions of a lab-scale single-cell vanadium flow battery (VRFB) were optimized in terms of membrane physicochemical features and electrolyte composition, as a way to translate such conditions into a large-scale five-cell VRFB stack system. The effects of the sulfonation degree (SD) and the presence of a filler on the performances of sulfonated poly(ether ether ketone) (SPEEK) ion-selective membranes were investigated, using the commercial perfluorosulfonic-acid Nafion 115 membrane as a reference. Furthermore, the effect of a chloride-based electrolyte was evaluated by comparing it to the commonly used standard sulfuric acid electrolyte. Among the investigated membranes, the readily available SPEEK50-0 (SD = 50%; filler = 0%) resulted in it being permeable and selective to vanadium. Improved coulombic efficiency (93.4%) compared to that of Nafion 115 (88.9%) was achieved when SPEEK50-0, in combination with an optimized chloride-based electrolyte, was employed in a single-cell VRFB at a current density of 20 mA·cm−2. The optimized conditions were successfully applied for the construction of a five-cell VRFB stack system, exhibiting a satisfactory coulombic efficiency of 94.5%.
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- 2024
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12. Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement
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Bousquet, J., Akdis, C. A., Jutel, M., Bachert, C., Klimek, L., Agache, I., Ansotegui, I. J., Bedbrook, A., Bosnic-Anticevich, S., Canonica, G. W., Chivato, T., Cruz, A. A., Czarlewski, W., Del Giacco, S., Du, H., Fonseca, J. A., Gao, Y., Haahtela, T., Hoffmann-Sommergruber, K., Ivancevich, J. -C., Khaltaev, N., Knol, E. F., Kuna, P., Larenas-Linnemann, D., Mullol, J., Naclerio, R., Ohta, K., Okamoto, Y., O'Mahony, L., Onorato, G. L., Papadopoulos, N. G., Pfaar, O., Samolinski, B., Schwarze, J., Toppila-Salmi, S., Ventura, M. -T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Pawankar, R., Mubeccel, A., Mona, A. -A., Emilio, A. C., Hasan, A., Cristina, A. M., Zeinab, A., Mostafa, B. E., Sergio, B., Cristina, B., Eric, B., Bianca, B., Elisabeth, B., Larl-Christian, B., David, B., Leif, B., Attilio, B., Isabelle, B., Jacques, B., Louis-Philippe, B., Fulvio, B., Christopher, B., Roland, B., Carmen, B., Andrew, B., William, B., Fernan, C. -F., Davide, C., Silvia, C., Paulo, C., Walter, C., Vicky, C., Kai-Hakon, C., Warner, C., Thomas, C., Lorenzo, C., Alfonso, C. M., Niels, C., Ekaterine, C., George, C., Derek, C., Cemal, C., Giorgio, C., Ieva, C., Sousa Jaime, C. D., Maria del Carmen, C. D., Andre, C., Linda, C., Alvaro, C., Adnan, C., Ulf, D., Frederic, D. B., Diana, D., Pascal, D., Philippe, D., Alain, D., Ratko, D., Maria, D. C. T., Dejan, D., Ruta, D., Stephen, D., Patrik, E., Yehia, E. -G., Regina, E., Bieren Julia, E. -V., Alessandro, F., Wytske, F., Mina, G., Luis, G. R. J., Bilun, G., Sonya, G., Jose, G., Maximiliano, G., Maia, G., Ineta, G., Marta, G., Antonieta, G. M., Adnan, H., Elham, H., Jonathan, H., Martin, H., Yunuen, H. V., Guido, I., Carla, I., Zhanat, I., Edgardo, J., Ewa, J., Erika, J. -J., Sebastian, J., Guy, J., Ki-Suck, J., Jocelyne, J., Igor, K., Omer, K., Fuat, K., Przemyslaw, K., Jussi, K., Jorg, K. -T., Gerard, K., Marek, K., Mikael, K., Violeta, K., Amir, L., Susanne, L., Lan, L., Marcus, L., Michael, L., Jing, L., Philip, L., Brian, L., Karin, L. C., Bassam, M., Mika, M., Hans-Jorgen, M., Gailen, M., Pedro, M., Mohammad, M., Juan-Jose, M., Cem, M., Erik, M., Eli, M., Hans, M., Jean-Pierre, M., Florin, M., Neven, M., Branislava, M., Yousser, M., Mathieu, M., Mario, M. -A., Ralph, M., Lars, M., Antonella, M., Tihomir, M., Alla, N., Leyla, N. -B., Kristof, N., Laurent, N., Robyn, O., Kimihiro, O., Brian, O., Luigi, P. P., Isabella, P. -S., Petr, P., Nilos, P., Sim, P. H., Ruby, P., Ana, P., Bernard, P., Constantinos, P., Davor, P., Wolfgang, P., Todor, P., Fabienne, P., Paul, P., Lars, P., Emmanuel, P., Claus, R., Stella, R. M., Janet, R., Jose Angelo, R., Graham, R., Nicolas, R., Antonino, R., Jose, R. -P., Nelson, R., Lanny, R., Philip, R., Dermot, R., Mario, S. -B., Joaquin, S. -D., Glenis, S., Elie, S., Nikolaos, S., Estelle, S., Juan-Carlos, S., Dirceu, S., Talant, S., Manuel, S. -M., Cristiana, S., Rafael, S., Timo, S., Charlotte, S. U., Carel, T., Peter-Valentin, T., Massimo, T., Ioana, T., Marilyn, U. P., Erkka, V., Eric, V. G., Marianne, V. H., Olivier, V., Petra, V., Martin, W., Dana, W., Yun, W. D., Susan, W., Magnus, W., Dennis, W., Barbara, Y., Arzu, Y., Osman, Y., Mario, Z., Mihaela, Z., Beghe', Bianca, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, Helsinki University Hospital Area, Bousquet, J., Akdis, C., Jutel, M., Bachert, C., Klimek, L., Agache, I., Ansotegui, I. J., Bedbrook, A., Bosnic-Anticevich, S., Canonica, G. W., Chivato, T., Cruz, A. A., Czarlewski, W., Del Giacco, S., Du, H., Fonseca, J. A., Gao, Y., Haahtela, T., Hoffmann-Sommergruber, K., Ivancevich, J. C., Khaltaev, N., Knol, E. F., Kuna, P., Larenas-Linnemann, D., Mullol, J., Naclerio, R., Ohta, K., Okamoto, Y., O'Mahony, L., Onorato, G. L., Papadopoulos, N. G., Pfaar, O., Samolinski, B., Schwarze, J., Toppila-Salmi, S., Teresa Ventura, M., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Universitätsmedizin Berlin, Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, CharitéHumboldt-Universität zu BerlinBerlin, Germany, University Hospital Montpellier, France, MACVIA-France, Montpellier, France, Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland, Department of Clinical Immunology, Wrocław Medical University, ALL-MED Medical Research Institute, Wroclaw, Poland, Upper Airways Research Laboratory, ENT Dept, Ghent University Hospital, Ghent, Belgium, Center for Rhinology and Allergology, Wiesbaden, Germany, Transylvania University BrasovBrasov, Romania, Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia, Erandio, Spain, Woolcock Institute of Medical Research, University of Sydney, Woolcock Emphysema Centre, Sydney Local Health District, NSW, Australia, Personalized Medicine Clinic Asthma & Allergy, Humanitas University, Humanitas Research Hospital, Rozzano, Milan, Italy, Department of Biomedical Sciences, Humanitas University, MI, Pieve Emanuele, Italy, School of Medicine, University CEU San PabloMadrid, Spain, 3ProAR - Nucleo de Excelencia em Asma, Federal University of Bahia, Brasil and WHO GARD Planning Group, Salvador, Brazil, Medical Consulting Czarlewski, Montpellier, France, Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital 'Duilio Casula', University of Cagliari, Cagliari, Italy, Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, University of Science and Technology, Wuhan, Hubei, China, Center for research in health technologies and information systems- CINTESIS, Universidade do PortoPorto, Portugal, Allergy Unit, Instituto CUF Porto e Hospital CUF PortoPorto, Portugal, Health Information and Decision Sciences Department - CIDES, Faculdade de Medicina, Universidade do PortoPorto, Portugal, Faculdade de Medicina da Universidade do PortoPorto, Portugal, Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland, Department of Pathophysiology and Allergy Research, Medical University of ViennaVienna, Austria, Servicio de Alergia e Immunologia, Clinica Santa IsabelBuenos Aires, Argentina, Geneva, Switzerland, Departments of Immunology and Dermatology/Allergology, University Medical Center UtrechtUtrecht, Netherlands, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Poland, Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and HospitalMéxico City, Mexico, Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Spain, Johns Hopkins School of Medicine, Baltimore, MD, United States, National Hospital Organization, Tokyo National HospitalTokyo, Japan, Dept of Otorhinolaryngology, Chiba University HospitalChiba, Japan, Departments of Medicine and Microbiology, University College Cork, Cork, Ireland, Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of ManchesterManchester, United Kingdom, Allergy Dpt, Pediatric Clinic, University of Athens, Athens, Greece, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Germany, Department of Prevention of Envinronmental Hazards and Allergology, Medical University of Warsaw, Poland, Centre for Inflammation Research, Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom, University of Bari Medical School, Unit of Geriatric ImmunoallergologyBari, Italy, Vilnius University, Faculty of Medicine, Institute of Clinical Medicine &, Institute of Health SciencesVilnius, Lithuania, European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium, Celal Bayar University, Department of PulmonologyManisa, Turkey, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin Institute of Health, Comprehensive Allergy-Centre, Department of Dermatology and AllergyBerlin, Germany, AII - Inflammatory diseases, and Ear, Nose and Throat
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Statement (logic) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,education ,medicine.disease_cause ,Article ,corticosteroids ,03 medical and health sciences ,0302 clinical medicine ,Allergic ,Adrenal Cortex Hormones ,Administration, Intranasal ,Humans ,SARS-CoV-2 ,COVID-19 ,Rhinitis, Allergic ,medicine ,Immunology and Allergy ,biologics ,030223 otorhinolaryngology ,Coronavirus ,Rhinitis ,business.industry ,chronic rhinosinusitis ,allergy ,3. Good health ,030228 respiratory system ,Intranasal ,3121 General medicine, internal medicine and other clinical medicine ,Administration ,Nasal administration ,business - Published
- 2020
13. Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement
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Bousquet, J. Akdis, C.A. Jutel, M. Bachert, C. Klimek, L. Agache, I. Ansotegui, I.J. Bedbrook, A. Bosnic-Anticevich, S. Canonica, G.W. Chivato, T. Cruz, A.A. Czarlewski, W. Del Giacco, S. Du, H. Fonseca, J.A. Gao, Y. Haahtela, T. Hoffmann-Sommergruber, K. Ivancevich, J.-C. Khaltaev, N. Knol, E.F. Kuna, P. Larenas-Linnemann, D. Mullol, J. Naclerio, R. Ohta, K. Okamoto, Y. O’Mahony, L. Onorato, G.L. Papadopoulos, N.G. Pfaar, O. Samolinski, B. Schwarze, J. Toppila-Salmi, S. Ventura, M.-T. Valiulis, A. Yorgancioglu, A. Zuberbier, T. Pawankar, R. Mubeccel, A. Mona, A.-A. Emilio, A.C. Hasan, A. Cristina, A.M. Zeinab, A. Mostafa, B.E. Sergio, B. Cristina, B. Eric, B. Bianca, B. Elisabeth, B. Larl-Christian, B. David, B. Leif, B. Attilio, B. Sergio, B. isabelle, B. Jacques, B. Louis-Philippe, B. Fulvio, B. Christopher, B. Roland, B. Carmen, B. Andrew, B. William, B. Fernan, C.-F. Davide, C. Silvia, C. Paulo, C. Walter, C. Vicky, C. Kai-Hakon, C. Warner, C. Thomas, C. Lorenzo, C. Alfonso, C.M. Niels, C. Ekaterine, C. George, C. Derek, C. Cemal, C. Giorgio, C. Ieva, C. Sousa Jaime, C.D. Maria del Carmen, C.D. André, C. Linda, C. Alvaro, C. Adnan, C. Ulf, D. Frédéric, D.B. Diana, D. Pascal, D. Philippe, D. Alain, D. Ratko, D. Maria, D.C.T. Dejan, D. Ruta, D. Stephen, D. Patrik, E. Yehia, E.-G. Regina, E. Bieren Julia, E.-V. Alessandro, F. Wytske, F. Mina, G. Luis, G.R.J. Bilun, G. Sonya, G. José, G. Maximiliano, G. Maia, G. Ineta, G. Marta, G. Antonieta, G.M. Adnan, H. Elham, H. Jonathan, H. Martin, H. Yunuen, H.V. Guido, I. Carla, I. Zhanat, I. Edgardo, J. Ewa, J. Erika, J.-J. Sebastian, J. Guy, J. Ki-Suck, J. Jocelyne, J. Igor, K. Omer, K. Fuat, K. Przemyslaw, K. Jussi, K. Jorg, K.-T. Gerard, K. Marek, K. Mikael, K. Violeta, K. Amir, L. Susanne, L. Lan, L. Marcus, L. Michael, L. Jing, L. Philip, L. Brian, L. Karin, L.C. Bassam, M. Mika, M. Hans-Jorgen, M. Gailen, M. Pedro, M. Mohammad, M. Juan-José, M. Cem, M. Erik, M. Eli, M. Hans, M. Jean-Pierre, M. Florin, M. Neven, M. Branislava, M. Yousser, M. Mathieu, M. Mario, M.-A. Ralph, M. Lars, M. Antonella, M. Tihomir, M. Alla, N. Leyla, N.-B. Kristof, N. Laurent, N. Robyn, O. Kimihiro, O. Brian, O. Luigi, P.P. Isabella, P.-S. Petr, P. Nilos, P. Sim, P.H. Ruby, P. Ana, P. Bernard, P. Constantinos, P. Davor, P. Wolfgang, P. Todor, P. Fabienne, P. Paul, P. Lars, P. Emmanuel, P. Claus, R. Stella, R.M. Janet, R. José Angelo, R. Graham, R. Nicolas, R. Antonino, R. Jose, R.-P. Nelson, R. Lanny, R. Philip, R. Dermot, R. Mario, S.-B. Joaquin, S.-D. Glenis, S. Elie, S. Nikolaos, S. Estelle, S. Juan-Carlos, S. Dirceu, S. Talant, S. Manuel, S.-M. Cristiana, S. Rafael, S. Timo, S. Charlotte, S.U. Carel, T. Peter-Valentin, T. Massimo, T. Ioana, T. Marilyn, U.P. Erkka, V. Eric, V.G. Marianne, V.H. Olivier, V. Petra, V. Martin, W. Dana, W. Yun, W.D. Susan, W. Magnus, W. Dennis, W. Barbara, Y. Arzu, Y. Osman, Y. Mario, Z. Mihaela, Z. the ARIA-MASK Study Group
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- 2020
14. Global Retinoblastoma Presentation and Analysis by National Income Level
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Fabian, ID, Abdallah, E, Abdullahi, SU, Abdulqader, RA, Boubacar, SA, Ademola-Popoola, DS, Adio, A, Afshar, AR, Aggarwal, P, Aghaji, AE, Ahmad, A, Akib, MNR, Al Harby, L, Al Ani, MH, Alakbarova, A, Portabella, SA, Al-Badri, SAF, Alcasabas, APA, Al-Dahmash, SA, Alejos, A, Alemany-Rubio, E, Bio, AIA, Carreras, YA, Al-Haddad, C, Al-Hussaini, HHY, Ali, AM, Alia, DB, Al-Jadiry, MF, Al-Jumaly, U, Alkatan, HM, All-Eriksson, C, Al-Mafrachi, AARM, Almeida, AA, Alsawidi, KM, Al-Shaheen, AASM, Al-Shammary, EH, Amiruddin, PO, Antonino, R, Astbury, NJ, Atalay, HT, Atchaneeyasakul, L-O, Atsiaya, R, Attaseth, T, Aung, TH, Ayala, S, Baizakova, B, Balaguer, J, Balayeva, R, Balwierz, W, Barranco, H, Bascaran, C, Popovic, MB, Benavides, R, Benmiloud, S, Guebessi, NB, Berete, RC, Berry, JL, Bhaduri, A, Bhat, S, Biddulph, SJ, Biewald, EM, Bobrova, N, Boehme, M, Boldt, HC, Bonanomi, MTBC, Bornfeld, N, Bouda, GC, Bouguila, H, Boumedane, A, Brennan, RC, Brichard, BG, Buaboonnam, J, Calderon-Sotelo, P, Calle Jara, DA, Camuglia, JE, Cano, MR, Capra, M, Cassoux, N, Castela, G, Castillo, L, Catala-Mora, J, Chantada, GL, Chaudhry, S, Chaugule, SS, Chauhan, A, Chawla, B, Chernodrinska, VS, Chiwanga, FS, Chuluunbat, T, Cieslik, K, Cockcroft, RL, Comsa, C, Correa, ZM, Correa Llano, MG, Corson, TW, Cowan-Lyn, KE, Csoka, M, Cui, X, Da Gama, I, Dangboon, W, Das, A, Das, S, Davanzo, JM, Davidson, A, De Potter, P, Delgado, KQ, Demirci, H, Desjardins, L, Diaz Coronado, RY, Dimaras, H, Dodgshun, AJ, Donaldson, C, Donato Macedo, CR, Dragomir, MD, Du, Y, Du Bruyn, M, Edison, KS, Sutyawan, IWE, El Kettani, A, Elbahi, AM, Elder, JE, Elgalaly, D, Elhaddad, AM, Elhassan, MMA, Elzembely, MM, Essuman, VA, Evina, TGA, Fadoo, Z, Fandino, AC, Faranoush, M, Fasina, O, Fernandez, DDPG, Fernandez-Teijeiro, A, Foster, A, Frenkel, S, Fu, LD, Fuentes-Alabi, SL, Gallie, BL, Gandiwa, M, Garcia, JL, Garcia Aldana, D, Gassant, PY, Geel, JA, Ghassemi, F, Giron, A, Gizachew, Z, Goenz, MA, Gold, AS, Goldberg-Lavid, M, Gole, GA, Gomel, N, Gonzalez, E, Gonzalez Perez, G, Gonzalez-Rodriguez, L, Garcia Pacheco, HN, Graells, J, Green, L, Gregersen, PA, Grigorovski, NDAK, Guedenon, KM, Gunasekera, DS, Gunduz, AK, Gupta, H, Gupta, S, Hadjistilianou, T, Hamel, P, Hamid, SA, Hamzah, N, Hansen, ED, Harbour, JW, Hartnett, ME, Hasanreisoglu, M, Hassan, S, Hederova, S, Hernandez, J, Carcamo Hernandez, LM, Hessissen, L, Hordofa, DF, Huang, LC, Hubbard, GB, Hummlen, M, Husakova, K, Al-Janabi, ANH, Ida, R, Ilic, VR, Jairaj, V, Jeeva, I, Jenkinson, H, Ji, X, Jo, DH, Johnson, KP, Johnson, WJ, Jones, MM, Kabesha, TBA, Kabore, RL, Kaliki, S, Kalinaki, A, Kantar, M, Kao, L-Y, Kardava, T, Kebudi, R, Kepak, T, Keren-Froim, N, Khan, ZJ, Khaqan, HA, Khauv, P, Kheir, WJ, Khetan, V, Khodabande, A, Khotenashvili, Z, Kim, JW, Kim, JH, Kiratli, H, Kivela, TT, Klett, A, Palet, JEKK, Krivaitiene, D, Kruger, M, Kulvichit, K, Kuntorini, MW, Kyara, A, Lachmann, ES, Lam, CPS, Lam, GC, Larson, SA, Latinovic, S, Laurenti, KD, Le, BHA, Lecuona, K, Leverant, AA, Li, C, Limbu, B, Quah, BL, Lopez, JP, Lukamba, RM, Lumbroso, L, Luna-Fineman, S, Lutfi, D, Lysytsia, L, Magrath, GN, Mahajan, A, Majeed, AR, Maka, E, Makan, M, Makimbetov, EK, Manda, C, Martin Begue, N, Mason, L, Mason, JO, Matende, IO, Materin, M, Mattosinho, CCDS, Matua, M, Mayet, I, Mbumba, FB, McKenzie, JD, Medina-Sanson, A, Mehrvar, A, Mengesha, AA, Menon, V, Mercado, GJVD, Mets, MB, Midena, E, Mishra, DKC, Mndeme, FG, Mohamedani, AA, Mohammad, MT, Moll, AC, Montero, MM, Morales, RA, Moreira, C, Mruthyunjaya, P, Msina, MS, Msukwa, G, Mudaliar, SS, Muma, K, Munier, FL, Murgoi, G, Murray, TG, Musa, KO, Mushtaq, A, Mustak, H, Muyen, OM, Naidu, G, Nair, AG, Naumenko, L, Roth, PAN, Nency, YM, Neroev, V, Ngo, H, Nieves, RM, Nikitovic, M, Nkanga, ED, Nkumbe, H, Nuruddin, M, Nyaywa, M, Obono-Obiang, G, Oguego, NC, Olechowski, A, Oliver, SCN, Osei-Bonsu, P, Ossandon, D, Paez-Escamilla, MA, Pagarra, H, Painter, SL, Paintsil, V, Paiva, L, Pal, BP, Palanivelu, MS, Papyan, R, Parrozzani, R, Parulekar, M, Morales, CRP, Paton, KE, Pawinska-Wasikowska, K, Pe'er, J, Pena, A, Peric, S, Pham, CTM, Philbert, R, Plager, DA, Pochop, P, Polania, RA, Polyakov, VG, Pompe, MT, Pons, JJ, Prat, D, Prom, V, Purwanto, I, Qadir, AO, Qayyum, S, Qian, J, Rahman, A, Rahman, S, Rahmat, J, Rajkarnikar, P, Ramanjulu, R, Ramasubramanian, A, Ramirez-Ortiz, MA, Raobela, L, Rashid, R, Reddy, MA, Reich, E, Renner, LA, Reynders, D, Ribadu, D, Riheia, MM, Ritter-Sovinz, P, Rojanaporn, D, Romero, L, Roy, SR, Saab, RH, Saakyan, S, Sabhan, AH, Sagoo, MS, Said, AMA, Saiju, R, Salas, B, San Roman Pacheco, S, Sanchez, GL, Sayalith, P, Scanlan, TA, Schefler, AC, Schoeman, J, Sedaghat, A, Seregard, S, Seth, R, Shah, AS, Shakoor, SA, Sharma, MK, Sherief, ST, Shetye, NG, Shields, CL, Siddiqui, SN, Cheikh, SS, Silva, S, Singh, AD, Singh, N, Singh, U, Singha, P, Sitorus, RS, Skalet, AH, Soebagjo, HD, Sorochynska, T, Ssali, G, Stacey, AW, Staffieri, SE, Stahl, ED, Stathopoulos, C, Kranjc, BS, Stones, DK, Strahlendorf, C, Suarez, MEC, Sultana, S, Sun, X, Sundy, M, Superstein, R, Supriyadi, E, Surukrattanaskul, S, Suzuki, S, Svojgr, K, Sylla, F, Tamamyan, G, Tan, D, Tandili, A, Tarrillo Leiva, FF, Tashvighi, M, Tateshi, B, Tehuteru, ES, Teixeira, LF, Teh, KH, Theophile, T, Toledano, H, Trang, DL, Traore, F, Trichaiyaporn, S, Tuncer, S, Tyau-Tyau, H, Umar, AB, Unal, E, Uner, OE, Urbak, SF, Ushakova, TL, Usmanov, RH, Valeina, S, Wijsard, MVH, Varadisai, A, Vasquez, L, Vaughan, LO, Veleva-Krasteva, NV, Verma, N, Victor, AA, Viksnins, M, Villacos Chafla, EG, Vishnevskia-Dai, V, Vora, T, Wachtel, AE, Wackernagel, W, Waddell, K, Wade, PD, Wali, AH, Wang, Y-Z, Weiss, A, Wilson, MW, Wime, ADC, Wiwatwongwana, A, Wiwatwongwana, D, Dod, CW, Wongwai, P, Xiang, D, Xiao, Y, Yam, JC, Yang, H, Yanga, JM, Yaqub, MA, Yarovaya, VA, Yarovoy, AA, Ye, H, Yousef, YA, Yuliawati, P, Zapata Lopez, AM, Zein, E, Zhang, C, Zhang, Y, Zhao, J, Zheng, X, Zhilyaeva, K, Zia, N, Ziko, OAO, Zondervan, M, Bowman, R, Fabian, ID, Abdallah, E, Abdullahi, SU, Abdulqader, RA, Boubacar, SA, Ademola-Popoola, DS, Adio, A, Afshar, AR, Aggarwal, P, Aghaji, AE, Ahmad, A, Akib, MNR, Al Harby, L, Al Ani, MH, Alakbarova, A, Portabella, SA, Al-Badri, SAF, Alcasabas, APA, Al-Dahmash, SA, Alejos, A, Alemany-Rubio, E, Bio, AIA, Carreras, YA, Al-Haddad, C, Al-Hussaini, HHY, Ali, AM, Alia, DB, Al-Jadiry, MF, Al-Jumaly, U, Alkatan, HM, All-Eriksson, C, Al-Mafrachi, AARM, Almeida, AA, Alsawidi, KM, Al-Shaheen, AASM, Al-Shammary, EH, Amiruddin, PO, Antonino, R, Astbury, NJ, Atalay, HT, Atchaneeyasakul, L-O, Atsiaya, R, Attaseth, T, Aung, TH, Ayala, S, Baizakova, B, Balaguer, J, Balayeva, R, Balwierz, W, Barranco, H, Bascaran, C, Popovic, MB, Benavides, R, Benmiloud, S, Guebessi, NB, Berete, RC, Berry, JL, Bhaduri, A, Bhat, S, Biddulph, SJ, Biewald, EM, Bobrova, N, Boehme, M, Boldt, HC, Bonanomi, MTBC, Bornfeld, N, Bouda, GC, Bouguila, H, Boumedane, A, Brennan, RC, Brichard, BG, Buaboonnam, J, Calderon-Sotelo, P, Calle Jara, DA, Camuglia, JE, Cano, MR, Capra, M, Cassoux, N, Castela, G, Castillo, L, Catala-Mora, J, Chantada, GL, Chaudhry, S, Chaugule, SS, Chauhan, A, Chawla, B, Chernodrinska, VS, Chiwanga, FS, Chuluunbat, T, Cieslik, K, Cockcroft, RL, Comsa, C, Correa, ZM, Correa Llano, MG, Corson, TW, Cowan-Lyn, KE, Csoka, M, Cui, X, Da Gama, I, Dangboon, W, Das, A, Das, S, Davanzo, JM, Davidson, A, De Potter, P, Delgado, KQ, Demirci, H, Desjardins, L, Diaz Coronado, RY, Dimaras, H, Dodgshun, AJ, Donaldson, C, Donato Macedo, CR, Dragomir, MD, Du, Y, Du Bruyn, M, Edison, KS, Sutyawan, IWE, El Kettani, A, Elbahi, AM, Elder, JE, Elgalaly, D, Elhaddad, AM, Elhassan, MMA, Elzembely, MM, Essuman, VA, Evina, TGA, Fadoo, Z, Fandino, AC, Faranoush, M, Fasina, O, Fernandez, DDPG, Fernandez-Teijeiro, A, Foster, A, Frenkel, S, Fu, LD, Fuentes-Alabi, SL, Gallie, BL, Gandiwa, M, Garcia, JL, Garcia Aldana, D, Gassant, PY, Geel, JA, Ghassemi, F, Giron, A, Gizachew, Z, Goenz, MA, Gold, AS, Goldberg-Lavid, M, Gole, GA, Gomel, N, Gonzalez, E, Gonzalez Perez, G, Gonzalez-Rodriguez, L, Garcia Pacheco, HN, Graells, J, Green, L, Gregersen, PA, Grigorovski, NDAK, Guedenon, KM, Gunasekera, DS, Gunduz, AK, Gupta, H, Gupta, S, Hadjistilianou, T, Hamel, P, Hamid, SA, Hamzah, N, Hansen, ED, Harbour, JW, Hartnett, ME, Hasanreisoglu, M, Hassan, S, Hederova, S, Hernandez, J, Carcamo Hernandez, LM, Hessissen, L, Hordofa, DF, Huang, LC, Hubbard, GB, Hummlen, M, Husakova, K, Al-Janabi, ANH, Ida, R, Ilic, VR, Jairaj, V, Jeeva, I, Jenkinson, H, Ji, X, Jo, DH, Johnson, KP, Johnson, WJ, Jones, MM, Kabesha, TBA, Kabore, RL, Kaliki, S, Kalinaki, A, Kantar, M, Kao, L-Y, Kardava, T, Kebudi, R, Kepak, T, Keren-Froim, N, Khan, ZJ, Khaqan, HA, Khauv, P, Kheir, WJ, Khetan, V, Khodabande, A, Khotenashvili, Z, Kim, JW, Kim, JH, Kiratli, H, Kivela, TT, Klett, A, Palet, JEKK, Krivaitiene, D, Kruger, M, Kulvichit, K, Kuntorini, MW, Kyara, A, Lachmann, ES, Lam, CPS, Lam, GC, Larson, SA, Latinovic, S, Laurenti, KD, Le, BHA, Lecuona, K, Leverant, AA, Li, C, Limbu, B, Quah, BL, Lopez, JP, Lukamba, RM, Lumbroso, L, Luna-Fineman, S, Lutfi, D, Lysytsia, L, Magrath, GN, Mahajan, A, Majeed, AR, Maka, E, Makan, M, Makimbetov, EK, Manda, C, Martin Begue, N, Mason, L, Mason, JO, Matende, IO, Materin, M, Mattosinho, CCDS, Matua, M, Mayet, I, Mbumba, FB, McKenzie, JD, Medina-Sanson, A, Mehrvar, A, Mengesha, AA, Menon, V, Mercado, GJVD, Mets, MB, Midena, E, Mishra, DKC, Mndeme, FG, Mohamedani, AA, Mohammad, MT, Moll, AC, Montero, MM, Morales, RA, Moreira, C, Mruthyunjaya, P, Msina, MS, Msukwa, G, Mudaliar, SS, Muma, K, Munier, FL, Murgoi, G, Murray, TG, Musa, KO, Mushtaq, A, Mustak, H, Muyen, OM, Naidu, G, Nair, AG, Naumenko, L, Roth, PAN, Nency, YM, Neroev, V, Ngo, H, Nieves, RM, Nikitovic, M, Nkanga, ED, Nkumbe, H, Nuruddin, M, Nyaywa, M, Obono-Obiang, G, Oguego, NC, Olechowski, A, Oliver, SCN, Osei-Bonsu, P, Ossandon, D, Paez-Escamilla, MA, Pagarra, H, Painter, SL, Paintsil, V, Paiva, L, Pal, BP, Palanivelu, MS, Papyan, R, Parrozzani, R, Parulekar, M, Morales, CRP, Paton, KE, Pawinska-Wasikowska, K, Pe'er, J, Pena, A, Peric, S, Pham, CTM, Philbert, R, Plager, DA, Pochop, P, Polania, RA, Polyakov, VG, Pompe, MT, Pons, JJ, Prat, D, Prom, V, Purwanto, I, Qadir, AO, Qayyum, S, Qian, J, Rahman, A, Rahman, S, Rahmat, J, Rajkarnikar, P, Ramanjulu, R, Ramasubramanian, A, Ramirez-Ortiz, MA, Raobela, L, Rashid, R, Reddy, MA, Reich, E, Renner, LA, Reynders, D, Ribadu, D, Riheia, MM, Ritter-Sovinz, P, Rojanaporn, D, Romero, L, Roy, SR, Saab, RH, Saakyan, S, Sabhan, AH, Sagoo, MS, Said, AMA, Saiju, R, Salas, B, San Roman Pacheco, S, Sanchez, GL, Sayalith, P, Scanlan, TA, Schefler, AC, Schoeman, J, Sedaghat, A, Seregard, S, Seth, R, Shah, AS, Shakoor, SA, Sharma, MK, Sherief, ST, Shetye, NG, Shields, CL, Siddiqui, SN, Cheikh, SS, Silva, S, Singh, AD, Singh, N, Singh, U, Singha, P, Sitorus, RS, Skalet, AH, Soebagjo, HD, Sorochynska, T, Ssali, G, Stacey, AW, Staffieri, SE, Stahl, ED, Stathopoulos, C, Kranjc, BS, Stones, DK, Strahlendorf, C, Suarez, MEC, Sultana, S, Sun, X, Sundy, M, Superstein, R, Supriyadi, E, Surukrattanaskul, S, Suzuki, S, Svojgr, K, Sylla, F, Tamamyan, G, Tan, D, Tandili, A, Tarrillo Leiva, FF, Tashvighi, M, Tateshi, B, Tehuteru, ES, Teixeira, LF, Teh, KH, Theophile, T, Toledano, H, Trang, DL, Traore, F, Trichaiyaporn, S, Tuncer, S, Tyau-Tyau, H, Umar, AB, Unal, E, Uner, OE, Urbak, SF, Ushakova, TL, Usmanov, RH, Valeina, S, Wijsard, MVH, Varadisai, A, Vasquez, L, Vaughan, LO, Veleva-Krasteva, NV, Verma, N, Victor, AA, Viksnins, M, Villacos Chafla, EG, Vishnevskia-Dai, V, Vora, T, Wachtel, AE, Wackernagel, W, Waddell, K, Wade, PD, Wali, AH, Wang, Y-Z, Weiss, A, Wilson, MW, Wime, ADC, Wiwatwongwana, A, Wiwatwongwana, D, Dod, CW, Wongwai, P, Xiang, D, Xiao, Y, Yam, JC, Yang, H, Yanga, JM, Yaqub, MA, Yarovaya, VA, Yarovoy, AA, Ye, H, Yousef, YA, Yuliawati, P, Zapata Lopez, AM, Zein, E, Zhang, C, Zhang, Y, Zhao, J, Zheng, X, Zhilyaeva, K, Zia, N, Ziko, OAO, Zondervan, M, and Bowman, R
- Abstract
IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. OBJECTIVES: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. DESIGN, SETTING, AND PARTICIPANTS: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. MAIN OUTCOMES AND MEASURES: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. RESULTS: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis
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- 2020
15. Thyroid metastasis from rectal adenocarcinoma involving the airway treated by crico-tracheal resection and anastomosis: the role of palliative surgery
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Piazza, Cesare, Bolzoni, Andrea, Peretti, Giorgio, and Antonelli, Antonino R.
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- 2004
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16. Damage for gain: The useful damage of the Pitcher's paradox
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Rita Chiaramonte, Gianluca Testa, Antonino Russo, Enrico Buccheri, Massimiliano Milana, Riccardo Prezioso, Vito Pavone, and Michele Vecchio
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Joint instability ,Early diagnosis ,Shoulder ,Volleyball ,Rehabilitation ,Ultrasound ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Introduction: Sport-specific adaptations of the glenohumeral joint may arise in adolescent overhead athletes who begin high-performance sports early in life. Research mainly addresses overuse injuries, leaving gaps in prevention, with adults studied more than youths. Objective: This study aims to investigate sport-adaptations of the glenohumeral joint in asymptomatic adolescent volleyball players to identify potential shoulder injury risk factors. Design: Observational study. Setting: Clinical screening campaign conducted at the Physical Medicine and Rehabilitation Unit of Policlinic Hospital in Catania, Italy. Participants: Forty asymptomatic under-16 athletes were evaluated. Interventions: Shoulder internal rotation (IR) and external rotation (ER), range of motion (ROM), total-rotation ROM, glenohumeral IR deficit (GIRD), general joint laxity using Beighton score, apprehension, relocation, O'Brian tests, and ultrasound (US) glenohumeral distance were tested bilaterally. Variables such as the player's position, the age they began the sport, limb dominance, weight, and height were also considered. Results: The median US glenohumeral distance was at 0.42 ± 0.26 cm, which is consistent with the range found in non-dislocated shoulders of a healthy non-athletic population. The ER ROM was significantly greater in the dominant shoulder than the contralateral one (P = 0.0001), and there was a significant correlation between the ER ROM of attackers and their US glenohumeral distance (P = 0.0413). Furthermore, shoulder IR ROM and US glenohumeral distance were not significantly different between the dominant and contralateral limbs (P = 0.05). None of the athletes presented GIRD. Other tests, including the Beighton score, apprehension, and relocation tests, yielded no significant differences between the dominant and contralateral limbs. Conclusions: Despite an increased shoulder ER in the dominant limb, the glenohumeral joint remains stable, suggesting that greater ROM in ER does not equate to instability in overhead athletes without hyperlaxity. Nevertheless, increased ER impacts glenohumeral distance in attacker volleyball players. This finding suggests that the shoulder morphological adaptation process starts early in attackers.
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- 2024
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17. Mindfulness meditation styles differently modulate source-level MEG microstate dynamics and complexity
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Antea D’Andrea, Pierpaolo Croce, Jordan O’Byrne, Karim Jerbi, Annalisa Pascarella, Antonino Raffone, Vittorio Pizzella, and Laura Marzetti
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microstate analysis ,brain criticality ,complexity ,mindfulness meditation ,open monitoring meditation ,focused attention meditation ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
BackgroundThe investigation of mindfulness meditation practice, classically divided into focused attention meditation (FAM), and open monitoring meditation (OMM) styles, has seen a long tradition of theoretical, affective, neurophysiological and clinical studies. In particular, the high temporal resolution of magnetoencephalography (MEG) or electroencephalography (EEG) has been exploited to fill the gap between the personal experience of meditation practice and its neural correlates. Mounting evidence, in fact, shows that human brain activity is highly dynamic, transiting between different brain states (microstates). In this study, we aimed at exploring MEG microstates at source-level during FAM, OMM and in the resting state, as well as the complexity and criticality of dynamic transitions between microstates.MethodsTen right-handed Theravada Buddhist monks with a meditative expertise of minimum 2,265 h participated in the experiment. MEG data were acquired during a randomized block design task (6 min FAM, 6 min OMM, with each meditative block preceded and followed by 3 min resting state). Source reconstruction was performed using eLORETA on individual cortical space, and then parcellated according to the Human Connect Project atlas. Microstate analysis was then applied to parcel level signals in order to derive microstate topographies and indices. In addition, from microstate sequences, the Hurst exponent and the Lempel-Ziv complexity (LZC) were computed.ResultsOur results show that the coverage and occurrence of specific microstates are modulated either by being in a meditative state or by performing a specific meditation style. Hurst exponent values in both meditation conditions are reduced with respect to the value observed during rest, LZC shows significant differences between OMM, FAM, and REST, with a progressive increase from REST to FAM to OMM.DiscussionImportantly, we report changes in brain criticality indices during meditation and between meditation styles, in line with a state-like effect of meditation on cognitive performance. In line with previous reports, we suggest that the change in cognitive state experienced in meditation is paralleled by a shift with respect to critical points in brain dynamics.
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- 2024
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18. New Axially Expandable Oblique Cage Designed for Anterior to Psoas (ATP) Approach: Indications-Surgical Technique and Clinical-Radiological Outcomes in Patients with Symptomatic Degenerative Disc Disease
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Massimo Miscusi, Sokol Trungu, Luca Ricciardi, Stefano Forcato, Antonella Mangraviti, and Antonino Raco
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OLIF ,expandable cage ,anterior lumbar approaches ,lumbar degenerative disk disease ,Medicine - Abstract
Background: Standard oblique cages cannot cover endplates side-to-side, which is an important biomechanical factor for reducing the risk of cage subsidence and for restoring correct segmental lordosis. The aim of this study is to evaluate the radiological and clinical results of a new oblique lumbar interbody fusion (OLIF) axially expandable cage. Methods: This is a prospective observational case–control study. From March 2018 to June 2020, 28 consecutive patients with lumbar degenerative disease underwent an ATP approach, with the insertion of a new axially expandable cage, which was used as a stand-alone procedure or followed by posterior percutaneous pedicle fixation. Results: Twenty-eight patients in both groups met the inclusion criteria. The mean follow-up time was 31.2 months (range of 13–37). The clinical results were not significantly different, although in the control group, two major intraoperative complications were recorded, and slight improvements in ODI and SF-36 scores were observed in the study group. The radiological results showed a less frequent incidence of subsidence and a higher rate of fusion in the study group compared to controls. Conclusions: The axially expandable oblique cage for lumbar inter body fusion, specifically designed for the ATP approach, represents an innovation and a technical improvement. The insertion and the axial expansion technique are safe and easy. The large footprint could obtain solid and effective arthrodesis, potentially reducing the risk of subsidence.
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- 2024
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19. Geometry and Symmetry of Willis’ Circle and Middle Cerebral Artery Aneurysms Development
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Carmelo Lucio Sturiale, Alba Scerrati, Luca Ricciardi, Oriela Rustemi, Anna Maria Auricchio, Nicolò Norri, Amedeo Piazza, Fabio Raneri, Alberto Benato, Alessio Albanese, Annunziato Mangiola, Donato Carlo Zotta, Giancarlo D’Andrea, Veronica Picotti, Antonino Raco, Lorenzo Volpin, and Gianluca Trevisi
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unruptured aneurysms ,ruptured status ,MCA geometry ,hypoplasia ,Medicine - Abstract
Background: A relationship between the geometry and symmetry of Willis’ circle and intracranial aneurysms was reported for anterior communicating and posterior communicating (PCom) aneurysms. A similar association with the middle cerebral artery (MCA) aneurysms instead appeared weaker. Methods: We reviewed 432 patients from six Italian centers with unilateral MCA aneurysms, analyzing the relationship between the caliber and symmetry of Willis’ circle and the presence of ruptured and unruptured presentation. CT-angiograms were evaluated to assess Willis’ circle geometrical characteristics and the MCA aneurysm side, dimension and rupture status. Results: The hypoplasia of the first segment of the anterior cerebral artery (A1) was in approximately one-quarter of patients and PCom hypoplasia was in almost 40%. About 9% had a fetal PCom ipsilaterally to the aneurysm. By comparing the aneurysmal and healthy sides, only the PCom hypoplasia appeared significantly higher in the affected side. Finally, the caliber of the internal carotid artery (ICA) and the first segment of MCA (M1) caliber were significantly greater in patients with unruptured aneurysms, and PCom hypoplasia appeared related to the incidence of an ipsilateral MCA aneurysm and its risk of rupture. Conclusions: Although according to these findings asymmetries of Willis’ circle are shown to be a risk factor for MCA aneurysm formation and rupture, the indifferent association with ipsilateral or contralateral hypoplasia remains a datum of difficult hemodynamic interpretation, thereby raising the concern that this association may be more casual than causal.
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- 2024
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20. The 'state of the art' of intraoperative neurophysiological monitoring: An Italian neurosurgical survey
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Riccardo Antonio Ricciuti, Fabrizio Mancini, Giusy Guzzi, Daniele Marruzzo, Alessandro Dario, Alessandro della Puppa, Alessandro Ricci, Andrea Barbanera, Andrea Talacchi, Andreas Schwarz, Antonino Germanò, Antonino Raco, Antonio Colamaria, Antonio Santoro, Riccardo Boccaletti, Carlo Conti, Nunzia Cenci, Christian Cossandi, Claudio Bernucci, Corrado Lucantoni, Giovanni Battista Costella, Diego Garbossa, Donato Carlo Zotta, Federico De Gonda, Felice Esposito, Flavio Giordano, Giancarlo D'Andrea, Gianluca Piatelli, Gianluigi Zona, Giannantonio Spena, Giovanni Tringali, Giuseppe Barbagallo, Carlo Giussani, Maurizio Gladi, Andrea Landi, Angelo Lavano, Letterio Morabito, Luciano Mastronardi, Marco Locatelli, Michele D'Agruma, Michele Maria Lanotte, Nicola Montano, Orazio Santo Santonocito, Angelo Pompucci, Raffaele de Falco, Franco Randi, Sara Bruscella, Ivana Sartori, Francesco Signorelli, Luigino Tosatto, Roberto Trignani, Vincenzo Esposito, Gualtiero Innocenzi, Sergio Paolini, Vincenzo Vitiello, Michele Alessandro Cavallo, and Francesco Sala
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IOM ,Awake surgery ,Eloquent areas ,PEM ,PES ,Brain tumors ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Introduction: Intraoperative Neurophysiological Monitoring (IOM) is widely used in neurosurgery but specific guidelines are lacking. Therefore, we can assume differences in IOM application between Neurosurgical centers. Research question: The section of Functional Neurosurgery of the Italian Society of Neurosurgery realized a survey aiming to obtain general data on the current practice of IOM in Italy. Materials and methods: A 22-item questionnaire was designed focusing on: volume procedures, indications, awake surgery, experience, organization and equipe. The questionnaire has been sent to Italian Neurosurgery centers. Results: A total of 54 centers completed the survey. The annual volume of surgeries range from 300 to 2000, and IOM is used in 10–20% of the procedures. In 46% of the cases is a neurologist or a neurophysiologist who performs IOM. For supra-tentorial pathology, almost all perform MEPs (94%) SSEPs (89%), direct cortical stimulation (85%). All centers perform IOM in spinal surgery and 95% in posterior fossa surgery. Among the 50% that perform peripheral nerve surgery, all use IOM. Awake surgery is performed by 70% of centers. The neurosurgeon is the only responsible for IOM in 35% of centers. In 83% of cases IOM implementation is adequate to the request. Discussion and conclusions: The Italian Neurosurgical centers perform IOM with high level of specialization, but differences exist in organization, techniques, and expertise. Our survey provides a snapshot of the state of the art in Italy and it could be a starting point to implement a consensus on the practice of IOM.
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- 2024
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21. Validation of the prevalence to incidence conversion method for healthcare associated infections in long-term care facilities.
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Costanza Vicentini, Enrico Ricchizzi, Antonino Russotto, Stefano Bazzolo, Catia Bedosti, Valentina Blengini, Dario Ceccarelli, Elisa Fabbri, Dario Gamba, Anna Maddaleno, Edoardo Rolfini, Margherita Tancredi, and Carla Maria Zotti
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Medicine ,Science - Abstract
IntroductionResidents of long-term care facilities (LTCFs) are a population at high risk of developing severe healthcare associated infections (HAIs). In the assessment of HAIs in acute-care hospitals, selection bias can occur due to cases being over-represented: patients developing HAIs usually have longer lengths of stays compared to controls, and therefore have an increased probability of being sampled in PPS, leading to an overestimation of HAI prevalence. Our hypothesis was that in LTCFs, the opposite may occur: residents developing HAIs either may have a greater chance of being transferred to acute-care facilities or of dying, and therefore could be under-represented in PPS, leading to an underestimation of HAI prevalence. Our aim was to test this hypothesis by comparing HAI rates obtained through longitudinal and cross-sectional studies.MethodsResults from two studies conducted simultaneously in four LTCFs in Italy were compared: a longitudinal study promoted by the European Centre for Disease Prevention and Control (ECDC, HALT4 longitudinal study, H4LS), and a PPS. Prevalence was estimated from the PPS and converted into incidence per year using an adapted version of the Rhame and Sudderth formula proposed by the ECDC. Differences between incidence rates calculated from the PPS results and obtained from H4LS were investigated using the Byar method for rate ratio (RR).ResultsOn the day of the PPS, HAI prevalence was 1.47% (95% confidence interval, CI 0.38-3.97), whereas the H4LS incidence rate was 3.53 per 1000 patient-days (PDs, 95% CI 2.99-4.08). Conversion of prevalence rates obtained through the PPS into incidence using the ECDC formula resulted in a rate of 0.86 per 1000 PDs (95% CI 0-2.68). Comparing the two rates, a RR of 0.24 (95% CI 0.03-2.03, p 0.1649) was found.ConclusionsThis study did not find significant differences between HAI incidence estimates obtained from a longitudinal study and through conversion from PPS data. Results of this study support the validity of the ECDC method.
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- 2024
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22. Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations
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Alessia Guarnera, Paola Valente, Luca Pasquini, Giulia Moltoni, Francesco Randisi, Chiara Carducci, Alessia Carboni, Giulia Lucignani, Antonio Napolitano, Antonino Romanzo, Daniela Longo, Carlo Gandolfo, and Maria Camilla Rossi-Espagnet
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Ophthalmology ,RE1-994 - Abstract
Congenital malformations of the eye represent a wide and heterogeneous spectrum of abnormalities that may be part of a complex syndrome or be isolated. Ocular malformation severity depends on the timing of the causative event during eye formation, ranging from the complete absence of the eye if injury occurs during the first weeks of gestation, to subtle abnormalities if the cause occurs later on. Knowledge of ocular malformations is crucial to performing a tailored imaging protocol and correctly reporting imaging findings. Together with the ophthalmologic evaluation, imaging may help frame ocular malformations and identify underlying genetic conditions. The purpose of this pictorial review is to describe the imaging features of the main ocular malformations and the related ophthalmologic findings in order to provide a clinico-radiological overview of these abnormalities to the clinical radiologist. Sight is a crucial sense for children to explore the world and relate with their parents from birth. Vision impairment or even blindness secondary to ocular malformations deeply affects children’s growth and quality of life.
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- 2024
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23. Gait analysis, trunk movements, and electromyographic patterns after minimally invasive spine surgery for lumbar instability: An observational prospective study
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Massimo Miscusi, Mariano Serrao, Luca Ricciardi, Carmela Conte, Stefano Filippo Castiglia, Giorgio Ippolito, Gianluca Coppola, Stefano Forcato, Alba Scerrati, and Antonino Raco
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Low back pain ,Spine muscle activation ,Cross-correlation ,Center of activity ,Surface electromyography ,Vertebral column ,Surgery ,RD1-811 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective: The aim of the present study was to investigate trunk kinematics and spine muscle activation during walking after minimally invasive surgery in patients with L4-L5 degenerative spondylolisthesis suffering from lumbar instability (LI). Methods: Eleven patients suffering from LI and 13 healthy controls (HC) were enrolled. Trunk kinematics and spine muscle activation patterns during walking were collected. Maximal trunk ranges of motion were also recorded from standing position. Assessments were performed pre-operatively (T0), 1 month (T1) and 3 months (T2) after MIS. Results: We found significant improvement in spine muscle activation during walking at T2 compared to T0, mainly involving right/left symmetry at the operated level (L4-L5) and up-down synchronization from L3 to S1. Significant improvements in trunk rotation nearing to the HC group during walking were also found at T2 after surgery, though no changes were observed in the maximal range of motion of the trunk during standing. Furthermore, trunk rotation improvement correlated with a lower grade of residual disability. Conclusions: Our findings indicate that trunk rotation improves after surgery, and impaired aspects of spine muscle activation can be improved with surgery. These biomechanical parameters could represent novel tools for monitoring the effect of surgery in LI and preventing impaired spine mobility and muscle activation.
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- 2024
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24. Implementation of a centralized, web-based surveillance for healthcare associated infections among residents of long-term care facilities in Italy
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Costanza Vicentini, Antonino Russotto, Stefano Bazzolo, Edoardo Rolfini, Valentina Blengini, Dario Gamba, Antonella Agodi, Martina Barchitta, Stefania Bellio, Elisa Fabbri, Silvia Forni, Enrico Ricchizzi, Giancarlo Ripabelli, Camilla Sticchi, Fortunato “Paolo” D’Ancona, and Carla Maria Zotti
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Healthcare associated infections ,Surveillance ,Long term care facilities ,Nursing homes ,Italy ,Public aspects of medicine ,RA1-1270 - Abstract
Objective: The Italian National Action Plan to contrast AMR identified among its objectives the development and implementation of a national Healthcare-Associated Infection (HAI) surveillance system based on European Centre for Disease Prevention and Control (ECDC) indications, through point prevalence surveys (PPS) of HAIs and antibiotic use in acute-care hospitals and long-term care facilities (LTCFs). We aimed to assess feasibility and appropriateness of proposed tools for a national surveillance system of HAIs and antibiotic use in LTCFs. Study design: Point prevalence survey. Methods: A pilot PPS was conducted between May–June 2022, among 15 LTCFs of 7 Italian regions. Data were collected in a single day in each LTCF, at the LTCF, ward, and resident levels, using a web-based data collection tool developed ad hoc. Data collector teams of each facility were invited to complete a questionnaire investigating opinions on the proposed tools. Results: Among 1025 included residents, the prevalence of residents with at least one HAI was 2.5% (95% CI 1.7%-3.7%) considering all HAIs and 2.2% (95% CI 1.3%–3%) without considering SARS-CoV-2 infections. The prevalence of antimicrobial use was 3% (95% CI 0.2%–4.3%). Overall, most respondents were satisfied with the web-based software, training and protocol, even though some difficulties were reported. Conclusions: A national surveillance network was established, which will facilitate future surveillance efforts. Further studies are necessary to evaluate the impact of the pandemic on HAI transmission and antibiotic use in LTCFs.
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- 2023
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25. Persistent stapedial artery and chronic otitis media
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ZANETTI, DIEGO, PIAZZA, CESARE, and ANTONELLI, ANTONINO R.
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- 2000
26. Two-step endoscopic resection of gastric leiomyomas
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Spinelli, Pasquale, Cerrai, Federico G., Cambareri, Antonino R., Meroni, Emanuele, and Pizzetti, Paolo
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- 1993
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27. Mindfulness Affects the Boundaries of Bodily Self-Representation: The Effect of Focused-Attention Meditation in Fading the Boundary of Peripersonal Space
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Salvatore Gaetano Chiarella, Riccardo De Pastina, Antonino Raffone, and Luca Simione
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mindfulness meditation ,focused-attention meditation ,peripersonal space ,bodily self ,Psychology ,BF1-990 - Abstract
Peripersonal space (PPS) is a dynamic multisensory representation of the space around the body, influenced by internal and external sensory information. The malleability of PPS boundaries, as evidenced by their expansion after tool use or modulation through social interactions, positions PPS as a crucial element in understanding the subjective experiences of self and otherness. Building on the existing literature highlighting both the cognitive and bodily effects of mindfulness meditation, this study proposes a novel approach by employing focused-attention meditation (FAM) and a multisensory audio–tactile task to assess PPS in both the extension and sharpness of its boundaries. The research hypothesis posits that FAM, which emphasizes heightened attention to bodily sensations and interoception, may reduce the extension of PPS and make its boundaries less sharp. We enrolled 26 non-meditators who underwent a repeated measure design in which they completed the PPS task before and after a 15-min FAM induction. We found a significant reduction in the sharpness of PPS boundaries but no significant reduction in PPS extension. These results provide novel insights into the immediate effects of FAM on PPS, potentially shedding light on the modulation of self–other representations in both cognitive and bodily domains. Indeed, our findings could have implications for understanding the intricate relationship between mindfulness practices and the subjective experience of self within spatial contexts.
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- 2024
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28. Unique Features of Cardiovascular Involvement and Progression in Children with Marfan Syndrome Justify Dedicated Multidisciplinary Care
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Anwar Baban, Giovanni Parlapiano, Marianna Cicenia, Michela Armando, Alessio Franceschini, Concettina Pacifico, Arianna Panfili, Gaetano Zinzanella, Antonino Romanzo, Adelaide Fusco, Martina Caiazza, Gianluigi Perri, Lorenzo Galletti, Maria Cristina Digilio, Paola Sabrina Buonuomo, Andrea Bartuli, Antonio Novelli, Massimiliano Raponi, and Giuseppe Limongelli
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Marfan Syndrome ,children ,multidisciplinary management ,variability ,multisystemic ,personalized approach ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Marfan syndrome (MIM: # 154700; MFS) is an autosomal dominant disease representing the most common form of heritable connective tissue disorder. The condition presents variable multiorgan expression, typically involving a triad of cardiovascular, eye, and skeletal manifestations. Other multisystemic features are often underdiagnosed. Moreover, the disease is characterized by age related penetrance. Diagnosis and management of MFS in the adult population are well-described in literature. Few studies are focused on MFS in the pediatric population, making the clinical approach (cardiac and multiorgan) to these cases challenging both in terms of diagnosis and serial follow-up. In this review, we provide an overview of MFS manifestations in children, with extensive revision of major organ involvement (cardiovascular ocular and skeletal). We attempt to shed light on minor aspects of MFS that can have a significant progressive impact on the health of affected children. MFS is an example of a syndrome where an early personalized approach to address a dynamic, genetically determined condition can make a difference in outcome. Applying an early multidisciplinary clinical approach to MFS cases can prevent acute and chronic complications, offer tailored management, and improve the quality of life of patients.
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- 2024
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29. Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease
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Moris Sangineto, Martina Ciarnelli, Tommaso Cassano, Antonio Radesco, Archana Moola, Vidyasagar Naik Bukke, Antonino Romano, Rosanna Villani, Hina Kanwal, Nazzareno Capitanio, Loren Duda, Carlo Avolio, and Gaetano Serviddio
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Immunometabolism ,Alzheimer's disease ,Microglia ,Dimethyl malonate ,Macrophage ,Bioenergetics ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Microglia activation drives the pro-inflammatory activity in the early stages of Alzheimer's disease (AD). However, the mechanistic basis is elusive, and the hypothesis of targeting microglia to prevent AD onset is little explored. Here, we demonstrated that upon LPS exposure, microglia shift towards an energetic phenotype characterised by high glycolysis and high mitochondrial respiration with dysfunction. Although the activity of electron transport chain (ETC) complexes is boosted by LPS, this is mostly devoted to the generation of reactive oxygen species. We showed that by inhibiting succinate dehydrogenase (SDH) with dimethyl malonate (DMM), it is possible to modulate the LPS-induced metabolic rewiring, facilitating an anti-inflammatory phenotype. DMM improves mitochondrial function in a direct way and by reducing LPS-induced mitochondrial biogenesis. Moreover, the block of SDH with DMM inhibits the recruitment of hypoxia inducible-factor 1 α (HIF-1α), which mediates the induction of glycolysis and cytokine expression. Similar bioenergetic alterations were observed in the microglia isolated from AD mice (3xTg-AD), which present high levels of circulating LPS and brain toll-like receptor4 (TLR4). Moreover, this well-established model of AD was used to show a potential effect of SDH inhibition in vivo as DMM administration abrogated brain inflammation and modulated the microglia metabolic alterations of 3xTg-AD mice. The RNA-sequencing analysis from a public dataset confirmed the consistent transcription of genes encoding for ETC subunits in the microglia of AD mice (5xFAD). In conclusion, TLR4 activation promotes metabolic changes and the pro-inflammatory activity in microglia, and SDH might represent a promising therapeutic target to prevent AD development.
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- 2023
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30. The impact of COVID-19 pandemic on surgical neuro-oncology: A survey from the Italian society of neurosurgery (SINch)
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Luca Zanin, Tamara Ius, Pier Paolo Panciani, Felice Esposito, Andrea Gori, Marco Maria Fontanella, Maria Pia Tropeano, Antonino Raco, Filippo Flavio Angileri, Giovanni Sabatino, Alessandro Olivi, Vincenzo Esposito, Federico Pessina, Edoardo Agosti, Salvatore Aiello, Denis Aiudi, Danilo Aleo, Roberto Altieri, Rosina Amoroso, Anna Maria Auricchio, Giuseppe Barbagallo, Andrea Barbanera, Giacomo Beggio, Andrea Bianco, Riccardo Boccaletti, Stefano Borsa, Giuseppe Canova, Paolo Cappabianca, Manuela Caroli, Michele Alessandro Cavallo, Francesco Certo, Marcella Chimenti, Franco Chioffi, Valentina Cioffi, Fabio Cofano, Christian Cossandi, Giancarlo D’Andrea, Raffaele De Falco, Alessandro D'Elia, Giuseppe Maria Della Pepa, Alessandro Della Puppa, Attilio Della Torre, Paolo Ferroli, Diego Garbossa, Antonino Germanò, Alessandra Giaquinta, Franco Guida, Maurizio Iacoangeli, Domenico Gerardo Iacopino, Angelo Lavano, Giuseppe Maimone, Vincenza Maiola, Rosario Mauferi, Alessandro Melatini, Mario Moro, Domenico Murrone, Giovanni Muscas, Piero Andrea Oppido, Fabrizio Pignotti, Domenico Policicchio, Piermassimo Proto, Paolo Quaglietta, Giulia Renisi, Luca Ricciardi, Francesco Romeo, Marta Rossetto, Alba Scerrati, Andreas Schwarz, Miran Skrap, Carlo Somma, Teresa Somma, Giannantonio Spena, Stefano Telera, Luigino Tosatto, Francesco Volpin, Lorenzo Volpin, and Cesare Zoia
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COVID-19 ,Neuroncology ,SINch ,Survey ,Surgery ,RD1-811 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: The COVID-19 pandemic and its impact on hospitals' activity and organization has imposed a vast change in standard neurosurgical oncology practice to accommodate for shifting resources. Aims: This investigation aims to analyse the nationwide capability in reorganizing the surgical neuro-oncological activity during the COVID-19 pandemic to evaluate whether COVID-19-pandemic influenced the surgical management in these patients. Method: A web-based dataset model organized by the Italian Neurosurgical Society (SINCh) was sent to all the Italian neurosurgical departments in May 2021, requesting to report the types and numbers of surgical procedures performed in the pre-pandemic period (from March 9th 2019 to March 9th 2020) compared to the pandemic period (from March 10th 2020 to March 10th 2021). Results: This multicentre investigation included the surgical activity of 35 Italian Neurosurgical Departments in a pre-pandemic year versus a pandemic year. During the COVID period, 699 fewer neuro-oncological patients were operated on than in the pre-COVID period. We noted a slight increase in urgency and a more severe decrease in elective and benign pathology. None of these differences was statistically significant. Surgically treated patients who tested positive for SARS-CoV-2 were 36, of which 11 died. Death was found to be COVID-related only in 2 cases. Conclusion: The reorganization of the Italian Neurosurgical Departments was able to guarantee a redistribution of the CNS tumors during the inter-pandemic periods, demonstrating that patients even in the pandemic era could be treated without compromising the efficacy and safety of the surgical procedure.
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- 2023
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31. Argumentation and explanation in the law
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Antonino Rotolo and Giovanni Sartor
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explanation ,argumentation ,legal reasoning ,defeasibility ,normative systems ,justification ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
This article investigates the conceptual connection between argumentation and explanation in the law and provides a formal account of it. To do so, the methods used are conceptual analysis from legal theory and formal argumentation from AI. The contribution and results are twofold. On the one hand, we offer a critical reconstruction of the concept of legal argument, justification, and explanation of decision-making as it has been elaborated in legal theory and, above all, in AI and law. On the other hand, we propose some definitions of explanation in the context of formal legal argumentation, showing a connection between formal justification and explanation. We also investigate the notion of stable normative explanation developed elsewhere in Defeasible Logic and extend some complexity results. Our contribution is thus mainly conceptual, and it is meant to show how notions of explanation from literature on explainable AI and legal theory can be modeled in an argumentation framework with structured arguments.
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- 2023
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32. P918: ROLE OF THE COMBINATION OF FDG PET PLUS WHOLE BODY MRI FOR STAGING PATIENTS IN HIGH RISK SMOLDERING MYELOMA: A PROSPECTIVE TRIAL
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Claudio Cerchione, Davide Nappi, Matteo Marchesini, Sonia Ronconi, Delia Cangini, Michela Ceccolini, Giacomo Feliciani, Andrea Prochowski Iamurri, Claudia Matuozzo, Fabiana Mammoli, Federica Frabetti, Giovanni Paganelli, Federica Matteucci, Caterina Pallotti, Emanuela Scarpi, Chiara Pazzi, Domenico Barone, Antonino Romeo, Giorgia Simonetti, Gerardo Musuraca, Giovanni Martinelli, and Alice Rossi
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2023
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33. P953: ROLE OF THE COMBINATION OF FDG PET PLUS WHOLE BODY MRI FOR STAGING NEWLY DIAGNOSED AND RELAPSED/REFRACTORY MULTIPLE MYELOMA: A PROSPECTIVE TRIAL
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Claudio Cerchione, Davide Nappi, Matteo Marchesini, Giacomo Feliciani, Andrea Prochowski Iamurri, Sonia Ronconi, Delia Cangini, Michela Ceccolini, Claudia Matuozzo, Fabiana Mammoli, Federica Frabetti, Giovanni Paganelli, Federica Matteucci, Caterina Pallotti, Emanuela Scarpi, Chiara Pazzi, Domenico Barone, Antonino Romeo, Giorgia Simonetti, Gerardo Musuraca, Giovanni Martinelli, and Alice Rossi
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2023
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34. Effects of yoga practice on physiological distress, fatigue and QOL in patients affected by breast cancer undergoing adjuvant radiotherapy
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Simona Micheletti, Patrizia Serra, Anna Tesei, Irene Azzali, Chiara Arienti, Valentina Ancarani, Stefania Corelli, Antonino Romeo, and Giovanni Martinelli
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Oncology ,Radiotherapy ,Breast cancer ,Yoga ,Physiological distress ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and purpose: In this study we want to evaluate the efficacy of yoga practice on dysfunctional stress, inflammation and QOL in breast cancer patients undergoing adjuvant radiotherapy. Patients and methods: Patients with stage 0 to III breast cancer were recruited before starting radiotherapy (XRT) and were randomly assigned to yoga group (YG) two times a week during XRT or control group (CG). Self-report measures of QOL, fatigue and sleep quality, and blood samples were collected at day 1 of treatment, day 15, end of treatment and 1, 3 and 6 months later. Cortisol blood level, IL6, IL10, IL1RA, TNFα and lymphocyte-to-monocyte ratio were analyzed as measures of dysfunctional stress and inflammation. Results: Patients started XRT and yoga classes in October 2019. Due to COVID-19 pandemic we closed the enrollment in March 2020. We analysed 24 patients, 12 YG and 12 CG. The analysis of blood cortisol levels revealed an interaction (p = 0.04) between yoga practice and time, in particular YG had lower cortisol levels at the end of XRT respect to CG (p-adj = 0.02). The analysis of IL-1RA revealed an interaction effect (p = 0.04) suggesting differences between groups at some time points that post-hoc tests were not able to detect. Conclusions: To our knowledge, this is the first study to evaluate the effects of yoga in a cancer population studying inflammation markers, cortisol trend and QOL during and until 6 months after XRT. This study suggests that yoga practice is able to reduce stress and inflammation levels over time. Besides including a larger number of patients to increase the power, future studies should consider other inflammatory or pro inflammatory factors and long-term yoga program to gain more evidence on yoga practice benefits.
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- 2022
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35. The mediating effect of mood spectrum on the relationship between autistic traits and catatonia spectrum
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Liliana Dell’Osso, Giulia Amatori, Barbara Carpita, Gabriele Massimetti, Benedetta Nardi, Davide Gravina, Francesca Benedetti, Chiara Bonelli, Danila Casagrande, Mario Luciano, Isabella Berardelli, Natascia Brondino, Marianna De Gregorio, Giacomo Deste, Marta Nola, Antonino Reitano, Maria Rosaria Anna Muscatello, Maurizio Pompili, Pierluigi Politi, Antonio Vita, and Mario Maj
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mood disorders ,autism ,catatonia ,autism spectrum ,mood spectrum ,catatonia spectrum ,Psychiatry ,RC435-571 - Abstract
BackgroundIn the recent years, several studies have shown a correlation between autism spectrum disorder (ASD) and catatonia. It is also known that both conditions are found to be associated with mood disorders. This study aimed to investigate the relationship between autistic traits and catatonic symptoms, as well as the potential mediating role of mood disorder spectrum in the relationship between them.MethodsThe total sample of 514 subjects was composed by four diagnostic groups, composed by patients affected by catatonia (CTN), borderline personality disorder (BPD), major depressive disorder (MDD) and healthy controls (HC). Subjects were assessed with the SCID-5-RV, the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Catatonia Spectrum (CS) and the Mood Spectrum Self-Report (MOODS-SR). Statistical analyses included Pearson’s coefficient calculation, multiple linear regression, and mediation analysis.Resultsall the correlations appear to be strongly positive and significant with the strongest coefficient emerging between AdAS Spectrum total score and CS total score (r = 0.762, p
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- 2023
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36. Urgent psychiatric consultations for suicide attempt and suicidal ideation before and after the COVID-19 pandemic in an Italian pediatric emergency setting
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Massimo Apicella, Giulia Serra, Monia Trasolini, Elisa Andracchio, Fabrizia Chieppa, Roberto Averna, Maria Elena Iannoni, Antonio Infranzi, Marianna Moro, Clotilde Guidetti, Gino Maglio, Umberto Raucci, Antonino Reale, and Stefano Vicari
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COVID ,adolescent ,mental health ,suicide ,attempt ,depression ,Psychiatry ,RC435-571 - Abstract
IntroductionSuicidal attempts (SAs) in youth have been increasing during the last decades.MethodsWe studied consultations, SA, and suicidal ideation (SI) in a pediatric emergency department (ED).ResultsFrom 1 January 2011 to 31 May 2022, 606,159 patients accessed the ED, 8,397 of who had a child psychiatry consultation (CPC). CPCs increased significantly by 11 times in the last decade (155 in 2011 vs. 1,824 in 2021, p < 0.001); CPCs for SA increased significantly by 33 times, from 6 in 2011 to 200 in 2021 (3.9% of total CPC vs. 11%, p < 0.001). While total CPCs increased constantly during the entire period (annual percent change (APC) of 21.7 from 2011 to 2021 in a 0 joinpoint model), CPCs for SA increased significantly from 2011 to 2016, were approximately stable from 2016 to 2020, and then had a peak in 2021 after the COVID-19 pandemic (APC from 2011 to 2016 of 64.1, APC of 1.2 from 2016 to 2020, and APC of 230 after 2020 in a 2-joinpoint model).DiscussionTotal CPCs in ED as well as evaluation for SA and SI increased significantly during the last decade. CPCs for SA had an additional increase after the COVID-19 pandemic. This picture warrants timely and efficient improvements in emergency settings and mental health resources.
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- 2023
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37. Editorial: Methodological issues in consciousness research
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Luca Simione, Antonino Raffone, Roumen Kirov, Morten Overgaard, Aviva Berkovich-Ohana, and Axel Cleeremans
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methodologic challenge ,self-control ,online research ,EEG ,perceptual awareness negativity ,self-awareness ,Psychology ,BF1-990 - Published
- 2023
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38. Investigating suicidality across the autistic-catatonic continuum in a clinical sample of subjects with major depressive disorder and borderline personality disorder
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Liliana Dell’Osso, Benedetta Nardi, Chiara Bonelli, Davide Gravina, Francesca Benedetti, Giulia Amatori, Simone Battaglini, Gabriele Massimetti, Mario Luciano, Isabella Berardelli, Natascia Brondino, Marianna De Gregorio, Giacomo Deste, Marta Nola, Antonino Reitano, Maria Rosaria Anna Muscatello, Maurizio Pompili, Pierluigi Politi, Antonio Vita, Claudia Carmassi, Ivan Mirko Cremone, Barbara Carpita, and Mario Maj
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catatonia spectrum ,mood disorder ,major depression disorder (MDD) ,borderline personality disorder (BPD) ,suicide ,catatonic traits ,Psychiatry ,RC435-571 - Abstract
BackgroundRecent literature has highlighted that catatonia may be more prevalent among psychiatric patients than previously thought, beginning from autism spectrum disorders (ASD), for which it has been suggested to represent a severe late consequence, but also among individuals with mood disorders and borderline personality disorder (BPD). Interestingly, one critical point shared by these conditions is the increased risk of suicidality. The aim of this study was to evaluate how the presence and the prevalence of catatonic symptoms may shape and correlate with suicidal risk in a sample of individuals with major depressive disorder (MDD) or BPD.MethodsWe recruited two clinical samples of subjects (BPD and MDD) and a control group without a diagnosis according to DSM-5 (CTL). Subjects were assessed with the catatonia spectrum (CS) and the MOODS-SR for evaluating suicidality.ResultsIn the total sample, suicidality score was significantly and positively correlated with all CS domains and CS total score. Correlation and regression analyses highlighted specific patterns of association among Catatonia spectrum domains and suicidality in the MDD and BPD group and in the total sample.ConclusionIn both disorders, higher catatonic traits are linked to higher suicidal tendencies, confirming the high risk of suicide for this population. However, different patterns of association between catatonic symptoms and suicidality were highlighted in the two disorders.
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- 2023
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39. Editorial: Rising stars in: consciousness research 2021
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Xerxes D. Arsiwalla, Narayanan Srinivasan, Luca Simione, Johannes Kleiner, and Antonino Raffone
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contents of consciousness ,sense of self ,embodied cognition ,hypnosis ,meditation ,criticality ,Psychology ,BF1-990 - Published
- 2023
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40. Evaluation of Durum Wheat Genotypes at Germination Stage under Salinity Stress
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Mauro Vaccarella, Benedetto Frangipane, Sergio Saia, Luciano Raimondo, Antonino Rigoglioso, Rosa Petralia, Marco Genduso, and Claudia Miceli
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durum wheat ,Sicilian landraces ,germination traits ,salt stress ,Plant ecology ,QK900-989 ,Animal biochemistry ,QP501-801 ,Biology (General) ,QH301-705.5 - Abstract
The aim of this work was to investigate several durum wheat genotypes (eleven landraces, two old varieties and seven modern cultivars) for salt tolerance at germination and early growth stages. Seeds were tested under two different concentrations of NaCl solution (50 mM and 100 mM) and a control (T) with distilled water. Experiments were laid out in a two-factorial design with three replications. Two-way ANOVA was performed and means were compared with Duncan’s Multiple Range test. Seven parameters were measured under laboratory conditions: germination, mean germination time, shoot length, root length, root number, shoot dry matter and root dry matter. Rusticano, with the highest value of root number (5.44), was statistically different from all other genotypes. Timilia reste bianche, Timilia reste nere, Ciciredda and Cappelli are highlighted for the best root length performance at 100 mM.
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- 2023
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41. Impact and management of drooling in children with neurological disorders: an Italian Delphi consensus
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Antonella Riva, Elisabetta Amadori, Maria Stella Vari, Alberto Spalice, Vincenzo Belcastro, Maurizio Viri, Donatella Capodiferro, Antonino Romeo, Alberto Verrotti, the Delphi panel experts’ group, and Pasquale Striano
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Drooling ,Neurological disorders ,Pediatrics ,Cerebral palsy ,Delphi ,RJ1-570 - Abstract
Abstract Background The rate of chronic drooling in children older than 4 years is 0.5%, but it rises to 60% in those with neurological disorders. Physical and psychosocial consequences lead to a reduction in the quality of Life (QoL) of affected patients; however, the problem remains under-recognized and under-treated. We conducted an Italian consensus through a modified Delphi survey to discuss the current treatment paradigm of drooling in pediatric patients with neurological disorders. Methods After reviewing the literature, a board of 10 experts defined some statements to be administered to a multidisciplinary panel through an online encrypted platform. The answers to the questions were based on a 1–5 Likert scale (1 = strongly disagree; 5 = strongly agree). The scores were grouped into 1–2 (disagreement) and 4–5 (agreement), while 3 was discarded. The consensus was reached when the sum of the disagreement or agreement was ≥75%. Results Fifteen statements covered three main topics, namely clinical manifestations and QoL, quantification of drooling, and treatment strategies. All statements reached consensus (≥75% agreement). The 55 Italian experts agreed that drooling should be assessed in all children with complex needs, having a major impact on the QoL. Attention should be paid to investigating posterior hypersalivation, which is often neglected but may lead to important clinical consequences. Given that the severity of drooling fluctuates over time, its management should be guided by the patients’ current needs. Furthermore, the relative lack of validated and universal scales for drooling quantification limits the evaluation of the response to treatment. Finally, the shared therapeutic paradigm is progressive, with conservative treatments preceding the pharmacological ones and reserving surgery only for selected cases. Conclusion This study demonstrates the pivotal importance of a multidisciplinary approach to the management of drooling. National experts agree that progressive treatment can reduce the incidence of complications, improve the QoL of patients and caregivers, and save healthcare resources. Finally, this study highlights how the therapeutic strategy should be reconsidered over time according to the available drugs on the market, the progression of symptoms, and the patients’ needs.
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- 2022
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42. Children at risk of domestic accidents when are locked up at home: the other side of COVID-19 outbreak lockdown
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Valentina Ferro, Raffaella Nacca, Mara Pisani, Sebastian Cristaldi, Maria Francesca Faa, Maria Chiara Supino, Umberto Raucci, Antonino Reale, Marta Ciofi Degli Atti, Massimiliano Raponi, Alberto Villani, and Anna Maria Musolino
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Home accidents ,COVID-19 ,Lockdown ,Children ,Emergency ,Pediatrics ,RJ1-570 - Abstract
Abstract Background We proposed to analyze thoroughly the impact of the COVID-19 lockdown (CL) in changes of profiles and in trend of the domestic accidents (DAs) in children. Methods This was a single experience, cross-sectional study conducted at the emergency department (ED) of III trauma center. We enrolled children under 18 years admitted to ED with a diagnosis of DAs comparing the CL period from 10th March 2020 to 4th May 2020 with the same period of the previous year,10th March 2019 to 4th May 2019. Results In CL period, the cumulative incidence of ED visits for DAs increased from 86.88 to 272.13 per 1,000 children and the cumulative incidence of hospitalizations for DAs increased from 409.72 to 534.48 per 1,000 children. We reported in CL a decrease in the severity of ED presentation assessed by proxy measures: the level of priority ED visits reduced by 67% in CL period (OR: 0.33; 95%CI 0.22–0.48; p
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- 2022
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43. Alert sign and symptoms for the early diagnosis of pulmonary tuberculosis: analysis of patients followed by a tertiary pediatric hospital
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Elisa Farina, Carmen D’Amore, Laura Lancella, Elena Boccuzzi, Marta Luisa Ciofi degli Atti, Antonino Reale, Paolo Rossi, Alberto Villani, Massimiliano Raponi, and Umberto Raucci
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Children ,Tuberculosis ,Early diagnosis ,Emergency ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Intercepting earlier suspected TB (Tuberculosis) cases clinically is necessary to reduce TB incidence, so we described signs and symptoms of retrospective cases of pulmonary TB and tried to evaluate which could be early warning signs. Methods We conducted a retrospective descriptive study of pulmonary TB cases in children in years 2005–2017; in years 2018–2020 we conducted a cohort prospective study enrolling patients
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- 2022
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44. Epilepsy and sleep disorders improve in adolescents and adults with Angelman syndrome: A multicenter study on 46 patients
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Sueri, Chiara, primary, Ferlazzo, Edoardo, additional, Elia, Maurizio, additional, Bonanni, Paolo, additional, Randazzo, Giovanna, additional, Gasparini, Sara, additional, D'Agostino, Tiziana, additional, Sapone, Antonino R., additional, Ascoli, Michele, additional, Bellavia, Marina A., additional, Cianci, Vittoria, additional, Gambardella, Antonio, additional, Labate, Angelo, additional, and Aguglia, Umberto, additional
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- 2017
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45. Editorial: Insights in consciousness research 2021
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Narayanan Srinivasan, Luca Simione, Xerxes D. Arsiwalla, Johannes Kleiner, and Antonino Raffone
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consciousness ,phenomenal consciousness ,complexity ,non-local ,hypnosis ,meditation ,Psychology ,BF1-990 - Published
- 2023
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46. Editorial: Security and privacy for the Internet of Things
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Antonino Rullo, Michele Ianni, and Edoardo Serra
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Internet of Things ,security ,privacy ,mobile ,network ,Electronic computers. Computer science ,QA75.5-76.95 - Published
- 2023
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47. Oligometastatic breast cancer and metastasis-directed treatment: an aggressive multimodal approach to reach the cure
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Filippo Merloni, Michela Palleschi, Chiara Casadei, Antonino Romeo, Annalisa Curcio, Roberto Casadei, Franco Stella, Giorgio Ercolani, Caterina Gianni, Marianna Sirico, Simona Cima, Samanta Sarti, Lorenzo Cecconetto, Giandomenico Di Menna, and Ugo De Giorgi
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Metastatic breast cancer (BC) is considered an incurable disease and is usually treated with palliative intent. However, about 50% of metastatic BCs present with only a few metastatic lesions and are characterized by longer overall survival. These patients, defined as oligometastatic, could benefit from a multimodal approach, which combines systemic therapy with metastasis-directed treatment (stereotactic ablative therapy or surgery). The current definition of oligometastatic seems incomplete since it is based only on imaging findings and does not include biological features, and the majority of relevant data supporting this strategy comes from retrospective or non-randomized studies. However, the chance of reaching long-term complete remission or even a cure has led to the development of randomized trials investigating the impact of combined treatment in oligometastatic BC (OMBC). The SABR-COMET trial, the first randomized study to include BC patients, showed promising results from a combination of stereotactic ablative radiotherapy and systemic therapy. Considering the randomized trial’s results, multidisciplinary teams should be set up to select OMBC patients who could achieve long-term survival with aggressive multimodal treatment.
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- 2023
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48. Trend of hoverboard related injuries at a pediatric emergency department
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Valentina Ferro, Raffaella Nacca, Elena Boccuzzi, Tatiana Federici, Chiara Ossella, Alessandra Merenda, Renato Maria Toniolo, Anna Maria Musolino, Antonino Reale, and Umberto Raucci
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Injury ,Hoverboard ,Safety ,Prevention ,Child ,Emergency ,Pediatrics ,RJ1-570 - Abstract
Abstract Introduction Understanding how the use of hoverboards (HBs) can affect a child’s safety is crucial. We describe the characteristics of HB related injuries and provide key messages about child prevention when using these leisure devices. Methods This was a retrospective study at an emergency department (ED) of a level-III-trauma center from 2016 to 2019. We tested the differences in children presenting for injury associated with HBs between 2016-2017 and 2018-2019 to better describe the temporal trend of the phenomenon. Results The rate of Injury associated with HBs / Total injury per 1,000 increased from 0.84 in 2016 to 7.7 in 2017, and then there was a gradual decline. The likelihood of injury was more common in younger children, increasing by 17% with decreasing age in 2018-2019 compared with 2016-2017 (OR: 0.83; 95%CI: 0.71-0.97; p = 0.021). The occurrence of injury in the April-June period was over twice as common in 2018-2019 (OR: 2.05; 95%CI: 1.0-2.05; p = 0.05). Patients were over 4 times more likely to have injured the lower extremity during the 2018-2019 period rather than other body regions (OR: 4.58; 95%CI: 1.23-4.58; p = 0.02). The odds of the indoor injury were more than twice as high in 2018-2019 (OR: 2.04; 95%CI: 1.077-2.04; p = 0.03). Conclusion Despite a decrease in the frequency of HB related injuries after 2017, during the 2018-2019 period, the younger the children, the more they were exposed to injury risk, in addition to a greater occurrence of indoor injuries from HBs compared with 2016-2017. The enhancement of preventive measures is necessary to ensure child safety when using HBs.
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- 2022
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49. Early recognition of child abuse through screening indicators at the emergency department: experience of a tertiary urban pediatric hospital
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Caterina Offidani, Alberto Villani, Antonino Reale, Maria Rosaria Marchili, Lelia Rotondi Aufiero, Patrizio Moras, Maria Lodise, Umberto Raucci, Maria Antonietta Barbieri, and Massimiliano Raponi
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Child abuse ,Neglect ,Maltreatment ,Sexual abuse ,Screening ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Emergency Departments play a pivotal role in detecting cases of child abuse. Despite the efforts made in the past decades on the need for a screening method for the early detection of abuse victims, a unique instrument shared by the international scientific community has not been made. These instruments should be able to help recognizing whether it is necessary to further investigate the child’s condition. The aim of the study is to illustrate the screening indicators in use since 2010 in the Emergency Department of the Bambino Gesù Children’s Hospital to early recognise the victims of abuse and the modifying process of the screening tool undertaken over the years. Methods We retrospectively analyzed the process that led to the editing of the indicators of child abuse in use nowadays at the Bambino Gesù Children's Hospital. We codified three clinical pathways to apply in case of suspected abuse. Furthermore, we investigated the medical records of screening-positive accesses in the Paediatric Emergency Department of the Bambino Gesù Children's Hospital from January 2008 to October 2020. Results An estimation of positive screening, regarding the type of abuse suspected, and the number of accessed in ED was made, resulting in a cohort of 956 patients. In 2010 we created a list of 14 items grouped in three clusters: anamnestic declarations or incongruences, carelessness/neglect and evident lesions at physical examination. Positivity to one of the items allows the actuation of the investigating protocol named as clinical pathway.In 2013, after three years of experience, the criteria were edited to increase specificity. The application of screening led to a median number of 82 suspected cases/year from 2013 to 2020. Conclusion A screening tool is essential and productive for the early recognition of victims of abuse. An in-deep analysis of suspected cases through a standardized method, such as the clinical pathway, allowed reaching the diagnosis in a more accurate and precise manner.
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- 2022
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50. Acute Pupillary Disorders in Children: A 10-Year Retrospective Study of 101 Patients
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Giacomo Garone, Marco Roversi, Mara Pisani, Francesco La Penna, Antonio Musolino, Sebastian Cristaldi, Anna Maria Musolino, Amanda Roberto, Gianni Petrocelli, Antonino Reale, Fabio Midulla, Alberto Villani, and Umberto Raucci
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pupillary motility ,mydriasis ,miosis ,children ,pediatrics ,Pediatrics ,RJ1-570 - Abstract
Background: To date, no study has specifically examined children with acute-onset pupillary motility disorders (APMD). Especially in the Emergency Department (ED), it is crucial to distinguish benign and transient conditions from life-threatening or urgent conditions (UCs). The aim of the study is to describe the clinical characteristics of children with APMD and their association with an increased risk of UCs. Methods: We conducted a pediatric retrospective study of APMD referred to ED over a 10-year period. We described the characteristics in the overall sample and in two subgroups divided according to urgency of the underlying condition. Furthermore, we applied a logistic regression model to identify the variables predictive of LT condition. Results: We analyzed 101 patients. In 59.4%, the APMD was isolated. In patients with extra-ocular involvement, the most frequently associated features were altered consciousness, headache, and vomiting. Exposure to toxic agents was reported in 48.5%. Urgent conditions occurred significantly more frequently in older children, presenting bilateral APMD and/or other ocular or extra-ocular manifestations. Conclusions: Our study shows that UCs most commonly occur in patients presenting with bilateral APMD and other associated features. In unilateral/isolated APMD ophthalmological examination, exclusion of toxic exposure and observation until resolution of symptoms should be recommended.
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- 2023
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