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3. Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys

Author

Hewei Chen, Bo Yuan, Rui Zhao, Xiao Yang, Zhanwen Xiao, Antoniac Aurora, Bita Ana Iulia, Xiangdong Zhu, Antoniac Vasile Iulian, and Xingdong Zhang

Subjects
Mg alloys, Degradability, Antibacterial property, Osteogenic ability, Bone defect repair, Mining engineering. Metallurgy, TN1-997
Abstract

The rapid degradation of magnesium (Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca (denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag (denoted as ZQ71) and Mg-0.8Ca-5Zn-2.5Ag (denoted as ZQ63), were fabricated by alloying with calcium (Ca), zinc (Zn) and silver (Ag). The results obtained from electrochemical corrosion tests and in vitro degradation evaluation demonstrated that the three Mg alloys exhibited distinct corrosion resistance, and ZQ71 exhibited the lowest degradation rate in vitro among them. After addition of Zn and Ag, the antibacterial potential of Mg alloys was also enhanced. The in vitro cell experiments showed that all the three Mg alloys had good biocompatibility. After implantation in a rat femoral defect, ZQ71 showed significantly higher osteogenic activity and bone substitution rate than ZQ63 and ZQ, due to its higher corrosion resistance as well as the stimulatory effects of the released metallic ions. In addition, the average daily degradation rate of each Mg alloy in vivo was significantly higher than that in vitro, as could be due to the implantation site located in the highly vascularized trabecular region. Importantly, the correlations between the in vitro and in vivo degradation parameters of the Mg alloys were systematically analyzed to find out the potential predictors of the in vivo degradation performance of the materials. The current work not only evaluated the clinical potential of the three biodegradable Mg alloys as bone grafts but also provided a feasible approach for predicting the in vivo degradation behavior of biodegradable materials.

Published
2022
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4. Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg–Ca–Zn–Ag alloy to inhibit bacterial infection and promote bone regeneration

Author

Bo Yuan, Hewei Chen, Rui Zhao, Xuangeng Deng, Guo Chen, Xiao Yang, Zhanwen Xiao, Antoniac Aurora, Bita Ana Iulia, Kai Zhang, Xiangdong Zhu, Antoniac Vasile Iulian, Shen Hai, and Xingdong Zhang

Subjects
Mg alloy, Composite coating, Corrosion resistance, Antibacterial ability, Osteogenic activity, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5
Abstract

The improved corrosion resistance, osteogenic activity, and antibacterial ability are the key factors for promoting the large-scale clinical application of magnesium (Mg)-based implants. In the present study, a novel nanocomposite coating composed of inner magnesium hydroxide, middle graphene oxide, and outer hydroxyapatite (Mg(OH)2/GO/HA) is constructed on the surface of Mg-0.8Ca–5Zn-1.5Ag by a combined strategy of hydrothermal treatment, electrophoretic deposition, and electrochemical deposition. The results of material characterization and electrochemical corrosion test showed that all the three coatings have high bonding strength, hydrophilicity and corrosion resistance. In vitro studies show that Mg(OH)2 indeed improves the antibacterial activity of the substrate. The next GO and GO/HA coating procedures both promote the osteogenic differentiation of MC3T3-E1 cells and show no harm to the antibacterial activity of Mg(OH)2 coating, but the latter exhibits the best promoting effect. In vivo studies demonstrate that the Mg alloy with the composite coating not only ameliorates osteolysis induced by bacterial invasion but also promotes bone regeneration under both normal and infected conditions. The current study provides a promising surface modification strategy for developing multifunctional Mg-based implants with good corrosion resistance, antibacterial ability and osteogenic activity to enlarge their biomedical applications.

Published
2022
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5. Outcomes of Birmingham Hip Resurfacing Based on Clinical Aspects and Retrieval Analysis of Failed Prosthesis.

Author

Antoniac, Iulian, Valeanu, Niculae, Niculescu, Marius, Antoniac, Aurora, Robu, Alina, Popescu, Larisa, Manescu, Veronica, Anusca, Dan, and Enachescu, Catalin Ionel

Subjects
TOTAL hip replacement, MICROSCOPICAL technique, ARTIFICIAL hip joints, BONE cements, SCANNING electron microscopy, DENTAL cements
Abstract

This research aims to identify the prevalence of failure for Birmingham Hip Prosthesis (BHR) in total hip arthroplasty and to analyze its reasons from biomaterials and biofunctional perspectives. We present our current analysis and tests on a series of different BHR-retrieved prostheses after premature failure. Relevant clinical data, such as X-ray investigations and intraoperative images for clinical case studies, were analyzed to better understand all factors involved in BHR prosthesis failure. A detailed analysis of the failures highlighted uneven cement distribution, overloading in certain areas, and void formation in the material. A closer investigation using microscopical techniques revealed the presence of a crack originating from the gap between the cement mantle and human bone. Additionally, scanning electron microscopy analyses were conducted as part of the investigation to examine bone cement morphology in detail and better understand the interactions at the interfaces between implant, cement, and bone. In conclusion, this research emphasizes the importance of surgical technique planning and the cementation procedure in the success rate of BHR prostheses. It also underscores the need to carefully evaluate patient characteristics and bone quality to minimize the risk of BHR prosthesis failure. The cementation procedure seems to be essential for the long-term functionality of the BHR prosthesis. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Mechanical and Computational Fluid Dynamic Models for Magnesium-Based Implants

Author

Manescu (Paltanea), Veronica, primary, Paltanea, Gheorghe, additional, Antoniac, Aurora, additional, Gruionu, Lucian Gheorghe, additional, Robu, Alina, additional, Vasilescu, Marius, additional, Laptoiu, Stefan Alexandru, additional, Bita, Ana Iulia, additional, Popa, Georgiana Maria, additional, Cocosila, Andreea Liliana, additional, Silviu, Vlad, additional, and Porumb, Anca, additional

Published
2024
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8. Physico-Chemical Characterization and Biocompatibility Evaluation of Some Vaginal Formulations Based on Collagen and Mucoadhesive Polymers

Author

Ioana, Luca, primary, Albu Kaya, Madalina Georgiana, additional, Titorencu, Irina, additional, Dinu-Pîrvu, Cristina Elena, additional, MARIN, Maria Minodora, additional, Lacramioara, Popa, additional, Rosca, Ana Maria, additional, Antoniac, Aurora, additional, Anuta, Valentina, additional, Pristanda, Razvan Mihai, additional, and Ghica, Mihaela Violeta, additional

Published
2024
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10. Influence of Lavender Essential Oil on the Physical and Antibacterial Properties of Chitosan Sponge for Hemostatic Applications

Author

Gheorghiță, Daniela, primary, Antoniac, Iulian, additional, Moldovan, Horațiu, additional, Antoniac, Aurora, additional, Grosu, Elena, additional, Motelica, Ludmila, additional, Ficai, Anton, additional, Oprea, Ovidiu, additional, Vasile, Eugeniu, additional, Dițu, Lia Mara, additional, and Raiciu, Anca Daniela, additional

Published
2023
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11. In Vitro Studies Regarding the Effect of Cellulose Acetate-Based Composite Coatings on the Functional Properties of the Biodegradable Mg3Nd Alloys

Author

Streza, Alexandru, primary, Antoniac, Aurora, additional, Manescu (Paltanea), Veronica Manescu, additional, Ciocoiu, Robert, additional, Cotrut, Cosmin-Mihai, additional, Miculescu, Marian, additional, Miculescu, Florin, additional, Antoniac, Iulian, additional, Fosca, Marco, additional, Rau, Julietta V., additional, and Dura, Horatiu, additional

Published
2023
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14. Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys

Author

Rui Zhao, Antoniac Aurora, Hewei Chen, Antoniac Vasile Iulian, Zhanwen Xiao, Xiao Yang, Bita Ana Iulia, Bo Yuan, Xiangdong Zhu, and Xingdong Zhang

Subjects
Materials science, Biocompatibility, Alloy, chemistry.chemical_element, 02 engineering and technology, Zinc, engineering.material, 01 natural sciences, Corrosion, Metal, In vivo, 0103 physical sciences, 010302 applied physics, Magnesium, technology, industry, and agriculture, Metals and Alloys, equipment and supplies, 021001 nanoscience & nanotechnology, chemistry, Mechanics of Materials, visual_art, engineering, visual_art.visual_art_medium, Degradation (geology), 0210 nano-technology, Nuclear chemistry
Abstract

The rapid degradation of magnesium (Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca (denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag (denoted as ZQ71) and Mg-0.8Ca-5Zn-2.5Ag (denoted as ZQ63), were fabricated by alloying with calcium (Ca), zinc (Zn) and silver (Ag). The results obtained from electrochemical corrosion tests and in vitro degradation evaluation demonstrated that the three Mg alloys exhibited distinct corrosion resistance, and ZQ71 exhibited the lowest degradation rate in vitro among them. After addition of Zn and Ag, the antibacterial potential of Mg alloys was also enhanced. The in vitro cell experiments showed that all the three Mg alloys had good biocompatibility. After implantation in a rat femoral defect, ZQ71 showed significantly higher osteogenic activity and bone substitution rate than ZQ63 and ZQ, due to its higher corrosion resistance as well as the stimulatory effects of the released metallic ions. In addition, the average daily degradation rate of each Mg alloy in vivo was significantly higher than that in vitro, as could be due to the implantation site located in the highly vascularized trabecular region. Importantly, the correlations between the in vitro and in vivo degradation parameters of the Mg alloys were systematically analyzed to find out the potential predictors of the in vivo degradation performance of the materials. The current work not only evaluated the clinical potential of the three biodegradable Mg alloys as bone grafts but also provided a feasible approach for predicting the in vivo degradation behavior of biodegradable materials.

Published
2022

19. Bone Regeneration Induced by Patient-Adapted Mg Alloy-Based Scaffolds for Bone Defects: Present and Future Perspectives.

Author

Manescu, Veronica, Antoniac, Iulian, Antoniac, Aurora, Laptoiu, Dan, Paltanea, Gheorghe, Ciocoiu, Robert, Nemoianu, Iosif Vasile, Gruionu, Lucian Gheorghe, and Dura, Horatiu

Subjects
BONE regeneration, LITERATURE reviews, MAGNESIUM ions, HEALING, HEMATOPOIESIS, MAGNESIUM alloys, BIOACTIVE glasses
Abstract

Treatment of bone defects resulting after tumor surgeries, accidents, or non-unions is an actual problem linked to morbidity and the necessity of a second surgery and often requires a critical healthcare cost. Although the surgical technique has changed in a modern way, the treatment outcome is still influenced by patient age, localization of the bone defect, associated comorbidities, the surgeon approach, and systemic disorders. Three-dimensional magnesium-based scaffolds are considered an important step because they can have precise bone defect geometry, high porosity grade, anatomical pore shape, and mechanical properties close to the human bone. In addition, magnesium has been proven in in vitro and in vivo studies to influence bone regeneration and new blood vessel formation positively. In this review paper, we describe the magnesium alloy's effect on bone regenerative processes, starting with a short description of magnesium's role in the bone healing process, host immune response modulation, and finishing with the primary biological mechanism of magnesium ions in angiogenesis and osteogenesis by presenting a detailed analysis based on a literature review. A strategy that must be followed when a patient-adapted scaffold dedicated to bone tissue engineering is proposed and the main fabrication technologies are combined, in some cases with artificial intelligence for Mg alloy scaffolds, are presented with examples. We emphasized the microstructure, mechanical properties, corrosion behavior, and biocompatibility of each study and made a basis for the researchers who want to start to apply the regenerative potential of magnesium-based scaffolds in clinical practice. Challenges, future directions, and special potential clinical applications such as osteosarcoma and persistent infection treatment are present at the end of our review paper. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for Trauma

Author

Streza, Alexandru, primary, Antoniac, Aurora, additional, Manescu (Paltanea), Veronica, additional, Paltanea, Gheorghe, additional, Robu, Alina, additional, Dura, Horatiu, additional, Verestiuc, Liliana, additional, Stanica, Enache, additional, Voicu, Stefan Ioan, additional, Antoniac, Iulian, additional, Cristea, Mihai Bogdan, additional, Dragomir, Bogdan Radu, additional, Rau, Julietta V., additional, and Manolea, Maria-Magdalena, additional

Published
2023
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24. Failure Analysis of Ultra-High Molecular Weight Polyethylene Tibial Insert in Total Knee Arthroplasty

Author

Manescu (Paltanea), Veronica, primary, Antoniac, Iulian, additional, Antoniac, Aurora, additional, Paltanea, Gheorghe, additional, Miculescu, Marian, additional, Bita, Ana-Iulia, additional, Laptoiu, Stefan, additional, Niculescu, Marius, additional, Stere, Alexandru, additional, Paun, Costel, additional, and Cristea, Mihai Bogdan, additional

Published
2022
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25. Essential Oils as Antimicrobial Active Substances in Wound Dressings

Author

Gheorghita, Daniela, primary, Grosu, Elena, additional, Robu, Alina, additional, Ditu, Lia Mara, additional, Deleanu, Iuliana Mihaela, additional, Gradisteanu Pircalabioru, Gratiela, additional, Raiciu, Anca-Daniela, additional, Bita, Ana-Iulia, additional, Antoniac, Aurora, additional, and Antoniac, Vasile Iulian, additional

Published
2022
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27. Effect of the Antimicrobial Agents Peppermint Essential Oil and Silver Nanoparticles on Bone Cement Properties

Author

Robu, Alina, primary, Antoniac, Aurora, additional, Ciocoiu, Robert, additional, Grosu, Elena, additional, Rau, Julietta V., additional, Fosca, Marco, additional, Krasnyuk, Ivan I., additional, Pircalabioru, Gratiela Gradisteanu, additional, Manescu (Paltanea), Veronica, additional, Antoniac, Iulian, additional, and Gradinaru, Sebastian, additional

Published
2022
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29. Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long‐Term Time‐Resolved Studies and In Vitro Properties

Author

Rau, Julietta V., primary, Fadeeva, Inna V., additional, Forysenkova, Anna A., additional, Davydova, Galina A., additional, Fosca, Marco, additional, Filippov, Yaroslav Yu., additional, Antoniac, Iulian V., additional, Antoniac, Aurora, additional, D'Arco, Annalisa, additional, Di Fabrizio, Marta, additional, Petrarca, Massimo, additional, Lupi, Stefano, additional, Di Menno Di Bucchianico, Massimo, additional, Yankova, Viktoriya G., additional, Putlayev, Valery I., additional, and Cristea, Mihai Bogdan, additional

Published
2022
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32. Fluoride Treatment and In Vitro Corrosion Behavior of Mg-Nd-Y-Zn-Zr Alloys Type

Author

Quan, Pham Hong, primary, Antoniac, Iulian, additional, Miculescu, Florin, additional, Antoniac, Aurora, additional, (Păltânea), Veronica Manescu, additional, Robu, Alina, additional, Bița, Ana-Iulia, additional, Miculescu, Marian, additional, Saceleanu, Adriana, additional, Bodog, Alin Dănuț, additional, and Saceleanu, Vicentiu, additional

Published
2022
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33. Additives Imparting Antimicrobial Properties to Acrylic Bone Cements

Author

Robu, Alina, primary, Antoniac, Aurora, additional, Grosu, Elena, additional, Vasile, Eugeniu, additional, Raiciu, Anca Daniela, additional, Iordache, Florin, additional, Antoniac, Vasile Iulian, additional, Rau, Julietta V., additional, Yankova, Viktoriya G., additional, Ditu, Lia Mara, additional, and Saceleanu, Vicentiu, additional

Published
2021
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38. BiomMedD V

Author

Antoniac, Iulian, primary, Cotruț, Cosmin Mihai, additional, and Antoniac, Aurora, additional

Published
2013
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39. Comparative framework of calcium phosphates-based products derived from sustainable marine and terrestrial resources for biomedical applications

Author

Mocanu, Aura-Cătălina, primary, Miculescu, Marian, additional, Ciocoiu, Robert-Cătălin, additional, Butte, Tudor-Mihai, additional, Biță, Ana-Iulia, additional, Milea, Claudia-Georgiana, additional, Antoniac, Aurora, additional, Vasilescu, Marius, additional, Trante, Octavian, additional, Pop, Ciprian, additional, and Ciocan, Lucian-Toma, additional

Published
2020
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43. New Pre-reacted Glass Containing Dental Composites (giomers) with Improved Fluoride Release and Biocompatibility

Author

Colceriu Burtea, Loredana, primary, Prejmerean, Cristina, additional, Prodan, Doina, additional, Baldea, Ioana, additional, Vlassa, Mihaela, additional, Filip, Miuta, additional, Moldovan, Marioara, additional, (Moldovan), Madalina-Anca Lazar, additional, Antoniac, Aurora, additional, Prejmerean, Vasile, additional, and Ambrosie, Ioana, additional

Published
2019
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45. Two Adhesive Systems-effect on Adhesion to Tooth Structure

Author

Deac, Larisa Simona, primary, Earar, Kamel, additional, Colceriu Burtea, Adela Loredana, additional, Berghe, Alexandra Stefania, additional, Antoniac, Aurora, additional, Delean, Ada Gabriela, additional, Saceleanu, Vicentiu, additional, Raiciu, Anca Daniela, additional, and Hodisan, Ioana Maria, additional

Published
2019
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50. Eco-friendly, Facile and Rapid Way for Synthesis of Selenium Nanoparticles Production, structural and morphological characterisation

Author

Cavalu, Simona, primary, Kamel, Earar, additional, Laslo, Vasile, additional, Fritea, Luminita, additional, Costea, Traian, additional, Antoniac, Iulian Vasile, additional, Vasile, Eugeniu, additional, Antoniac, Aurora, additional, Semenescu, Augustin, additional, Mohan, Aurel, additional, Saceleanu, Vicentiu, additional, and Vicas, Simona, additional

Published
2018
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