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1. Safety of vaccines administration in hereditary fructose intolerance

Author

Arianna Maiorana, Antonella Sabia, Tiziana Corsetti, and Carlo Dionisi-Vici

Subjects
Hereditary fructose intolerance, Fructose, Sorbitol, Sucrose, Vaccines, Medicine
Abstract

Abstract Patients with hereditary fructose intolerance need to follow a life-long fructose dietary and drug restriction to prevent symptoms of intoxication. Concerns about vaccines administration have been manifested overtime, for the risk of a life-threatening acute intoxication. For this reason, at Ospedale Pediatrico Bambino Gesù we performed a deepen research from open sources, datasheets and Pharmaceutical Companies informations from the most common Italian and European vaccines, which are carried out in infancy and childhood. As a safe threshold of 2.4 mg/kg/dose was recently established for oral and parenteral (other than i.v.) route, the manuscript clarifies the safe administration of majority of vaccines in patients with hereditary fructose intolerance.

Published
2020
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2. Safety of vaccines administration in hereditary fructose intolerance

Author

Carlo Dionisi-Vici, Arianna Maiorana, Antonella Sabia, and Tiziana Corsetti

Subjects
0301 basic medicine, Drug, Pediatrics, medicine.medical_specialty, Sucrose, Hereditary fructose intolerance, media_common.quotation_subject, Pharmacology toxicology, lcsh:Medicine, Fructose, 030105 genetics & heredity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Humans, Medicine, Sorbitol, Pharmacology (medical), In patient, Child, Genetics (clinical), media_common, Vaccines, business.industry, lcsh:R, Acute intoxication, General Medicine, medicine.disease, Fructose Intolerance, Diet, chemistry, business, Administration (government), 030217 neurology & neurosurgery
Abstract

Patients with hereditary fructose intolerance need to follow a life-long fructose dietary and drug restriction to prevent symptoms of intoxication. Concerns about vaccines administration have been manifested overtime, for the risk of a life-threatening acute intoxication. For this reason, at Ospedale Pediatrico Bambino Gesù we performed a deepen research from open sources, datasheets and Pharmaceutical Companies informations from the most common Italian and European vaccines, which are carried out in infancy and childhood. As a safe threshold of 2.4 mg/kg/dose was recently established for oral and parenteral (other than i.v.) route, the manuscript clarifies the safe administration of majority of vaccines in patients with hereditary fructose intolerance.

Published
2020

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