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5 results on '"Antonella Capomolla"'

1. Mutual Effect Modification between Insulin Resistance and Endothelial Dysfunction in Predicting Incident Heart Failure in Hypertensives

Author

Maria Perticone, Raffaele Maio, Simona Gigliotti, Ermal Shehaj, Alfredo Francesco Toscani, Antonella Capomolla, Ginevra Fabiani, Angela Sciacqua, and Francesco Perticone

Subjects
heart failure, insulin resistance, endothelial dysfunction, hypertension, cardiovascular risk factors, Biology (General), QH301-705.5
Abstract

Insulin resistance and endothelial dysfunction are associated with heart failure (HF). Our objective was to investigate whether endothelial dysfunction and insulin resistance are independent predictors of incident HF and if a possible interaction exists between them. We enrolled 705 white never-treated hypertensives. Endothelium-dependent vasodilation was investigated by intra-arterial infusion of acetylcholine. During the follow-up [median: 117 months (range: 31–211)], we documented 223 new cases of HF (3.3 events/100 patient-years). We stratified the study population into progressors and non-progressors; progressors showed an older age and a higher prevalence of females, as well as higher mean values of baseline glucose, insulin, homeostasis model assessment (HOMA), creatinine, and high-sensitivity C-reactive protein (hs-CRP), whereas the estimated glomerular filtration rate (e-GFR) and endothelium-dependent vasodilation were lower. In the multiple Cox regression analysis, serum hs-CRP (HR = 1.362, (95% CI = 1.208–1.536), HOMA (HR = 1.293, 95% CI = 1.142–1.465), maximal acetylcholine (Ach)-stimulated forearm blood flow (FBF) (100% increment, HR = 0.807, 95% CI = 0.697–0.934), and e-GFR (10 mL/min/1.73 m2 increment, HR = 0.552, 95% CI = 0.483–0.603) maintained an independent association with incident HF. HOMA and endothelial dysfunction interact between them in a competitive manner (HR = 6.548, 95% CI = 4.034–10.629), also showing a mutual effect modification. Our findings demonstrate that both endothelial dysfunction and HOMA are independent and strong predictors of incident HF in hypertensives, these two risk factors interact between them with a competitive mechanism.

Published
2023
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2. No Coil® placement in patients undergoing left hemicolectomy and low anterior resection for colorectal cancer

Author

Michele Ammendola, Michele Ruggiero, Carlo Talarico, Riccardo Memeo, Giorgio Ammerata, Antonella Capomolla, Rosalinda Filippo, Roberto Romano, Socrate Pallio, Giuseppe Navarra, Severino Montemurro, and Giuseppe Currò

Subjects
No coil, Postoperative ileus, Anastomotic leak, Left hemicolectomy, Anterior resection, Colorectal cancer, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Colorectal cancer (CRC) is the most common tumor of the gastrointestinal tract. Anastomotic leak (AL) and prolonged postoperative ileus (PPOI) are two important complications of colorectal surgery. In this observational retrospective study, we evaluated the positive effects of transanal tube No Coil® in patients with CRC undergoing low anterior resection (LAR) and left hemicolectomy (LC). Methods Thirty-eight cases and forty controls resulted eligible for the final sample. No Coil® placement (SapiMed Spa, Alessandria, Italy) was considered an inclusion criteria for the case group. No Coil® was placed immediately after the end of surgical treatment. Results PPOI was significantly more frequent in the control group. AL was evident in 1 patient (2.6%) of cases and 3 patients (7.5%) of controls. No statistical difference was found in AL occurrence between groups. POI days and AL resulted associated with hospital stay. POI days were negatively associated with No Coil placement and positively with AL. Conclusion With our preliminary data, we suggest that No Coil® placement can be considered as a valuable procedure assisting colorectal surgery, but further studies are required to confirm and enlarge actual evidence.

Published
2020
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3. No Coil® Placement in Patients Undergoing Left Hemicolectomy and Lower Anterior Resection for Colorectal Cancer: Efficacy, Tolerability and Differences

Author

Michele Ammendola, Michele Ruggiero, Carlo Talarico, Riccardo Memeo, Giorgio Ammerata, Antonella Capomolla, Rosalinda Filippo, Roberto Romano, Socrate Pallio, Giuseppe Navarra, Severino Montemurro, and Giuseppe Currò

Subjects
nervous system, genetic structures, behavioral disciplines and activities, psychological phenomena and processes
Abstract

Background. Colorectal cancer (CRC) is the most common type of the gastrointestinal tract. Anastomotic leak (AL), is the most important complication of colorectal surgery. In this retrospective study, we evaluated efficacy and tolerability of transanal tube No Coil® in patients with CRC undergoing low anterior resection (LAR) and left hemicolectomy (LC). Methods. Thirty-eight patients operated by the same team for primary colorectal adenocarcinoma were collected, 24 LC and 14 LAR. Neither defuncioning stoma nor neoadjuvant therapy not was administered to anyone patients. No Coil® was placed immediately after the end of surgical treatment.Results. In our experience, LC was performed in 24 individuals (63%), LAR in 14 individuals (37%). AL was evident in 2,63 % of the sample; no statistical difference was found in AL occurrence between LC and LAR with only one patient in LAR group.Conclusion. With our preliminary data, we suggest that No Coil® placement can be considered as a valuable procedure assisting colorectal surgery, but further studies are required to confirm and enlarge actual evidence.

Published
2020

4. No Coil® placement in patients undergoing left hemicolectomy and low anterior resection for colorectal cancer

Author

Rosalinda Filippo, Giuseppe Currò, Antonella Capomolla, Severino Montemurro, Giuseppe Navarra, Carlo Talarico, Roberto Romano, Giorgio Ammerata, Socrate Pallio, Michele Ammendola, Riccardo Memeo, and Michele Ruggiero

Subjects
medicine.medical_specialty, Colorectal cancer, lcsh:Surgery, Anastomosis, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Surgical oncology, No coil, medicine, Humans, Anastomotic leak, In patient, Postoperative ileus, Colectomy, Retrospective Studies, Endorectal tube, Gastrointestinal tract, business.industry, Research, Retrospective cohort study, lcsh:RD1-811, Anterior resection, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, Colorectal surgery, Surgery, No coil, Postoperative ileus, Anastomotic leak, Left hemicolectomy, Anterior resection, Colorectal cancer, Endorectal tube, Oncology, Italy, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Left hemicolectomy, business, Colorectal Neoplasms
Abstract

BackgroundColorectal cancer (CRC) is the most common tumor of the gastrointestinal tract. Anastomotic leak (AL) and prolonged postoperative ileus (PPOI) are two important complications of colorectal surgery. In this observational retrospective study, we evaluated the positive effects of transanal tube No Coil®in patients with CRC undergoing low anterior resection (LAR) and left hemicolectomy (LC).MethodsThirty-eight cases and forty controls resulted eligible for the final sample. No Coil®placement (SapiMed Spa, Alessandria, Italy) was considered an inclusion criteria for the case group. No Coil®was placed immediately after the end of surgical treatment.ResultsPPOI was significantly more frequent in the control group. AL was evident in 1 patient (2.6%) of cases and 3 patients (7.5%) of controls. No statistical difference was found in AL occurrence between groups. POI days and AL resulted associated with hospital stay. POI days were negatively associated with No Coil placement and positively with AL.ConclusionWith our preliminary data, we suggest that No Coil®placement can be considered as a valuable procedure assisting colorectal surgery, but further studies are required to confirm and enlarge actual evidence.

Published
2020

5. Laparoscopic adjustable gastric banding’s multiple complications: when complications arise even after 30 years, a case report

Author

Denise Gambardella, Angelo Aldo Schicchi, Rosalinda Filippo, Manfredo Tedesco, Luigino Borrello, and Antonella Capomolla

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Stomach, Perforation (oil well), Surgery, medicine.anatomical_structure, Quality of life, Weight loss, medicine, Pouch, medicine.symptom, Laparoscopy, business, Laparoscopic adjustable gastric banding, Reduction (orthopedic surgery)
Abstract

Laparoscopic adjustable gastric banding (LAGB) is a popular bariatric surgical procedure. The introduction of laparoscopy has increased the use of this procedure, making it the most commonly performed bariatric surgery. Patients undergoing LAGB have achieved satisfactory results in terms of weight loss, a reduction in co-morbidities, and improved quality of life. Nonetheless, complications with LAGB are well documented and include migration, erosion, prolapse, infection, pouch dilation, gastric perforation, and most commonly, lack of weight loss following the failure of the procedure. This case report presents a patient with slippage and pouch dilation, erosion of the stomach, and port site problems, including infection, occurring 28 years after LAGB.

Published
2020

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