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11 results on '"Antoine-Moussiaux, T."'

1. Six-month interim analysis of ongoing immunogenicity surveillance of the mRNA-1273 vaccine in healthcare workers: A third dose is expected

Author

Tré-Hardy, Marie, Cupaiolo, Roberto, Wilmet, Alain, Antoine-Moussiaux, T., Della Vecchia, Andrea, Horeanga, Alexandra, Papleux, Emmanuelle, Vekemans, Marc, Beukinga, Ingrid, and Blairon, Laurent

Subjects
Microbiologie et protistologie [entomologie,phytoparasitolog.], Microbiologie et protistologie [parasitologie hum. et anim.], Efficacy, SARS-CoV-2, COVID-19, Pathologie maladies infectieuses, Microbiologie et protistologie [bacteriol.virolog.mycolog.], Immunogenicity, mRNA-1273 vaccine
Abstract

Objectives: Scarce data are currently available on the kinetics of antibodies after vaccination with mRNA vaccines as a whole and, with mRNA-1273, in particular. We report here an ad-interim analysis of data obtained after a 6-month follow-up in a cohort of healthcare workers (HCWs) who received the mRNA-1273 vaccine. These new data provide more insight into whether and in whom a 3rd dose could be necessary. Methods: Our study compared the anti-S antibody kinetics at 2 weeks (T1), 3 months (T3) and 6 months (T4) after the first injection, and 2 weeks after the second injection (T2). The 201 participating HCWs were stratified according to their initial serological status. The vaccine effectiveness was also assessed through a medical questionnaire. Results: We report here a marked and statistically significant antibody decrease (P < 0.05) between T3 and T4, especially in naïve vaccinees. The analysis of potential confounding factors or known risk factors for severe COVID-19 disease did not reveal any influence on the drop observed. Six-month after vaccination, only one, symptomatic, infection was reported in our cohort. Conclusions: In a supply-limited environment, our results plead for reserving the 3rd dose scheme, in the upcoming months, to seronegative individuals prior to vaccination, especially when the serological status is easily accessible., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

2. Genome-wide association study of acute renal graft rejection.

Author

Ghisdal, Lidia, Baron, Christophe, Lebranchu, Yvon, Viklicky, Ondrej, Konarikova, A, Naesens, Maarten, Kuypers, Dirk, Dinic, Miriana, Alamartine, Eric, Touchard, Guy, Antoine-Moussiaux, T., Essig, Marie, Rerolle, Jean-Philippe, Merville, Pierre, Taupin, J L, Le Meur, Yann, Grall-Jezequel, A, Glowacki, François, Noel, Christian, Legendre, Christophe, Anglicheau, D, Broeders, Emine Nilufer, Coppieters, Wouter, Docampo, E, Georges, Michel, Ajarchouh, Zineb, Massart, Annick, Racapé, Judith, Abramowicz, Daniel, Abramowicz, Marc, Ghisdal, Lidia, Baron, Christophe, Lebranchu, Yvon, Viklicky, Ondrej, Konarikova, A, Naesens, Maarten, Kuypers, Dirk, Dinic, Miriana, Alamartine, Eric, Touchard, Guy, Antoine-Moussiaux, T., Essig, Marie, Rerolle, Jean-Philippe, Merville, Pierre, Taupin, J L, Le Meur, Yann, Grall-Jezequel, A, Glowacki, François, Noel, Christian, Legendre, Christophe, Anglicheau, D, Broeders, Emine Nilufer, Coppieters, Wouter, Docampo, E, Georges, Michel, Ajarchouh, Zineb, Massart, Annick, Racapé, Judith, Abramowicz, Daniel, and Abramowicz, Marc

Abstract

Acute renal rejection is a major risk factor for chronic allograft dysfunction and long-term graft loss. We performed a genome-wide association study to detect loci associated with biopsy-proven acute T cell-mediated rejection occurring in the first year after renal transplantation. In a discovery cohort of 4127 European renal allograft recipients transplanted in eight European centers, we used a DNA pooling approach to compare 275 cases and 503 controls, on Illumina 2·5 M arrays. In an independent replication cohort of 2765 patients transplanted in two European countries, we identified 313 cases and 531 controls, in whom we genotyped individually the most significant SNPs from the discovery cohort. In the discovery cohort, we found 5 candidate loci tagged by a number of contiguous SNPs (>5) that was never reached in iterative in silico permutations of our experimental data. In the replication cohort, two loci remained significantly associated with acute rejection in both univariate and multivariate analysis. One locus encompasses PTPRO, coding for a receptor-type tyrosine kinase essential for B cell receptor signalling. The other locus involves ciliary gene CCDC67, in line with the emerging concept of a shared building design between the immune synapse and the primary cilium. This article is protected by copyright. All rights reserved., FLWOA, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

3. West Nile Virus neuroinvasive disease in an HIV positive patient 17 months after return from an endemic area

Author

Meeting of the BVIKM/SBIMC (24th October 2013: Brussels, Belgium), Antoine-Moussiaux, T., Dauby, Nicolas, Carrasco Cristina, Domingo, Van-Esbroeck, Marjan, Suin, V., De Wit, Stéphane, Libois, Agnès, Meeting of the BVIKM/SBIMC (24th October 2013: Brussels, Belgium), Antoine-Moussiaux, T., Dauby, Nicolas, Carrasco Cristina, Domingo, Van-Esbroeck, Marjan, Suin, V., De Wit, Stéphane, and Libois, Agnès

Abstract

info:eu-repo/semantics/nonPublished

Published
2013

4. Meningitis and splenic infarction due to disseminated Mycobacterium genavense infection in an HIV patient case report and review of the literature

Author

Kyrilli, Aglaia, Payen, Marie-Christine, Antoine-Moussiaux, T., De Wit, Stéphane, Clumeck, Nathan, Kyrilli, Aglaia, Payen, Marie-Christine, Antoine-Moussiaux, T., De Wit, Stéphane, and Clumeck, Nathan

Abstract

We report a case of disseminated infection with Mycobacterium genavense in a 58 year old HIV positive woman presenting with fever, diarrhea, abdominal pain and weight loss. She had a striking hepatosplenomegaly, abdominal lymphadenopathy, anaemia and thrombopenia. Direct smears and cultures of blood, stool, sputum, urine and bone marrow were negative for common and opportunistic microorganisms. Splenectomy revealed numerous acid fast bacill. Lumbar puncture also showed acid fast bacilli at direct examination. Specific PCR and 16s rRNA gene sequencing identified M. genavense. The outcome was fatal despite antimycobacterial therapy. M. genavense must be included in the differential diagnosis of fever, weight loss, lymphadenopathy and splenomegaly in immunocompromised patients. Prompt diagnosis is based on molecular biology methods. Empirical therapy, using at least three antimycobacterial agents, including clarithromycin should be introduced in case of high clinical suspicion., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2013

5. A case of severe legionellosis abscess during monoclonal antibodies treatment

Author

Congrès annuel de la Société Belge de Médecine Interne (17: 7-8 December 2012), Antoine-Moussiaux, T., Van Heurck, Roxane, Martin, Charlotte, De Wit, Stéphane, Congrès annuel de la Société Belge de Médecine Interne (17: 7-8 December 2012), Antoine-Moussiaux, T., Van Heurck, Roxane, Martin, Charlotte, and De Wit, Stéphane

Abstract

info:eu-repo/semantics/nonPublished

Published
2012

6. Four cases of XDR-Tuberculosis treated with meropem-Clavulanate

Author

Interscience Conference on Antimicrobial Agents and Chemotherapy – ICAAC (50: September 12-15, 2010: Boston, USA), Payen, Marie-Christine, Martin, Charlotte, Antoine-Moussiaux, T., De Wit, Stéphane, Clumeck, Nathan, Interscience Conference on Antimicrobial Agents and Chemotherapy – ICAAC (50: September 12-15, 2010: Boston, USA), Payen, Marie-Christine, Martin, Charlotte, Antoine-Moussiaux, T., De Wit, Stéphane, and Clumeck, Nathan

Abstract

info:eu-repo/semantics/nonPublished

Published
2010

8. Assessment 2 months after the administration of a 3rd dose mRNA: a new variant-adapted vaccine is expected.

Author

Tré-Hardy M, Cupaiolo R, Wilmet A, Antoine-Moussiaux T, Coman-Vlagea N, Della Vecchia A, Horeanga A, Papleux E, Vekemans M, Beukinga I, and Blairon L

Subjects
Adaptation, Physiological, COVID-19 Vaccines, Humans, RNA, Messenger, COVID-19
Abstract

Competing Interests: Declaration of Competing Interest The authors have no relevant competing interest to disclose in relation to this work.

Published
2022
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9. Immunogenicity of mRNA-1273 COVID vaccine after 6 months surveillance in health care workers; a third dose is necessary.

Author

Tré-Hardy M, Cupaiolo R, Wilmet A, Antoine-Moussiaux T, Della Vecchia A, Horeanga A, Papleux E, Vekemans M, Beukinga I, and Blairon L

Subjects
2019-nCoV Vaccine mRNA-1273, Antibodies, Viral, Health Personnel, Humans, Immunogenicity, Vaccine, RNA, Messenger, SARS-CoV-2, COVID-19, COVID-19 Vaccines
Abstract

Objectives: Scarce data are currently available on the kinetics of antibodies after vaccination with mRNA vaccines as a whole and, with mRNA-1273, in particular. We report here an ad-interim analysis of data obtained after a 6-month follow-up in a cohort of healthcare workers (HCWs) who received the mRNA-1273 vaccine. These new data provide more insight into whether and in whom a 3rd dose could be necessary., Methods: Our study compared the anti-S antibody kinetics at 2 weeks (T1), 3 months (T3) and 6 months (T4) after the first injection, and 2 weeks after the second injection (T2). The 201 participating HCWs were stratified according to their initial serological status. The vaccine effectiveness was also assessed through a medical questionnaire., Results: We report here a marked and statistically significant antibody decrease (P < 0.05) between T3 and T4, especially in naïve vaccinees. The analysis of potential confounding factors or known risk factors for severe COVID-19 disease did not reveal any influence on the drop observed. Six-month after vaccination, only one, symptomatic, infection was reported in our cohort., Conclusions: In a supply-limited environment, our results plead for reserving the 3rd dose scheme, in the upcoming months, to seronegative individuals prior to vaccination, especially when the serological status is easily accessible., Competing Interests: Conflicts of Competing Interest The authors have no relevant competing interest to disclose in relation to this work., (Copyright © 2021. Published by Elsevier Ltd.)

Published
2021
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10. Reactogenicity, safety and antibody response, after one and two doses of mRNA-1273 in seronegative and seropositive healthcare workers.

Author

Tré-Hardy M, Cupaiolo R, Papleux E, Wilmet A, Horeanga A, Antoine-Moussiaux T, Della Vecchia A, Beukinga I, Vekemans M, and Blairon L

Subjects
Antibodies, Viral, Health Personnel, Humans, RNA, Messenger, Antibodies, Neutralizing, Antibody Formation
Abstract

Competing Interests: Declaration of Competing Interest The authors have no relevant competing interest to disclose in relation to this work.

Published
2021
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11. Meningitis and splenic infarction due to disseminated Mycobacterium genavense infection in an HIV patient. Case report and review of the literature.

Author

Kyrilli A, Payen MC, Antoine-Moussiaux T, Dewit S, and Clumeck N

Subjects
Fatal Outcome, Female, Humans, Middle Aged, AIDS-Related Opportunistic Infections microbiology, Meningitis microbiology, Mycobacterium Infections, Nontuberculous complications, Mycobacterium Infections, Nontuberculous microbiology, Splenic Infarction microbiology
Abstract

We report a case of disseminated infection with Mycobacterium genavense in a 58 year old HIV positive woman presenting with fever, diarrhea, abdominal pain and weight loss. She had a striking hepatosplenomegaly, abdominal lymphadenopathy, anaemia and thrombopenia. Direct smears and cultures of blood, stool, sputum, urine and bone marrow were negative for common and opportunistic microorganisms. Splenectomy revealed numerous acid fast bacill. Lumbar puncture also showed acid fast bacilli at direct examination. Specific PCR and 16s rRNA gene sequencing identified M. genavense. The outcome was fatal despite antimycobacterial therapy. M. genavense must be included in the differential diagnosis of fever, weight loss, lymphadenopathy and splenomegaly in immunocompromised patients. Prompt diagnosis is based on molecular biology methods. Empirical therapy, using at least three antimycobacterial agents, including clarithromycin should be introduced in case of high clinical suspicion.

Published
2013
Full Text
View/download PDF

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