1. Glioblastoma: approach to treat elderly patients
- Author
-
Rafael Aliosha Kaliks Guendelmann, Theodora Karnakis, Suzana Maria Fleury Malheiros, Reynaldo André Brandt, Lucíola de Barros Pontes, and Eduardo Weltman
- Subjects
medicine.medical_specialty ,idoso ,medicine.medical_treatment ,Tumor resection ,lcsh:Medicine ,radioterapia ,Antineoplasic agents, alkylating/therapeutic use ,Radioterapia ,medicine ,Humans ,Intensive care medicine ,Promoter Regions, Genetic ,avaliação geriátrica ,Geriatric Assessment ,Aged ,Chemotherapy ,Temozolomide ,Radiotherapy ,Performance status ,business.industry ,Idoso ,lcsh:R ,Age Factors ,Cancer ,Geriatric assessment ,General Medicine ,DNA Methylation ,medicine.disease ,Surgery ,Avaliação geriátrica ,Radiation therapy ,Treatment Outcome ,Antineoplasic agents, alkylating ,Glioblastoma/therapy ,antineoplásicos alquilantes ,Antineoplásicos alquilantes ,business ,Glioblastoma ,medicine.drug - Abstract
Treating elderly cancer patients is a challenge for oncologists, especially considering the several therapeutic modalities in glioblastoma. Extensive tumor resection offers the best chance of local control. Adequate radiotherapy should always be given to elderly patients if they have undergone gross total resection and have maintained a good performance status. Rather than being ruled out, chemotherapy should be considered, and temozolomide is the chosen drug. A comprehensive geriatric assessment is a valuable tool to help guiding treatment decisions in elderly patients with glioblastoma. O tratamento de idosos com câncer é um desafio para a prática oncológica, especialmente no que se refere à terapêutica multimodal do glioblastoma. Nessa população, a ressecção ampla do tumor oferece a melhor chance de controle local e, naqueles pacientes que mantenham um bom performance status, a radioterapia complementar deve sempre ser levada em consideração. A quimioterapia também tem um papel no tratamento, sendo a temozolomida a droga de eleição. Frente à heterogeneidade desses pacientes, uma avaliação geriátrica ampla é um instrumento valioso no auxílio da decisão terapêutica em idosos com glioblastoma.
- Published
- 2012