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5. Feasibility of Xpert Ebola Assay in Medecins Sans Frontieres Ebola program, Guinea

Author

Van den Bergh, Rafael, Chaillet, Pascale, Sow, Mamadou Saliou, Amand, Mathieu, van Vyve, Charlotte, Jonckheere, Sylvie, Crestani, Rosa, Sprecher, Armand, Van Herp, Michel, Chua, Arlene, Piriou, Erwan, Koivogui, Lamine, and Antierens, Annick

Subjects
Ebola virus infections -- Diagnosis, Biological assay -- Innovations, Health
Abstract

As of June 28, 2015, the recent Ebola virus disease (EVD) outbreak in West Africa had claimed >11,000 lives, and 27,443 confirmed, probable, and suspected cases have been reported in [...]

Published
2016
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6. Supplement to: Evaluation of convalescent plasma for Ebola virus disease in Guinea.

Author

van Griensven, Johan, Edwards, Tansy, de Lamballerie, Xavier, Semple, Malcolm G, Gallian, Pierre, Baize, Sylvain, Horby, Peter W, Raoul, Hervé, NʼFaly, Magassouba, Antierens, Annick, Lomas, Carolyn, Faye, Ousmane, Sall, Amadou A, Fransen, Katrien, Buyze, Jozefien, Ravinetto, Raffaella, Tiberghien, Pierre, Claeys, Yves, De Crop, Maaike, Lynen, Lutgarde, Bah, Elhadj Ibrahima, Smith, Peter G, Delamou, Alexandre, De Weggheleire, Anja, and Haba, Nyankoye

Published
2016

8. Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea

Author

van Griensven, Johan, Edwards, Tansy, de Lamballerie, Xavier, Semple, Malcolm G., Gallian, Pierre, Baize, Sylvain, Horby, Peter W., Raoul, Hervé, NʼFaly, Magassouba, Antierens, Annick, Lomas, Carolyn, Faye, Ousmane, Sall, Amadou A., Fransen, Katrien, Buyze, Jozefien, Ravinetto, Raffaella, Tiberghien, Pierre, Claeys, Yves, De Crop, Maaike, Lynen, Lutgarde, Bah, Elhadj Ibrahima, Smith, Peter G., Delamou, Alexandre, De Weggheleire, Anja, and Haba, Nyankoye

Published
2016
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15. OUTBREAK OF ESBL KLEBSIELLA PNEUMONIAE IN A MSF-SUPPORTED MATERNITY IN CENTRAL AFRICAN REPUBLIC

Author

Thallinger, Monica, Ayse Acma, Antierens, Annick, Caluwaerts, An, Chaillet, Pascale, Clerck, Hilde De, Rob D 'Hondt, Kolela, Fortunat, Lambert, Vincent, Maikere, Jacob, Oluwakemi Ogundipe, Yabingui, Jean Blaise, Tremblay, Nathalie, Zuniga, Isabel, Bergh, Rafael Van Den, Herp, Michel Van, Cuesta, Julita Gil, Stefano, Letizia Di, and Msf Paediatric Days

Published
2017
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16. Outbreak of extended-spectrum beta lactamase klebsiella pneumoniae in an MSF supported maternity in Central African Republic

Author

Thallinger, Monica, primary, Acma, Ayse, additional, Antierens, Annick, additional, Caluwaerts, An, additional, Chaillet, Pascale, additional, De Clerck, Hilde, additional, Di Stefano, Letizia, additional, Kolela, Fortunat, additional, Lambert, Vincent, additional, Maikere, Jacob, additional, Ogundipe, Oluwakemi, additional, Tremblay, Nathalie, additional, Zuniga, Isabel, additional, Van den Bergh, Rafael, additional, Van Herp, Michel, additional, and Cuesta, Julita Gil, additional

Published
2018
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17. Experimental treatment of Ebola virus disease with brincidofovir

Author

Dunning, Jake, Kennedy, Stephen B., Antierens, Annick, Whitehead, John, Ciglenecki, Iza, Carson, Gail, Kanapathipillai, Rupa, Castle, Lyndsey, Howell-Jones, Rebecca, Pardinaz-Solis, Raul, Grove, Jennifer, Scott, Janet, Lang, Trudie, Olliaro, Piero, and Horby, Peter W.

Subjects
Diarrhea, RNA viruses, Adult, Male, Viral Diseases, dsDNA viruses, Organophosphonates, Gastroenterology and Hepatology, Drug research and development, Pathology and Laboratory Medicine, Ebola Hemorrhagic Fever, Microbiology, Antiviral Agents, Cytosine, Young Adult, Signs and Symptoms, Clinical trials, Adverse Reactions, Drug Therapy, Diagnostic Medicine, Medicine and Health Sciences, Humans, Microbial Pathogens, Pharmacology, Viral Hemorrhagic Fevers, Biology and life sciences, Hemorrhagic Fever Viruses, Pharmaceutics, Organisms, Hemorrhagic Fever, Ebola, Middle Aged, Tropical Diseases, Ebolavirus, Liberia, Research and analysis methods, Infectious Diseases, Treatment Outcome, Medical Microbiology, Filoviruses, Viral Pathogens, Clinical medicine, Viruses, Female, Pathogens, Ebola Virus, DNA viruses, Phase II clinical investigation, Research Article, Neglected Tropical Diseases
Abstract

Background The nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health Organisation list of agents that should be prioritised for clinical evaluation in patients with Ebola virus disease (EVD) during the West African epidemic. Methods and Findings In this single-arm phase 2 trial conducted in Liberia, patients with laboratory-confirmed EVD (two months of age or older, enrolment bodyweight ≥50 kg) received oral brincidofovir 200 mg as a loading dose on day 0, followed by 100 mg brincidofovir on days 3, 7, 10, and 14. Bodyweight-adjusted dosing was used for patients weighing

Published
2016

18. Experimental Treatment of Ebola Virus Disease with Brincidofovir

Author

Glod, John W, Dunning, Jake, Kennedy, Stephen B., Antierens, Annick, Whitehead, John, Ciglenecki, Iza, Carson, Gail, Kanapathipillai, Rupa, Castle, Lyndsey, Howell-Jones, Rebecca, Pardinaz-Solis, Raul, Grove, Jennifer, Scott, Janet, Lang, Trudie, Olliaro, Piero, and Horby, Peter W.

Subjects
Adult, Male, RAPIDE-BCV trial team, General Science & Technology, Science, Organophosphonates, Hemorrhagic Fever, Ebola, Middle Aged, Ebolavirus, Liberia, Antiviral Agents, Cytosine, Young Adult, Treatment Outcome, MD Multidisciplinary, Humans, Medicine, Female
Abstract

Background: \ud The nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health Organisation list of agents that should be prioritised for clinical evaluation in patients with Ebola virus disease (EVD) during the West African epidemic.\ud \ud Methods and Findings: \ud In this single-arm phase 2 trial conducted in Liberia, patients with laboratory-confirmed EVD (two months of age or older, enrolment bodyweight ≥50 kg) received oral brincidofovir 200 mg as a loading dose on day 0, followed by 100 mg brincidofovir on days 3, 7, 10, and 14. Bodyweight-adjusted dosing was used for patients weighing

Published
2016

19. Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: A case study in Guinea, West Africa

Author

Carazo Perez, Sara, primary, Folkesson, Elin, additional, Anglaret, Xavier, additional, Beavogui, Abdoul-Habib, additional, Berbain, Emmanuel, additional, Camara, Alseny-Modet, additional, Depoortere, Evelyn, additional, Lefevre, Annabelle, additional, Maes, Piet, additional, Malme, Kristian Nødtvedt, additional, Malvy, Jean-Marie Denis, additional, Ombelet, Sien, additional, Poelaert, Geertrui, additional, Sissoko, Daouda, additional, Tounkara, Alexis, additional, Trbovic, Pierre, additional, Piguet, Pascal, additional, and Antierens, Annick, additional

Published
2017
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20. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Author

Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael G.B., Rüsch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Béguec, Caroline, Antierens, Annick, Augustynowicz-Kopeć, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Barry, Clifton E., Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sébastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebæk, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Branislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, Vukovic, Dragana, Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael G.B., Rüsch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Béguec, Caroline, Antierens, Annick, Augustynowicz-Kopeć, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Barry, Clifton E., Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sébastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebæk, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Branislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, and Vukovic, Dragana

Abstract

Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.

Published
2015

21. Low Incidence of Renal Dysfunction among HIV-Infected Patients on a Tenofovir-Based First Line Antiretroviral Treatment Regimen in Myanmar

Author

Kyaw, Nang Thu Thu, primary, Harries, Anthony D., additional, Chinnakali, Palanivel, additional, Antierens, Annick, additional, Soe, Kyi Pyar, additional, Woodman, Mike, additional, Das, Mrinalini, additional, Shetty, Sharmila, additional, Zuu, Moe Khine Lwin, additional, Htwe, Pyae Sone, additional, and Fernandez, Marcelo, additional

Published
2015
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24. Factors Associated with Virological Failure and Suppression after Enhanced Adherence Counselling, in Children, Adolescents and Adults on Antiretroviral Therapy for HIV in Swaziland

Author

Jobanputra, Kiran, primary, Parker, Lucy Anne, additional, Azih, Charles, additional, Okello, Velephi, additional, Maphalala, Gugu, additional, Kershberger, Bernard, additional, Khogali, Mohammed, additional, Lujan, Johnny, additional, Antierens, Annick, additional, Teck, Roger, additional, Ellman, Tom, additional, Kosgei, Rose, additional, and Reid, Tony, additional

Published
2015
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25. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Author

Merker, Matthias, primary, Blin, Camille, additional, Mona, Stefano, additional, Duforet-Frebourg, Nicolas, additional, Lecher, Sophie, additional, Willery, Eve, additional, Blum, Michael G B, additional, Rüsch-Gerdes, Sabine, additional, Mokrousov, Igor, additional, Aleksic, Eman, additional, Allix-Béguec, Caroline, additional, Antierens, Annick, additional, Augustynowicz-Kopeć, Ewa, additional, Ballif, Marie, additional, Barletta, Francesca, additional, Beck, Hans Peter, additional, Barry, Clifton E, additional, Bonnet, Maryline, additional, Borroni, Emanuele, additional, Campos-Herrero, Isolina, additional, Cirillo, Daniela, additional, Cox, Helen, additional, Crowe, Suzanne, additional, Crudu, Valeriu, additional, Diel, Roland, additional, Drobniewski, Francis, additional, Fauville-Dufaux, Maryse, additional, Gagneux, Sébastien, additional, Ghebremichael, Solomon, additional, Hanekom, Madeleine, additional, Hoffner, Sven, additional, Jiao, Wei-wei, additional, Kalon, Stobdan, additional, Kohl, Thomas A, additional, Kontsevaya, Irina, additional, Lillebæk, Troels, additional, Maeda, Shinji, additional, Nikolayevskyy, Vladyslav, additional, Rasmussen, Michael, additional, Rastogi, Nalin, additional, Samper, Sofia, additional, Sanchez-Padilla, Elisabeth, additional, Savic, Branislava, additional, Shamputa, Isdore Chola, additional, Shen, Adong, additional, Sng, Li-Hwei, additional, Stakenas, Petras, additional, Toit, Kadri, additional, Varaine, Francis, additional, Vukovic, Dragana, additional, Wahl, Céline, additional, Warren, Robin, additional, Supply, Philip, additional, Niemann, Stefan, additional, and Wirth, Thierry, additional

Published
2015
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26. Impact and Programmatic Implications of Routine Viral Load Monitoring in Swaziland

Author

Jobanputra, Kiran, primary, Parker, Lucy Anne, additional, Azih, Charles, additional, Okello, Velephi, additional, Maphalala, Gugu, additional, Jouquet, Guillaume, additional, Kerschberger, Bernhard, additional, Mekeidje, Calorine, additional, Cyr, Joanne, additional, Mafikudze, Arnold, additional, Han, Win, additional, Lujan, Johnny, additional, Teck, Roger, additional, Antierens, Annick, additional, van Griensven, Johan, additional, and Reid, Tony, additional

Published
2014
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28. Impact of Human Immunodeficiency Virus on the Severity of Buruli Ulcer Disease: Results of a Retrospective Study in Cameroon

Author

Christinet, Vanessa, primary, Comte, Eric, additional, Ciaffi, Laura, additional, Odermatt, Peter, additional, Serafini, Micaela, additional, Antierens, Annick, additional, Rossel, Ludovic, additional, Nomo, Alain-Bertrand, additional, Nkemenang, Patrick, additional, Tsoungui, Akoa, additional, Delhumeau, Cecile, additional, and Calmy, Alexandra, additional

Published
2014
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32. ‘I can change my life’: perceptions and experiences of people who use drugs engaging in medically assisted therapy in Kiambu County, Kenya.

Author

Burtscher, Doris, Riitho, Winnie, Kariuki, Morris, Thiong’o, Angela, Ayuaya, Tolbert, Kerschberger, Bernhard, Atte, Edi, Verschuere, Jesse, Tampellini, Livia, Pellecchia, Umberto, O’Connell, Lucy, Ellman, Tom, Levine, Barrett, Ngethe, Janet, and Antierens, Annick

Abstract

AbstractIntroductionMethodsResultsConclusionThe Médecins Sans Frontières (MSF) Kiambu People Who Use Drugs (PWUD) project, which started in September 2019, had enrolled 590 PWUD in its Medically Assisted Therapy (MAT) program by April 2022. This project provides a one-stop-shop model, offering a comprehensive range of medical and psychosocial services. This study aimed to explore how PWUD navigate from heroin use to MAT enrolment.The study involved individual, paired and group interviews conducted between August and October 2022. Purposive sampling was applied. Interviews were recorded, transcribed, coded with NVivo and analysed using reflexive thematic analysis. Methodological triangulation enhanced interpretation.PWUD faced various challenges to engage in the MAT program. Replacing heroin with MAT, the ‘medicine,’ was insufficient to ensure meaningful recovery. Engaging in MAT required personal motivation to exit the hotspots that their lives revolve around. Main barriers were coping with changed lifestyles and behavioural patterns, and the need to develop new perspectives on dealing with ‘idleness.’The study revealed the complex realities PWUD are confronted with when trying to engage in MAT. MAT programs need to address medical, psychosocial, employment and other structural factors while supporting people to restore their broken social conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage (vol 47, pg 242, 2015)

Author

Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael, Ruesch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Beguec, Caroline, Antierens, Annick, Augustynowicz-Kopec, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Clifton E Barry, Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sebastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei-Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebeak, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Ranislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li-Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, Vukovic, Dragana, Wahl, Celine, Warren, Robin, Supply, Philip, Niemann, Stefan, and Wirth, Thierry

34. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Author

Blum, Michael G B, Blin, Camille, Drobniewski, Francis, Wirth, Thierry, Stakenas, Petras, Allix-Béguec, Caroline, Barletta, Francesca, Sanchez-Padilla, Elisabeth, Warren, Robin, Vukovic, Dragana, Toit, Kadri, Augustynowicz-Kopeć, Ewa, Borroni, Emanuele, Varaine, Francis, Barry, Clifton E, Fauville-Dufaux, Maryse, Gagneux, Sébastien, Mokrousov, Igor, Cox, Helen, Samper, Sofia, Duforet-Frebourg, Nicolas, Kohl, Thomas A, Maeda, Shinji, Bonnet, Maryline, Aleksic, Eman, Wahl, Céline, Hanekom, Madeleine, Rüsch-Gerdes, Sabine, Hoffner, Sven, Campos-Herrero, Isolina, Ballif, Marie, Jiao, Wei-Wei, Crowe, Suzanne, Rastogi, Nalin, Ghebremichael, Solomon, Lillebæk, Troels, Sng, Li-Hwei, Cirillo, Daniela, Kalon, Stobdan, Kontsevaya, Irina, Antierens, Annick, Rasmussen, Michael, Nikolayevskyy, Vladyslav, Supply, Philip, Crudu, Valeriu, Diel, Roland, Savic, Branislava, Merker, Matthias, Niemann, Stefan, Beck, Hans Peter, Lecher, Sophie, Shen, Adong, Shamputa, Isdore Chola, Willery, Eve, and Mona, Stefano

Subjects
610 Medicine & health, 360 Social problems & social services, 3. Good health
Abstract

Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.

35. Impact and programmatic implications of routine viral load monitoring in Swaziland.

Author

Jobanputra K, Parker LA, Azih C, Okello V, Maphalala G, Jouquet G, Kerschberger B, Mekeidje C, Cyr J, Mafikudze A, Han W, Lujan J, Teck R, Antierens A, van Griensven J, and Reid T

Subjects
Adolescent, Adult, CD4 Lymphocyte Count, Child, Cohort Studies, Cost-Benefit Analysis, Counseling, Eswatini, Female, HIV Infections economics, Humans, Male, Medication Adherence, Retrospective Studies, Statistics, Nonparametric, Viral Load, Young Adult, Anti-HIV Agents administration & dosage, HIV Infections drug therapy, HIV Infections virology, HIV-1 isolation & purification
Abstract

Objective: To assess the programmatic quality (coverage of testing, counseling, and retesting), cost, and outcomes (viral suppression, treatment decisions) of routine viral load (VL) monitoring in Swaziland., Design: Retrospective cohort study of patients undergoing routine VL monitoring in Swaziland (October 1, 2012 to March 31, 2013)., Results: Of 5563 patients eligible for routine VL testing monitoring in the period of study, an estimated 4767 patients (86%) underwent testing that year. Of 288 patients with detectable VL, 210 (73%) underwent enhanced adherence counseling and 202 (70%) had a follow-up VL within 6 months. Testing coverage was slightly lower in children, but coverage of retesting was similar between and age groups and sexes. Of those with a follow-up test, 126 (62%) showed viral suppression. The remaining 78 patients had World Health Organization-defined virologic failure; 41 (53%) were referred by the doctor for more adherence counseling, and 13 (15%) were changed to second-line therapy, equating to an estimated rate of 1.2 switches per 100 patient-years. Twenty-four patients (32%) were transferred out, lost to follow-up, or not reviewed by doctor. The "fully loaded" cost of VL monitoring was $35 per patient-year., Conclusions: Achieving good quality VL monitoring is feasible and affordable in resource-limited settings, although close supervision is needed to ensure good coverage of testing and counseling. The low rate of switch to second-line therapy in patients with World Health Organization-defined virologic failure seems to reflect clinician suspicion of ongoing adherence problems. In our study, the main impact of routine VL monitoring was reinforcing adherence rather than increasing use of second-line therapy.

Published
2014
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