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1. Clinical evaluation of QT/QTc prolongation and proarrhythmic potential for nonantiarrhythmic drugs: the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use E14 guideline

Author

Darpo, Borje, Nebout, Thierry, and Sager, Philip T.

Subjects
Anti-arrhythmia drugs -- Complications and side effects -- Evaluation -- Dosage and administration -- Standards, Arrhythmia -- Physiological aspects -- Drug therapy -- Risk factors -- Causes of -- Complications and side effects, Drugs -- Product/Service Evaluations, Health, Drug therapy, Evaluation, Standards, Complications and side effects, Physiological aspects, Risk factors, Dosage and administration, Causes of
Abstract

Proarrhythmias due to drug-induced QT prolongation are the second most common cause for drug withdrawal and have caused increasing concern. Two new International Conference on Harmonization of Technical Requirements for [...]

Published
2006

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