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Background:\ud Recurrence is common after neoadjuvant chemotherapy and radical treatment for muscle-invasive bladder cancer. We investigated the effect of adding nintedanib to neoadjuvant chemotherapy on response and survival in muscle-invasive bladder cancer.\ud \ud Methods:\ud NEOBLADE was a parallel-arm, double-blind, randomised, placebo-controlled, phase 2 trial of neoadjuvant gemcitabine and cisplatin chemotherapy with nintedanib or placebo in locally advanced muscle-invasive bladder cancer. Patients aged 18 years or older, with an Eastern Cooperative Oncology Group performance status of 0–1, were recruited from 15 hospitals in the UK. Patients were randomly assigned (1:1) to nintedanib or placebo using permuted blocks with random block sizes of two or four, stratified by centre and glomerular filtration rate. Treatments were allocated using an interactive web-based system, and patients and investigators were masked to treatment allocation throughout the study. Patients received oral nintedanib (150 mg or 200 mg twice daily for 12 weeks) or placebo, in addition to usual neoadjuvant chemotherapy with intravenous gemcitabine 1000 mg/m2 on days 1 and 8 and intravenous cisplatin 70 mg/m2 on day 1 of a 3-weekly cycle. The primary endpoint was pathological complete response rate, assessed at cystectomy or at day 8 of cyclde 3 (plus or minus 7 days) if cystectomy did not occur. Primary analyses were done in the intention-to-treat population. The trial is registered with EudraCT, 2012-004895-01, and ISRCTN, 56349930, and has completed planned recruitment.\ud \ud Findings:\ud Between Dec 4, 2014, and Sept 3, 2018, 120 patients were recruited and were randomly allocated to receive nintedanib (n=57) or placebo (n=63). The median follow-up for the study was 33·5 months (IQR 14·0–44·0). Pathological complete response in the intention-to-treat population was reached in 21 (37%) of 57 patients in the nintedanib group and 20 (32%) of 63 in the placebo group (odds ratio [OR] 1·25, 70% CI 0·84–1·87; p=0·28). Grade 3 or worse toxicities were observed in 53 (93%) of 57 participants who received nintedanib and 50 (79%) of 63 patients in the placebo group (OR 1·65, 95% CI 0·74–3·65; p=0·24). The most common grade 3 or worse adverse events were thromboembolic events (17 [30%] of 57 patients in the nintedanib group vs 13 [21%] of 63 patients in the placebo group [OR 1·63, 95% CI 0·71–3·76; p=0·29]) and decreased neutrophil count (22 [39%] in the nintedanib group vs seven [11%] in the placebo group [5·03, 1·95–13·00; p=0·0006]). 45 treatment-related serious adverse events occurred in the nintedanib group and 43 occurred in the placebo group. One treatment-related death occurred in the placebo group, which was due to myocardial infarction.\ud \ud Interpretation:\ud The addition of nintedanib to chemotherapy was safe but did not improve the rate of pathological complete response in muscle-invasive bladder cancer.\ud \ud Funding:\ud Boehringer Ingelheim.

In this comprehensive and clear introduction to contemporary social theory, Anthony Elliott and Charles Lemert explore the major theoretical traditions from the Frankfurt School to the digital revolution and beyond. Fully revised and updated, this second edition has been expanded to consider the most recent developments in social theory, including a new chapter on the digital revolution and the increasingly significant impact of technological developments (such as artificial intelligence, machine learning and robotics) on society, culture and politics. Introduction to Contemporary Social Theory provides the reader with a superb overview of key developments in social theory, including the Frankfurt School, American pragmatism, structuralism, post-structuralism, feminism, globalization and world-systems theory. In doing so, the textbook explores the ideas of a wide range of social theorists, including Theodor Adorno, Herbert Marcuse, Talcott Parsons, Erving Goffman, Harold Garfinkel, Michel Foucault, Jacques Lacan, Jacques Derrida, C. Wright Mills, Anthony Giddens, Pierre Bourdieu, Julia Kristeva, Jürgen Habermas, Judith Butler, Slavoj Žižek, Manuel Castells, Cornel West, Immanuel Wallerstein and Zygmunt Bauman. This textbook provides stylish exposition with powerful social critique and original insights. It will be indispensable to students and academics alike.

The Routledge Social Science Handbook of AI is a landmark volume providing students and teachers with a comprehensive and accessible guide to the major topics and trends of research in the social sciences of artificial intelligence (AI), as well as surveying how the digital revolution - from supercomputers and social media to advanced automation and robotics - is transforming society, culture, politics and economy. The Handbook provides representative coverage of the full range of social science engagements with the AI revolution, from employment and jobs to education and new digital skills to automated technologies of military warfare and the future of ethics. The reference work is introduced by editor Anthony Elliott, who addresses the question of relationship of social sciences to artificial intelligence, and who surveys various convergences and divergences between contemporary social theory and the digital revolution. The Handbook is exceptionally wide-ranging in span, covering topics all the way from AI technologies in everyday life to single-purpose robots throughout home and work life, and from the mainstreaming of human-machine interfaces to the latest advances in AI, such as the ability to mimic (and improve on) many aspects of human brain function. A unique integration of social science on the one hand and new technologies of artificial intelligence on the other, this Handbook offers readers new ways of understanding the rise of AI and its associated global transformations. Written in a clear and direct style, the Handbook will appeal to a wide undergraduate audience.

Now in its third edition, Anthony Elliott’s comprehensive, stylish and accessible introduction continues to be the indispensable guide to social theory. Fully revised and updated, the book examines the major theoretical traditions from the Frankfurt School to posthumanism, and from feminism and post-structuralism to globalization theory and beyond. Classical debates in social theory are given careful appraisal, as are the major contemporary theorists – including Jurgen Habermas, Judith Butler, Anthony Giddens, Pierre Bourdieu, Julia Kristeva, Slavoj Žižek, Manuel Castells, Ulrich Beck, Zygmunt Bauman, Shoshana Zuboff and Bernard Stiegler. This edition includes a new chapter on the digital revolution, with consideration of how digital technologies in general and artificial intelligence in particular are reshaping societies. Like its predecessors, the third edition of Contemporary Social Theory combines stylish exposition with reflective social critique and original insights. This volume will prove a superb textbook with which to navigate the twists and turns of contemporary social theory as taught in the disciplines of sociology, politics, cultural and media studies and many more.

Ours is the era of “reinvention”. From psychotherapy to life coaching, from self-help manuals to cosmetic surgery and from corporate rebranding to urban redesign: the art of reinvention is inextricably interwoven with the lure of the next frontier, the breakthrough to the next boundary –especially boundaries of the self. In this new, updated edition of this remarkable book, Anthony Elliott examines “reinvention” as a key buzzword of our times. Through a wide-ranging and impassioned assessment, Elliott unmasks the ever-increasing globalization of reinvention – from reinvention gurus to business reinvention, from personal makeovers to corporate rebrandings. In doing so, he undertakes a serious if often amusing consideration of contemporary reinvention practices, including super-fast weight-loss diets, celebrity makeovers, body augmentations, speed dating, online relationship therapies, organizational restructurings, business downsizings and many more. The second edition of Reinvention includes a new chapter on the digital revolution and artificial intelligence, which situates reinvention within the context of technological automation. There is also a discussion of how the Covid-19 global pandemic has impacted today’s cultures of reinvention. In addition, there is a new concluding chapter in which the author develops further his theoretical account of the nature of reinvention societies. This absorbing book will continue to be the ideal introduction to reinvention for students and general readers alike. Reinvention offers a provocative and radical reflection on an issue (sometimes treated as trivial in the public sphere) that is increasingly politically urgent in terms of its personal, social and environmental consequences.