Search

Your search keyword '"Anthony, E.J."' showing total 514 results
Start Over Author "Anthony, E.J."
514 results on '"Anthony, E.J."'

3. Peanut Can Be Used as a Reference Allergen for Hazard Characterization in Food Allergen Risk Management: A Rapid Evidence Assessment and Meta-Analysis

Author

Turner, Paul J., Patel, Nandinee, Ballmer-Weber, Barbara K., Baumert, Joe L., Blom, W. Marty, Brooke-Taylor, Simon, Brough, Helen, Campbell, Dianne E., Chen, Hongbing, Chinthrajah, R. Sharon, Crevel, René W.R., Dubois, Anthony E.J., Ebisawa, Motohiro, Elizur, Arnon, Gerdts, Jennifer D., Gowland, M. Hazel, Houben, Geert F., Hourihane, Jonathan O.B., Knulst, André C., La Vieille, Sébastien, López, María Cristina, Mills, E.N. Clare, Polenta, Gustavo A., Purington, Natasha, Said, Maria, Sampson, Hugh A., Schnadt, Sabine, Södergren, Eva, Taylor, Stephen L., and Remington, Benjamin C.

Published
2022
Full Text
View/download PDF

6. Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens

Author

Westerhout, Joost, Baumert, Joseph L., Blom, W. Marty, Allen, Katrina J., Ballmer-Weber, Barbara, Crevel, René W.R., Dubois, Anthony E.J., Fernández-Rivas, Montserrat, Greenhawt, Matthew J., Hourihane, Jonathan O'B., Koplin, Jennifer J., Kruizinga, Astrid G., Le, Thuy-My, Sampson, Hugh A., Shreffler, Wayne G., Turner, Paul J., Taylor, Steve L., Houben, Geert F., and Remington, Benjamin C.

Published
2019
Full Text
View/download PDF

9. Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Author

Asai, Yuka, Eslami, Aida, van Ginkel, C. Dorien, Akhabir, Loubna, Wan, Ming, Ellis, George, Ben-Shoshan, Moshe, Martino, David, Ferreira, Manuel A., Allen, Katrina, Mazer, Bruce, de Groot, Hans, de Jong, Nicolette W., Gerth van Wijk, Roy N., Dubois, Anthony E.J., Chin, Rick, Cheuk, Stephen, Hoffman, Joshua, Jorgensen, Eric, Witte, John S., Melles, Ronald B., Hong, Xiumei, Wang, Xiaobin, Hui, Jennie, Musk, Arthur W. (Bill), Hunter, Michael, James, Alan L., Koppelman, Gerard H., Sandford, Andrew J., Clarke, Ann E., and Daley, Denise

Published
2018
Full Text
View/download PDF

31. Health-related quality of life in food-allergic adults from eight European countries

Author

Goossens, Nicole J., Flokstra-de Blok, Bertine M.J., van der Meulen, Gerbrich N., Arnlind, Marianne H., Asero, Ricardo, Barreales, Laura, Burney, Peter, Cerecedo, Imnaculada, Clausen, Michael, Fernandéz-Rivas, Monteserrat, Frewer, Lynn, de la Hoz Caballer, Belén, Jansson, Sven-Arne, Jedrzejczak-Czechowicz, Monica, Knulst, André C., Kowalski, Marek L., Papadopoulos, Nikos G., Purohit, Ashok, Rokicka, Ewa, Starosta, Pawel, Vásquez-Cortés, Sonia, Duiverman, Eric J., and Dubois, Anthony E.J.

Published
2014
Full Text
View/download PDF

44. The direct and indirect costs associated with food hypersensitivity in households: A study in the Netherlands, Poland, and Spain

Author

Jantine Voordouw, Gerrit Antonides, Margaret Fox, Inma Cerecedo, Javier Zamora, Belen de la Hoz Caballer, Ewa Rokicka, Judith R. Cornelisse-Vermaat, Maciej Jewczak, Pawel Starosta, Marek Kowalski, Monika Jędrzejczak-Czechowicz, Sonia Vázquez-Cortes, Sara Cano-Escudero, Bertine M.J. Flokstra-De Blok, Anthony E.J. Dubois, Miranda Mugford, and Lynn J. Frewer

Subjects
food hypersensitivity, households, the Netherlands, Poland, Spain, Agriculture, Regional planning, HT390-395
Abstract

Background: Recent studies show that food hypersensitivity, such as food allergy or food intolerance, has the potential to affect direct, indirect and intangible economic costs experienced by individuals and their families. This research assesses the direct and indirect economic costs of food hypersensitivity at the household level in the Netherlands, Poland, and Spain. Methods: A self-administered postal survey was conducted (n=1558). Respondents with food hypersensitivity were clinically diagnosed cases recruited through clinical centres in Poland and Spain. In the Netherlands, food hypersensitivity cases were recruited through hospitals, patient organisations and advertisements. The controls formed the baseline sample and were obtained from households in which none of the members had food hypersensitivity. The monetary value of indirect costs, forgone time, was calculated using the opportunity cost method. The indirect and direct costs were expressed in purchasing power parity. Analysis of co-variance on the cost items was used to test the within-country differences between respondents with food hypersensitivity and respondents without food hypersensitivity, as well as across the three countries. Results: The average total direct and indirect costs across all countries for families with food hypersensitive family members are not higher than for households without food hypersensitive members. However, the intangible costs for food hypersensitive individuals appear to be higher than for individuals in the control group. Conclusions: These results do not support the hypothesis that all food allergies incur high costs to the individual. However, being hypersensitive to foods may have a negative impact on quality of life compared to people who are not food hypersensitive.

Published
2016
Full Text
View/download PDF

45. Peanut Can Be Used as a Reference Allergen for Hazard Characterization in Food Allergen Risk Management: A Rapid Evidence Assessment and Meta-Analysis

Author

MS Dermatologie/Allergologie, Infection & Immunity, Turner, Paul J., Patel, Nandinee, Ballmer-Weber, Barbara K., Baumert, Joe L., Blom, W. Marty, Brooke-Taylor, Simon, Brough, Helen, Campbell, Dianne E., Chen, Hongbing, Chinthrajah, R. Sharon, Crevel, René W.R., Dubois, Anthony E.J., Ebisawa, Motohiro, Elizur, Arnon, Gerdts, Jennifer D., Gowland, M. Hazel, Houben, Geert F., Hourihane, Jonathan O.B., Knulst, André C., La Vieille, Sébastien, López, María Cristina, Mills, E. N.Clare, Polenta, Gustavo A., Purington, Natasha, Said, Maria, Sampson, Hugh A., Schnadt, Sabine, Södergren, Eva, Taylor, Stephen L., Remington, Benjamin C., MS Dermatologie/Allergologie, Infection & Immunity, Turner, Paul J., Patel, Nandinee, Ballmer-Weber, Barbara K., Baumert, Joe L., Blom, W. Marty, Brooke-Taylor, Simon, Brough, Helen, Campbell, Dianne E., Chen, Hongbing, Chinthrajah, R. Sharon, Crevel, René W.R., Dubois, Anthony E.J., Ebisawa, Motohiro, Elizur, Arnon, Gerdts, Jennifer D., Gowland, M. Hazel, Houben, Geert F., Hourihane, Jonathan O.B., Knulst, André C., La Vieille, Sébastien, López, María Cristina, Mills, E. N.Clare, Polenta, Gustavo A., Purington, Natasha, Said, Maria, Sampson, Hugh A., Schnadt, Sabine, Södergren, Eva, Taylor, Stephen L., and Remington, Benjamin C.

Published
2022

47. Peanut Can Be Used as a Reference Allergen for Hazard Characterization in Food Allergen Risk Management: A Rapid Evidence Assessment and Meta-Analysis

Author

M. Hazel Gowland, Natasha Purington, Nandinee Patel, Dianne E. Campbell, Arnon Elizur, María Cristina López, Sebastien La Vieille, Hugh A. Sampson, Anthony E.J. Dubois, Eva Södergren, Motohiro Ebisawa, Benjamin C. Remington, Sabine Schnadt, E. N. Clare Mills, Barbara Ballmer-Weber, Helen A. Brough, R. Sharon Chinthrajah, Geert F. Houben, André C. Knulst, W. Marty Blom, Gustavo Alberto Polenta, Paul Turner, Jonathan Hourihane, Stephen L Taylor, Simon Brooke-Taylor, Jennifer Gerdts, Maria Said, René W.R. Crevel, Joseph L. Baumert, Hongbing Chen, Groningen Research Institute for Asthma and COPD (GRIAC), Medical Research Council (MRC), National Institute for Health Research, University of Zurich, and Turner, Paul J

Subjects
ORAL TOLERANCE INDUCTION, CLINICAL REACTIVITY, Arachis, IGE ANTIBODIES, PFAS, Pollen food allergy syndrome, WHEAT ALLERGY, medicine.disease_cause, DOUBLE-BLIND, Allergen, Dosis de Referencia, Food Labeling, immune system diseases, Alérgenos, COWS MILK ALLERGY, Immunology and Allergy, Risk management, Randomized Controlled Trials as Topic, ED, Eliciting dose, Threshold, 10177 Dermatology Clinic, Hazard, humanities, Eliciting Dose, Dosis Provocadora, Meta-analysis, CROSS-REACTIVITY, ED01, Amount of allergen expected to cause objective symptoms in 1% of the population with that allergy, 2723 Immunology and Allergy, ED05, Amount of allergen expected to cause objective symptoms in 5% of the population with that allergy, Alergia Alimentaria, THRESHOLD DOSE DISTRIBUTIONS, Eliciting dose, Food Hypersensitivity, Precautionary allergen labeling, Food Allergies, 610 Medicine & health, Legislation, Cacahuete, Maní, PAL, Precautionary allergen labeling, Risk Assessment, WHO, World Health Organization, Reference Dose, Food allergy, Environmental health, FC, Food challenge, medicine, Humans, Precautionary Allergen Labeling, Review and Feature Article, Reacciones Anafilácticas, Anaphylaxis, HENS EGG, EIA, Exercise-induced anaphylaxis, Reference dose, CI, Confidence interval, business.industry, CHALLENGE-PROVEN, Evidence-based medicine, Allergens, medicine.disease, Etiquetado Preventivo de Alérgenos, Umbral, Groundnuts, Metanálisis, respiratory tract diseases, Peanut, FAO, Food and Agriculture Organization, business, DBPCFC, Double-blind, placebo-controlled food challenge, Anaphylactic Reactions, Meta-Analysis
Abstract

Regional and national legislation mandates the disclosure of “priority” allergens when present as an ingredient in foods, but this does not extend to the unintended presence of allergens due to shared production facilities. This has resulted in a proliferation of precautionary allergen (“may contain”) labels (PAL) that are frequently ignored by food-allergic consumers. Attempts have been made to improve allergen risk management to better inform the use of PAL, but a lack of consensus has led to variety of regulatory approaches and nonuniformity in the use of PAL by food businesses. One potential solution would be to establish internationally agreed “reference doses,” below which no PAL would be needed. However, if reference doses are to be used to inform the need for PAL, then it is essential to characterize the hazard associated with these low-level exposures. For peanut, there are now published data relating to over 3000 double-blind, placebo-controlled challenges in allergic individuals, but a similar level of evidence is lacking for other priority allergens. We present the results of a rapid evidence assessment and meta-analysis for the risk of anaphylaxis to a low-level allergen exposure for priority allergens. On the basis of this analysis, we propose that peanut can and should be considered an exemplar allergen for the hazard characterization at a low-level allergen exposure. Resumen: La legislación regional y nacional exige la divulgación de alérgenos "prioritarios" cuando están presentes como ingrediente en los alimentos, pero esto no se extiende a la presencia involuntaria de alérgenos debido a instalaciones de producción compartidas. Esto ha dado lugar a una proliferación de etiquetas de precaución para alérgenos ("pueden contener") (PAL) que los consumidores alérgicos a los alimentos suelen ignorar. Se han hecho intentos para mejorar la gestión del riesgo de alérgenos para informar mejor el uso de PAL, pero la falta de consenso ha llevado a una variedad de enfoques regulatorios y a la falta de uniformidad en el uso de PAL por parte de las empresas alimentarias. Una posible solución sería establecer “dosis de referencia” acordadas internacionalmente, por debajo de las cuales no se necesitaría PAL. Sin embargo, si se van a utilizar dosis de referencia para informar la necesidad de PAL, entonces es esencial caracterizar el peligro asociado con estas exposiciones de bajo nivel. Para el maní, ahora hay datos publicados relacionados con más de 3000 desafíos doble ciego controlados por placebo en individuos alérgicos, pero falta un nivel similar de evidencia para otros alérgenos prioritarios. Presentamos los resultados de una evaluación rápida de la evidencia y un metanálisis del riesgo deanafilaxia a una exposición a alérgenos de bajo nivel para alérgenos prioritarios. Sobre la base de este análisis, proponemos que el cacahuete puede y debe considerarse un alérgeno ejemplar para la caracterización del peligro en una exposición a un alérgeno de bajo nivel. Instituto de Investigación de Tecnología de Alimentos Fil: Turner, Paul J. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Patel, Nandinee. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Ballmer-Weber, Barbara K. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Ballmer-Weber, Barbara K. Clínica de Dermatología y Alergología. Kantonsspital; Suiza. Fil: Baumert, Joe L. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Blom, W. Marty. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Brooke-Taylor, Simon. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Brough, Helen. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Brough, Helen. King's College London. Departamento de Alergia Pediátrica; Reino Unido. Fil: Campbell, Dianne E. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Campbell, Dianne E. Tecnologías DBV. Montrouge; Francia. Fil: Chen, Hongbing. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Chinthrajah, R. Sharon. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Crevel, René W.R. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Dubois, Anthony E.J. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Ebisawa, Motohiro. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Elizur, Arnon. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Elizur, Arnon. Universidad de Tel Aviv. Facultad de Medicina Sackler. Departamento de Pediatría; Israel. Fil: Gerdts, Jennifer D. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Gowland, M. Hazel. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Houben, Geert F. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Hourihane, Jonathan O.B. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Knulst, André C. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: La Vieille, Sébastien. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: López, María Cristina. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Mills, E.N. Clare. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Polenta, Gustavo Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Tecnología de Alimentos; Argentina. Fil: Polenta, Gustavo Alberto. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Purington, Natasha. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Said, María. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Sampson, Hugh A. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Sampson, Hugh A. Escuela de Medicina Icahn. División de Alergia e Inmunología Pediátricasen. Nueva York. Estados Unidos de América. Fil: Schnadt, Sabine. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Södergren, Eva. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Södergren, Eva. ThermoFisher Scientific; Suecia. Fil: Taylor, Stephen L. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Remington, Benjamin C. Imperial College London. Instituto Nacional del Corazón y los Pulmones; Reino Unido. Fil: Remington, Benjamin C. Grupo BV. Consultoría Remington; Holanda.

Published
2022

48. Food allergy: Stakeholder perspectives on acceptable risk

Author

Madsen, Charlotte B., Crevel, René, Chan, Chun-Han, Dubois, Anthony E.J., DunnGalvin, Audrey, Flokstra-de Blok, Bertine M.J., Gowland, M. Hazel, Hattersley, Sue, Hourihane, Jonathan O’B, Nørhede, Pia, Pfaff, Sylvia, Rowe, Gene, Schnadt, Sabine, and Vlieg-Boerstra, Berber J.

Published
2010
Full Text
View/download PDF

50. Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens

Author

Benjamin C. Remington, Joost Westerhout, Jennifer J. Koplin, Thuy My Le, Hugh A. Sampson, W. Marty Blom, Wayne G. Shreffler, Matthew Greenhawt, René W.R. Crevel, Geert F. Houben, Montserrat Fernandez-Rivas, Jonathan O'b Hourihane, Katrina J. Allen, Anthony E.J. Dubois, Joseph L. Baumert, Barbara Ballmer-Weber, Astrid G. Kruizinga, Steve L. Taylor, Paul Turner, University of Zurich, Blom, W Marty, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
Male, no observed adverse effect level-lowest observed adverse effect level derivation, double-blind, placebo-controlled food challenge, Administration, Oral, CHILDREN, food challenge, placebo-controlled food challenge, DOUBLE-BLIND, threshold, eliciting dose, Immunology and Allergy, Decision-making, Risk management, education.field_of_study, Biological Variation, Individual, 10177 Dermatology Clinic, risk assessment, Child, Preschool, no observed adverse effect level–lowest observed adverse effect level derivation, 2723 Immunology and Allergy, Female, Risk assessment, Food Hypersensitivity, medicine.medical_specialty, Resource (biology), EUROPE, Maximum Tolerated Dose, Clinical Decision-Making, Population, Immunology, 610 Medicine & health, PEANUT, DIAGNOSIS, risk management, Double-Blind Method, Population Groups, Food allergy, Environmental health, medicine, Journal Article, Humans, education, No-Observed-Adverse-Effect Level, 2403 Immunology, decision-making process, business.industry, Public health, Infant, Allergens, Placebo Effect, medicine.disease, Food, Immunization, Population Risk, business
Abstract

Background: Food allergies are a significant public health issue, and the only effective management option currently available is strict avoidance of all foods containing the allergen. In view of the practical impossibility of limiting risks to zero, quantitative allergen risk assessment and management strategies are needed. Objective: We sought to develop appropriate methods for informing population-based risk assessments and risk management programs to benefit all stakeholders but particularly patients with food allergy. Methods: Individual thresholds for food allergens (maximum tolerable doses and minimum eliciting doses) can ideally be established through double-blind, placebo-controlled food challenges. If double-blind, placebo-controlled food challenge data are not available, data from widely used open food challenges using predefined objective criteria can also provide useful data regarding minimum eliciting doses. For more than 20 years, the Netherlands Organisation for Applied Scientific Research and the Food Allergy Research and Resource Program at the University of Nebraska-Lincoln have been collecting individual maximum tolerable doses and minimum eliciting doses that produce objective symptoms from published and unpublished clinical data to better refine knowledge regarding the sensitivity of the population to food allergens. Results: In this article we provide in-depth insights into the methodology applied by the Netherlands Organisation for Applied Scientific Research and Food Allergy Research and Resource Program to derive individual maximum tolerable doses and minimum eliciting doses for objective symptoms from clinical food challenge data. More than 90 examples for determining individual allergic thresholds are presented. Conclusion: With the methodology presented in this article, we aim to stimulate harmonization and transparency in quantitative food allergen risk assessment and risk management programs, encouraging their wider adoption. © 2019 American Academy of Allergy, Asthma & Immunology

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results