48 results on '"Antenucci, R."'
Search Results
2. When the practice does not meet the theory: results from an Italian survey on the clinical and pathway management of inpatients with decompressive craniectomy or cranioplasty admitted to rehabilitation
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La Porta, F, Formisano, R, Iaccarino, C, Lavezzi, S, Pompucci, A, Estraneo, A, De Tanti, A, Achilli, M, Acler, M, Antenucci, R, Avesani, R, Bagnato, S, Battistini, A, Bellaviti, G, Bertoni, M, Brianti, R, Carboncini, M, Castelli, E, Castronovo, G, Chiapparino, C, Colombo, V, Cosentino, E, De Cicco, D, Fassio, C, Felicita, P, Gambarelli, C, Gambrain, M, Gentile, S, Intiso, D, Lombardi, F, Lucca, L, Maggioni, G, Marino, S, Montis, A, Nardone, A, Perin, C, Premoselli, S, Romoli, A, Salvi, G, Scarponi, F, Tedesco, L, Vezzadini, G, La Porta F., Formisano R., Iaccarino C., Lavezzi S., Pompucci A., Estraneo A., De Tanti A., Achilli M. P., Acler M., Antenucci R., Avesani R., Bagnato S., Battistini A., Bellaviti G., Bertoni M., Brianti R., Carboncini M. C., Castelli E., Castronovo G., Chiapparino C., Colombo V., Cosentino E., De Cicco D., Fassio C., Felicita P., Gambarelli C., Gambrain M., Gentile S., Intiso D., Lombardi F., Lucca L. F., Maggioni G., Marino S., Montis A., Nardone A., Perin C., Premoselli S., Romoli A. M., Salvi G. P., Scarponi F., Tedesco L., Vezzadini G., La Porta, F, Formisano, R, Iaccarino, C, Lavezzi, S, Pompucci, A, Estraneo, A, De Tanti, A, Achilli, M, Acler, M, Antenucci, R, Avesani, R, Bagnato, S, Battistini, A, Bellaviti, G, Bertoni, M, Brianti, R, Carboncini, M, Castelli, E, Castronovo, G, Chiapparino, C, Colombo, V, Cosentino, E, De Cicco, D, Fassio, C, Felicita, P, Gambarelli, C, Gambrain, M, Gentile, S, Intiso, D, Lombardi, F, Lucca, L, Maggioni, G, Marino, S, Montis, A, Nardone, A, Perin, C, Premoselli, S, Romoli, A, Salvi, G, Scarponi, F, Tedesco, L, Vezzadini, G, La Porta F., Formisano R., Iaccarino C., Lavezzi S., Pompucci A., Estraneo A., De Tanti A., Achilli M. P., Acler M., Antenucci R., Avesani R., Bagnato S., Battistini A., Bellaviti G., Bertoni M., Brianti R., Carboncini M. C., Castelli E., Castronovo G., Chiapparino C., Colombo V., Cosentino E., De Cicco D., Fassio C., Felicita P., Gambarelli C., Gambrain M., Gentile S., Intiso D., Lombardi F., Lucca L. F., Maggioni G., Marino S., Montis A., Nardone A., Perin C., Premoselli S., Romoli A. M., Salvi G. P., Scarponi F., Tedesco L., and Vezzadini G.
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BACKGROUND: Cranioplasty (CP) is supposed to improve the functional outcome of severe acquired brain injury (sABI) patients with decompressive craniectomy (DC). However, ongoing controversies exist regarding its indications, optimum materials, timing, complications, and relationships with hydrocephalus (HC). For these reasons, an International Consensus Conference (ICC) on CP in traumatic brain injury (TBI) was held in June 2018 to issue some recommendations. AIM: The aims of this study were: to investigate cross-sectionally before the ICC the prevalence of DC/CP in sABI inpatients admitted to neu- rorehabilitation units in Italy; to assess the perception of Italian clinicians working in the sABI neurorehabilitation settings on the management of inpatients with DC/CP during their rehabilitation stay. DESIGN: Cross-sectional. SETTING AND POPULATION: Physiatrists or neurologists working in 38 Italian rehabilitation centers involved in the care of sABI, giving a pooled sample of 599 inpatients. METHODS: Survey questionnaire consisting of 21 closed-ended questions with multiple-choice answers. Sixteen questions regarded the respondents' opinions and experiences regarding the clinical and management aspects of patients. Survey data were collected via e-mail between April and May 2018. RESULTS: About 1/3 of the 599 inpatients had either a DC (18.9%) or a CP (13.5%). TBI and cerebral hemorrhage were strongly associated with DC/CP, although the association was much stronger for TBI. Significant discrepancies were uncovered between some of the recommendations of the ICC and the corresponding perceptions of the respondents, especially regarding the clinical management of patients (i.e., CP timing). Clear guidelines were perceived as the most crucial factor in improving clinical pathways. CONCLUSIONS: Early collaboration between the neurosurgical and the neurorehabilitation teams is crucial to optimize all clinical and organizational factors, which could expedite CP and minimi
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- 2023
3. Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies
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Estraneo, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, De Bellis, F, Estraneo A., Masotta O., Bartolo M., Pistoia F., Perin C., Marino S., Lucca L., Pingue V., Casanova E., Romoli A., Gentile S., Formisano R., Salvi G. P., Scarponi F., De Tanti A., Bongioanni P., Rossato E., Santangelo A., Diana A. R., Gambarin M., Intiso D., Antenucci R., Premoselli S., Bertoni M., De Bellis F., Estraneo, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, De Bellis, F, Estraneo A., Masotta O., Bartolo M., Pistoia F., Perin C., Marino S., Lucca L., Pingue V., Casanova E., Romoli A., Gentile S., Formisano R., Salvi G. P., Scarponi F., De Tanti A., Bongioanni P., Rossato E., Santangelo A., Diana A. R., Gambarin M., Intiso D., Antenucci R., Premoselli S., Bertoni M., and De Bellis F.
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Aim: to assess overall clinical complexity of patients with acquired disorders of consciousness (DoC) in vegetative state/unresponsive wakefulness syndrome (VS/UWS) vs. minimally conscious state- MCS) and in different etiologies. Design: Multi-center cross-sectional observational study. Setting: 23 intensive neurorehabilitation units. Subjects: 264 patients with DoC in the post-acute phase: VS/UWS = 141, and MCS = 123 due to vascular (n = 125), traumatic (n = 83) or anoxic (n = 56) brain injury. Main Measures: Coma Recovery Scale-Revised, and Disability Rating Scale (DRS); presence of medical devices (e.g., for eating or breathing); occurrence and severity of medical complications. Results: patients in DoC, and particularly those in VS/UWS, showed severe overall clinical complexity. Anoxic patients had higher overall clinical complexity, lower level of responsiveness/consciousness, higher functional disability, and higher needs of medical devices. Vascular patients had worse premorbid clinical comorbidities. The two etiologies showed a comparable rate of MC, higher than that observed in traumatic etiology. Conclusion: overall clinical complexity is significantly higher in VS/UWS than in MCS, and in non-traumatic vs. traumatic etiology. These findings could explain the worse clinical evolution reported in anoxic and vascular etiologies and in VS/UWS patients and contribute to plan patient-tailored care and rehabilitation programmes.
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- 2021
4. Multi-center observational study on occurrence and related clinical factors of neurogenic heterotopic ossification in patients with disorders of consciousness
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Estraneo, A, Pascarella, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, Trojano, L, Estraneo A., Pascarella A., Masotta O., Bartolo M., Pistoia F., Perin C., Marino S., Lucca L., Pingue V., Casanova E., Romoli A. M., Gentile S., Formisano R., Salvi G. P., Scarponi F., De Tanti A., Bongioanni P., Rossato E., Santangelo A., Diana A. R., Gambarin M., Intiso D., Antenucci R., Premoselli S., Bertoni M., Trojano L., Estraneo, A, Pascarella, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, Trojano, L, Estraneo A., Pascarella A., Masotta O., Bartolo M., Pistoia F., Perin C., Marino S., Lucca L., Pingue V., Casanova E., Romoli A. M., Gentile S., Formisano R., Salvi G. P., Scarponi F., De Tanti A., Bongioanni P., Rossato E., Santangelo A., Diana A. R., Gambarin M., Intiso D., Antenucci R., Premoselli S., Bertoni M., and Trojano L.
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Aims: to assess occurrence and clinical correlates of neurogenic heterotopic ossifications (NHO) in patients with prolonged disorder of consciousness (DoC). Design: multi-center cross-sectional observational study. Setting: 23 intensive neurorehabilitation units. Subjects: 287 patients with prolonged disorder of consciousness (DoC; 150 in vegetative state, VS, and 128 in minimally conscious state, MCS) of different etiology (vascular = 125, traumatic = 83, anoxic = 56, others = 14). Main Measures: clinical evidence of NHO confirmed by standard radiological and/or sonographic evaluation; Coma Recovery Scale-Revised; Disability Rating Scale (DRS); Early Rehabilitation Barthel Index; presence of ventilator support, spasticity, bone fractures and paroxysmal sympathetic hyperactivity. Results: 31 patients (11.2%) presented NHO. Univariate analyses showed that NHO was associated with VS diagnosis, traumatic etiology, high DRS category and total score, and high occurrence of limb spasticity and bone fractures. A cluster-corrected binary logistic regression model (excluding spasticity available in a subset of patients) showed that only lower DRS total score and presence of bone fractures were independently associated with NHO. Conclusions: NHO are relatively frequent in patients with DoC, and are independently associated with functional disability, bone fractures and spasticity. These findings contribute to identifying patients with DoC prone to develop NHO and requiring special interventions to improve functional recovery.
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- 2021
5. Nonnutritive sweeteners are not supernormal stimuli
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Antenucci, R G and Hayes, J E
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- 2015
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6. Fat and calorie-modified bakery products
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Barndt, R. L., Antenucci, R. N., and Khan, Riaz, editor
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- 1993
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7. What is the impact of robotic rehabilitation on balance and gait outcomes in people with multiple sclerosis? A systematic review of randomized control trials
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Bowman, T., Gervasoni, E., Amico, A. P., Antenucci, R., Benanti, P., Boldrini, P., Bonaiuti, D., Burini, A., Castelli, E., Francesco, Draicchio, Falabella, V., Galeri, S., Gimigliano, F., Grigioni, M., Mazzon, S., Mazzoleni, S., Mestanza Mattos, F. G., Molteni, F., Morone, G., Petrarca, M., Picelli, A., Posteraro, F., Senatore, M., Turchetti, G., Crea, S., Cattaneo, D., Carrozza, M. C., Baricich, A., Bissolotti, L., Capecci, M., Cavalli, L., Di Stefano, G., Jonsdottir, J., Lentino, C., Massai, P., Morelli, S., Nardone, A., Panzeri, D., Taglione, E., Bowman, T., Gervasoni, E., Amico, A. P., Antenucci, R., Benanti, P., Boldrini, P., Bonaiuti, D., Burini, A., Castelli, E., Francesco, Draicchio, Falabella, V., Galeri, S., Gimigliano, F., Grigioni, M., Mazzon, S., Mazzoleni, S., Mestanza Mattos, F. G., Molteni, F., Morone, G., Petrarca, M., Picelli, A., Posteraro, F., Senatore, M., Turchetti, G., Crea, S., Cattaneo, D., Carrozza, M. C., Baricich, A., Bissolotti, L., Capecci, M., Cavalli, L., Di Stefano, G., Jonsdottir, J., Lentino, C., Massai, P., Morelli, S., Nardone, A., Panzeri, D., and Taglione, E.
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medicine.medical_specialty ,medicine.medical_treatment ,Physical Therapy, Sports Therapy and Rehabilitation ,Context (language use) ,Walk Test ,Cochrane Library ,law.invention ,Multiple sclerosis ,Disability Evaluation ,Physical medicine and rehabilitation ,Gait training ,Randomized controlled trial ,law ,Multiple Sclerosi ,Neurologic ,Medicine ,Humans ,Gait Disorders ,Gait ,Gait Disorders, Neurologic ,Randomized Controlled Trials as Topic ,Rehabilitation ,Robotics ,Combined Modality Therapy ,Multiple Sclerosis ,Exoskeleton Device ,business.industry ,Evidence-based medicine ,Robotic ,Berg Balance Scale ,business ,human activities ,Human - Abstract
Introduction In recent years, robot-assisted gait training (RAGT) has been proposed as therapy for balance and gait dysfunctions in people with multiple sclerosis (PwMS). Through this systematic review, we aimed to discuss the impact of RAGT on balance and gait outcomes. Furthermore, characteristics of the training in terms of robots used, participants characteristics, protocols and combined therapeutic approaches have been described. Evidence acquisition As part of the Italian Consensus on robotic rehabilitation "CICERONE" a systematic search was provided in PubMed, the Cochrane Library and PEDro to identify relevant studies published before December 2019. Only randomized control trials (RCT) involving RAGT for PwMS were included. PEDro scale was used to assess the risk of bias and the Oxford Center for Evidence-Based Medicine (OCEBM) was used to assess level of evidence of included studies. Evidence synthesis The search on databases resulted in 336 records and, finally, 12 studies were included. RAGT was provided with Exoskeleton in ten studies (6-40 session, 2-5 per week) and with end-effector in two studies (12 sessions, 2-3 per week) with large variability in terms of participants' disability. All the exoskeletons were combined with bodyweight support treadmill and movement assistance varied from 0% to 100% depending on participants' disability, two studies combined exoskeleton with virtual reality. The end-effector speed ranged between 1.3 and 1.8 km/h, with bodyweight support starting from 50% and progressively reduced. In seven out of twelve studies RAGT was provided in a multimodal rehabilitation program or in combination with standard physical therapy. There is level 2 evidence that RAGT has positive impact in PwMS, reaching the minimally clinically importance difference in Berg Balance Scale, six-minute walking test and gait speed. Conclusions In available RCT, RAGT is mostly provided with exoskeleton devices and improves balance and gait outcomes in a clinically meaningful way. Considering several advantages in terms of safety, motor assistance and intensity of training provided, RAGT should be promoted for PwMS with severe disability in a multimodal rehabilitation context as an opportunity to maximize recovery.
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- 2021
8. Multi-center observational study on occurrence and related clinical factors of neurogenic heterotopic ossification in patients with disorders of consciousness
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Estraneo, A, primary, Pascarella, A, additional, Masotta, O, additional, Bartolo, M, additional, Pistoia, F, additional, Perin, C, additional, Marino, S, additional, Lucca, L, additional, Pingue, V, additional, Casanova, E, additional, Romoli, AM, additional, Gentile, S, additional, Formisano, R, additional, Salvi, GP, additional, Scarponi, F, additional, De Tanti, A, additional, Bongioanni, P, additional, Rossato, E, additional, Santangelo, A, additional, Diana, AR, additional, Gambarin, M, additional, Intiso, D, additional, Antenucci, R, additional, Premoselli, S, additional, Bertoni, M, additional, and Trojano, L, additional
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- 2021
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9. Aspectos relevantes para el éxito en la cementación de los pernos fibra de vidrio.
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Zavanelli, A. C., Falcón-Antenucci, R. M., dos Santos Neto, O. M., Zavanelli, R. A., and Mazaro, J. V. Q.
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Copyright of Avances en Odontoestomatologia is the property of Ediciones Avances SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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10. Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies
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Estraneo, A, primary, Masotta, O, additional, Bartolo, M, additional, Pistoia, F, additional, Perin, C, additional, Marino, S, additional, Lucca, L, additional, Pingue, V, additional, Casanova, E, additional, Romoli, A, additional, Gentile, S, additional, Formisano, R, additional, Salvi, GP, additional, Scarponi, F, additional, De Tanti, A, additional, Bongioanni, P, additional, Rossato, E, additional, Santangelo, A, additional, Diana, AR, additional, Gambarin, M, additional, Intiso, D, additional, Antenucci, R, additional, Premoselli, S, additional, Bertoni, M, additional, and De Bellis, F, additional
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- 2020
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11. A Multi-Centric Observational Study on Heterotopic Ossification in Severely Brain-Injured Patients with Disorders of Consciousness: Preliminary Data
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Masotta, O, Pascarella, A, Loreto, V, Trojano, L, Formisano, R, Bartol, M, Aabid, H, Perin, C, Pistoia, F, Sara, M, Nardone, A, Berlusconi, M, Marino, S, Lucca, L, Gentile, S, Piperno, R, Casanova, E, Romoli, A, Scarponi, F, Patriarca, E, Carboncini, M, Avesani, R, Sant'Angelo, N, Intiso, D, Diana, A, Pilia, F, Salvi, G, Gambarin, M, Premoselli, S, De Tanti, A, Bertoni, M, Biacchi, D, Antenucci, R, Estraneo, A, Romoli, AM, Carboncini, MC, Diana, AR, Salvi, GP, Masotta, O, Pascarella, A, Loreto, V, Trojano, L, Formisano, R, Bartol, M, Aabid, H, Perin, C, Pistoia, F, Sara, M, Nardone, A, Berlusconi, M, Marino, S, Lucca, L, Gentile, S, Piperno, R, Casanova, E, Romoli, A, Scarponi, F, Patriarca, E, Carboncini, M, Avesani, R, Sant'Angelo, N, Intiso, D, Diana, A, Pilia, F, Salvi, G, Gambarin, M, Premoselli, S, De Tanti, A, Bertoni, M, Biacchi, D, Antenucci, R, Estraneo, A, Romoli, AM, Carboncini, MC, Diana, AR, and Salvi, GP
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- 2019
12. Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experience
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Mancardi, Gl, Sormani, Mp, Di Gioia, M, Vuolo, L, Gualandi, F, Amato, Mp, Capello, E, Currò, D, Uccelli, A, Bertolotto, A, Gasperini, C, Lugaresi, A, Merelli, E, Meucci, G, Motti, L, Tola, Mr, Scarpini, E, Repice, Am, Massacesi, L, Saccardi, R, Donnini, I, Bosi, A, Guidi, S, Bagigalupo, A, Bonzano, L, Bruzzi, P, Roccatagliata, L, Antenucci, R, Granella, F, Martino, G, Rottoli, M, Solaro, C, Salvi, F, Ursino, E, Barilaro, A, Capobianco, M., Mancardi G, Sormani M, Di Gioia M, Vuolo L, Gualandi F, Amato M, Capello E, Currò D, Uccelli A, Bertolotto A, Gasperini C, Lugaresi A, Merelli E, Meucci G, Motti L, Tola M, Scarpini E, Repice A, Massacesi L, and Saccardi R
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Adult ,medicine.medical_specialty ,Time Factors ,Transplantation Conditioning ,Adolescent ,medicine.medical_treatment ,multiple sclerosis, treatment, prognosis, autologous stem cell transplantation ,Kaplan-Meier Estimate ,Severity of Illness Index ,Transplantation, Autologous ,Disease-Free Survival ,Disability Evaluation ,Young Adult ,Multiple Sclerosis, Relapsing-Remitting ,Autologous stem-cell transplantation ,Refractory ,Predictive Value of Tests ,medicine ,Humans ,Registries ,Multi centre ,Chi-Square Distribution ,business.industry ,Multiple sclerosis ,Hematopoietic Stem Cell Transplantation ,Immunosuppression ,Middle Aged ,Multiple Sclerosis, Chronic Progressive ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Transplantation ,Haematopoiesis ,Treatment Outcome ,Italy ,Neurology ,Disease Progression ,Neurology (clinical) ,Stem cell ,business - Abstract
Background: Over recent years numerous patients with severe forms of multiple sclerosis (MS) refractory to conventional therapies have been treated with intense immunosuppression followed by autologous haematopoietic stem cell transplantation (AHSCT). The clinical outcome and the toxicity of AHSCT can be diverse, depending on the various types of conditioning protocols and on the disease phase. Objectives: To report the Italian experience on all the consecutive patients with MS treated with AHSCT with an intermediate intensity conditioning regimen, named BEAM/ATG, in the period from 1996 to 2008. Methods: Clinical and magnetic resonance imaging outcomes of 74 patients were collected after a median follow-up period of 48.3 (range = 0.8–126) months. Results: Two patients (2.7%) died from transplant-related causes. After 5 years, 66% of patients remained stable or improved. Among patients with a follow-up longer than 1 year, eight out of 25 subjects with a relapsing–remitting course (31%) had a 6–12 months confirmed Expanded Disability Status Scale improvement > 1 point after AHSCT as compared with one out of 36 (3%) patients with a secondary progressive disease course ( p = 0.009). Among the 18 cases with a follow-up longer than 7 years, eight (44%) remained stable or had a sustained improvement while 10 (56%), after an initial period of stabilization or improvement with median duration of 3.5 years, showed a slow disability progression. Conclusions: This study shows that AHSCT with a BEAM/ATG conditioning regimen has a sustained effect in suppressing disease progression in aggressive MS cases unresponsive to conventional therapies. It can also cause a sustained clinical improvement, especially if treated subjects are still in the relapsing–remitting phase of the disease.
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- 2011
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13. Recovery of swallowing in two patients in post-acute phase whit severe dysphagia from Wallemberg Syndrome by combined use of conventional therapy, electro stimulator and iopi device
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Raggi R, Antenucci R, Benvenuti M, Ferrari G, and Cuda D
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- 2016
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14. Dysphagia, Food and Social Networks: Ricetta Soffice Contest a New Experience OF DYSPHAGIA GROUP AUSL PIACENZA
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Benvenuti M, Antenucci R, Raggi R, Cardinali C, Olizzi B, Barbieri S, and Cuda D
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- 2016
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15. Prescribing practice and off-label use of psychotropic medications in post-acute brain injury rehabilitation centres: A cross-sectional survey
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Pisa, Federica Edith, Cosano, Giorgia, Giangreco, Manuela, Giorgini, Tullio, Biasutti, Emanuele, Barbone, Fabio, Formisano, R., Buzzi, M. G., Pistarini, C., Aiachini, B., Basaglia, Nino, Montis, A., Lucca, L. F., Lombardi, F., Ranza, E., Vallasciani, M., Celentano, A., Naldi, A., Castellani, G., Lamberti, G., Lanzillo, B., Posteraro, F., Logi, F., Molteni, F., Lanfranchi, M., Gramigna, C., Bertagnoni, G., Dell'Oste, P., Tonin, P., Iaia, V., Sagliocco, L., Beatrici, M., Giunta, N., Dore, T., Galardi, G., Sant'Angelo, N., Piperno, R., Battistini, A., Zampolini, M., Scarponi, F., Sanna, V., Biella, A. M., Premoselli, S., Zaro, F., Bernasconi, K., Carnovali, M., Chierici, S., Antenucci, R., Salvi, G. P., Mazzini, N., Ventura, F., Lonati, M. C., Brianti, R., Mammi, P., Molinero, G., De Tanti, A., Bertolino, C., Boldrini, P., Bargellesi, S., and Tessari, A.
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Adult ,Male ,medicine.medical_specialty ,Cross-sectional study ,medicine.medical_treatment ,Neuroscience (miscellaneous) ,Practice Patterns ,Logistic regression ,Off-label use ,Rehabilitation Centers ,NO ,Pharmacotherapy ,Arts and Humanities (miscellaneous) ,medicine ,Antiepileptic agents ,Prevalence ,Developmental and Educational Psychology ,Antipsychotics ,Humans ,Practice Patterns, Physicians' ,Psychiatry ,Survey ,Psychotropic Drugs ,Rehabilitation ,Physicians' ,Off-label ,business.industry ,Pharmacoepidemiology ,Acquired brain injuries ,Antidepressants ,Prescribing ,Psychotropic medications ,Brain Injuries ,Cross-Sectional Studies ,Female ,Italy ,Middle Aged ,Off-Label Use ,Neurology (clinical) ,Odds ratio ,Confidence interval ,Emergency medicine ,business - Abstract
Guidance on pharmacotherapy of neurobehavioural sequelae post-acquired brain injury (ABI) is limited. Clinicians face the choice of prescribing off-label. This survey assesses prescribing practice and off-label use of psychotropic medications in Italian brain injury rehabilitation centres and factors associated with atypical antipsychotics use.Centres were identified through the roster of the Italian Society for Rehabilitation Medicine. Information was collected through a structured questionnaire. This study calculated the prevalence of centres reporting to use off-label individual medications and unconditional logistic regression Odds Ratio (OR), with 95% confidence interval (95% CI) of atypical antipsychotics use.Psychotropic medications were commonly used. More than 50% of the 35 centres (participation ratio 87.5%) reported to use off-label selected antipsychotics, mostly for agitation (90.5%) and behavioural disturbances (19.0%), and antidepressants, mostly for insomnia (37.5%) and pain (25.0%). Atypical antipsychotic use was directly associated with age40 years (OR = 2.68; 95% CI = 1.25-5.76), recent ABI (1.74; 0.74-4.09), not with reported off-label use (0.98; 0.44-2.18).In clinical practice, the effectiveness and safety of medications, in particular off-label, should be systematically monitored. Studies are needed to improve the quality of evidence guiding pharmacotherapy and to evaluate effectiveness and safety of off-label prescribing.
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- 2015
16. Early rehabilitation for severe acquired brain injury in intensive care unit: Multicenter observational study
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Bartolo, M, Bargellesi, S, Castioni, C, Bonaiuti, D, Antenucci, R, Benedetti, A, Capuzzo, V, Gamna, F, Radeschi, G, Citerio, G, Colombo, C, Del Casale, L, Recubini, E, Toska, S, Zanello, M, D'Aurizio, C, Spina, T, Del Gaudio, A, Di Rienzo, F, Intiso, D, Dallocchio, G, Felisatti, G, Lavezzi, S, Zoppellari, R, Gariboldi, V, Lorini, L, Melizza, G, Molinero, G, Mandalà, G, Pignataro, A, Montis, A, Napoleone, A, Pilia, F, Pisu, M, Semerjian, M, Pagliaro, G, Nardin, L, Scarponi, F, Zampolini, M, Zava, R, Massetti, M, Piccolini, C, Aloj, F, Antonelli, S, Zucchella, C, Lorini, F, Zucchella, C., LORINI, FERDINANDO LUCA, CITERIO, GIUSEPPE, Bartolo, M, Bargellesi, S, Castioni, C, Bonaiuti, D, Antenucci, R, Benedetti, A, Capuzzo, V, Gamna, F, Radeschi, G, Citerio, G, Colombo, C, Del Casale, L, Recubini, E, Toska, S, Zanello, M, D'Aurizio, C, Spina, T, Del Gaudio, A, Di Rienzo, F, Intiso, D, Dallocchio, G, Felisatti, G, Lavezzi, S, Zoppellari, R, Gariboldi, V, Lorini, L, Melizza, G, Molinero, G, Mandalà, G, Pignataro, A, Montis, A, Napoleone, A, Pilia, F, Pisu, M, Semerjian, M, Pagliaro, G, Nardin, L, Scarponi, F, Zampolini, M, Zava, R, Massetti, M, Piccolini, C, Aloj, F, Antonelli, S, Zucchella, C, Lorini, F, Zucchella, C., LORINI, FERDINANDO LUCA, and CITERIO, GIUSEPPE
- Abstract
Background: The increased survival after a severe acquired brain injury (sABI) raise the problem of making most effective the treatments in Intensive Care Unit (ICU)/Neurointensive Care Unit (NICU), also integrating rehabilitation care. Despite previous studies reported that early mobilization in ICU was effective in preventing complications and reducing hospital stay, few studies addressed the rehabilitative management of sABI patients in ICU/NICU. Aim: To collect clinical and functional data about the early rehabilitative management of sABI patients during ICU/NICU stay. Design. Prospective, observational, multicenter study. Setting: Fourteen facilities supplied by intensive neurorehabilitation units and ICU/NICUs. Population : Consecutive sABI patients admitted to ICU/NICU. Methods: Patients were evaluated at admission and then every 3-5 days. Clinical, functional and rehabilitative data, including Glasgow Coma Scale (GCS), Disability Rating Scale (DRS), The Rancho Los Amigos Levels of Cognitive Functioning Scale (LCF), Early Rehabilitation Barthel Index (ERBI), Glasgow Outcome scale (GOS) and Functional Independence Measure (FIM) were collected. Results : One hundred and two patients (F/M 44/58) were enrolled. The mean duration of ICU stay was 24.7±13.9 days and the first rehabilitative evaluation occurred after 8.7±8.8 days. Regular postural changes and multijoint mobilization were prescribed in 63.7% and 64.7% cases, respectively. The mean session duration was 38±11.5 minutes. Swallowing evaluation was performed in 14.7% patients, psychological support was provided to 12.7% of patients' caregivers, while 17.6% received a psycho-educational intervention, and 28.4% were involved in interdisciplinary team meetings. The main discharge destinations were Severe Acquired Brain Injury rehabilitation units for 43.7%, intensive neurorehabilitation units for 20.7%. Conclusions: Data showed that early rehabilitation was not diffusely performed in sABI subjects in ICU/NICU
- Published
- 2016
17. Evaluación del efecto de prensado en prótesis totales maxilares sobre la movilidad de los dientes artificiales, en función del tipo de inclusión
- Author
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Gennari Filho, H., Coelho Goiato, M., Mara Negrão Alves, L., Ramos Silva, C., and Mary Falcón Antenucci, R.
- Subjects
Dientes artificiales ,resinas acrílicas ,Artificial teeth ,prótesis totales superiores ,acrylic resins ,upper complete denture - Abstract
El presente trabajo evaluó el movimiento de los dientes artificiales en prótesis totales maxilares, sometidas a diversas presiones durante el prensado y el efecto de este en relación al material usado en la inclusión. Treinta y seis réplicas de prótesis totales previamente confeccionadas, fueran divididas en seis grupos: Los grupos G1, G2 y G3 fueron incluidos con yeso tipo III, a una presión de 800, 1.000 y 1.250 kgf respectivamente y los grupos S1, S2 y S3 fueron incluidos con una barrera de silicona y yeso, a una presión de 800, 1.000 y 1.250 kgf, respectivamente. Las prótesis fueron medidas en puntos demarcados previamente en los segundos molares, premolares e incisivo central con el programa de computación gráfica (AutoCad 2000), después de cada etapa: encerado, polimerización y emuflado. La comparación entre estas dos fases permitió observar que: en los grupos (G1 y S1) donde se utilizó la menor presión (800 kgf) ocurrieron las mayores alteraciones en el posicionamiento de los dientes artificiales y que el grupo que mostró menores alteraciones fue cuando se utilizó 1.250 kgf de presión y la inclusión fue con yeso. The present study evaluated artificial teeth movement in complete dentures, submitted to different flasking loading and the effect of these loading pressures on the material used in the flasking procedure. Thirty-six dentures were fabricated and equally divided into six groups: Groups G1, G2 and G3 were processed with type III gypsum and 800, 1000 and 1250 kgf loading pressures, respectively, and groups S1, S2 and S3 were processed with silicone barrier and 800, 1000 and 1250 kgf loading pressures, respectively. In order to evaluate the artificial teeth movement, measurements were performed from previously determined points down in the second molars tips and in the second pre-molars cusps and in the central incisor. Those points were scanned (Scan Jet 6100C - Hewlett Packard) and then the measurements were performed and analyzed through the use of the AutoCad 2000 software, during the wax and the post-polymerization phases. The comparison between these two phases allowed the following observations: in groups (G1 and S1) where less loading pressure was used (800 kgf), the movements in the artificial teeth positions were the highest, and the group that presented the lowest changes was the one processed with type III gypsum and 1250 kgf loading pressure.
- Published
- 2008
18. Instabilità di rotula : ruolo dell’artroscopia
- Author
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Cerulli, Giuliano Giorgio, Caraffa, Auro, Antenucci, R., Antinolfi, P., and Fantasia, F.
- Published
- 2007
19. Nonnutritive sweeteners are not supernormal stimuli
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Antenucci, R G, primary and Hayes, J E, additional
- Published
- 2014
- Full Text
- View/download PDF
20. Evaluación del efecto de prensado en prótesis totales maxilares sobre la movilidad de los dientes artificiales, en función del tipo de inclusión
- Author
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Gennari Filho, H., primary, Coelho Goiato, M., additional, Mara Negrão Alves, L., additional, Ramos Silva, C., additional, and Mary Falcón Antenucci, R., additional
- Published
- 2008
- Full Text
- View/download PDF
21. Walking after stroke: what does treadmill training with body weight support add to overground gait training in patients early after stroke?: a single-blind, randomized, controlled trial.
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Franceschini M, Carda S, Agosti M, Antenucci R, Malgrati D, Cisari C, Gruppo Italiano Studio Allevio Carico Ictus, Franceschini, Marco, Carda, Stefano, Agosti, Maurizio, Antenucci, Roberto, Malgrati, Daniele, and Cisari, Carlo
- Published
- 2009
- Full Text
- View/download PDF
22. Early rehabilitation for severe acquired brain injury in intensive care unit: Multicenter observational study
- Author
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Bartolo, M, Bargellesi, S, Castioni, C, Bonaiuti, D, Antenucci, R, Benedetti, A, Capuzzo, V, Gamna, F, Radeschi, G, Colombo, C, Del Casale, L, Recubini, E, Toska, S, Zanello, M, D'Aurizio, C, Spina, T, Del Gaudio, A, Di Rienzo, F, Intiso, D, Dallocchio, G, Felisatti, G, Lavezzi, S, Zoppellari, R, Gariboldi, V, Lorini, L, Melizza, G, Molinero, G, Mandalà, G, Pignataro, A, Montis, A, Napoleone, A, Pilia, F, Pisu, M, Semerjian, M, Pagliaro, G, Nardin, L, Scarponi, F, Zampolini, M, Zava, R, Massetti, M, Piccolini, C, Aloj, F, Antonelli, S, Zucchella, C., LORINI, FERDINANDO LUCA, CITERIO, GIUSEPPE, Bartolo, Michelangelo, Bargellesi, Stefano, Castioni, Carlo A, Bonaiuti, Donatella, Antenucci, Roberto, Benedetti, Angelo, Capuzzo, Valeria, Gamna, Federica, Radeschi, Giulio, Citerio, Giuseppe, Colombo, Carolina, Del Casale, Laura, Recubini, Elena, Toska, Saimir, Zanello, Marco, D'Aurizio, Carlo, Spina, Tullio, Del Gaudio, Alredo, Di Rienzo, Filomena, Intiso, Domenico, Dallocchio, Giulia, Felisatti, Giovanna, Lavezzi, Susanna, Zoppellari, Roberto, Gariboldi, Valentina, Lorini, Luca, Melizza, Giovanni, Molinero, Guido, Mandalà, Giorgio, Pignataro, Amedeo, Montis, Andrea, Napoleone, Alessandro, Pilia, Felicita, Pisu, Marina, Semerjian, Monica, Pagliaro, Giuseppina, Nardin, Lorella, Scarponi, Federico, Zampolini, Mauro, Zava, Raffaele, Massetti, Maria A, Piccolini, Carlo, Aloj, Fulvio, Antonelli, Sergio, Zucchella, Chiara, Bartolo, M, Bargellesi, S, Castioni, C, Bonaiuti, D, Antenucci, R, Benedetti, A, Capuzzo, V, Gamna, F, Radeschi, G, Citerio, G, Colombo, C, Del Casale, L, Recubini, E, Toska, S, Zanello, M, D'Aurizio, C, Spina, T, Del Gaudio, A, Di Rienzo, F, Intiso, D, Dallocchio, G, Felisatti, G, Lavezzi, S, Zoppellari, R, Gariboldi, V, Lorini, L, Melizza, G, Molinero, G, Mandalà, G, Pignataro, A, Montis, A, Napoleone, A, Pilia, F, Pisu, M, Semerjian, M, Pagliaro, G, Nardin, L, Scarponi, F, Zampolini, M, Zava, R, Massetti, M, Piccolini, C, Aloj, F, Antonelli, S, Zucchella, C, and Lorini, F
- Subjects
Male ,Critical Care ,health care facilities, manpower, and services ,Intensive Care Unit ,Rehabilitation ,Recovery of Function ,Middle Aged ,Early mobilization ,Hospitalization ,Prospective Studie ,Intensive Care Units ,Treatment Outcome ,Italy ,Brain Injurie ,Brain Injuries ,Humans ,Female ,Glasgow Coma Scale ,Prospective Studies ,Brain injury ,Human ,Aged - Abstract
Background: The increased survival after a severe acquired brain injury (sABI) raise the problem of making most effective the treatments in Intensive Care Unit (ICU)/Neurointensive Care Unit (NICU), also integrating rehabilitation care. Despite previous studies reported that early mobilization in ICU was effective in preventing complications and reducing hospital stay, few studies addressed the rehabilitative management of sABI patients in ICU/NICU. Aim: To collect clinical and functional data about the early rehabilitative management of sABI patients during ICU/NICU stay. Design. Prospective, observational, multicenter study. Setting: Fourteen facilities supplied by intensive neurorehabilitation units and ICU/NICUs. Population : Consecutive sABI patients admitted to ICU/NICU. Methods: Patients were evaluated at admission and then every 3-5 days. Clinical, functional and rehabilitative data, including Glasgow Coma Scale (GCS), Disability Rating Scale (DRS), The Rancho Los Amigos Levels of Cognitive Functioning Scale (LCF), Early Rehabilitation Barthel Index (ERBI), Glasgow Outcome scale (GOS) and Functional Independence Measure (FIM) were collected. Results : One hundred and two patients (F/M 44/58) were enrolled. The mean duration of ICU stay was 24.7±13.9 days and the first rehabilitative evaluation occurred after 8.7±8.8 days. Regular postural changes and multijoint mobilization were prescribed in 63.7% and 64.7% cases, respectively. The mean session duration was 38±11.5 minutes. Swallowing evaluation was performed in 14.7% patients, psychological support was provided to 12.7% of patients' caregivers, while 17.6% received a psycho-educational intervention, and 28.4% were involved in interdisciplinary team meetings. The main discharge destinations were Severe Acquired Brain Injury rehabilitation units for 43.7%, intensive neurorehabilitation units for 20.7%. Conclusions: Data showed that early rehabilitation was not diffusely performed in sABI subjects in ICU/NICU and rehabilitative interventions were variable; one-third of subjects were not referred to dedicated rehabilitation unit at discharge. Clinical Rehabilitation Impact : The study stresses the need to spread and implement a rehabilitative culture also for critical ill patients due to neurological diseases.
23. Operative arthroscopy of the ankle
- Author
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SCHIAVONE PANNI, Alfredo, Cerulli, G., Antenucci, R., Caraffa, A., and Bensi, G.
- Published
- 1989
24. Profilassi antitetanica mirata nei feriti
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Perito, Stefano, Bastianini, L., Antenucci, R., and Pitzurra, Lucia
- Published
- 1982
25. Effect of occlusion on joint sounds in asymptomatic individuals
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Garcia, A. R., Zuim, P. R., marcelo Coelho goiato, Dos Santos, P. H., Ribeiro, A. B., Pita, M. S., and Flacón-Antenucci, R. M.
26. Evaluation of hardness and color stability in the soft lining materials after thermocycling and chemical polishing
- Author
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Goiato, M. C., Falcón-Antenucci, R. M., Santos, D. M., and Eduardo Pellizzer
27. Turkey red blood cell passive haemagglutination assay as guideline for specific prevention of tetanus in injured persons
- Author
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Bistoni, F., Marconi, P., STEFANO PERITO, Bastianini, L., Antenucci, R., and Pitzurra, M.
- Subjects
Turkeys ,Erythrocytes ,Tetanus ,Research ,Clostridium tetani ,Animals ,Humans ,Enzyme-Linked Immunosorbent Assay ,Hemagglutination Tests ,Antibodies, Bacterial - Abstract
Turkey red blood cell passive haemagglutination assays (TRBC-HA) were carried out on serum samples from 873 injured patients in order to compare individual prophylactic treatment against tetanus based on the anti-tetanus antibody levels with interventions based on anamnestic criteria. The results showed a great difference: according to the anamnesis 124 persons (14.2%) were protected, 253 (29%) were partially protected, and 496 (56.8%) were unprotected; according to the TRBC-HA assay, 479 (54.9%) were protected, 279 (32%) partially protected, and 115 (13.2%) unprotected.The efficiency of the prophylactic treatments given on the basis of the two criteria was also compared in a study of 129 injured patients who were divided in two groups: group 1 (50 patients) received 250 IU of human tetanus immunoglobulin (HTI) regardless of their tetanus immunity, and group II (79 patients) received appropriate or no treatment depending on the level of anti-tetanus antibodies determined by TRBC-HA assay. The results showed that prophylactic interventions based on the anti-tetanus antibody levels can give protection in 100% of injured patients at minimum cost and risk.
28. Early rehabilitation for severe acquired brain injury in intensive care unit: multicenter observational study
- Author
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Bartolo M, Bargellesi S, Ca, Castioni, Bonaiuti D, Intensive Care and Neurorehabilitation Italian Study Group, Antenucci R, Benedetti A, Capuzzo V, and Zucchella C
29. Evaluation of hardness and color stability in the soft lining materials after thermocycling and chemical polishing
- Author
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marcelo Coelho goiato, Falcón-Antenucci, R. M., Santos, D. M., and Pellizzer, E. P.
30. Evaluation of dimensional change and detail reproduction in silicones for facial prostheses
- Author
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Goiato, M. C., Aldiéris Pesqueira, Dos Santos, D. M., Antenucci, R. M., and Ribeiro, P. P.
31. Stroke and rehabilitation: Italian Cooperative Research (ICR2)
- Author
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Franceschini, M., Branchini, W., Rodolfo Brianti, Camillis, E., Ferrari, L., Galvagni, R., Lenti, G., Manca, M., Mayer, F., Molteni, F., Perdon, L., Procicchiani, D., Todeschini, E., Zaccala, M., Agosti, M., Casella, G., Celani, M. G., Citterio, A., Masucci, M., Spizzichino, L., Vallasciani, M., Recupero, E., Finocchiaro, F., Santagati, A., Greco, S., Longo, P., Comessatti, C., Taroni, B., Cosentino, E., Biondi, T., Mugelli, C., Maria Rossi, R., Serra, A., Bertoni, M., Meinecke, C., Fabbrini, S., Confalonieri, D., Ceruti, R., Fortina, C., Zaccaria, B., Meneghetti, S., Robuschi, K., Michelotti, V., Cavaldonati, A., Sandrini, G., Arrigo, A., Antenucci, R., Gandolfi, P., Gatta, G., Boschini, L., Dardani, M., Massucci, M., Braconi, A. R., Bortoluzzi, N., and Timar, J.
32. Effects of robot-assisted gait training on postural instability in parkinson's disease: A systematic review
- Author
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Perla Massai, Paolo Benanti, Enrico Castelli, Angelo P. Amico, Donatella Bonaiuti, Antonio Nardone, Silvia Galeri, Rita Di Censo, Stefano Mazzoleni, Giuseppina Di Stefano, Stefano Mazzon, Johanna Jonsdodttir, Valentina Varalta, Mirko Filippetti, Giuseppe Turchetti, Vincenzo Falabella, Michele Senatore, Cristina Fonte, Daniele Panzeri, Loredana Cavalli, Francesco Draicchio, Alessandro Picelli, R Antenucci, Sandra Morelli, Thomas Bowman, Alessio Baricich, Alessandro Zadra, Marianna Capecci, Federico Posteraro, Elisa Taglione, Francesca Gimigliano, Franco Molteni, Giovanni Morone, Paolo Boldrini, Irene Chignola, Maurizio Petrarca, Luciano Bissolotti, Mauro Grigioni, Stefano Scarpa, Carmelo Lentino, Picelli, A., Capecci, M., Filippetti, M., Varalta, V., Fonte, C., Censo, R. D., Zadra, A., Chignola, I., Scarpa, S., Amico, A. P., Antenucci, R., Baricich, A., Benanti, P., Bissolotti, L., Boldrini, P., Bonaiuti, D., Castelli, E., Cavalli, L., Stefano, G. D., Draicchio, F., Ella, V. F., Galeri, S., Gimigliano, F., Grigioni, M., Jonsdodttir, J., Lentino, C., Massai, P., Mazzoleni, S., Mazzon, S., Eni, F. M., Morelli, S., Morone, G., Zeri, D. P., Petrarca, M., Posteraro, F., Senatore, M., Glione, E. T., Turchetti, G., Bowman, T., and Nardone, A.
- Subjects
medicine.medical_specialty ,Parkinson's disease ,medicine.medical_treatment ,Physical Therapy, Sports Therapy and Rehabilitation ,law.invention ,Physical medicine and rehabilitation ,Gait (human) ,Randomized controlled trial ,Gait training ,law ,Postural Balance ,medicine ,Neurologic ,Humans ,Gait Disorders ,Parkinson disease ,Postural balance ,Robotics ,Rehabilitation ,Gait Disorders, Neurologic ,Balance (ability) ,business.industry ,Parkinson Disease ,medicine.disease ,Exoskeleton Device ,Robotic ,Systematic review ,business ,human activities ,Human - Abstract
Introduction Postural instability is a cardinal feature of Parkinson's disease, together with rest tremor, rigidity and bradykinesia. It is a highly disabling symptom that becomes increasingly common with disease progression and represents a major source of reduced quality of life in patients with Parkinson's disease. Rehabilitation aims to enable patients with Parkinson's disease to maintain their maximum level of mobility, activity and independence. To date, a wide range of rehabilitation approaches has been employed to treat postural instability in Parkinson's disease, including robotic training. Our main aim was to conduct a systematic review of current literature about the effects of robot-assisted gait training on postural instability in patients with Parkinson's disease. Evidence acquisition A systematic search using the following MeSH terms "Parkinson disease," "postural balance," "robotics," "rehabilitation" AND string "robotics [mh]" OR "robot-assisted" OR "electromechanical" AND "rehabilitation [mh]" OR "training" AND "postural balance [mh]" was conducted on PubMed, Cochrane Library and Pedro electronic databases. Full text articles in English published up to December 2020 were included. Data about patient characteristics, robotic devices, treatment procedures and outcome measures were considered. Every included article got checked for quality. Level of evidence was defined for all studies. Evidence synthesis Three authors independently extracted and verified data. In total, 18 articles (2 systematic reviews, 9 randomized controlled trials, 4 uncontrolled studies and 3 case series/case reports) were included. Both end-effector and exoskeleton devices were investigated as to robot-assisted gait training modalities. No clear relationship between treatment parameters and clinical conditions was observed. We found a high level of evidence about the effects of robot-assisted gait training on balance and freezing of gait in patients with Parkinson's disease. Conclusions This systematic review provides to the reader a complete overview of current literature and levels of evidence about the effects of robot-assisted gait training on postural instability issues (static and dynamic balance, freezing of gait, falls, confidence in activities of daily living and gait parameters related to balance skills) in patients with Parkinson's disease.
- Published
- 2021
33. Multi-center observational study on occurrence and related clinical factors of neurogenic heterotopic ossification in patients with disorders of consciousness
- Author
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G P Salvi, Lucia Francesca Lucca, P Bongioanni, M Bertoni, S Gentile, S Premoselli, Michelangelo Bartolo, Rita Formisano, C Perin, Elena Rossato, E Casanova, M Gambarin, Orsola Masotta, Federico Scarponi, A. Pascarella, Domenico Intiso, Anna Estraneo, A De Tanti, R Antenucci, Valeria Pingue, Annamaria Romoli, Francesca Pistoia, Luigi Trojano, Silvia Marino, Antonino Sant'Angelo, A R Diana, Estraneo, A, Pascarella, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A M, Gentile, S, Formisano, R, Salvi, G P, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A R, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, Trojano, L, Romoli, A, Salvi, G, and Diana, A
- Subjects
030506 rehabilitation ,Pediatrics ,medicine.medical_specialty ,Heterotopic ossification ,disorders of consciousne ,Consciousness ,Cross-sectional study ,media_common.quotation_subject ,medicine.medical_treatment ,Neuroscience (miscellaneous) ,Disorders of consciousness ,Ossification ,vegetative state ,rehabilitation ,03 medical and health sciences ,0302 clinical medicine ,Developmental and Educational Psychology ,medicine ,Humans ,In patient ,disorders of consciousness ,minimally conscious state ,Consciousness Disorders ,Cross-Sectional Studies ,Persistent Vegetative State ,Ossification, Heterotopic ,media_common ,Rehabilitation ,business.industry ,Minimally conscious state ,medicine.disease ,MED/34 - MEDICINA FISICA E RIABILITATIVA ,Observational study ,Heterotopic ,Neurology (clinical) ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Aims: to assess occurrence and clinical correlates of neurogenic heterotopic ossifications (NHO) in patients with prolonged disorder of consciousness (DoC). Design: multi-center cross-sectional observational study. Setting: 23 intensive neurorehabilitation units. Subjects: 287 patients with prolonged disorder of consciousness (DoC; 150 in vegetative state, VS, and 128 in minimally conscious state, MCS) of different etiology (vascular=125, traumatic=83, anoxic=56, others=14). Main Measures: clinical evidence of NHO confirmed by standard radiological and/or sonographic evaluation; Coma Recovery Scale-Revised; Disability Rating Scale (DRS); Early Rehabilitation Barthel Index; presence of ventilator support, spasticity, bone fractures and paroxysmal sympathetic hyperactivity. Results: 31 patients (11.2%) presented NHO. Univariate analyses showed that NHO was associated with VS diagnosis, traumatic etiology, high DRS category and total score, and high occurrence of limb spasticity and bone fractures. A cluster-corrected binary logistic regression model (excluding spasticity available in a subset of patients) showed that only lower DRS total score and presence of bone fractures were independently associated with NHO. Conclusions: NHO are relatively frequent in patients with DoC, and are independently associated with functional disability, bone fractures and spasticity. These findings contribute to identifying patients with DoC prone to develop NHO and requiring special interventions to improve functional recovery.
- Published
- 2021
34. Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies
- Author
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G P Salvi, A R Diana, Valeria Pingue, Michelangelo Bartolo, Anna Estraneo, S Premoselli, F De Bellis, Rita Formisano, Domenico Intiso, R Antenucci, M Gambarin, Federico Scarponi, P Bongioanni, C Perin, A De Tanti, Orsola Masotta, Annamaria Romoli, Francesca Pistoia, S Gentile, Elena Rossato, Silvia Marino, Antonino Sant'Angelo, E Casanova, Lucia Francesca Lucca, M Bertoni, Estraneo, A, Masotta, O, Bartolo, M, Pistoia, F, Perin, C, Marino, S, Lucca, L, Pingue, V, Casanova, E, Romoli, A, Gentile, S, Formisano, R, Salvi, G, Scarponi, F, De Tanti, A, Bongioanni, P, Rossato, E, Santangelo, A, Diana, A, Gambarin, M, Intiso, D, Antenucci, R, Premoselli, S, Bertoni, M, and De Bellis, F
- Subjects
030506 rehabilitation ,medicine.medical_specialty ,Consciousness ,medicine.medical_treatment ,Neuroscience (miscellaneous) ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Developmental and Educational Psychology ,Medicine ,Humans ,clinical complexity ,Disorders of consciousne ,Neurorehabilitation ,Persistent vegetative state ,Coma ,Disorders of consciousness ,neurorehabilitation ,Rehabilitation ,business.industry ,Persistent Vegetative State ,Minimally conscious state ,medical complications ,outcome ,medical complication ,Disability Rating Scale ,medicine.disease ,Cross-Sectional Studies ,Brain Injuries ,Etiology ,Consciousness Disorders ,Wakefulness ,Neurology (clinical) ,medicine.symptom ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Aim: to assess overall clinical complexity of patients with acquired disorders of consciousness (DoC) in vegetative state/unresponsive wakefulness syndrome (VS/UWS) vs. minimally conscious state- MCS) and in different etiologies. Design: Multi-center cross-sectional observational study. Setting: 23 intensive neurorehabilitation units. Subjects: 264 patients with DoC in the post-acute phase: VS/UWS = 141, and MCS = 123 due to vascular (n = 125), traumatic (n = 83) or anoxic (n = 56) brain injury. Main Measures: Coma Recovery Scale-Revised, and Disability Rating Scale (DRS); presence of medical devices (e.g., for eating or breathing); occurrence and severity of medical complications. Results: patients in DoC, and particularly those in VS/UWS, showed severe overall clinical complexity. Anoxic patients had higher overall clinical complexity, lower level of responsiveness/consciousness, higher functional disability, and higher needs of medical devices. Vascular patients had worse premorbid clinical comorbidities. The two etiologies showed a comparable rate of MC, higher than that observed in traumatic etiology. Conclusion: overall clinical complexity is significantly higher in VS/UWS than in MCS, and in non-traumatic vs. traumatic etiology. These findings could explain the worse clinical evolution reported in anoxic and vascular etiologies and in VS/UWS patients and contribute to plan patient-tailored care and rehabilitation programmes.
- Published
- 2020
35. A Multi-Centric Observational Study on Heterotopic Ossification in Severely Brain-Injured Patients with Disorders of Consciousness: Preliminary Data
- Author
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Masotta, Orsola, Angelo Pascarella, Loreto, Vincenzo, Trojano, Luigi, Formisano, Rita, Bartol, Michelangelo, Aabid, Hend, Perin, Cecilia, Pistoia, Francesca, Sara, Marco, Nardone, Antonio, Berlusconi, Marta, Marino, Silvia, Lucca, Lucia, Gentile, Simona, Piperno, Roberto, Casanova, Emanuela, Romoli, Anna Maria, Scarponi, Federico, Patriarca, Elena, Carboncini, Maria Chiara, Avesani, Renato, Sant Angelo, Nino, Intiso, Domenico, Diana, Anna Rita, Pilia, Felicita, Salvi, Gian Pietro, Gambarin, Mattia, Premoselli, Silvia, Tanti, Antonio, Bertoni, Michele, Biacchi, Daniela, Antenucci, Roberto, Estraneo, Anna, Masotta, O, Pascarella, A, Loreto, V, Trojano, L, Formisano, R, Bartol, M, Aabid, H, Perin, C, Pistoia, F, Sara, M, Nardone, A, Berlusconi, M, Marino, S, Lucca, L, Gentile, S, Piperno, R, Casanova, E, Romoli, A, Scarponi, F, Patriarca, E, Carboncini, M, Avesani, R, Sant'Angelo, N, Intiso, D, Diana, A, Pilia, F, Salvi, G, Gambarin, M, Premoselli, S, De Tanti, A, Bertoni, M, Biacchi, D, Antenucci, R, and Estraneo, A
- Subjects
Brain Injury, Heterotopic ossification
36. Balance Rehabilitation through Robot-Assisted Gait Training in Post-Stroke Patients: A Systematic Review and Meta-Analysis.
- Author
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Loro A, Borg MB, Battaglia M, Amico AP, Antenucci R, Benanti P, Bertoni M, Bissolotti L, Boldrini P, Bonaiuti D, Bowman T, Capecci M, Castelli E, Cavalli L, Cinone N, Cosenza L, Di Censo R, Di Stefano G, Draicchio F, Falabella V, Filippetti M, Galeri S, Gimigliano F, Grigioni M, Invernizzi M, Jonsdottir J, Lentino C, Massai P, Mazzoleni S, Mazzon S, Molteni F, Morelli S, Morone G, Nardone A, Panzeri D, Petrarca M, Posteraro F, Santamato A, Scotti L, Senatore M, Spina S, Taglione E, Turchetti G, Varalta V, Picelli A, and Baricich A
- Abstract
Background: Balance impairment is a common disability in post-stroke survivors, leading to reduced mobility and increased fall risk. Robotic gait training (RAGT) is largely used, along with traditional training. There is, however, no strong evidence about RAGT superiority, especially on balance. This study aims to determine RAGT efficacy on balance of post-stroke survivors., Methods: PubMed, Cochrane Library, and PeDRO databases were investigated. Randomized clinical trials evaluating RAGT efficacy on post-stroke survivor balance with Berg Balance Scale (BBS) or Timed Up and Go test (TUG) were searched. Meta-regression analyses were performed, considering weekly sessions, single-session duration, and robotic device used., Results: A total of 18 trials have been included. BBS pre-post treatment mean difference is higher in RAGT-treated patients, with a pMD of 2.17 (95% CI 0.79; 3.55). TUG pre-post mean difference is in favor of RAGT, but not statistically, with a pMD of -0.62 (95%CI - 3.66; 2.43). Meta-regression analyses showed no relevant association, except for TUG and treatment duration (β = -1.019, 95% CI - 1.827; -0.210, p -value = 0.0135)., Conclusions: RAGT efficacy is equal to traditional therapy, while the combination of the two seems to lead to better outcomes than each individually performed. Robot-assisted balance training should be the focus of experimentation in the following years, given the great results in the first available trials. Given the massive heterogeneity of included patients, trials with more strict inclusion criteria (especially time from stroke) must be performed to finally define if and when RAGT is superior to traditional therapy.
- Published
- 2023
- Full Text
- View/download PDF
37. Effects of robot-assisted gait training on postural instability in Parkinson's disease: a systematic review.
- Author
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Picelli A, Capecci M, Filippetti M, Varalta V, Fonte C, DI Censo R, Zadra A, Chignola I, Scarpa S, Amico AP, Antenucci R, Baricich A, Benanti P, Bissolotti L, Boldrini P, Bonaiuti D, Castelli E, Cavalli L, DI Stefano G, Draicchio F, Falabella V, Galeri S, Gimigliano F, Grigioni M, Jonsdottir J, Lentino C, Massai P, Mazzoleni S, Mazzon S, Molteni F, Morelli S, Morone G, Panzeri D, Petrarca M, Posteraro F, Senatore M, Taglione E, Turchetti G, Bowman T, and Nardone A
- Subjects
- Gait Disorders, Neurologic physiopathology, Humans, Parkinson Disease physiopathology, Exoskeleton Device, Gait Disorders, Neurologic rehabilitation, Parkinson Disease rehabilitation, Postural Balance physiology, Robotics methods
- Abstract
Introduction: Postural instability is a cardinal feature of Parkinson's disease, together with rest tremor, rigidity and bradykinesia. It is a highly disabling symptom that becomes increasingly common with disease progression and represents a major source of reduced quality of life in patients with Parkinson's disease. Rehabilitation aims to enable patients with Parkinson's disease to maintain their maximum level of mobility, activity and independence. To date, a wide range of rehabilitation approaches has been employed to treat postural instability in Parkinson's disease, including robotic training. Our main aim was to conduct a systematic review of current literature about the effects of robot-assisted gait training on postural instability in patients with Parkinson's disease., Evidence Acquisition: A systematic search using the following MeSH terms "Parkinson disease," "postural balance," "robotics," "rehabilitation" AND string "robotics [mh]" OR "robot-assisted" OR "electromechanical" AND "rehabilitation [mh]" OR "training" AND "postural balance [mh]" was conducted on PubMed, Cochrane Library and Pedro electronic databases. Full text articles in English published up to December 2020 were included. Data about patient characteristics, robotic devices, treatment procedures and outcome measures were considered. Every included article got checked for quality. Level of evidence was defined for all studies., Evidence Synthesis: Three authors independently extracted and verified data. In total, 18 articles (2 systematic reviews, 9 randomized controlled trials, 4 uncontrolled studies and 3 case series/case reports) were included. Both end-effector and exoskeleton devices were investigated as to robot-assisted gait training modalities. No clear relationship between treatment parameters and clinical conditions was observed. We found a high level of evidence about the effects of robot-assisted gait training on balance and freezing of gait in patients with Parkinson's disease., Conclusions: This systematic review provides to the reader a complete overview of current literature and levels of evidence about the effects of robot-assisted gait training on postural instability issues (static and dynamic balance, freezing of gait, falls, confidence in activities of daily living and gait parameters related to balance skills) in patients with Parkinson's disease.
- Published
- 2021
- Full Text
- View/download PDF
38. What is the impact of robotic rehabilitation on balance and gait outcomes in people with multiple sclerosis? A systematic review of randomized control trials.
- Author
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Bowman T, Gervasoni E, Amico AP, Antenucci R, Benanti P, Boldrini P, Bonaiuti D, Burini A, Castelli E, Draicchio F, Falabella V, Galeri S, Gimigliano F, Grigioni M, Mazzon S, Mazzoleni S, Mestanza Mattos FG, Molteni F, Morone G, Petrarca M, Picelli A, Posteraro F, Senatore M, Turchetti G, Crea S, Cattaneo D, and Carrozza MC
- Subjects
- Combined Modality Therapy, Disability Evaluation, Humans, Randomized Controlled Trials as Topic, Walk Test, Exoskeleton Device, Gait Disorders, Neurologic rehabilitation, Multiple Sclerosis rehabilitation, Robotics methods
- Abstract
Introduction: In recent years, robot-assisted gait training (RAGT) has been proposed as therapy for balance and gait dysfunctions in people with multiple sclerosis (PwMS). Through this systematic review, we aimed to discuss the impact of RAGT on balance and gait outcomes. Furthermore, characteristics of the training in terms of robots used, participants characteristics, protocols and combined therapeutic approaches have been described., Evidence Acquisition: As part of the Italian Consensus on robotic rehabilitation "CICERONE" a systematic search was provided in PubMed, the Cochrane Library and PEDro to identify relevant studies published before December 2019. Only randomized control trials (RCT) involving RAGT for PwMS were included. PEDro scale was used to assess the risk of bias and the Oxford Center for Evidence-Based Medicine (OCEBM) was used to assess level of evidence of included studies., Evidence Synthesis: The search on databases resulted in 336 records and, finally, 12 studies were included. RAGT was provided with Exoskeleton in ten studies (6-40 session, 2-5 per week) and with end-effector in two studies (12 sessions, 2-3 per week) with large variability in terms of participants' disability. All the exoskeletons were combined with bodyweight support treadmill and movement assistance varied from 0% to 100% depending on participants' disability, two studies combined exoskeleton with virtual reality. The end-effector speed ranged between 1.3 and 1.8 km/h, with bodyweight support starting from 50% and progressively reduced. In seven out of twelve studies RAGT was provided in a multimodal rehabilitation program or in combination with standard physical therapy. There is level 2 evidence that RAGT has positive impact in PwMS, reaching the minimally clinically importance difference in Berg Balance Scale, six-minute walking test and gait speed., Conclusions: In available RCT, RAGT is mostly provided with exoskeleton devices and improves balance and gait outcomes in a clinically meaningful way. Considering several advantages in terms of safety, motor assistance and intensity of training provided, RAGT should be promoted for PwMS with severe disability in a multimodal rehabilitation context as an opportunity to maximize recovery.
- Published
- 2021
- Full Text
- View/download PDF
39. Diagnostic Accuracy of a Bedside Screening Tool for Dysphagia (BSTD) in Acute Stroke Patients.
- Author
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Immovilli P, Rota E, Morelli N, Marchesi E, Terracciano C, Zaino D, Ferrari G, Antenucci R, and Guidetti D
- Subjects
- Aged, Aged, 80 and over, Deglutition Disorders etiology, Deglutition Disorders physiopathology, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Stroke diagnosis, Stroke physiopathology, Deglutition, Deglutition Disorders diagnosis, Point-of-Care Testing, Stroke complications
- Abstract
Background and Purpose: an estimated 40-80% of acute ischemic stroke patients have dysphagia and about 14% develop stroke-associated pneumonia. However, it may be difficult to detect swallowing problems at admission. Moreover, there might not be an on-duty specialist skilled in the diagnosis of this condition. This study aimed at developing a user-friendly bedside examination to identify the risk of dysphagia in stroke patients at hospital admission., Methods: a diagnostic accuracy study was carried out to assess the concurrent validity of a simple Bedside Screening Tool for Dysphagia (BSTD) in acute stroke. All the consecutive stroke patients admitted between January and April 2018 were enrolled. Sensitivity, specificity, positive (PPV), negative predictive values (NPV) and the Cohen K concordance index scores, reported by nurses and speech-pathologists, were assessed., Results: a total of 67/120 patients (55.8%) were male; overall average age was 67.4 (range 45-91) and 80.8% of the whole population had a history of ischemic stroke. The nursing staff identified 33.3% of dysphagia cases at admission and the speech pathologists 30%. The Cohen K was 0.92 (optimal concordance when K was > 0.8), sensitivity was 100%, specificity 95.2%, PPV 90% and NPV 100%., Conclusions: our BSTD had a 100% negative predictive value, indicating that this screening test is very useful in ruling out/confirming dysphagia in acute stroke patients., Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest regarding the manuscript, (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
40. Multi-center study on overall clinical complexity of patients with prolonged disorders of consciousness of different etiologies.
- Author
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Estraneo A, Masotta O, Bartolo M, Pistoia F, Perin C, Marino S, Lucca L, Pingue V, Casanova E, Romoli A, Gentile S, Formisano R, Salvi GP, Scarponi F, De Tanti A, Bongioanni P, Rossato E, Santangelo A, Diana AR, Gambarin M, Intiso D, Antenucci R, Premoselli S, Bertoni M, and De Bellis F
- Subjects
- Consciousness Disorders etiology, Cross-Sectional Studies, Humans, Persistent Vegetative State etiology, Brain Injuries, Consciousness
- Abstract
Aim : to assess overall clinical complexity of patients with acquired disorders of consciousness (DoC) in vegetative state/unresponsive wakefulness syndrome (VS/UWS) vs. minimally conscious state- MCS) and in different etiologies.. Design: Multi-center cross-sectional observational study. Setting : 23 intensive neurorehabilitation units. Subjects : 264 patients with DoC in the post-acute phase: VS/UWS = 141, and MCS = 123 due to vascular (n = 125), traumatic (n = 83) or anoxic (n = 56) brain injury. Main Measures : Coma Recovery Scale-Revised, and Disability Rating Scale (DRS); presence of medical devices (e.g., for eating or breathing); occurrence and severity of medical complications. Results : patients in DoC, and particularly those in VS/UWS, showed severe overall clinical complexity. Anoxic patients had higher overall clinical complexity, lower level of responsiveness/consciousness, higher functional disability, and higher needs of medical devices. Vascular patients had worse premorbid clinical comorbidities. The two etiologies showed a comparable rate of MC, higher than that observed in traumatic etiology. Conclusion : overall clinical complexity is significantly higher in VS/UWS than in MCS, and in non-traumatic vs. traumatic etiology. These findings could explain the worse clinical evolution reported in anoxic and vascular etiologies and in VS/UWS patients and contribute to plan patient-tailored care and rehabilitation programmes.
- Published
- 2021
- Full Text
- View/download PDF
41. Early rehabilitation for severe acquired brain injury in intensive care unit: multicenter observational study.
- Author
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Bartolo M, Bargellesi S, Castioni CA, Bonaiuti D, Antenucci R, Benedetti A, Capuzzo V, Gamna F, Radeschi G, Citerio G, Colombo C, Del Casale L, Recubini E, Toska S, Zanello M, D'Aurizio C, Spina T, Del Gaudio A, Di Rienzo F, Intiso D, Dallocchio G, Felisatti G, Lavezzi S, Zoppellari R, Gariboldi V, Lorini L, Melizza G, Molinero G, Mandalà G, Pignataro A, Montis A, Napoleone A, Pilia F, Pisu M, Semerjian M, Pagliaro G, Nardin L, Scarponi F, Zampolini M, Zava R, Massetti MA, Piccolini C, Aloj F, Antonelli S, and Zucchella C
- Subjects
- Aged, Brain Injuries etiology, Brain Injuries physiopathology, Critical Care, Female, Glasgow Coma Scale, Hospitalization, Humans, Italy, Male, Middle Aged, Prospective Studies, Recovery of Function, Treatment Outcome, Brain Injuries rehabilitation, Intensive Care Units
- Abstract
Background: The increased survival after a severe acquired brain injury (sABI) raise the problem of making most effective the treatments in Intensive Care Unit (ICU)/Neurointensive Care Unit (NICU), also integrating rehabilitation care. Despite previous studies reported that early mobilization in ICU was effective in preventing complications and reducing hospital stay, few studies addressed the rehabilitative management of sABI patients in ICU/NICU., Aim: To collect clinical and functional data about the early rehabilitative management of sABI patients during ICU/NICU stay., Design: Prospective, observational, multicenter study., Setting: Fourteen facilities supplied by intensive neurorehabilitation units and ICU/NICUs., Population: Consecutive sABI patients admitted to ICU/NICU., Methods: Patients were evaluated at admission and then every 3-5 days. Clinical, functional and rehabilitative data, including Glasgow Coma Scale (GCS), Disability Rating Scale (DRS), The Rancho Los Amigos Levels of Cognitive Functioning Scale (LCF), Early Rehabilitation Barthel Index (ERBI), Glasgow Outcome scale (GOS) and Functional Independence Measure (FIM) were collected., Results: One hundred and two patients (F/M 44/58) were enrolled. The mean duration of ICU stay was 24.7±13.9 days and the first rehabilitative evaluation occurred after 8.7±8.8 days. Regular postural changes and multijoint mobilization were prescribed in 63.7% and 64.7% cases, respectively. The mean session duration was 38±11.5 minutes. Swallowing evaluation was performed in 14.7% patients, psychological support was provided to 12.7% of patients' caregivers, while 17.6% received a psycho-educational intervention, and 28.4% were involved in interdisciplinary team meetings. The main discharge destinations were Severe Acquired Brain Injury rehabilitation units for 43.7%, intensive neurorehabilitation units for 20.7%., Conclusions: Data showed that early rehabilitation was not diffusely performed in sABI subjects in ICU/NICU and rehabilitative interventions were variable; one-third of subjects were not referred to dedicated rehabilitation unit at discharge., Clinical Rehabilitation Impact: The study stresses the need to spread and implement a rehabilitative culture also for critical ill patients due to neurological diseases.
- Published
- 2016
42. Lung cancer presenting as a metastasis to the carpal bones: a case report.
- Author
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Rinonapoli G, Caraffa A, and Antenucci R
- Abstract
Introduction: A first metastasis to the hand is extremely rare. Usually, an acrometastasis is a sign of very advanced disease, with the presence of previous multiple metastases elsewhere. The present paper is one of the very few case reports of first metastatic location to carpal bones. To date, only Lederer et al., in 1990, and Song and Yao in 2012, have described a metastasis to the trapezium from lung cancer., Case Presentation: A 74-year-old Caucasian man was submitted to several physical examinations for thumb pain. The first diagnosis was tendonitis and the second diagnosis was thumb carpometacarpal osteoarthritis. Only when the patient was admitted to an internal medicine department for deterioration of his general condition and an enormous mass on his left hand was an open biopsy performed. It revealed a metastasis from large-cell lung carcinoma. A total-body scintigraphy and total-body computed tomography scan were negative for other secondary locations. The patient underwent an amputation at the distal third of the forearm., Conclusion: Less than 20 case reports are available in the literature dealing with metastases to carpal bones. Very few cases are described as carpal metastases in the absence of other previous metastases, and only two articles, before the present one, have reported a metastasis to the trapezium. This case report teaches us two things: first, patient adherence to follow-up is extremely important; and, second, a thorough examination of diagnostic findings needs to be carried out at all times.
- Published
- 2012
- Full Text
- View/download PDF
43. Cardiorespiratory comorbidity: a new challenge for physical and rehabilitation medicine specialist.
- Author
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Massucci M, Perrero L, Mantellini E, Petrozzino S, Gamna F, Nocella A, Sciarrini F, Antenucci R, and Bonaiuti D
- Subjects
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Comorbidity trends, Female, Heart Diseases rehabilitation, Humans, Italy epidemiology, Male, Middle Aged, Respiratory Tract Diseases rehabilitation, Retrospective Studies, Workforce, Disability Evaluation, Heart Diseases epidemiology, Length of Stay statistics & numerical data, Outcome Assessment, Health Care, Patient Discharge statistics & numerical data, Rehabilitation Centers, Respiratory Tract Diseases epidemiology
- Abstract
Background: The cardiorespiratory comorbidity can reduce the participation in the rehabilitation project of patients with motor disorders., Aim: The first aim of the study was to assess the frequency of cardiopulmonary comorbidity in inpatient rehabilitation units in Italy. The second aim was to evaluate the influence of cardiorespiratory comorbidity on some process and outcome indicators., Design: Data collection with a questionnaire sent to Physical and Rehabilitation Medicine specialists., Setting: Inpatient Rehabilitation Units., Population: Patients admitted to Rehabilitation Units with neurological and orthopedic disability., Methods: A questionnaire was sent to 33 Rehabilitation Units in Italy., Outcome: Length of stay in hospital (LOS), percentage of transfer to acute wards, level of satisfaction of the Physicians related to the degree of functional recovery of patients with cardiopulmonary comorbidity. In a subgroup of patients with and without cardiopulmonary comorbidity indicators were also used to retrospectively assess functional recovery during the hospitalization., Results: Analysis were made on 16 complete responses received. Data of 909 subjects were evaluated. The mean incidence of cardiovascular and respiratory diseases is high: 61.50%. The length of hospitalization (LOS) in patients with cardiac and respiratory comorbidity is significantly longer than in subjects without associated disease (46.55, SD 21.00 days vs. 37.26, SD 18.97; P<0.05). The number of transfers to acute wards is significantly higher in subjects with cardiorespiratory comorbidity (8.62% vs. 2.44%; P<0.05). Eleven out of 16 medical doctors (69%) said they were "quite satisfied" for the degree of functional recovery of patients with comorbidity. A group of patients with neurological disabilities associated with cardiorespiratory disease had significantly lower Functional Independence Measure (FIM) score at admission (55.36, SD 20.62, vs. 73.72, SD 22.15; P<0.05) than these without comorbidity. At discharge the subjects of the two groups assessed, independently from the presence of cardiorespiratory comorbidity, present no statistically significant difference of FIM scale values., Conclusion: The high frequency of cardiorespiratory comorbidity in patients with motor disorders negatively influenced the LOS and percentage of transfer to acute wards but not necessarily the functional results. It is, therefore, necessary to train the medical doctor who specializes in physical and rehabilitation medicine also in the clinical management of complex patients., Clinical Rehabilitation Impact: The results of the survey suggest that rehabilitation is useful even in patients with motor disorders and cardiorespiratory comordibity.
- Published
- 2012
44. Effect of aerobic training on walking capacity and maximal exercise tolerance in patients with multiple sclerosis: a randomized crossover controlled study.
- Author
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Rampello A, Franceschini M, Piepoli M, Antenucci R, Lenti G, Olivieri D, and Chetta A
- Subjects
- Adult, Cross-Over Studies, Female, Heart Rate physiology, Humans, Male, Mental Health, Multiple Sclerosis physiopathology, Multiple Sclerosis psychology, Oximetry, Oxygen Consumption physiology, Quality of Life, Respiratory Function Tests, Surveys and Questionnaires, Exercise physiology, Exercise Tolerance physiology, Multiple Sclerosis rehabilitation, Walking physiology
- Abstract
Background and Purpose: Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity-in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life-as compared with neurological rehabilitation (NR) in subjects with MS., Subjects and Methods: Nineteen subjects (14 female, 5 male; mean age [X+/-SD]=41+/-8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [X+/-SD]=44+/-6 years) completed the study., Results: After AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life., Discussion and Conclusion: The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
- Published
- 2007
- Full Text
- View/download PDF
45. Turkey red blood cell passive haemagglutination assay as guideline for specific prevention of tetanus in injured persons.
- Author
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Bistoni F, Marconi P, Perito S, Bastianini L, Antenucci R, and Pitzurra M
- Subjects
- Animals, Antibodies, Bacterial analysis, Clostridium tetani immunology, Enzyme-Linked Immunosorbent Assay, Hemagglutination Tests, Humans, Turkeys, Erythrocytes immunology, Tetanus prevention & control
- Abstract
Turkey red blood cell passive haemagglutination assays (TRBC-HA) were carried out on serum samples from 873 injured patients in order to compare individual prophylactic treatment against tetanus based on the anti-tetanus antibody levels with interventions based on anamnestic criteria. The results showed a great difference: according to the anamnesis 124 persons (14.2%) were protected, 253 (29%) were partially protected, and 496 (56.8%) were unprotected; according to the TRBC-HA assay, 479 (54.9%) were protected, 279 (32%) partially protected, and 115 (13.2%) unprotected.The efficiency of the prophylactic treatments given on the basis of the two criteria was also compared in a study of 129 injured patients who were divided in two groups: group 1 (50 patients) received 250 IU of human tetanus immunoglobulin (HTI) regardless of their tetanus immunity, and group II (79 patients) received appropriate or no treatment depending on the level of anti-tetanus antibodies determined by TRBC-HA assay. The results showed that prophylactic interventions based on the anti-tetanus antibody levels can give protection in 100% of injured patients at minimum cost and risk.
- Published
- 1985
46. Long-term results of conservative treatment of fractures of the distal radius.
- Author
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Altissimi M, Antenucci R, Fiacca C, and Mancini GB
- Subjects
- Adolescent, Adult, Aged, Carpal Tunnel Syndrome etiology, Casts, Surgical, Colles' Fracture complications, Colles' Fracture diagnostic imaging, Female, Follow-Up Studies, Fracture Fixation, Humans, Male, Manipulation, Orthopedic, Middle Aged, Nerve Compression Syndromes etiology, Pain etiology, Radiography, Time Factors, Traction, Ulnar Nerve, Colles' Fracture therapy, Radius Fractures therapy
- Abstract
The long-term results of the conservative treatment of wrist fractures were observed in a follow-up study of 297 cases over a period of one and one-half years to six years. The evaluation of the results was based on clinical parameters, both subjective and objective, as well as radiological features. The results were: excellent in 38% of cases, good in 49%, fair in 11.5%, and poor in 1.5%; considerably worse were the subjective results (20% fair to poor). No statistically significant relation could be found between results and type of fracture. Clinical deformities and pain in the area of the distal radioulnar joint were frequent. Decrease in grip strength was observed in 17.8% of cases. A limitation of wrist movement was not frequent. Numerous compressive neuropathies were found (41 in 35 patients), especially of the median nerve. The values relative to the three radiographic parameters under investigation (that is, radial deviation, volar tilt, and radioulnar index) were often found to be out of the normal range. The comparative study of postreduction and follow-up radiograms show the loss of reduction to be frequent, especially as far as the volar tilt is concerned. The frequent radiologic deformities are associated with significantly bad results only in cases of extremely abnormal values. However, fractures of the distal radius are not to be underestimated. Long-term results following conservative treatment may not be as acceptable as is generally assumed.
- Published
- 1986
47. Stable fixation of fractures of the forearm in adults.
- Author
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Pecorelli F, Della Torre P, and Antenucci R
- Subjects
- Adolescent, Adult, Aged, Bone Screws, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Radiography, Radius Fractures complications, Radius Fractures diagnostic imaging, Time Factors, Ulna Fractures complications, Ulna Fractures diagnostic imaging, Bone Plates, Radius Fractures surgery, Ulna Fractures surgery
- Abstract
The results are presented of 148 fractures of the radius and ulna in 89 patients. All were treated by AO compression plating. The results were assessed at an average of 4.5 years. In 80% of cases these were functionally excellent and confirm that this method of treatment gives early consolidation and restoration of good function in adults. However, there is a significant percentage of complications in open fractures of both bones.
- Published
- 1985
48. [Femoral neck fractures in young adults (review of 29 cases)].
- Author
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Cerulli G and Antenucci R
- Subjects
- Adult, Bone Nails, Female, Humans, Male, Osteonecrosis etiology, Postoperative Complications, Pseudarthrosis etiology, Femoral Neck Fractures surgery, Fracture Fixation, Intramedullary
- Published
- 1981
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