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1. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Author

Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., and Vitols, A.

Abstract

The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1,415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, −0.1 to 0.2] kg/m2) and neck circumference (0.0 (95% confidence interval, −0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non-obese (body mass index <30 kg/m2) patients, positive airway pressure treatment was associated with an increased body mass index and waist circumference (0.4 [0.3–0.5] kg/m2 and 0.8 [0.4–1.2] cm, respectively, all p < 0.05), and weight gain was significantly associated with higher positive airway pressure compliance and longer positive airway pressure treatment duration. In the obese subgroup, body mass index was reduced after positive airway pressure treatment (−0.3 [−0.5 to −0.1] kg/m2, p < 0.05) mainly in patients with a strong reduction in Epworth Sleepiness Scale. In conclusion, positive airway pressure therapy was not found to systematically change body mass index in the European Sleep Apnea Database cohort, but the response was heterogeneous. Our findings suggest that weight gain may be restricted to an obstructive sleep apnea phenotype without established obesity. Lifestyle intervention needs to be considered in both lean and obese patients with obstructive slee

Published
2018

2. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Author

Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L, ESADA Study Group., ESADA Study Grp, Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, and Vitols, A

Subjects
Data Analysis, Male, Time Factors, Excessive daytime sleepiness, Weight Gain, excessive daytime sleepine, Body Mass Index, Cohort Studies, Behavioral Neuroscience, 0302 clinical medicine, Positive airway pressure, Medicine, Longitudinal Studies, Prospective Studies, obstructive sleep apnea, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Epworth Sleepiness Scale, Sleep apnea, General Medicine, Middle Aged, weight, central obesity, positive airway pressure, ESADA cohort, Europe, Obesity, Abdominal, Cardiology, Female, Waist Circumference, medicine.symptom, Adult, medicine.medical_specialty, Cognitive Neuroscience, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Internal medicine, Humans, Aged, business.industry, Body Weight, body weight, central obesity, excessive daytime sleepiness, obstructive sleep apnea, positive airway pressure, ta3121, medicine.disease, Obesity, respiratory tract diseases, Obstructive sleep apnea, 030228 respiratory system, Human medicine, business, Body mass index, Weight gain, 030217 neurology & neurosurgery
Abstract

The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, −0.1 to 0.2] kg/m2) and neck circumference (0.0 (95% confidence interval, −0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non- obese (body mass index

Published
2018

3. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort.

Author

Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, and Grote L

Subjects
Adult, Aged, Body Mass Index, Cohort Studies, Continuous Positive Airway Pressure methods, Data Analysis, Europe epidemiology, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Abdominal diagnosis, Prospective Studies, Sleep Apnea, Obstructive diagnosis, Time Factors, Waist Circumference physiology, Weight Gain physiology, Body Weight physiology, Continuous Positive Airway Pressure trends, Obesity, Abdominal epidemiology, Obesity, Abdominal therapy, Sleep Apnea, Obstructive epidemiology, Sleep Apnea, Obstructive therapy
Abstract

The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1,415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m 2 , apnea-hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, -0.1 to 0.2] kg/m 2 ) and neck circumference (0.0 (95% confidence interval, -0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non-obese (body mass index <30 kg/m 2 ) patients, positive airway pressure treatment was associated with an increased body mass index and waist circumference (0.4 [0.3-0.5] kg/m 2 and 0.8 [0.4-1.2] cm, respectively, all p < 0.05), and weight gain was significantly associated with higher positive airway pressure compliance and longer positive airway pressure treatment duration. In the obese subgroup, body mass index was reduced after positive airway pressure treatment (-0.3 [-0.5 to -0.1] kg/m 2 , p < 0.05) mainly in patients with a strong reduction in Epworth Sleepiness Scale. In conclusion, positive airway pressure therapy was not found to systematically change body mass index in the European Sleep Apnea Database cohort, but the response was heterogeneous. Our findings suggest that weight gain may be restricted to an obstructive sleep apnea phenotype without established obesity. Lifestyle intervention needs to be considered in both lean and obese patients with obstructive sleep apnea receiving positive airway pressure treatment., (© 2018 European Sleep Research Society.)

Published
2018
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