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3 results on '"Antônio C. Freitas"'

1. Lack of detection of human papillomavirus DNA in prostate carcinomas in patients from northeastern Brazil

Author

Ari P. Araujo-Neto, Hygor Ferreira-Fernandes, Carolina M.M. Amaral, Lina G. Santos, Antônio C. Freitas, Jacinto C. Silva-Neto, Juan A. Rey, Rommel R. Burbano, Benedito B. da Silva, France K.N. Yoshioka, and Giovanny R. Pinto

Subjects
human papillomavirus, prostate cancer, prevalence, HPV PCR detection, molecular epidemiology, Genetics, QH426-470
Abstract

Abstract Prostate cancer is the second most common cancer among men in western populations, and despite its high mortality, its etiology remains unknown. Inflammatory processes are related to the etiology of various types of tumors, and prostate inflammation, in particular, has been associated with prostate cancer carcinogenesis and progression. Human papillomavirus (HPV) is associated with benign and malignant lesions in the anogenital tract of both females and males. The possible role of HPV in prostate carcinogenesis is a subject of great controversy. In this study, we aimed to examine the prevalence of HPV infections in prostate carcinomas of patients from northeastern Brazil. This study included 104 tissue samples from primary prostate carcinoma cases. HPV DNA was purified and then amplified using MY09/11 and GP5+/GP6+ degenerate primer sets that detect a wide range of HPV types, and with specific PCR primers sets for E6 and E7 HPV regions to detect HPV 16. None of the samples showed amplification products of HPV DNA for primer sets MY09/11 and GP5+/GP6+, or the specific primer set for the E6 and E7 HPV regions. HPV infection, thus, does not seem to be one of the causes of prostate cancer in the population studied.

Published
2016
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2. New strategy for liquefying corn stover pellets

Author

dos Santos, Antonio C. Freitas, Overton, Jonathan C., Szeto, Ryan, Patel, Maulik H., Gutierrez, Diana M.R., Eby, Clark, Martínez Moreno, Ana M., Erk, Kendra A., Aston, John E., Thompson, David N., Dooley, James H., Sharma, Pankaj, Mosier, Nathan S., Ximenes, Eduardo, and Ladisch, Michael R.

Published
2021
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3. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner

Author

Jacky Bernard, Antônio C. Freitas, Jean-Yves Blay, Caroline Flament, Orianne Wagner-Ballon, Laurence Zitvogel, Cédric Ménard, A. Lecesne, Magali Terme, T. Tursz, Caroline Robert, Bernard Escudier, William Vainchencker, Eric Vivier, Claude Capron, Julien Taieb, Sophie Caillat-Zucman, François Ghiringhelli, Sophie Novault, Nathalie Chaput, Pierre E. Puig, François Martin, Rôle des cellules dendritiques dans la régulation des effecteurs de l'immunité antitumorale, Institut Gustave Roussy ( IGR ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Mort cellulaire et cancer, Université de Bourgogne ( UB ) -IFR100 - Structure fédérative de recherche Santé-STIC-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hematopoïèse et Cellules Souches ( U362 ), Centre d'Immunologie de Marseille - Luminy ( CIML ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Jean Godineau, Etablissement Français du Sang, Immunologie, génétique et traitement des maladies métaboliques et du diabète ( UMR_S 561 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ), Biologie des Populations Lymphocytaires, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bourgogne (UB)-IFR100 - Structure fédérative de recherche Santé-STIC-Institut National de la Santé et de la Recherche Médicale (INSERM), Hematopoïèse et Cellules Souches (U362), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Immunologie, génétique et traitement des maladies métaboliques et du diabète (UMR_S 561), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
MESH : Cytokines, MESH: Flow Cytometry, MESH : Immunity, Natural, MESH: T-Ly, Lymphocyte Activation, T-Lymphocytes, Regulatory, Mice, Interleukin 21, 0302 clinical medicine, T-Lymphocyte Subsets, Transforming Growth Factor beta, Neoplasms, MESH : Receptors, Immunologic, MESH : Cell Proliferation, Immunology and Allergy, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, MESH: Animals, MESH: Neoplasms, IL-2 receptor, Receptors, Immunologic, 0303 health sciences, MESH: Cytokines, hemic and immune systems, Flow Cytometry, Natural killer T cell, 3. Good health, Cell biology, Killer Cells, Natural, medicine.anatomical_structure, NK Cell Lectin-Like Receptor Subfamily K, Interleukin 12, Cytokines, Receptors, Natural Killer Cell, [SDV.IMM]Life Sciences [q-bio]/Immunology, France, MESH : Killer Cells, Natural, MESH : Cytotoxicity Tests, Immunologic, MESH: Killer Cells, Natural, MESH: Cell Line, Tumor, MESH : Flow Cytometry, Immunology, chemical and pharmacologic phenomena, MESH: Cytotoxicity Tests, Immunologic, MESH : Mice, Inbred C57BL, Biology, Article, Natural killer cell, 03 medical and health sciences, MESH: Mice, Inbred C57BL, Cell Line, Tumor, MESH: Cell Proliferation, MESH : Mice, medicine, Animals, Humans, Antigen-presenting cell, MESH: Lymphocyte Activation, MESH : France, MESH: Mice, MESH: Receptors, Immunologic, MESH : Lymphocyte Activation, Cell Proliferation, 030304 developmental biology, MESH: Immunity, Natural, Lymphokine-activated killer cell, MESH: Humans, MESH : Cell Line, Tumor, MESH : Humans, Cytotoxicity Tests, Immunologic, NKG2D, MESH : T-Ly, MESH : Neoplasms, Immunity, Innate, Mice, Inbred C57BL, MESH: France, MESH : Animals, 030215 immunology
Abstract

Tumor growth promotes the expansion of CD4+CD25+ regulatory T (T reg) cells that counteract T cell–mediated immune responses. An inverse correlation between natural killer (NK) cell activation and T reg cell expansion in tumor-bearing patients, shown here, prompted us to address the role of T reg cells in controlling innate antitumor immunity. Our experiments indicate that human T reg cells expressed membrane-bound transforming growth factor (TGF)–β, which directly inhibited NK cell effector functions and down-regulated NKG2D receptors on the NK cell surface. Adoptive transfer of wild-type T reg cells but not TGF-β−/− T reg cells into nude mice suppressed NK cell–mediated cytotoxicity, reduced NKG2D receptor expression, and accelerated the growth of tumors that are normally controlled by NK cells. Conversely, the depletion of mouse T reg cells exacerbated NK cell proliferation and cytotoxicity in vivo. Human NK cell–mediated tumor recognition could also be restored by depletion of T reg cells from tumor-infiltrating lymphocytes. These findings support a role for T reg cells in blunting the NK cell arm of the innate immune system.

Published
2007
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