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2. Can we rewire criminal mind via non-invasive brain stimulation of prefrontal cortex? Insights from clinical, forensic and social cognition studies

Author

Anselmo, Anna, Lucifora, Chiara, Rusconi, Patrice, Martino, Gabriella, Craparo, Giuseppe, Salehinejad, Mohammad A., and Vicario, Carmelo M.

Subjects
Prefrontal cortex -- Health aspects, Criminals -- Psychological aspects -- Health aspects, Brain stimulation -- Methods, Psychology and mental health
Abstract

Non-compliance with social and legal norms and regulations represents a high burden for society. Social cognition deficits are frequently called into question to explain criminal violence and rule violations in individuals diagnosed with antisocial personality disorder (APD), borderline personality disorder (BPD), and psychopathy. In this article, we proposed to consider the potential benefits of non-invasive brain stimulation (NIBS) to rehabilitate forensic population. We focused on the effects of NIBS of the prefrontal cortex, which is central in social cognition, in modulating aggression and impulsivity in clinical disorders, as well as in forensic population. We also addressed the effect of NIBS on empathy, and theory of mind in non-clinical and/or prison population. The reviewed data provide promising evidence on the beneficial effect of NIBS on aggression/impulsivity dyscontrol and social cognitive functions, suggesting its relevance in promoting reintegration of criminals into society., Author(s): Anna Anselmo [sup.1] , Chiara Lucifora [sup.2] , Patrice Rusconi [sup.1] , Gabriella Martino [sup.3] , Giuseppe Craparo [sup.4] , Mohammad A. Salehinejad [sup.5] , Carmelo M. Vicario [sup.1] [...]

Published
2023
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4. A Systematic Review on the Neuropsychological Assessment of Patients with LBP: The Impact of Chronic Pain on Quality of Life.

Author

Anselmo, Anna, Pagano, Maria, Cappadona, Irene, Cardile, Davide, Russo, Fabrizio, Laudisio, Alice, Papalia, Giuseppe Francesco, Quartarone, Angelo, Calabrò, Rocco Salvatore, and Corallo, Francesco

Subjects
*CHRONIC pain, *LUMBAR pain, *QUALITY of life measurement, *PAIN measurement, *QUALITY of life
Abstract

Background and objective: Low back pain (LBP) is most common pain syndrome in Europe, affecting approximately 50% of European citizens. LBP is a complex condition that negatively affects many aspects of an individual's life such as work productivity, mobility, and mental health. The aim of this study is to assess the impact of pain associated with chronic LBP on patients' quality of life. Methods: Clinical studies reviewed in our search with no time restrictions were identified from PubMed, Web of Science, Scopus, and Cochrane Library databases. Of the initial 1929 studies, only 15 met inclusion criteria. Results: Results of our study indicate that chronic pain has a negative impact on numerous functions and areas in which the individual is involved and that this condition leads to reduced performance. Conclusions: LBP is a debilitating condition for patients, negatively affecting quality of life. Future studies should focus on validating a standardized assessment that examines all aspects affected by LBP through a customized questionnaire. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Artificial Intelligence and Heart-Brain Connections: A Narrative Review on Algorithms Utilization in Clinical Practice.

Author

Micali, Giuseppe, Corallo, Francesco, Pagano, Maria, Giambò, Fabio Mauro, Duca, Antonio, D'Aleo, Piercataldo, Anselmo, Anna, Bramanti, Alessia, Garofano, Marina, Mazzon, Emanuela, Bramanti, Placido, and Cappadona, Irene

Subjects
ATRIAL fibrillation diagnosis, MEDICAL information storage & retrieval systems, RANDOM forest algorithms, CARDIOLOGY, RESEARCH funding, ARTIFICIAL intelligence, LOGISTIC regression analysis, RESEARCH evaluation, MEDLINE, SUPPORT vector machines, NEUROLOGY, MEDICAL databases, ARTIFICIAL neural networks, ONLINE information services, MACHINE learning, ALGORITHMS
Abstract

Cardiovascular and neurological diseases are a major cause of mortality and morbidity worldwide. Such diseases require careful monitoring to effectively manage their progression. Artificial intelligence (AI) offers valuable tools for this purpose through its ability to analyse data and identify predictive patterns. This review evaluated the application of AI in cardiac and neurological diseases for their clinical impact on the general population. We reviewed studies on the application of AI in the neurological and cardiological fields. Our search was performed on the PubMed, Web of Science, Embase and Cochrane library databases. Of the initial 5862 studies, 23 studies met the inclusion criteria. The studies showed that the most commonly used algorithms in these clinical fields are Random Forest and Artificial Neural Network, followed by logistic regression and Support-Vector Machines. In addition, an ECG-AI algorithm based on convolutional neural networks has been developed and has been widely used in several studies for the detection of atrial fibrillation with good accuracy. AI has great potential to support physicians in interpretation, diagnosis, risk assessment and disease management. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Optimisation of Remote Monitoring Programmes in Heart Failure: Evaluation of Patient Drop-Out Behaviour and Healthcare Professionals' Perspectives.

Author

Pagano, Maria, Corallo, Francesco, Anselmo, Anna, Giambò, Fabio Mauro, Micali, Giuseppe, Duca, Antonio, D'Aleo, Piercataldo, Bramanti, Alessia, Garofano, Marina, Bramanti, Placido, and Cappadona, Irene

Subjects
BEHAVIORAL assessment, SCALE analysis (Psychology), HEALTH services accessibility, RESEARCH funding, MEDICAL technology, INTERVIEWING, SOCIOECONOMIC factors, HEART failure, POPULATION geography, AGE distribution, ANXIETY, TELEMEDICINE, MEDICAL consultation, ATTITUDES of medical personnel, RESEARCH methodology, PATIENT-professional relations, PATIENT satisfaction, SOCIAL support, CARDIAC rehabilitation, MENTAL depression
Abstract

Heart failure (HF) is a growing epidemic, affecting millions of people worldwide, and is a major cause of mortality, morbidity, and impaired quality of life. Traditional cardiac rehabilitation is a valuable approach to the physical and quality-of-life recovery of patients with cardiovascular disease. The innovative approach of remote monitoring through telemedicine offers a solution based on modern technologies, enabling continuous collection of health data outside the hospital environment. Remote monitoring devices present challenges that could adversely affect patient adherence, resulting in the risk of dropout. By applying a cognitive-behavioral model, we aim to identify the antecedents of dropout behavior among patients adhering to traditional cardiac rehabilitation programs and remote monitoring in order to improve the latter. Our study was conducted from October 2023 to January 2024. In the first stage, we used data from literature consultation. Subsequently, data were collected from the direct experience of 49 health workers related to both remote monitoring and traditional treatment, recruited from the authors' workplace. Results indicate that patients with cardiovascular disease tend to abandon remote monitoring programs more frequently than traditional cardiac rehabilitation therapies. It is critical to design approaches that take these barriers into account to improve adherence and patient satisfaction. This analysis identified specific antecedents to address, helping to improve current monitoring models. This is crucial to promote care continuity and to achieve self-management by patients in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Genome analysis ofLegionella pneumophilaST901 an Italian endemic strain

Author

Ricci, Maria Luisa, primary, Fillo, Silvia, additional, Giordani, Francesco, additional, Ciammaruconi, Andrea, additional, Girolamo, Antonietta, additional, Anselmo, Anna, additional, Monte, Anella, additional, Cusimano, Valerio, additional, Caporali, Maria Grazia, additional, Rota, Maria Cristina, additional, Petzol, Markus, additional, Afshar, Baharak, additional, Lista, Florigio, additional, Luck, Christian, additional, and Scaturro, Maria, additional

Published
2023
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13. How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

Author

Siragusa, L., Angelico, R., Angrisani, M., Zampogna, B., Materazzo, M., Sorge, R., Giordano, Lucia, Meniconi, R., Coppola, A., Marino, A., Giraudo, G., Esposito, S., Urbani, A., De Pastena, M., Mastrapasqua, R., Garancini, M., Frontal, A., Pascal, G., Martellucc, J., Falb, F., Boscarelli, A., Bertoglio, P., Trecca, E., Galassi, L., Vento, V., Chiappini, A., Antonelli, A., Bennardo, F., Familiari, F., Giannaccare, G., Zappia, A. S., Giuliani, G., Falcone, F., Sebastiani, S., Montuori, M., Rossi, S., Sagnotta, A., Giuliani, B., Imbriani, G. C., Restaino, S., Andreani, L., Di Maria, F., Lagana, A. S., Vitiello, L., Berton, F., Virgilio, E., Palisi, M., Portigliotti, L., Calussi, M., Conti, L., Mauriello, C., Barone, Alessia Maria Addolorata, Saladino, E., Giaquinta, A., Zerb, D., Frazzetta, G., Merola, G., Chierici, A., Bini, R., Centonze, L., De Carlis, R., Ferrario, L., Giani, A., Lauterio, A., Tamini, N., Corti, Serafino, Botteri, E., Andreuccetti, J., D'Alessio, R., Cestaro, G., Clarizia, G., Spolini, A., Carboni, A. S., Benzoni, E., Galiffa, G., Perotti, B., Veroux, M., Randazzo, V., Topa, D., Pranteda, C., Contini, G., Iacusso, C., Voglino, V., Vita, P., Carrano, F. M., Ambrosio, L., Cammarata, R., Capolupo, G. T., Caputo, D., Carannante, F., Cascone, C., Esperto, F., Farolfi, T., Frasca, L., Gallo, I. F., Gibin, G., Giurazza, G., Improta, L., La Vaccara, V., Luffarelli, P., Luvero, D., Marangi, Giuseppe, Masciana, G., Mazzola, A., Mazzotta, E., Miligi, C. I., Montelione, N., Nenna, A., Orsaria, P., Papalia, R., Papalia, G. F., Parisi, F. R., Prata, F., Salzillo, R., Santini, Stefano Angelo, Sofo, F., Zampoli, A., Tanda, C., Altieri, G., Ardito, Francesco, Belia, Francesco, Bianchi, V., Biondi, Alberto, Brisinda, Giuseppe, Chiappetta, M., Ciolli, G., Ciolli, Alessandro, Ferracci, Federica, Ferri, L., Fico, V., Fiorillo, Claudio, Fransvea, Pietro, Galiandro, F., Giovinazzo, F., La Greca, Antonio, Litta, Francesco, Mele, C., Pafundi, D. P., Panettieri, Elena, Papa, Valerio, Patini, Romeo, Perrotta, Generoso, Puccioni, Caterina, Santocchi, P., Armatura, G., Olmi, S., Casoni Pattacini, G., Salgarello, S., Trompetto, M., Bombardini, C., La Rocca, R., Celentano, G., Micalef, A., Mazzella, A., Settembrini, A., Zoia, C., Degrate, L., Musumeci, Giampaolo, Palopoli, C. A. M., Montori, G., Bonati, E., Dinuzzi, V. P., Velluti, F., Balla, A., Bonasia, D. E., Coletta, D., Berardi, Giulia, Colasanti, M., Ferretti, Serena, Gasparoli, C., Mariano, Giuseppantonio, Avenia, S., Cianci, P., Cestino, L., Festa, F., Fazio, F., Ascari, F., Desio, M., Arroyo Murillo, G. A., Cereda, M., Galleano, R., David, G., Pansini, A., Gazia, C., Atzori, G., Desideri, L. F., Famularo, S., Galvanin, J., Giudici, V. M., Mangiameli, Gaetano, Mei, S., Milana, F., Pansa, A., Sacchi, Dario Marco, Testori, A., Di Carlo, Giampiero, Paratore, Mattia, Perrone, U., Vagge, A., Vigano, J., Torre, B., Scotti, M. A., Carbone, G., Cerchione, R., De Nardi, P., Gozzini, L., Ottaviani, Letizia, Senni, C., Piccin, O., Pio, L., Colombo, F., Avantifiori, R., Baldassarri, V., Caronna, R., Cicerchia, P. M., Corallino, D., Crocetti, D., Gallo, Giuseppe, Giovanardi, F., Giovannetti, F., Hassan, R., Iossa, A., Lai, Q., Lancellotti, F., Lucarini, A., Lucchese, S., Mazzarella, Giulio, Melandro, F., Minervini, A., Muttillo, E. M., Palmieri, L., Pasqua, R., Rosiello, F., Salina, Giulia, Sibio, S., Sirignano, P., Tarallo, M., Usai, S., Vanni, C., Viglietta, E., Zambon, M., Conversano, N. I., Epifani, A. G., Milano, Valentina, Sacco, L., Nava, Bruna Maria, Maffioli, A., Giuratrabocchetta, S., Baracchi, F., Zuolo, M., Ceresoli, M., Verdi, D., Belli, Andrea, Pata, F., Piovano, E., Pastore, G., Bernabei, F., Deiana, S., Arceri, A., D'Agostino, Cinzia, Marafante, C., Moggia, E., Parini, S., Moretti, M., Uggeri, F., Pontarolo, N., Fontana, T., Palmisano, Gerardo, Giuffrida, M., Guaitoli, E., Ferretti, C., Iacopino, G., Gioco, R., Roscitano, G., Montanelli, P., Chiappetta, M. F., Pinotti, E., Monati, E., Fazio, G., Di Pietro, F., Damarco, F., Barberis, A., Razzore, A., Pascale, A., Loi, S., Ferrara, F., Rossi, Marco, Lisi, G., Viel, G., Sasia, D., Bono, D., Cordaro, E. R., Giacomelli, E., Giani, I., Seriau, L., Pellino, Giuseppe, Sparavigna, M., Trigiante, G., D'Ambrogio, R. G., Cardella, F., Guzzetti, S., Luzzi, A. -P., Carganico, G., Drago, B., Micheletto, G., Orlandi, R., Cutolo, C., Gibello, U., Mistrangelo, M., Forcignano, E., D'Ugo, S., Losurdo, P., Manitto, M., Caroli, G., Franco, Manuela, Tilocca, P. L., Mendogni, P., Sena, G., Sambucci, D., Luciani, C., Atelli, P., Guida, Maria Antonietta, Marino, Filippo, Morini, A., Sibilla, M. G., Longo, Fabio, Giaccari, S., Vigorita, V., Balduzzi, A., Barra, F., Delogu, D., Milone, E., Bencini, L., Aprile, V., Papini, P., Montemurro, N., Cavallo, Michele, Picciariello, A., Tomasicchio, G., Fittipaldi, A., Maruccia, M., Gerardi, S., Cillara, N., Deidda, Silvia, Demarinis, G., Peiretti, E., Tatti, F., Iovino, C., Isola, G., Progno, V. C., Migliore, M., Badessi, G., Barilla, C., Calleri, G. S., Cianci, Stefano, Fama, F., Fleres, F., Mazzeo, C., Visaloco, M. G., Marchetto, C., Bolognesi, F., Benuzzi, L., Bracchetti, G., Brucchi, F., Manzo, C. A., Scaravilli, L., Ferrari, C., Rocca, A., Napolitano, Paola, Anoldo, P., Caricato, Chiara, Manigrasso, M., Milone, Maria, Napolitano, L., Palomba, G., Schiavone, V., Vetrella, M., Grossi, U., Moletta, L., Annicchiarico, A., Vella, I., Talesa, G., Boggi, U., Aiello, F., Anselmo, Anna, Bacchiocchi, G., Beati, F., Bellato, V., Billeci, F., Blasi, F., Buonomo, O. C., Campanelli, M., Coco, G., Contadini, A., Conte, L. E., D'Ippolito, G., Di Marcantonio, A., Spicchiale, C. F., Afflitto, G. G., Gismondi, A., Gorgolini, G., Granai, A. V., Grande, S., Gravina, A., Guida, A. M., Ingallinella, S., Keci, L., Latini, E., Marino, D., Oddi, F. M., Orecchia, L., Don, C. B. P., Pellicciaro, M., Petagna, L., Pirozzi, B. M., Quaranta, Caterina, Rho, M., Rosina, Alessandro, Santicchia, M. S., Saraceno, F., Schiavone, A., Sensi, B., Spina, A., Sullo, L., Tacconi, F., Taje, R., Vanni, G., Vinci, D., Vita, G., Alba, G., Badalucco, S., Carbone, Luigi, Samorani, O. C., Chisci, G., Cuomo, Rosa, Francia, A., Fusario, D., Gargiulo, B., Pasqui, E., Pasquetti, L., Puoti, P., Resca, L., Cumbo, J., Ganio, S., Vizzielli, Giuseppe, Anastasi, M., Guerra, D., Romanzi, A., Vannelli, A., Baia, M., Giordano L., Barone M., Corti S., Marangi G. (ORCID:0000-0002-6898-8882), Santini S. (ORCID:0000-0003-1956-5899), Ardito F. (ORCID:0000-0003-1596-2862), Belia F., Biondi A. (ORCID:0000-0002-2470-7858), Brisinda G. (ORCID:0000-0001-8820-9471), Ciolli A., Ferracci F., Fiorillo C. (ORCID:0000-0001-7681-3567), Fransvea P. (ORCID:0000-0003-4969-3373), La Greca A. (ORCID:0000-0002-7587-7427), Litta F., Panettieri E., Papa V. (ORCID:0000-0002-3709-8924), Patini R. (ORCID:0000-0001-7358-8763), Perrotta G., Puccioni C., Musumeci G., Berardi G., Ferretti S., Mariano G., Mangiameli G., Sacchi M. (ORCID:0000-0003-2826-8431), Di Carlo G., Paratore M., Ottaviani L. (ORCID:0009-0001-0967-8809), Gallo G., Mazzarella G., Salina G., Milano V., Nava M., Belli A., D'Agostino C., Palmisano G., Rossi M. (ORCID:0000-0002-4539-5670), Pellino G., Franco M., Guida A., Marino F., Longo F., Cavallo M., Deidda S., Cianci S., Napolitano P., Caricato C., Milone M., Anselmo A., Quaranta C., Rosina A. (ORCID:0000-0002-0158-0583), Carbone L., Cuomo R., Vizzielli G., Siragusa, L., Angelico, R., Angrisani, M., Zampogna, B., Materazzo, M., Sorge, R., Giordano, Lucia, Meniconi, R., Coppola, A., Marino, A., Giraudo, G., Esposito, S., Urbani, A., De Pastena, M., Mastrapasqua, R., Garancini, M., Frontal, A., Pascal, G., Martellucc, J., Falb, F., Boscarelli, A., Bertoglio, P., Trecca, E., Galassi, L., Vento, V., Chiappini, A., Antonelli, A., Bennardo, F., Familiari, F., Giannaccare, G., Zappia, A. S., Giuliani, G., Falcone, F., Sebastiani, S., Montuori, M., Rossi, S., Sagnotta, A., Giuliani, B., Imbriani, G. C., Restaino, S., Andreani, L., Di Maria, F., Lagana, A. S., Vitiello, L., Berton, F., Virgilio, E., Palisi, M., Portigliotti, L., Calussi, M., Conti, L., Mauriello, C., Barone, Alessia Maria Addolorata, Saladino, E., Giaquinta, A., Zerb, D., Frazzetta, G., Merola, G., Chierici, A., Bini, R., Centonze, L., De Carlis, R., Ferrario, L., Giani, A., Lauterio, A., Tamini, N., Corti, Serafino, Botteri, E., Andreuccetti, J., D'Alessio, R., Cestaro, G., Clarizia, G., Spolini, A., Carboni, A. S., Benzoni, E., Galiffa, G., Perotti, B., Veroux, M., Randazzo, V., Topa, D., Pranteda, C., Contini, G., Iacusso, C., Voglino, V., Vita, P., Carrano, F. M., Ambrosio, L., Cammarata, R., Capolupo, G. T., Caputo, D., Carannante, F., Cascone, C., Esperto, F., Farolfi, T., Frasca, L., Gallo, I. F., Gibin, G., Giurazza, G., Improta, L., La Vaccara, V., Luffarelli, P., Luvero, D., Marangi, Giuseppe, Masciana, G., Mazzola, A., Mazzotta, E., Miligi, C. I., Montelione, N., Nenna, A., Orsaria, P., Papalia, R., Papalia, G. F., Parisi, F. R., Prata, F., Salzillo, R., Santini, Stefano Angelo, Sofo, F., Zampoli, A., Tanda, C., Altieri, G., Ardito, Francesco, Belia, Francesco, Bianchi, V., Biondi, Alberto, Brisinda, Giuseppe, Chiappetta, M., Ciolli, G., Ciolli, Alessandro, Ferracci, Federica, Ferri, L., Fico, V., Fiorillo, Claudio, Fransvea, Pietro, Galiandro, F., Giovinazzo, F., La Greca, Antonio, Litta, Francesco, Mele, C., Pafundi, D. P., Panettieri, Elena, Papa, Valerio, Patini, Romeo, Perrotta, Generoso, Puccioni, Caterina, Santocchi, P., Armatura, G., Olmi, S., Casoni Pattacini, G., Salgarello, S., Trompetto, M., Bombardini, C., La Rocca, R., Celentano, G., Micalef, A., Mazzella, A., Settembrini, A., Zoia, C., Degrate, L., Musumeci, Giampaolo, Palopoli, C. A. M., Montori, G., Bonati, E., Dinuzzi, V. P., Velluti, F., Balla, A., Bonasia, D. E., Coletta, D., Berardi, Giulia, Colasanti, M., Ferretti, Serena, Gasparoli, C., Mariano, Giuseppantonio, Avenia, S., Cianci, P., Cestino, L., Festa, F., Fazio, F., Ascari, F., Desio, M., Arroyo Murillo, G. A., Cereda, M., Galleano, R., David, G., Pansini, A., Gazia, C., Atzori, G., Desideri, L. F., Famularo, S., Galvanin, J., Giudici, V. M., Mangiameli, Gaetano, Mei, S., Milana, F., Pansa, A., Sacchi, Dario Marco, Testori, A., Di Carlo, Giampiero, Paratore, Mattia, Perrone, U., Vagge, A., Vigano, J., Torre, B., Scotti, M. A., Carbone, G., Cerchione, R., De Nardi, P., Gozzini, L., Ottaviani, Letizia, Senni, C., Piccin, O., Pio, L., Colombo, F., Avantifiori, R., Baldassarri, V., Caronna, R., Cicerchia, P. M., Corallino, D., Crocetti, D., Gallo, Giuseppe, Giovanardi, F., Giovannetti, F., Hassan, R., Iossa, A., Lai, Q., Lancellotti, F., Lucarini, A., Lucchese, S., Mazzarella, Giulio, Melandro, F., Minervini, A., Muttillo, E. M., Palmieri, L., Pasqua, R., Rosiello, F., Salina, Giulia, Sibio, S., Sirignano, P., Tarallo, M., Usai, S., Vanni, C., Viglietta, E., Zambon, M., Conversano, N. I., Epifani, A. G., Milano, Valentina, Sacco, L., Nava, Bruna Maria, Maffioli, A., Giuratrabocchetta, S., Baracchi, F., Zuolo, M., Ceresoli, M., Verdi, D., Belli, Andrea, Pata, F., Piovano, E., Pastore, G., Bernabei, F., Deiana, S., Arceri, A., D'Agostino, Cinzia, Marafante, C., Moggia, E., Parini, S., Moretti, M., Uggeri, F., Pontarolo, N., Fontana, T., Palmisano, Gerardo, Giuffrida, M., Guaitoli, E., Ferretti, C., Iacopino, G., Gioco, R., Roscitano, G., Montanelli, P., Chiappetta, M. F., Pinotti, E., Monati, E., Fazio, G., Di Pietro, F., Damarco, F., Barberis, A., Razzore, A., Pascale, A., Loi, S., Ferrara, F., Rossi, Marco, Lisi, G., Viel, G., Sasia, D., Bono, D., Cordaro, E. R., Giacomelli, E., Giani, I., Seriau, L., Pellino, Giuseppe, Sparavigna, M., Trigiante, G., D'Ambrogio, R. G., Cardella, F., Guzzetti, S., Luzzi, A. -P., Carganico, G., Drago, B., Micheletto, G., Orlandi, R., Cutolo, C., Gibello, U., Mistrangelo, M., Forcignano, E., D'Ugo, S., Losurdo, P., Manitto, M., Caroli, G., Franco, Manuela, Tilocca, P. L., Mendogni, P., Sena, G., Sambucci, D., Luciani, C., Atelli, P., Guida, Maria Antonietta, Marino, Filippo, Morini, A., Sibilla, M. G., Longo, Fabio, Giaccari, S., Vigorita, V., Balduzzi, A., Barra, F., Delogu, D., Milone, E., Bencini, L., Aprile, V., Papini, P., Montemurro, N., Cavallo, Michele, Picciariello, A., Tomasicchio, G., Fittipaldi, A., Maruccia, M., Gerardi, S., Cillara, N., Deidda, Silvia, Demarinis, G., Peiretti, E., Tatti, F., Iovino, C., Isola, G., Progno, V. C., Migliore, M., Badessi, G., Barilla, C., Calleri, G. S., Cianci, Stefano, Fama, F., Fleres, F., Mazzeo, C., Visaloco, M. G., Marchetto, C., Bolognesi, F., Benuzzi, L., Bracchetti, G., Brucchi, F., Manzo, C. A., Scaravilli, L., Ferrari, C., Rocca, A., Napolitano, Paola, Anoldo, P., Caricato, Chiara, Manigrasso, M., Milone, Maria, Napolitano, L., Palomba, G., Schiavone, V., Vetrella, M., Grossi, U., Moletta, L., Annicchiarico, A., Vella, I., Talesa, G., Boggi, U., Aiello, F., Anselmo, Anna, Bacchiocchi, G., Beati, F., Bellato, V., Billeci, F., Blasi, F., Buonomo, O. C., Campanelli, M., Coco, G., Contadini, A., Conte, L. E., D'Ippolito, G., Di Marcantonio, A., Spicchiale, C. F., Afflitto, G. G., Gismondi, A., Gorgolini, G., Granai, A. V., Grande, S., Gravina, A., Guida, A. M., Ingallinella, S., Keci, L., Latini, E., Marino, D., Oddi, F. M., Orecchia, L., Don, C. B. P., Pellicciaro, M., Petagna, L., Pirozzi, B. M., Quaranta, Caterina, Rho, M., Rosina, Alessandro, Santicchia, M. S., Saraceno, F., Schiavone, A., Sensi, B., Spina, A., Sullo, L., Tacconi, F., Taje, R., Vanni, G., Vinci, D., Vita, G., Alba, G., Badalucco, S., Carbone, Luigi, Samorani, O. C., Chisci, G., Cuomo, Rosa, Francia, A., Fusario, D., Gargiulo, B., Pasqui, E., Pasquetti, L., Puoti, P., Resca, L., Cumbo, J., Ganio, S., Vizzielli, Giuseppe, Anastasi, M., Guerra, D., Romanzi, A., Vannelli, A., Baia, M., Giordano L., Barone M., Corti S., Marangi G. (ORCID:0000-0002-6898-8882), Santini S. (ORCID:0000-0003-1956-5899), Ardito F. (ORCID:0000-0003-1596-2862), Belia F., Biondi A. (ORCID:0000-0002-2470-7858), Brisinda G. (ORCID:0000-0001-8820-9471), Ciolli A., Ferracci F., Fiorillo C. (ORCID:0000-0001-7681-3567), Fransvea P. (ORCID:0000-0003-4969-3373), La Greca A. (ORCID:0000-0002-7587-7427), Litta F., Panettieri E., Papa V. (ORCID:0000-0002-3709-8924), Patini R. (ORCID:0000-0001-7358-8763), Perrotta G., Puccioni C., Musumeci G., Berardi G., Ferretti S., Mariano G., Mangiameli G., Sacchi M. (ORCID:0000-0003-2826-8431), Di Carlo G., Paratore M., Ottaviani L. (ORCID:0009-0001-0967-8809), Gallo G., Mazzarella G., Salina G., Milano V., Nava M., Belli A., D'Agostino C., Palmisano G., Rossi M. (ORCID:0000-0002-4539-5670), Pellino G., Franco M., Guida A., Marino F., Longo F., Cavallo M., Deidda S., Cianci S., Napolitano P., Caricato C., Milone M., Anselmo A., Quaranta C., Rosina A. (ORCID:0000-0002-0158-0583), Carbone L., Cuomo R., and Vizzielli G.

Abstract

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March–April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients’ management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons’ personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon–patient/family communication. From the Italian surgeons’ perspective, COVID-related measures will continue to influence

Published
2023

16. Sustainability and COVID-19

Author

Anselmo, Anna

Abstract

This essay pursues the following aims: firstly, UN definitions of sustainability are analysed to see how the concept is framed in international discourse; secondly, the institutional connection between COVID-19 and the UN’s Sustainable Development Goals (SDGs) is analysed; lastly, the online Coronavirus Corpus is interrogated in order to establish whether online news outlets from twenty English-speaking countries show textual evidence of the institutional connection between COVID-19 and sustainability, and whether the semantics of sustainability in the press correspond to the UN’s. In the analysis, emphasis is laid on the co-occurrence of a set of multi-word expressions, combinations of sustainable, sustainability, and COVID-19., Iperstoria, No. 20 (2022): Changing the (Cultural) Climate with Ecocriticism and Ecolinguistics

Published
2022
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17. Meningococci of serogroup X clonal complex 181 in refugee camps, Italy

Author

Stefanelli, Paola, Neri, Arianna, Vacca, Paola, Picicco, Damiano, Daprai, Laura, Mainardi, Giulia, Rossolini, Gian Maria, Bartoloni, Alessandro, Anselmo, Anna, Ciammaruconi, Andrea, Fortunato, Antonella, Palozzi, Anna Maria, Fillo, Silvia, Faccini, Marino, Senatore, Sabrina, Lista, Florigio, and Fazio, Cecilia

Subjects
Health aspects, Refugees -- Health aspects, Meningitis -- Health aspects, Refugee camps -- Health aspects
Abstract

Outbreaks of Neisseria meningitidis serogroup X meningococcal (MenX) infections in the African meningitis belt caused by isolates of clonal complex (CC) 181, including an outbreak in 2006 in Niger and [...]

Published
2017

19. Analysis of Genomic Characteristics of SARS-CoV-2 in Italy, 29 January to 27 March 2020

Author

Lo Presti, Alessandra, primary, Di Martino, Angela, additional, Faggioni, Giovanni, additional, Giordani, Francesco, additional, Fillo, Silvia, additional, Anselmo, Anna, additional, Fain, Vanessa Vera, additional, Fortunato, Antonella, additional, Petralito, Giancarlo, additional, Molinari, Filippo, additional, Palomba, Stefano, additional, De Santis, Riccardo, additional, Fiore, Stefano, additional, Fabiani, Concetta, additional, Di Mario, Giuseppina, additional, Facchini, Marzia, additional, Calzoletti, Laura, additional, Lista, Florigio, additional, Rezza, Giovanni, additional, and Stefanelli, Paola, additional

Published
2022
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20. Molecular characterisation and antibiotic susceptibility of meningococcal isolates from healthy men who have sex with men

Author

Neri, Arianna, primary, Palmieri, Annapina, additional, Prignano, Grazia, additional, Giuliani, Massimo, additional, Latini, Alessandra, additional, Fazio, Cecilia, additional, Vacca, Paola, additional, Ambrosio, Luigina, additional, Ciammaruconi, Andrea, additional, Fillo, Silvia, additional, Anselmo, Anna, additional, Fortunato, Antonella, additional, Lista, Romano, additional, and Stefanelli, Paola, additional

Published
2021
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23. Analyses of pig genomes provide insight into porcine demography and evolution

Author

Groenen, Martien A. M., Archibald, Alan L., Uenishi, Hirohide, Tuggle, Christopher K., Takeuchi, Yasuhiro, Rothschild, Max F., Rogel-Gaillard, Claire, Park, Chankyu, Milan, Denis, Megens, Hendrik-Jan, Li, Shengting, Larkin, Denis M., Kim, Heebal, Frantz, Laurent A. F., Caccamo, Mario, Ahn, Hyeonju, Aken, Bronwen L., Anselmo, Anna, Anthon, Christian, Auvil, Loretta, Badaoui, Bouabid, Beattie, Craig W., Bendixen, Christian, Berman, Daniel, Blecha, Frank, Blomberg, Jonas, Bolund, Lars, Bosse, Mirte, Botti, Sara, Bujie, Zhan, Bystrom, Megan, Capitanu, Boris, Carvalho-Silva, Denise, Chardon, Patrick, Chen, Celine, Cheng, Ryan, Choi, Sang-Haeng, Chow, William, Clark, Richard C., Clee, Christopher, Crooijmans, Richard P. M. A., Dawson, Harry D., Dehais, Patrice, De Sapio, Fioravante, Dibbits, Bert, Drou, Nizar, Du, Zhi-Qiang, Eversole, Kellye, Fadista, João, Fairley, Susan, Faraut, Thomas, Faulkner, Geoffrey J., Fowler, Katie E., Fredholm, Merete, Fritz, Eric, Gilbert, James G. R., Giuffra, Elisabetta, Gorodkin, Jan, Griffin, Darren K., Harrow, Jennifer L., Hayward, Alexander, Howe, Kerstin, Hu, Zhi-Liang, Humphray, Sean J., Hunt, Toby, Hornshøj, Henrik, Jeon, Jin-Tae, Jern, Patric, Jones, Matthew, Jurka, Jerzy, Kanamori, Hiroyuki, Kapetanovic, Ronan, Kim, Jaebum, Kim, Jae-Hwan, Kim, Kyu-Won, Kim, Tae-Hun, Larson, Greger, Lee, Kyooyeol, Lee, Kyung-Tai, Leggett, Richard, Lewin, Harris A., Li, Yingrui, Liu, Wansheng, Loveland, Jane E., Lu, Yao, Lunney, Joan K., Ma, Jian, Madsen, Ole, Mann, Katherine, Matthews, Lucy, McLaren, Stuart, Morozumi, Takeya, Murtaugh, Michael P., Narayan, Jitendra, Truong Nguyen, Dinh, Ni, Peixiang, Oh, Song-Jung, Onteru, Suneel, Panitz, Frank, Park, Eung-Woo, Park, Hong-Seog, Pascal, Geraldine, Paudel, Yogesh, Perez-Enciso, Miguel, Ramirez-Gonzalez, Ricardo, Reecy, James M., Rodriguez-Zas, Sandra, Rohrer, Gary A., Rund, Lauretta, Sang, Yongming, Schachtschneider, Kyle, Schraiber, Joshua G., Schwartz, John, Scobie, Linda, Scott, Carol, Searle, Stephen, Servin, Bertrand, Southey, Bruce R., Sperber, Goran, Stadler, Peter, Sweedler, Jonathan V., Tafer, Hakim, Thomsen, Bo, Wali, Rashmi, Wang, Jian, Wang, Jun, White, Simon, Xu, Xun, Yerle, Martine, Zhang, Guojie, Zhang, Jianguo, Zhang, Jie, Zhao, Shuhong, Rogers, Jane, Churcher, Carol, and Schook, Lawrence B.

Published
2012
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26. The Discourse of Lawfulness in Representations of the Peterloo Massacre: A Lexical and Critical Discourse Analysis.

Author

Anselmo, Anna

Subjects
CRITICAL discourse analysis, CONSPIRACY theories, APPLIED linguistics, ROMANTICISM, LIGHTWEIGHT construction, POLITICAL debates, MEDIA studies, MASSACRES
Abstract

The article employs critical discourse analysis to shed light on the linguistic construction of political discourse in the Romantic Period. The aim is to fill a gap in the literature by integrating the critical tools of applied linguistics with Romantic media texts. Such hermeneutic effort is intended to complement the cultural turn in Romantic Studies thanks to an unprecedented focus on the lexical and syntactical construction of both political debate and the dynamics of political struggle in England in 1819. The corpus consists of five texts published in three daily papers, The Times, The Morning Chronicle, and The Courier, and two weeklies, Sherwin's Political Register and The Examiner in the immediate aftermath of the Peterloo massacre. These were selected as representative of a range of competing political stances and ideologies. The first part of the article presents the sociocultural discourse of lawfulness at the turn of the nineteenth century, and contains reflections on language, politics, and the law. The second part introduces the corpus and the methodology employed for its analysis (van Leeuwen's social actor theory), as well as presenting the #Lancsbox software and its use in the analysis of the corpus. The third part analyses the corpus using social actor theory to demonstrate that media representations of Peterloo are acts of cultural appropriation that construe it either as a conspiracy or as a legitimate act of self-defence. In this fashion, the article wishes to complement work on Peterloo-inspired literature (poetry in particular), by offering an alternative perspective on the event and its diverse textual representations. [ABSTRACT FROM AUTHOR]

Published
2022

27. Molecular characterisation and antibiotic susceptibility of meningococcal isolates from healthy men who have sex with men.

Author

Neri, Arianna, Palmieri, Annapina, Prignano, Grazia, Giuliani, Massimo, Latini, Alessandra, Fazio, Cecilia, Vacca, Paola, Ambrosio, Luigina, Ciammaruconi, Andrea, Fillo, Silvia, Anselmo, Anna, Fortunato, Antonella, Lista, Romano, and Stefanelli, Paola

Abstract

Objectives: To evaluate and characterise meningococcal carriage among healthy men who have sex with men (MSM) within a screening programme for Neisseria gonorrhoeae infection at the San Gallicano Dermatological Institute, Italy.Methods: A total of 441 MSM attending the STI/HIV Centre of the San Gallicano Institute, Rome, Italy, in 2016 were routinely screened for N. gonorrhoeae infection by pharyngeal and rectal swabs. N. meningitidis isolates were evaluated for antibiotic susceptibility and characterised by whole genome sequencing. Genetic relationships among the meningococcal carriage isolates were determined using core genome multilocus sequence typing analysis. The soluble domain of AniA (sAniA) protein expression by western blotting was also evaluated.Results: A total of 62 (14.1%, 95% CI 11.1 to 17.6) carriage meningococci were found among 441 MSM. Forty-three viable N. meningitidis isolates were cultivated (42 from pharyngeal and 1 from rectal swabs). All the viable isolates were susceptible to cefotaxime, ceftriaxone, ciprofloxacin and rifampicin. Four isolates were penicillin G-resistant and 73% of those penicillin G-susceptible showed a minimum inhibitory concentration from 0.064 μg/mL to 0.25 μg/mL. Serogroup B was the most frequent (44.2%), followed by Z (16.3%), E (9.3%), and Y and W (2.3%), respectively. Multilocus sequence typing analysis identified 29 sequence types belonging to 12 clonal complexes. The sAniA protein was expressed in 8 out of 28 (29%) screened meningococcal carriage isolates.Conclusions: Serogroup B meningococcal carriage identified from oral and anal specimens among healthy MSM was the most frequent serogroup identified in this study. Molecular evaluation revealed a degree of similarity among strains belonging to the same clonal complex. [ABSTRACT FROM AUTHOR]

Published
2022
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28. A Retrospective Whole-Genome Sequencing Analysis of Carbapenem and Colistin-Resistant Klebsiella Pneumoniae Nosocomial Strains Isolated during an MDR Surveillance Program

Author

Gentile, Bernardina, Grottola, Antonella, Orlando, Gabriella, Serpini, Giulia Fregni, Venturelli, Claudia, Meschiari, Marianna, Anselmo, Anna, Fillo, Silvia, Fortunato, Antonella, Lista, Florigio, Pecorari, Monica, and Mussini, Cristina

Subjects
Klebsiella pneumoniae, lcsh:Therapeutics. Pharmacology, whole-genome sequencing, lcsh:RM1-950, polycyclic compounds, Genetic relatedness, MDR nosocomial spread, Whole-genome sequencing, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Article, genetic relatedness
Abstract

Multidrug-resistant Klebsiella pneumoniae (MDR Kp), in particular carbapenem-resistant Kp (CR-Kp), has become endemic in Italy, where alarming data have been reported on the spread of colistin-resistant CR-Kp (CRCR-Kp). During the period 2013&ndash, 2014, 27 CRCR-Kp nosocomial strains were isolated within the Modena University Hospital Policlinico (MUHP) multidrug resistance surveillance program. We retrospectively investigated these isolates by whole-genome sequencing (WGS) analysis of the resistome, virulome, plasmid content, and core single nucleotide polymorphisms (cSNPs) in order to gain insights into their molecular epidemiology. The in silico WGS analysis of the resistome revealed the presence of genes, such as blaKPC, related to the phenotypically detected resistances to carbapenems. Concerning colistin resistance, the plasmidic genes mcr 1&ndash, 9 were not detected, while known and new genetic variations in mgrB, phoQ, and pmrB were found. The virulome profile revealed the presence of type-3 fimbriae, capsular polysaccharide, and iron acquisition system genes. The detected plasmid replicons were classified as IncFIB(pQil), IncFIB(K), ColRNAI, IncX3, and IncFII(K) types. The cSNPs genotyping was consistent with the multi locus sequence typing (MLST) and with the distribution of mutations related to colistin resistance genes. In a nosocomial drug resistance surveillance program, WGS proved to be a useful tool for elucidating the spread dynamics of CRCR-Kp nosocomial strains and could help to limit their diffusion.

Published
2020

30. Human Fibroblasts In Vitro Exposed to 2.45 GHz Continuous and Pulsed Wave Signals: Evaluation of Biological Effects with a Multimethodological Approach

Author

Regalbuto, Elisa, primary, Anselmo, Anna, additional, De Sanctis, Stefania, additional, Franchini, Valeria, additional, Lista, Florigio, additional, Benvenuto, Monica, additional, Bei, Roberto, additional, Masuelli, Laura, additional, D’Inzeo, Guglielmo, additional, Paffi, Alessandra, additional, Trodella, Eugenio, additional, and Sgura, Antonella, additional

Published
2020
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32. Posthuman Keats. Poetry as Assemblage

Author

Anselmo, Anna

Subjects
lcsh:Language and Literature, Keats, posthumanism, cyborg, assemblage, Donna Haraway, lcsh:Literature (General), lcsh:P, lcsh:PN1-6790
Abstract

This article explores the notions of flotsam, jetsam and hybridity in John Keats’s poetry in order to provide a critical reading informed by posthumanist theories, and, more specifically, Donna Haraway’s cyborg. It starts with the metaphor of debris and the linguistic-literary metaphor of texture/textus. It then proceeds to elucidate how Keats deals with flotsam and jetsam in his work. A short overview of the theory of organic unity begins the last section of the article, which focuses on the poet’s penchant for hybrid poetic endeavours and envisions some of his work as a metaphorical manifestation of the cyborg myth., Altre Modernità, 2020: NUMERO SPECIALE: Sc[Arti]: Riflessioni sul residuo tra selezione e divergenza

Published
2020

33. SCIENCE-RELATED POPULISM AND SOCIAL ACTORS IN MARTIN GEDDES' EARLY REPRESENTATIONS OF COVID-19: A Case Study.

Author

ANSELMO, ANNA

Subjects
COVID-19 pandemic, CONSPIRACY theories, SYNDEMICS, CRITICAL discourse analysis, SKEPTICISM
Abstract

This article focuses on five blogs written by British conspiracy theorist Martin Geddes, available on his personal website. The blogs were written from March to December 2020 and represent an early testimony of COVID-19 scepticism. The article aims to analyse Geddes' conspirational counter-narrative of the coronavirus syndemic by focusing on four elements: the generic characteristics of the corpus, Geddes' construal of ethos, his texts' connection to the theoretical framework of science-related populism and, lastly, the representation of select social actors in the corpus and how such representation sustains Geddes' conspirational arguments. These elements provide insight into the idiom of conspiracy theorists and their construction of counter-information and counterknowledge. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Rapidly Alternating COPP/ABV/IMEP Is Not Superior to Conventional Alternating COPP/ABVD in Combination With Extended-Field Radiotherapy in Intermediate-Stage Hodgkin’s Lymphoma: Final Results of the German Hodgkin’s Lymphoma Study Group Trial HD5

Author

Sieber, Markus, Tesch, Hans, Pfistner, Beate, Rueffer, Ulrich, Lathan, Bernd, Brosteanu, Oana, Paulus, Ursula, Koch, Tina, Pfreundschuh, Michael, Loeffler, Markus, Engert, Andreas, Josting, Andreas, Wolf, Jürgen, Hasenclever, Dirk, Franklin, Jeremy, Duehmke, Eckhart, Georgii, Axel, Schalk, Klaus-Peter, Kirchner, Hartmut, Doelken, Gottfried, Munker, Reinhold, Koch, Peter, Herrmann, Richard, Greil, Richard, Anselmo, Anna Paola, and Diehl, Volker

Published
2002

37. MOESM1 of Co-existence of virulence factors and antibiotic resistance in new Klebsiella pneumoniae clones emerging in south of Italy

Author

Fasciana, Teresa, Gentile, Bernardina, Aquilina, Maria, Ciammaruconi, Andrea, Mascarella, Chiara, Anselmo, Anna, Fortunato, Antonella, Fillo, Silvia, Petralito, Giancarlo, Florigio Lista, and Giammanco, Anna

Subjects
respiratory tract diseases
Abstract

Additional file 1. K. pneumoniae CR antibiotic resistance profile. Results of antibiotic resistance assay of K. pneumoniae CR.

Published
2019
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40. Identification of tumor-associated cassette exons in human cancer through EST-based computational prediction and experimental validation

Author

Valletti Alessio, Anselmo Anna, Mangiulli Marina, Boria Ilenia, Mignone Flavio, Merla Giuseppe, D'Angelo Vincenzo, Tullo Apollonia, Sbisà Elisabetta, D'Erchia Anna, and Pesole Graziano

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Many evidences report that alternative splicing, the mechanism which produces mRNAs and proteins with different structures and functions from the same gene, is altered in cancer cells. Thus, the identification and characterization of cancer-specific splice variants may give large impulse to the discovery of novel diagnostic and prognostic tumour biomarkers, as well as of new targets for more selective and effective therapies. Results We present here a genome-wide analysis of the alternative splicing pattern of human genes through a computational analysis of normal and cancer-specific ESTs from seventeen anatomical groups, using data available in AspicDB, a database resource for the analysis of alternative splicing in human. By using a statistical methodology, normal and cancer-specific genes, splice sites and cassette exons were predicted in silico. The condition association of some of the novel normal/tumoral cassette exons was experimentally verified by RT-qPCR assays in the same anatomical system where they were predicted. Remarkably, the presence in vivo of the predicted alternative transcripts, specific for the nervous system, was confirmed in patients affected by glioblastoma. Conclusion This study presents a novel computational methodology for the identification of tumor-associated transcript variants to be used as cancer molecular biomarkers, provides its experimental validation, and reports specific biomarkers for glioblastoma.

Published
2010
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42. Genome-wide identification of coding and non-coding conserved sequence tags in human and mouse genomes

Author

Maggi Giorgio P, Donvito Giacinto, Anselmo Anna, Mignone Flavio, Grillo Giorgio, and Pesole Graziano

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background The accurate detection of genes and the identification of functional regions is still an open issue in the annotation of genomic sequences. This problem affects new genomes but also those of very well studied organisms such as human and mouse where, despite the great efforts, the inventory of genes and regulatory regions is far from complete. Comparative genomics is an effective approach to address this problem. Unfortunately it is limited by the computational requirements needed to perform genome-wide comparisons and by the problem of discriminating between conserved coding and non-coding sequences. This discrimination is often based (thus dependent) on the availability of annotated proteins. Results In this paper we present the results of a comprehensive comparison of human and mouse genomes performed with a new high throughput grid-based system which allows the rapid detection of conserved sequences and accurate assessment of their coding potential. By detecting clusters of coding conserved sequences the system is also suitable to accurately identify potential gene loci. Following this analysis we created a collection of human-mouse conserved sequence tags and carefully compared our results to reliable annotations in order to benchmark the reliability of our classifications. Strikingly we were able to detect several potential gene loci supported by EST sequences but not corresponding to as yet annotated genes. Conclusion Here we present a new system which allows comprehensive comparison of genomes to detect conserved coding and non-coding sequences and the identification of potential gene loci. Our system does not require the availability of any annotated sequence thus is suitable for the analysis of new or poorly annotated genomes.

Published
2008
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43. TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells

Author

Romano, Benedetta, Elangovan, S., Erreni, M., Sala, Elisabetta, Petti, Livia, Kunderfranco, P., Massimino, L., Restelli, S., Sinha, S., Lucchetti, Donatella, Anselmo, Anna, Colombo, F. S., Stravalaci, M., Arena, Vincenzo, D'Alessio, S., Ungaro, Francesco, Inforzato, A., Izzo, A. A., Sgambato, Alessandro, Day, A. J., Vetrano, S., Romano B., Sala E., Petti L., Lucchetti D. (ORCID:0000-0001-8147-0079), Anselmo A., Arena V. (ORCID:0000-0002-7562-223X), Ungaro F., Sgambato A. (ORCID:0000-0002-9487-4563), Romano, Benedetta, Elangovan, S., Erreni, M., Sala, Elisabetta, Petti, Livia, Kunderfranco, P., Massimino, L., Restelli, S., Sinha, S., Lucchetti, Donatella, Anselmo, Anna, Colombo, F. S., Stravalaci, M., Arena, Vincenzo, D'Alessio, S., Ungaro, Francesco, Inforzato, A., Izzo, A. A., Sgambato, Alessandro, Day, A. J., Vetrano, S., Romano B., Sala E., Petti L., Lucchetti D. (ORCID:0000-0001-8147-0079), Anselmo A., Arena V. (ORCID:0000-0002-7562-223X), Ungaro F., and Sgambato A. (ORCID:0000-0002-9487-4563)

Abstract

Mesenchymal stem cells (MSCs) are well established to have promising therapeutic properties. TNF-stimulated gene-6 (TSG-6), a potent tissue-protective and anti-inflammatory factor, has been demonstrated to be responsible for a significant part of the tissue-protecting properties mediated by MSCs. Nevertheless, current knowledge about the biological function of TSG-6 in MSCs is limited. Here, we demonstrated that TSG-6 is a crucial factor that influences many functional properties of MSCs. The transcriptomic sequencing analysis of wild-type (WT) and TSG-6−/−-MSCs shows that the loss of TSG-6 expression leads to the perturbation of several transcription factors, cytokines, and other key biological pathways. TSG-6−/−-MSCs appeared morphologically different with dissimilar cytoskeleton organization, significantly reduced size of extracellular vesicles, decreased cell proliferative rate, and loss of differentiation abilities compared with the WT cells. These cellular effects may be due to TSG-6-mediated changes in the extracellular matrix (ECM) environment. The supplementation of ECM with exogenous TSG-6, in fact, rescued cell proliferation and changes in morphology. Importantly, TSG-6-deficient MSCs displayed an increased capacity to release interleukin-6 conferring pro-inflammatory and pro-tumorigenic properties to the MSCs. Overall, our data provide strong evidence that TSG-6 is crucial for the maintenance of stemness and other biological properties of murine MSCs.

Published
2019

44. The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium inaugural meeting report

Author

Afshinnekoo, Ebrahim, Ahsanuddin, Sofia, Ghedin, Elodie, Read, Timothy, Fraser, Claire, Dudley, Joel, Bowler, Christopher, Mason, Christopher E., Chernomoretz, Ariel, Stolovitzky, Gustavo, Łabaj, Paweł P., Graf, Alexandra B., Darling, Aaron, Burke, Catherine, Noushmehr, Houtan, Dias-Neto, Emmanuel, Guo, Yongli, Xie, Zhi, Lee, Patrick K. H., Shi, Leming, Ruiz-Perez, Carlos A., Zambrano, Maria Mercedes, Siam, Rania, Ouf, Amged, Richard, Hugues, Lafontaine, Ingrid, Wieler, Lothar H., Semmler, Torsten, Prithiviraj, Bharath, Nedunuri, Narasimha, Mehr, Shaadi, Banihashemi, Kambiz, Lista, Florigio, Anselmo, Anna, Suzuki, Haruo, Kuroda, Makoto, Yamashita, Riu, Sato, Yukoto, Kaminuma, Eli, Aranda, Celia M. Alpuche, Martinez, Jesus, Dada, Christopher, Dybwad, Marius, Oliveira, Manuela, Schuster, Stephan, Siwo, Geoffrey H., Jang, Soojin, Seo, Sung Chul, Hwang, Sung Ho, Ossowski, Stephan, Bezdan, Daniela, Chaker, Salama, Chatziefthimiou, Aspassia D., Udekwu, Klas, Liungdahl, Per, Sezerman, Ugur, Meydan, Cem, Elhaik, Eran, Gonnet, Gaston, Schriml, Lynn M., Mongodin, Emmanuel, Huttenhower, Curtis, Gilbert, Jack, Eisen, Jonathan, Hirschberg, David, Hernandez, Mark, McGrath, Ken, McGrath, Leanne, Gray, Andrew, Osuolale, Olayinka, Segata, Nicola, Fillo, Silvia, Iraola, Gregorio, Zhou, Yiming, Chang, Yujun, Li, Yang, Zhend, Yuanting, Hou, Wanwan, Ramirez, Adan, Cepeda, Martha, Desnues, Christelle, Rascovan, Nicolas, Baron, Colin, Nagarajan, Niranjan, Ercolini, Danilo, Menary, Wayne, Tighe, Scott, Donia, Mohamed, Levy, Shawn, Benito, Joseph, Jones, Angela, Kasarskis, Andrew, Maritz, Julia, Jorgensen, Ellen, Neches, Russell, Livelli, Tom, Barnetche, Jesus Martinez, Pasolli, Edoardo, Greenfield, Nick, Hasan, Nur, Brownstein, John, Nozick, Linda, Michels, Harold, Schriml, Lynn, Brownstein, Catherine, Garbarino, Jeanne, Lyons, Abby, Zhu, Jeff, Genome Center [UC Davis], University of California [Davis] (UC Davis), University of California (UC)-University of California (UC), American University in Cairo, Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (LCQB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Robert Koch Institute [Berlin] (RKI), Centre for Infection Medicine, Institute of Microbiology and Epizootics, Health Corps Italian Army, Department of Molecular Biology, Immunology and Experimental Medicine, Army Medical and Veterinary Research Center, Integrative Biology Unit, Parco Tecnologico Padano, Department of Environmental Science and Engineering, Graduate School of Science and Engineering, Department of Population Medicine and Diagnostic Sciences, Cornell University [New York], Dynamique cellulaire et moléculaire de la muqueuse respiratoire, Université de Reims Champagne-Ardenne (URCA)-IFR53-Institut National de la Santé et de la Recherche Médicale (INSERM), Biostatistics Department, Harvard School of Public Health, Institute for genomic and systems biology, Argonne National Laboratory [Lemont] (ANL), Department of Ecology and Evolution [Chicago], University of Chicago, Alfred P. Sloan Foundation [2015-13964], National Institutes of Health [F31GM111053, R01NS076465, R25EB020393], Promega, CosmosID, Illumina, Copan, QIAGEN, University of California-University of California, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Acibadem University Dspace, Afshinnekoo, Ebrahim, Ahsanuddin, Sofia, Ghedin, Elodie, Read, Timothy, Fraser, Claire, Dudley, Joel, Bowler, Christopher, Mason, Christopher E., Chernomoretz, Ariel, Stolovitzky, Gustavo, Łabaj, Paweł P., Graf, Alexandra B., Darling, Aaron, Burke, Catherine, Noushmehr, Houtan, Dias-Neto, Emmanuel, Guo, Yongli, Xie, Zhi, Lee, Patrick K. H., Shi, Leming, Ruiz-Perez, Carlos A., Zambrano, Maria Mercede, Siam, Rania, Ouf, Amged, Richard, Hugue, Lafontaine, Ingrid, Wieler, Lothar H., Semmler, Torsten, Prithiviraj, Bharath, Nedunuri, Narasimha, Mehr, Shaadi, Banihashemi, Kambiz, Lista, Florigio, Anselmo, Anna, Suzuki, Haruo, Kuroda, Makoto, Yamashita, Riu, Sato, Yukoto, Kaminuma, Eli, Aranda, Celia M. Alpuche, Martinez, Jesu, Dada, Christopher, Dybwad, Mariu, Oliveira, Manuela, Schuster, Stephan, Siwo, Geoffrey H., Jang, Soojin, Seo, Sung Chul, Hwang, Sung Ho, Ossowski, Stephan, Bezdan, Daniela, Chaker, Salama, Chatziefthimiou, Aspassia D., Udekwu, Kla, Liungdahl, Per, Sezerman, Ugur, Meydan, Cem, Elhaik, Eran, Gonnet, Gaston, Schriml, Lynn M., Mongodin, Emmanuel, Huttenhower, Curti, Gilbert, Jack, Eisen, Jonathan, Hirschberg, David, Hernandez, Mark, Mcgrath, Ken, Mcgrath, Leanne, Gray, Andrew, Osuolale, Olayinka, Segata, Nicola, Fillo, Silvia, Iraola, Gregorio, Zhou, Yiming, Chang, Yujun, Li, Yang, Zhend, Yuanting, Hou, Wanwan, Ramirez, Adan, Cepeda, Martha, Desnues, Christelle, Rascovan, Nicola, Baron, Colin, Nagarajan, Niranjan, Ercolini, Danilo, Menary, Wayne, Tighe, Scott, Donia, Mohamed, Levy, Shawn, Benito, Joseph, Jones, Angela, Kasarskis, Andrew, Maritz, Julia, Jorgensen, Ellen, Neches, Russell, Livelli, Tom, Barnetche, Jesus Martinez, Pasolli, Edoardo, Greenfield, Nick, Hasan, Nur, Brownstein, John, Nozick, Linda, Michels, Harold, Schriml, Lynn, Brownstein, Catherine, Garbarino, Jeanne, Lyons, Abby, and Zhu, Jeff

Subjects
0301 basic medicine, Microbiology (medical), Built environment, Antimicrobial resistance markers, [SDV]Life Sciences [q-bio], 030106 microbiology, BIOINFORMÁTICA, Biosynthetic gene cluster, Genomics, Biology, Meeting Report, Microbiology, Biosynthetic gene clusters, Microbiome, Next-generation sequencing, 12. Responsible consumption, Metagenomic, 03 medical and health sciences, Data visualization, Urban planning, Databases, Genetic, 11. Sustainability, City Planning, Architecture, Environmental planning, Ecosystem, Metadesign, business.industry, Antimicrobial resistance marker, Biotechnology, 030104 developmental biology, Research Design, 13. Climate action, Metagenomics, Public Health, Sample collection, business, Human
Abstract

International audience; The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium is a novel, interdisciplinary initiative comprised of experts across many fields, including genomics, data analysis, engineering, public health, and architecture. The ultimate goal of the MetaSUB Consortium is to improve city utilization and planning through the detection, measurement, and design of metagenomics within urban environments. Although continual measures occur for temperature, air pressure, weather, and human activity, including longitudinal, cross-kingdom ecosystem dynamics can alter and improve the design of cities. The MetaSUB Consortium is aiding these efforts by developing and testing metagenomic methods and standards, including optimized methods for sample collection, DNA/RNA isolation, taxa characterization, and data visualization. The data produced by the consortium can aid city planners, public health officials, and architectural designers. In addition, the study will continue to lead to the discovery of new species, global maps of antimicrobial resistance (AMR) markers, and novel biosynthetic gene clusters (BGCs). Finally, we note that engineered metagenomic ecosystems can help enable more responsive, safer, and quantified cities.

Published
2016
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45. Pericarditis caused by hyperinvasive strain of neisseria meningitidis, Sardinia, Italy, 2015

Author

Fazio, Cecilia, Castiglia, Paolo, Piana, Andrea, Neri, Arianna, Mura, Maria S., Caruana, Giorgia, Vacca, Paola, Anselmo, Anna, Ciammaruconi, Andrea, Fortunato, Antonella, Palozzi, Anna M., Fillo, Silvia, Lista, Florigio, and Stefanelli, Paola

Subjects
Sardinia -- Diseases, Sardinia -- Case studies, Diseases, Case studies, Causes of, Meningococcal infections -- Case studies, Neisseria meningitidis -- Case studies, Pericarditis -- Causes of -- Case studies
Abstract

To the Editor: Invasive meningococcal disease is usually defined by the occurrence of meningitis or septicemia. Pericarditis might occur during the course of invasive infection. This clinical picture, defined as [...]

Published
2016

46. Whole genome and phylogenetic analysis of two SARSCoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe.

Author

Stefanelli, Paola, Faggioni, Giovanni, Lo Presti, Alessandra, Fiore, Stefano, Marchi, Antonella, Benedetti, Eleonora, Fabiani, Concetta, Anselmo, Anna, Ciammaruconi, Andrea, Fortunato, Antonella, De Santis, Riccardo, Fillo, Silvia, Capobianchi, Maria Rosaria, Gismondo, Maria Rita, Ciervo, Alessandra, Rezza, Giovanni, Castrucci, Maria Rita, and Lista, Florigio

Published
2020
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48. Additional file 2: Figure S1. of Whole genome sequencing for the molecular characterization of carbapenem-resistant Klebsiella pneumoniae strains isolated at the Italian ASST Fatebenefratelli Sacco Hospital, 2012–2014

Author

Rimoldi, Sara, Gentile, Bernardina, Pagani, Cristina, Gregorio, Annamaria Di, Anselmo, Anna, Palozzi, Anna, Fortunato, Antonella, Pittiglio, Valentina, Ridolfo, Anna Lisa, Gismondo, Maria Rita, Rizzardini, Giuliano, and Florigio Lista

Abstract

GoeBURST diagram showing a “population snapshot” of the 68 carbapenem-resistant K. pneumoniae strains. Each sequence type (ST) is represented by a circle whose size reflects the number of strains sharing the same ST, and the number 1 indicates a difference of only one locus between the closest STs. The numbers in the table show the corresponding housekeeping gene alleles for each ST, and colored are those for single and double locus variants of ST258 (ST512, ST745 and ST1519), the “founder” of CC258. (PDF 93 kb)

Published
2017
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49. Additional file 3: of Whole genome sequencing for the molecular characterization of carbapenem-resistant Klebsiella pneumoniae strains isolated at the Italian ASST Fatebenefratelli Sacco Hospital, 2012â 2014

Author

Rimoldi, Sara, Gentile, Bernardina, Pagani, Cristina, Gregorio, Annamaria Di, Anselmo, Anna, Palozzi, Anna, Fortunato, Antonella, Pittiglio, Valentina, Ridolfo, Anna Lisa, Gismondo, Maria Rita, Rizzardini, Giuliano, and Florigio Lista

Abstract

Sequencing profiles of ompK35 and ompK36 of Kp27 strain ST101. (DOC 61Â kb)

Published
2017
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50. Additional file 5: Table S2. of Whole genome sequencing for the molecular characterization of carbapenem-resistant Klebsiella pneumoniae strains isolated at the Italian ASST Fatebenefratelli Sacco Hospital, 2012â 2014

Author

Rimoldi, Sara, Gentile, Bernardina, Pagani, Cristina, Gregorio, Annamaria Di, Anselmo, Anna, Palozzi, Anna, Fortunato, Antonella, Pittiglio, Valentina, Ridolfo, Anna Lisa, Gismondo, Maria Rita, Rizzardini, Giuliano, and Florigio Lista

Abstract

Sequence accession numbers of the carbapenem-resistant K. pneumoniae strains tested in this study (NCBI BioProject id: PRJNA 385863). (DOCX 13Â kb)

Published
2017
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