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Objectives: Modeling the processes involved in complex social interventions is important in social work practice, as it facilitates their implementation and translation into different contexts. This article reports the process of developing and modeling the connecting people intervention (CPI), a model of practice that supports people with mental health problems to enhance their social networks. Method: The CPI model was developed through an iterative process of focus group discussions with practitioners and service users and a two-stage Delphi consultation with relevant experts. Results: We discuss the intervention model and the processes it articulates to provide an example of the benefits of intervention modeling. Conclusions: Intervention modeling provides a visual representation of the process and outcomes of an intervention, which can assist practice development and lead to improved outcomes for service users.

As medical and health professions education (HPE) fields shift towards frameworks of justice, equity, diversity and inclusion (JEDI), there has been an increased focus on addressing the environments of learning to understand hierarchies of power and create better learning experiences for students who have historically been marginalised in these fields. We propose the haunted curriculum as an evocative conceptual framing to engage with the aspects of medical and HPE that are toxic and troubling to learners and to understand how violent histories continue to loom large and permeate the present. The haunted curriculum examines how forms of oppression and injustice, such as racism and ableism, are always ever‐present and often arise in unexpected ways during training. The haunted curriculum also helps to uncover how environments of training and professionalisation may themselves inflict these forms of oppression and injustice and may be ideal spaces to counter them. [ABSTRACT FROM AUTHOR]

Transcultural psychiatry was developed in France to promote cultural and linguistic diversity and address the mental health needs of immigrants who were excluded from accessing other public mental health services. Professionals in health and social services refer patients to transcultural psychiatry consultations when miscommunications arise or when professionals determine that patients need culturally sensitive therapy. In transcultural psychiatry consultations, a group of therapists, composed primarily of psychologists and psychiatrists, as well as other health and social service professionals, receives a patient, the patient's family, and referring professionals. Previous research on transcultural psychiatry has emphasized the importance of culturally diverse therapy teams and the ways that therapists' diversity could permit patients to open up in consultation sessions. This study draws on ethnographic research in two transcultural psychiatry consultations in Île-de-France, and pays particular attention to the experiences of apprentice therapists, who were often graduate students in clinical psychology. Apprentice therapists reported being introduced to patients in ways that they would not choose themselves. As a result, therapists felt that they had to overemphasize their cultures or countries of origin and French therapists questioned their place in the group. This article describes how transcultural therapy groups are a theater in which belonging, identity, and Frenchness are contested and performed. Apprentice therapists proposed more intersectional and inclusive ways of portraying diversity in the transcultural groups. [ABSTRACT FROM AUTHOR]

Saiba Varma's I The Occupied Clinic: Militarism and Care in Kashmir i - 2021 winner of the Edie Turner First Book Award - is a brilliant and gripping ethnographic analysis of psychiatric care in response to an epidemic of trauma and a burgeoning field of psychiatry in Indian-occupied Kashmir. Clinicians, undergraduate students, and anyone curious about the fraught translation between biomedical psychiatry and local contexts of suffering will greatly appreciate Varma's dexterous and generous ethnography. While some psychiatrists consider ECT without anesthesia to be better than no treatment at all, for many patients, shock was a form of torture frequently used as an interrogation technique on Kashmiris. [Extracted from the article]

This paper discusses progressive thinking and clinical views on improving mental health practice for immigrants and refugees. It addresses policy, care delivery, professionals' attitudes, and immigrants' access to mental health care -- all factors especially pertinent for practice in major immigration hubs. The data was gathered from invited presentations and discussions among participants at an international multidisciplinary symposium, including health and social scientists from Toronto (Canada) and Paris (France), major urban centres attracting large numbers of immigrant and refugees who constantly encounter challenges for their successful settlement. The focus is on alternative care thinking and innovative approaches for better care and understanding of these populations' health behavior. Recommendations on how to advance knowledge relevant for these two urban hubs of immigration were documented, underpinned by the consensus that economic disparities, societal and political forces, as well as cultural and linguistic factors, influence immigrants' and refugees' vulnerability regarding mental health stability. [ABSTRACT FROM AUTHOR]

Background: Basiliximab and anti-thymocyte globulin are widely used drugs for induction therapy after pediatric heart transplantation. The aim of this study was to determine whether any differences could be observed between basiliximab and anti-thymocyte globulin, with respect to long-term mortality, in a population of pediatric cardiac transplant recipients., Methods and Results: An analysis of pediatric heart transplant patients (aged <18 years) from the United Network for Organ Sharing database was conducted that compared patients receiving basiliximab with those that received anti-thymocyte globulin for the risk of all-cause mortality. Secondary endpoints included death attributable to graft failure, cardiovascular causes, infection, or malignancy. Of the 2275 patients, 685 received basiliximab and 1590 anti-thymocyte globulin. One-year survival was similar for both groups; however, at 5 and 10 years, basiliximab was associated with poorer long-term survival (68% versus 76% at 5 years [P<0.001] and 49% versus 65% at 10 years [P<0.001], respectively). Basiliximab was associated with higher risk of death attributable to graft failure (P=0.013), but not death attributable to cardiovascular causes (P=0.444), infection (P=0.095), or malignancy (P=0.392). After multivariate analysis, use of basiliximab (versus use of anti-thymocyte globulin) remained significantly associated with all-cause mortality (hazard ratio, 1.27; 95% confidence interval, 1.02-1.57; P=0.030)., Conclusions: In pediatric heart transplant patients, use of basiliximab for induction therapy was associated with an increased risk of mortality, when compared with those receiving anti-thymocyte globulin., (© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.)

The connection between pancreatic cancer and venous thrombosis has been discussed for almost 150 years. The exact pathophysiological mechanisms are still partly understood, but it is known that pancreatic cancer induces a prothrombotic and hypercoagulable state and genetic events involved in neoplastic transformation (e.g., KRAS, c-MET, p53), procoagulant factors [e.g., tissue factor (TF), platelet factor 4 (PF4), plasminogen activator inhibitor type 1 (PAI-1)], mucin production (e.g., through activation of P- and L-selectin) and pro-inflammatory factors [e.g., cytokines, cyclooxygenase-2 (COX-2)] may be implicated. Also pancreatitis, both acute and chronic, is associated with increased risk of venous thrombosis, but in this circumstance a direct inflammatory process may be more important. This article discusses the incidence, treatment and outcome of venous thromboembolism (VTE) complicating pancreatic disease, with special emphasis on new knowledge obtained during the last fifteen years.

Long-term treatment of mouse cancer cells with interferon-alpha (IFN-alpha) converts parental B16 melanoma cells to B16alpha vaccine cells. Inoculation of syngeneic mice with UV-irradiated B16alpha vaccine cells triggers immunity to the parental B16 tumor that is mediated by host macrophages, T cells, and NK cells. Lymph node cells from mice inoculated with irradiated B16alpha vaccine cells, but not with irradiated parental cells, proliferate when cultured in vitro, suggesting long-term in vivo activation of lymphoid cells. Both IL-15 mRNA and IL-15 protein are highly induced in B16alpha vaccine cells. The bulk of the induced IL-15 is shown to be cell-associated, either cytoplasmic or membranous. The current study investigated the feasibility of applying the B16alpha vaccination protocol to generate a cancer vaccine against murine RM-1 prostate carcinoma. In comparison to B16alpha vaccine cells, long-term IFN-alpha-treated RM-1 cells (RM-1alpha vaccine cells) showed significant IL-15 mRNA induction but relatively low IL-15 protein up-regulation. When UV-irradiated, a 3-fold increase in intracellular IL-15 was observed in RM-1alpha vaccine cells, suggesting UV damage may have negated a possible control mechanism for IL-15 synthesis. Efficacy of in vivo vaccination of syngeneic mice with UV-irradiated RM-1alpha and B16alpha vaccine cells showed correlation between high IL-15 level and high vaccine efficacy in B16alpha cells compared to low IL-15 level and low vaccine efficacy in RM-1alpha cells. This supports the concept that the induction of IL-15 in tumor cells can be useful for creating whole-cell cancer vaccines.