1. Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells
- Author
-
Patrick Htun, Konstantinos Stellos, Boris Bigalke, Dimitrios Stakos, Peter Seizer, Iris Müller, Annika Schad, Florian Pfaff, Stephan Lindemann, Meinrad Gawaz, Harald F. Langer, Andreas Kögel, and Tobias Geisler
- Subjects
Blood Platelets ,Male ,Acute coronary syndrome ,medicine.medical_specialty ,CD34 ,Antigens, CD34 ,Cell Count ,Coronary artery disease ,Ventricular Dysfunction, Left ,Internal medicine ,medicine ,Humans ,Platelet ,Platelet activation ,Acute Coronary Syndrome ,Progenitor cell ,Aged ,Aged, 80 and over ,business.industry ,Stroke Volume ,Middle Aged ,Hematopoietic Stem Cells ,Platelet Activation ,medicine.disease ,Chemokine CXCL12 ,Haematopoiesis ,Endocrinology ,Immunology ,Female ,GPVI ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Aims Previous experimental studies have suggested that platelet stromal-cell-derived factor-1 (SDF-1) regulates mobilization and recruitment of haematopoietic progenitor cells supporting revascularization in mice. However, there are no clinical data available regarding platelet-bound SDF-1 in patients with acute coronary syndrome (ACS). The objective of this study was to evaluate the platelet-surface expression of SDF-1 in patients with ACS. Methods and results Patients with ACS ( n = 418) showed a significantly enhanced SDF-1 expression on admission compared with those with stable angina pectoris (SAP, n = 486) [SAP (mean fluorescence intensity (MFI) ± SD): 13.48 ± 5.27; ACS: 18.45 ± 12.85; P < 0.001) independent of cardiovascular risk factors and medication. Enhanced platelet-bound SDF-1 expression was found in patients with reduced left ventricular ejection fraction (LVEF
- Published
- 2009
- Full Text
- View/download PDF