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3. Association Between All-Cause Mortality and High-Sensitivity Cardiac Troponin Concentrations in Patients With Chest Pain.

Author

Annie, Frank H., Kepfinger, Joshua, Ahmed, Fatima, Pervez, Muhammad Ijaz, and Elashery, Ahmad

Subjects
*CHEST pain diagnosis, *TROPONIN, *RISK assessment, *PREDICTIVE tests, *CHEST pain, *RESEARCH funding, *PROBABILITY theory, *HOSPITAL emergency services, *CAUSES of death, *DESCRIPTIVE statistics, *LONGITUDINAL method, *BIOMARKERS, MORTALITY risk factors
Abstract

We assessed the association between troponin levels and all-cause mortality in individuals with chest pain who presented to the Charleston Area Medical Center Emergency Department (CAMC). We identified adult patients with chest pain as defined in the International Classification of Diseases 10 (R07) family group from the CAMC data warehouse between June 6, 2020, and June 6, 2021. These cases required a visit to the emergency room. We created 3 different cohorts to assess the endpoints of all-cause mortality at 30 days and 6 months. Patients were divided into the following 3 categories: negative troponin level, defined as high sensitivity troponin I (HSTNI) assay ≤15 pg/mL for women and ≤20 pg/mL for men; weakly positive, 21–88 pg/mL for men and 16–88 pg/mL for women; and strongly positive, >88 pg/mL for men and women. A propensity score matching analysis was also conducted using the negative group as a control; the weakly and strongly positive groups were compared to the control across differing cardiology covariates. This study introduces novel cutoffs for high-sensitivity troponin I (Beckman Coulter assay, Beckman Coulter, Inc., Chaska Campus, 1000 Lake Hazeltine Drive, Chaska, Minnesota 55318). [ABSTRACT FROM AUTHOR]

Published
2024
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4. Severe familial dilated cardiomyopathy in a young adult due to a rare LMNA mutation: a case report.

Author

Belcher, Adam M, Annie, Frank H, Rinehart, Sarah, Elashery, Ahmad, and Amer, Muhammad

Subjects
DILATED cardiomyopathy, YOUNG adults, EMERGENCY room visits, BUNDLE-branch block, PROGNOSIS, BRUGADA syndrome
Abstract

Background Familial dilated cardiomyopathy prognosis and disease progression vary greatly depending upon the type of genetic mutation. Family history and genetic testing are paramount in developing the best treatment plan for a patient. However, with rare or novel mutations, the significance may be unknown. Regarding this, the following case report highlights the importance of vigilance and suspicion when treating a patient with a variant of unknown significance. Additionally, it shows the importance of thoroughly investigating the family history of cardiovascular disease. Case summary A 25-year-old Caucasian male was found to have a right bundle branch block and dilated cardiomyopathy upon presentation to the emergency department. Later testing showed that the dilated cardiomyopathy was due to an incredibly rare lamin A/C (LMNA) gene mutation, R349L. Despite treatment with a maximum-tolerable medication regimen and an automatic implantable cardioverter-defibrillator, the patient continued to decline and required a heart transplant. Discussion This case provides more information on the severity of this specific LMNA mutation that has only been documented once before. Of note, the time from the initial emergency department visit to the heart transplant was approximately 2 years. Given the patient's young age and rapid disease progression, in addition to a strong family history of sudden cardiac death, the significance of this mutation should not be understated. The additional knowledge gained from this case report can be used to aid in timely interventions and prognosis evaluation. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Steep rise in drug use-associated infective endocarditis in West Virginia: Characteristics and healthcare utilization

Author

Bhandari, Ruchi, primary, Alexander, Talia, additional, Annie, Frank H., additional, Kaleem, Umar, additional, Irfan, Affan, additional, Balla, Sudarshan, additional, Wiener, R. Constance, additional, Cook, Chris, additional, Nanjundappa, Aravinda, additional, Bates, Mark, additional, Thompson, Ellen, additional, Smith, Gordon S., additional, Feinberg, Judith, additional, and Fisher, Melanie A., additional

Published
2022
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27. Sex Differences in Characteristics of Patients with Infective Endocarditis: A Multicenter Study

Author

Bhandari, Ruchi, primary, Tiwari, Shabnam, additional, Alexander, Talia, additional, Annie, Frank H., additional, Kaleem, Umar, additional, Irfan, Affan, additional, Balla, Sudarshan, additional, Wiener, R. Constance, additional, Cook, Chris, additional, Nanjundappa, Aravinda, additional, Bates, Mark, additional, Thompson, Ellen, additional, Smith, Gordon S., additional, Feinberg, Judith, additional, and Fisher, Melanie A., additional

Published
2022
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