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3. Micro‐ and Nano‐Structured Bacteria Growth Media for Planar Bio‐Photonics

Author

Caligiuri, Vincenzo, primary, Leone, Francesca, additional, Favale, Olga, additional, De Santo, Maria, additional, Bruno, Mauro Daniel Luigi, additional, Mileti, Olga, additional, Pane, Alfredo, additional, Patra, Aniket, additional, Petti, Lucia, additional, Guzman‐Puyol, Susana, additional, Heredia‐Guerrero, José Alejandro, additional, Krahne, Roman, additional, Baldino, Noemi, additional, Bartolino, Roberto, additional, Galluccio, Michele, additional, Annesi, Ferdinanda, additional, and De Luca, Antonio, additional

Published
2023
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4. Micro‐ and Nano‐Structured Bacteria Growth Media for Planar Bio‐Photonics.

Author

Caligiuri, Vincenzo, Leone, Francesca, Favale, Olga, De Santo, Maria, Bruno, Mauro Daniel Luigi, Mileti, Olga, Pane, Alfredo, Patra, Aniket, Petti, Lucia, Guzman‐Puyol, Susana, Heredia‐Guerrero, José Alejandro, Krahne, Roman, Baldino, Noemi, Bartolino, Roberto, Galluccio, Michele, Annesi, Ferdinanda, and De Luca, Antonio

Subjects
PHOTONIC crystals, BIOMATERIALS, BACTERIAL growth, QUASICRYSTALS, BACTERIA, QUANTUM optics
Abstract

Bio‐inspired and biodegradable quantum optics scenarios constitute a pathway toward environmentally friendly front‐end technologies. Such an inspiring perspective necessitates the replacement of classic gain materials with a biological counterpart like photoluminescent bacteria. It is easy to imagine that, in this case, a planar and cell‐viable substitute of classic bulk solid‐states resonators can be highly beneficial. In this paper a micro‐ and nano‐photonic structuration of both a standard and a functionalized version of a typical bacterial growth medium (Luria‐Bertani Agar – LBA) is successfully realized. Three structures belonging to the categories of photonic crystals are replicated, such as quasi‐crystals and meta‐surfaces, demonstrating how the proposed media can be used as templates for high‐end photonic applications. The optical quality of the replicated structures is confirmed by far‐field diffraction measurements. The structured growth media allow for a broad control of the surface wettability by accessing a so‐called Wenzel state, in which the original hydrophilicity of a material is increased due to the photonic structuration. Finally, the suitability of the nano‐structured LBA as a plasmonic platform is evidenced. The proposed micro‐and nano‐structured photonic growth media constitute the first, fundamental step toward quantum optical frameworks from biological media. [ABSTRACT FROM AUTHOR]

Published
2024
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5. List of Contributors

Author

Almeida, Ana P.C., primary, Alothman, Othman, additional, Annamalai, Pratheep K., additional, Annesi, Ferdinanda, additional, Ates, Burhan, additional, Balcioglu, Sevgi, additional, Baptista, Ana C., additional, Bartolino, Roberto, additional, Behranvand, Vajiheh, additional, Bhanvase, Bharat A., additional, Borges, João P., additional, Chin, Wee S., additional, Claussen, Jonathan C., additional, Comparelli, Roberto, additional, Curri, Maria L., additional, Daniele, Michael A., additional, De Sio, Luciano, additional, Echeverria, Coro, additional, Fernandes, Susete N., additional, Garland, Nathaniel T., additional, Godinho, Maria H., additional, Gomes, Carmen, additional, Gurses, Canbolat, additional, Jawaid, Mohammad, additional, João, Carlos F.C., additional, Koledintseva, Marina Y., additional, Koytepe, Suleyman, additional, Kyaw, Aung K.K., additional, Mallakpour, Shadpour, additional, Marrow, Ethan A., additional, McLamore, Eric S., additional, Medintz, Igor L., additional, Mutsuyoshi, Hiroshi, additional, Nguyen, Hai, additional, Pane, Alfredo, additional, Placido, Tiziana, additional, Ramanujam, B.T.S., additional, Rashidimoghadam, Shima, additional, Rozanov, Konstantin N., additional, Saba, Naheed, additional, Silva, Jorge C., additional, Soares, Paula I.P., additional, Sonawane, Shirish H., additional, Stergiou, Charalampos A., additional, Sultan, Mohamed Thariq Hameed, additional, Tang, Youhong, additional, Ulu, Ahmet, additional, Umeton, Cesare, additional, Walper, Scott, additional, Xu, Jianwei, additional, Ye, Qun, additional, Yemata, Temesgen A., additional, Zatar, Wael, additional, Zhang, Hong-ping, additional, and Zhou, Hui, additional

Published
2017
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6. Liquid crystalline DNA

Author

De Sio, Luciano, primary, Annesi, Ferdinanda, additional, Placido, Tiziana, additional, Comparelli, Roberto, additional, Pane, Alfredo, additional, Curri, Maria L., additional, Umeton, Cesare, additional, and Bartolino, Roberto, additional

Published
2017
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11. Generalized epilepsy with febrile seizures plus: Clinical and genetic analysis of three Serbian families

Author

Ristić Aleksandar J., Janković Slavko, Annesi Grazzia, Carrideo Sara, Annesi Ferdinanda, Gambardella Antonio, Maksimović Goran, Gnjatović Brankica, Petrović Igor, Vojvodić Nikola, and Sokić Dragoslav

Subjects
genetics, inherited epilepsy, generalized epilepsy with febrile seizures plus (GEFS+), Serbian population, Medicine
Abstract

The results of clinical and genetic analysis of three Serbian families (pedigrees) with autosomal dominant inheritance, incomplete penetrance and phenotypic features of GEFS+ are presented in this study. Mutation analysis of the SCN1A, SCN1B and GABRG2 genes was performed in all affected and some unaffected members of these three families. Twentysix exons of SCN1A, five exons of SCN1B and nine exons of GABRG2 were individually amplified using primers based on intronic sequence. PCR products were sequenced in both forward and reverse directions. Subsequently, the samples were run and analyzed using 377 DNA automated sequencer. No consanguinity was noticed. The MM and OM family members live in Republic of Srpska while KS family originates from the central Serbia. No mutations of the exons of SCN1A, SCN1B and GABRG2 genes were found in tested subjects. Obligate carriers in MM family (III-1, III-2, and III-4) exhibit variable expressivity or incomplete penetrance rather than proof of polygenetic inheritance. OM pedigree follows autosomal dominant pattern despite reduced penetrance. Bilinear transmission may assume the possibility of multigenetic mode of inheritance in KS family. The fact that all affected members in three Serbian families were negative for mutations in SCN1A, SCN1B and GABRG2 genes strongly supports the hypothesis of significant genetic heterogeneity of GEFS+. Recognizing GEFS+ on clinical grounds contributes to more precise integration of this syndrome into already existing classification of epileptic syndromes.

Published
2005
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12. Thermal Liquid Biopsy (TLB) of Blood Plasma as a Potential Tool to Help in the Early Diagnosis of Multiple Sclerosis

Author

Annesi, Ferdinanda, primary, Hermoso-Durán, Sonia, additional, Rizzuti, Bruno, additional, Bruno, Rosalinda, additional, Pirritano, Domenico, additional, Petrone, Alfredo, additional, Del Giudice, Francesco, additional, Ojeda, Jorge, additional, Vega, Sonia, additional, Sanchez-Gracia, Oscar, additional, Velazquez-Campoy, Adrian, additional, Abian, Olga, additional, and Guzzi, Rita, additional

Published
2021
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13. Identification of an [Na.sub.v]1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures

Author

Mantegazza, Massimo, Gambardella, Antonio, Rusconi, Raffaella, Schiavon, Emanuele, Annesi, Ferdinanda, Cassulini, Rita Restano, Labate, Angelo, Carrideo, Sara, Chifari, Rosanna, Canevini, Maria Paola, Canger, Raffaele, Franceschetti, Silvana, Annesi, Grazia, Wanke, Enzo, and Quattrone, Aldo

Subjects
Febrile convulsions -- Health aspects, Children -- Health aspects, Children -- Research, Science and technology
Abstract

Febrile seizures (FS) affect 5-12% of infants and children up to 6 years of age. There is now epidemiological evidence that FS are associated with subsequent afebrile and unprovoked seizures in [approximately equal to] 7% of patients, which is 10 times more than in the general population. Extensive genetic studies have demonstrated that various loci are responsible for familial FS, and the FEB3 autosomal-dominant locus has been identified on chromosome 2q23-24, where the SCN1A gene is mapped. However, gene mutations causing simple FS have not been found yet. Here we show that the M145T mutation of a well conserved amino acid in the first transmembrane segment of domain I of the human [Na.sub.v]1.1 channel s-subunit cosegregates in all 12 individuals of a large Italian family affected by simple FS. Functional studies in mammalian cells demonstrate that the mutation causes a 60% reduction of current density and a 10-mV positive shift of the activation curve. Thus, M145T is a loss-of-function mutant. These results show that monogenic FS should also be considered a channelopathy. channelopathy | FEB3 locus | convulsions | epilepsy | neuronal excitability

Published
2005

14. Association study between four polymorphisms in the HFE, TF and TFR genes and Parkinson’s disease in Southern Italy

Author

Greco, Valentina, De Marco, Elvira Valeria, Rocca, Francesca Emanuela, Annesi, Ferdinanda, Civitelli, Donatella, Provenzano, Giovanni, Tarantino, Patrizia, Scornaienchi, Vittorio, Pucci, Franco, Salsone, Maria, Novellino, Fabiana, Morelli, Maurizio, Paglionico, Sandra, Gambardella, Antonio, Quattrone, Aldo, and Annesi, Grazia

Published
2011
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17. Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinsonʼs disease

Author

Quattrone, Aldo, Bagnato, Antonio, Annesi, Grazia, Novellino, Fabiana, Morgante, Letterio, Savettieri, Giovanni, Zappia, Mario, Tarantino, Patrizia, Candiano, Innocenza Claudia Cirò, Annesi, Ferdinanda, Civitelli, Donatella, Rocca, Francesca Emanuela, DʼAmelio, Marco, Nicoletti, Giuseppe, Morelli, Maurizio, Petrone, Alfredo, Loizzo, Piercostanzo, and Condino, Francesca

Published
2008
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19. Mutational Analysis of EFHC1 Gene in Italian Families with Juvenile Myoclonic Epilepsy

Author

Annesi, Ferdinanda, Gambardella, Antonio, Michelucci, Roberto, Bianchi, Amedeo, Marini, Carla, Canevini, Maria Paola, Capovilla, Giuseppe, Elia, Maurizio, Buti, Daniela, Chifari, Rosanna, Striano, Pasquale, Rocca, Francesca E., Castellotti, Barbara, Cali, Francesco, Labate, Angelo, LePiane, Emilio, Besana, Dante, Sofia, Vito, Tabiadon, Giulietta, Tortorella, Gaetano, Vigliano, Piernanda, Vignoli, Aglaia, Beccaria, Francesca, Annesi, Grazia, Striano, Salvatore, Aguglia, Umberto, Guerrini, Renzo, and Quattrone, Aldo

Published
2007

24. Two Novel SCN1A Missense Mutations in Generalized Epilepsy with Febrile Seizures Plus

Author

Annesi, Grazia, Gambardella, Antonio, Carrideo, Sara, Incorpora, Gemma, Labate, Angelo, Pasqua, Angela Aurora, Civitelli, Donatella, Polizzi, Agata, Annesi, Ferdinanda, Spadafora, Patrizia, Tarantino, Patrizia, Candiano, Innocenza C. Cirò, Romeo, Nelide, De Marco, Elvira Valeria, Ventura, Patrizia, LePiane, Emilio, Zappia, Mario, Aguglia, Umberto, Pavone, Lorenzo, and Quattrone, Aldo

Published
2003

25. Thermo-Plasmonic Killing of Escherichia coli TG1 Bacteria

Author

Annesi, Ferdinanda, primary, Pane, Alfredo, additional, Losso, Maria Adele, additional, Guglielmelli, Alexa, additional, Lucente, Fabrizio, additional, Petronella, Francesca, additional, Placido, Tiziana, additional, Comparelli, Roberto, additional, Guzzo, Maria Grazia, additional, Curri, Maria Lucia, additional, Bartolino, Roberto, additional, and De Sio, Luciano, additional

Published
2019
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28. Liquid crystalline DNA: A smart polymer with a variety of applications ranging from photonics to plasmonics

Author

De Sio, Luciano, Annesi, Ferdinanda, Placido, Tiziana, Comparelli, Roberto, Pane, Alfredo, Curri, Maria L., Umeton, Cesare, and Bartolino, Roberto

Subjects
Holography, Plasmonics, sense organs, DNA, eye diseases, Nanomaterials
Abstract

13.1 Deoxyribonucleic acid 13.1.1 DNA and its liquid crystalline phases 13.1.2 DNA extraction 13.1.3 Agarose gel electrophoresis analysis 13.1.4 DNA labeling 13.2 Plasmonic nanoparticles 13.3 Liquid crystalline DNA organization in polymeric template 13.4 Gold nanorods organized in liquid crystalline DNA 13.5 Conclusion

Published
2017

30. Photo-thermal effects in gold nanorods/DNA complexes

Author

De Sio, Luciano, primary, Caracciolo, Giulio, additional, Annesi, Ferdinanda, additional, Placido, Tiziana, additional, Pozzi, Daniela, additional, Comparelli, Roberto, additional, Pane, Alfredo, additional, Curri, Maria Lucia, additional, Agostiano, Angela, additional, and Bartolino, Roberto, additional

Published
2016
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31. Mutation analysis of the PINK1 gene in Southern Italian patients with early- and late-onset parkinsonism

Author

Scornaienchi, Vittorio, Civitelli, Donatella, De Marco, Elvira V., Annesi, Grazia, Tarantino, Patrizia, Rocca, Francesca E., Greco, Valentina, Provenzano, Giovanni, Annesi, Ferdinanda, Nicoletti, Giuseppe, Colica, Carmela, Uncini, Antonino, Salsone, Maria, Novellino, Fabiana, Morelli, Maurizio, Arabia, Gennarina, Gambardella, Antonio, and Quattrone, Aldo

Published
2012
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32. Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

Author

Ross, Owen A, Soto-Ortolaza, Alexandra I, Brighina, Laura, Riess, Olaf, Klein, Christine, Djarmati, Ana, Hagenah, Johann, Lohmann, Katja, van de Loo, Simone, Abahuni, Nadine, Gispert-Sánchez, Suzana, Hilker, Rüdiger, Auburger, Georg, Van Broeckhoven, Christine, Xiromerisiou, Georgia, Tsimourtou, Vaia, Ralli, Styliani, Kountra, Persa, Markou, Katerina, Patramani, Gianna, Vogiatzi, Christina, Lynch, Tim, Gibson, J Mark, Craig, Dr David, Carr, Jonathan, Valente, Enza Maria, Ferraris, Alessandro, Bentivoglio, Anna Rita, Ialongo, Tamara, Guidubaldi, Arianna, Piano, Carla, Ferrarese, Carlo, Tarantino, Patrizia, Annesi, Ferdinanda, Chartier-Harlin, Marie-Christine, Annesi, Grazia, Quattrone, Aldo, Hattori, Nobutaka, Tomiyama, Hiroyuki, Funayama, Manabu, Yoshino, Hiroyo, Li, Yuanzhe, Imamichi, Yoko, Toda, Tatsushi, Satake, Wataru, Dardiotis, Efthimios, Aasly, J., Opala, Grzegorz, Jasinska-Myga, Barbara, Boczarska-Jedynak, Magdalena, Tan, Eng King, Bardien, Soraya, Jeon, Beom Seok, Park, Sung Sup, Kim, Yun Joong, Dickson, Dennis W, Sohn, Young Ho, Belin, Andrea Carmine, Olson, Lars, Galter, Dagmar, Westerlund, Marie, Sydow, Olof, Pedersen, Nancy L, Wirdefeldt, Karin, Nilsson, Christer, Puschmann, Andreas, Diehl, Nancy N, Wu, Ruey-Meei, Maraganore, Demetrius M, Ahlskog, Eric, de Andrade, Mariza, Lesnick, Timothy G, Rocca, Walter A, Checkoway, Harvey, Farrer, M., Elbaz, Alexis, Heckman, Michael G, Fiske, Brian, Gibson, Rachel, Hadjigeorgiou, Georgios M, Ioannidis, John P A, Jeon, Beom S, Aasly, Jan O, Kruger, Rejko, Kyratzi, Elli, Lesage, Suzanne, Lin, Chin-Hsien, Lynch, Timothy, Mellick, George D, Mutez, Eugénie, Sharma, Manu, Silburn, Peter A, Stefanis, Leonidas, Tadic, Vera, Theuns, Jessie, Uitti, Ryan J, Vassilatis, Demetrios K, Vilariño-Güell, Carles, White, Linda R, Wszolek, Zbigniew K, Farrer, Matthew J, Bacon, Justin A, Disease, Genetic Epidemiology Of Parkinson's, Sutherland, G. T., Siebert, G. A., Nuytemans, Karen, Meeus, Bram, Crosiers, David, Pickut, Barbara, Engelborghs, Sebastiaan, De Deyn, Peter P, Cras, Patrick, Rogaeve, Ekaterina, Destée, A., Agid, Y., Anheim, M., Bonnet, A-M, Borg, M., Bozi, Maria, Brice, A., Broussolle, E., Corvol, J. C., Damier, P., Dürr, A., Durif, F., Lesage, S., Lohmann, E., Pollak, P., Brice, Alexis, Rascol, O., Tison, F., Tranchant, C., Viallet, F., Vidailhet, M., Gasser, Thomas, Krüger, Rejko, Berg, Daniela, Schulte, Claudia, Ross, O, Soto Ortolaza, A, Heckman, M, Aasly, J, Abahuni, N, Annesi, G, Bacon, J, Bardien, S, Bozi, M, Brice, A, Brighina, L, Van Broeckhoven, C, Carr, J, Chartier Harlin, M, Dardiotis, E, Dickson, D, Diehl, N, Elbaz, A, Ferrarese, C, Ferraris, A, Fiske, B, Gibson, J, Gibson, R, Hadjigeorgiou, G, Hattori, N, Ioannidis, J, Jasinska Myga, B, Jeon, B, Kim, Y, Klein, C, Kruger, R, Kyratzi, E, Lesage, S, Lin, C, Lynch, T, Maraganore, D, Mellick, G, Mutez, E, Nilsson, C, Opala, G, Park, S, Puschmann, A, Quattrone, A, Sharma, M, Silburn, P, Sohn, Y, Stefanis, L, Tadic, V, Theuns, J, Tomiyama, H, Uitti, R, Valente, E, van de Loo, S, Vassilatis, D, Vilariño Güell, C, White, L, Wirdefeldt, K, Wszolek, Z, Wu, R, Farrer, M, Engelborghs, Sebastiaan, De Deyn, Peter Paul, Cras, Patrick, Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium, Pathologic Biochemistry and Physiology, and Pollak, Pierre

Subjects
Male, Polymorphism, Single Nucleotide/*genetics, International Cooperation, Ethnic Groups/genetics, Ethnic Group, Genome-wide association study, Protein-Serine-Threonine Kinase, methods [Genome-Wide Association Study], genetics [Ethnic Groups], 0302 clinical medicine, Gene Frequency, genetics [Parkinson Disease], Risk Factors, Exons/genetics, Ethnicity, Parkinson Disease/genetics, Medicine(all), Genetics, Aged, 80 and over, 0303 health sciences, Parkinson Disease, Exons, genetics [Exons], Middle Aged, Polymorphism, Single Nucleotide/genetics, Protein-Serine-Threonine Kinases, LRRK2, 3. Good health, genetics [Polymorphism, Single Nucleotide], Genome-Wide Association Study/methods, Female, Case-Control Studie, Human, Adult, Parkinson Disease/*genetics, Genotype, Adolescent, Protein-Serine-Threonine Kinases/*genetics, Protein-Serine-Threonine Kinases/genetics, Exon, Protein Serine-Threonine Kinases, Biology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, genetics [Protein-Serine-Threonine Kinases], Polymorphism, Single Nucleotide, 03 medical and health sciences, Young Adult, Humans, Genetic Predisposition to Disease, ddc:610, LRRK2 protein, human, Risk factor, Allele frequency, 030304 developmental biology, Aged, Risk Factor, Case-control study, Exons/*genetics, Odds ratio, nervous system diseases, ddc:616.8, Minor allele frequency, Genetic epidemiology, Case-Control Studies, Neurology (clinical), Human medicine, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

BACKGROUND: Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the variants in PD susceptibility. METHODS: LRRK2 was genotyped in patients with PD and controls from three series (white, Asian, and Arab-Berber) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Genotyping was done for exonic variants of LRRK2 that were identified through searches of literature and the personal communications of consortium members. Associations with PD were assessed by use of logistic regression models. For variants that had a minor allele frequency of 0.5% or greater, single variant associations were assessed, whereas for rarer variants information was collapsed across variants. FINDINGS: 121 exonic LRRK2 variants were assessed in 15 540 individuals: 6995 white patients with PD and 5595 controls, 1376 Asian patients and 962 controls, and 240 Arab-Berber patients and 372 controls. After exclusion of carriers of known pathogenic mutations, new independent risk associations were identified for polymorphic variants in white individuals (M1646T, odds ratio 1.43, 95% CI 1.15-1.78; p=0.0012) and Asian individuals (A419V, 2.27, 1.35-3.83; p=0.0011). A protective haplotype (N551K-R1398H-K1423K) was noted at a frequency greater than 5% in the white and Asian series, with a similar finding in the Arab-Berber series (combined odds ratio 0.82, 0.72-0.94; p=0.0043). Of the two previously reported Asian risk variants, G2385R was associated with disease (1.73, 1.20-2.49; p=0.0026), but no association was noted for R1628P (0.62, 0.36-1.07; p=0.087). In the Arab-Berber series, Y2189C showed potential evidence of risk association with PD (4.48, 1.33-15.09; p=0.012). INTERPRETATION: The results for LRRK2 show that several rare and common genetic variants in the same gene can have independent effects on disease risk. LRRK2, and the pathway in which it functions, is important in the cause and pathogenesis of PD in a greater proportion of patients with this disease than previously believed. These results will help discriminate those patients who will benefit most from therapies targeted at LRRK2 pathogenic activity. FUNDING: Michael J Fox Foundation and National Institutes of Health. Lancet Neurol

Published
2011

33. Independent and joint effects of the MAPT and SNCA genes in Parkinson disease

Author

Elbaz, Alexis, Ross, Owen A, Destée, Alain, Ferrarese, Carlo, Ferraris, Alessandro, Gibson, J Mark, Gispert, Suzana, Hadjigeorgiou, Georgios M, Jasinska-Myga, Barbara, Klein, Christine, Krüger, Rejko, Lambert, Jean-Charles, Ioannidis, John P A, Lohmann, Katja, van de Loo, Simone, Loriot, Marie-Anne, Lynch, Timothy, Mellick, George D, Mutez, Eugénie, Nilsson, Christer, Opala, Grzegorz, Puschmann, Andreas, Quattrone, Aldo, Soto-Ortolaza, Alexandra I, Sharma, Manu, Silburn, Peter A, Stefanis, Leonidas, Uitti, Ryan J, Valente, Enza Maria, Vilariño-Güell, Carles, Wirdefeldt, Karin, Wszolek, Zbigniew K, Xiromerisiou, Georgia, Maraganore, Demetrius M, Moisan, Frédéric, Farrer, Matthew J, Disease, Genetic Epidemiology of Parkinson's, Amouyel, Philippe, Tzourio, Christophe, Mulot, Claire, Bacon, Justin A, Cobb, Stephanie A, Sutherland, Greg T, Siebert, Gerhard A, Dissanayaka, Nadeeka, Aasly, Jan, O'Sullivan, John D, Boyle, Richard S, Pasquier, Florence, Bordet, Régis, Legendre, Jean-Philippe, Auburger, Georg, Hilker, Rüdiger, Abahuni, Nadine, Geisen, Christof, Winkler, Susen, Annesi, Grazia, Gasser, Thomas, Riess, Olaf, Berg, Daniela, Schulte, Claudia, Vassilatis, Demitris, Stamboulis, Eleftherios, Dardiotis, Efthimios, Patramani, Ioanna, Kountra, Persa-Maria, Vogiatzi, Christina, Bozi, Maria, Markou, Katerina, Tarantino, Patrizia, Annesi, Ferdinanda, Bentivoglio, Anna Rita, Guidubaldi, Arianna, Caccialupi, Matilde, De Nigris, Francesca, Riva, Chiara, Pedersen, Nancy L, Nilsson, Karin, Brighina, Laura, Reimer, Jan, Van Gerpen, Jay, Lash, Jennifer, Searcy, Jill, Strongosky, Audrey, Chartier-Harlin, Marie-Christine, Elbaz, A, Ross, O, Ioannidis, J, Soto Ortolaza, A, Moisan, F, Aasly, J, Annesi, G, Bozi, M, Brighina, L, Chartier Harlin, M, Destée, A, Ferrarese, C, Ferraris, A, Gibson, J, Gispert, S, Hadjigeorgiou, G, Jasinska Myga, B, Klein, C, Krüger, R, Lambert, J, Lohmann, K, van de Loo, S, Loriot, M, Lynch, T, Mellick, G, Mutez, E, Nilsson, C, Opala, G, Puschmann, A, Quattrone, A, Sharma, M, Silburn, P, Stefanis, L, Uitti, R, Valente, E, Vilariño Güell, C, Wirdefeldt, K, Wszolek, Z, Xiromerisiou, G, Maraganore, D, and Farrer, M

Subjects
Adult, Male, Parkinson Disease/*genetics, Logistic Model, Polymorphism, Single Nucleotide/*genetics, Single-nucleotide polymorphism, Genome-wide association study, MAPT protein, human, tau Proteins, Biology, alpha-Synuclein/*genetics, Polymorphism, Single Nucleotide, Article, Gene interaction, genetics [Parkinson Disease], Retrospective Studie, Genotype, Odds Ratio, SNP, Humans, genetics, Genetic Predisposition to Disease, ddc:610, SNCA protein, human, Age of Onset, Retrospective Studies, Aged, Genetics, Aged, 80 and over, Haplotype, tau Protein, Parkinson Disease, Middle Aged, genetics [tau Proteins], Settore MED/26 - NEUROLOGIA, Logistic Models, Neurology, Genetic epidemiology, Case-Control Studies, Multiple comparisons problem, genetics [Polymorphism, Single Nucleotide], genetics [alpha-Synuclein], alpha-Synuclein, Female, Neurology (clinical), tau Proteins/*genetics, Case-Control Studie, Human
Abstract

Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods: Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach. Results: Fifteen GEO-PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1-haplotype-defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 30 end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale. Interpretation: This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011; 69: 778-792

Published
2011

34. Plasmonics Meets Biology through Optics

Author

De Sio, Luciano, primary, Caracciolo, Giulio, additional, Annesi, Ferdinanda, additional, Placido, Tiziana, additional, Pozzi, Daniela, additional, Comparelli, Roberto, additional, Pane, Alfredo, additional, Curri, Maria, additional, Agostiano, Angela, additional, and Bartolino, Roberto, additional

Published
2015
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35. Templating gold nanorods with liquid crystalline DNA

Author

De Sio, Luciano, primary, Annesi, Ferdinanda, additional, Placido, Tiziana, additional, Comparelli, Roberto, additional, Bruno, Vincenzo, additional, Pane, Alfredo, additional, Palermo, Giovanna, additional, Lucia Curri, Maria, additional, Umeton, Cesare, additional, and Bartolino, Roberto, additional

Published
2015
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39. Large-scale replication and heterogeneity in Parkinson disease genetic loci

Author

Sharma, Manu, primary, Ioannidis, John P.A., additional, Aasly, Jan O., additional, Annesi, Grazia, additional, Brice, Alexis, additional, Van Broeckhoven, Christine, additional, Bertram, Lars, additional, Bozi, Maria, additional, Crosiers, David, additional, Clarke, Carl, additional, Facheris, Maurizio, additional, Farrer, Matthew, additional, Garraux, Gaetan, additional, Gispert, Suzana, additional, Auburger, Georg, additional, Vilariño-Güell, Carles, additional, Hadjigeorgiou, Georgios M., additional, Hicks, Andrew A., additional, Hattori, Nobutaka, additional, Jeon, Beom, additional, Lesage, Suzanne, additional, Lill, Christina M., additional, Lin, Juei-Jueng, additional, Lynch, Timothy, additional, Lichtner, Peter, additional, Lang, Anthony E., additional, Mok, Vincent, additional, Jasinska-Myga, Barbara, additional, Mellick, George D., additional, Morrison, Karen E., additional, Opala, Grzegorz, additional, Pramstaller, Peter P., additional, Pichler, Irene, additional, Park, Sung Sup, additional, Quattrone, Aldo, additional, Rogaeva, Ekaterina, additional, Ross, Owen A., additional, Stefanis, Leonidas, additional, Stockton, Joanne D., additional, Satake, Wataru, additional, Silburn, Peter A., additional, Theuns, Jessie, additional, Tan, Eng-King, additional, Toda, Tatsushi, additional, Tomiyama, Hiroyuki, additional, Uitti, Ryan J., additional, Wirdefeldt, Karin, additional, Wszolek, Zbigniew, additional, Xiromerisiou, Georgia, additional, Yueh, Kuo-Chu, additional, Zhao, Yi, additional, Gasser, Thomas, additional, Maraganore, Demetrius, additional, Krüger, Rejko, additional, Boyle, R.S, additional, Sellbach, A, additional, O'Sullivan, J.D., additional, Sutherland, G.T., additional, Siebert, G.A, additional, Dissanayaka, N.N.W, additional, Pickut, Barbara, additional, Engelborghs, Sebastiaan, additional, Meeus, Bram, additional, De Deyn, Peter P., additional, Cras, Patrick, additional, Lang, Anthony E, additional, Agid, Y, additional, Anheim, M, additional, Bonnet, A-M, additional, Borg, M, additional, Brice, A, additional, Broussolle, E, additional, Corvol, JC, additional, Damier, P, additional, Destée, A, additional, Dürr, A, additional, Durif, F, additional, Lesage, S, additional, Lohmann, E, additional, Pollak, P, additional, Rascol, O, additional, Tison, F, additional, Tranchant, C, additional, Viallet, F, additional, Vidailhet, M, additional, Tzourio, Christophe, additional, Amouyel, Philippe, additional, Loriot, Marie-Anne, additional, Mutez, Eugénie, additional, Duflot, Aurélie, additional, Legendre, Jean-Philippe, additional, Waucquier, Nawal, additional, Riess, Olaf, additional, Berg, Daniela, additional, Schulte, Claudia, additional, Klein, Christine, additional, Djarmati, Ana, additional, Hagenah, Johann, additional, Lohmann, Katja, additional, Hilker, Rüdiger, additional, van de Loo, Simone, additional, Dardiotis, Efthimios, additional, Tsimourtou, Vaia, additional, Ralli, Styliani, additional, Kountra, Persa, additional, Patramani, Gianna, additional, Vogiatzi, Cristina, additional, Funayama, Manabu, additional, Yoshino, Hiroyo, additional, Li, Yuanzhe, additional, Imamichi, Yoko, additional, Lynch, Tim, additional, Gibson, J. Mark, additional, Valente, Enza Maria, additional, Ferraris, Alessandro, additional, Dallapiccola, Bruno, additional, Ialongo, Tamara, additional, Brighina, Laura, additional, Corradi, Barbara, additional, Piolti, Roberto, additional, Tarantino, Patrizia, additional, Annesi, Ferdinanda, additional, Jeon, Beom S., additional, Park, Sung-Sup, additional, Aasly, J, additional, Klodowska-Duda, Gabriela, additional, Boczarska-Jedynak, Magdalena, additional, Tan, Eng King, additional, Belin, Andrea Carmine, additional, Olson, Lars, additional, Galter, Dagmar, additional, Westerlund, Marie, additional, Sydow, Olof, additional, Nilsson, Christer, additional, Puschmann, Andreas, additional, Lin, JJ, additional, Maraganore, Demetrius M., additional, Ahlskog, J, Eric, additional, de Andrade, Mariza, additional, Lesnick, Timothy G., additional, Rocca, Walter A., additional, Checkoway, Harvey, additional, Ross, Owen A, additional, and Wszolek, Zbigniew K., additional

Published
2012
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40. Lack of association between G‐protein coupled receptor kinase 5 gene and Parkinson's disease

Author

Tarantino, Patrizia, primary, De Marco, Elvira Valeria, additional, Annesi, Grazia, additional, Rocca, Francesca Emanuela, additional, Annesi, Ferdinanda, additional, Civitelli, Donatella, additional, Provenzano, Giovanni, additional, Scornaienchi, Vittorio, additional, Greco, Valentina, additional, Colica, Carmela, additional, Nicoletti, Giuseppe, additional, and Quattrone, Aldo, additional

Published
2010
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41. Author’s reply to the comment of Sironi et al. on “Compound heterozygosity in DJ-1 gene non-coding portion related to Parkinsonism”

Author

Tarantino, Patrizia, primary, Civitelli, Donatella, additional, Annesi, Ferdinanda, additional, De Marco, Elvira V., additional, Rocca, Francesca E., additional, Pugliese, Pierfrancesco, additional, Nicoletti, Giuseppe, additional, Carrideo, Sara, additional, Provenzano, Giovanni, additional, Annesi, Grazia, additional, and Quattrone, Aldo, additional

Published
2010
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43. Myocardial123metaiodobenzylguanidine uptake in genetic Parkinson's disease

Author

Quattrone, Aldo, primary, Bagnato, Antonio, additional, Annesi, Grazia, additional, Novellino, Fabiana, additional, Morgante, Letterio, additional, Savettieri, Giovanni, additional, Zappia, Mario, additional, Tarantino, Patrizia, additional, Candiano, Innocenza Claudia Cirò, additional, Annesi, Ferdinanda, additional, Civitelli, Donatella, additional, Rocca, Francesca Emanuela, additional, D'Amelio, Marco, additional, Nicoletti, Giuseppe, additional, Morelli, Maurizio, additional, Petrone, Alfredo, additional, Loizzo, Piercostanzo, additional, and Condino, Francesca, additional

Published
2008
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44. Applications of nanomaterials in modern medicine.

Author

Sio, Luciano, Caracciolo, Giulio, Placido, Tiziana, Pozzi, Daniela, Comparelli, Roberto, Annesi, Ferdinanda, Curri, Maria, Agostiano, Angela, and Bartolino, Roberto

Abstract

Nanomaterials represent a class of materials based on nanoscale structures. Nanomaterials are currently used in a wide variety of applications, including, optoelectronics, energy conversion, biology health care and medicine. Among different types of nanomaterials, gold nanoparticles have received considerable attention in disease diagnosis and therapy due to their optical and chemical properties (Liz-Marzan in Mater Today 7:26-31, ). This paper reports the main optical and photo-thermal properties of gold nanoparticles. Particularly, we show that gold nanorods embedded in cholesteric liquid crystals demonstrate to control the 'selective reflection' of a light beam. Investigation of the optical properties of the obtained material reveals an original and efficient tool to detect temperature variations at the nanoscale useful for photo-thermal based therapies applications. Finally, the concept of 'nanoparticle-protein corona interaction can be exploited for application ranging from regenerative medicine to theranostics. [ABSTRACT FROM AUTHOR]

Published
2015
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45. Identification of an Na v 1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures

Author

Mantegazza, Massimo, primary, Gambardella, Antonio, additional, Rusconi, Raffaella, additional, Schiavon, Emanuele, additional, Annesi, Ferdinanda, additional, Cassulini, Rita Restano, additional, Labate, Angelo, additional, Carrideo, Sara, additional, Chifari, Rosanna, additional, Canevini, Maria Paola, additional, Canger, Raffaele, additional, Franceschetti, Silvana, additional, Annesi, Grazia, additional, Wanke, Enzo, additional, and Quattrone, Aldo, additional

Published
2005
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46. DJ‐1 mutations and parkinsonism‐dementia‐amyotrophic lateral sclerosis complex

Author

Annesi, Grazia, primary, Savettieri, Giovanni, additional, Pugliese, Pierfrancesco, additional, D'Amelio, Marco, additional, Tarantino, Patrizia, additional, Ragonese, Paolo, additional, La Bella, Vincenzo, additional, Piccoli, Tommaso, additional, Civitelli, Donatella, additional, Annesi, Ferdinanda, additional, Fierro, Brigida, additional, Piccoli, Federico, additional, Arabia, Gennarina, additional, Caracciolo, Manuela, additional, Cirò Candiano, Innocenza Claudia, additional, and Quattrone, Aldo, additional

Published
2005
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47. Chronic bilateral subthalamic deep brain stimulation in a patient with homozygous deletion in the Parkin gene

Author

Capecci, Marianna, primary, Passamonti, Luca, additional, Annesi, Ferdinanda, additional, Annesi, Grazia, additional, Bellesi, Michele, additional, Candiano, Innocenza Claudia Cirò, additional, Ricciuti, Riccardo, additional, Iacoangeli, Maurizio, additional, Scerrati, Massimo, additional, Zappia, Mario, additional, Tarantino, Patrizia, additional, De Marco, Elvira Valeria, additional, Civitelli, Donatella, additional, Carrideo, Sara, additional, Provinciali, Leandro, additional, Ceravolo, Maria Gabriella, additional, and Quattrone, Aldo, additional

Published
2004
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48. FRAXE intermediate alleles are associated with Parkinson’s disease

Author

Annesi, Grazia, primary, Nicoletti, Giuseppe, additional, Tarantino, Patrizia, additional, Cutuli, Nunzio, additional, Annesi, Ferdinanda, additional, Marco, Elvira Valeria De, additional, Zappia, Mario, additional, Morgante, Letterio, additional, Arabia, Gennarina, additional, Pugliese, Pierfrancesco, additional, Condino, Francesca, additional, Carrideo, Sara, additional, Civitelli, Donatella, additional, Caracciolo, Manuela, additional, Romeo, Nelide, additional, Spadafora, Patrizia, additional, Candiano, Innocenza Cirò, additional, and Quattrone, Aldo, additional

Published
2004
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49. No evidence of association between the alpha-2 macroglobulin gene and Parkinson's disease in a case–control sample

Author

Nicoletti, Giuseppe, primary, Annesi, Grazia, additional, Tomaino, Carmine, additional, Spadafora, Patrizia, additional, Pasqua, Angela Aurora, additional, Annesi, Ferdinanda, additional, Serra, Paolo, additional, Caracciolo, Manuela, additional, Messina, Demetrio, additional, Zappia, Mario, additional, and Quattrone, Aldo, additional

Published
2002
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50. Vitamin E deficiency due to chylomicron retention disease in Marinesco-Sj�gren syndrome

Author

Aguglia, Umberto, primary, Annesi, Grazia, additional, Pasquinelli, Gianandrea, additional, Spadafora, Patrizia, additional, Gambardella, Antonio, additional, Annesi, Ferdinanda, additional, Pasqua, Angela Aurora, additional, Cavalcanti, Francesca, additional, Crescibene, Lucia, additional, Bagal�, Angelo, additional, Bono, Francesco, additional, Oliveri, Rosario L., additional, Valentino, Paola, additional, Zappia, Mario, additional, and Quattrone, Aldo, additional

Published
2000
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