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1. Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

Author

Martijn H. den Brok, Christian Büll, Melissa Wassink, Annemarie M. de Graaf, Jori A. Wagenaars, Marthe Minderman, Mayank Thakur, Sebastian Amigorena, Eric O. Rijke, Carla C. Schrier, and Gosse J. Adema

Subjects
Science
Abstract

Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells.

Published
2016
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