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392 results on '"Annecke, Thorsten"'

1. Intraoperative haemodynamic monitoring and management of adults having non-cardiac surgery: Guidelines of the German Society of Anaesthesiology and Intensive Care Medicine in collaboration with the German Association of the Scientific Medical Societies

Author

Saugel, Bernd, Annecke, Thorsten, Bein, Berthold, Flick, Moritz, Goepfert, Matthias, Gruenewald, Matthias, Habicher, Marit, Jungwirth, Bettina, Koch, Tilo, Kouz, Karim, Meidert, Agnes S, Pestel, Gunther, Renner, Jochen, Sakka, Samir G, Sander, Michael, Treskatsch, Sascha, Zitzmann, Amelie, and Reuter, Daniel A

Published
2024
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3. Protein Interaction Assessing Mitochondrial Biogenesis as a Next Generation Biomarker in Sepsis: A Prospective Cohort Study

Author

Adamzik, Michael, Adamzik, Stephanie, Bazzi, Maha, Bergmann, Lars, von Busch, Alexander, Haberl, Helge, Koos, Björn, Nowak, Hartmuth, Rahmel, Barbara, Rahmel, Tim, Rump, Katharina, Unterberg, Matthias, Willemsen, Katrin, Wolf, Alexander, Zuelch, Birgit, Anft, Moritz, Babel, Nina, Annecke, Thorsten, Defosse, Jerome M., Limper, Ulrich, Wappler, Frank, Bode, Christian, Ehrentraut, Stefan F., Putensen, Christian, Schewe, Jens-Christian, Bracht, Thilo, Sitek, Barbara, Eisennacher, Martin, Kleefisch, Daniel, Marcus, Katrin, Ellger, Björn, Oswald, Daniel, Ertmer, Christian, Zarbock, Alexander, Frey, Ulrich H., Fuchs, Katrin, Henzler, Dietrich, Köhler, Thomas, Schwier, Elke, Thon, Patrick, Trübner, Ellen, Zimmer, Frieda, Palmowski, Lars, Witowski, Andrea, Marko, Britta, and Ziehe, Dominik

Published
2024
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8. Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial

Author

Hagel, Stefan, Bach, Friedhelm, Brenner, Thorsten, Bracht, Hendrik, Brinkmann, Alexander, Annecke, Thorsten, and Hohn, Andreas

Subjects
Fresenius Medical Care AG & Company KGaA, Biotest AG, Health care industry -- Health aspects, Infection -- Care and treatment, Clinical trials -- Health aspects, Antibiotics -- Evaluation, Septic shock -- Care and treatment, Health care industry
Abstract

Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. Methods Randomized, multicenter, controlled trial from January 2017 to December 2019. Adult patients (n = 254) with sepsis or septic shock were randomly assigned 1:1 to receive continuous infusion of piperacillin/tazobactam with dosing guided by daily TDM of piperacillin or continuous infusion with a fixed dose (13.5 g/24 h if eGFR [greater than or equal to] 20 mL/min). Target plasma concentration was four times the minimal inhibitory concentration (range ± 20%) of the underlying pathogen, respectively, of Pseudomonas aeruginosa in empiric situation. Primary outcome was the mean of daily total Sequential Organ Failure Assessment (SOFA) score up to day 10. Results Among 249 evaluable patients (66.3 ± 13.7 years; female, 30.9%), there was no significant difference in mean SOFA score between patients with TDM (7.9 points; 95% CI 7.1-8.7) and without TDM (8.2 points; 95% CI 7.5-9.0) (p = 0.39). Patients with TDM-guided therapy showed a lower 28-day mortality (21.6% vs. 25.8%, RR 0.8, 95% CI 0.5-1.3, p = 0.44) and a higher rate of clinical (OR 1.9; 95% CI 0.5-6.2, p = 0.30) and microbiological cure (OR 2.4; 95% CI 0.7-7.4, p = 0.12), but these differences did not reach statistical significance. Attainment of target concentration was more common in patients with TDM (37.3% vs. 14.6%, OR 4.5, CI 95%, 2.9-6.9, p < 0.001). Conclusion TDM-guided therapy showed no beneficial effect in patients with sepsis and continuous infusion of piperacillin/tazobactam with regard to the mean SOFA score. Larger studies with strategies to ensure optimization of antimicrobial exposure are needed to definitively answer the question., Author(s): Stefan Hagel [sup.1] [sup.2], Friedhelm Bach [sup.3], Thorsten Brenner [sup.4] [sup.5], Hendrik Bracht [sup.6], Alexander Brinkmann [sup.7], Thorsten Annecke [sup.8] [sup.9], Andreas Hohn [sup.8] [sup.10], Markus Weigand [sup.5], Guido [...]

Published
2022
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10. Opioide

Author

Larsen, Reinhard, primary, Annecke, Thorsten, additional, and Fink, Tobnias, additional

Published
2022
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21. Blutgase

Author

Larsen, Reinhard, primary, Annecke, Thorsten, additional, and Fink, Tobnias, additional

Published
2022
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24. Adressen

Author

Larsen, Reinhard, primary, Annecke, Thorsten, additional, and Fink, Tobias, additional

Published
2022
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25. Herzfunktion

Author

Larsen, Reinhard, primary, Annecke, Thorsten, additional, and Fink, Tobnias, additional

Published
2022
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49. Intraoperative klinische Anwendung von hämodynamischem Monitoring bei nicht-kardiochirur-gischen Patient:innen.

Author

Saugel, Bernd, Annecke, Thorsten, Bein, Berthold, Flick, Moritz, Goepfert, Matthias, Gruenewald, Matthias, Habicher, Marit, Jungwirth, Bettina, Koch, Tilo, Kouz, Karim, Meidert, Agnes S., Pestel, Gunther, Renner, Jochen, Sakka, Samir, Sander, Michael, Treskatsch, Sascha, Zitzmann, Amelie, and Reuter, Daniel A.

Subjects
HEMODYNAMICS, INTRAOPERATIVE monitoring, CENTRAL venous pressure, ELECTIVE surgery, PATIENT monitoring, ECHOCARDIOGRAPHY
Published
2024
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50. Inhalationsanästhetika

Author

Loscar, Monika, Annecke, Thorsten, Conzen, Peter, Werner, Christian, Section editor, Rossaint, Rolf, editor, Werner, Christian, editor, and Zwißler, Bernhard, editor

Published
2019
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