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1. Follow-up investigation into Cryptosporidium prevalence and transmission in Western European dairy farms

Author

Sumaiya Hoque, Pedro Pinto, Cláudia A. Ribeiro, Evi Canniere, Yvonne Daandels, Martine Dellevoet, Anne Bourgeois, Ourida Hammouma, Paul Hunter, Eleni Gentekaki, Martin Kváč, Jérôme Follet, Anastasios D. Tsaousis, University of Kent [Canterbury], Faculdade de Engenharia da Universidade do Porto (FEUP), Universidade do Porto = University of Porto, University of Algarve [Portugal], Inagro, Biological Data Analysis ['s-Hertogenbosch, The Netherlands], PamGene International B.V. ['s-Hertogenbosch, The Netherlands], Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), JUNIA (JUNIA), Université catholique de Lille (UCL), University of Lille, Université libre de Bruxelles (ULB), University of East Anglia [Norwich] (UEA), Faculty of Computer Science, Dalhousie University [Halifax], Mae Fah Luang University [Thaïlande] (MFU), Institute of Parasitology [České Budějovice] (BIOLOGY CENTRE CAS), Biology Centre of the Czech Academy of Sciences (BIOLOGY CENTRE CAS), Czech Academy of Sciences [Prague] (CAS)-Czech Academy of Sciences [Prague] (CAS), University of South Bohemia, Faculty of Agriculture, Studentska 13, 370 05 Ceske Budejovice, Bio-Micro-Electro-Mechanical Systems - IEMN (BIOMEMS - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and no information

Subjects
[PHYS]Physics [physics], [SPI]Engineering Sciences [physics], General Veterinary, Belgium, Epidemiology, Dairy cows, Prevalence, Cryptosporidium, Parasitology, The Netherlands, General Medicine, France, Diarrhoea
Abstract

International audience; AbstractCryptosporidium parvum is an enteric parasite and a major contributor to acute enteritis in calves worldwide, causing an important economic burden for farmers. This parasite poses a major public health threat through transmission between livestock and humans. Our previous pilot study in Western Europe revealed a high prevalence of Cryptosporidium in calves of dairy farms. In the sequel study herein, 936 faecal samples were collected from the same 51 dairy farms across Belgium, France, and the Netherlands. Following DNA extraction, Cryptosporidium screening was carried out using nested-PCR amplification targeting the SSU rRNA gene. All positive samples were sequenced, and phylogenetic analyses were used to identify the Cryptosporidium spp. present. The 60 kDa glycoprotein (gp60) gene was also sequenced to determine the C. parvum subtypes present. Prevalence of Cryptosporidium ranged from 23.3% to 25%, across the three countries surveyed. The parasite was found in most of the farms sampled, with 90.2% testing positive. Cryptosporidium parvum, C. bovis, C. ryanae and C. andersoni were all identified, with the former being the most predominant, representing 71.4% of all infections. Cryptosporidium parvum was associated with pre-weaned calves, while other species were associated with older animals. Subtyping of gp60 gene revealed nine subtypes, eight of which have previously been reported to cause clinical disease in humans. Similarly to the first study, vertical transmission was not a major contributor to Cryptosporidium spread. Our study highlights the need for further investigation into cryptosporidiosis transmission, and future studies will require a One Health approach to reduce the impact of this disease.

Published
2023

2. Supplementary Figure 2 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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3. Data from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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4. Supplementary Figure 3 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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5. Supplementary Figure 1 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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6. Supplementary Figure 7 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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7. Supplementary Figure 6 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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8. Supplementary Figure Legends from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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9. Supplementary Figure 5 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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10. Supplementary Figure 4 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, primary, Basbous, Sara, primary, Jacomet, Florence, primary, Féraud, Olivier, primary, Anne Bourgeois, Elvire, primary, Bonnet, Marie-Laure, primary, Giraud, Christine, primary, Roy, Lydia, primary, Barra, Anne, primary, Chomel, Jean-Claude, primary, Turhan, Ali, primary, Guilhot, François, primary, Girard, Jean-Philippe, primary, Gombert, Jean-Marc, primary, and Herbelin, André, primary

Published
2023
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12. Supplementary Figure 7 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

André Herbelin, Jean-Marc Gombert, Jean-Philippe Girard, François Guilhot, Ali Turhan, Jean-Claude Chomel, Anne Barra, Lydia Roy, Christine Giraud, Marie-Laure Bonnet, Elvire Anne Bourgeois, Olivier Féraud, Florence Jacomet, Sara Basbous, Stéphane Flamant, and Anaïs Levescot

Abstract

PDF file - 208KB, Xenotransplant experiments in immunodeficient NOG mice (A); Mouse model of CML-like induced syndrome (B-C).

Published
2023

13. Supplementary Figure 6 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

André Herbelin, Jean-Marc Gombert, Jean-Philippe Girard, François Guilhot, Ali Turhan, Jean-Claude Chomel, Anne Barra, Lydia Roy, Christine Giraud, Marie-Laure Bonnet, Elvire Anne Bourgeois, Olivier Féraud, Florence Jacomet, Sara Basbous, Stéphane Flamant, and Anaïs Levescot

Abstract

PDF file - 105KB, CML is associated with high circulating levels of soluble ST2: reversion after IM therapy.

Published
2023

14. Supplementary Figure 2 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

André Herbelin, Jean-Marc Gombert, Jean-Philippe Girard, François Guilhot, Ali Turhan, Jean-Claude Chomel, Anne Barra, Lydia Roy, Christine Giraud, Marie-Laure Bonnet, Elvire Anne Bourgeois, Olivier Féraud, Florence Jacomet, Sara Basbous, Stéphane Flamant, and Anaïs Levescot

Abstract

PDF file - 192KB, CML-CP CD34(+) cells proliferate in response to IL-33.

Published
2023

15. Supplementary Figure 4 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

André Herbelin, Jean-Marc Gombert, Jean-Philippe Girard, François Guilhot, Ali Turhan, Jean-Claude Chomel, Anne Barra, Lydia Roy, Christine Giraud, Marie-Laure Bonnet, Elvire Anne Bourgeois, Olivier Féraud, Florence Jacomet, Sara Basbous, Stéphane Flamant, and Anaïs Levescot

Abstract

PDF file - 145KB, IL-33 is as efficient as SCF in inducing proliferation of CML-CP CD34(+) cells.

Published
2023

16. Supplementary Figure 1 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

André Herbelin, Jean-Marc Gombert, Jean-Philippe Girard, François Guilhot, Ali Turhan, Jean-Claude Chomel, Anne Barra, Lydia Roy, Christine Giraud, Marie-Laure Bonnet, Elvire Anne Bourgeois, Olivier Féraud, Florence Jacomet, Sara Basbous, Stéphane Flamant, and Anaïs Levescot

Abstract

PDF file - 200KB, The kinase activity of BCR-ABL induces upregulation of ST2 in UT7 cells.

Published
2023

17. Supplementary Figure 5 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

André Herbelin, Jean-Marc Gombert, Jean-Philippe Girard, François Guilhot, Ali Turhan, Jean-Claude Chomel, Anne Barra, Lydia Roy, Christine Giraud, Marie-Laure Bonnet, Elvire Anne Bourgeois, Olivier Féraud, Florence Jacomet, Sara Basbous, Stéphane Flamant, and Anaïs Levescot

Abstract

PDF file - 154KB, CML-CP CD34(+) cells proliferate in response to IL-33 independently from GM-CSF.

Published
2023

18. Supplementary Figure 3 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

André Herbelin, Jean-Marc Gombert, Jean-Philippe Girard, François Guilhot, Ali Turhan, Jean-Claude Chomel, Anne Barra, Lydia Roy, Christine Giraud, Marie-Laure Bonnet, Elvire Anne Bourgeois, Olivier Féraud, Florence Jacomet, Sara Basbous, Stéphane Flamant, and Anaïs Levescot

Abstract

PDF file - 118KB, IL-33 does not modulate apoptosis of CD34(+) cells from CML-CP patients.

Published
2023

19. Data from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

André Herbelin, Jean-Marc Gombert, Jean-Philippe Girard, François Guilhot, Ali Turhan, Jean-Claude Chomel, Anne Barra, Lydia Roy, Christine Giraud, Marie-Laure Bonnet, Elvire Anne Bourgeois, Olivier Féraud, Florence Jacomet, Sara Basbous, Stéphane Flamant, and Anaïs Levescot

Abstract

Although it is generally acknowledged that cytokines regulate normal hematopoiesis in an autocrine/paracrine fashion, their possible role in chronic myelogenous leukemia (CML) and resistance to imatinib mesylate treatment remain poorly investigated. Here, we report that CD34(+) progenitors from patients with CML at diagnosis are selectively targeted by the cytokine/alarmin interleukin (IL)-33. Indeed, CML CD34(+) progenitors upregulate their cell surface expression of the IL-33–specific receptor chain ST2, proliferate and produce cytokines in response to IL-33, conversely to CD34(+) cells from healthy individuals. Moreover, ST2 overexpression is normalized following imatinib mesylate therapy, whereas IL-33 counteracts in vitro imatinib mesylate-induced growth arrest in CML CD34(+) progenitors via reactivation of the STAT5 pathway, thus supporting the notion that IL-33 may impede the antiproliferative effects of imatinib mesylate on CD34(+) progenitors in CML. Clinically, the levels of circulating soluble ST2, commonly considered a functional signature of IL-33 signaling in vivo, correlate with disease burden. Indeed, these elevated peripheral concentrations associated with a high Sokal score predictive of therapeutic outcome are normalized in patients in molecular remission. Finally, we evidenced a facilitating effect of IL-33 on in vivo maintenance of CD34(+) progenitors from patients with CML by using xenotransplant experiments in immunodeficient NOG mice, and we showed that engraftment of mouse BCR-ABL–transfected bone marrow progenitors was less efficient in IL-33–deficient mice compared with wild-type recipients. Taken together, our results provide evidence that IL-33/ST2 signaling may represent a novel cytokine-mediated mechanism contributing to CML progenitor growth and support a role for this pathway in CML maintenance and imatinib mesylate resistance. Cancer Res; 74(10); 2669–76. ©2014 AACR.

Published
2023

21. Valeurs familiales, histoire maritale et familiale

Author

Jacques Légaré and Anne Bourgeois

Subjects
Health (social science), Geriatrics and Gerontology, Gerontology
Abstract

Le lien entre valeurs et comportements demographiques est ici presente dans le contexte de la grand-parentalite en France. De par leur statut, les grands-parents font, sans contredit, figure de « seniors » experimentes dans le domaine de la famille, pour avoir vecu a la fois des transitions conjugales et familiales. Leurs valeurs familiales pourraient-elles etre plus affirmees du fait de ce statut particulier ? L’etude suivante propose d’examiner ces valeurs aupres d’individus nes entre 1926 et 1965, au regard de leur histoire conjugale et familiale, en distinguant les grands-peres des grand-meres appartenant a differentes generations, puis en comparant les valeurs familiales des grands-parents par rapport aux parents sans petit-enfant et aux repondants sans enfant ni petit-enfant, nes au cours des memes generations. En premier lieu, toutes les generations de grands-parents ne se ressemblent pas du point de vue des valeurs percues, surtout les plus jeunes, davantage marquees par la liberalisation des mœurs des la fin des annees 1960. Les jeunes grand-meres se demarquent quelque peu des jeunes grands-peres quant aux solidarites familiales et a l’importance d’avoir des enfants. Par ailleurs, les grands-parents presentent des valeurs familiales un peu plus marquees que les repondants qui n’ont pas de petits-enfants, surtout s’ils sont nes entre 1946 et 1966. Les grands-parents reconnaissent ainsi davantage l’importance d’avoir des enfants que les parents sans petit-enfant et se montrent plus favorables a aider leur enfants adultes.

Published
2009

22. Les Propriétés Psychométriques De La Version Française Du Modified Mini-Mental State (3Ms) Avec Des Patients âgés Suivis En Psychiatrie Gŕriatrique

Author

Marie Quintal, Philippe Cappeliez, Michel Finlay, Serge Gagne, Anne Bourgeois, ET Andree Robillard, and Mariette Blouin

Subjects
Psychiatry and Mental health, medicine.medical_specialty, Validation test, Mental state, medicine, language, French, Dementia diagnosis, Senile dementia, Psychiatry, Psychology, Geriatric psychiatry, language.human_language
Abstract

Objectif: Cette recherche étudie les propriétés psychométriques de la version française du Modified Mini-Mental State (SMS), un instrument de dépistage de la démence, avec un échantillon de patients suivis en psychiatrie gériatrique. Méthode: Les sujets (N = 94; 63 ans à 92 ans) sont des patients externes référés à un service hospitalier de psychiatrie gériatrique. Outre le 3MS, une batterie de tests portant sur le fonctionnement cognitif et la Symptomatologie dépressive a été administrée. Résultats: Le coefficient de fidélité test-retest s'élève à 0,87 pour un sous-échantillon de 35 sujets. Une analyse factorielle de type exploratoire révèle 4 facteurs qui rendent compte de 63,2 % de la variance. Des scores-seuils de 79 à 80 (avec scolarisation ⩾ 8 ans) et de 71 à 72 (avec scolarisation ⩽ 7 ans) offrent la meilleure combinaison sensibilité/spécificité, soit respectivement 0,80 et 0,96. Conclusions: Cette étude soutient les qualités psychométriques de la version française du 3MS pour l'utilisation avec des patients suivis en psychiatrie gériatrique, en proposant des seuils qui tiennent compte du niveau d'éducation. Elle souligne l'influence des variables sociodémographiques sur les performances au test.

Published
1996

23. Evaluating a nurse practitioner service

Author

Anne Bourgeois, Mary K. Alexander, Maureen McMullen, and Lillian R. Goodman

Subjects
District nurse, Adult, Male, medicine.medical_specialty, Nurse practitioners, Attitude of Health Personnel, MEDLINE, Emergency Nursing, Critical Care Nursing, Patient satisfaction, Nursing, Acute care, Health care, Outcome Assessment, Health Care, Medical Staff, Hospital, Medicine, Humans, Nurse Practitioners, Aged, Service (business), Aged, 80 and over, Patient Care Team, Practice Patterns, Nurses', business.industry, Middle Aged, Oncology nursing, Massachusetts, Patient Satisfaction, Female, business
Abstract

Increasingly, nurse practitioners are filling resident and house staff shortages by moving into acute care settings. This article compares a nurse practitioner/attending collaborative service with a traditional physician-based service in terms of patient outcomes and patient, physician, and staff satisfaction.

Published
2011

25. BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

Author

Levescot, Anaïs, primary, Flamant, Stéphane, additional, Basbous, Sara, additional, Jacomet, Florence, additional, Féraud, Olivier, additional, Anne Bourgeois, Elvire, additional, Bonnet, Marie-Laure, additional, Giraud, Christine, additional, Roy, Lydia, additional, Barra, Anne, additional, Chomel, Jean-Claude, additional, Turhan, Ali, additional, Guilhot, François, additional, Girard, Jean-Philippe, additional, Gombert, Jean-Marc, additional, and Herbelin, André, additional

Published
2014
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26. An acute/critical care nurse practitioner program

Author

Lillian R. Goodman, Mary K. Alexander, Anne Bourgeois, and Matthew Higgs

Subjects
District nurse, Surgical nursing, Quality management, Critical Care, Leadership and Management, InformationSystems_GENERAL, Oncology nursing, Education, Nursing, Continuing, Nursing, Job Description, Critical care nursing, Acute Disease, ComputingMilieux_COMPUTERSANDEDUCATION, Humans, Nurse Practitioners, Nurse education, Curriculum, Psychology, Unlicensed assistive personnel
Abstract

To meet the demands for quality care, nursing education and nursing practice must collaborate and integrate services to educate Advanced Practice Nurses (APNs). One teaching hospital's successful APN curriculum is described. Topics addressed include structural reengineering, continuous quality improvement (CQI) and curriculum redesign.

Published
1996

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