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1. Early neurotransmitters changes in prodromal frontotemporal dementia: A GENFI study

Author: Enrico Premi, Marta Pengo, Irene Mattioli, Valentina Cantoni, Juergen Dukart, Roberto Gasparotti, Emanuele Buratti, Alessandro Padovani, Martina Bocchetta, Emily G. Todd, Arabella Bouzigues, David M. Cash, Rhian S. Convery, Lucy L. Russell, Phoebe Foster, David L. Thomas, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Jr, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Kamen A. Tsvetanov, Rik Vandenberghe, Elizabeth Finger, Pietro Tiraboschi, Alexandre de Mendonça, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Johannes Levin, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Jonathan D. Rohrer, Barbara Borroni, Aitana Sogorb Esteve, Carolin Heller, Caroline V. Greaves, Henrik Zetterberg, Imogen J. Swift, Kiran Samra, Rachelle Shafei, Carolyn Timberlake, Thomas Cope, Timothy Rittman, Andrea Arighi, Chiara Fenoglio, Elio Scarpini, Giorgio Fumagalli, Vittoria Borracci, Giacomina Rossi, Giorgio Giaccone, Giuseppe Di Fede, Paola Caroppo, Sara Prioni, Veronica Redaelli, David Tang-Wai, Ekaterina Rogaeva, Miguel Castelo-Branco, Morris Freedman, Ron Keren, Sandra Black, Sara Mitchell, Christen Shoesmith, Robart Bartha, Rosa Rademakers, Jackie Poos, Janne M. Papma, Lucia Giannini, Rick van Minkelen, Yolande Pijnenburg, Benedetta Nacmias, Camilla Ferrari, Cristina Polito, Gemma Lombardi, Valentina Bessi, Michele Veldsman, Christin Andersson, Hakan Thonberg, Linn Öijerstedt, Vesna Jelic, Paul Thompson, Tobias Langheinrich, Albert Lladó, Anna Antonell, Jaume Olives, Mircea Balasa, Nuria Bargalló, Sergi Borrego-Ecija, Ana Verdelho, Carolina Maruta, Catarina B. Ferreira, Gabriel Miltenberger, Frederico Simões do Couto, Alazne Gabilondo, Ana Gorostidi, Jorge Villanua, Marta Cañada, Mikel Tainta, Miren Zulaica, Myriam Barandiaran, Patricia Alves, Benjamin Bender, Carlo Wilke, Lisa Graf, Annick Vogels, Mathieu Vandenbulcke, Philip Van Damme, Rose Bruffaerts, Koen Poesen, Pedro Rosa-Neto, Serge Gauthier, Agnès Camuzat, Alexis Brice, Anne Bertrand, Aurélie Funkiewiez, Daisy Rinaldi, Dario Saracino, Olivier Colliot, Sabrina Sayah, Catharina Prix, Elisabeth Wlasich, Olivia Wagemann, Sandra Loosli, Sonja Schönecker, Tobias Hoegen, Jolina Lombardi, Sarah Anderl-Straub, Adeline Rollin, Gregory Kuchcinski, Maxime Bertoux, Thibaud Lebouvier, Vincent Deramecourt, Beatriz Santiago, Diana Duro, Maria João Leitão, Maria Rosario Almeida, Miguel Tábuas-Pereira, and Sónia Afonso
Subjects: Frontotemporal dementia, Frontotemporal lobar degeneration, Genes, Magnetic resonance imaging, Positron emission tomography, Neurotransmitters, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Background: Neurotransmitters deficits in Frontotemporal Dementia (FTD) are still poorly understood. Better knowledge of neurotransmitters impairment, especially in prodromal disease stages, might tailor symptomatic treatment approaches. Methods: In the present study, we applied JuSpace toolbox, which allowed for cross-modal correlation of Magnetic Resonance Imaging (MRI)-based measures with nuclear imaging derived estimates covering various neurotransmitter systems including dopaminergic, serotonergic, noradrenergic, GABAergic and glutamatergic neurotransmission.We included 392 mutation carriers (157 GRN, 164 C9orf72, 71 MAPT), together with 276 non-carrier cognitively healthy controls (HC). We tested if the spatial patterns of grey matter volume (GMV) alterations in mutation carriers (relative to HC) are correlated with specific neurotransmitter systems in prodromal (CDR® plus NACC FTLD = 0.5) and in symptomatic (CDR® plus NACC FTLD≥1) FTD. Results: In prodromal stages of C9orf72 disease, voxel-based brain changes were significantly associated with spatial distribution of dopamine and acetylcholine pathways; in prodromal MAPT disease with dopamine and serotonin pathways, while in prodromal GRN disease no significant findings were reported (p
Published: 2023
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2. AD Course Map charts Alzheimer’s disease progression

Author: Igor Koval, Alexandre Bône, Maxime Louis, Thomas Lartigue, Simona Bottani, Arnaud Marcoux, Jorge Samper-González, Ninon Burgos, Benjamin Charlier, Anne Bertrand, Stéphane Epelbaum, Olivier Colliot, Stéphanie Allassonnière, and Stanley Durrleman
Subjects: Medicine, Science
Abstract: Abstract Alzheimer’s disease (AD) is characterized by the progressive alterations seen in brain images which give rise to the onset of various sets of symptoms. The variability in the dynamics of changes in both brain images and cognitive impairments remains poorly understood. This paper introduces AD Course Map a spatiotemporal atlas of Alzheimer’s disease progression. It summarizes the variability in the progression of a series of neuropsychological assessments, the propagation of hypometabolism and cortical thinning across brain regions and the deformation of the shape of the hippocampus. The analysis of these variations highlights strong genetic determinants for the progression, like possible compensatory mechanisms at play during disease progression. AD Course Map also predicts the patient’s cognitive decline with a better accuracy than the 56 methods benchmarked in the open challenge TADPOLE. Finally, AD Course Map is used to simulate cohorts of virtual patients developing Alzheimer’s disease. AD Course Map offers therefore new tools for exploring the progression of AD and personalizing patients care.
Published: 2021
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3. Intermittent Hypoxia Rewires the Liver Transcriptome and Fires up Fatty Acids Usage for Mitochondrial Respiration

Author: Jonathan Gaucher, Guillaume Vial, Emilie Montellier, Maëlle Guellerin, Sophie Bouyon, Emeline Lemarie, Véronique Pelloux, Anne Bertrand, Karin Pernet-Gallay, Frederic Lamarche, Anne-Laure Borel, Claire Arnaud, Elise Belaidi, Karine Clément, Diane Godin Ribuot, Judith Aron-Wisnewsky, and Jean-Louis Pépin
Subjects: sleep apnea, intermittent hypoxia (IH), liver, transcriptome, mitochondria, Nuclear Respiratory Factor (NRF), Medicine (General), R5-920
Abstract: Sleep Apnea Syndrome (SAS) is one of the most common chronic diseases, affecting nearly one billion people worldwide. The repetitive occurrence of abnormal respiratory events generates cyclical desaturation-reoxygenation sequences known as intermittent hypoxia (IH). Among SAS metabolic sequelae, it has been established by experimental and clinical studies that SAS is an independent risk factor for the development and progression of non-alcoholic fatty liver disease (NAFLD). The principal goal of this study was to decrypt the molecular mechanisms at the onset of IH-mediated liver injury. To address this question, we used a unique mouse model of SAS exposed to IH, employed unbiased high-throughput transcriptomics and computed network analysis. This led us to examine hepatic mitochondrial ultrastructure and function using electron microscopy, high-resolution respirometry and flux analysis in isolated mitochondria. Transcriptomics and network analysis revealed that IH reprograms Nuclear Respiratory Factor- (NRF-) dependent gene expression and showed that mitochondria play a central role. We thus demonstrated that IH boosts the oxidative capacity from fatty acids of liver mitochondria. Lastly, the unbalance between oxidative stress and antioxidant defense is tied to an increase in hepatic ROS production and DNA damage during IH. We provide a comprehensive analysis of liver metabolism during IH and reveal the key role of the mitochondria at the origin of development of liver disease. These findings contribute to the understanding of the mechanisms underlying NAFLD development and progression during SAS and provide a rationale for novel therapeutic targets and biomarker discovery.
Published: 2022
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4. Nobody’s Perfect

Author: Anne Bertrand, Yurika Aonuki, Sihwei Chen, Henry Davis, Joash Gambarage, Laura Griffin, Marianne Huijsmans, Lisa Matthewson, Daniel Reisinger, Hotze Rullmann, Raiane Salles, Michael David Schwan, Neda Todorović, Bailey Trotter, and Jozina Vander Klok
Subjects: tense, aspect, perfect, perfective, experiential, resultative, Language and Literature
Abstract: This paper challenges the cross-linguistic validity of the tense–aspect category ‘perfect’ by investigating 15 languages from eight different families (Atayal, Brazilian Portuguese, Dutch, English, German, Gitksan, Japanese, Javanese, Korean, Mandarin, Niuean, Québec French, St’át’imcets, Swahili, and Tibetan). The methodology involves using the storyboard ‘Miss Smith’s Bad Day’ to test for the availability of experiential, resultative, recent-past, and continuous readings, as well as lifetime effects, result-state cancellability, narrative progression, and compatibility with definite time adverbials. Results show that the target forms in these languages can be classified into four groups: (a) past perfectives; (b) experientials; (c) resultatives; and (d) hybrids (which allow both experiential and resultative readings). It is argued that the main division is between past perfectives, which contain a ‘pronominal’ tense, on the one hand, and the other three groups on the other, which involve existential quantification, either over times (experiential) or over events (resultative). The methodological and typological implications of the findings are discussed. The main conclusion of the study is that there is no universal category of ‘the perfect’, and that instead, researchers should focus on identifying shared semantic components of tense–aspect categories across languages.
Published: 2022
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5. Differential early subcortical involvement in genetic FTD within the GENFI cohort

Author: Martina Bocchetta, Emily G. Todd, Georgia Peakman, David M. Cash, Rhian S. Convery, Lucy L. Russell, David L. Thomas, Juan Eugenio Iglesias, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Jonathan D. Rohrer, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Christin Andersson, Anna Antonell, Silvana Archetti, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló, Robart Bartha, Benjamin Bender, Alberto Benussi, Maxime Bertoux, Anne Bertrand, Valentina Bessi, Sandra Black, Sergi Borrego-Ecija, Jose Bras, Alexis Brice, Rose Bruffaerts, Agnès Camuzat, Marta Cañada, Valentina Cantoni, Paola Caroppo, Miguel Castelo-Branco, Olivier Colliot, Thomas Cope, Vincent Deramecourt, María de Arriba, Giuseppe Di Fede, Alina Díez, Diana Duro, Chiara Fenoglio, Camilla Ferrari, Catarina B. Ferreira, Nick Fox, Morris Freedman, Giorgio Fumagalli, Aurélie Funkiewiez, Alazne Gabilondo, Roberto Gasparotti, Serge Gauthier, Stefano Gazzina, Giorgio Giaccone, Ana Gorostidi, Caroline Greaves, Rita Guerreiro, Carolin Heller, Tobias Hoegen, Begoña Indakoetxea, Vesna Jelic, Hans-Otto Karnath, Ron Keren, Gregory Kuchcinski, Tobias Langheinrich, Thibaud Lebouvier, Maria João Leitão, Albert Lladó, Gemma Lombardi, Sandra Loosli, Carolina Maruta, Simon Mead, Lieke Meeter, Gabriel Miltenberger, Rick van Minkelen, Sara Mitchell, Katrina Moore, Benedetta Nacmias, Annabel Nelson, Jennifer Nicholas, Linn Öijerstedt, Jaume Olives, Sebastien Ourselin, Alessandro Padovani, Jessica Panman, Janne M. Papma, Yolande Pijnenburg, Cristina Polito, Enrico Premi, Sara Prioni, Catharina Prix, Rosa Rademakers, Veronica Redaelli, Daisy Rinaldi, Tim Rittman, Ekaterina Rogaeva, Adeline Rollin, Pedro Rosa-Neto, Giacomina Rossi, Martin Rossor, Beatriz Santiago, Dario Saracino, Sabrina Sayah, Elio Scarpini, Sonja Schönecker, Elisa Semler, Rachelle Shafei, Christen Shoesmith, Imogen Swift, Miguel Tábuas-Pereira, Mikel Tainta, Ricardo Taipa, David Tang-Wai, Paul Thompson, Hakan Thonberg, Carolyn Timberlake, Pietro Tiraboschi, Philip Van Damme, Mathieu Vandenbulcke, Michele Veldsman, Ana Verdelho, Jorge Villanua, Jason Warren, Carlo Wilke, Ione Woollacott, Elisabeth Wlasich, Henrik Zetterberg, and Miren Zulaica
Subjects: Genetic frontotemporal dementia, MRI imaging, Brain volumetry, Presymptomatic stage, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
Abstract: Background: Studies have previously shown evidence for presymptomatic cortical atrophy in genetic FTD. Whilst initial investigations have also identified early deep grey matter volume loss, little is known about the extent of subcortical involvement, particularly within subregions, and how this differs between genetic groups. Methods: 480 mutation carriers from the Genetic FTD Initiative (GENFI) were included (198 GRN, 202 C9orf72, 80 MAPT), together with 298 non-carrier cognitively normal controls. Cortical and subcortical volumes of interest were generated using automated parcellation methods on volumetric 3 T T1-weighted MRI scans. Mutation carriers were divided into three disease stages based on their global CDR® plus NACC FTLD score: asymptomatic (0), possibly or mildly symptomatic (0.5) and fully symptomatic (1 or more). Results: In all three groups, subcortical involvement was seen at the CDR 0.5 stage prior to phenoconversion, whereas in the C9orf72 and MAPT mutation carriers there was also involvement at the CDR 0 stage. In the C9orf72 expansion carriers the earliest volume changes were in thalamic subnuclei (particularly pulvinar and lateral geniculate, 9–10%) cerebellum (lobules VIIa-Crus II and VIIIb, 2–3%), hippocampus (particularly presubiculum and CA1, 2–3%), amygdala (all subregions, 2–6%) and hypothalamus (superior tuberal region, 1%). In MAPT mutation carriers changes were seen at CDR 0 in the hippocampus (subiculum, presubiculum and tail, 3–4%) and amygdala (accessory basal and superficial nuclei, 2–4%). GRN mutation carriers showed subcortical differences at CDR 0.5 in the presubiculum of the hippocampus (8%). Conclusions: C9orf72 expansion carriers show the earliest and most widespread changes including the thalamus, basal ganglia and medial temporal lobe. By investigating individual subregions, changes can also be seen at CDR 0 in MAPT mutation carriers within the limbic system. Our results suggest that subcortical brain volumes may be used as markers of neurodegeneration even prior to the onset of prodromal symptoms.
Published: 2021
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6. Democratic sequences

Author: Mathis, Anne Bertrand
Subjects: Mathematics - Combinatorics, 11K, G.3, G.4
Abstract: Given a countable alphabet and a sountable set pf preset frequency, we construct a sequence where each letter appears with the preaasigned frequency.
Published: 2024

7. Improved cerebral microbleeds detection using their magnetic signature on T2*-phase-contrast: A comparison study in a clinical setting

Author: Takoua Kaaouana, Anne Bertrand, Fatma Ouamer, Bruno Law-ye, Nadya Pyatigorskaya, Ali Bouyahia, Nathalie Thiery, Carole Dufouil, Christine Delmaire, Didier Dormont, Ludovic de Rochefort, and Marie Chupin
Subjects: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
Abstract: Introduction/purpose: In vivo detection of cerebral microbleeds (CMBs) from T2* gradient recalled echo (GRE) magnitude image suffers from low specificity, modest inter-rater reproducibility and is biased by its sensitivity to acquisition parameters. New methods were proposed for improving this identification, but they mostly rely on 3D acquisitions, not always feasible in clinical practice. A fast 2D phase processing technique for computing internal field maps (IFM) has been shown to make it possible to characterize CMBs through their magnetic signature in routine clinical setting, based on 2D multi-slice acquisitions. However, its clinical interest for CMBs identification with respect to more common images remained to be assessed. To do so, systematic experiments were undertaken to compare the ratings obtained by trained observers with several image types, T2* magnitude, Susceptibility Weighted Imaging reconstructions (SWI) and IFM built from the same T2*-weighted acquisition. Materials/methods: 15 participants from the MEMENTO multi-center cohort were selected: six subjects with numerous CMBs (20 ± 6 CMBs), five subjects with a few CMBs (2 ± 1 CMBs) and four subjects without CMB. 2D multi-slice T2* GRE sequences were acquired on Philips and Siemens 3T systems. After pilot experiments, T2* magnitude, Susceptibility Weighted Imaging (SWI) minimum intensity projection (mIP) on three slices and IFM were considered for the rating experiments. A graphical user interface (GUI) was designed in order to consistently display images in random order. Six raters of various background and expertise independently selected “definite” or “possible” CMBs. Rating results were compared with respect to a specific consensus reference, on both lesion and subject type points of view. Results: IFM yielded increased sensitivity and decreased false positives rate (FPR) for CMBs identification compared to T2* magnitude and SWI-mIP images. Inter-rater variability was decreased with IFM when identifying subjects with numerous lesions, with only a limited increase in rating time. IFM thus appears as an interesting candidate to improve CMBs identification in clinical setting. Keywords: Microbleeds, Magnetic susceptibility, Phase MRI, SWI
Published: 2017
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8. An Automated Pipeline for the Analysis of PET Data on the Cortical Surface

Author: Arnaud Marcoux, Ninon Burgos, Anne Bertrand, Marc Teichmann, Alexandre Routier, Junhao Wen, Jorge Samper-González, Simona Bottani, Stanley Durrleman, Marie-Odile Habert, Olivier Colliot, and for the Alzheimer's Disease Neuroimaging Initiative
Subjects: surface analysis, positron emission tomography, PET, brain, neurodegenerative diseases, workflow, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: We present a fully automatic pipeline for the analysis of PET data on the cortical surface. Our pipeline combines tools from FreeSurfer and PETPVC, and consists of (i) co-registration of PET and T1-w MRI (T1) images, (ii) intensity normalization, (iii) partial volume correction, (iv) robust projection of the PET signal onto the subject's cortical surface, (v) spatial normalization to a template, and (vi) atlas statistics. We evaluated the performance of the proposed workflow by performing group comparisons and showed that the approach was able to identify the areas of hypometabolism characteristic of different dementia syndromes: Alzheimer's disease (AD) and both the semantic and logopenic variants of primary progressive aphasia. We also showed that these results were comparable to those obtained with a standard volume-based approach. We then performed individual classifications and showed that vertices can be used as features to differentiate cognitively normal and AD subjects. This pipeline is integrated into Clinica, an open-source software platform for neuroscience studies available at www.clinica.run.
Published: 2018
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9. Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants

Author: Alexandre Routier, Marie-Odile Habert, Anne Bertrand, Aurélie Kas, Martina Sundqvist, Justine Mertz, Pierre-Maxime David, Hugo Bertin, Serge Belliard, Florence Pasquier, Karim Bennys, Olivier Martinaud, Frédérique Etcharry-Bouyx, Olivier Moreaud, Olivier Godefroy, Jérémie Pariente, Michèle Puel, Philippe Couratier, Claire Boutoleau-Bretonnière, Bernard Laurent, Raphaëlla Migliaccio, Bruno Dubois, Olivier Colliot, and Marc Teichmann
Subjects: primary progressive aphasias, cortical thickness, cortical metabolism, tracts, MRI, PET, Neurology. Diseases of the nervous system, RC346-429
Abstract: Neuroimaging studies have described the brain alterations in primary progressive aphasia (PPA) variants (semantic, logopenic, nonfluent/agrammatic). However, few studies combined T1, FDG-PET, and diffusion MRI techniques to study atrophy, hypometabolism, and tract alterations across the three PPA main variants. We therefore explored a large early-stage cohort of semantic, logopenic and nonfluent/agrammatic variants (N = 86) and of 23 matched healthy controls with anatomical MRI (cortical thickness), FDG PET (metabolism) and diffusion MRI (white matter tracts analyses), aiming at identifying cortical and sub-cortical brain alterations, and confronting these alterations across imaging modalities and aphasia variants. In the semantic variant, there was cortical thinning and hypometabolism in anterior temporal cortices, with left-hemisphere predominance, extending toward posterior temporal regions, and affecting tracts projecting to the anterior temporal lobes (inferior longitudinal fasciculus, uncinate fasciculus) and tracts projecting to or running nearby posterior temporal cortices: (superior longitudinal fasciculus, inferior frontal-occipital fasciculus). In the logopenic variant metabolic alterations were more extensive than atrophy affecting mainly the left temporal-parietal junction and extending toward more anterior temporal cortices. Metabolic and tract data were coherent given the alterations of the left superior and inferior longitudinal fasciculus and the left inferior frontal-occipital fasciculus. In the nonfluent/agrammatic variant cortical thinning and hypometabolism were located in the left frontal cortex but Broca's area was only affected on metabolic measures. Metabolic and tract alterations were coherent as reflected by damage to the left uncinate fasciculus connecting with Broca's area. Our findings provide a full-blown statistically robust picture of brain alterations in early-stage variants of primary progressive aphasia which has implications for diagnosis, classification and future therapeutic strategies. They demonstrate that in logopenic and semantic variants patterns of brain damage display a non-negligible overlap in temporal regions whereas they are substantially distinct in the nonfluent/agrammatic variant (frontal regions). These results also indicate that frontal networks (combinatorial syntax/phonology) and temporal networks (lexical/semantic representations) constitute distinct anatomo-functional entities with differential vulnerability to degenerative processes in aphasia variants. Finally, the identification of the specific damage patterns could open an avenue for trans-cranial stimulation approaches by indicating the appropriate target-entry into the damaged language system.
Published: 2018
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10. COGEVIS: A New Scale to Evaluate Cognition in Patients with Visual Deficiency

Author: Claire Meyniel, Dalila Samri, Farah Stefano, Joel Crevoisier, Florence Bonté, Raffaella Migliaccio, Laure Delaby, Anne Bertrand, Marie Odile Habert, Bruno Dubois, Bahram Bodaghi, and Stéphane Epelbaum
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: We evaluated the cognitive status of visually impaired patients referred to low vision rehabilitation (LVR) based on a standard cognitive battery and a new evaluation tool, named the COGEVIS, which can be used to assess patients with severe visual deficits. We studied patients aged 60 and above, referred to the LVR Hospital in Paris. Neurological and cognitive evaluations were performed in an expert memory center. Thirty-eight individuals, 17 women and 21 men with a mean age of 70.3 ± 1.3 years and a mean visual acuity of 0.12 ± 0.02, were recruited over a one-year period. Sixty-three percent of participants had normal cognitive status. Cognitive impairment was diagnosed in 37.5% of participants. The COGEVIS score cutoff point to screen for cognitive impairment was 24 (maximum score of 30) with a sensitivity of 66.7% and a specificity of 95%. Evaluation following 4 months of visual rehabilitation showed an improvement of Instrumental Activities of Daily Living (p=0.004), National Eye Institute Visual Functioning Questionnaire (p=0.035), and Montgomery–Åsberg Depression Rating Scale (p=0.037). This study introduces a new short test to screen for cognitive impairment in visually impaired patients.
Published: 2018
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11. IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates.

Author: Romina Aron Badin, Brigitte Spinnewyn, Marie-Claude Gaillard, Caroline Jan, Carole Malgorn, Nadja Van Camp, Frédéric Dollé, Martine Guillermier, Sabrina Boulet, Anne Bertrand, Marc Savasta, Michel Auguet, Emmanuel Brouillet, Pierre-Etienne Chabrier, and Philippe Hantraye
Subjects: Medicine, Science
Abstract: The development of dyskinesias following chronic L-DOPA replacement therapy remains a major problem in the long-term treatment of Parkinson's disease. This study aimed at evaluating the effect of IRC-082451 (base of BN82451), a novel multitargeting hybrid molecule, on L-DOPA-induced dyskinesias (LIDs) and hypolocomotor activity in a non-human primate model of PD. IRC-082451 displays multiple properties: it inhibits neuronal excitotoxicity (sodium channel blocker), oxidative stress (antioxidant) and neuroinflammation (cyclooxygenase inhibitor) and is endowed with mitochondrial protective properties. Animals received daily MPTP injections until stably parkinsonian. A daily treatment with increasing doses of L-DOPA was administered to parkinsonian primates until the appearance of dyskinesias. Then, different treatment regimens and doses of IRC-082451 were tested and compared to the benchmark molecule amantadine. Primates were regularly filmed and videos were analyzed with specialized software. A novel approach combining the analysis of dyskinesias and locomotor activity was used to determine efficacy. This analysis yielded the quantification of the total distance travelled and the incidence of dyskinesias in 7 different body parts. A dose-dependent efficacy of IRC-082451 against dyskinesias was observed. The 5 mg/kg dose was best at attenuating the severity of fully established LIDs. Its effect was significantly different from that of amantadine since it increased spontaneous locomotor activity while reducing LIDs. This dose was effective both acutely and in a 5-day sub-chronic treatment. Moreover, positron emission tomography scans using radiolabelled dopamine demonstrated that there was no direct interference between treatment with IRC-082451 and dopamine metabolism in the brain. Finally, post-mortem analysis indicated that this reduction in dyskinesias was associated with changes in cFOS, FosB and ARC mRNA expression levels in the putamen. The data demonstrates the antidyskinetic efficacy of IRC-082451 in a primate model of PD with motor complications and opens the way to the clinical application of this treatment for the management of LIDs.
Published: 2013
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12. Micro-MRI study of cerebral aging: ex vivo detection of hippocampal subfield reorganization, microhemorrhages and amyloid plaques in mouse lemur primates.

Author: Anne Bertrand, Adrien Pasquier, Alexandra Petiet, Christopher Wiggins, Audrey Kraska, Nelly Joseph-Mathurin, Fabienne Aujard, Nadine Mestre-Francés, and Marc Dhenain
Subjects: Medicine, Science
Abstract: Mouse lemurs are non-human primate models of cerebral aging and neurodegeneration. Much smaller than other primates, they recapitulate numerous features of human brain aging, including progressive cerebral atrophy and correlation between regional atrophy and cognitive impairments. Characterization of brain atrophy in mouse lemurs has been done by MRI measures of regional CSF volume and by MRI measures of regional atrophy. Here, we further characterize mouse lemur brain aging using ex vivo MR microscopy (31 µm in-plane resolution). First, we performed a non-biased, direct volumetric quantification of dentate gyrus and extended Ammon's horn. We show that both dentate gyrus and Ammon's horn undergo an age-related reorganization leading to a growth of the dentate gyrus and an atrophy of the Ammon's horn, even in the absence of global hippocampal atrophy. Second, on these first MR microscopic images of the mouse lemur brain, we depicted cortical and hippocampal hypointense spots. We demonstrated that their incidence increases with aging and that they correspond either to amyloid deposits or to cerebral microhemorrhages.
Published: 2013
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13. Correction: IRC-082451, a Novel Multitargeting Molecule, Reduces L-DOPA-Induced Dyskinesias in MPTP Parkinsonian Primates.

Author: Romina Aron Badin, Brigitte Spinnewyn, Marie-Claude Gaillard, Caroline Jan, Carole Malgorn, Nadja Van Camp, Frédéric Dollé, Martine Guillermier, Sabrina Boulet, Anne Bertrand, Marc Savasta, Michel Auguet, Emmanuel Brouillet, Pierre-Etienne Chabrier, and Philippe Hantraye
Subjects: Medicine, Science
Published: 2013
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14. Magnetic resonance imaging in primates. The example of the mouse lemur (Microcebus murinus): From detection of pathological aging to therapeutic evaluations

Author: Nelly Joseph-Mathurin, Olene Dorieux, Audrey Kraska, Anne Bertrand, Mathieu Santin, Nadine El Tannir El Tayara, and Marc Dhenain
Subjects: aging, Alzheimer, imaging, mouse lemur, MRI, primates, Science, Zoology, QL1-991
Abstract: Cerebral aging is a major public health issue in our societies as the aged population increases dramatically. It leads in many cases to neurodegenerative diseases such as Alzheimer disease (AD). Rodents and particularly transgenic mice are widely used as models for research on physiopathology of cerebral aging, neurodegenerative diseases and for the evaluation of therapies. However these models do not mimic all the pathophysiological aspects of human diseases. Complementary models such as non-human primates are phylogenetically close to humans and thus more predictive of drug efficiency in humans. Mouse lemur (Microcebus murinus) is a small primate (about 12cm, 100g) described as a useful model of cerebral aging and as a potential model of AD. Indeed several animals develop age-associated cerebral alterations like amyloidosis and other cerebral changes. Non invasive medical imaging methods such as magnetic resonance imaging (MRI) can be used to follow-up brain changes in these animals. In this review, we present how mouse lemurs can be followed-up by MRI and how MRI can be used during therapeutic evaluations and other applications in this model. MR images can be used to follow-up cerebral anatomy in mouse lemurs. It allows for the description of age-associated atrophic processes, age-associated iron accumulation, and vascular anatomy (thanks to MR angiography). Cerebral glucose uptake can be studied in mouse lemurs with other in vivo imaging modalities such as positron emission tomography (PET). In this case, MRI can be used as a support for quantification of radioligand uptake in specific structures. Ex vivo MR imaging is another MR protocol that can be used to describe cerebral aging in lemurs. It provides high resolution 3D histological brain images and allows for studying exquisite anatomical details or microhemorrhages. Finally, MRI can be used to practice cerebral surgery in lemurs and determine coordinates for stereotactic injections. It can also be used during therapeutic interventions by selecting animals to be involved in therapeutic trials and also by following specific MR biomarkers. MRI is thus critical to better characterize cerebral aging in the mouse lemur and to better carry out longitudinal studies in this primate model.
Published: 2011
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15. Reproducible Evaluation of Diffusion MRI Features for Automatic Classification of Patients with Alzheimer's Disease.

Author: Junhao Wen, Jorge Samper-González, Simona Bottani, Alexandre Routier, Ninon Burgos, Thomas Jacquemont, Sabrina Fontanella, Stanley Durrleman, Stéphane Epelbaum, Anne Bertrand, and Olivier Colliot
Published: 2021
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16. Individual Analysis of Molecular Brain Imaging Data Through Automatic Identification of Abnormality Patterns.

Author: Ninon Burgos, Jorge Samper-González, Anne Bertrand, Marie Odile Habert, Sébastien Ourselin, Stanley Durrleman, M. Jorge Cardoso, and Olivier Colliot
Published: 2017
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17. Accuracy of MRI Classification Algorithms in a Tertiary Memory Center Clinical Routine Cohort.

Author: Alexandre Morin, Jorge Samper-González, Anne Bertrand, Sebastian Ströer, Didier Dormont, Aline Mendes, Pierrick Coupé, Jamila Ahdidan, Marcel Lévy, Dalila Samri, Harald Hampel, Bruno Dubois, Marc Teichmann, Stéphane Epelbaum, and Olivier Colliot
Published: 2020

18. Reproducible evaluation of classification methods in Alzheimer's disease: Framework and application to MRI and PET data.

Author: Jorge Samper-González, Ninon Burgos, Simona Bottani, Sabrina Fontanella, Pascal Lu, Arnaud Marcoux, Alexandre Routier, Jérémy Guillon, Michael Bacci, Junhao Wen, Anne Bertrand, Hugo Bertin, Marie Odile Habert, Stanley Durrleman, Theodoros Evgeniou, and Olivier Colliot
Published: 2018
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19. Bice Curiger

Author: Anne Bertrand
Subjects: General Engineering
Published: 2022

20. Brain Connectivity Alterations Are Associated with the Development of Dementia in Parkinson's Disease.

Author: Josie-Anne Bertrand, Anthony Randal McIntosh, Ronald B. Postuma, Natasa Kovacevic, Véronique Latreille, Michel Panisset, Sylvain Chouinard, and Jean-François Gagnon
Published: 2016
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21. Reproducible evaluation of diffusion MRI features for automatic classification of patients with Alzheimers disease.

Author: Junhao Wen, Jorge Samper-González, Simona Bottani, Alexandre Routier, Ninon Burgos, Thomas Jacquemont, Sabrina Fontanella, Stanley Durrleman, Stéphane Epelbaum, Anne Bertrand, and Olivier Colliot
Published: 2018

22. Auteurs de la 5e édition

Author: Benoît, Allenet, primary, Thomas, Aparicio, additional, Xavier, Armoiry, additional, Nathalie, Asseray, additional, Gilles, Aulagner, additional, Astrid, Bacle, additional, Jean-Didier, Bardet, additional, Aurélie, Barrail-Tran, additional, Marie, Batisse, additional, Magalie, Baudrant, additional, Pierrick, Bedouch, additional, Yannick, Béjot, additional, Johnny, Beney, additional, Lise, Bernard, additional, Florian, Bernard-Arnoux, additional, Philippe, Bertin, additional, Marie-Anne, Bertrand, additional, Guillaume, Binson, additional, Thomas, Bochaton, additional, Laurence, Bonhomme-Faivre, additional, Pascal, Bonnabry, additional, Aurélie, Bonvin, additional, Roselyne, Boulieu, additional, Mathieu, Boulin, additional, Elsa, Bourcier, additional, Olivier, Bourdon, additional, Amélie, Boursier, additional, Michel, Brazier, additional, Valentine, Bréant, additional, Dominique, Breilh, additional, Françoise, Brion, additional, Olivier, Bugnon, additional, Cécile, Burgos Leon, additional, Marion, Buyse, additional, Jean, Calop, additional, Nathalie, Calop, additional, Pauline, Calvet, additional, Aude, Capelle, additional, Philippe, Caron, additional, Audrey, Castet-Nicolas, additional, Jean-Louis, Cazin, additional, Philippe, Cestac, additional, Sébastien, Chanoine, additional, Claire, Chapuis, additional, Alexandre, Charmillon, additional, Fiona, Chautant, additional, Hacène, Chekroud, additional, Anne-Laure, Clairet, additional, Chantal, Csajka, additional, Béatrice, Demoré, additional, François, Derimay, additional, Jean-Luc, Diehl, additional, Thierry, Dine, additional, Xavier, Dode, additional, Virginie, Dousset, additional, Antoine, Dupuis, additional, Raphaël, Duval, additional, Philippe, Fagnoni, additional, Patrice, Fardellone, additional, Christine, Fernandez, additional, Alexandra, Fournel, additional, Blandine, Gérard, additional, Stéphane, Gibaud, additional, François, Goehringer, additional, Marion, Grare, additional, Jean, Grellet, additional, Pauline, Gueneau, additional, Bertrand, Guignard, additional, Aline, Hajj, additional, Souheil, Hallit, additional, Sylvie, Hansel-Esteller, additional, Raoul, Herbrecht, additional, Patrick, Hindlet, additional, Stéphane, Honoré, additional, Jean-François, Huon, additional, Audrey, Janoly-Dumenil, additional, Jeremy, Jost, additional, Pierre, Jouanny, additional, Jean-Daniel, Kaiser, additional, Laurent, Kodjikian, additional, Diane, Korb, additional, Virginie, Korb-Savoldelli, additional, Charlotte, Laborde, additional, Magali, Larger, additional, Gwenaël, Le Moal, additional, Paul, Le Turnier, additional, François, Lebargy, additional, Audrey, Lehmann, additional, Florian, Lemaitre, additional, Joël, Leroy, additional, Dominique, Levêque, additional, Samuel, Limat, additional, Louise, Malet, additional, Marine, Manuelli, additional, Nicolas, Marie, additional, Aurélien, Mary, additional, Martial, Mercié, additional, Florence, Meyer, additional, Frédéric, Mille, additional, Pauline, Mondoloni, additional, Céline, Mongaret Kossmann, additional, Tess, Monnot, additional, David, Montani, additional, Jean-François, Mornex, additional, Philippe, Moulin, additional, Florian, Naudet, additional, Dominique, Navas, additional, Virginie, Nerich, additional, Yasmine, Nivoix, additional, Hélène, Ottomani, additional, Arnaud, Pagès, additional, Hélène, Peyrière, additional, Isabelle, Pin, additional, Christophe, Pison, additional, Stéphane, Ploteau, additional, Laudine, Potie, additional, Sophie, Potin, additional, Sonia, Prot-Labarthe, additional, Florent, Puisset, additional, Céline, Pulcini, additional, Pauline, Quillet, additional, Alain, Ragon, additional, Stéphanie, Ragot, additional, Voa, Ratsimbazafy, additional, Philippe, Reix, additional, Pierre, Renaudin, additional, Anne, Rouault, additional, Laure, Rouch, additional, Matthieu, Roustit, additional, Brigitte, Sabatier, additional, Hala, Sacre, additional, Pascale, Salameh, additional, Brigitte, Sallerin, additional, Valérie, Sautou, additional, Pascale, Sebahoun, additional, Laurent, Sebbag, additional, Igor, Tauveron, additional, Aurélie, Terrier-Lenglet, additional, Camille, Tron, additional, Hervé, Trout, additional, Geneviève, Ubeaud-Séquier, additional, Nicolas, Venisse, additional, Sandrine, Venisse, additional, Pascale, Vergne-Salle, additional, and Sandra, Vukusic, additional
Published: 2018
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23. Primary progressive aphasias associated with C9orf72 expansions: Another side of the story

Author: idier Hannequin, Eino Solje, Sabrina Sayah, Emmanuel Gerardin, Marie Sarazin, Florence Pasquier, Marion Houot, Assi-Hervé Oya, Martine Vercelletto, Julien Lagarde, Marie Noguès-Lassiaille, Marie Chupin, Vincent Deramecourt, Sophie Auriacombe, Agnès Camuzat, Marc Teichmann, Jérémie Pariente, Sophie Ferrieux, Lucette Lacomblez, Mathieu Chastan, Jacques Monteil, Yaohua Chen, Marie-Paule Boncoeur, Lorenzo Cipriano, Anne Bissery, Simona Bottani, David Wallon, Christine Delmaire, Carole Roué-Jagot, Benjamin Le Toullec, Bernard-François Michel, Grégory Petyt, Olivier Martinaud, Philippe Couratier, Dario Saracino, Adeline Rollin-Sillaire, Daisy Rinaldi, Mira Didic, Serge Belliard, Amandine Géraudie, Géraldine Lautrette, Frédérique Etcharry-Bouyx, Xavier Delbeuck, Richard Levy, Frédéric Blanc, Mathieu Ceccaldi, Christel Thauvin-Robinet, Marie-Odile Habert, Eve Benchetrit, Maïté Formaglio, Alexis Brice, Isabelle Le Ber, Charles Duyckaerts, Véronique Golfier, Raffaella Migliaccio, Marie-Anne Mackowiak, Catherine Thomas-Antérion, Anne Bertrand, Olivier Colliot, François Sellal, Claire Boutoleau-Bretonnière, Anne M. Remes, Hugo Bertin, Aurélie Funkiewiez, and Stéphanie Bombois
Subjects: medicine.medical_specialty, C9orf72 Protein, Apraxias, Cognitive Neuroscience, Inferior frontal gyrus, Experimental and Cognitive Psychology, Frontotemporal lobar degeneration, respiratory system, Audiology, medicine.disease, Magnetic Resonance Imaging, Apraxia, Primary progressive aphasia, Aphasia, Primary Progressive, Neuropsychology and Physiological Psychology, Atrophy, C9orf72, medicine, Humans, Speech, Orbitofrontal cortex, Psychology, Language, Frontotemporal dementia
Abstract: C9orf72 repeat expansions are rarely associated with primary progressive aphasias (PPA). In-depth characterization of the linguistic deficits, and the underlying patterns of grey-matter atrophy in PPA associated with the C9orf72 expansions (PPA-C9orf72) are currently lacking. In this study, we comprehensively analyzed a unique series of 16 patients affected by PPA-C9orf72. Eleven patients were issued from two independent French and Finnish cohorts, and five were identified by means of literature review. Voxel-based morphometry (VBM) studies were performed on three of them. This study depicts the spectrum of C9orf72–related aphasic phenotypes, and illustrates their linguistic presentation. The non-fluent/agrammatic variant was the most frequent phenotype in our series (9/16 patients, 56%), with apraxia of speech being the main defining feature. Left frontal lobe atrophy was present in these subjects, peaking in inferior frontal gyrus. Three patients (19%) showed the semantic variant, with progression of atrophy in temporo-polar regions, later involving orbitofrontal cortex. Anterior temporal lobe dysfunction was also particularly relevant in two patients (12.5%) with mixed forms of PPA. Lastly, two patients (12.5%) had unclassifiable PPA with predominating word-finding difficulties. No PPA-C9orf72 patients in our series fulfilled the criteria of the logopenic variant. Importantly, this study underlines the role of C9orf72 mutation in the disruption of the most anterior parts of the language network, including prefrontal and temporo-polar areas. It provides guidelines for C9orf72 testing in PPA patients, with important clinical impact as gene-specific therapies are upcoming.
Published: 2021

24. The profession of neuropsychologist in Canada: Findings of a national survey

Author: Diego Rivera, Sebastien Monette, Juan Carlos Arango-Lasprilla, Josie-Anne Bertrand, Daniela Ramos-Usuga, and Elisabeth Perreau-Linck
Subjects: Adult, Male, Employment, Canada, medicine.medical_specialty, Referral, medicine.medical_treatment, Population, Neuropsychological Tests, Arts and Humanities (miscellaneous), Neuropsychology, Surveys and Questionnaires, Developmental and Educational Psychology, medicine, Humans, Child, education, education.field_of_study, Rehabilitation, business.industry, Public sector, Clinical supervision, Psychiatry and Mental health, Clinical Psychology, Clinical neuropsychology, Neuropsychology and Physiological Psychology, Family medicine, Female, business, Psychology, Neurocognitive
Abstract: The purpose of this study was to investigate the demographic characteristics, academic training and types of professional activities of clinical neuropsychologists in Canada. 282 participants completed an online-based survey. Respondents were women for the most part and had a mean age of 43 years. They typically had doctoral-level training (85%) and about one-quarter had postdoctoral training (23%). Nearly half (47%) had a lifespan practice, over one-third (37%) had an adults-only practice, and about one-sixth (16%) had an exclusively pediatric practice. Most worked full-time (79%). Respondents were almost evenly split three ways between those who worked in the public sector, those who worked in the private sector, and those who worked in both. The most common professional activities related to assessment (95%), although clinical supervision (43%) and rehabilitation (42%) were also quite frequent, whereas research (27%) and teaching (18%) were less so. The most common reason for referral was to determine a diagnosis (79%). Pediatric neuropsychologists worked primarily with individuals with neurodevelopmental disorders and neuropsychologists working with adult populations worked primarily with individuals with emotional disorders, acquired neuropsychological disorders (traumatic brain injury, stroke/vascular), and neurocognitive disorders (dementia). At time of study, Canadian neuropsychologists seemed to enjoy a fairly balanced situation: Their level of training and the ratio of neuropsychologists per population were both high. However, these varied widely across Canada. This suggests that the profession and public interest would stand to gain from seeing training standardized to some extent nationwide.
Published: 2021

25. The role of semantic memory in prospective memory and episodic future thinking: new insights from a case of semantic dementia

Author: Anne Bertrand, Sophie Ferrieux, Maria Abram, Bruno Dubois, Valentina La Corte, Marc Teichmann, and Pascale Piolino
Subjects: Cognitive science, Memory, Episodic, Semantic dementia, medicine.disease, Semantics, Thinking, Arts and Humanities (miscellaneous), Frontotemporal Dementia, Mental Recall, Prospective memory, medicine, Humans, Semantic memory, Psychology, Episodic memory, General Psychology
Abstract: Prospective memory (PM), the ability to remember to execute planned actions, and episodic future thinking (EFT), the ability to imagine future personal events, are two core aspects of future-oriented cognition. The present study aimed for the first time at examining the role of semantic memory loss in PM and EFT in a single case patient (SL) at the early stage of semantic dementia.First, we investigated various types of PM as well as episodic memory of new events using a validated ecological assessment via virtual reality. Second, we examined EFT using a temporally extended version of the TEMPau task, which measures episodic aspects of remembering the past and imagining the future taking temporal distance into account.Patient SL was deficient in semantically linked event-based PM and was unable to provide any EFT for the most distant period but was preserved in other types of PM and near and intermediate EFT.These findings provide new evidence on the role of semantic memory in PM depending on the type of intention and in EFT depending on the temporal distance mirroring autobiographical memory. Finally, they point out a specific link between PM and near EFT in future-oriented cognition.
Published: 2021

26. Recognizing an Object from the Sum of Its Parts: An Intracranial Study on Alpha Rhythms.

Author: Josie-Anne Bertrand, Julie Tremblay, Maryse Lassonde, Phetsamone Vannasing, Dang Khoa Nguyen, Manon Robert, Alain Bouthillier, and Franco Lepore
Published: 2014
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27. Nobody’s Perfect

Author: Klok, Anne Bertrand, Yurika Aonuki, Sihwei Chen, Henry Davis, Joash Gambarage, Laura Griffin, Marianne Huijsmans, Lisa Matthewson, Daniel Reisinger, Hotze Rullmann, Raiane Salles, Michael David Schwan, Neda Todorović, Bailey Trotter, and Jozina Vander
Subjects: tense, aspect, perfect, perfective, experiential, resultative, storyboards, typology
Abstract: This paper challenges the cross-linguistic validity of the tense–aspect category ‘perfect’ by investigating 15 languages from eight different families (Atayal, Brazilian Portuguese, Dutch, English, German, Gitksan, Japanese, Javanese, Korean, Mandarin, Niuean, Québec French, St’át’imcets, Swahili, and Tibetan). The methodology involves using the storyboard ‘Miss Smith’s Bad Day’ to test for the availability of experiential, resultative, recent-past, and continuous readings, as well as lifetime effects, result-state cancellability, narrative progression, and compatibility with definite time adverbials. Results show that the target forms in these languages can be classified into four groups: (a) past perfectives; (b) experientials; (c) resultatives; and (d) hybrids (which allow both experiential and resultative readings). It is argued that the main division is between past perfectives, which contain a ‘pronominal’ tense, on the one hand, and the other three groups on the other, which involve existential quantification, either over times (experiential) or over events (resultative). The methodological and typological implications of the findings are discussed. The main conclusion of the study is that there is no universal category of ‘the perfect’, and that instead, researchers should focus on identifying shared semantic components of tense–aspect categories across languages.
Published: 2022
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28. Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI.

Author: Anne Bertrand, Umer Khan, Dung Minh Hoang, Dmitry S. Novikov, Pavan Krishnamurthy, Hameetha B. Rajamohamed Sait, Benjamin W. Little, Einar M. Sigurdsson, and Youssef Zaim Wadghiri
Published: 2013
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29. Sur Les Parties Fractionnaires Des Suites (β n ) n ≥1

Author: Anne Bertrand-Mathis
Subjects: Discrete mathematics, Probability and statistics, General Medicine, Mathematics
Abstract: We show that for an arbitrary sequence of intervals I n with constant length c, there exist real numbers β such that for all n β n belongs to I n modulo one.
Published: 2019

30. Childhood cognitive skill trajectories and suicide by mid-adulthood: an investigation of the 1958 British Birth Cohort

Author: Marie-Claude Geoffroy, Kyle T. Greenway, Massimiliano Orri, Stéphane Richard-Devantoy, Josie-Anne Bertrand, Gustavo Turecki, Chris Power, David Gunnell, McGill Group for Suicide Studies, McGill University = Université McGill [Montréal, Canada]-Douglas Mental Health University Institute, CISSS des Laurentides, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Douglas Research Center, Douglas Mental Health University Institute, Population Health Sciences [Bristol, Royaume-Uni], University of Bristol [Bristol], National Institute of Health Research Biomedical Research Centre [Bristol], University of Bristol [Bristol]-NHS Foundation Trust-University Hospitals Bristol, UCL Great Ormond Street Institute of Child Health [London, UK], Department of educational and counselling psychology, McGill University = Université McGill [Montréal, Canada], DG is supported by the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol, England. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health and Social Care. MO is supported by the European Union's Horizon 2020 research and innovation program under grant agreement No. 793396 and the Canadian Institutes of Health Research. MCG holds a Canada Research Chair (Tier 2) and is supported by the American Foundation for Suicide Prevention (AFSP). Dr Turecki holds a Canada Research Chair (Tier 1) and a NARSAD Distinguished Investigator Award. He is supported by grants from the Canadian Institute of Health Research (CIHR) (FDN148374 and EGM141899). Drs Geoffroy and Turecki are supported by the Fonds de recherche du Québec – Santé (FRQS) through the Quebec Network on Suicide, Mood Disorders and Related Disorders., and European Project: 793396,LIFESPAN
Subjects: Male, Longitudinal study, Adolescent, Intelligence, Poison control, Suicide, Attempted, Suicide prevention, Occupational safety and health, Cohort Studies, 03 medical and health sciences, Cognition, 0302 clinical medicine, Cognitive Abilities, Academic Performance, Injury prevention, Humans, Longitudinal Studies, Cognitive skill, Child, Applied Psychology, Intelligence Tests, Human factors and ergonomics, Middle Aged, United Kingdom, 030227 psychiatry, Suicide, Early-life influences, Psychiatry and Mental health, Reading, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Female, Mathematics, Birth cohort, 030217 neurology & neurosurgery, Demography, Cohort study
Abstract: BackgroundPoor cognitive abilities and low intellectual quotient (IQ) are associated with an increased risk of suicide attempts and suicide mortality. However, knowledge of how this association develops across the life-course is limited. Our study aims to establish whether individuals who died by suicide by mid-adulthood are distinguishable by their child-to-adolescence cognitive trajectories.MethodsParticipants were from the 1958 British Birth Cohort and were assessed for academic performance at ages 7, 11, and 16 and intelligence at 11 years. Suicides occurring by September 2012 were identified from linked national death certificates. We compared mean mathematics and reading abilities and rate of change across 7–16 years for individuals who died by suicide v. those still alive, with and without adjustment for potential early-life confounding factors. Analyses were based on 14 505 participants.ResultsFifty-five participants (48 males) had died by suicide by age 54 years. While males who died by suicide did not differ from participants still alive in reading scores at age 7 [effect size (g) = −0.04, p = 0.759], their reading scores had a less steep improvement up to age 16 compared to other participants. Adjustments for early-life confounding factors explained these differences. A similar pattern was observed for mathematics scores. There was no difference between individuals who died by suicide v. participants still alive on intelligence at 11 years.ConclusionsWhile no differences in tests of academic performance and IQ were observed, individuals who died by suicide had a less steep improvement in reading abilities over time compared to same-age peers.
Published: 2019

31. Intermittent Hypoxia Rewires the Liver Transcriptome and Fires up Fatty Acids Usage for Mitochondrial Respiration

Author: Jonathan Gaucher, Guillaume Vial, Emilie Montellier, Maëlle Guellerin, Sophie Bouyon, Emeline Lemarie, Véronique Pelloux, Anne Bertrand, Karin Pernet-Gallay, Frederic Lamarche, Anne-Laure Borel, Claire Arnaud, Elise Belaidi, Karine Clément, Diane Godin Ribuot, Judith Aron-Wisnewsky, and Jean-Louis Pépin
Subjects: mitochondria, Medicine (General), Nuclear Respiratory Factor (NRF), R5-920, intermittent hypoxia (IH), General Medicine, sleep apnea, liver, transcriptome
Abstract: Sleep Apnea Syndrome (SAS) is one of the most common chronic diseases, affecting nearly one billion people worldwide. The repetitive occurrence of abnormal respiratory events generates cyclical desaturation-reoxygenation sequences known as intermittent hypoxia (IH). Among SAS metabolic sequelae, it has been established by experimental and clinical studies that SAS is an independent risk factor for the development and progression of non-alcoholic fatty liver disease (NAFLD). The principal goal of this study was to decrypt the molecular mechanisms at the onset of IH-mediated liver injury. To address this question, we used a unique mouse model of SAS exposed to IH, employed unbiased high-throughput transcriptomics and computed network analysis. This led us to examine hepatic mitochondrial ultrastructure and function using electron microscopy, high-resolution respirometry and flux analysis in isolated mitochondria. Transcriptomics and network analysis revealed that IH reprograms Nuclear Respiratory Factor- (NRF-) dependent gene expression and showed that mitochondria play a central role. We thus demonstrated that IH boosts the oxidative capacity from fatty acids of liver mitochondria. Lastly, the unbalance between oxidative stress and antioxidant defense is tied to an increase in hepatic ROS production and DNA damage during IH. We provide a comprehensive analysis of liver metabolism during IH and reveal the key role of the mitochondria at the origin of development of liver disease. These findings contribute to the understanding of the mechanisms underlying NAFLD development and progression during SAS and provide a rationale for novel therapeutic targets and biomarker discovery.
Published: 2021

32. Traces of algebraic integers and dynamical systems.

Author: Anne Bertrand-Mathis
Published: 2007
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33. Optimal target VOI size for accurate 4D coregistration of DCE-MRI.

Author: Brian Park, Artem Mikheev, Youssef Zaim Wadghiri, Anne Bertrand, Dmitry S. Novikov, Hersh Chandarana, and Henry Rusinek
Published: 2016
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34. SLITRK2, an X-linked modifier of the age at onset in C9orf72 frontotemporal lobar degeneration

Author: Barbier, Mathieu, Camuzat, Agnès, Hachimi, Khalid El, Guegan, Justine, Rinaldi, Daisy, Lattante, Serena, Houot, Marion, Sánchez-Valle, Raquel, Sabatelli, Mario, Antonell, Anna, Molina-Porcel, Laura, Clot, Fabienne, Couratier, Philippe, van der Ende, Emma, van der Zee, Julie, Manzoni, Claudia, Camu, William, Cazeneuve, Cécile, Sellal, François, Didic, Mira, Golfier, Véronique, Pasquier, Florence, Duyckaerts, Charles, Rossi, Giacomina, Bruni, Amalia C, Alvarez, Victoria, Gómez-Tortosa, Estrella, de Mendonça, Alexandre, Graff, Caroline, Masellis, Mario, Nacmias, Benedetta, Oumoussa, Badreddine Mohand, Jornea, Ludmila, Forlani, Sylvie, Van Deerlin, Viviana, Rohrer, Jonathan D, Gelpi, Ellen, Rademakers, Rosa, Van Swieten, John, Le Guern, Eric, Van Broeckhoven, Christine, Ferrari, Raffaele, Génin, Emmanuelle, Brice, Alexis, Ber, Le, Isabelle Alexis Brice, Sophie, Auriacombe, Serge, Belliard, Anne, Bertrand, Anne, Bissery, Fre ́ de, ́ ric Blanc, Marie-Paule, Boncoeur, Ste, ́ phanie Bombois, Claire Boutoleau-Bretonnie` re, Agne`, s Camuzat, Mathieu, Ceccaldi, Marie, Chupin, Philippe, Couratier, Olivier, Colliot, Vincent, Deramecourt, Mira, Didic, Bruno, Dubois, Charles, Duyckaerts, Fre ́ de, ́ rique Etcharry-Bouyx, Aure, ́ lie Guignebert-Funkiewiez, Maı ̈te, ́ Formaglio, ́ ronique Golfier, Ve, Marie-Odile, Habert, Didier, Hannequin, Lucette, Lacomblez, Julien, Lagarde, ́ raldine Lautrette, Ge, Isabelle Le Ber, Benjamin Le Toullec, Richard, Levy, Marie-Anne, Mackowiak, Bernard-Franc ̧ois Michel, Florence, Pasquier, Thibaud, Lebouvier, Carole Roue, ́ -Jagot, Christel Thauvin- Robinet, Catherine, Thomas-Anterion, Je ́ re, ́ mie Pariente, Franc ̧ois Salachas, Sabrina, Sayah, Franc ̧ois Sellal, Assi-Herve, ́ Oya, Daisy, Rinaldi, Adeline, Rollin-Sillaire, Martine, Vercelletto, David, Wallon, Armelle, Rametti-Lacroux, Raffaele, Ferrari, Hernandez, Dena G., Nalls, Michael A., Rohrer, Jonathan D., Adaikalavan, Ramasamy, Kwok, John B. J., Carol Dobson- Stone, Brooks, William S., Schofield, Peter R., Halliday, Glenda M., Hodges, John R., Olivier, Piguet, Lauren, Bartley, Elizabeth, Thompson, Isabel Herna, ́ ndez, Agustı ́n Ruiz, Merce`, Boada, Barbara, Borroni, Alessandro, Padovani, Carlos, Cruchaga, Cairns, Nigel J., Luisa, Benussi, Giuliano, Binetti, Roberta, Ghidoni, Gianluigi, Forloni, Diego, Albani, Daniela, Galimberti, Chiara, Fenoglio, Maria, Serpente, Elio, Scarpini, ́ n, Jordi Clarimo, Alberto Lleo, ́, Rafael, Blesa, Maria Landqvist Waldo, ̈, Karin, Nilsson, Christer, Nilsson, Mackenzie, Ian R. A., Hsiung, Ging-Yuek R., Mann, David M. A., Jordan, Grafman, Morris, Christopher M., Johannes, Attems, Griffiths, Timothy D., Mckeith, Ian G., Thomas, Alan J., Pietro, Pietrini, Edward, Uey, Wassermann, Eric M., Atik, Baborie, Evelyn, Jaros, Tierney, Michael C., Pau, Pastor, Cristina, Razquin, Sara, Ortega-Cubero, Elena, Alonso, Robert, Perneczky, Janine, Diehl-Schmid, Panagiotis, Alexopoulos, Alexander, Kurz, Rainero, Innocenzo, Rubino, Elisa, Pinessi, Lorenzo, Ekaterina, Rogaeva, Peter St George-Hyslop, Giacomina, Rossi, Fabrizio, Tagliavini, Giorgio, Giaccone, Rowe, James B., Schlachetzki, Johannes C. M., James, Uphill, John, Collinge, Simon, Mead, Adrian, Danek, Van Deerlin, Vivianna M., Murray, Grossman, Trojanowski, John Q., Julie van der Zee, Christine Van Broeckhoven, Cappa, Stefano F., Isabelle, Leber, Alexis, Brice, Benedetta, Nacmias, Sandro, Sorbi, Silvia, Bagnoli, Irene, Piaceri, Nielsen, Jørgen E., Hjermind, Lena E., Matthias, Riemenschneider, Manuel, Mayhaus, Bernd, Ibach, Gilles, Gasparoni, Sabrina, Pichler, Wei, Gu, Rossor, Martin N., Fox, Nick C., Warren, Jason D., Maria Grazia Spillantini, Morris, Huw R., Patrizia, Rizzu, Peter, Heutink, Snowden, Julie S., Sara, Rollinson, Anna, Richardson, Alexander, Gerhard, Bruni, Amalia C., Raffaele, Maletta, Francesca, Frangipane, Chiara, Cupidi, Livia, Bernardi, Maria, Anfossi, Maura, Gallo, Maria Elena Conidi, Nicoletta, Smirne, Rosa, Rademakers, Matt, Baker, Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., David, Knopman, Josephs, Keith A., Boeve, Bradley F., Parisi, Joseph E., Seeley, William W., Miller, Bruce L., Karydas, Anna M., Howard, Rosen, van Swieten, John C., Dopper, Elise G. P., Harro, Seelaar, Pijnenburg, Yolande A. L., Philip, Scheltens, Giancarlo, Logroscino, Rosa, Capozzo, Valeria, Novelli, Puca, Annibale A., Massimo, Franceschi, Alfredo, Postiglione, Graziella, Milan, Paolo, Sorrentino, Mark, Kristiansen, Huei-Hsin, Chiang, Caroline, Graff, Adeline, Rollin, Dimitrios, Kapogiannis, Luigi, Ferrucci, Stuart, Pickering-Brown, Singleton, Andrew B., John, Hardy, Parastoo, Momeni., Neurology, Amsterdam Neuroscience - Neurodegeneration, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] (CIC Paris-Est), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Hôpital Dupuytren [CHU Limoges], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Center for Molecular Neurology (VIB-UAntwerp), University of Antwerp (UA), University College of London [London] (UCL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Neurologie [Hôpitaux Civils de Colmar], Hôpitaux Civils Colmar, Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Yves le Foll, Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Regional Neurogenetic Centre [Lamezia Terme, Italy] (CRN - ASP Catanzaro), Hospital Central de Asturias, Institute of Health Research of Principado de Asturias (ISPA), Fundación Jiménez Díaz, Fundacion Jimenez Diaz [Madrid] (FJD), Faculdade de Medicina [Lisboa], Universidade de Lisboa = University of Lisbon (ULISBOA), Karolinska University Hospital [Stockholm], Sunnybrook Research Institute [Toronto] (SRI), Sunnybrook Health Sciences Centre, Università degli Studi di Firenze = University of Florence (UniFI), Fondazione Don Carlo Gnocchi, Plateforme Post-génomique de la Pitié-Salpêtrière (PASS-P3S), Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé (PASS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Hospital of the University of Pennsylvania (HUP), Perelman School of Medicine, University of Pennsylvania-University of Pennsylvania, Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerpen, Belgium, Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), The French clinical and genetic Research network on FTLD/FTLD-ALS and PREVDEMALS, The International Frontotemporal Dementia Genomics Consortium, The European Early Onset Dementia (EU -EOD) Consortium, Brainbank Neuro-CEB Neuropathology Network, and Neurological Tissue Bank of the Biobank Hospital Clinic-IDIBAPS
Subjects: Adult, Male, TDP-43, C9orf72, SLITRK2, amyotrophic lateral sclerosis, frontotemporal dementia, Nerve Tissue Proteins, Settore MED/03 - GENETICA MEDICA, Polymorphism, Single Nucleotide, Cohort Studies, Genes, X-Linked, 80 and over, Medicine, Dementia, Humans, Allele, Age of Onset, Polymorphism, Aged, Aged, 80 and over, biology, C9orf72 Protein, business.industry, Membrane Proteins, MESH: Frontotemporal Lobar Degeneration / epidemiology, Frontotemporal Lobar, Degeneration / genetics, Genes, X-Linked / genetics, Genome-Wide Association Study / methods, Frontotemporal lobar degeneration, Single Nucleotide, Middle Aged, X-Linked, medicine.disease, Amyotrophic lateral sclerosis, Minor allele frequency, Genes, Immunology, Synaptophysin, biology.protein, Female, MESH: Adult, C9orf72 Protein / genetics, Frontotemporal Lobar Degeneration / diagnosis, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Human medicine, Neurology (clinical), MESH: Humans, Membrane Proteins / genetics, Nerve Tissue Proteins / genetics, Polymorphism, Single Nucleotide / genetics, Age of onset, Frontotemporal Lobar Degeneration, business, Frontotemporal dementia, Genome-Wide Association Study
Abstract: The G4C2-repeat expansion in C9orf72 is the most common cause of frontotemporal dementia and of amyotrophic lateral sclerosis. The variability of age at onset and phenotypic presentations is a hallmark of C9orf72 disease. In this study, we aimed to identify modifying factors of disease onset in C9orf72 carriers using a family-based approach, in pairs of C9orf72 carrier relatives with concordant or discordant age at onset. Linkage and association analyses provided converging evidence for a locus on chromosome Xq27.3. The minor allele A of rs1009776 was associated with an earlier onset (P = 1 × 10−5). The association with onset of dementia was replicated in an independent cohort of unrelated C9orf72 patients (P = 0.009). The protective major allele delayed the onset of dementia from 5 to 13 years on average depending on the cohort considered. The same trend was observed in an independent cohort of C9orf72 patients with extreme deviation of the age at onset (P = 0.055). No association of rs1009776 was detected in GRN patients, suggesting that the effect of rs1009776 was restricted to the onset of dementia due to C9orf72. The minor allele A is associated with a higher SLITRK2 expression based on both expression quantitative trait loci (eQTL) databases and in-house expression studies performed on C9orf72 brain tissues. SLITRK2 encodes for a post-synaptic adhesion protein. We further show that synaptic vesicle glycoprotein 2 and synaptophysin, two synaptic vesicle proteins, were decreased in frontal cortex of C9orf72 patients carrying the minor allele. Upregulation of SLITRK2 might be associated with synaptic dysfunctions and drives adverse effects in C9orf72 patients that could be modulated in those carrying the protective allele. How the modulation of SLITRK2 expression affects synaptic functions and influences the disease onset of dementia in C9orf72 carriers will require further investigations. In summary, this study describes an original approach to detect modifier genes in rare diseases and reinforces rising links between C9orf72 and synaptic dysfunctions that might directly influence the occurrence of first symptoms.
Published: 2021

35. FHL1 is a major host factor for chikungunya virus infection

Author: Cécile Doyen, Thérèse Couderc, Alexis Brugier, R. Juntas-Morales, Philippe Roingeard, Rabah Ben Yaou, Julien Burlaud-Gaillard, Etienne Simon-Loriere, Mohamed Lamine Hafirassou, Sophia Rafasse, Vasiliya Kril, Pierre-Olivier Vidalain, Laura Pezzi, Gisèle Bonne, Lucie Gueneau, Xavier de Lamballerie, Marc Lecuit, Laurent Meertens, Anne Bertrand-Legout, Beate M. Kümmerer, Ali Amara, Lucie Bonnet-Madin, Thibaud Goupil, Constance Delaugerre, Athena Labeau, Monsef Benkirane, Génomes, biologie cellulaire et thérapeutiques (GenCellDi (UMR_S_944)), Collège de France (CdF (institution))-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Virology [Bonn, Germany], University of Bonn Medical Centre, Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses, Institut Pasteur [Paris] (IP), Morphogénèse et antigénicité du VIH et du virus des Hépatites (MAVIVH - U1259 Inserm - CHRU Tours ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Equipe Chimie et Biologie, Modélisation et Immunologie pour la Thérapie (CBMIT), Université Paris Descartes - Paris 5 (UPD5)-Université Paris Descartes - Paris 5 (UPD5), Génomique virale et vaccination, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Laboratoire de Virologie [CHU Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de maladies infectieuses et tropicales [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Service des Maladies infectieuses et tropicales [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This study received funding from the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (ANR-10-LABX-62-IBEID), the ‘Investissements d’Avenir’ program (ANR-10-IHUB-0002, ANR-15-CE15-00029 ZIKAHOST and the INCEPTION program ANR-16-CONV-0005), Institut Pasteur, Inserm and European Research Council. Viruses were provided by the Europe and Virus Archive, which has received funding from the EU Horizon 2020 research and innovation program under grant agreement 653316. The authors thank the EA7310, Laboratoire de Virologie, Université de Corse-Inserm for funding the doctoral position of L.P., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-17-CE15-0029,ZIKAHOST,LES FACTEURS DE L'HÔTE ASSOCIÉS À LA NEUROPATHOGÉNICITÉ DU VIRUS ZIKA(2017), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Institut National de la Santé et de la Recherche Médicale (INSERM)-Collège de France (CdF (institution))-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris], Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Myologie, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), BUISINE, Soline, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, LES FACTEURS DE L'HÔTE ASSOCIÉS À LA NEUROPATHOGÉNICITÉ DU VIRUS ZIKA - - ZIKAHOST2017 - ANR-17-CE15-0029 - AAPG2017 - VALID, and Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs - - INCEPTION2016 - ANR-16-CONV-0005 - CONV - VALID
Subjects: Male, Permissiveness, viruses, Viral pathogenesis, Muscle Proteins, Host-Derived Cellular Factors, Alphavirus, Viral Nonstructural Proteins, Virus Replication, medicine.disease_cause, Virus, Myoblasts, Mice, 03 medical and health sciences, medicine, Animals, Humans, O'nyong-nyong Virus, Chikungunya, Cells, Cultured, 030304 developmental biology, Host factor, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, 0303 health sciences, Multidisciplinary, biology, 030306 microbiology, Intracellular Signaling Peptides and Proteins, virus diseases, Fibroblasts, LIM Domain Proteins, biology.organism_classification, Virology, FHL1, 3. Good health, HEK293 Cells, Viral replication, Host-Pathogen Interactions, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Chikungunya Fever, RNA, Viral, Female, Chikungunya virus, Protein Binding
Abstract: Chikungunya virus (CHIKV) is a re-emerging alphavirus that is transmitted to humans by mosquito bites and causes musculoskeletal and joint pain1,2. Despite intensive investigations, the human cellular factors that are critical for CHIKV infection remain unknown, hampering the understanding of viral pathogenesis and the development of anti-CHIKV therapies. Here we identified the four-and-a-half LIM domain protein 1 (FHL1)3 as a host factor that is required for CHIKV permissiveness and pathogenesis in humans and mice. Ablation of FHL1 expression results in the inhibition of infection by several CHIKV strains and o’nyong-nyong virus, but not by other alphaviruses and flaviviruses. Conversely, expression of FHL1 promotes CHIKV infection in cells that do not normally express it. FHL1 interacts directly with the hypervariable domain of the nsP3 protein of CHIKV and is essential for the replication of viral RNA. FHL1 is highly expressed in CHIKV-target cells and is particularly abundant in muscles3,4. Dermal fibroblasts and muscle cells derived from patients with Emery–Dreifuss muscular dystrophy that lack functional FHL15 are resistant to CHIKV infection. Furthermore, CHIKV infection is undetectable in Fhl1-knockout mice. Overall, this study shows that FHL1 is a key factor expressed by the host that enables CHIKV infection and identifies the interaction between nsP3 and FHL1 as a promising target for the development of anti-CHIKV therapies. FHL1 is a key factor expressed by humans and mice that is required for chikungunya virus infection and is therefore a promising target for the development of therapies against chikungunya virus.
Published: 2019

36. Social support and sleep quality in older benzodiazepine users

Author: Diana Cruz-Santiago, Caroline Desrosiers, Vanessa Léveillé, Arnaud Allary, Marie-Christine Payette, Catherine Bernard, Josie-Anne Bertrand, Marie-Michelle Boudreau, Virginie Proulx-Tremblay, Marie-Hélène Gagné, Sébastien Grenier, and Fethia Benyebdri
Subjects: medicine.medical_specialty, medicine.drug_class, Poor quality, Benzodiazepines, 03 medical and health sciences, Social support, 0302 clinical medicine, Sleep Initiation and Maintenance Disorders, Sleep difficulties, medicine, Humans, Psychiatry, Aged, Aged, 80 and over, Benzodiazepine, 030214 geriatrics, Sleep quality, business.industry, Social Support, Anxiety Disorders, Sleep in non-human animals, 3. Good health, Psychiatry and Mental health, Geriatrics and Gerontology, Pshychiatric Mental Health, Sleep, business, Gerontology, 030217 neurology & neurosurgery
Abstract: Objective: Benzodiazepines (BZD) are often prescribed to address sleep difficulties but many BZD users report a poor quality of sleep. Although social support was found to be associated with qualit...
Published: 2019

37. Devenir des gammapathies monoclonales sous inhibiteurs de JAK (étude JAKPIC)

Author: Marie-Elise Truchetet, P. Meunier, D. Shima, T. Schaeverbeke, D. Faganello, Marie Kostine, Fabienne Coury, Eric Toussirot, Anne Bertrand, and Christophe Richez
Subjects: Rheumatology
Published: 2021

38. A new milestone for the study of variation in Montréal French: The Hochelaga-Maisonneuve sociolinguistic survey

Author: Anne Bertrand, Mireille Tremblay, Elizabeth Michel, and Hélène Blondeau
Subjects: History, media_common.quotation_subject, Variation, français québécois, Change, Corpus, Temps réel, Real Time, Presentation, Transcription (linguistics), Milestone (project management), Selection (linguistics), Composition (language), Temps apparent, General Environmental Science, media_common, French, language.human_language, Linguistics, Stratified sampling, Changement, Variation (linguistics), Apparent Time, language, General Earth and Planetary Sciences, Québec French
Abstract: This article introduces the 2012 Montréal FRAN-HOMA corpus, collected in the Francophone neighborhood of Hochelaga-Maisonneuve, and how it relates to the heritage corpora of Montréal French collected since the 1970s. We discuss the methodological choices made regarding the composition of this corpus including the historical and demo-linguistic information that led to the selection of the Hochelaga-Maisonneuve neighborhood for fieldwork. A presentation of the socially stratified sample and criteria for participant selection is followed by a discussion on data collection and the sociolinguistic interview. After a brief review of the transcription protocol and the advantages of audio-aligned transcription, we provide two illustrations of the revival of research on linguistic variation made possible by this new corpus. Cet article présente le corpus FRAN-HOMA de Montréal 2012 recueilli dans le quartier francophone d’Hochelaga-Maisonneuve, et son rapport avec les corpus patrimoniaux de français montréalais recueillis depuis les années 1970. Nous discutons des choix méthodologiques effectués concernant la composition de ce corpus, y compris les informations historiques et démo-linguistiques qui ont conduit à la sélection d’Hochelaga-Maisonneuve comme site pour le travail de terrain. Une présentation de l’échantillon socialement stratifié et des critères de sélection des participants est suivie d’une discussion sur la collecte des données et l’entretien sociolinguistique. Après un bref exposé sur le protocole de transcription et les avantages de la transcription audio-alignée, nous fournissons deux illustrations de la relance de la recherche sur la variation linguistique rendue possible par ce nouveau corpus.
Published: 2021

39. Reproducible evaluation of diffusion MRI features for automatic classification of patients with Alzheimer's disease

Author: Jorge Samper-González, Junhao Wen, Alexandre Routier, Stanley Durrleman, Simona Bottani, Sabrina Fontanella, Anne Bertrand, Olivier Colliot, Ninon Burgos, Thomas Jacquemont, Stéphane Epelbaum, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), The research leading to these results has received funding from the program 'Investissements d’avenir' ANR-10-IAIHU-06 (Agence Nationale de la Recherche-10-IA Institut Hospitalo-Universitaire-6) ANR-11-IDEX-004 (Agence Nationale de la Recherche-11-Initiative d’Excellence-004, project LearnPETMR number SU-16-R-EMR-16), from the European Union H2020 program (project EuroPOND, grant number 666992, project HBP SGA1 grant number 720270), from the joint NSF/NIH/ANR program 'Collaborative Research in Computational Neuroscience' (project HIPLAY7, grant number ANR-16-NEUC-0001-01), from Agence Nationale de la Recherche (project PREVDEMALS, grant number ANR-14-CE15-0016-07),from the European Research Council (to Dr Durrleman project LEASP, grant number 678304),from the Abeona Foundation (project Brain@Scale), and from the French government under management of Agence Nationale de la Recherche as part of the 'Investissements d’avenir' program, reference ANR-19-P3IA-0001 (PRAIRIE 3IA Institute).J.W. receives financial support from China Scholarship Council (CSC). O.C. is supported by a 'Contrat d’Interface Local' from Assistance Publique-Hôpitaux de Paris (AP-HP). N.B. receives funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no. PCOFUND-GA-2013-609102, through the PRESTIGE programme coordinated by Campus France., ANR-19-P3IA-0001,PRAIRIE,PaRis Artificial Intelligence Research InstitutE(2019), Colliot, Olivier, PaRis Artificial Intelligence Research InstitutE - - PRAIRIE2019 - ANR-19-P3IA-0001 - P3IA - VALID, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Sorbonne Université (SU)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: FOS: Computer and information sciences, Male, Computer Science - Machine Learning, Open-source, Computer science, Diffusion magnetic resonance imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Quantitative Biology - Quantitative Methods, Machine Learning (cs.LG), [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], 0302 clinical medicine, Statistics - Machine Learning, Preprocessor, Quantitative Methods (q-bio.QM), Aged, 80 and over, Small data, General Neuroscience, Image and Video Processing (eess.IV), 05 social sciences, Brain, Alzheimer's disease, Classification, Reproducibility, 3. Good health, Feature (computer vision), DTI, Female, Smoothing, Information Systems, [INFO.INFO-AI] Computer Science [cs]/Artificial Intelligence [cs.AI], Feature extraction, Machine Learning (stat.ML), Feature selection, 050105 experimental psychology, 03 medical and health sciences, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], Alzheimer Disease, Image Interpretation, Computer-Assisted, Fractional anisotropy, Machine learning, FOS: Electrical engineering, electronic engineering, information engineering, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, 0501 psychology and cognitive sciences, Aged, business.industry, Pattern recognition, [INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG], Electrical Engineering and Systems Science - Image and Video Processing, FOS: Biological sciences, Artificial intelligence, business, 030217 neurology & neurosurgery, Software, Diffusion MRI
Abstract: Diffusion MRI is the modality of choice to study alterations of white matter. In past years, various works have used diffusion MRI for automatic classification of AD. However, classification performance obtained with different approaches is difficult to compare and these studies are also difficult to reproduce. In the present paper, we first extend a previously proposed framework to diffusion MRI data for AD classification. Specifically, we add: conversion of diffusion MRI ADNI data into the BIDS standard and pipelines for diffusion MRI preprocessing and feature extraction. We then apply the framework to compare different components. First, FS has a positive impact on classification results: highest balanced accuracy (BA) improved from 0.76 to 0.82 for task CN vs AD. Secondly, voxel-wise features generally gives better performance than regional features. Fractional anisotropy (FA) and mean diffusivity (MD) provided comparable results for voxel-wise features. Moreover, we observe that the poor performance obtained in tasks involving MCI were potentially caused by the small data samples, rather than by the data imbalance. Furthermore, no extensive classification difference exists for different degree of smoothing and registration methods. Besides, we demonstrate that using non-nested validation of FS leads to unreliable and over-optimistic results: 0.05 up to 0.40 relative increase in BA. Lastly, with proper FR and FS, the performance of diffusion MRI features is comparable to that of T1w MRI. All the code of the framework and the experiments are publicly available: general-purpose tools have been integrated into the Clinica software package (www.clinica.run) and the paper-specific code is available at: https://github.com/aramis-lab/AD-ML., 51 pages, 5 figure and 6 tables
Published: 2021

40. « A toi appartient le regard et (…) la liaison infinie entre les choses » (sous la dir. de Christine Barthe)

Author: Anne Bertrand
Subjects: General Engineering
Published: 2020

41. Markus Lüpertz, Narcisse et Echo. Discours, essais et poèmes 1961-2019

Author: Anne Bertrand
Subjects: General Engineering
Abstract: En 2007 paraissait a Munster un recueil des ecrits du peintre et sculpteur allemand Markus Lupertz (ne en 1941 a Reichenberg), rediges de 1961 a 2004, reunis par l’historien de l’art et directeur de musee Siegfried Gohr, sous le meme titre que cette volumineuse anthologie francaise (603 p.), qui le continue jusqu’en 2019. Elle s’ouvre sur une preface d’Eric Darragon, egalement specialiste de Georg Baselitz, contemporain de Lupertz. Ce dernier a fait l’objet d’une retrospective au musee d’Art ...
Published: 2020

42. Vincent Bioulès, Journal (1972-2018) : « Dieu, les autres, les femmes, la peinture, la vie enfin… »

Author: Anne Bertrand
Subjects: General Engineering
Published: 2020

43. Copies, écarts et variations dans la création contemporaine (sous la dir. de Céline Cadaureille, Anne Favier)

Author: Anne Bertrand
Subjects: General Engineering
Published: 2020

44. Psychological pain and depression: it's hard to speak when it hurts

Author: Sébastien Guillaume, Josie-Anne Bertrand, Stéphane Richard-Devantoy, Aurélie Cazals, Emilie Olié, Déborah Ducasse, Séverine Béziat, Kyle T. Greenway, Philippe Courtet, Isabelle Jaussent, Douglas Mental Health University Institute [Montréal], McGill University = Université McGill [Montréal, Canada], CISSS des Laurentides, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Adult, Male, medicine.medical_specialty, Pain, Neuropsychological Tests, 03 medical and health sciences, 0302 clinical medicine, Cognition, Phonetics, medicine, Verbal fluency test, Humans, Psychiatry, Depression (differential diagnoses), Depressive Disorder, Major, Depression, Verbal Behavior, verbal fluency, Neuropsychology, Psychological pain, Middle Aged, 030227 psychiatry, Semantics, Psychiatry and Mental health, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Female, Psychology, 030217 neurology & neurosurgery
Abstract: International audience; Objective: To investigate the neuropsychological features of depressed patients reporting high level of psychological pain.Methods: Sixty-two inpatients were included and divided into two groups according to the level of psychological pain assessed by a Likert scale. Cognitive abilities were assessed using the Trail Making Test, the Stroop test, and Verbal Fluency Test (semantic and phonemic verbal fluency). Univariate and multivariate analyses were performed to determine neuropsychological factors associated with a high level of psychological pain.Results: The median level of psychological pain was 8/10. High level of psychological pain was associated with poor phonemic verbal fluency performance in men (p = 0.009), but not in women, even after controlling for confounding factors (age, level of depression, anxiety). Groups did not differ on the Trail Making Test, the Stroop test, or the semantic verbal fluency measure.Conclusion: Psychological pain is a specific clinical entity that should be considered to be more significant than just a symptom of depression. High level of psychological pain appears to be associated with a deficit of phonemic verbal fluency in depressed men. This finding could help to target psychotherapeutic treatments and improve screening.Key pointsPatients with high psychological pain do not differ on the Trail Making Test, the Stroop Test or the Sematic Verbal Fluency Measure to patients with low psychological painHigh psychological pain is associated with a deficit in phonemic verbal fluency in depressed menFuture research should aim to clarify gender differences in psychological pain in participants with and without major depressive disorder, as well as explore the complex relationship between cognition and the different forms of pain (psychological, physical and psychosomatic).
Published: 2020

45. FHL1 is a key player of chikungunya virus tropism and pathogenesis

Author: Meertens, Laurent, primary, Hafirassou, Mohamed Lamine, additional, Couderc, Thérèse, additional, Bonnet-Madin, Lucie, additional, Kril, Vasiliya, additional, Kümmerer, Beate M., additional, Labeau, Athena, additional, Brugier, Alexis, additional, Simon-Loriere, Etienne, additional, Burlaud-Gaillard, Julien, additional, Doyen, Cécile, additional, Pezzi, Laura, additional, Goupil, Thibaud, additional, Rafasse, Sophia, additional, Vidalain, Pierre-Olivier, additional, Legout, Anne Bertrand, additional, Gueneau, Lucie, additional, Juntas-Morales, Raul, additional, Yaou, Rabah Ben, additional, Bonne, Gisèle, additional, de Lamballerie, Xavier, additional, Benkirane, Monsef, additional, Roingeard, Philippe, additional, Delaugerre, Constance, additional, Lecuit, Marc, additional, and Amara, Ali, additional
Published: 2021
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46. Are endocasts reliable proxies for brains? A 3D quantitative comparison of the extant human brain and endocast

Author: Jean Dumoncel, Stanley Durrleman, Edwin John De Jager, Anne Bertrand, Farhana Ebrahim Suleman, Zarina I. Lockhat, Gérard Subsol, Amélie Beaudet, Anna Catherina Oettle, Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Image & Interaction (ICAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Pretoria [South Africa], University of Cambridge [UK] (CAM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Gestionnaire, HAL Sorbonne Université 5, Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Male, Histology, Brain shape, [SDV]Life Sciences [q-bio], Surface‐based comparison, Neuroimaging, Biology, Paleoneurology, 03 medical and health sciences, Sulci, 0302 clinical medicine, Imaging, Three-Dimensional, Extant taxon, medicine, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Original Paper, Fossil Record, Crania, Brain, Cell Biology, Human brain, Anatomy, biology.organism_classification, Original Papers, [SDV] Life Sciences [q-bio], 030104 developmental biology, medicine.anatomical_structure, Female, Automatic segmentation, 030217 neurology & neurosurgery, Endocast, Developmental Biology, Shape analysis (digital geometry)
Abstract: Endocasts (i.e., replicas of the inner surface of the bony braincase) constitute a critical proxy for qualifying and quantifying variations in brain shape and organization in extinct taxa. In the absence of brain tissues preserved in the fossil record, endocasts provide the only direct evidence of brain evolution. However, debates on whether or not information inferred from the study of endocasts reflects brain shape and organization have polarized discussions in paleoneurology since the earliest descriptions of cerebral imprints in fossil hominin crania. By means of imaging techniques (i.e., MRIs and CT scans) and 3D modelling methods (i.e., surface‐based comparisons), we collected consistent morphological (i.e., shape) and structural (i.e., sulci) information on the variation patterns between the brain and the endocast based on a sample of extant human individuals (N = 5) from the 3D clinical image database of the Steve Biko Academic Hospital in Pretoria (South Africa) and the Hôpitaux Universitaires Pitié Salpêtrière in Paris (France). Surfaces of the brain and endocast of the same individual were segmented from the 3D MRIs and CT images, respectively. Sulcal imprints were automatically detected. We performed a deformation‐based shape analysis to compare both the shape and the sulcal pattern of the brain and the endocast. We demonstrated that there is close correspondence in terms of morphology and organization between the brain and the corresponding endocast with the exception of the superior region. By comparatively quantifying the shape and organization of the brain and endocast, this work represents an important reference for paleoneurological studies., Is the endocast a reliable proxy for reconstructing the brain of fossil specimens? By quantitatively comparing extant human brains and endocasts using MRIs and CT‐scans, here we address this fundamental question and support the significance of fossil endocasts in paleoneurological studies.
Published: 2020

47. Mitochondria in human acute myeloid leukemia cell lines have ultrastructural alterations linked to deregulation of their respiratory profiles

Author: Sylvie Tondeur, Caroline Lo Presti, Karin Pernet-Gallay, Anne Mc Leer, Sandrine Blanchet, Julie Mondet, Pascal Mossuz, Simon Chevalier, and Anne Bertrand
Subjects: 0301 basic medicine, Cancer Research, Mitochondrial disease, Cell, HL-60 Cells, Biology, Mitochondrion, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Mitophagy, Genetics, medicine, Humans, Molecular Biology, Endoplasmic reticulum membrane, Endoplasmic reticulum, Myeloid leukemia, Cell Biology, Hematology, medicine.disease, Mitochondria, Neoplasm Proteins, Cell biology, Repressor Proteins, Leukemia, Myeloid, Acute, 030104 developmental biology, medicine.anatomical_structure, Apoptosis, 030220 oncology & carcinogenesis, Mutation, K562 Cells
Abstract: Mitochondria not only are essential for cell metabolism and energy supply but are also engaged in calcium homeostasis and reactive oxygen species generation and play a key role in apoptosis. As a consequence, functional mitochondrial disorders are involved in many human cancers including acute myeloid leukemia (AML). However, very few data are available on the deregulation of their number and/or shape in leukemic cells, despite the evident link between ultrastructure and function. In this context, we analyzed the ultrastructural mitochondrial parameters (number per cell, mitochondria area, number of cristae/mitochondria, cristal thickness) in five leukemia cell lines (HEL, HL60, K562, KG1, and OCI-AML3) together with the functional assay of their respiratory profile. First, we describe significant differences in basal respiration, maximal respiration, ATP production, and spare respiratory capacity between our cell lines, confirming the various respiratory profiles among leukemia subtypes. Second, we highlight that these variations are obviously associated with significant interleukemia heterogeneity of the number and/or shape of mitochondria. For instance, KG1, characterized by the smallest number of mitochondria together with reduced cristal diameter, had a particularly deficient respiratory profile. In comparison, the HEL and K562 cell lines, both with high respiratory profiles, harbored the largest number of mitochondria/cells with high cristal diameters. Moreover, we report that K562, carrying the ASXL1 mutation, presents significant mitochondria-endoplasmic reticulum deficiency reflected by decreases in the numbers of matrix granules and mitochondria-associated endoplasmic reticulum membrane (MAM) and mitochondrial-derived vesicle (MDV) precursors, which are implicated in the regulatory pathways of cell mortality via the processes of mitophagy and calcium homeostasis. Contrarily, HL60 carried high levels of matrix granules and MAMs and had a higher sensitivity to drugs targeting mitochondria (rotenone/antimycin). We confirm the implication of ASXL1 mutation in this mitochondria dysregulation through the study of transcript expression (from 415 patients with public data) involved in three mitochondrial pathways: (1) endoplasmic reticulum-mitochondria contacts (MAMs), (2) matrix granule homeostasis, and (3) MDV precursor production. Our study offers new and original data on mitochondria structural alterations linked to deregulation of respiration profiles in AMLs and some genetic characteristics, suggesting that modifications of mitochondrial shape and/or number in leukemic cells participate in chemoresistance and could be a targeted mechanism to regulate their proliferative potential.
Published: 2020

48. Eric Rondepierre, Double feinte. Territoire des fictions secondes

Author: Anne Bertrand
Subjects: General Engineering
Abstract: Artiste mais aussi ecrivain, Eric Rondepierre a largement travaille, depuis le debut des annees 1990, l’idee de fiction qui traverse ses photographies, livres et videos. Il consacre un essai a la notion de « fiction seconde », ainsi definie : « C’est ce degre de la feintise […], et plus particulierement ces courts moments, dans les fictions, ou des personnages, au lieu d’effectuer une action, prennent la decision de la simuler, de la mimer. […]. Exemples : boire un verre sans verre, tirer au ...
Published: 2020

49. Nicolas Bouvier, Du coin de l’œil : écrits sur la photographie

Author: Anne Bertrand
Subjects: General Engineering
Abstract: Nicolas Bouvier (1929-1998) disait : « je fais des photographies sans etre photographe, et j’ecris de temps en temps sans etre veritablement ecrivain. Je crois que si je devais me prevaloir d’une specialite j’opterais pour celle de voyageur. Etre l’œil ou l’esprit qui se promene, observe, compare et ensuite relate, une sorte de temoin ». L’Usage du monde (1963), et ses livres suivants, ont etabli l’auteur suisse comme un des plus curieux, fins, genereux ecrivains-voyageurs. Alexandre Chollier...
Published: 2020

50. Donald Judd Interviews

Author: Anne Bertrand
Subjects: General Engineering
Abstract: En 2016 paraissait le volume Donald Judd Writings, 1056 pages sous couverture rouge cadmium, aujourd’hui rejoint par son jumeau, 1023 pages sous couverture marine, egalement publie, avec la galerie David Zwirner a New York, par la Judd Foundation. Concue en 1977 par l’artiste americain Donald Judd (1928-1994), creee en 1996 et dirigee par ses enfants Flavin et Rainer Judd, elle a pour mission, a Marfa, Texas, comme au 101, Spring Street a New York, de preserver les lieux ou il vecut et travai...
Published: 2020

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