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1. Ariel: Enabling planetary science across light-years

Author

Giovanna Tinetti, Paul Eccleston, Carole Haswell, Pierre-Olivier Lagage, Jérémy Leconte, Theresa Lüftinger, Giusi Micela, Michel Min, Göran Pilbratt, Ludovic Puig, Mark Swain, Leonardo Testi, Diego Turrini, Bart Vandenbussche, Maria Rosa Zapatero Osorio, Anna Aret, Jean-Philippe Beaulieu, Buchhave, Lars A., Martin Ferus, Matt Griffin, Manuel Guedel, Paul Hartogh, Pedro Machado, Giuseppe Malaguti, Enric Pallé, Mirek Rataj, Tom Ray, Ignasi Ribas, Robert Szabó, Jonathan Tan, Stephanie Werner, Francesco Ratti, Carsten Scharmberg, Jean-Christophe Salvignol, Nathalie Boudin, Jean-Philippe Halain, Martin Haag, Pierre-Elie Crouzet, Ralf Kohley, Kate Symonds, Florian Renk, Andrew Caldwell, Manuel Abreu, Gustavo Alonso, Jerome Amiaux, Michel Berthé, Georgia Bishop, Neil Bowles, Manuel Carmona, Deirdre Coffey, Josep Colomé, Martin Crook, Lucile Désjonqueres, Díaz, José J., Rachel Drummond, Mauro Focardi, Gómez, Jose M., Warren Holmes, Matthijs Krijger, Zsolt Kovacs, Tom Hunt, Richardo Machado, Gianluca Morgante, Marc Ollivier, Roland Ottensamer, Emanuele Pace, Teresa Pagano, Enzo Pascale, Chris Pearson, Søren Møller Pedersen, Moshe Pniel, Stéphane Roose, Giorgio Savini, Richard Stamper, Peter Szirovicza, Janos Szoke, Ian Tosh, Francesc Vilardell, Joanna Barstow, Luca Borsato, Sarah Casewell, Quentin Changeat, Benjamin Charnay, Svatopluk Civiš, Vincent Coudé du Foresto, Athena Coustenis, Nicolas Cowan, Camilla Danielski, Olivier Demangeon, Pierre Drossart, Edwards, Billy N., Gabriella Gilli, Therese Encrenaz, Csaba Kiss, Anastasia Kokori, Masahiro Ikoma, Juan Carlos Morales, Joao Mendonca, Andrea Moneti, Lorenzo Mugnai, Antonio García Muñoz, Ravit Helled, Mihkel Kama, Yamila Miguel, Nikos Nikolaou, Isabella Pagano, Olja Panic, Miriam Rengel, Hans Rickman, Marco Rocchetto, Subhajit Sarkar, Franck Selsis, Jonathan Tennyson, Angelos Tsiaras, Olivia Venot, Krisztián Vida, Waldmann, Ingo P., Sergey Yurchenko, Gyula Szabó, Rob Zellem, Ahmed Al-Refaie, Javier Perez Alvarez, Lara Anisman, Axel Arhancet, Jaume Ateca, Robin Baeyens, Barnes, John R., Taylor Bell, Serena Benatti, Katia Biazzo, Maria Błęcka, Aldo Stefano Bonomo, José Bosch, Diego Bossini, Jeremy Bourgalais, Daniele Brienza, Anna Brucalassi, Giovanni Bruno, Hamish Caines, Simon Calcutt, Tiago Campante, Rodolfo Canestrari, Nick Cann, Giada Casali, Albert Casas, Giuseppe Cassone, Christophe Cara, Ludmila Carone, Nathalie Carrasco, Paolo Chioetto, Fausto Cortecchia, Markus Czupalla, Chubb, Katy L., Angela Ciaravella, Antonio Claret, Riccardo Claudi, Claudio Codella, Maya Garcia Comas, Gianluca Cracchiolo, Patricio Cubillos, Vania Da Peppo, Leen Decin, Clemence Dejabrun, Elisa Delgado-Mena, Anna Di Giorgio, Emiliano Diolaiti, Caroline Dorn, Vanessa Doublier, Eric Doumayrou, Georgina Dransfield, Luc Dumaye, Emma Dunford, Antonio Jimenez Escobar, Vincent Van Eylen, Maria Farina, Davide Fedele, Alejandro Fernández, Benjamin Fleury, Sergio Fonte, Jean Fontignie, Luca Fossati, Bernd Funke, Camille Galy, Zoltán Garai, Andrés García, Alberto García-Rigo, Antonio Garufi, Giuseppe Germano Sacco, Paolo Giacobbe, Alejandro Gómez, Arturo Gonzalez, Francisco Gonzalez-Galindo, Davide Grassi, Caitlin Griffith, Mario Giuseppe Guarcello, Audrey Goujon, Amélie Gressier, Aleksandra Grzegorczyk, Tristan Guillot, Gloria Guilluy, Peter Hargrave, Marie-Laure Hellin, Enrique Herrero, Matt Hills, Benoit Horeau, Yuichi Ito, Niels Christian Jessen, Petr Kabath, Szilárd Kálmán, Yui Kawashima, Tadahiro Kimura, Antonín Knížek, Laura Kreidberg, Ronald Kruid, Kruijssen, Diederik J. M., Petr Kubelík, Luisa Lara, Sebastien Lebonnois, David Lee, Maxence Lefevre, Tim Lichtenberg, Daniele Locci, Matteo Lombini, Alejandro Sanchez Lopez, Andrea Lorenzani, Ryan MacDonald, Laura Magrini, Jesus Maldonado, Emmanuel Marcq, Alessandra Migliorini, Darius Modirrousta-Galian, Karan Molaverdikhani, Sergio Molinari, Paul Mollière, Vincent Moreau, Giuseppe Morello, Gilles Morinaud, Mario Morvan, Moses, Julianne I., Salima Mouzali, Nariman Nakhjiri, Luca Naponiello, Norio Narita, Valerio Nascimbeni, Athanasia Nikolaou, Vladimiro Noce, Fabrizio Oliva, Pietro Palladino, Andreas Papageorgiou, Vivien Parmentier, Giovanni Peres, Javier Pérez, Santiago Perez-Hoyos, Manuel Perger, Cesare Cecchi Pestellini, Antonino Petralia, Anne Philippon, Arianna Piccialli, Marco Pignatari, Giampaolo Piotto, Linda Podio, Gianluca Polenta, Giampaolo Preti, Theodor Pribulla, Manuel Lopez Puertas, Monica Rainer, Jean-Michel Reess, Paul Rimmer, Séverine Robert, Albert Rosich, Loic Rossi, Duncan Rust, Ayman Saleh, Nicoletta Sanna, Eugenio Schisano, Laura Schreiber, Victor Schwartz, Antonio Scippa, Bálint Seli, Sho Shibata, Caroline Simpson, Oliver Shorttle, Skaf, N., Konrad Skup, Mateusz Sobiecki, Sergio Sousa, Alessandro Sozzetti, Judit Šponer, Lukas Steiger, Paolo Tanga, Paul Tackley, Jake Taylor, Matthias Tecza, Luca Terenzi, Pascal Tremblin, Andrea Tozzi, Amaury Triaud, Loïc Trompet, Shang-Min Tsai, Maria Tsantaki, Diana Valencia, Ann Carine Vandaele, Mathieu Van der Swaelmen, Adibekyan Vardan, Gautam Vasisht, Allona Vazan, Ciro Del Vecchio, Dave Waltham, Piotr Wawer, Thomas Widemann, Paulina Wolkenberg, Gordon Hou Yip, Yuk Yung, Mantas Zilinskas, Tiziano Zingales, Paola Zuppella, University College of London [London] (UCL), Space Science and Technology Department [Didcot] (RAL Space), STFC Rutherford Appleton Laboratory (RAL), Science and Technology Facilities Council (STFC)-Science and Technology Facilities Council (STFC), Université de Bordeaux (UB), Agence Spatiale Européenne = European Space Agency (ESA), SRON Netherlands Institute for Space Research (SRON), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Istituto Nazionale di Astrofisica (INAF), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Bologna (OABO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique (BIRA-IASB), European Space Agency, Agence Spatiale Européenne (ESA), European Space Agency (ESA), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Giovanna Tinetti, Paul Eccleston, Carole Haswell, Pierre-Olivier Lagage, Jérémy Leconte, Theresa Lüftinger, Giusi Micela, Michel Min, Göran Pilbratt, Ludovic Puig, Mark Swain, Leonardo Testi, Diego Turrini, Bart Vandenbussche, Maria Rosa Zapatero Osorio, Anna Aret, Jean-Philippe Beaulieu, Lars Buchhave, Martin Feru, Matt Griffin, Manuel Guedel, Paul Hartogh, Pedro Machado, Giuseppe Malaguti, Enric Pallé, Mirek Rataj, Tom Ray, Ignasi Riba, Robert Szabó, Jonathan Tan, Stephanie Werner, Francesco Ratti, Carsten Scharmberg, Jean-Christophe Salvignol, Nathalie Boudin, Jean-Philippe Halain, Martin Haag, Pierre-Elie Crouzet, Ralf Kohley, Kate Symond, Florian Renk, Andrew Caldwell, Manuel Abreu, Gustavo Alonso, Jerome Amiaux, Michel Berthé, Georgia Bishop, Neil Bowle, Manuel Carmona, Deirdre Coffey, Josep Colomé, Martin Crook, Lucile Désjonquere, José J. Díaz, Rachel Drummond, Mauro Focardi, Jose M. Gómez, Warren Holme, Matthijs Krijger, Zsolt Kovac, Tom Hunt, Richardo Machado, Gianluca Morgante, Marc Ollivier, Roland Ottensamer, Emanuele Pace, Teresa Pagano, Enzo Pascale, Chris Pearson, Søren Møller Pedersen, Moshe Pniel, Stéphane Roose, Giorgio Savini, Richard Stamper, Peter Szirovicza, Janos Szoke, Ian Tosh, Francesc Vilardell, Joanna Barstow, Luca Borsato, Sarah Casewell, Quentin Changeat, Benjamin Charnay, Svatopluk Civiš, Vincent Coudé du Foresto, Athena Cousteni, Nicolas Cowan, Camilla Danielski, Olivier Demangeon, Pierre Drossart, Billy N. Edward, Gabriella Gilli, Therese Encrenaz, Csaba Ki, Anastasia Kokori, Masahiro Ikoma, Juan Carlos Morale, João Mendonça, Andrea Moneti, Lorenzo Mugnai, Antonio García Muñoz, Ravit Helled, Mihkel Kama, Yamila Miguel, Nikos Nikolaou, Isabella Pagano, Olja Panic, Miriam Rengel, Hans Rickman, Marco Rocchetto, Subhajit Sarkar, Franck Selsi, Jonathan Tennyson, Angelos Tsiara, Olivia Venot, Krisztián Vida, Ingo P. Waldmann, Sergey Yurchenko, Gyula Szabó, Rob Zellem, Ahmed Al-Refaie, Javier Perez Alvarez, Lara Anisman, Axel Arhancet, Jaume Ateca, Robin Baeyen, John R. Barne, Taylor Bell, Serena Benatti, Katia Biazzo, Maria Błęcka, Aldo Stefano Bonomo, José Bosch, Diego Bossini, Jeremy Bourgalai, Daniele Brienza, Anna Brucalassi, Giovanni Bruno, Hamish Caine, Simon Calcutt, Tiago Campante, Rodolfo Canestrari, Nick Cann, Giada Casali, Albert Casa, Giuseppe Cassone, Christophe Cara, Ludmila Carone, Nathalie Carrasco, Paolo Chioetto, Fausto Cortecchia, Markus Czupalla, Katy L. Chubb, Angela Ciaravella, Antonio Claret, Riccardo Claudi, Claudio Codella, Maya Garcia Coma, Gianluca Cracchiolo, Patricio Cubillo, Vania Da Peppo, Leen Decin, Clemence Dejabrun, Elisa Delgado-Mena, Anna Di Giorgio, Emiliano Diolaiti, Caroline Dorn, Vanessa Doublier, Eric Doumayrou, Georgina Dransfield, Luc Dumaye, Emma Dunford, Antonio Jimenez Escobar, Vincent Van Eylen, Maria Farina, Davide Fedele, Alejandro Fernández, Benjamin Fleury, Sergio Fonte, Jean Fontignie, Luca Fossati, Bernd Funke, Camille Galy, Zoltán Garai, Andrés García, Alberto García-Rigo, Antonio Garufi, Giuseppe Germano Sacco, Paolo Giacobbe, Alejandro Gómez, Arturo Gonzalez, Francisco Gonzalez-Galindo, Davide Grassi, Caitlin Griffith, Mario Giuseppe Guarcello, Audrey Goujon, Amélie Gressier, Aleksandra Grzegorczyk, Tristan Guillot, Gloria Guilluy, Peter Hargrave, Marie-Laure Hellin, Enrique Herrero, Matt Hill, Benoit Horeau, Yuichi Ito, Niels Christian Jessen, Petr Kabath, Szilárd Kálmán, Yui Kawashima, Tadahiro Kimura, Antonín Knížek, Laura Kreidberg, Ronald Kruid, Diederik J. M. Kruijssen, Petr Kubelík, Luisa Lara, Sebastien Lebonnoi, David Lee, Maxence Lefevre, Tim Lichtenberg, Daniele Locci, Matteo Lombini, Alejandro Sanchez Lopez, Andrea Lorenzani, Ryan MacDonald, Laura Magrini, Jesus Maldonado, Emmanuel Marcq, Alessandra Migliorini, Darius Modirrousta-Galian, Karan Molaverdikhani, Sergio Molinari, Paul Mollière, Vincent Moreau, Giuseppe Morello, Gilles Morinaud, Mario Morvan, Julianne I. Mose, Salima Mouzali, Nariman Nakhjiri, Luca Naponiello, Norio Narita, Valerio Nascimbeni, Athanasia Nikolaou, Vladimiro Noce, Fabrizio Oliva, Pietro Palladino, Andreas Papageorgiou, Vivien Parmentier, Giovanni Pere, Javier Pérez, Santiago Perez-Hoyo, Manuel Perger, Cesare Cecchi Pestellini, Antonino Petralia, Anne Philippon, Arianna Piccialli, Marco Pignatari, Giampaolo Piotto, Linda Podio, Gianluca Polenta, Giampaolo Preti, Theodor Pribulla, Manuel Lopez Puerta, Monica Rainer, Jean-Michel Ree, Paul Rimmer, Séverine Robert, Albert Rosich, Loic Rossi, Duncan Rust, Ayman Saleh, Nicoletta Sanna, Eugenio Schisano, Laura Schreiber, Victor Schwartz, Antonio Scippa, Bálint Seli, Sho Shibata, Caroline Simpson, Oliver Shorttle, N. Skaf, Konrad Skup, Mateusz Sobiecki, Sergio Sousa, Alessandro Sozzetti, Judit Šponer, Lukas Steiger, Paolo Tanga, Paul Tackley, Jake Taylor, Matthias Tecza, Luca Terenzi, Pascal Tremblin, Andrea Tozzi, Amaury Triaud, Loïc Trompet, Shang-Min Tsai, Maria Tsantaki, Diana Valencia, Ann Carine Vandaele, Mathieu Van der Swaelmen, Adibekyan Vardan, Gautam Vasisht, Allona Vazan, Ciro Del Vecchio, Dave Waltham, Piotr Wawer, Thomas Widemann, Paulina Wolkenberg, Gordon Hou Yip, Yuk Yung, Mantas Zilinska, Tiziano Zingale, Paola Zuppella, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), and Cardon, Catherine

Subjects
[SDU] Sciences of the Universe [physics], Earth and Planetary Astrophysics (astro-ph.EP), [SDU.ASTR.IM] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Settore FIS/05 - Astronomia E Astrofisica, [SDU]Sciences of the Universe [physics], [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], [SDU.ASTR.EP] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], FOS: Physical sciences, Astrophysics - Instrumentation and Methods for Astrophysic, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics - Earth and Planetary Astrophysics, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]
Abstract

Ariel, the Atmospheric Remote-sensing Infrared Exoplanet Large-survey, was adopted as the fourth medium-class mission in ESA's Cosmic Vision programme to be launched in 2029. During its 4-year mission, Ariel will study what exoplanets are made of, how they formed and how they evolve, by surveying a diverse sample of about 1000 extrasolar planets, simultaneously in visible and infrared wavelengths. It is the first mission dedicated to measuring the chemical composition and thermal structures of hundreds of transiting exoplanets, enabling planetary science far beyond the boundaries of the Solar System. The payload consists of an off-axis Cassegrain telescope (primary mirror 1100 mm x 730 mm ellipse) and two separate instruments (FGS and AIRS) covering simultaneously 0.5-7.8 micron spectral range. The satellite is best placed into an L2 orbit to maximise the thermal stability and the field of regard. The payload module is passively cooled via a series of V-Groove radiators; the detectors for the AIRS are the only items that require active cooling via an active Ne JT cooler. The Ariel payload is developed by a consortium of more than 50 institutes from 16 ESA countries, which include the UK, France, Italy, Belgium, Poland, Spain, Austria, Denmark, Ireland, Portugal, Czech Republic, Hungary, the Netherlands, Sweden, Norway, Estonia, and a NASA contribution., Comment: Ariel Definition Study Report, 147 pages. Reviewed by ESA Science Advisory Structure in November 2020. Original document available at: https://www.cosmos.esa.int/documents/1783156/3267291/Ariel_RedBook_Nov2020.pdf/

Published
2021
Full Text
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2. The EChO science case

Author

Giovanna Tinetti, Pierre Drossart, Paul Eccleston, Paul Hartogh, Kate Isaak, Martin Linder, Christophe Lovis, Giusi Micela, Marc Ollivier, Ludovic Puig, Ignasi Ribas, Ignas Snellen, Bruce Swinyard, France Allard, Joanna Barstow, James Cho, Athena Coustenis, Charles Cockell, Alexandre Correia, Leen Decin, Remco de Kok, Pieter Deroo, Therese Encrenaz, Francois Forget, Alistair Glasse, Caitlin Griffith, Tristan Guillot, Tommi Koskinen, Helmut Lammer, Jeremy Leconte, Pierre Maxted, Ingo Mueller-Wodarg, Richard Nelson, Chris North, Enric Pallé, Isabella Pagano, Guseppe Piccioni, David Pinfield, Franck Selsis, Alessandro Sozzetti, Lars Stixrude, Jonathan Tennyson, Diego Turrini, Mariarosa Zapatero-Osorio, Jean-Philippe Beaulieu, Denis Grodent, Manuel Guedel, David Luz, Hans Ulrik Nørgaard-Nielsen, Tom Ray, Hans Rickman, Avri Selig, Mark Swain, Marek Banaszkiewicz, Mike Barlow, Neil Bowles, Graziella Branduardi-Raymont, Vincent Coudé du Foresto, Jean-Claude Gerard, Laurent Gizon, Allan Hornstrup, Christopher Jarchow, Franz Kerschbaum, Géza Kovacs, Pierre-Olivier Lagage, Tanya Lim, Mercedes Lopez-Morales, Giuseppe Malaguti, Emanuele Pace, Enzo Pascale, Bart Vandenbussche, Gillian Wright, Gonzalo Ramos Zapata, Alberto Adriani, Ruymán Azzollini, Ana Balado, Ian Bryson, Raymond Burston, Josep Colomé, Martin Crook, Anna Di Giorgio, Matt Griffin, Ruud Hoogeveen, Roland Ottensamer, Ranah Irshad, Kevin Middleton, Gianluca Morgante, Frederic Pinsard, Mirek Rataj, Jean-Michel Reess, Giorgio Savini, Jan-Rutger Schrader, Richard Stamper, Berend Winter, L. Abe, M. Abreu, N. Achilleos, P. Ade, V. Adybekian, L. Affer, C. Agnor, M. Agundez, C. Alard, J. Alcala, C. Allende Prieto, F. J. Alonso Floriano, F. Altieri, C. A. Alvarez Iglesias, P. Amado, A. Andersen, A. Aylward, C. Baffa, G. Bakos, P. Ballerini, M. Banaszkiewicz, R. J. Barber, D. Barrado, E. J. Barton, V. Batista, G. Bellucci, J. A. Belmonte Avilés, D. Berry, B. Bézard, D. Biondi, M. Błęcka, I. Boisse, B. Bonfond, P. Bordé, P. Börner, H. Bouy, L. Brown, L. Buchhave, J. Budaj, A. Bulgarelli, M. Burleigh, A. Cabral, M. T. Capria, A. Cassan, C. Cavarroc, C. Cecchi-Pestellini, R. Cerulli, J. Chadney, S. Chamberlain, N. Christian Jessen, A. Ciaravella, A. Claret, R. Claudi, A. Coates, R. Cole, A. Collur, D. Cordier, E. Covino, C. Danielski, M. Damasso, H. J. Deeg, E. Delgado-Mena, C. Del Vecchio, O. Demangeon, A. De Sio, J. De Wit, M. Dobrijévi, P. Doel, C. Dominic, E. Dorfi, S. Eales, C. Eiroa, M. Espinoza Contreras, M. Esposito, V. Eymet, N. Fabrizio, M. Fernández, B. Femenía Castella, P. Figueira, G. Filacchione, L. Fletcher, M. Focardi, S. Fossey, P. Fouqué, J. Frith, M. Galand, L. Gambicorti, P. Gaulme, R. J. García López, A. Garcia-Piquer, W. Gear, J. -C. Gerard, L. Gesa, E. Giani, F. Gianotti, M. Gillon, E. Giro, M. Giuranna, H. Gomez, I. Gomez-Leal, J. Gonzalez Hernandez, B. GonzÁlez Merino, R. Graczyk, D. Grassi, J. Guardia, P. Guio, J. Gustin, P. Hargrave, J. Haigh, E. Hébrard, U. Heiter, R. L. Heredero, E. Herrero, F. Hersant, D. Heyrovsky, M. Hollis, B. Hubert, R. Hueso, G. Israelian, N. Iro, P. Irwin, S. Jacquemoud, G. Jones, H. Jones, K. Justtanont, T. Kehoe, F. Kerschbaum, E. Kerins, P. Kervell, D. Kipping, T. Koskinen, N. Krupp, O. Lahav, B. Laken, N. Lanza, E. Lellouch, G. Leto, J. Licandro Goldaracena, C. Lithgow Bertelloni, S. J. Liu, U. Lo Cicero, N. Lodieu, P. Lognonné, M. Lopez Puertas, M. A. Lopez Valverde, I. Lundgaard Rasmussen, A. Luntzer, P. Machado, C. Mac Tavish, A. Maggio, J. P. Maillard, W. Magnes, J. Maldonado, U. Mall, J. B. Marquette, P. Mauskopf, F. Massi, A. S. Maurin, A. Medvedev, C. Michaut, P. Miles Paez, M. Montalto, P. Montañés Rodríguez, M. Monteiro, D. Montes, H. Morais, J. C. Morale, M. Morales-Calderón, G. Morello, A. Moro Martín, J. Moses, A. Moya Bedon, F. Murgas Alcaino, E. Oliva, G. Orton, F. Palla, M. Pancrazzi, E. Pantin, V. Parmentier, H. Parviainen, Y. Pena Ramirez, J. Peralta, S. Perez-Hoyos, R. Petrov, S. Pezzuto, R. Pietrzak, E. Pilat-Lohinger, N. Piskunov, R. Prinja, L. Prisinzano, I. Polichtchouk, E. Poretti, A. Radioti, A. Ramos, T. Rank-Luftinger, P. Read, K. Readorn, R. Rebolo Lopez, J. Rebordao, M. Rengel, L. Rezac, M. Rocchetto, F. Rodler, J. Sanchez Bejar, A. Sanchez Lavega, E. Sanroma, N. Santos, J. Sanz Forcada, G. Scandariato, F.- X. Schmider, A. Scholz, S. Scuderi, J. Sethenadh, S. Shore, A. Showman, B. Sicardy, P. Sitek, A. Smith, L. Soret, S. Sousa, A. Stiepen, M. Stolarski, G. Strazzulla, H. M. Tabernero, P. Tanga, M. Tecsa, J. Temple, L. Terenzi, M. Tessenyi, L. Testi, S. Thompson, H. Thrastarson, B. W. Tingley, M. Trifoglio, J. Martin Torres, A. Tozzi, D. Turrini, R. Varley, F. Vakili, M. de Val-Borro, M. L. Valdivieso, O. Venot, E. Villaver, S. Vinatier, S. Viti, I. Waldmann, D. Waltham, D. Ward-Thompson, R. Waters, C. Watkins, D. Watson, P. Wawer, A. Wawrzaszk, G. White, T. Widemann, W. Winek, T. Wi.niowski, R. Yelle, Y. Yung, and S. N. Yurchenko

Subjects
13. Climate action, 7. Clean energy
Published
2015

3. Increased Urinary Albumin Excretion, Insulin Resistance, and Related Cardiovascular Risk Factors in Patients With Type 2 Diabetes

Author

Leonardo Pirro, Vincenzo Trischitta, Antonio Minenna, Oznelle Ludovico, Sandra Mastroianno, Salvatore De Cosmo, and Anna Di Giorgio

Subjects
Advanced and Specialized Nursing, Type 1 diabetes, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Type 2 diabetes, medicine.disease, Insulin resistance, Endocrinology, Diabetes mellitus, Internal medicine, Internal Medicine, Medicine, medicine.symptom, Risk factor, business, Dyslipidemia, Abdominal obesity
Abstract

OBJECTIVE—While the relevant role of insulin resistance in the pathogenesis of increased urinary albumin excretion (UAE) is well established in type 1 diabetes, its contribution in type 2 diabetes is controversial. Our aim was to investigate whether insulin resistance was associated with increased UAE in a large cohort of patients with type 2 diabetes. RESEARCH DESIGN AND METHODS— A total of 363 men and 349 women, aged 61 ± 9 years, with a disease duration of 11 ± 9 years and HbA1c levels of 8.6 ± 2.0% were included. Insulin resistance was derived from the homeostasis model assessment of insulin resistance (HOMAIR), and UAE was derived from the albumin-to-creatinine ratio (ACR) defined as increased if the value was ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women. ACR was correlated with HOMAIR (r = 0.15, P = 0.0001), independently of age, disease duration, blood pressure, HbA1c, triglycerides, waist circumference, and smoking. RESULTS—When the two sexes were investigated separately, a significant correlation between ACR and HOMAIR was reached in men (n = 363; r = 0.21, P = 0.0001) but not women (n = 349; r = 0.08, P = 0.14), suggesting that insulin resistance and sex may interact (P for interaction = 0.04) in determining UAE. When men were subgrouped into quartiles of HOMAIR, those of the third and fourth quartile (i.e., the most insulin resistant) were at higher risk to have increased ACR than patients of the first quartile (third quartile: odds ratio 2.2 [95% CI 1.2–4.2], P = 0.01) (fourth quartile: 4.1 [2.2–7.9], P = 0.00002). Finally, ACR was significantly higher in men with two or more insulin resistance–related cardiovascular risk factors (i.e., abdominal obesity, dyslipidemia, and arterial hypertension) than in men with fewer than two insulin resistance–related cardiovascular risk factors (0.90 [0.2–115.1] vs. 1.56 [0.1–1367.6], respectively, P = 0.005). CONCLUSIONS—In type 2 diabetic patients, increased UAE is strongly associated with insulin resistance and related cardiovascular risk factors. This association seems to be stronger in men than in women.

Published
2005

4. Serum thyroglobulin and 131I whole body scan after recombinant human TSH stimulation in the follow-up of low-risk patients with differentiated thyroid cancer

Author

L. D'Aloiso, Sebastiano Filetti, Guido Valle, Vincenzo Frusciante, Vincenzo Trischitta, Anna Di Giorgio, Umberto Crocetti, Massimo Torlontano, Nazario Bonfitto, Sergio Modoni, Michele Bisceglia, and Martin Schlumberger

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Thyrotropin, Stimulation, Carcinoma, Papillary, Follicular, Thyroglobulin, Metastasis, Iodine Radioisotopes, Endocrinology, Risk Factors, Internal medicine, medicine, Carcinoma, Humans, Thyroid Neoplasms, Radionuclide Imaging, Thyroid cancer, Lymph node, Aged, Ultrasonography, business.industry, Thyroid, General Medicine, Middle Aged, medicine.disease, Recombinant Proteins, medicine.anatomical_structure, Female, business, Follow-Up Studies, Hormone
Abstract

OBJECTIVE: The 'standard' postoperative follow-up of patients with differentiated thyroid cancer (DTC) has been based upon serum thyroglobulin (Tg) measurement and (131)I whole body scan ((131)I-WBS) after thyroid hormone (T(4)) treatment withdrawal. However, (131)I-WBS sensitivity has been reported to be low. Thyroid hormone withdrawal, often associated with hypothyroidism-related side effects, may now be replaced by recombinant human thyroid stimulating hormone (rhTSH). The aim of our study was to evaluate the diagnostic accuracy of (131)I-WBS and serum Tg measurement obtained after rhTSH stimulation and of neck ultrasonography in the first follow-up of DTC patients. DESIGN: Ninety-nine consecutive patients previously treated with total thyroidectomy and (131)I ablation, with no uptake outside the thyroid bed on the post-ablative (131)I-WBS (low-risk patients) were enrolled. METHODS: Measurement of serum Tg and (131)I-WBS after rhTSH stimulation, and ultrasound examination (US) of the neck. RESULTS: rhTSH-stimulated Tg was 1 ng/ml (Tg+) in 21 patients, including 6 patients with Tg levels >5 ng/ml. (131)I-WBS was negative for persistent or recurrent disease in all patients (i.e. sensitivity = 0%). US identified lymph-node metastases (confirmed at surgery) in 4/6 (67%) patients with stimulated Tg levels >5 ng/ml, in 2/15 (13%) with Tg>1

Published
2003

5. Comparative evaluation of recombinant human thyrotropin-stimulated thyroglobulin levels, 131I whole-body scintigraphy, and neck ultrasonography in the follow-up of patients with papillary thyroid microcarcinoma who have not undergone radioiodine therapy

Author

Massimo Torlontano, Franca Dicembrino, Nazario Bonfitto, Sebastiano Filetti, Anna Di Giorgio, Umberto Crocetti, Sergio Modoni, L. D'Aloiso, Rocco Bruno, Giovanni Augello, Vincenzo Trischitta, Antonio Varraso, and Vincenzo Frusciante

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Thyrotropin, Context (language use), Scintigraphy, Biochemistry, Thyroglobulin, Whole-Body Counting, Thyroid carcinoma, Iodine Radioisotopes, Endocrinology, Thyroid-stimulating hormone, Recurrence, Internal medicine, Carcinoma, Medicine, Humans, Gamma Cameras, Thyroid Neoplasms, Radionuclide Imaging, Lymph node, Ultrasonography, medicine.diagnostic_test, business.industry, Biochemistry (medical), Thyroid, Middle Aged, medicine.disease, Carcinoma, Papillary, Recombinant Proteins, medicine.anatomical_structure, Female, business, Neck
Abstract

Although the prognosis of papillary thyroid microcarcinoma (PTMC) is usually excellent, the optimal follow-up strategy has never been investigated.The objective of the study was to investigate the role of neck ultrasonography (US), whole-body scintigraphy (WBS), and serum thyroglobulin levels (Tg) after recombinant human (rh) TSH in the follow-up of very low-risk PTMC patients.The study was a 5-yr observational study based on a 6- to 12-month follow-up after near total thyroidectomy.The study population consisted of ambulatory patients.Eighty consecutive patients diagnosed with PTMC, who had not undergone postoperative radioiodine treatment because of unifocal tumor without lymph node metastases and who did not have anti-Tg antibodies, were included.WBS and Tg after both rhTSH and neck US were measured.rhTSH-Tg was 1 ng/ml or less in 45 (Tg-) and more than 1 in 35 (Tg+) patients. WBS showed no pathological uptake in any patient. US identified node metastases in two Tg (+) and one Tg (-) patients. rhTSH-Tg levels positively correlated with thyroid bed iodine uptake (r = 0.40, P0.0001). To date (32 +/- 13 months after surgery), all node-negative patients have undetectable Tg levels on LT(4) treatment and negative US.For the initial follow-up of PTMC patients without risk factors and anti-Tg antibodies and who did not undergo radioiodine treatment: 1) WBS is useless; 2) US is highly sensitive in detecting node metastases; and 3) detectable rhTSH-Tg levels mainly depend on small normal tissue remnants. In this subgroup of PTMC patients, neck US might be regarded as a primary tool for the initial follow-up.

Published
2005

6. Increased urinary albumin excretion, insulin-resistance and related cardiovascular risk factors in patients with type 2 diabetes: evidence of a gender-specific association

Author

Salvatore, De Cosmo, Antonio, Minenna, Oznelle, Ludovico, Sandra, Mastroianno, Anna, Di Giorgio, Leonardo, Pirro, and Vincenzo, Trischitta

Subjects
Glycated Hemoglobin, Male, Blood Pressure, Middle Aged, White People, Body Mass Index, Cohort Studies, Diabetes Mellitus, Type 2, Italy, Cardiovascular Diseases, Risk Factors, Creatinine, Albuminuria, Humans, Female, Insulin Resistance, Diabetic Angiopathies, Aged
Abstract

While the relevant role of insulin resistance in the pathogenesis of increased urinary albumin excretion (UAE) is well established in type 1 diabetes, its contribution in type 2 diabetes is controversial. Our aim was to investigate whether insulin resistance was associated with increased UAE in a large cohort of patients with type 2 diabetes.A total of 363 men and 349 women, aged 61 +/- 9 years, with a disease duration of 11 +/- 9 years and HbA(1c) levels of 8.6 +/- 2.0% were included. Insulin resistance was derived from the homeostasis model assessment of insulin resistance (HOMA(IR)), and UAE was derived from the albumin-to-creatinine ratio (ACR) defined as increased if the value wasor =2.5 mg/mmol in men andor =3.5 mg/mmol in women. ACR was correlated with HOMA(IR) (r = 0.15, P = 0.0001), independently of age, disease duration, blood pressure, HbA(1c), triglycerides, waist circumference, and smoking.When the two sexes were investigated separately, a significant correlation between ACR and HOMA(IR) was reached in men (n = 363; r = 0.21, P = 0.0001) but not women (n = 349; r = 0.08, P = 0.14), suggesting that insulin resistance and sex may interact (P for interaction = 0.04) in determining UAE. When men were subgrouped into quartiles of HOMA(IR), those of the third and fourth quartile (i.e., the most insulin resistant) were at higher risk to have increased ACR than patients of the first quartile (third quartile: odds ratio 2.2 [95% CI 1.2-4.2], P = 0.01) (fourth quartile: 4.1 [2.2-7.9], P = 0.00002). Finally, ACR was significantly higher in men with two or more insulin resistance-related cardiovascular risk factors (i.e., abdominal obesity, dyslipidemia, and arterial hypertension) than in men with fewer than two insulin resistance-related cardiovascular risk factors (0.90 [0.2-115.1] vs. 1.56 [0.1-1367.6], respectively, P = 0.005).In type 2 diabetic patients, increased UAE is strongly associated with insulin resistance and related cardiovascular risk factors. This association seems to be stronger in men than in women.

Published
2005

7. Combined 17a-hydroxylase/17-20-lyase deficiency caused by Phe93Cys mutation in the CYP17 gene

Author

Alfredo Di Cerbo, Anna Biason-Lauber, Maria Savino, Anna Di Giorgio, Maria Rosaria Piemontese, Anna Savoia, Marco Perona, DI CERBO, A, BIASON LAUBER, A, Savino, M, Piemontese, Mr, DI GIORGIO, A, Perona, M, and Savoia, Anna

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Molecular Sequence Data, Consanguinity, Human leukocyte antigen, Biology, medicine.disease_cause, Biochemistry, Dexamethasone, Endocrinology, Metabolic Diseases, Internal medicine, medicine, Missense mutation, Humans, Congenital adrenal hyperplasia, Glucocorticoids, Conserved Sequence, Genetics, Mutation, Adrenal Hyperplasia, Congenital, Base Sequence, Sexual Differentiation Disorder, Biochemistry (medical), Haplotype, Steroid 17-alpha-Hydroxylase, Sexual Infantilism, Middle Aged, medicine.disease, Hormones, Pedigree, Amino Acid Substitution, Female, Microsatellite Repeats
Abstract

Seventeen alpha-hydroxylase/17,20-lyase deficiency is a rare, autosomal recessive form of congenital adrenal hyperplasia not linked to human leukocyte antigen and characterized by the coexistence of hypertension caused by the hyperproduction of mineralocorticoid precursors and sexual abnormalities, such as male pseudohermaphroditism and sexual infantilism in female, due to impaired production of sex hormones. Both 17alpha-hydroxylase and 17,20-lyase reactions are catalyzed by a single polypeptide, cytochrome P450c17 (CYP17), which is encoded by the CYP17 gene located on chromosome 10q24-q25. Mutations in the CYP17 gene have been recognized to cause the 17alpha-hydroxylase/17,20-lyase deficiency syndrome. Here, we describe two phenotypically and hormonally affected Italian patients with 17alpha-hydroxylase/17,20-lyase deficiency. The family history revealed consanguinity of the parents. Linkage and haplotype analyses using microsatellites on chromosome 10q24-q25 demonstrated that the two affected individuals were homozygous at these loci. The mutation screening of the CYP17 gene identified a new Phe93Cys missense mutation in exon 1. The amino acid substitution is located in a highly conserved region of the protein and is not a polymorphism because it is not present in one hundred normal alleles. In vitro functional studies showed that the Phe93Cys mutated CYP17 retains only 10% of both 17alphahydroxylase and 17,20-lyase activities, according to the severe phenotype. Our results shed more light on the structure-function relationship of the CYP17 protein indicating that Phe 93 is crucial for both enzymatic activities.

Published
2002

8. Skeletal involvement in female acromegalic subjects: the effects of growth hormone excess in amenorrheal and menstruating patients

Author

Sergio Modoni, Vincenzo Carnevale, Alfredo Di Cerbo, Giuseppe Guglielmi, Giuseppe Maria Giannatempo, Saverio Fusilli, Anna Di Giorgio, Mauro Pileri, Vincenzo Frusciante, Antonio Liuzzi, Alfredo Scillitani, Iacopo Chiodini, and Massimo Villella

Subjects
Adult, Deoxypyridinoline, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Osteocalcin, Bone remodeling, chemistry.chemical_compound, Bone Density, Internal medicine, Acromegaly, medicine, Humans, Orthopedics and Sports Medicine, Quantitative computed tomography, Amino Acids, Insulin-Like Growth Factor I, Amenorrhea, Femoral neck, Aged, Bone mineral, Analysis of Variance, Pyridinoline, Bone Development, medicine.diagnostic_test, business.industry, Estrogens, Middle Aged, medicine.disease, Alkaline Phosphatase, Urinary calcium, Peptide Fragments, Menstruation, medicine.anatomical_structure, Endocrinology, chemistry, Creatinine, Growth Hormone, Calcium, Female, business, Biomarkers, Procollagen
Abstract

Bone involvement is a common clinical feature in acromegalic patients, though previous studies gave divergent results possibly because of the different gonadal status of the patients studied. To study the influence of estrogen milieu in these patients, we evaluated 23 acromegalic patients with active disease, subdivided into two groups: menstruating and amenorrheal patients, comparable for duration and activity of disease. Forty-two matched women served as controls. Skeletal involvement was studied by measuring: (a) the main biomarkers of bone turnover: serum alkaline phosphatase total activity (AP), bone GLA protein (BGP), serum carboxy-terminal propeptide of type I collagen (PICP), serum type I cross-linked N-telopeptide (ICTP), and urinary pyridinoline and deoxypyridinoline corrected for creatinine (Pyr/Cr, D-Pyr/Cr) and urinary calcium/creatinine ratio (Ca/Cr); (b) bone mineral density (BMD), as measured by quantitative computed tomography both at lumbar spine and distal radius, and by dual X-ray absorptiometry both at lumbar spine and at three femoral sites (Ward's triangle, femoral neck, and great trochanter). AP, BGP, ICTP, Pyr/Cr, D-Pyr/Cr were significantly higher in patients than in controls, independent of the menstrual pattern. Higher PICP levels were found in the whole group and in menstruating acromegalics when compared with control women; no difference was found in amenorrheal patients, who in turn showed higher urinary Ca/Cr values. When patients were considered all together, BMD at spine, femoral neck, and trochanter was higher than in controls. In contrast, when the gonadal status was taking into account and, menstruating and amenorrheal subjects were considered separately, BMD at spine, but not in other sites, was significantly higher in menstruating patients than in controls. In contrast, no difference of BMD values at any site was observed between amenorrheal patients and controls. The mean BMD Z scores allowed us to detect an unequal involvement of different skeletal sites. Our results show that bone turnover is increased in acromegalic women and suggest that GH anabolic effect on bone is more evident in the presence of estrogens and that different skeletal sites may be affected differently by hormone excess.

Published
1997

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