41 results on '"Anna Claudia Pellicelli"'
Search Results
2. The role of big data in shaping ambidextrous business process management: Case studies from the service industry.
- Author
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Luca Dezi, Gabriele Santoro, Heger Gabteni, and Anna Claudia Pellicelli
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- 2018
- Full Text
- View/download PDF
3. Somebody is hiding something: Disentangling interpersonal level drivers and consequences of knowledge hiding in international entrepreneurial firms
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Hannan Amoozad Mahdiraji, Anna Claudia Pellicelli, Alain Devalle, and Vahid Jafari-Sadeghi
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Marketing ,Knowledge management ,business.industry ,Comparative analysis ,DEMATEL ,Context (language use) ,Interpersonal communication ,SWARA ,Multiple-criteria decision analysis ,Interpersonal level factors ,Conceptual framework ,Ranking ,Knowledge hiding ,Order (exchange) ,Sociology ,International entrepreneurs ,Emerging markets ,business ,Set (psychology) - Abstract
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. This research is set to address the scant research on the relationship between the key drivers and consequences of knowledge hiding within international entrepreneurial organisations at the interpersonal level. It further aims to compare knowledge hiding behaviour among international entrepreneurs in two diverse contexts of emerging countries versus advanced economies. Therefore, this research employs a total number of ten international entrepreneurs in Iran and Italy and takes advantage of the Multi-Criterion Decision-Making (MCDM) approach. In this regard, DEcision-MAking Trial and Evaluation Laboratory (DEMATEL) method is applied to disentangle the cause-effect relationship between knowledge hiding components and present conceptual frameworks for the interrelationship of knowledge hiding factors in each context. Furthermore, in order to assess the importance and ranking of factors in Italy and Iran Weight Assessment Ratio Analysis (SWARA) is performed. As such, this research provides different contributions to the knowledge hiding literature as well as key implications for practitioners.
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- 2022
4. The Power of the Omnichannel Strategy and the Role of Marketing in This Challenge: An Abstract
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Anna Claudia Pellicelli and Carola Romana Garrone
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- 2023
5. Cultural Heritage Tradition and Innovation in the Internationalization of Family Business: A Case Study from the Italian Fashion Industry
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Anna Claudia Pellicelli and Erica Varese
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family business ,Family business ,fashion industry ,Business administration ,05 social sciences ,Fashion industry ,tradition ,02 engineering and technology ,innovation ,case study ,Internationalization ,0502 economics and business ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,country of origin, radio frequency identification (RFId), fashion industry, family business, case study, tradition, innovation, internationalization ,Business ,radio frequency identification (RFId) ,internationalization ,country of origin ,050203 business & management - Abstract
The fashion industry is one of the main businesses in the global economy in terms of employment, investment, trade and revenue and Italian companies are worldwide recognized as representative of cultural heritage, expertise and high-quality standards. The adoption of traceability technologies, such as Radio Frequency Identification (RFId), from the very early stage of the production chain, may help to obtain a more effective process and may also assure the origin of the garments, a key aspect in the fashion industry. The chapter aims at presenting an Italian family business, Oscalito, which has adopted the RFId technology, joining tradition and innovation in its production. A qualitative case study methodology has been adopted, to explore this experience within its context. Oscalito has applied RFId tags to each label, to ensure complete traceability throughout the production chain for each single item (and not merely by lots), fine-tuned control over the production process, and timely and accurate shipment. Thanks to their application, the production chain has been monitored and the Italian origin of the garments has been guaranteed. This research has undoubtedly some limitation due to the applied method. Deeper studies are requested in order to check a general fashion industry trend with reference to the application of RFId technology.
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- 2022
6. Over the mask of innovation management in the world of Big Data
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Jens Muller, Anna Claudia Pellicelli, Alberto Mazzoleni, Francesco Caputo, Caputo, Francesco, Mazzoleni, Alberto, Pellicelli Anna, Claudia, and Muller, Jens
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Marketing ,Entrepreneurship ,Knowledge management ,Systems thinking ,business.industry ,media_common.quotation_subject ,05 social sciences ,Big data ,Innovation management ,Service (economics) ,Return on investment ,0502 economics and business ,Service logic ,050211 marketing ,business ,Human resources ,Research question ,050203 business & management ,media_common - Abstract
Big Data is one of the most debated topics, as its implications for innovation management and entrepreneurship development are attracting interest from researchers and practitioners. Despite the increasing interest on this topic, a relevant research question remains unsolved: what are the conditions required for the effective management of Big Data? Adopting the interpretative lens provided by Systems Thinking and Service Logic, a set of hypotheses are defined and tested through the Partial Least Squares (PLS), with reference to the 50 Big Data companies for 2017 as identified by Big Data Quarterly. The results show that several elements such as company's investment in innovation and technology and specialization of human resource positively impact on Big Data Companies' Return on Investment (ROI). Results and discussions herein enrich previous managerial debate about the domain of Big Data highlighting ‘tangible’ elements on which act for improving innovation management approaches for companies.
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- 2020
7. 'Openness' of public governments in smart cities: removing the barriers for innovation and entrepreneurship
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Alberto Ferraris, Gabriele Santoro, and Anna Claudia Pellicelli
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Entrepreneurship ,05 social sciences ,Context (language use) ,Creating shared value ,Management Information Systems ,Procurement ,Urban planning ,Management of Technology and Innovation ,Smart city ,0502 economics and business ,Openness to experience ,050211 marketing ,Business ,Marketing ,050203 business & management ,Open innovation - Abstract
Open innovation practices have been found to positively affect innovation and entrepreneurship due to the complementarities and uniqueness of resources and knowledge provided by each organization. Today, this approach may be even more important in the so called “smart cities”, where different private and public stakeholders cooperate to co-design and co-develop new cutting edge products and services aimed to create shared value through entrepreneurial behaviors. However, concrete examples of smart city projects revealed that public governments often do not have the necessary capabilities as well as innovative approaches to collaborate with companies and other stakeholders’ ecosystems. So, this paper aims at analyzing (open) innovation in public governments shedding lights on the barriers and challenges that public governments face in smart city development. The study uses primary data gathered through interviews from multiple smart city stakeholders to highlight how public governments should operate in the smart city context to overcome barriers and challenges, and to favor an entrepreneurial and innovation ecosystem as well as public-private collaborations. These barriers are related to: lack of rules; as all the others tasks and responsibility; scarce integrated view of the city planning; lack of fit of administrative styles & interdepartmental coordination and communication; risk adversity; data availability; disincentives & non flexible public procurement rules; lack of resources; lack of technological capabilities. Moreover, the study provides contributions for different and interrelated streams of research, in particular developing several implications in the field of entrepreneurship and smart city.
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- 2020
8. Testing the antecedents of customer knowledge sharing on social media: a quantitative analysis on Italian consumers
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Gabriele Baima, Gabriele Santoro, Anna Claudia Pellicelli, and Maciej Mitręga
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Marketing ,Business and International Management - Abstract
PurposeThe increasing adoption of digital technologies such as social media have changed the way consumers share knowledge about products and services among each other. The aim of this paper is to test what factors drive customers to share knowledge about products and services on social media pages.Design/methodology/approachA quantitative survey design was employed for this study. Empirical data were drawn from 358 consumers in Italy, using a purposive sampling technique. The hypothesised relationships were tested using ordinary least squares regression modelling.FindingsThe results of this study reveal that the usage frequency of online reviews (UFORs), social bonds (SBs), subjective happiness (SH) and reciprocity positively impact on customer knowledge sharing (CKS). By contrast, the perceived usefulness of online reviews (PUORs), helping others, customer susceptibility to interpersonal influence (CSII) and informational (INFO) do not impact CKS.Originality/valueTo the best of the authors' knowledge, this study is amongst the first to empirically test the antecedents of knowledge-sharing behaviours about products and services on online social media. The present work offers relevant implications for theory. First, the work enriches the customer knowledge management (CKM) theory by providing empirical evidence on factors leading to the higher sharing of knowledge amongst customers. Second, the work adds to the literature on social media, demonstrating the individual determinants on knowledge-sharing behaviours about products and services in online communities. Practically speaking, this paper identifies some key elements driving CKS in social media conversations. Thus, building upon the findings of this study, the authors provide some guidelines for social media managers and retailers for promoting CKS on social media pages.
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- 2022
9. Exploring e-Loyalty Antecedents in B2C e-Commerce
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Lamberto Zollo, Anna Claudia Pellicelli, Monica Faraoni, and Riccardo Rialti
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business.industry ,Website design ,05 social sciences ,Context (language use) ,E-commerce ,Investment (macroeconomics) ,Structural equation modeling ,Grocery retailing ,E loyalty ,Phenomenon ,0502 economics and business ,ComputingMilieux_COMPUTERSANDSOCIETY ,Business, Management and Accounting (miscellaneous) ,050211 marketing ,Business ,Marketing ,050203 business & management ,Food Science - Abstract
PurposeThe purpose of this paper is to investigate the micro-linkages fostering consumers’ e-loyalty in grocery retailers B2C e-commerce context. Specifically, the authors focused on the neglected role of security, privacy and website design. Grocery retailing has been selected as the context of research because grocery retailers too have been required to develop B2C e-commerce platforms to meet their consumers’ evolving preferences.Design/methodology/approachA survey was distributed to several students from University of Florence (Italy). Structural equation modeling was used to compile the research, and its results reflect the impact on e-loyalty development on specific features of the e-commerce environment.FindingsThe main findings of this research are related with the importance of website characteristics as antecedents of e-loyalty in online grocery retailing.Originality/valueAlbeit the explored phenomenon has been subject to extensive study, some of its facets are yet to be fully explored. In particular, though the influence of e-trust, e-satisfaction and e-commitment on e-loyalty has been shown, little attention has been paid to the factors affecting these three antecedents of e-loyalty. In this regard, this research focuses on the importance of B2C e-commerce platform characteristics such as security, perceived relationship investment and website design. In addition, the phenomenon was scarcely explored in grocery retailers B2C e-commerce context.
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- 2019
10. Private Label and Brand Equity. Opportunities in New Trends
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Anna Claudia Pellicelli
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Private label ,media_common.quotation_subject ,Loyalty ,Equity (finance) ,Context (language use) ,Brand equity ,Business ,Market power ,Marketing ,Consumer behaviour ,media_common ,Brand loyalty - Abstract
The global pandemic has reshaped the scenario for marketing organizations across several industries, as the former apparently represents one of the most remarkable environmental changes in modern marketing history, with relevant consequences on consumer behaviour. Overall, the latter had more time at home, which resulted in new habits and new opportunities of engagement. In this context it is becoming more and more important to study the relationship between the magnitude of brand loyalty and store loyalty as PLs enhance customer store loyalty. PLs have been able to build brand equity throughout their development, with considerable differences across product categories. The aim of the paper is to analyse the components of Private Label equity and the positive relation between PL loyalty and store loyalty: PLs enhance customer store loyalty, setting the basis for further research in this field. Higher level of PL brand equity reduces the price competition between PLs and NBs and enhances their differentiation, which allows more market power for both.
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- 2021
11. Context-specific micro-foundations and successful SME internationalisation in emerging markets: A mixed-method analysis of managerial resources and dynamic capabilities
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Anna Claudia Pellicelli, Vahid Jafari-Sadeghi, Stefano Bresciani, and Hannan Amoozad Mahdiraji
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Marketing ,Dynamic capabilitiesI ,Knowledge management ,Mixed-method analysis ,business.industry ,media_common.quotation_subject ,05 social sciences ,Emerging markets ,ISM MICMAC ,Context (language use) ,SME internationalisation ,international networking and vision ,Internationalization ,Resource (project management) ,Conceptual framework ,0502 economics and business ,050211 marketing ,Dynamic capabilities ,SME internationalisation, Dynamic capabilitiesI,international networking and vision ,Emerging markets ,Mixed-method analysis, ISM MICMAC ,business ,Function (engineering) ,Competence (human resources) ,050203 business & management ,media_common - Abstract
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Building on the resource-based view, this study aims to address the scant research on the context-specific micro-foundations that impact on internationalisation of SMEs in emerging markets. Therefore, the paper explores managerial resources and dynamic capabilities in three categories of international networking, vision, and experience and competence. In this regard, we employ a mixed-method analysis and focus on Iran as representative of a low supportive institutional context for SME internationalisation belongs to emerging markets. Hence, in qualitative analysis, we utilise multiple case study and conduct ten interviews, which led to the identification of fourteen important managerial resources and capabilities. This is followed by expert-based decision-making approaches, taking advantage of interpretive structural modelling (ISM) and Matrix-based Multiplication Applied to a Classification (MICMAC), which contributed to investigation the relative function of identified factors as well as proposing a conceptual framework for the inter- and cross-relationships among explored drivers in three targeted categories and provides theoretical and practical suggestions.
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- 2021
12. The Impact of Customer Education on the Perception of Made in Italy Products in the Agri-Food Sector
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Anna Claudia Pellicelli and Claudia Franze
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COVID-19 Pandemic ,Food industry ,media_common.quotation_subject ,Customer Training ,Made in Italy ,Perception ,Food Industry ,International Strategies ,customer education ,made in Italy, customer education, agri food products ,Marketing ,Italian Manufacturing ,made in Italy ,media_common ,Food Experience ,Value creation ,Value Creation ,business.industry ,Experiential Marketing ,Food experience ,Country of origin ,Country of Origin, COVID-19 Pandemic, Culinary Practices, Customer Training, Experiential Marketing, Food Experience, Food Industry, International Strategies, Italian Manufacturing, Value Creation ,Food sector ,Experiential marketing ,Country of Origin ,agri food products ,Business ,Culinary Practices - Abstract
While the global COVID-19 pandemic affected all the industries, the Italian agri-food sector positively performed over this period, supported by the exports, underlining the need for new international strategies to authentically engage consumers. This study aims to investigate the impact of customer education (CE) on the perceptions and evaluations of foreign consumers towards Made in Italy products as a part of the food experience in the agri-food sector. After a literature review, the paper illustrates the main topics of customer education, food experience and country-of-origin (COO) effect of Made in Italy. The purposes of the conceptual paper relate to the strategic use of country-of-origin effect by companies in order to promote products and services in foreign markets, and to the analysis of the impact of customer education within the food sector on the perception of Made in Italy products taking into account the new challenges of the current situation.
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- 2021
13. The RFId Technology for Monitoring the Supply Chain and for Fighting against Counterfeiting: A Fashion Company Case Study
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Erica Varese and Anna Claudia Pellicelli
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RFId ,case study ,Commerce ,Computer science ,Supply chain ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,label ,counterfeiting ,fashion company ,supply chain ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Published
- 2020
14. Investigating why online purchasing push offline sales in the luxury market
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Anna Claudia Pellicelli and Claudia Franze
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customer experience ,offline experience ,omnichannel ,online behaviour ,Advertising ,luxury brands ,Business ,Purchasing - Published
- 2020
15. Listen - e-Book : Libere conversazioni sul brand e la consumer obsession
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Anna Claudia Pellicelli, Marco Andrea Tolentino, Anna Claudia Pellicelli, and Marco Andrea Tolentino
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- 2021
16. Analysis of resistance and phylogenetic clusters in HCV-2c infected patients within the Italian network Vironet C
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Anna Claudia Pellicelli, Alessandro Pieri, Enzo Boeri, V. Pace Palitti, Roberto Gulminetti, V. Di Marco, Stefania Paolucci, Simona Landonio, F. Di Lorenzo, Laura Monno, L. Sarmati, Stefano Novati, Annapaola Callegaro, Simona Marenco, G. Raimondo, Lavinia Fabeni, Maurizio Zazzi, Silvia Barbaliscia, Nicola Coppola, P. Andreone, L. Carioti, Claudio Maria Mastroianni, Anna Licata, Fausto Baldanti, M. Andreoni, M. Quartini, M. Lichtner, Gloria Taliani, Laura Ambra Nicolini, Francesca Ceccherini-Silberstein, C.F. Perno, Luca Foroghi, Giustino Parruti, Bianca Bruzzone, Caterina Pasquazzi, C. Paternoster, Martina Milana, Sergio Babudieri, K. Yu La Rosa, M. Puoti, Hamid Hasson, Teresa Pollicino, N. Iapadre, C. Minichini, Raffaele Cozzolongo, Valeria Micheli, Barbara Rossetti, Aldo Bertoli, Elisabetta Teti, Marianna Aragri, Antonio Craxì, Filomena Morisco, V.C. Di Maio, Vincenzo Sangiovanni, Leonardo Baiocchi, and Mario Angelico
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Genetics ,Hepatology ,Resistance (ecology) ,Phylogenetic tree ,business.industry ,Gastroenterology ,Medicine ,business - Published
- 2020
17. VIRONET-C real life experience of resistance-guided retreatment in HCV infected patients who previously failed a NS5A inhibitor-containing regimen
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Mario Starace, Valerio Giannelli, Nunzia Cuomo, Vanni Borghi, Aldo Bertoli, Anna Licata, Anna Claudia Pellicelli, C. Minichini, M. Andreoni, M. Di Stefano, Giuseppe Cariti, Enzo Boeri, Raffaele Cozzolongo, Roberto Gulminetti, E. Milano, Valeria Cento, Elisabetta Degasperi, Laura Sighinolfi, A. Raddi, Ivana Maida, Barbara Rossetti, Teresa Santantonio, Valeria Micheli, C. Masetti, P. Andreone, Giustino Parruti, F. Di Lorenzo, Ilaria Lenci, Tiziano Allice, Annapaola Callegaro, Elisa Biliotti, M. Lichtner, Teresa Pollicino, Pietro Lampertico, Gloria Taliani, Caterina Pasquazzi, Piero Colombatto, Alessia Giorgini, G. Raimondo, Antonio Craxì, Francesca Ceccherini-Silberstein, Filomena Morisco, Valeria Ghisetti, V.C. Di Maio, Giuliano Rizzardini, Silvia Galli, Stefania Paolucci, A. De Santis, A. Lleo, Vincenzo Sangiovanni, A. Ciancio, Maurizio Zazzi, Elisabetta Teti, Simona Marenco, William Gennari, Stefano Novati, Giovanni Cenderello, Simona Landonio, Manuela Merli, A. Scuteri, Nicola Coppola, C.F. Perno, Giulia Morsica, I. Beretta, Claudio Maria Mastroianni, Simona Francioso, Mario Angelico, Laura Ambra Nicolini, Chiara Dentone, Silvia Barbaliscia, G.B. Gaeta, Marianna Aragri, Ennio Polilli, L. Donnarumma, Vincenza Calvaruso, Bianca Bruzzone, Fausto Baldanti, V. Pace Palitti, Roberto Ganga, Maurizia Rossana Brunetto, C. Paternoster, Sergio Babudieri, M. Puoti, Hamid Hasson, and M. Rendina
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medicine.medical_specialty ,Regimen ,Hepatology ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,business ,NS5A - Published
- 2020
18. Product Risks and Life Cycle
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Erica Varese, Luigi Bollani, and Anna Claudia Pellicelli
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business.industry ,Automotive industry ,Specific risk ,Sample (statistics) ,Business risks ,Product risk ,Product life cycle ,Risk management ,Documentation ,Product lifecycle ,Product (category theory) ,Marketing ,business - Abstract
The purpose of this paper is to analyse the progress of risk management and the tools that can help companies to better deal with the risks they face. The research carried out on a sample of companies from different sectors offers confirmation and new conviction. The documentation collected was examined by asking four questions. Is there a specific risk management function? With which risks does it deal in particular? Which policies? What place does risk management have in the organisation? The main conclusions reached by authors have been compared with what companies do in reality. For this purpose, a sample of companies from the automotive, pharmaceutical, electronic, air transport and mass retail sectors was chosen.
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- 2019
19. The interplay among entrepreneur, employees, and firm level factors in explaining SMEs openness: A qualitative micro-foundational approach
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Roberto Quaglia, Anna Claudia Pellicelli, Gabriele Santoro, and Paola De Bernardi
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Theory building ,020209 energy ,media_common.quotation_subject ,Micro-foundations ,Context (language use) ,02 engineering and technology ,Management of Technology and Innovation ,0502 economics and business ,0202 electrical engineering, electronic engineering, information engineering ,Openness to experience ,Entrepreneur ,Business and International Management ,Applied Psychology ,Open innovation ,media_common ,Small and medium enterprises ,Delegation ,Business administration ,05 social sciences ,Perspective (graphical) ,Business ,Small and medium-sized enterprises ,Risk taking ,050203 business & management - Abstract
This paper seeks to investigate the micro-foundations of engaging in open innovation (OI) in the context of small and medium enterprises (SMEs). More specifically, the study aims to understand the characteristics of entrepreneurs managing small companies and whether these influence the proclivity towards openness. A theory building approach is applied with an exploratory multiple case-study analysis consisting of eight Italian SMEs operating in knowledge intensive sectors. The information gathered through interviews indicate that several factors and variables related to the entrepreneur, employees and firm level have an impact on the propensity towards engaging in OI. Regarding the entrepreneur, delegation, trust in internal and external partners, individual ties and risk taking approach increase the approach towards OI. Moreover, it has emerged that several factors regarding employees contribute to establishing OI strategies. The interviews have also underlined that entrepreneur level factors have an impact on employee level factors in the sense that their joint effect leads to increased openness. These factors are also influenced by firm level factors. In terms of implications, this is one of the first studies on the micro-foundations of OI and, to the best of our knowledge, the first taking the entrepreneur perspective.
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- 2019
20. Real-world data on the treatment of primary biliary cholangitis with obeticholic acid in Italy: the CLEO-AIGO OCA cohort
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Alessandro Mussetto, Anna Claudia Pellicelli, A. De Vincentis, Luchino Chessa, Rodolfo Sacco, Floriano Rosina, E. Frazzetto, Alessandra Picardi, Marco Distefano, Ernesto Claar, Raffaele Cozzolongo, Antonio Izzi, Valentina Feletti, R. Fontana, Gaetano Bertino, Michela Barlattani, M. D’Antò, Maurizio Russello, M.R. Cannavò, V. Pace-Palitti, Umberto Vespasiani-Gentilucci, Grazia Anna Niro, G. Scifo, S. Storato, and Giovanni Galati
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chemistry.chemical_compound ,medicine.medical_specialty ,Hepatology ,chemistry ,business.industry ,Internal medicine ,Cohort ,Gastroenterology ,Obeticholic acid ,Medicine ,business ,Real world data - Published
- 2020
21. The role of big data in shaping ambidextrous business process management: case studies from the service industry
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Anna Claudia Pellicelli, Gabriele Santoro, Luca Dezi, and Heger Gabteni
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Knowledge management ,business.industry ,Business process ,media_common.quotation_subject ,05 social sciences ,Big data ,Business process management ,Empirical research ,Software deployment ,Service (economics) ,0502 economics and business ,Business, Management and Accounting (miscellaneous) ,050211 marketing ,Business and International Management ,business ,Empirical evidence ,050203 business & management ,media_common ,Ambidexterity - Abstract
Purpose The purpose of this paper is to explore how big data can shape ambidextrous business process management (BPM) in terms of exploitation and exploration. Design/methodology/approach A qualitative methodology involving case studies has been chosen to explore the impact of big data deployment on exploitative and explorative business processes. Findings The results of case studies offer some opportunities and challenges for service firms related to both the exploitative and the explorative aspects of BPM driven by big data. Originality/value The deployment of big data in business processes has attracted a large amount of interest recently. However, these studies are mostly conceptual, so empirical research about this complex relationship is quite rare, especially research with specific arguments regarding exploitative and explorative activities. This paper aims to fill this gap by offering empirical evidence for big data-driven business processes.
- Published
- 2018
22. Characterization of baseline factors associated with treatment outcome in HCV-infected patients naive to direct acting antivirals: particular focus on natural resistance
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M. Siciliano, Giulia Morsica, Anna Claudia Pellicelli, Silvia Galli, F. Ceccherini-Silberstein, Fausto Baldanti, Bianca Bruzzone, R. Campoli, Giuliano Rizzardini, Vincenza Calvaruso, Gloria Taliani, V. Pace Palitti, C. Masetti, P Paba, Antonio Craxì, Filomena Morisco, Ennio Polilli, V.C. Di Maio, Martina Milana, William Gennari, C.F. Perno, Rossana Scutari, Aldo Bertoli, Valeria Cento, M. Andreoni, V. Boccaccio, Marianna Aragri, G.B. Gaeta, M. Lichtner, Caterina Pasquazzi, Vanni Borghi, Laura Ambra Nicolini, Renato Maserati, G. Fiorentino, Sergio Babudieri, Elisabetta Degasperi, Giustino Parruti, Mario Angelico, L. Foroghi, Valeria Ghisetti, Silvia Barbaliscia, Carlo Magni, Valeria Micheli, Elisabetta Teti, Nicola Coppola, Stefania Paolucci, L. Sarmati, R. D’Ambrosio, Pietro Lampertico, M. Puoti, N. Iapadre, Stefano Bonora, and V. Guarneri
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Natural resistance ,Oncology ,Focus (computing) ,medicine.medical_specialty ,Hepatology ,business.industry ,Internal medicine ,Treatment outcome ,Gastroenterology ,medicine ,Baseline (configuration management) ,DIRECT ACTING ANTIVIRALS ,business - Published
- 2019
23. Resistance test guided retreatment of HCV infected patients with a previous failure to a NS5A inhibitor-containing regimen: the Italian Vironet C real life experience
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Pietro Lampertico, Valeria Cento, Claudio Maria Mastroianni, M. Puoti, Giuliano Rizzardini, Maurizio Zazzi, M. Lichtner, Bianca Bruzzone, Ivana Maida, Elisabetta Degasperi, C.F. Perno, M. Rendina, Giustino Parruti, Vincenza Calvaruso, Gloria Taliani, F. Di Lorenzo, Ilaria Lenci, Anna Claudia Pellicelli, Caterina Pasquazzi, Stefania Paolucci, A. Raddi, Marianna Aragri, Ennio Polilli, Giulia Morsica, Mario Starace, M. Andreoni, M. Di Stefano, C. Minichini, L. Donnarumma, V. Guarneri, Simona Marenco, Simona Landonio, Raffaele Cozzolongo, V. Pace Palitti, N. Cuomo, P. Andreone, Nicola Coppola, Silvia Galli, Mario Angelico, C. Paternoster, Roberto Ganga, Vanni Borghi, Elisabetta Teti, Sergio Babudieri, Silvia Barbaliscia, Anna Licata, Giovanni Cenderello, Antonio Craxì, Filomena Morisco, Maurizia Rossana Brunetto, V.C. Di Maio, Vincenzo Sangiovanni, A. Ciancio, Piero Colombatto, Valeria Micheli, Teresa Pollicino, Laura Ambra Nicolini, Alessia Giorgini, Valeria Ghisetti, S. Novati, Annapaola Callegaro, Aldo Bertoli, E. Milano, Roberto Gulminetti, A. De Santis, F. Ceccherini-Silberstein, Teresa Santantonio, C. Masetti, G. Raimondo, Di Maio, V.C., Aragri, M., Masetti, C., Paolucci, S., Bruzzone, B., Degasperi, E., Barbaliscia, S., Pollicino, T., Minichini, C., Calvaruso, V., Rendina, M., Cento, V., Teti, E., Micheli, V., Ghisetti, V., Polilli, E., Palitti, V. Pace, Landonio, S., Lenci, I., Donnarumma, L., Nicolini, L.A., Bertoli, A., Starace, M., Pasquazzi, C., Callegaro, A.P., Morisco, F., Cenderello, G., Marenco, S., Gulminetti, R., Novati, S., Guarneri, V., Andreone, P., Galli, S., Ciancio, A., Sangiovanni, V., Cuomo, N., Raddi, A., Morsica, G., Borghi, V., Maida, I., Brunetto, M., Colombatto, P., Cozzolongo, R., De Santis, A., Lichtner, M., Babudieri, S., Taliani, G., Santantonio, T., Di Stefano, M., Paternoster, C., Ganga, R., Puoti, M., Rizzardini, G., Pellicelli, A., Milano, E., Mastroianni, C., Licata, A., Di Lorenzo, F., Giorgini, A., Lampertico, P., Parruti, G., Coppola, N., Zazzi, M., Raimondo, G., Andreoni, M., Craxì, A., Angelico, M., Perno, C.F., and Ceccherini-Silberstein, F.
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Resistance test ,medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,DAA failur ,Vironet C ,NS5A ,Regimen ,Internal medicine ,medicine ,retreatment ,business - Abstract
Previous article in issueNext article in issue Introduction: There is a limited documentation about the retreatment of patients failing a recommended NS5A-containing regimen in Italy. Materials & methods: Within the VIRONET-C network, 386 NS5A-failing patients infected with different HCV-genotypes (GT) (GT1a/1b/2a-c/3a-b-g-h/4a-d-n-o-v=93/124/19/112/38) were analyzed. Retreatment of 105 failures was investigated. HCV-resistance-test was performed by Sanger-sequencing. Results: Failures following seven different NS5A-containing regimens were studied: 3D/2D (paritaprevir/ombitasvir ± dasabuvir) ± ribavirin (N = 72/4), daclatasvir/ledipasvir/velpatasvir + sofosbuvir ± ribavirin (N = 105/131/20), grazoprevir/elbasvir ± ribavirin (N = 34), glecaprevir/pibrentasvir (N = 20). Notably, 18.1% of NS5A-failing patients did not show any resistance-associated-substitutions (RAS), while 81.9% showed at least one NS5A-RAS, with multiclass-resistance in 35.5%. NS5A-RAS were observed more frequently in glecaprevir/pibrentasvir failures (GT1a 83.3%: Y93H + Q30H/D or +H58D; GT3a: 83.3% Y93H + A30K/G or +L31I) compared to sofosbuvir/velpatasvir (GT1a 16.6%: Y93H + Q30H, p = 0.08; GT3a 20.0%: Y93H/N + A30K/T, p = 0.03). To date, 105 failures have started a retreatment: sofosbuvir/velpatasvir ± ribavirin (N = 30), sofosbuvir/velpatasvir/voxilaprevir ± ribavirin (N = 67), glecaprevir/pibrentasvir (N = 4), grazoprevir/elbasvir ± sofosbuvir + ribavirin (N = 3), 3D + sofosbuvir + ribavirin (N = 1). The majority of patients were cirrhotic (51.9%) and relapsers (87.5%). The prevalence of NS5A-RASs before retreatment was 80.9%, with multiclass-resistance 29.5%. Among patients completing post-retreatment follow-up, a sustained-viral-response at week 12 (SVR12) was observed in 26/33 (78.8%). SVR4 was documented in 49/56 (87.5%). SVR12 was 76.0% with sofosbuvir/velpatasvir ± ribavirin (N = 25). Differently, SVR12 was 100% with glecaprevir/pibrentasvir for 8/12/16 weeks (N = 3), grazoprevir/elbasvir ± sofosbuvir + ribavirin for 12/24 weeks (N = 3) or 3D + sofosbuvir + ribavirin for 24 weeks (N = 1), despite the presence of NS5A-RASs. Until now, 67 patients started sofosbuvir/velpatasvir/voxilaprevir ± ribavirin recommended-retreatment for 12 weeks. 54/67 (80.6%) showed at least one baseline NS5A-RAS, 23/67 (34.3%) multiple-NS5A-RASs, and 22/67 (32.8%) multiclass-resistance. Of 25 patients with available outcome, 96.0% had SVR4. Only 1 GT1b infected patient was non-responder, without RASs before retreatment. Conclusions: In this real-life setting, NS5A-RASs were frequently detected at failure, and multiclass-resistance was around 30%. Overall, SVR after resistance-test-guided retreatment was >95%, with the exception of the sofosbuvir/velpatasvir retreatment. Our results show how HCV resistance-test at failure may be useful to optimize retreatment strategies.
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- 2019
24. Optimal efficacy of interferon-free HCV retreatment after protease inhibitor failure in real life
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L. Lambiase, Anna Claudia Pellicelli, Gloria Taliani, Barbara Menzaghi, Stefania Paolucci, Giuliano Rizzardini, Valeria Cento, Cesare Sarrecchia, Marianna Aragri, Francesca Ceccherini-Silberstein, M. Melis, M. Andreoni, Stefano Novati, Carlo Magni, Silvia Barbaliscia, Ilaria Lenci, V.C. Di Maio, Martina Milana, Elisabetta Teti, Mario Angelico, Caterina Pasquazzi, Aldo Bertoli, M. Puoti, A. Pecchioli, Valeria Micheli, Margherita Macera, Sergio Babudieri, Dante Romagnoli, Valeria Ghisetti, Laura Ambra Nicolini, Elisa Biliotti, Y. Troshina, Carlo Federico Perno, Fausto Baldanti, Simona Marenco, Nicola Coppola, T. Ruggiero, Manuele Koci Siciliano, Stefano Bonora, Alessia Ciancio, Cento, V, Barbaliscia, S, Lenci, I, Ruggiero, T, Magni, C, Paolucci, S, Babudieri, S, Siciliano, M, Pasquazzi, C, Ciancio, A, Perno, C, Ceccherini-Silberstein, F, Micheli, V, Troshina, Y, Biliotti, E, Milana, M, Melis, M, Teti, E, Lambiase, L, Menzaghi, B, Nicolini, L, Marenco, S, Di Maio, V, Aragri, M, Pecchioli, A, Bertoli, A, Sarrecchia, C, Macera, M, Coppola, N, Puoti, M, Romagnoli, D, Pellicelli, A, Bonora, S, Novati, S, Baldanti, F, Ghisetti, V, Andreoni, M, Taliani, G, Rizzardini, G, Angelico, M, Barbaliscia, I, and Ceccherini Silberstein, F
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0301 basic medicine ,Male ,Cirrhosis ,Genotyping Techniques ,Sustained Virologic Response ,Hepacivirus ,Treatment failure ,chemistry.chemical_compound ,Liver disease ,0302 clinical medicine ,NS5A-inhibitors ,Genotypic resistance testing ,Treatment Failure ,Chronic ,HCV resistance ,biology ,Direct acting antivirals ,HCV failure ,Protease-inhibitors ,Retreatment ,Adult ,Aged ,Antiviral Agents ,Female ,Hepatitis C, Chronic ,Humans ,Microbial Sensitivity Tests ,Middle Aged ,Protease Inhibitors ,Sequence Analysis, DNA ,General Medicine ,Settore MED/07 - Microbiologia e Microbiologia Clinica ,Protease-inhibitor ,Hepatitis C ,humanities ,Infectious Diseases ,DIrect acting antivirals ,HCVFailure ,hcv-resistance ,030211 gastroenterology & hepatology ,Sequence Analysis ,Microbiology (medical) ,medicine.medical_specialty ,03 medical and health sciences ,Internal medicine ,medicine ,In real life ,Protease inhibitor (pharmacology) ,Cirrhosi ,business.industry ,Ribavirin ,DNA ,biology.organism_classification ,medicine.disease ,Surgery ,Regimen ,030104 developmental biology ,chemistry ,NS5A-inhibitor ,Direct acting antiviral ,business - Abstract
Objectives First-generation protease-inhibitors (PIs) have suboptimal efficacy in GT-1 patients with advanced liver disease, and patients experiencing treatment failure may require urgent retreatment. Our objective was to analyse the real-life efficacy of interferon (IFN)-free retreatment after PI-failure, and the role of genotypic-resistance-testing (GRT) in guiding retreatment choice. Methods In this multi-centre observational study, patients retreated with IFN-free regimens after first-generation PI-failure (telaprevir-boceprevir-simeprevir) were included. Sustained-virological-response (SVR) was evaluated at week 12 of follow-up. GRT was performed by population-sequencing. Results After PI-failure, 121 patients (cirrhotic = 86.8%) were retreated following three different strategies: A) with ‘GRT-guided’ regimens (N = 18); B) with ‘AASLD/EASL recommended, not GRT-guided’ regimens (N = 72); C) with ‘not recommended, not GRT-guided’ regimens (N = 31). Overall SVR rate was 91%, but all 18 patients treated with ‘GRT-guided’ regimens reached SVR (100%), despite heterogeneity in treatment duration, use of PI and ribavirin, versus 68/72 patients (94.4%) receiving ‘AASLD/EASL recommended, not GRT-guided’ regimens. SVR was strongly reduced (77.4%) among the 31 patients who received a ‘not recommended, not GRT-guided regimen’ (p
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- 2017
25. Comparison of resistance profiles among DAA-naive and DAA-experienced patients infected with HCV non-1 genotype in Italy
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Simona Francioso, A. Ciaccio, Teresa Pollicino, Bianca Bruzzone, G. Fiorentino, V. Boccaccio, Coppola Nicola, M. Puoti, Ivana Maida, Valeria Cento, Lucio Boglione, Francesca Ceccherini Silberstein, Valeria Micheli, Silvia Barbaliscia, Sergio Babudieri, Guido Gubertini, Giustino Parruti, Antonio Craxì, Vincenzo Vullo, Ennio Polilli, M. Andreoni, Filomena Morisco, Vincenzo Sangiovanni, Vincenza Calvaruso, Renato Maserati, Velia Chiara Di Maio, Maurizio Zazzi, Marianna Aragri, A. Ciancio, Barbara Rossetti, Anna Claudia Pellicelli, Elisabetta Teti, C.F. Perno, Caterina Pasquazzi, L. Sarmati, R. D’Ambrosio, Mario Angelico, Fosca Niero, Stefano Bonora, M. Rendina, Gloria Taliani, Luca Foroghi, Laura Ambra Nicolini, Aldo Bertoli, A. Lleo, G. Raimondo, T. Ruggiero, Simona Marenco, Valeria Pace Palitti, G.B. Gaeta, Stefania Paolucci, and Ilaria Lenci
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Hepatology ,Resistance (ecology) ,business.industry ,Genotype ,Medicine ,business ,Virology - Published
- 2018
26. Antiviral therapy can prevent in HCV infected patients relapse of diffuse large B cell lymphoma
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Anna Claudia Pellicelli, Giuseppe Maria Ettorre, V. Pellicelli, R. Villani, Valerio Giannelli, Anna Linda Zignego, and Valerio Zoli
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Hepatology ,business.industry ,Cancer research ,Antiviral therapy ,Medicine ,business ,medicine.disease ,Diffuse large B-cell lymphoma - Published
- 2018
27. Characterization of resistance profiles in HCV 2-3-4 DAA-naïve and DAA-experienced infected patients in Italy
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V. Boccaccio, Irene Maida, Ennio Polilli, Alessandro Ciaccio, Ilaria Lenci, Anna Claudia Pellicelli, Marilena Rendina, Fabio Niero, Guido Gubertini, Mario Angelico, T. Ruggiero, Stefano Bonora, Barbara Rossetti, Caterina Pasquazzi, Niccolò Gabriele Coppola, Simona Francioso, Silvia Barbaliscia, M. Puoti, M. Andreoni, L. Foroghi, L. Sarmati, Silvia Paolucci, Giuliana Fiorentino, Teresa Pollicino, G.B. Gaeta, C.F. Perno, Giustino Parruti, Valeria Cento, Laura Ambra Nicolini, Gloria Taliani, Elisabetta Teti, Lucio Boglione, Asia Bertoli, Sergio Babudieri, Valeria Micheli, Renato Maserati, Marianna Aragri, F. Ceccherini-Silberstein, Vincenzo Vullo, A. R. D’Ambrosio, Simona Marenco, A. Lleo, Antonio Craxì, Filomena Morisco, V.C. Di Maio, Vincenzo Sangiovanni, Maurizio Zazzi, Vincenza Calvaruso, Alessia Ciancio, V. Pace Palitti, Bianca Bruzzone, and Giacomo Raimondo
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Hepatology ,business.industry ,Gastroenterology ,Medicine ,business ,Virology - Published
- 2018
28. VIROLOGICAL FAILURES TO NEW DIRECT ACTING ANTIVIRALS IN A REAL LIFE SETTING MAY REQUIRE UNCONVENTIONAL REGIMENS FOR RE-TREATMENT
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Manuela Merli, M. Paoloni, Gabriella Verucchi, Simona Francioso, M. Melis, Vincenza Calvaruso, Caterina Pasquazzi, Marianna Aragri, F.P. Antonucci, Dante Romagnoli, Sergio Babudieri, G.B. Gaeta, M. Puoti, Ilaria Lenci, V. Pisani, Francesco Donato, Marco Biolato, Valeria Cento, D. Di Paolo, C.F. Perno, Mario Angelico, F. Ceccherini-Silberstein, Anna Claudia Pellicelli, Antonio Craxì, Filomena Morisco, V.C. Di Maio, Jacopo Vecchiet, Stefano Brillanti, Aldo Bertoli, Di Maio, VC, Cento, V, Di Paolo, D, Lenci, I, Aragri, M, Verucchi, G, Melis, M, Bertoli, A, Antonucci, FP, Francioso, S, Pellicelli, A, Calvaruso, V, Pasquazzi, C, Romagnoli, D, Biolato, M, Vecchiet, J, Morisco, F, Merli, M, Gaeta, GB, Brillanti, S, Donato, F, Puoti, M, Pisani, V, Paoloni, M, Babudieri, S, Craxi, A, Angelico, M, Perno, CF, and Ceccherini-Silberstein, F
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medicine.medical_specialty ,Hepatology ,business.industry ,DIRECT ACTING ANTIVIRALS ,Real life setting ,RAS, RAVS, RAV, HCV, DAA, THERAPY ,RAVS ,THERAPY ,RAS ,RAV ,HCV ,DAA ,03 medical and health sciences ,0302 clinical medicine ,medicine ,030211 gastroenterology & hepatology ,030212 general & internal medicine ,Intensive care medicine ,business - Published
- 2016
29. Multiclass HCV resistance to interferon-free direct acting antivirals regimens in real life failures advocates for tailored second-line therapies
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Ilaria Lenci, A. Di Biagio, Giuliano Rizzardini, L. Marinaro, C. D'Ambrosio, Fausto Baldanti, Ivana Maida, G.B. Gaeta, M. Puoti, T. Ruggiero, Mario Angelico, Vincenza Calvaruso, Laura Sticchi, Mario Starace, Giustino Parruti, P. Cacciatore, Nicola Caporaso, Caterina Pasquazzi, Stefania Paolucci, Anna Claudia Pellicelli, M. Andreoni, C. Masetti, Sergio Babudieri, Gabriella d'Ettorre, Francesco Santopaolo, Raffaele Cozzolongo, P. Andreone, Carlo Magni, Valeria Cento, Guido Gubertini, J. Vecchiet, Stefano Novati, Nicola Coppola, C.F. Perno, Bianca Bruzzone, F. De Leonardis, V. Pace Palitti, Marianna Aragri, A. Grieco, Pierluigi Tarquini, G. De Stefano, G. Raimondo, Teresa Pollicino, Alessia Giorgini, Giorgio Barbarini, Valeria Ghisetti, G. Verucchi, M.C. Sorbo, Savino Bruno, M. Paoloni, F. Ceccherini-Silberstein, Roberto Gulminetti, Antonio Craxì, Filomena Morisco, Manuela Merli, V.C. Di Maio, Vincenzo Sangiovanni, A. Ciancio, Simona Francioso, Simona Landonio, Aldo Bertoli, A. Mancon, Valeria Micheli, Antonio Picciotto, V. Boccaccio, M. Melis, Ennio Polilli, F.P. Antonucci, Dante Romagnoli, and Silvia Barbaliscia
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Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,Interferon free ,Gastroenterology ,DIRECT ACTING ANTIVIRALS ,03 medical and health sciences ,0302 clinical medicine ,Second line ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,In real life ,030211 gastroenterology & hepatology ,business - Published
- 2017
30. The challenge of HCV-retreatment after DAA-failure: real-life experience advocates for caution
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Vincenza Calvaruso, C. Masetti, Silvia Barbaliscia, Bianca Bruzzone, Giustino Parruti, Sergio Babudieri, Marco Biolato, Marianna Aragri, C.F. Perno, Vincenzo Messina, Valeria Cento, Simona Landonio, M. Melis, Carmine Minichini, Valeria Micheli, F. Ceccherini-Silberstein, Lucio Boglione, Giorgio Barbarini, Mario Angelico, Aldo Bertoli, Monica Schiavini, Laura Ambra Nicolini, Ennio Polilli, Raffaele Cozzolongo, Carlo Magni, Chiara Baiguera, C. Dentone, Giuliano Rizzardini, Anna Claudia Pellicelli, M. Siciliano, Y. Troshina, Antonio Craxì, Filomena Morisco, M. Puoti, V.C. Di Maio, A. Ciancio, Ilaria Lenci, Laura Sticchi, Stefania Paolucci, T. Ruggiero, Simona Marenco, and Nicola Coppola
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0301 basic medicine ,03 medical and health sciences ,medicine.medical_specialty ,030104 developmental biology ,0302 clinical medicine ,Hepatology ,business.industry ,Immunology ,medicine ,030211 gastroenterology & hepatology ,Intensive care medicine ,business - Published
- 2017
31. Multiclass hepatitis C virus resistance to direct acting antivirals in real life interferon-free regimens failures advocates for tailored second-line therapies
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A. Grieco, Valeria Cento, Savino Bruno, M. Paoloni, Anna Claudia Pellicelli, Gabriella d'Ettorre, Raffaele Cozzolongo, G.D. Stefano, Carlo Magni, V. Boccaccio, M. Andreoni, Fausto Baldanti, Silvia Barbaliscia, J. Vecchiet, Valeria Micheli, Antonio Picciotto, Giustino Parruti, Guido Gubertini, M. Melis, Pierluigi Tarquini, Francesca Ceccherini-Silberstein, Bianca Bruzzone, Sergio Babudieri, Antonio Di Biagio, M. Puoti, Manuela Merli, L. Marinaro, Mario Starace, Caterina Pasquazzi, Marianna Aragri, Antonio Craxì, Teresa Pollicino, Filomena Morisco, V.C. Di Maio, Alessia Giorgini, Vincenzo Sangiovanni, Giorgio Barbarini, Valeria Ghisetti, G. Verucchi, T. Ruggiero, Ivana Maida, P. Andreone, Vincenza Calvaruso, Giovanni Raimondo, C. D'Ambrosio, Simona Francioso, F.P. Antonucci, Dante Romagnoli, C.F. Perno, Mario Angelico, Ilaria Lenci, Alessia Ciancio, Roberto Gulminetti, G.B. Gaeta, Simona Landonio, Nicola Caporaso, Francesco Santopaolo, Nicola Coppola, Laura Sticchi, Valeria Pace Palitti, Stefania Paolucci, Aldo Bertoli, and A. Mancon
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0301 basic medicine ,Hepatology ,business.industry ,Hepatitis C virus ,Interferon free ,medicine.disease_cause ,DIRECT ACTING ANTIVIRALS ,Virology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Second line ,medicine ,In real life ,030211 gastroenterology & hepatology ,business - Published
- 2017
32. Innovation and social responsibility in food ingredients market
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Stefaan Van Dyck, Anna Claudia Pellicelli, and Luigi Bollani
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multivariate statistical analysis ,Economics and Econometrics ,Public economics ,Risk aversion ,Empirical survey ,risk aversion ,social responsibility ,consumer behaviour ,food ingredients market, innovation, risk aversion, social responsibility, consumer behaviour, empirical survey, multivariate statistical analysis ,innovation ,empirical survey ,food ingredients market ,Business ,Business and International Management ,Social responsibility ,Consumer behaviour - Abstract
This paper deals with food ingredients market. It describes some international characteristics and trends focusing on the importance of innovation to assure continuity to the business preserving the respect of environment. Particularly the social responsibility of the market companies may produce improvements in B2C, but also in B2B channels. An entrepreneurial vision is presented as a necessary link with theoretical backgrounds. An empirical analysis is also introduced to validate some conclusions.
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- 2018
33. Treatment failure to first-line direct antiviral (DAA) in HCV-related advanced liver disease: An Italian real-life urban setting
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C.F. Perno, F. Chiesara, D. Di Paolo, V. Gerardi, Alessandra Moretti, Francesca Ceccherini-Silberstein, Anna Claudia Pellicelli, Valeria Cento, C. Masetti, Paolo Rossi, Francesco Santopaolo, M. Siciliano, Mario Angelico, L. Fondacaro, Martina Milana, Raffaella Lionetti, Ilaria Lenci, and Gianpiero D’Offizi
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Liver disease ,medicine.medical_specialty ,Hepatology ,business.industry ,First line ,Internal medicine ,Gastroenterology ,medicine ,medicine.disease ,business ,Virology ,Treatment failure - Published
- 2016
34. Clinical relevance of accurate HCV genotype and subtype assignment by NS3/NS5A/NS5B direct sequencing in the era of new direct acting antiviral agents
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Carlo Magni, Francesca Ceccherini-Silberstein, M. Puoti, Claudio Maria Mastroianni, A. Di Biagio, Marco Romano, Filomena Morisco, Giustino Parruti, Antonio Gasbarrini, Gloria Taliani, M. Siciliano, Simona Landonio, V.C. Di Maio, Martina Milana, Laura Gianserra, F. Deodati, Caterina Pasquazzi, M. Andreoni, J. Vecchiet, Valeria Cento, L. Lambiase, Marianna Aragri, Simona Francioso, E. D’Amico, Gabriella d'Ettorre, Giuliano Rizzardini, D. Di Paolo, Antonio Grieco, F. De Leonardis, A. Manunta, Ivana Maida, Anna Claudia Pellicelli, Mario Angelico, K. Yu La Rosa, Miriam Lichtner, P. Cacciatore, Cesare Sarrecchia, F.P. Antonucci, Aldo Bertoli, Valeria Micheli, Antonio Picciotto, Dante Romagnoli, Savino Bruno, Laura Ambra Nicolini, Ilaria Lenci, C.F. Perno, Marco Ciotti, Lorenzo Nosotti, Simona Marenco, Elisabetta Teti, M. Tontodonati, Maria Stella Mura, R. Campoli, Nicola Caporaso, S. Grieco, Sergio Babudieri, and Umberto Vespasiani-Gentilucci
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Genetics ,chemistry.chemical_compound ,NS3 ,Hepatology ,chemistry ,Direct sequencing ,Genotype ,Gastroenterology ,Clinical significance ,Biology ,NS5A ,NS5B ,Direct acting - Published
- 2016
35. Presence of resistance associated variants in patients with virological failure to new direct acting antivirals and requirement of unconventional regimens for re-treatment
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Antonio Craxì, Filomena Morisco, M. Puoti, V.C. Di Maio, Nicola Caporaso, Anna Claudia Pellicelli, Francesca Ceccherini-Silberstein, M. Paoloni, Maria Stella Mura, G.B. Gaeta, F.P. Antonucci, Vincenza Calvaruso, R. Campoli, Gianluca Brancaccio, D. Di Paolo, Dante Romagnoli, Antonio Grieco, K. Yu La Rosa, Stefano Brillanti, Valeria Cento, Caterina Pasquazzi, Ilaria Lenci, Manuela Merli, Simona Francioso, M.C. Sorbo, M. Melis, Marco Biolato, C.F. Perno, Marianna Aragri, Aldo Bertoli, Gabriella Verucchi, Sergio Babudieri, V. Pisani, Mario Angelico, Francesca Donato, and J. Vecchiet
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Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,DIRECT ACTING ANTIVIRALS ,Virological failure ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,030211 gastroenterology & hepatology ,In patient ,business - Published
- 2016
36. Natural HCV resistance is common in Italy and differently associated to genotypes
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Simona Landonio, Barbara Menzaghi, Giustino Parruti, T. Ruggiero, Valeria Cento, Francesca Ceccherini-Silberstein, Ilaria Lenci, M. Melis, Giuliano Rizzardini, Antonio Gasbarrini, P. Cacciatore, V. Pace Palitti, M.C. Sorbo, Ennio Polilli, Martina Milana, Alessandro Pieri, Laura Gianserra, Anna Claudia Pellicelli, P. Andreone, C. Masetti, Bianca Bruzzone, Simona Marenco, Elisabetta Teti, M. Andreoni, Gloria Taliani, Aldo Bertoli, Elisa Biliotti, Miriam Lichtner, Nicola Coppola, Vincenza Calvaruso, Fausto Baldanti, Stefania Paolucci, C.F. Perno, Carlo Magni, Sergio Babudieri, Valeria Micheli, Antonio Craxì, Filomena Morisco, V.C. Di Maio, Dante Romagnoli, Laura Ambra Nicolini, Mario Angelico, Loredana Sarmati, M. Siciliano, M. Puoti, N. Iapadre, Marianna Aragri, Vincenzo Vullo, Caterina Pasquazzi, and F. De Leonardis
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0301 basic medicine ,Genetics ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Hepatology ,Resistance (ecology) ,business.industry ,Genotype ,Gastroenterology ,Medicine ,030211 gastroenterology & hepatology ,business - Published
- 2017
37. Daclatasvir/sofosbuvir and ribavirin 800mg flat dose is highly efficacy and safe in genotype 3 compensated and decompensated cirrhotic patients: The CLEO experience
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F. Ceccherini Silberstein, G. Cerasari, C.F. Perno, A. Moretti, L. Fondacaro, Giorgio Barbarini, F. Chiesara, Anna Claudia Pellicelli, R. Villani, C. D'Ambrosio, F.R. Ponziani, Sergio Babudieri, Maurizio Pompili, Rodolfo Sacco, Roberto Gulminetti, Pierluigi Tarquini, V. Pace Palitti, Vincenzo Messina, Antonio Izzi, V.C. Di Maio, F. Di Candilo, Valerio Giannelli, Vincenzo Iovinella, and Serena Dell'Isola
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medicine.medical_specialty ,Hepatology ,Sofosbuvir ,business.industry ,Ribavirin ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,030220 oncology & carcinogenesis ,Internal medicine ,Genotype ,medicine ,030211 gastroenterology & hepatology ,business ,medicine.drug - Published
- 2017
38. Innovation Policy and Environmental Sustainability as Strategic Tools for Reaching Higher Performances A Regional Empirical Analysis to Find the Best Practice
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Anna Claudia Pellicelli, Cecilia Giuliana Casalegno, Michela Pellicelli, and Chiara Civera
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Entrepreneurship ,Sociology and Political Science ,business.industry ,Best practice ,Geography, Planning and Development ,Social sustainability ,Environmental resource management ,SMEs ,Management, Monitoring, Policy and Law ,Environmental Science (miscellaneous) ,innovation ,Order (exchange) ,Sustainability ,Corporate social responsibility ,corporate social sustainability ,Business ,Sustainability organizations ,Small and medium-sized enterprises ,Industrial organization - Abstract
Despite the sector or the company’s size, the choice of the strategies is worth; it is about a set of different aspects included by firms into their own strategic and operating procedures. The general aim of this study is to analyse how Italian Small and Medium Enterprises (SMEs) are tackling the challenges by adopting more responsible and sustainable strategies and tools in order to create social and economic value and to compete successfully. Moreover, the paper is focused on setting up a rulebook for family business SMEs in which are specified suggestions about overcoming the crisis and achieving the success.
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- 2014
39. Failure to First-Line Direct Antiviral (DAA) Treatment of HCV Infection in an Italian Real-Life Urban Setting
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C. Masetti, F. Ceccherini-Silberstain, L. Fondacaro, Francesco Santopaolo, Gianpiero D’Offizi, D. Di Paolo, Valeria Cento, A. Moretti, Ilaria Lenci, Raffaella Lionetti, Mario Angelico, Anna Claudia Pellicelli, Martina Milana, Plinio Rossi, C.F. Perno, F. Chiesara, Annalisa Tortora, and M. Siciliano
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Hepatology ,business.industry ,First line ,Medicine ,business ,Virology - Published
- 2016
40. P1235 BASELINE/EARLY PRESENCE OF KNOWN AND NOVEL RESISTANCE MUTATIONS IS ASSOCIATED WITH VIRAL FAILURE IN DIFFICULT-TO-TREAT PATIENTS TREATED WITH FIRST GENERATION PROTEASE INHIBITORS
- Author
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C.F. Perno, Alessandro Gasbarrini, Marianna Aragri, J. Vecchiet, M. Andreoni, Carlo Magni, Ilaria Lenci, Valeria Cento, F.P. Antonucci, Daniele Armenia, Simona Landonio, Laura Ambra Nicolini, D. Di Paolo, M. Siciliano, M. Tontodonati, Giustino Parruti, Maria Concetta Bellocchi, Sergio Babudieri, Anna Claudia Pellicelli, Mario Angelico, Maria Stella Mura, Giuliano Rizzardini, Cesare Sarrecchia, F. De Leonardis, Gloria Taliani, F. Ceccherini-Silberstein, V.C. Di Maio, Alessandro Mancon, A. Di Biagio, Lorenzo Nosotti, Valeria Micheli, and A. Manunta
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Protease ,Hepatology ,business.industry ,medicine.medical_treatment ,medicine ,Baseline (configuration management) ,business ,Virology ,First generation - Published
- 2014
41. Early viral dynamics in HCV-RNA decay and NS3-resistance development predict the risk of failure to first-generation protease inhibitors
- Author
-
Giustino Parruti, Gloria Taliani, Simona Francioso, Ilaria Lenci, F.P. Antonucci, Claudio Maria Mastroianni, Simona Landonio, Laura Ambra Nicolini, Ivana Maida, Valeria Micheli, Antonio Picciotto, D. Di Paolo, Giuliano Rizzardini, Lorenzo Nosotti, F. De Leonardis, Marco Massari, Antonio Gasbarrini, Anna Claudia Pellicelli, Sergio Babudieri, A. Manunta, Jacopo Vecchiet, Francesca Ceccherini-Silberstein, M. Tontodonati, A. De Maria, Ennio Polilli, Maria Stella Mura, Tamara Ursini, Cesare Sarrecchia, Simona Marenco, A. Di Biagio, Marianna Aragri, Massimo Andreoni, Mario Angelico, Valeria Cento, Fosca Niero, Alessandra Mangia, Annalisa Tortora, Alessandro Mancon, M. Siciliano, V.C. Di Maio, Carlo Federico Perno, Carlo Magni, Claudio Viscoli, and Aldo Bertoli
- Subjects
NS3 ,Protease ,Hepatology ,Resistance development ,Viral dynamics ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Medicine ,business ,Virology ,First generation - Published
- 2014
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