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Abstract The modular multilevel converter (MMC) based high voltage DC (HVDC) system can be effectively used for bulk power transmission. The MMC topology for the voltage source converter (VSC) has several advantages. In this work, the transformerless operation of MMC is explored. The internal dynamic of MMC can induce a third‐order zero‐sequence harmonic current. Its effect on the system is analysed, including the adverse impacts on energy requirement per arm and power transfer capability. The internal dynamic equations of the transformerless MMC configuration are derived, and two different controllers: the proportional‐resonant (PR) controller and proportional‐integral (PI) controller, were applied to suppress the unwanted third‐order current. The performance analysis of these controllers is presented and the results indicate that the controllers efficiently suppress the third‐order harmonic current. Moreover, the electromagnetic transient (EMT) models of MMC under different configurations have been developed on the real‐time digital simulator (RTDS) platform. An analysis of internal variables of the MMC is also included to ensure that the controller does not adversely affect the system. Lastly, the state‐space model is developed, and the stability is analysed.

Purpose – The purpose of this paper is to study the geometry of screen real lightlike submanifolds of metallic semi-Riemannian manifolds. Also, the authors investigate whether these submanifolds are warped product lightlike submanifolds or not. Design/methodology/approach – The paper is design as follows: In Section 3, the authors introduce screen-real lightlike submanifold of metallic semi Riemannian manifold. In Section 4, the sufficient conditions for the radical and screen distribution of screen-real lightlike submanifolds, to be integrable and to be have totally geodesic foliation, have been established. Furthermore, the authors investigate whether these submanifolds can be written in the form of warped product lightlike submanifolds or not. Findings – The geometry of the screen-real lightlike submanifolds has been studied. Also various results have been established. It has been proved that there does not exist any class of irrotational screen-real r-lightlike submanifold such that it can be written in the form of warped product lightlike submanifolds. Originality/value – All results are novel and contribute to further study on lightlike submanifolds of metallic semi-Riemannian manifolds.

Various emerging and remerging zoonotic infectious diseases are seen as a threat to manifest in a pandemic. The current study was planned to assess the environmental vulnerability or preparedness for Scrub typhus and disease due to Nipah and Zika virus infection in the Faridabad district. A Cross-sectional study was conducted in 2021 through 2022 in a rural and an urban area in the Faridabad district of Haryana, India. Houses of the study area were the study unit for internal environment risk assessment. The important landmarks which are frequently visited by the residents of the community were the study unit for external environment assessment. A sample size of 192 was calculated by scientific methods, and systematic random sampling was used. A predesigned checklist for the assessment of risk factors in the environment was used. Data were analyzed using Epi info version 7. Twelve external sites were studied in urban and nine in the rural areas. Stagnant water in external sites as a potential source of breeding for the Zika virus vector (Aedes mosquito) was present in 16.7% of rural and 57.1% of urban areas. Potential dwelling sites for bats (the carriers of Nipah virus) were observed in 66.7% and 42.9% of rural and urban sites, respectively. The garbage dump was observed in the internal environment of 58.8% urban and 15.2% of rural households. Rats (one of the hosts of mites) have been reported in more than 80% of urban and rural households. Low lying shrubs (which carry vector mites of Scrub typhus) were present only in rural areas. No cases of all three diseases has been reported in this district. The study reported that the environment was susceptible to Zika virus and Scrub typhus agents. The behavior of the people was more susceptible to Zika virus disease.

Beta-carboline is an indole alkaloid which has been identified as a valuable heterocyclic nucleus in the field of medicinal chemistry. It has different biological activities like antibacterial, anticancer, antifungal, antimalarial, antileishmanial, anti-HIV, anti-trypanosomal, and anti-toxoplosmal respectively in various medicinal compounds. The study of various potent beta-carboline derivatives and their synthetic aspects helps to design other potent derivatives for the effective treatment of multiple diseases like leishmaniasis, malaria, cancer, AIDS, tuberculosis, and bacterial and fungal infections. Incorporation of beta-carboline nucleus improves physiochemical and pharmacological properties. This review is mainly focused on various potential pharmacological active beta-carboline derivatives developed in the last twenty years with their synthetic aspects and structure activity relationship. It is helpful to synthetic chemists, drug designers, and medicinal chemists to design target-based new beta-carboline derivatives with good pharmacological activities in the future.

Abstract Currently, the modular multilevel converter (MMC) is the most advanced voltage source converter topology. Because the MMC is a converter topology, the most common approach for controller design is considering the conventional converter model to design the controller accordingly. Though this approach ignores the internal dynamics of the MMC, the modular structure enables distribution of the capacitors in six arms of the MMC. However, this distribution leads to a complex internal dynamic that affects the controller operation and cannot be disregarded. In this study, a detailed fundamental and circulating current model of the MMC is developed while considering its internal dynamics. The detailed modelling reveals cross‐ and inter‐couplings. On the basis of the detailed model and analysis of the couplings, three controllers have been proposed. Moreover, the performances of the proposed and conventional controllers have been analysed and compared under steady‐state and active and reactive power changes. The proposed controllers are observed to achieve improved decoupling compared to that achieved by the conventional controller.

The reproductive success of a male is limited by the number of females it can mate with. Thus, males deploy elaborate strategies to maximize access to females. In Nasonia, which are parasitoids of cyclorrhaphous flies, such reproductive strategies are thought to be restricted to competition among males for access to females in the natal patch. This study investigates whether additional strategies are present, especially the capability to identify which fly hosts contain adult females inside. Behavioural assays revealed that only one out of the four species, N. vitripennis, can distinguish which hosts specifically have adult female wasps, indicating a species-specific reproductive strategy. Results of gas chromatography-mass spectrometry analyses and behavioural data suggest that female-signature cuticular hydrocarbons (CHCs) are used as chemical cues, possibly emanating from within the host puparium. Further assays indicated that N. vitripennis males can also detect differences in the intensities of female-signature CHCs, giving them the capability to seek out hosts with maximum number of females. This study uncovers a previously unknown reproductive strategy in one of the most widely studied parasitoid wasps.

Aim: The present study was conducted for the evaluation of Interleukin (IL)-1b levels in human gingival crevicular fluid (GCF), intensity of pain, and the amount of tooth movement measured during canine retraction using different magnitudes of continuous orthodontic force. Materials and Method: A statistically significant number of subjects were included for the study (n = 16, 6 male subjects and 10 female subjects). The age ranged from 18 to 24 years and all were diagnosed with Class I bimaxillary protrusion. They underwent first premolar extractions prior to participating in the study. The maxillary cuspids were then retracted using a continuous force of either 50 or 150 g. This was executed using nickel–titanium coil springs on segmented archwires. The opposite counterpart, that is, mandibular cuspid was used as control. GCF was then drawn from the distal aspect of each tooth at defined time intervals. This was followed by the assessment of IL-1b concentrations, pain intensity, using the visual analogue scale (VAS), and the amount of tooth movement. ANOVA test, Friedman test, and paired t-tests were used for comparisons of IL-1b in GCF, the plaque and gingival indices, and the efficiency of tooth movement on pain perception, respectively. Results: The 150 g group showed the highest level of IL-1b concentration at 24 h from baseline and at 2 with significant differences compared with the control group (P < 0.05). The mean VAS score of pain intensity from the 150 g force was significantly greater than from the 50 g force at 24 h (P < 0.01). Conclusion: No significant difference in the amount of tooth movement was found between these two different magnitudes of continuous force at 2 months. A 50 g force could effectively induce tooth movement similar to 150 g with less pain and less inflammation.

OBJECTIVE: This study aimed to assess the feasibility of reusing nickel–titanium (NiTi) alloy wires after 6 weeks of intraoral use by evaluating the changes in the load-deflection properties and surface characterization of these alloy wires after cold sterilization by immersion in 2% of acidic glutaraldehyde for 10 h. MATERIAL AND METHODS: Twenty wires each in three groups of G1-as-received wires (ARW), G2-unsterilized used wires, and G3-sterilized used wires (SUW) were tested by the three-point bending test and scanning electron microscopy (SEM). The data were subjected to statistics, one-way analysis of variance, and Bonferroni posthoc test for comparison. RESULTS: Recycling of NiTi wires produced statistically insignificant changes in both the loading and unloading properties of the wires. The forces needed to twist the used wires, that is, G2-(UUW) and G3-(SUW) were lower than G1-(ARW), suggesting lowering of the stiffness of the wires. Superelasticity is well-maintained by G2-(UUW) and G3-(SUW) although there is an insignificant lowering of the forces exerted by them during loading and unloading. SEM demonstrated no increase in the pitting of surfaces in both G2-(UUW) and G3-(SUW); multiple areas were seen to be more smoothened over G2-(UUW) and G3-(SUW) NiTi wires surfaces. CONCLUSION: The findings of this study support the reuse of NiTi wires after 6 weeks of use in oral conditions followed by cold sterilization by immersion in 2% acidic glutaraldehyde for 10 h.

Musculoskeletal problems have become a significant issue in the profession of dentistry. There are currently no recommended effective disease-preventing and modifying remedies. High prevalence rates for musculoskeletal disorders (MSDs) among dentists have been reported in the literature. Complementary and alternative medicine can be helpful in managing and preventing the MSDs. The purpose of this study was to determine if dentists in the western part of India are using complementary and alternative medicine therapies for MSDs, and also to find if those who use complementary and alternative medicine therapies have greater job/career satisfaction compared to conventional therapy (CT) users. Dentists of western India registered under the Dental Council of India (N=2166) were recruited for the study. Data were analyzed using univariate and bivariate analyses and logistic regression. A response rate of 73% (n=1581) was obtained, of which 79% (n=1249) was suffering from MSDs. The use of complementary and alternative medicine or CT was reported by 90% (n=1124) of dentists with MSDs. Dentists using complementary and alternative medicine reported greater health (P

Background: Musculoskeletal disorders have serious impact on the profession of dentistry. There is common occurrence of pain due to incorrect posture in dental professionals. Complementary and alternative medicine (CAM) therapies may cast a new light on preventing and intercepting musculoskeletal disorders (MSD). An epidemiological study was conducted in an effort to contribute to the prevention of musculoskeletal disorders in dentistry. The purpose of this study was to determine the prevalence of MSD at dentists using CAM as a treatment and preventive modality for MSD and to compare job/career satisfaction between dentists who use CAM and conventional therapy (CT). Material and Methods: Dentists registered in Uttrakhand state, India, under the Dental Council of India and registered members of the Indian Dental Association, Uttrakhand branch (N = 1496) were surveyed. Statistical analysis was conducted using SPSS 17. Results: A response rate of 84% (N = 1257) was obtained, revealing that 90% (N = 1131) had the problem of MSD. Seventy three percentage (N = 826) of dentists with MSD reported the use of CAM and CT. Complementary and alternative medicine users reported greater overall health (72.7% vs. 51%, p < 0.001), job satisfaction (61.2% vs. 35%, p < 0.001) and work efficiency compared to CT users. Conclusions: Complementary and alternative medicine therapies may improve quality of life, reduce work interruption and enhance job satisfaction for dentists who suffers from MSD. Through the course of their studies, dentists should be equipped with knowledge on ergonomics and CAM therapies, such as yoga and others, to help them prevent musculoskeletal disorders more effectively. Med Pr 2014;65(3):317–323

The global apprehension regarding the ubiquitous presence of microplastics (MPs) and their associated health risks underscore a significant challenge. However, our understanding on the occurrence and characteristics of this emerging class of pollutants in the different environmental compartments remains limited. For instance, despite housing approximately 20-25% of the global population, the evidence of the atmospheric MPs in Indian Subcontinent is exceedingly rare. Hence, we for the first-time present data on the depositional flux, chemical composition, morphological features of the atmospheric MPs collected from the foothills of Indian Himalayas. The total number of MPs for the collected samples ranged from 65 to 752 particles, with an average of 317 ± 171 particles count. The average flux of atmospheric MPs was 2256 ± 1221 particles/m 2 /day and varied significantly from 462 particles/m 2 /day to 5346 particles/m 2 /day. The highest deposition (5346 particles/m 2 /day) of atmospheric MPs was recorded during the 3rd week of sampling, coinciding with the Diwali festival. Based on the visual characteristics, we determined that the size of MPs ranged from 67 to 2320 μm, with a predominant presence of smaller particles (<1200 μm), primarily composed of fragments and films/sheets. Raman spectroscopy indicated that the analyzed MPs were mainly composed of 4 different polymer types, including PE (46.8 ± 7.2 %), PP (20.9 ± 7.4 %), PS (15.6 ± 3.8 %) and PET (16.7 ± 9.9 %). We further highlighted the extent to which climate variables control the deposition of atmospheric MPs in this urban conglomerate located in the foothills of Himalayas. Our Lagrangian parcel tracking approach showed that the greater frequencies are of local origin and clustered near to the studied region. We also speculate that atmospheric microplastics can be transported along the westerly winds. Though we did not observe any significant relation (p > 0.05) between meteorological parameters and the quantity of atmospheric MPs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Lake systems respond physically, chemically, and biologically to hydro-climatic change and variability, and these responses are documented in the sediments. Individual proxies and lacustrine environments may respond to climate variations in a nonlinear way, making it difficult to determine the direction and extent of a climatic shift. Here we investigate the response of lake ecosystem to climatic and environmental changes using a suite of paleo-proxies including ostracods, chironomids, and n-alkanes distribution from paleolake 'Gayal el Bazal (Yemen)'. A previous study from this site has provided a continuous, and high-resolution dataset providing an understanding of precipitation during the last ca 1200 years, particularly during Medieval Climate Anomaly (MCA) and Little Ice Age (LIA). However, the response of the lake ecosystem to these changing hydro-climate conditions, including water-level, salinity, and productivity, remains unknown. The n-alkanes dataset shows that during pluvial interval such as the MCA, the lake experienced an increase in nutrient input resulting in enhanced aquatic productivity. Concurrently, ostracods assemblage displays an increased abundance of swimmer species (like Bradleytriebella lineata and Fabaeomiscandona cf. breuili), suggesting an indirect response between ostracods and climate shifts. The chironomid community during the MCA interval is dominated by taxa belonging to the subfamilies of Chironomini, suggesting a warm, shallow, productive environment with macrophyte vegetation. The LIA interval is marked by increased abundance of higher-chain length n-alkanes, suggesting increased contribution from higher plants. Furthermore, ostracod distribution revealed increased abundance of non-swimmer species like Vestalenula cylindrica., which thrive under saline conditions in the lake. Changes in abundances of Tanytarsini during the LIA interval, which are associated with higher oxygen levels, suggest changes in lake productivity. As a result, the overall patterns in biological indicators reveal that their individual abundance and species/tribe distribution fluctuates in response to changes in the climate and hydrological conditions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)

The present study provides baseline information on the concentration levels, distribution characteristics and pollution sources of environmental contaminants, such as phthalic acid esters (PAEs or phthalates) and petroleum hydrocarbons in surface sediments of the tropical estuaries (Mandovi and Ashtamudi) from western Peninsular India. Total PAEs (∑ 5 PAEs), hopanes, steranes and diasteranes concentrations from Ashtamudi estuary ranged from 7.77 to 1478.2 ng/g, n.d.-363.2 ng/g, n.d.-121.5 ng/g and n.d.-116.6 ng/g, respectively. Likewise, PAEs (∑ 6 PAEs), steranes and diasteranes concentrations from Mandovi estuary ranged from 60.1 to 271.9 ng/g, 2.33-40.1 ng/g and 2.28-23.0 ng/g, respectively. The PAEs comprising di-isobutyl phthalate (DIBP), dibutyl phthalate (DBP), an isomer peak for DBP, di(2-ethylhexyl) phthalate (DEHP), di-isononyl phthalate were dominant in Ashtamudi estuary sediments, while PAEs including diethyl phthalate, DIBP, DBP and its isomer, DEHP, di(2-ethylhexyl) terephthalate were detected in the Mandovi sediment samples. The results of this study show an insignificant correlation of TOC with PAEs, and indicates that the varying spatial distributions of the PAEs in both the estuaries can be the result of discharge sources. The higher concentration of PAE congeners was noticed in Ashtamudi, a Ramsar wetland site, that can be attributed to land-based plastic waste. The petroleum biomarkers were abundantly present in Mandovi estuary due to anthropogenic activities such as boating and spillage from oil tankers. The findings of the present study will serve as a reference point for future investigation of organic contaminants in Indian estuaries, and calls for attention towards implementing effective measures in controlling the pervasion of the PAEs and petroleum biomarkers., (Copyright © 2022 Elsevier Inc. All rights reserved.)

The sources and state of sedimentary organic matter (SOM) in fresh water aquatic systems are important to understand the carbon cycling in terrestrial environments. The composition of organic matter in the lake sediments demonstrates the physical and chemical condition of the lake ecosystems. However, the systematic and structured investigations focussed on to understand the source and fate of organic matters within eutrophic lakes is still far from clear. The present study is focusing on the implications of amino acids (AA), aliphatic hydrocarbons and bulk geochemical (C/N, δ 15 N) proxies to understand the distribution, sources and state of sedimentary organic matter in Ahansar Lake from Kashmir valley, India. The relatively low C/N ratios along with high AA contents indicate enhanced aquatic productivity in the lake system. Likewise, the dominance of the mid-chain monomethyl alkanes (MMAs), highly branched isoprenoids (HBIs), botryococcenes, steroids and triterpenoids suggest OM sourced from periphyton remains. Furthermore, the presence of C 27 , C 28 and C 29 diagenetically altered steroids also reflects a major algal contribution. The spatial variability of P aq demonstrates their applicability as a proxy for the contribution of aquatic vegetation. The ratio of individual amino acids (oxic/anoxic ratio) and low Pr/Ph (pristane/phytane) values indicate anoxic nature of the current depositional environment. This also leads to significant organic matter preservation as revealed by amino acid indices (e.g., degradation index - DI and reactivity index - RI). These data collectively demonstrate the systematic investigation and comprehensive understanding of source of sedimentary organic matters and respective depositional condition via multiple indicators. Overall, understanding the OM molecular composition and its spatial heterogeneity in a lake system is important to better constrain the fate of organic carbon, and assess the pollution risks as well as adopt relevant management strategies., (Copyright © 2021 Elsevier Inc. All rights reserved.)

The occurrence, distribution, characterization and quantification of microplastics (MPs) and phthalic acid esters (PAEs) from the freshwater aquatic environment are not thoroughly explored in the Indian Himalayas despite concern over their adverse effects on human health and ecosystem. In this study, we have investigated the presence of MPs and PAEs in an aquatic system from Indian subcontinent. The MPs were detected in all water and sediment samples with abundances ranging from 02-64 particles/L and 15-632 particles/kg dw, respectively. The abundance of MPs, dominated by polyethylene and polystyrene, with the majority being fibres and fragments indicated that they were derived from plastic paints, boats or synthetic products. The concentrations of PAEs in the surface sediment samples varied from 06-357 ng/g dw. The most abundant PAEs in the sediments were dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP), since they were present in all the samples collected from the lake basin. The relatively higher abundances of MPs and higher concentrations of PAEs were generally found in the vicinity of areas impacted by anthropogenic activities. A clear correlation between the abundance of microplastics and PAEs concentration was observed suggesting that they are closely attributed to a single source. This study also provides an alternative approach to utilize the chemical additives in plastics as markers to trace the presence and distribution of MPs in the aquatic environment., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Herein, we report a combination of pyrenedione ( PD ) and KO t Bu to achieve facile alcohol dehydrogenation under visible-light excitation, where aerobic oxygen is utilized as the terminal oxidant. The resulting carbonyl compound can be easily converted to vinyl nitriles in a single-pot reaction, at 60 °C in 6-8 h. This environmentally benign, organocatalytic approach has distinct advantages over transition-metal-catalyzed α-olefination of nitriles, which often operate at a significantly higher temperature for an extended reaction time.

A redox-active iminoquinone motif connected with π-delocalized pyrene core has been reported that can perform efficient two-electron oxidation of a class of substrates. The design of the molecule was inspired by the organic redox cofactor topaquinone (TPQ), which executes amine oxidation in the enzyme, copper amine oxidase. Easy oxidation of both primary and secondary alcohols happened in the presence of catalytic KOtBu, which could reduce the ligand backbone to its iminosemiquinonate form under photoinduced conditions. Moreover, this easy oxidation of alcohols under aerobic condition could be elegantly extended to multi-component, one-pot coupling for the synthesis of quinoline and pyrimidine. This organocatalytic approach is very mild (70 °C, 8 h) compared to a multitude of transition-metal catalysts that have been used to prepare these heterocycles. A detailed mechanistic study proves the intermediacy of the iminosemiquinonate-type radical and a critical hydrogen atom transfer step to be involved in the dehydrogenation reaction., (© 2020 Wiley-VCH GmbH.)