1. Performance of the pediatric logistic organ dysfunction-2 score in critically ill children requiring plasma transfusions
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Alvin Yiu, Suzan Cochius-den Otter, David Inwald, Rica Morzov, Stephen McKeever, Laura Campbell, Marie E. Steiner, Tracey Bushell, Aurélie Portefaix, Manuel Nieto Faza, Dan Nerheim, Marisa Tucci, Simon Erickson, Maria Teresa Alonso, Melissa Thomas, Amanda Johnson, Marc Andre Dugas, Miriam Rea, Petr Jirasek, David McKinley, Melania M. Bembea, Jennifer Sankey, Isobel MacLeod, Pierre Louis Leger, Elizabeth Scarlett, Marisa Vieira, Joan Balcells, Anna Deho, Erin Felkel, Amina Abdulla, Shancy Rooze, Maria José Solana, Davinia E. Withington, Scot T. Bateman, Arash Afshari, Olivier Brissaud, Peter Davis, Etienne Javouhey, Marcy Singleton, Pierre Tissieres, Stéphan Clénent de Cléty, Barry P. Markovitz, Lee Ann M. Christie, Carmel Delzoppo, Kelly Michelson, Lois Sanders, Anne Mette Baek Jensen, Tavey Dorofaeff, Nicola Kelly, Fleur Cour-Andlauer, John Beca, Maria Pisarcikova, Matthieu Maria, Miriam Santschi, Claire Sherring, Pierre Demaret, Simon J. Stanworth, Lasse Hoegh Andersen, Michael C. McCrory, Antonio Morales Martinez, Ariane Willems, Debbie Spear, Debbie Long, Douglas F. Willson, Sophie Raghunanan, Marc Trippaerts, Marianne E. Nellis, Caroline P. Ozment, Bettina Von Dessauer, Jennifer A. Muszynski, Nicolas Roullet-Renoleau, Saleh Alshehri, Bob Taylor, Annick De Jaeger, Sheila J. Hanson, Julie Guichoux, Nathan Smalley, Jesús López-Herce, Aimée Dorkenoo, Barney Scholefield, Sholeen Nett, Gavin Morrison, Marie-Hélène Perez, Christopher Babbitt, Dean Jarvis, Alice Bordessoule, Gunnar Bentsen, Kevin O’Brien, Katherine Woods, Marta Vazquez Moyano, Carsten Doell, Jens Christian Nilsson, Santiago Campos Mino, Vivianne Amiet, Samuel J. Ajizian, Karen Choong, Audrey Breining, Oliver Karam, Anna Camporesi, Kym Bain, Guillaume Mortamet, Richard Levin, Antonio Perez-Ferrer, Alain Duhamel, Janice Tijssen, Caroline Berghe, Marie Horan, Kathy Murkowski, Margaret M. Parker, Michelle Hoot, Tatsuya Kawasaki, Liz Rourke, Hannah Sparkes, Gordon Krahn, Lisa Steele, Andrew Michael, David Triscari, Jay Rilinger, David Wensley, Iolanda Jordan, Minal Parikh, Stéphane Leteurtre, Manal Alasnag, Jozef De Dooy, Alison Shefler, Nadia Ordenes, Nicolas Joram, Katie McCall, Daniel Martin, Jill M. Cholette, Renee A. Higgerson, Shira Gertz, Asumthia Jeyapalan, Marta Moniz, S. Faustino, Jose Carlos Flores González, Machelle Zink, Valerie Payen, Satnam Virdee, Edward J. Truemper, Julia Hickey, Elaine Gilfoyle, Federica Mario, Mariana Dumitrascu, Vanessa Rea, Joe Brierley, Gabriela Pereira, Lynette Wohlgemuth, Victoria Brown, Berber Kapitein, E. Vincent, Vicki L. Montgomery, Harry Steinherr, Kay C. Hawkins, Greg Wiseman, Mathias Johansen, Glenn Levine, Louise Gosselin, Warwick Butt, Jesús de Vicente Sánchez, Susan George, Amanda Galster, Alexandra Dinis, Filippia Nikolaou, Jeff Terry, Michelle Grunauer, Philip C. Spinella, Martin C. J. Kneyber, Shinya Miura, Mickael Afanetti, Andrea Kelleher, Neal J. Thomas, Kim Sykes, Anke Top, CHU Lille, Université de Lille, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, University of Oxford, University of Washington [Seattle], John Radcliffe Hospital [Oxford University Hospital], CHU Sainte Justine [Montréal], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University of Oxford [Oxford], PlasmaTV investigators, Butt, W., Delzoppo, C., Bain, K., Erickson, S., Smalley, N., Dorofaeff, T., Long, D., Wiseman, G., Clénent de Cléty, S., Berghe, C., de Jaeger, A., Demaret, P., Trippaerts, M., Willems, A., Rooze, S., De Dooy, J., Gilfoyle, E., Wohlgemuth, L., Tucci, M., Dumitrascu, M., Withington, D., Hickey, J., Choong, K., Sanders, L., Morrison, G., Tijssen, J., Wensley, D., Krahn, G., Dugas, M.A., Gosselin, L., Santschi, M., Von Dessauer, B., Ordenes, N., Afshari, A., Andersen, L.H., Nilsson, J.C., Johansen, M., Baek Jensen, A.M., Campos Mino, S., Grunauer, M., Joram, N., Roullet-Renoleau, N., Javouhey, E., Cour-Andlauer, F., Portefaix, A., Brissaud, O., Guichoux, J., Payen, V., Léger, P.L., Afanetti, M., Mortamet, G., Maria, M., Breining, A., Tissieres, P., Dorkenoo, A., Deho, A., Steinherr, H., Nikolaou, F., Camporesi, A., Mario, F., Kawasaki, T., Miura, S., Beca, J., Rea, M., Sherring, C., Bushell, T., Bentsen, G., Dinis, A., Pereira, G., Vieira, M., Moniz, M., Alshehri, S., Alasnag, M., Pisarcikova, M., Jordan, I., Balcells, J., Perez-Ferrer, A., de Vicente Sánchez, J., Vazquez Moyano, M., Morales Martinez, A., Lopez-Herce, J., Solana, M.J., Flores González, J.C., Alonso, M.T., Nieto Faza, M., Perez, M.H., Amiet, V., Doell, C., Bordessoule, A., Cochius-den Otter, S., Kapitein, B., Kneyber, M., Brierley, J., Rea, V., McKeever, S., Kelleher, A., Scholefield, B., Top, A., Kelly, N., Virdee, S., Davis, P., George, S., Hawkins, K.C., McCall, K., Brown, V., Sykes, K., Levin, R., MacLeod, I., Horan, M., Jirasek, P., Inwald, D., Abdulla, A., Raghunanan, S., Taylor, B., Shefler, A., Sparkes, H., Hanson, S., Woods, K., Triscari, D., Murkowski, K., Ozment, C., Steiner, M., Nerheim, D., Galster, A., Higgerson, R., Christie, L., Spinella, P.C., Martin, D., Rourke, L., Muszynski, J., Steele, L., Ajizian, S., McCrory, M.C., O'Brien, K., Babbitt, C., Felkel, E., Levine, G., Truemper, E.J., Zink, M., Nellis, M., Thomas, N.J., Spear, D., Markovitz, B., Terry, J., Morzov, R., Montgomery, V., Michael, A., Thomas, M., Singleton, M., Jarvis, D., Nett, S., Willson, D., Hoot, M., Bembea, M., Yiu, A., McKinley, D., Scarlett, E., Sankey, J., Parikh, M., Faustino, EVS, Michelson, K., Rilinger, J., Campbell, L., Gertz, S., Cholette, J.M., Jeyapalan, A., Parker, M., Bateman, S., Johnson, A., UCL - (SLuc) Service de soins intensifs, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
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medicine.medical_specialty ,Population ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology ,Organ Dysfunction Scores ,Internal medicine ,medicine ,030212 general & internal medicine ,10. No inequality ,Intensive care medicine ,education ,Children ,Outcome ,Pediatric intensive care unit ,education.field_of_study ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,ddc:618 ,business.industry ,Mortality rate ,Research ,Organ dysfunction ,Score ,Critical care ,Multiple organ failure ,Plasma transfusion ,030208 emergency & critical care medicine ,Clinical trial ,PlasmaTV investigators ,Observational study ,medicine.symptom ,business - Abstract
BACKGROUND: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions.METHODS: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer-Lemeshow test).RESULTS: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71-0.81) and the Hosmer-Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1.CONCLUSIONS: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
- Published
- 2016