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Abstract Brown tumors or osteitis fibrosa cystica are a rare bone metabolism disorder that may mimic cancer metastasis. It represents a late manifestation of prolonged and mostly unrecognized hyperparathyroidism. In this case report we present a 44-year-old female patient with multiple lesions detected on bone scintigraphy and 18F- FDG-PET/CT, initially interpreted as a bone metastatic disease, rather than multiple gigantocellular bone tumors. Additionally, the presented case emphasizes the importance of a multidisciplinary approach in diagnosing brown tumors as part of hyperparathyroidism, and the treatment decision.

Cigarette butts (CBs) are emerging soil contaminants, releasing chemicals upon contact with moisture. This study examined heavy metal concentrations leached from smoked and unsmoked CBs (Pall Mall, Philip Morris, and Marlboro) into OECD artificial soil and Vertisol soil and their accumulation in white mustard (Sinapis alba L.). Key physiological parameters, including germination rate, plant height, fresh weight, and dry weight, were analyzed, along with the uptake of heavy metals (Al, Fe, Mn, Zn, Ba, Ti, and Cu) and essential elements (Ca, Mg, Na, and K). Results showed that Mn had the highest bioaccumulation index (BAI = 1.10) in OECD soil, while Zn uptake was consistently high across soil types. Soil type significantly influenced plant height (χ2 = 41.269, p < 0.01) and elemental composition, with Vertisol soil facilitating greater overall growth and heavy metal uptake than OECD soil. MANOVA revealed no three-way interaction among soil type, CB use, and CB brand on elemental uptake. However, two-way interactions, particularly between soil type and CB use (F (4, 39) = 40.233, p < 0.001, Wilk’Λ = 0.195), showed significant effects on heavy metal uptake. These findings highlight the complex interactions influencing plant contamination, underlining the ecological risks of CB pollution in soils.

Wastewater from the textile industry is a complex mixture of many environmentally harmful substances such as unbound dyes and auxiliaries, pesticides, heavy metals and large quantities of salts associated with the dyes or the dyeing process. To reduce the wastewater load, action can be taken in two directions - firstly, by changing the charge of the cotton fibers to remove salts from the bath and increase the dye yield, and secondly, by producing filters for wastewater treatment. In the interest of sustainability, this article collects the possibilities of using cationized cotton during the mercerization process for this purpose. The results of zeta potential and coloristic parameters confirmed that the cationizated bleached and recycled cotton waste during the mercerization can be used in dyeing and printing without electrolyte, as well as filter for first step in water treatment.

Background: Flecainide is an anti-arrhythmic medication with a narrow therapeutic index and a high mortality rate, when overdosed. Few cases of flecainide toxicity in neonates and children due to medication error have been reported in the literature. A case of an accidental flecainide overdose in a neonate in Oman was presented. Case Presentation: A 19-day-old newborn girl developed persistent supra ventricular tachycardia (SVT) after receiving nebulized albuterol for acute bronchitis. After unsuccessful treatment with adenosine, she was given flecainide 5.6 mg orally every 24 hours for resolution of the SVT. On day four of admission, the child inadvertently received 100 mg of flecainide orally due to a dose calculation error. The child developed wide complex tachyarrhythmia followed by pulseless ventricular tachycardia (VT) requiring cardiopulmonary resuscitation. Sodium bicarbonate IV bolus followed by an infusion was administered. The patient developed two additional episodes of pulseless VT that coincided temporally with two interruptions of the sodium bicarbonate infusion, and required high dose of inotropic support. The patient developed convulsions but her brain ultrasound was normal. Her condition stabilized on day three after the toxicity occurred. Repeated echo showed a normal EF. The patient was discharged on propranolol and levetiracetam and was doing well on outpatient follow up. Conclusion: Flecainide is a potentially lethal medication in overdose due to its sodium channel blocking properties. Sodium bicarbonate remains an essential component of treatment. [SJEMed 2024; 5(1.000): 049-054]

Abstract Amongst fishes, zebrafish (Danio rerio) has gained popularity as a model system over most other species and while their value as a model is well documented, their usefulness is limited in certain fields of research such as behavior. By embracing other, less conventional experimental organisms, opportunities arise to gain broader insights into evolution and development, as well as studying behavioral aspects not available in current popular model systems. The anabantoid paradise fish (Macropodus opercularis), an “air-breather” species has a highly complex behavioral repertoire and has been the subject of many ethological investigations but lacks genomic resources. Here we report the reference genome assembly of M. opercularis using long-read sequences at 150-fold coverage. The final assembly consisted of 483,077,705 base pairs (~483 Mb) on 152 contigs. Within the assembled genome we identified and annotated 20,157 protein coding genes and assigned ~90% of them to orthogroups.

Recently, TechCrunch, a digital economy news site, noted that "Uber, the world's largest taxi company, owns no vehicles. Facebook, the world's most popular media owner, creates no content. Alibaba, the most valuable retailer, has no inventory. And Airbnb, the world's largest accommodation provider, owns no real estate, something interesting is happening." All these companies are involved in e-commerce business, namely the process of buying and selling products by electronic means, such as mobile applications and the Internet. In light of this, this study aimed to examine the relationship between e-commerce and digital economy, with a particular focus on the mediating role of customers' attitudes. To achieve this objective, the study employed a mixed research approach and adopted an explanatory research design. The target population consisted of all customers who are potential e-commerce users. Convenience sampling techniques were employed to collect data from respondents. The findings of the study revealed a positive and significant relationship between e-commerce and the digital economy, both in terms of direct and indirect effects. Additionally, the study identified the partial mediating role of customer attitudes in this relationship. Based on these findings, the study recommends that e-commerce companies should explore the potential of social networking media platforms such as Facebook and Instagram to further enhance overall e-commerce usage among customers. This strategic approach can complement their existing platforms and contribute to their growth and success in the digital economy.

Phenylketonuria (PKU) is an autosomal recessive inborn error of phenylalanine (Phe) metabolism, resulting from the deficient activity of phenylalanine hydroxylase that converts Phe to tyrosine in the liver, leading to elevated levels of Phe. Pegvaliase is an innovative and effective enzyme replacement therapy for reducing Phe concentration, but it has been associated with severe drug-induced hypersensitivity adverse events (HAEs). Limited data is available on the management of these HAEs, thus, we aimed to present a case report of a successful management strategy.The patient was a 28-year-old Caucasian male with classical PKU, who was otherwise healthy. Due to poor metabolic control, the pegvaliase treatment was initiated. The titration phase was uneventful, with transient and mild side effects, localized to the injection site. After the patient was on a maintenance dose of pegvaliase and had no reactions to the drug, we discontinued the H1-antihistamine. In the following days, within minutes after receiving the pegvaliase injection, an acute hypersensitivity reaction occurred that required emergency treatment. H1-antihistamine treatment was reintroduced. Four days after the incident he received pegvaliase under medical supervision and did not experience any symptoms.In conclusion, cautious reintroduction of pegvaliase in a hospital setting can be safely performed after HAE due to the discontinuation of H1-antihistamines. HAEs could be successfully mitigated by scheduling daily antihistamines administration closer to the pegvaliase injection. This approach can enable PKU patients to maintain their access to an effective and quality-of-life-improving therapy.

Despite many revolutionary asset pricing models developed over the past decades, traditional finance does not explain investor behavior very well. The purpose of this study is to examine the influence of behavioral biases on the investment decisions of investors of Pakistan Stock Exchange. In addition, the moderating influence of investment experience investigated in this study. The findings were reported using a sample of 230 individual investors, who make their own investments, typically through a mutual fund, bank, or internet broker. They make investments to achieve their unique investment objectives, such as saving for retirement, a child’s education, or increasing their overall wealth. The influence of behavioral biases on investment decisions was calculated using regression analysis. Regression results show that beta and t-values are significant and have a significant impact on investment decisions. Regression findings show that Confirmation Bias, Gamblers Fallacy Bias, Negativity Bias, Bandwagon Effect Bias, Loss Aversion Bias, and Overconfidence Bias all have a substantial impact on Investment Decisions. Status quo prejudice and endowment bias have a favorable but minor influence on Investment Decisions. Investment Experience is regarded as an essential component that contributes to successful decision making under risk and uncertainty, however the results of this study show that moderating variables have a minor influence. According to the findings, the moderating variable had no effect on the connection between behavioral biases and investment decisions. And the reason for this is that behavioral biases persist regardless of investing experience.

Abstract The research examined the ability of each treatment to recover a known quantity of particles and the impact on identifying polymer type using a microscope. By conducting extensive research on the changes induced in the chemical structures and morphologies of microplastics (MPs) there is potential for enhancing the detection and analysis of MPs by incorporating pre-treatment methods in the future. When treating environmental matrices with high organic content, chemical digestion treatment is required to get rid of microplastics and release particles. This type of treatment involves using a range of chemical agents, including acids, bases, and oxidizing agents. Unfortunately, there has been limited research into the chemical resistance of various types of microplastics to these substances. To address this issue, a study was conducted to examine the chemical resistance of four species of microplastics high-density polyethylene (HD-PE), low-density polyethylene (LD-PE), polypropylene (PP) and polyethylene terephthalate (PET) to hydrogen peroxide (H2O2), potassium hydroxide (KOH), nitric acid (HNO3) and acetic acid (CH3COOH). The results showed that acidic and alkaline substances were the most destructive to microplastics, while oxidative reagents resulted in fewer changes to plastic properties. These findings provide valuable insights into the properties of MPs and their response to strong acids, bases and oxidizing agents, which can serve as a reference for future studies on MP pre-treatment. In addition, used as a guideline to update current protocols and ensure that microplastics can be treated without causing damage.

Urban agriculture is closely tied to several of the Sustainable Development Goals. It can play a critical role in helping to achieve these goals by promoting sustainable food production and consumption, reducing greenhouse gas emissions, and creating more sustainable cities. It is also considered a pathway for overcoming food security in urban areas. However, this needs to be integrated with policies and regulations supported by sustainable finance. Due to COVID-19, conflict, and lack of infrastructure in Ethiopia, several challenges must be addressed to promote urban agriculture to aid food security. Hence, this study is conducted to examine how government policies and regulations promote urban agriculture through sustainable finance in Ethiopia. The study employed both an explanatory research design and a mixed research approach. Multi-stage sampling techniques that include (Simple random sampling techniques and judgmental sampling were used. The data was collected from selected micro and small enterprises engaged in urban agriculture. The structural and measurement model is estimated with the help of smart-pls software version 4. The study's finding implies that government policies and regulations have an insignificant effect on urban agriculture. At the same time, the study finding implies that sustainable finance has an important mediating role between urban agriculture and government policies. Hence, the impact of government policies and regulations on urban agriculture is found to have an indirect effect. Based on the study's findings, the study recommends that all stakeholders promote innovation and entrepreneurship that promote urban agriculture through sustainable finance.

Introduction The estimated prevalence of postpartum depression (PPD) worldwide, in China, and Shanghai is 17.2%, 18.0% and 23.2%, respectively. In 2021, Shanghai housed a population of 3.2 million childbearing-age migrant women, most of whom migrated to the city with their husbands for economic reasons. There is a general lack of help-seeking behaviour for mental disorders in China due to the perceived risk of social stigmatisation. In Shanghai, 70% of women did not seek professional help for perinatal mental health problems. We aim to gather information from multiple perspectives, such as the migrant women with PPD and perinatal depression (PND), their caregivers, health service providers and communities, to understand the help-seeking behaviour of postpartum migrant women with PPD or PND in China.Methods and analysis The Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework for Scoping Reviews will guide this review. A bilingual research librarian developed a comprehensive search strategy to retrieve published and unpublished English and Chinese studies involving factors influencing women’s PPD or PND help-seeking behaviour in China. This literature includes perceptions, views, patterns, acceptance and refusal, tendencies, probability, service accessibility and utilisation, and facts. We will search PubMed, Embase, Web of Science and CINAHL for English literature and CINKI for Chinese literature. Backward and forward snowball approaches will be used to identify additional relevant papers from the reference lists of selected papers. Two independent reviewers will screen the title and abstract and review the full text of selected papers to identify eligible articles for data extraction. We will build a Microsoft Access database to record the extracted data. The results will be presented in tables and a causal map to demonstrate the relationships between extracted variables and help-seeking behaviours for PPD and PND. A conceptual simulation model will be formulated based on the information from the literature to validate the logic of the relationships between variables, identify knowledge gaps and gain insights into potential intervention approaches. Experts and stakeholders will be invited to critique and comment on the results during group model building (GMB) workshops in Shanghai. These comments will be essential to validate the findings, receive feedback and obtain additional insights.Ethics and dissemination The literature review component of our study does not require ethical approval because the information and data collected will be obtained from publicly available sources and will not involve human subjects. Our collaborating research partner, International Peach Maternal Child Hospital, obtained the IRB approval (GKLW-A-2023-020-01) for screening and enrolling participants in GMB workshops. Stanford University received IRB approval under protocol number 67 419. The full review will be presented at a relevant conference and submitted to a peer-reviewed scientific journal for publication to report findings.

This thesis aims to determine the impact of applying the type of STAD assisted through leaflet media on the sophistication of the latest knowledge on the impact of class XI IPA 2 students at SMA Negeri 3 Waingapu. This type of research is an examination with a quantitative strategy, sampling using purposive sampling. The population of this study is all students of class XI IPA SMA Negeri 3 Waingapu even semester 2022/2023. This data pattern is that 36 students of XI IPA 1 experienced improvements due to increased elegance and 36 students of XI Science 2 due to experiments. The consequence of the descriptive assessment obtained stated that the pretest and posttest values for the experimental luxury were 53.52 < 84.58 at the same time as the pretest and posttest scores for the control were 52.69 < 75.83. Then the arrests were examined using paired t samples. the test produces an Asymp sig (2-tailed) of 0.000 which means

This study explores the impact of sodium periodate oxidation time (30 min, 60 min, or 120 min) and alginate coating on the capillarity of jute fabrics. Raw jute fabric exhibits a rapid increase in capillary rise height ( h ) over time, reaching 72 mm at 1200 s. Fabrics oxidized for 30, 60, and 120 min show significantly lower h values of 19, 18, and 28 mm at 1200 s, respectively, which can be ascribed to the oxidation process itself. Precisely, oxidation-induced conversion of hydroxyl groups of cellulose (the main constituent of jute fiber) to aldehyde groups contributed to the fabric reduced affinity for water, hence negatively affecting its capillarity. Approximately 47% and 55% lower h values of fabrics oxidized for 30 and 60 min compared to that oxidized for 120 min can be explained by their lower weight loss after oxidation as well as less pronounced liberation of elementary fibers. Oxidized fabrics characterized by low capillarity can be used for the manufacturing of packaging materials, outdoor gear, and protective covers for crops. To expand jute fabric applications in biocarpet engineering, that is, to obtain polysaccharide-based supports, raw and oxidized jute fabrics were treated with a 1% sodium alginate solution. At 1200 s, oxidized fabrics coated with alginate exhibited 4.3–5.8 times higher h values compared to solely oxidized counterparts. The diffusion coefficients of oxidized fabrics coated with alginate increase up to 35% with prolonged oxidation, emphasizing the oxidation impact on alginate binding.

Introduction In 2018, the American College of Obstetricians and Gynecologists recommended low-dose aspirin to prevent the onset of pre-eclampsia among women who were at high risk. Factors influencing women’s acceptance of this recommendation span multiple sectors and levels. Understanding how these factors interact will help stakeholders design effective population-level intervention strategies. Our study aims to identify and map relationships among factors influencing the medication decisions of pregnant women at risk of hypertensive disorders.Methods and analysis Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) guidelines will be followed for this review. A research librarian developed a comprehensive search strategy to retrieve published and unpublished English studies after 1 January 1980, involving factors that influence pregnant women’s uptake and adherence to medication for gestational hypertensive disorders. This literature includes perceptions, patterns, acceptance, refusal, tendencies, probability and service utilisation. We will search PubMed, Embase, Web of Science and CINAHL. Reference lists of the selected papers will be searched manually to identify more relevant studies. A two-stage independent screening, consisting of title and abstract screening, followed by full-text screening, will be conducted by two independent reviewers to identify eligible articles. Extracted data will be recorded in a customised variable extraction form and input into a Microsoft Access database. The PRISMA-ScR will be used to guide the presentation of the results, which will be presented in a table and causal map to demonstrate the relationships between extracted variables and medication uptake and adherence. A conceptual simulation model will be formulated to validate the logic of the relationships between variables and identify knowledge gaps. Lastly, experts and stakeholders will be invited to critique and comment on the results.Ethics and dissemination This study does not require ethical approval. The full review results will be presented at a relevant conference and submitted to a peer-reviewed scientific journal for publication.

Background Angiogenesis plays a key role in the development, maintenance, and progression of tumor. The incidence of non-Hodgkin's lymphoma (NHL) is increasing from the past three decades. Materials and Methods The aim of the study is to evaluate microvessel density (MVD) using CD34 monoclonal antibody and vascular endothelial growth factor (VEGF) using monoclonal antibody that were studied in pretreatment paraffin-embedded tissue samples of 60 cases. Results MVD was found to be increased in parallel with increasing grade of tumor. B-NHL had a mean MVD of 79.5 ± 8.8 (no./mm2), while T-NHL had a mean MVD of 183 ± 37.6 (no./mm2). VEGF expression was seen in 42 cases (70%), 20 cases (33.3%) showed strong VEGF expression, and the remainder showed either weak (36.6%) or no (30%) staining. Strong VEGF expression is seen in 100% cases of T-NHL and 77.7% cases of B-NHL. Mean MVD and VEGF expression was found to be correlated significantly with the histological grade of NHL (p = 0.001 and p = 0.000, respectively). Average microvessel counts were 53, 82.9, and 130.8 vessels (no./mm2) for negative, weak, and strong VEGF staining, respectively. These differences were statistically significant (p = 0.005 for strong vs. negative and p = 0.091 for strong vs. weak VEGF staining individually). Conclusion As the grade of tumor progresses, the angiogenic potential also advances which seems to depend on VEGF. The presence of higher MVD in high-grade lymphomas can be utilized for antiangiogenic drugs.

Abstract Background Several osteotomies are required for orthognathic surgery to reposition the jaws correctly. This study aimed to evaluate whether Kinesiotaping can reduce swelling, pain, and trismus following orthognathic surgery of the facial skull. Materials and methods The present study consists of two phases. In the split-mouth phase, 16 skeletal class III patients underwent Bimax Orthognathic surgery, and Kinesiological tape (KT) was applied on one half of the face. In the prospective case–control phase, 30 patients were divided into two groups. Kinesio tape was applied on both sides of the face of the Kinesio group, and pressure dressing and ice therapy were used for the second group. The tape was parallel to the lower border of the mandible along its entire length, tangent to the labial commissure area on the studied side. The tape was placed in place for 5 days. Edema was evaluated by measuring the distance from the menton to the lower edge of the tragus. The maximum mouth-opening trismus was evaluated, and the VAS index was used to evaluate pain. Results There was evidence of swelling reduction after KT; within the same study, differences between the left and right sides as well as for the same side were statistically significant (p

This study examines the effect of international financial flows, including investments and development assistance, on the expansion of renewable energy technologies. It also seeks to investigate the impact of the sectoral economy on the proportion of renewable energy consumption in Ethiopia. This study used an explanatory research design and a quantitative research approach. An autoregressive distributed lag model was applied to explore the long and short-term relationship among variables. A time series of data aggregated and disaggregated ranging from 2000 to 2022 was used. According to this study, sustainable finance programs are essential for advancing and aiding renewable energy projects in the long and short term. Ethiopia’s use of renewable energy will increase as sustainable finance rises. The main economic sectors determining Ethiopia’s consumption of renewable energy in the long and short term include the manufacturing, mining and service industries. This study’s findings imply that policies focusing on providing continuous financial support and fostering international cooperation to promote the development of the manufacturing sector are needed. This could include incentives for adopting renewable energy technologies and investing in renewable energy infrastructure. On the other hand, since the service and mining industries negatively impact renewable energy use, there is a need to diversify renewable energy sources beyond these sectors. This could involve promoting renewable energy projects in other sectors, such as manufacturing, agriculture, construction and trade. Based on the findings of this study, it is suggested that policymakers carefully consider the consequences within each economic sector when formulating decisions related to renewable energy. This study is novel in presenting empirical evidence linking renewable energy use to long- and short-term economic growth.

Dentigerous cyst is one of the most common odontogenic cysts of the jaw that slowly grows around an unerupted tooth crown. Nasopalatine duct cyst is a non-odontogenic common jaw cyst. Co-occurrence of nasopalatine duct cyst and dentigerous cyst in the same location of the same jaw is extremely rare. Odontogenic and non-odontogenic cysts occurring simultaneously in non-syndromic patients is rare. The lesions must be fully extracted by surgery. We report the treatment procedure of a patient suffering from this rare phenomenon. Keywords: Odontogenic cyst; Nonodontogenic cyst; Impacted tooth.

AbstractThis study aims to investigate whether organizational change capability (OCC) enables firms’ ambidexterity (explorative innovativeness and exploitative responsiveness) and results in above-average performance. Besides testing whether ambidexterity is possible, the study also investigates how it can be achieved by testing the role of mediators in the relationship between OCC and a firm’s performance. The study surveyed suppliers of a large Croatian firm from the construction industry. A total of 160 usable surveys were collected and data analysis was conducted using partial least squares structural equation modeling. Our study confirms the positive effect of OCC on a firm’s responsiveness and innovativeness, while also demonstrating that OCC has a positive impact on a firm’s performance. In addition, the results empirically show for the first time that OCC and innovativeness have a positive impact on a firm’s responsiveness. This study contributes to the understanding of the OCC construct by linking it to ambidexterity and investigating the role of mediators in the relationship between OCC and a firm’s performance.

This paper aims to explore the extent to which the pandemic has forced SMEs to accelerate their digital transformation efforts to remain competitive and adapt to the changing business landscape. The focus is set on three key research questions: (i) How did digitalization manifest itself in SMEs before the pandemic outbreak? (ii) how did SMEs’ digital transformation evolve during the pandemic? and (iii) what business challenges do SMEs face in the post-COVID period due to the acceleration of digital transformation? For the empirical investigation, qualitative research methods are used as in-depth interviews in 10 SMEs in Poland (six) and Croatia (4). The main results emphasize three main findings. First, even before the pandemic, SMEs recognized and used various digital transformation technologies to improve their business processes and performance. Second, the development of digitalization processes in the observed SMEs during the pandemic was mainly driven by the need for remote work, e-commerce, virtual events, and automation of business relationships among all stakeholders. Third, the post-pandemic world confirms the need for SMEs to invest in cybersecurity, talent acquisition, infrastructure, customer engagement, and data privacy to remain competitive in the digital economy.

This study aimed to find out how dicotyledonous medicinal plants were used in the Wailaboha Forest, Central Sumba Regency, and to use the research findings as a learning resource in the form of an encyclopedia. The descriptive quantitative technique was utilized. The subjects of this study were all dicotyledonous plants identified in the Hutan Wailaboha Kecamatan Umbu Ratu Nggay region. The samples in this study were dicotyledonous medicinal plants collected utilizing purposive sampling techniques at each research location. The double plot approach and observation plots were utilized to collect data in this investigation. This study's data analysis techniques were Relative Density, Relative Frequency, Significance Index, and Shannon-Wiener Diversity Index. At the same time, the validation team, including the head of MGMP and biology teachers in Central Sumba, assessed learning resources. The encyclopedia validation test yielded 98% for validator I, 89% for validator II, and 75% for validator III. This value suggests that the encyclopedia is usable and can help with learning. ABSTRAK:. Tujuan penelitian ini yaitu untuk mengetahui pemanfaatan tumbuhan obat dikotil di Hutan Wailaboha Kabupaten Sumba Tengah dan menjadikan hasil penelitian sebagai sumber belajar dalam bentuk Ensiklopedia. Metode yang digunakan adalah metode deskriptif kuantitatif. Subyek penelitian ini terdiri dari semua jenis tumbuhan dikotil yang terdapat dikawasan Hutan Wailaboha Kecamatan Umbu Ratu Nggay . Sampel dalam penelitian ini terdiri dari tumbuhan obat dikotil yang terdapat di setiap stasiun penelitian dengan menggunakan teknik purpose sampling. Teknik pengumpulan data dalam penelitian ini menggunakan metode petak ganda dan plot pengamatan. Teknik analisis data yang dilakukan dalam penelitian ini menggunakan Relative Density, Relative Frequency, Significance Index, dan Shannon-Wiener Diversity Index sedangkan penilaian sumber belajar dilakukan oleh tim validasi yaitu ketua MGMP dan guru-guru biologi di Sumba Tengah. Hasil uji validasi ensiklopedia oleh validator I yaitu 98%, validator II sebesar 89%, dan validator III sebesar 78,5%. Nilai tersebut menunjukkan bahwa ensiklopedia layak digunakan dan dapat menunjang proses pembelajaran.

ABSTRAK Pesatnya perkembangan teknologi informasi salah satunya dipengaruhi oleh perkembangan teknologi dan handphone yang semakin maju, sehingga dapat dikatakan perkembangan keduanya sangatlah erat dan berjalan beriringan. Multimedia merupakan gabungan beberapa komponen seperti teks, audio, video, animasi, dan gambar yang berguna untuk menunjang proses pembelajaran, karena visualisasi dalam bentuk animasi sangat diperlukan untuk materi yang disampaikan oleh guru. Tujuan dari penelitian ini adalah mengembangkan produk aplikasi android dan untuk mengetahui penilaian terhadap produk yang telah dihasilkan oleh peneliti dan peneliti dapat mengetahui respon produk kepada siswa. Hasil penilaian yang dilakukan responden terhadap produk yang dihasilkan peneliti adalah produk yang dihasilkan sangat baik, hal ini dibuktikan dengan total skor rata-rata sebesar 20 dengan keterangan produk yang dihasilkan sangat baik dimana produk tersebut dinilai dari beberapa aspek, termasuk kemudahan penggunaan, presentasi, keterbacaan dan peran multimedia. Kata kunci: Multimedia, Andromo, IPA ABSTRACT The rapid advancement of information technology, heavily influenced by the ever-advancing mobile phone technology, has led to a closely intertwined development of the two. Multimedia, comprising components such as text, audio, video, animation, and images, plays a vital role in supporting the learning process. This is especially important because visual aids, in the form of animations, are essential for conveying instructional material. The primary aim of this study is to evaluate the products created by the researchers. The significance of this research lies in enabling the researchers to identify areas for improvement in the multimedia products they have developed. The assessment conducted by respondents on the researcher-produced products yielded highly positive results, with an average score of 20. These results confirm the products' excellence, with evaluations encompassing factors like user-friendliness, presentation, readability, and the multimedia's overall contribution to the learning experience. keywords, Multimedia, Andromo, IPA

The purpose of this study is to investigate the potential opportunities and challenges of plastic products in Ethiopia. The study is qualitative in nature and a descriptive research design with the in-depth interview was used. The study employed both primary and secondary sources of data to investigate the study on hand. More specifically purposive sampling techniques were used to select the respondents for the interview. Discourse analysis was used in the study to recognize discursive interaction as a valuable tool for determining opinions, ideas, and facts about plastic products in Ethiopia. The study developed two different storylines regarding the opportunities and challenges of plastic products. As a result, the first storyline (S1) used taxing plastic products as an alternative strategy. The second storyline (S2) used banning plastic products as opoosing strategy. The study finding implies that having a tax on plastic products could provide more opportunities for the country than banning them. More specifically, taxing plastic products will be more appropriate for the generation of revenue, employment, industrial process, construction process, and recycling in Ethiopia. On the other hand, a lack of proper collection systems, separation of the source of disposal, a properly designed operating system, clear authorities and sanitation rules, organizational capacity, and unreliable collection services were found to existing challenges of plastic products. Governments and policymakers shall play a critical role in developing the necessary legislative framework to encourage mitigation actions that contribute to the reduction of plastic waste at the source, as well as encouraging the cleanup of plastic pollution on coastlines. Public discussion on alternative packaging than the one-time use of plastic products is also needed. Public awareness is required to change customer attitudes, and separation of organic and non-organic waste across the cities.

Green innovation is the creation of new and competitive products, services, processes, procedures and systems designed to use natural resources at a minimum level and to provide better quality of life on behalf of all that respects sustainability of the nature and of the future generations. The study objective was to examine the relationship between green innovation and financial performance. The study used an explanatory research design and a quantitative research approach to achieve the study's objective. Secondary time series data collected quarterly during the study period (2014–2020) was utilized to run the regression model. Autoregressive moving average (ARIMA) was used to forecast the growing level of green financial innovation transactions, and autoregressive distributed lag model (ARDL) was used to examine the effect of green financial innovation transactions on financial performance. According to forecasted results, on average green financial innovation transaction is expected to grow by 11 percent each quarter, and its impact on financial performance is found positive and significant in the short run. However, the long-run estimation of ARDL shows the positive and insignificant effect of green financial innovation on financial performance. Based on the study's findings, we recommend that the banking sector focuses on adopting green financial innovations to improve financial performance by taking into account both the short-run and long-run benefits of the products. At the same time, we suggest that the sector focus on those green financial innovations which have the lowest adoption and development costs compared to others since the long-run effect affects the overall financial performance of the sector. The main contribution of this study is to provide future indication on the relationship between the two variables in order to provide proper decision making in a bid to make green innovation investment.

Objectives Hypocellular bone marrow (BM) disorders comprise heterogeneous entities associated with peripheral cytopenias and decreased production of hematopoietic cells in BM. This study was undertaken to analyze immunohistochemical expression of CD34, CD117, and p53 in morphologically diagnosed patients of hypocellular BM (aplastic anemia [AA], hypocellular myelodysplastic syndrome [h-MDS], and hypocellular acute myeloid leukemia [h-AML]). Materials and Methods BM specimens were obtained from patients presenting with pancytopenia/bicytopenia. On 30 patients diagnosed as hypocellular BM, immunohistochemistry (IHC) for CD34, CD117, and p53 was performed. Results BM cellularity was

This investigation was performed to determine whether and how the implementation of open educational practices (OEP) is directly influenced by lecturers' backgrounds and preferences in terms of teaching modalities. In particular, we have analysed the use of OEPs from a social perspective to understand whether the habit to work in online and blended settings is connected to the use of open teaching approaches. Exploring this relationship has evidenced common patterns that suggest how lecturers can be further motivated to explore areas of openness where they are not advanced concerning classroom diversity and increase the social impact of their teaching. This research shows two main approaches to openness: one focused on open educational resources only and another one with a broader perspective that embraces other aspects of openness, such as access or practices. This work will help understand the relevance of contextual variables and further explore enablers for building open education capacity across universities.

Abstract Amoebic Gill Disease (AGD), caused by the protozoan extracellular parasite Paramoeba perurans (P. perurans) is a disease affecting Atlantic salmon (Salmo salar). This study investigated the gill transcriptomic profile of pre-clinical AGD using RNA-sequencing (RNA-seq) technology. RNA-seq libraries generated at 0, 4, 7, 14 and 16 days post infection (dpi) identified 19,251 differentially expressed genes (DEGs) of which 56.2% were up-regulated. DEGs mapped to 224 Gene Ontology (GO) terms including 140 biological processes (BP), 45 cellular components (CC), and 39 molecular functions (MF). A total of 27 reference pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) and 15 Reactome gene sets were identified. The RNA-seq data was validated using real-time, quantitative PCR (qPCR). A host immune response though the activation of complement and the acute phase genes was evident at 7 dpi, with a concurrent immune suppression involving cytokine signalling, notably in interleukins, interferon regulatory factors and tumour necrosis factor-alpha (tnf-α) genes. Down-regulated gene expression with involvement in receptor signalling pathways (NOD-like, Toll-like and RIG-1) were also identified. The results of this study support the theory that P. perurans can evade immune surveillance during the initial stages of gill colonisation through interference of signal transduction pathways.

Abstract Background As hospitals have grown more complex, the ethical concerns they confront have grown correspondingly complicated. Many hospitals have consequently developed health care ethics programs (HCEPs) that include far more than ethics consultation services alone. Yet systematic research on these programs is lacking. Methods Based on a national, cross-sectional survey of a stratified sample of 600 US hospitals, we report on the prevalence, scope, activities, staffing, workload, financial compensation, and greatest challenges facing HCEPs. Results Among 372 hospitals whose informants responded to an online survey, 97% of hospitals have HCEPs. Their scope includes clinical ethics functions in virtually all hospitals, but includes other functions in far fewer hospitals: ethical leadership (35.7%), regulatory compliance (29.0%), business ethics (26.2%), and research ethics (12.6%). HCEPs are responsible for providing ongoing ethics education to various target audiences including all staff (77.0%), nurses (59.9%), staff physicians (49.0%), hospital leadership (44.2%), medical residents (20.3%) and the community/general public (18.4%). HCEPs staff are most commonly involved in policy work through review of existing policies but are less often involved in development of new policies. HCEPs have an ethics representative in executive leadership in 80.5% of hospitals, have representation on other hospital committees in 40.7%, are actively engaged in community outreach in 22.6%, and lead large-scale ethics quality improvement initiatives in 17.7%. In general, major teaching hospitals and urban hospitals have the most highly integrated ethics programs with the broadest scope and greatest number of activities. Larger hospitals, academically affiliated hospitals, and urban hospitals have significantly more individuals performing HCEP work and significantly more individuals receiving financial compensation specifically for that work. Overall, the most common greatest challenge facing HCEPs is resource shortages, whereas underutilization is the most common greatest challenge for hospitals with fewer than 100 beds. Respondents’ strategies for managing challenges include staff training and additional funds. Conclusions While this study must be cautiously interpreted due to its limitations, the findings may be useful for understanding the characteristics of HCEPs in US hospitals and the factors associated with these characteristics. This information may contribute to exploring ways to strengthen HCEPs.

Abstract The causative agent of amoebic gill disease, Neoparamoeba perurans is reported to lose virulence during prolonged in vitro maintenance. In this study, the impact of prolonged culture on N. perurans virulence and its proteome was investigated. Two isolates, attenuated and virulent, had their virulence assessed in an experimental trial using Atlantic salmon smolts and their bacterial community composition was evaluated by 16S rRNA Illumina MiSeq sequencing. Soluble proteins were isolated from three isolates: a newly acquired, virulent and attenuated N. perurans culture. Proteins were analysed using two-dimensional electrophoresis coupled with liquid chromatography tandem mass spectrometry (LC–MS/MS). The challenge trial using naïve smolts confirmed a loss in virulence in the attenuated N. perurans culture. A greater diversity of bacterial communities was found in the microbiome of the virulent isolate in contrast to a reduction in microbial community richness in the attenuated microbiome. A collated proteome database of N. perurans, Amoebozoa and four bacterial genera resulted in 24 proteins differentially expressed between the three cultures. The present LC–MS/MS results indicate protein synthesis, oxidative stress and immunomodulation are upregulated in a newly acquired N. perurans culture and future studies may exploit these protein identifications for therapeutic purposes in infected farmed fish.

This work aims at summarizing the experience gained in the organization and delivery of a short-intensive and transdisciplinary teaching course offered inside the University College of Merit “Collegio Universitario Renato Einaudi” (Torino, Italy). Colleges of merit are shared residential facilities designed to accommodate talented students with high motivation and commitment, regularly enrolled in the different higher education levels ranging from bachelor to doctoral programs. Several services are also offered to support their personal and professional growth. This goal is usually achieved through both tutoring and complementary cultural activities. Collegio Einaudi is a private Foundation connected to the University of Turin and the Politecnico di Torino (PoliTo). It was founded in 1935 and hosts about 800 students who are asked to develop various transdisciplinary skills through internal courses defined once a year around a theme. The courses are jointly organized with lecturers and university research groups. In the academic year 2020/21, the chosen central theme is “resilience”. Within the booklet course proposals, structured as a ThinkLab, “We have an IDEA” - Instructional Design Elementary Application - aims to co-redesign the first-year engineering courses offered by PoliTo. PoliTo is an Italian public University offering both Engineering and Architectural tracks. Around 5000 freshmen are enrolled every year in the Engineering bachelor’s degree programs. During the first year, the students are divided into 20 parallel classes of about 250 each. The addressed topics provide a common background and include Chemistry, Computer Science, Mathematical Analysis I, Linear Algebra and Geometry and Physics I. The emphasis of this contribution is on the description of the “We have an IDEA” laboratory and on the evaluation of its impact on the University daily lives. In the following section, the theoretical framework is defined. The remaining part of the paper discusses the Laboratory’s design, the Results, and the Conclusions.

The bone health guidelines for breast cancer (BC) patients recommend bone mineral density (BMD) testing. Patients with low BMD and elevated serum calcium levels (SCLs) are further evaluated for primary hyperparathyroidism (PHPT). We aimed to determine the prevalence of PHPT in treated BC patients with low BMD and analyze the association of SCLs with histopathologic tumor features and cancer treatment. This retrospective study included postmenopausal BC patients examined at Osteoporosis Clinic between 2013 and 2020. Clinical and BMD data were collected from patient medical records. Patients with biochemical suspicion of PHPT underwent standard parathyroid imaging procedures. Nine out of 137 (6.6%) patients were diagnosed with PHPT; 8/9 patients underwent parathyroidectomy and one patient was advised to follow-up. Among the rest of 128 non-PHPT patients, higher SCLs showed a trend of positive association with higher tumor grade and axillary lymph node involvement, and received immunotherapy, although without statistical significance. We found a higher prevalence of PHPT in treated BC patients compared to the general population. Higher SCLs show a trend of positive correlation with some more aggressive histopathologic tumor features and with immunotherapy. The results of this study suggest that assessment of SCLs should be routinely performed to rule out PHPT in treated BC patients with low BMD.

The electronic cigarette (EC), was initially introduced as a safe alternative to conventional cigarette smoking While initially seemingly innocuous, over 2800 E-cigarette, or Vaping, product use-associated lung injury (EVALI) cases have been reported in the USA, with a spectrum of clinical severity ranging from mild dyspnea to overt respiratory failure In this report we highlight three EVALI cases whom presented with dyspnea and a variety of non-specific symptoms. Diagnostic imaging demonstrated bilateral reticular infiltrates and ground-glass opacities with lymphadenopathy. Clinically, patients failed to respond to empiric antibiotics but improved after initiating steroids. Consistent with prior case series, our patients reported exposure to EC liquids containing tetrahydrocannabinol (THC)/cannabidiols (CBD) additives, suggesting Vitamin E acetate as the potentially harmful constituent. In this case series and review, we not only summarize prior clinical studies that have evaluated the effects of vaping on cardiopulmonary function as well as case reports on EVALI, but also discuss the pathophysiology of vaping and EVALI. It remains unclear not only why some individuals develop EVALI, but why the clinical and pathological presentations vary. EVALI remains a significant public health concern and clinicians must maintain a high index of suspicion for this novel phenomenon.

Background: Due to the increase in gastrointestinal diseases, the use of low-potency herbal medicines for treatment has increased. The synergistic effect of Glycyrrhiza glabra and Astragalus gossypinus on the healing of gastric ulcers is the aim of this study Materials & Methods: The both plants were harvested and extracted. The most appropriate dose for the use of Glycyrrhiza glabra extract in experiments, 200 mg / kg / day, was determined by performing writing tests and carrageenan. Then, to create of gastric ulcer in rats, rats were gavaged for 3 days with a dose of 200 mg/kg/day of dissolved aspirin in 1% Carbocyte methylcellulose. The groups were treated with dose 200 mg / kg / day (Concentration of 0.363 mg / ml) of both extracts and distilled water for 14 days. Four gastric ulcer rat groups, respectively, received both extracts, Glycyrrhiza glabra extract, omeprazole and distilled water as a positive control group, and the fifth group or negative control group Without gastric ulcer received distilled water. After the treatment period, the rats were described and ulcers were examined under microscopic and pathological examination. Results: Both extracts together (200 mg/kg/day) reduced the wound coefficient significantly (P

Background Multiple myeloma (MM) is a plasma cell disorder characterized by monoclonal proliferation of plasma cells in bone marrow. Plasmablastic MM is a morphologic subset of MM, containing ≥2% plasmablasts of all plasma cells. Methods The study included 30 consecutively diagnosed patients of MM (6 plasmablastic, 24 nonplasmablastic) over a span of 2 years. Angiogenesis in MM was assessed by analysis of vascular endothelial growth factor (VEGF) immunoexpression by plasma cells and microvessel density (MVD) using anti-CD34 antibody. CD34 and VEGF immunohistochemical staining was performed in all the 30 cases. Angiogenesis was studied in relation to plasmablastic morphology and clinical profile to determine if any correlation exists between these. Results The mean VEGF expression of 80.83 ± 7.36 in plasmablastic myeloma cases was significantly higher compared with a mean VEGF of 53.54 ±17.09 in nonplasmablastic cases. Most of the cases (66.6%) of plasmablastic myeloma exhibited strong (3+) VEGF expression. The difference in mean VEGF expression between plasmablastic and nonplasmablastic cases was found to be statistically significant (p = 0.001). The mean MVD in plasmablastic cases was 44.8 ± 3.69, while in the nonplasmablastic category, the mean MVD was 23.7 ± 5.14, difference being statistically significant (p < 0.05). Also, a positive correlation was found between VEGF expression and MVD. Conclusion A moderate/strong VEGF intensity and higher MVD were found in cases of plasmablastic MM, suggesting that a more aggressive histological disease may be associated with increased production of VEGF. This finding might be helpful to identify a subset of patients with adverse prognosis and to provide antiangiogenic therapy to improve their survival. However, studies comprising larger number of patients are required to bring out a statistical significance to further substantiate these findings.

Acute kidney injury (AKI) is a common occurrence in the neonatal intensive care unit (NICU). In recent years, our knowledge of the incidence and impact of neonatal AKI on outcomes has expanded exponentially. Neonatal AKI has been shown to be associated with adverse outcomes including increased length of mechanical ventilation, prolonged length of stay, and rise in mortality. There has also been increasing work suggesting that neonates with AKI are at higher risk of chronic kidney disease (CKD). In the past, AKI had been defined multiple ways. The utilization of the neonatal modified Kidney Disease: Improving Global Outcomes (KDIGO) criteria as the standard definition for neonatal AKI in research and clinical care has driven the advances in our understanding of neonatal AKI over the last 10 years. This definition has allowed researchers and clinicians to better understand the incidence, risk factors, and outcomes associated with neonatal AKI across populations through a multitude of single-center studies and the seminal, multicenter Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) study. As the impacts of neonatal AKI have become clear, a shift in efforts toward identifying those at highest risk, protocolizing AKI surveillance, improving prevention and diagnosis, and expanding kidney support therapy (KST) for neonates has occurred. These efforts also include improving risk stratification (identifying high risk populations, including those with nephrotoxic medication exposure) and diagnostics (novel biomarkers and diagnostic tools). Recent work has also shown that the targeted use of methylxanthines may prevent AKI in a variety of high-risk populations. One of the most exciting developments in neonatal AKI is the advancement in technology to provide KST to neonates with severe AKI. In this comprehensive review we will provide an overview of recent work and advances in the field of neonatal AKI. This will include a detailed review of (1) the definition of neonatal AKI, (2) the epidemiology, risk factors, and outcomes associated with neonatal AKI, (3) improvements in risk stratification and diagnostics, (4) mitigation and treatment, (5) advancements in the provision of KST to neonates, and (6) the incidence and risk of subsequent CKD.

The stone crayfish, Austropotamobius torrentium, is a native European freshwater species sensitive to habitat alterations such as stream channelization and urban development, putting its populations at risk. This study aims to assess how habitat alteration and subsequent water quality changes affect the stone crayfish population in the Kustošak Stream (Croatia) through three selected sites under different levels of anthropogenic disturbance: (1) undisturbed; (2) recently modified, and (3) long-time modified sites. At each site, crayfish were captured, measured, and marked to estimate population size, structure, and crayfish condition. Additionally, we examined whether water quality (18 measured physicochemical parameters) affects relative crayfish abundance. We also used mitochondrial sequencing and microsatellite genotyping to assess species genetic diversity and population connectivity and to compare results among the sites. The results showed that habitat alteration caused an overall reduction in population abundance and changes in size structure; however, it had not yet resulted in detectable genetic differences. Partial least squares regression showed that crayfish abundance was affected by the physicochemical parameters of water, including, among others, oxygen, calcium ions, nitrates, pH, and water temperature. We discuss our findings in the context of the effects of anthropogenic disturbance on the viability and persistence of this EU priority species.