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1. Significant pain decrease in children with non-systemic Juvenile Idiopathic Arthritis treated to target: results over 24 months of follow up

Author

Spekking, Katinka, Anink, Janneke, de Boer, Piroska, Bergstra, Sytske Anne, van den Berg, J. Merlijn, Schonenberg-Meinema, Dieneke, van Suijlekom-Smit, Lisette W. A., van Rossum, Marion A. J., Koopman-Keemink, Yvonne, Cate, Rebecca ten, Allaart, Cornelia F., Brinkman, Daniëlle M. C., and Muller, Petra C. E. Hissink

Published
2023
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2. Long-term quality of life and functional outcome of patients with juvenile idiopathic arthritis in the biologic era: a longitudinal follow-up study in the Dutch Arthritis and Biologicals in Children Register

Author

Anink, Janneke, Prince, Femke H. M., Dijkstra, Maryanne, Otten, Marieke H., Twilt, Marinka, ten Cate, Rebecca, Gorter, Simone L., Koopman-Keemink, Yvonne, van Rossum, Marion A. J., Hoppenreijs, Esther P. A., and van Suijlekom-Smit, Lisette W. A.

Published
2015
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3. Trends in prescription of biological agents and outcomes of juvenile idiopathic arthritis: results of the Dutch national Arthritis and Biologics in Children Register

Author

Otten, Marieke H, Anink, Janneke, Prince, Femke H M, Twilt, Marinka, Vastert, S J, ten Cate, Rebecca, Hoppenreijs, Esther P A H, Armbrust, Wineke, Gorter, Simone L, van Pelt, Philomine A, Kamphuis, Sylvia S M, Dolman, Koert M, Swart, Joost F, van den Berg, J Merlijn, Koopman-Keemink, Yvonne, van Rossum, Marion A J, Wulffraat, Nico M, and van Suijlekom-Smit, Lisette W A

Published
2015
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5. Treatment choices of paediatric rheumatologists for juvenile idiopathic arthritis: etanercept or adalimumab?

Author

Anink, Janneke, Otten, Marieke H., Gorter, Simone L., Prince, Femke H. M., van Rossum, Marion A. J., van den Berg, J. Merlijn, van Pelt, Philomine A., Kamphuis, Sylvia, Brinkman, Danielle M. C., Swen, Wijnand A. A., Swart, Joost F., Wulffraat, Nico M., Dolman, Koert M., Koopman-Keemink, Yvonne, Hoppenreijs, Esther P. A. H., Armbrust, Wineke, ten Cate, Rebecca, and van Suijlekom-Smit, Lisette W. A.

Published
2013
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6. Effectiveness and safety of a second and third biological agent after failing etanercept in juvenile idiopathic arthritis: results from the Dutch National ABC Register

Author

Otten, Marieke H, Prince, Femke H M, Anink, Janneke, ten Cate, Rebecca, Hoppenreijs, Esther P A H, Armbrust, Wineke, Koopman-Keemink, Yvonne, van Pelt, Philomine A, Kamphuis, Sylvia, Gorter, Simone L, Dolman, Koert M, Swart, Joost F, van den Berg, J Merlijn, Wulffraat, Nico M, van Rossum, Marion A J, and van Suijlekom-Smit, Lisette W A

Published
2013
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7. Tumour necrosis factor-blocking agents in persistent oligoarticular juvenile idiopathic arthritis: results from the Dutch Arthritis and Biologicals in Children Register

Author

Anink, Janneke, Otten, Marieke H., Prince, Femke H. M., Hoppenreijs, Esther P. A. H., Wulffraat, Nico M., Swart, Joost F., ten Cate, Rebecca, van Rossum, Marion A. J., van den Berg, J. Merlijn, Dolman, Koert M., Koopman-Keemink, Yvonne, Armbrust, Wineke, Kamphuis, Sylvia, van Pelt, Philomine A., Gorter, Simone L., and van Suijlekom-Smit, Lisette W. A.

Published
2013
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8. A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis:challenges and opportunities

Author

Beukelman, Timothy, Anink, Janneke, Berntson, Lillemor, Duffy, Ciaran, Ellis, Justine A., Glerup, Mia, Guzman, Jaime, Horneff, Gerd, Kearsley-Fleet, Lianne, Klein, Ariane, Klotsche, Jens, Magnusson, Bo, Minden, Kirsten, Munro, Jane E., Niewerth, Martina, Nordal, Ellen Berit, Ruperto, Nicolino, Santos, Maria José, Schanberg, Laura E., Thomson, Wendy, Suijlekom-Smit, Lisette van, Wulffraat, Nico, Hyrich, Kimme, and Pediatrics

Subjects
Medicin och hälsovetenskap, Registry, lcsh:Diseases of the musculoskeletal system, Pharmacosurveillance, Adolescent, VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803, Medical and Health Sciences, Cohort Studies, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Pediatri: 760, Observational study, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Pediatrics: 760, Journal Article, Humans, Pediatric rheumatology, Registries, Child, lcsh:RJ1-570, Australia, lcsh:Pediatrics, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759, Juvenile idiopathic arthritis, Arthritis, Juvenile, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759, Europe, Observational Studies as Topic, VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803, Research Design, Antirheumatic Agents, North America, lcsh:RC925-935, Research Article
Abstract

BackgroundTo characterize the existing national and multinationalregistries and cohortstudies in juvenile idiopathic arthritis (JIA) and identify differences as well asareas of potential future collaboration.MethodsWe surveyed investigators from North America, Europe, and Australia aboutexisting JIA cohort studies and registries. We excluded crosssectionalstudies.We captured information about study design, duration, location, inclusioncriteria, data elements and collection methods.criteria, data elements and collection methods.ResultsWe received survey results from 18 studies, including 11 national and 7 multinationalstudies representing 37 countries in total. Study designs includedinception cohorts, prevalent disease cohorts, and new treatment cohorts (severalof which contribute to pharmacosurveillance activities). Despite numerousdifferences, the data elements collected across the studies was quite similar, withmost studies collecting at least 5 of the 6 American College of Rheumatologycore set variables and the data needed to calculate the 3variableclinical juvenile disease activity score. Most studies were collecting medication initiation anddiscontinuation dates and were attempting to capture serious adverse events.ConclusionThere is a widerange of large, ongoing JIA registries and cohort studies aroundthe world. Our survey results indicate significant potential for futurecollaborative work using data from different studies and both combined andcomparative analyses.

Published
2017
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9. S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis

Author

Gohar, Faekah, primary, Anink, Janneke, additional, Moncrieffe, Halima, additional, Van Suijlekom-Smit, Lisette W.A., additional, Prince, Femke H.M., additional, van Rossum, Marion A.J., additional, Dolman, Koert M., additional, Hoppenreijs, Esther P.A.H., additional, ten Cate, Rebecca, additional, Ursu, Simona, additional, Wedderburn, Lucy R., additional, Horneff, Gerd, additional, Frosch, Michael, additional, Foell, Dirk, additional, and Holzinger, Dirk, additional

Published
2018
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10. A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis : challenges and opportunities

Author

Beukelman, Timothy, Anink, Janneke, Berntson, Lillemor, Duffy, Ciaran, Ellis, Justine A., Glerup, Mia, Guzman, Jaime, Horneff, Gerd, Kearsley-Fleet, Lianne, Klein, Ariane, Klotsche, Jens, Magnusson, Bo, Minden, Kirsten, Munro, Jane E., Niewerth, Martina, Nordal, Ellen, Ruperto, Nicolino, Santos, Maria Jose, Schanberg, Laura E., Thomson, Wendy, van Suijlekom-Smit, Lisette, Wulffraat, Nico, Hyrich, Kimme, Beukelman, Timothy, Anink, Janneke, Berntson, Lillemor, Duffy, Ciaran, Ellis, Justine A., Glerup, Mia, Guzman, Jaime, Horneff, Gerd, Kearsley-Fleet, Lianne, Klein, Ariane, Klotsche, Jens, Magnusson, Bo, Minden, Kirsten, Munro, Jane E., Niewerth, Martina, Nordal, Ellen, Ruperto, Nicolino, Santos, Maria Jose, Schanberg, Laura E., Thomson, Wendy, van Suijlekom-Smit, Lisette, Wulffraat, Nico, and Hyrich, Kimme

Abstract

Background: To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration. Methods: We surveyed investigators from North America, Europe, and Australia about existing JIA cohort studies and registries. We excluded cross-sectional studies. We captured information about study design, duration, location, inclusion criteria, data elements and collection methods. Results: We received survey results from 18 studies, including 11 national and 7 multi-national studies representing 37 countries in total. Study designs included inception cohorts, prevalent disease cohorts, and new treatment cohorts (several of which contribute to pharmacosurveillance activities). Despite numerous differences, the data elements collected across the studies was quite similar, with most studies collecting at least 5 of the 6 American College of Rheumatology core set variables and the data needed to calculate the 3-variable clinical juvenile disease activity score. Most studies were collecting medication initiation and discontinuation dates and were attempting to capture serious adverse events. Conclusion: There is a wide-range of large, ongoing JIA registries and cohort studies around the world. Our survey results indicate significant potential for future collaborative work using data from different studies and both combined and comparative analyses.

Published
2017
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11. A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities

Author

Cluster B, Infection & Immunity, Regenerative Medicine and Stem Cells, Child Health, Divisieleiding O&O, BOO, Immunologie/Reumatologie, Infectiezieken, Beukelman, Timothy, Anink, Janneke, Berntson, Lillemor, Duffy, Ciaran, Ellis, Justine A, Glerup, Mia, Guzman, Jaime, Horneff, Gerd, Kearsley-Fleet, Lianne, Klein, Ariane, Klotsche, Jens, Magnusson, Bo, Minden, Kirsten, Munro, Jane E, Niewerth, Martina, Nordal, Ellen, Ruperto, Nicolino, Santos, Maria Jose, Schanberg, Laura E, Thomson, Wendy, van Suijlekom-Smit, Lisette, Wulffraat, Nico, Hyrich, Kimme, Cluster B, Infection & Immunity, Regenerative Medicine and Stem Cells, Child Health, Divisieleiding O&O, BOO, Immunologie/Reumatologie, Infectiezieken, Beukelman, Timothy, Anink, Janneke, Berntson, Lillemor, Duffy, Ciaran, Ellis, Justine A, Glerup, Mia, Guzman, Jaime, Horneff, Gerd, Kearsley-Fleet, Lianne, Klein, Ariane, Klotsche, Jens, Magnusson, Bo, Minden, Kirsten, Munro, Jane E, Niewerth, Martina, Nordal, Ellen, Ruperto, Nicolino, Santos, Maria Jose, Schanberg, Laura E, Thomson, Wendy, van Suijlekom-Smit, Lisette, Wulffraat, Nico, and Hyrich, Kimme

Published
2017

12. A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities

Author

Beukelman, T, Anink, Janneke, Berntson, L, Duffy, C, Ellis, JA, Glerup, M, Guzman, J, Horneff, G, Kearsley-Fleet, L, Klein, A, Klotsche, J, Magnusson, B, Minden, K, Munro, JE, Niewerth, M, Nordal, E, Ruperto, N, Santos, MJ, Schanberg, LE, Thomson, W, Smit, LWA, Wulffraat, N, Hyrich, K, Beukelman, T, Anink, Janneke, Berntson, L, Duffy, C, Ellis, JA, Glerup, M, Guzman, J, Horneff, G, Kearsley-Fleet, L, Klein, A, Klotsche, J, Magnusson, B, Minden, K, Munro, JE, Niewerth, M, Nordal, E, Ruperto, N, Santos, MJ, Schanberg, LE, Thomson, W, Smit, LWA, Wulffraat, N, and Hyrich, K

Published
2017

13. A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities

Author

Beukelman, Timothy, primary, Anink, Janneke, additional, Berntson, Lillemor, additional, Duffy, Ciaran, additional, Ellis, Justine A., additional, Glerup, Mia, additional, Guzman, Jaime, additional, Horneff, Gerd, additional, Kearsley-Fleet, Lianne, additional, Klein, Ariane, additional, Klotsche, Jens, additional, Magnusson, Bo, additional, Minden, Kirsten, additional, Munro, Jane E., additional, Niewerth, Martina, additional, Nordal, Ellen, additional, Ruperto, Nicolino, additional, Santos, Maria Jose, additional, Schanberg, Laura E., additional, Thomson, Wendy, additional, van Suijlekom-Smit, Lisette, additional, Wulffraat, Nico, additional, and Hyrich, Kimme, additional

Published
2017
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17. Trends in prescription of biological agents and outcomes of juvenile idiopathic arthritis : results of the Dutch national Arthritis and Biologics in Children Register

Author

Otten, Marieke H., Anink, Janneke, Prince, Femke H. M., Twilt, Marinka, Vastert, S. J., ten Cate, Rebecca, Hoppenreijs, Esther P. A. H., Armbrust, Wineke, Gorter, Simone L., van Pelt, Philomine A., Kamphuis, Sylvia S. M., Dolman, Koert M., Swart, Joost F., van den Berg, J. Merlijn, Koopman-Keemink, Yvonne, van Rossum, Marion A. J., Wulffraat, NM, van Suijlekom-Smit, Lisette W. A., Otten, Marieke H., Anink, Janneke, Prince, Femke H. M., Twilt, Marinka, Vastert, S. J., ten Cate, Rebecca, Hoppenreijs, Esther P. A. H., Armbrust, Wineke, Gorter, Simone L., van Pelt, Philomine A., Kamphuis, Sylvia S. M., Dolman, Koert M., Swart, Joost F., van den Berg, J. Merlijn, Koopman-Keemink, Yvonne, van Rossum, Marion A. J., Wulffraat, NM, and van Suijlekom-Smit, Lisette W. A.

Published
2015

18. Trends in prescription of biological agents and outcomes of juvenile idiopathic arthritis: results of the Dutch national Arthritis and Biologics in Children Register

Author

Arts-assistenten Kinderen, Reumatologie patientenzorg, Infection & Immunity, Child Health, Immuno/reuma patientenzorg, Otten, Marieke H., Anink, Janneke, Prince, Femke H. M., Twilt, Marinka, Vastert, S. J., ten Cate, Rebecca, Hoppenreijs, Esther P. A. H., Armbrust, Wineke, Gorter, Simone L., van Pelt, Philomine A., Kamphuis, Sylvia S. M., Dolman, Koert M., Swart, Joost F., van den Berg, J. Merlijn, Koopman-Keemink, Yvonne, van Rossum, Marion A. J., Wulffraat, NM, van Suijlekom-Smit, Lisette W. A., Arts-assistenten Kinderen, Reumatologie patientenzorg, Infection & Immunity, Child Health, Immuno/reuma patientenzorg, Otten, Marieke H., Anink, Janneke, Prince, Femke H. M., Twilt, Marinka, Vastert, S. J., ten Cate, Rebecca, Hoppenreijs, Esther P. A. H., Armbrust, Wineke, Gorter, Simone L., van Pelt, Philomine A., Kamphuis, Sylvia S. M., Dolman, Koert M., Swart, Joost F., van den Berg, J. Merlijn, Koopman-Keemink, Yvonne, van Rossum, Marion A. J., Wulffraat, NM, and van Suijlekom-Smit, Lisette W. A.

Published
2015

19. MRP8/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis

Author

Anink, Janneke, Smit, LWA, Otten, Marieke, Prince, Femke, van Rossum, MAJ, Dolman, KM, Hoppenreijs, EPAH, ten Cate, R (Rebecca), Ursu, S, Wedderburn, LR, Horneff, G, Frosch, M, Vogl, T, Gohar, F, Foell, D, Roth, J, Holzinger, D, Anink, Janneke, Smit, LWA, Otten, Marieke, Prince, Femke, van Rossum, MAJ, Dolman, KM, Hoppenreijs, EPAH, ten Cate, R (Rebecca), Ursu, S, Wedderburn, LR, Horneff, G, Frosch, M, Vogl, T, Gohar, F, Foell, D, Roth, J, and Holzinger, D

Published
2015

20. Two-year outcome of juvenile idiopathic arthritis in current daily practice: what can we tell our patients?

Author

Anink, Janneke, Dolman, Koert M., Merlijn van den Berg, J., van Veenendaal, Mira, Kuijpers, Taco W., van Rossum, Marion A. J., Other departments, Amsterdam institute for Infection and Immunity, and Paediatric Infectious Diseases / Rheumatology / Immunology

Abstract

Objectives This paper aims to evaluate disease course and outcome of patients in the first 2 years after diagnosis of juvenile idiopathic arthritis (JIA) when treated according to local standard of clinical care, focusing on achievement of inactive disease, functional ability and radiological joint damage. Methods A retrospective inception cohort study of children with JIA, diagnosed between January 2003 and June 2007 and treated in referral centres in Amsterdam, was carried out. Disease status was determined for every outpatient-clinic visit. Data regarding medication, functional outcome and radiography were recorded. Results One hundred and forty-nine consecutive newly diagnosed JIA patients were included. Median age at diagnosis was 11.8 years; median follow-up was 33 months. Synthetic DMARDs (sDMARDs) were used by 95% of patients, including methotrexate in 85%, sulfasalazine in 41% and biologics in 20%. sDMARDs were started within median 1 month after diagnosis. During follow-up, 77% of patients achieved a total of 244 episodes of inactive disease (ID). ID was reached after median 10 months. No baseline predictive factors for achievement of ID could be identified. After 2 years a median CHAQ score of 0.6 was reported. Radiological joint damage occurred at some point in 18 patients (12%); 10 of these patients developed erosions within median 20 months after their first clinic visit. Conclusion With current management strategies in daily clinical practice, 77% of newly diagnosed JIA patients achieved a first episode of inactive disease within a median of 10 months. After 2 years, patients reported moderate functional disability and more than 10% showed radiological evidence of joint damage

Published
2012

22. MRP8/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis

Author

Anink, Janneke, primary, Van Suijlekom-Smit, Lisette W. A., additional, Otten, Marieke H., additional, Prince, Femke H. M., additional, van Rossum, Marion A. J., additional, Dolman, Koert M., additional, Hoppenreijs, Esther P. A. H., additional, ten Cate, Rebecca, additional, Ursu, Simona, additional, Wedderburn, Lucy R., additional, Horneff, Gerd, additional, Frosch, Michael, additional, Vogl, Thomas, additional, Gohar, Faekah, additional, Foell, Dirk, additional, Roth, Johannes, additional, and Holzinger, Dirk, additional

Published
2015
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25. Long term functional outcome and quality of life of patients with refractory juvenile idiopathic arthritis treated with etanercept: results of the dutch arthritis and biologicals in children register

Author

Anink, Janneke, primary, Prince, Femke HM, additional, Dijkstra, Maryanne, additional, Otten, Marieke H, additional, Twilt, Marinka, additional, ten Cate, Rebecca, additional, Gorter, Simone L, additional, Koopman-Keemink, Yvonne, additional, van Rossum, Marion AJ, additional, Hoppenreijs, Esther PA, additional, and van Suijlekom-Smit, Lisette WA, additional

Published
2014
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27. Trends in prescription of biological agents and outcomes of juvenile idiopathic arthritis: results of the Dutch national Arthritis and Biologics in Children Register

Author

Otten, Marieke H, primary, Anink, Janneke, additional, Prince, Femke H M, additional, Twilt, Marinka, additional, Vastert, S J, additional, ten Cate, Rebecca, additional, Hoppenreijs, Esther P A H, additional, Armbrust, Wineke, additional, Gorter, Simone L, additional, van Pelt, Philomine A, additional, Kamphuis, Sylvia S M, additional, Dolman, Koert M, additional, Swart, Joost F, additional, van den Berg, J Merlijn, additional, Koopman-Keemink, Yvonne, additional, van Rossum, Marion A J, additional, Wulffraat, Nico M, additional, and van Suijlekom-Smit, Lisette W A, additional

Published
2014
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29. Effectiveness and safety of a second and third biological agent after failing etanercept in juvenile idiopathic arthritis: results from the Dutch National ABC Register

Author

Otten, Marieke H, primary, Prince, Femke H M, additional, Anink, Janneke, additional, ten Cate, Rebecca, additional, Hoppenreijs, Esther P A H, additional, Armbrust, Wineke, additional, Koopman-Keemink, Yvonne, additional, van Pelt, Philomine A, additional, Kamphuis, Sylvia, additional, Gorter, Simone L, additional, Dolman, Koert M, additional, Swart, Joost F, additional, van den Berg, J Merlijn, additional, Wulffraat, Nico M, additional, van Rossum, Marion A J, additional, and van Suijlekom-Smit, Lisette W A, additional

Published
2012
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32. A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities

Author

Beukelman, Timothy, Anink, Janneke, Berntson, Lillemor, Duffy, Ciaran, Ellis, Justine A, Glerup, Mia, Guzman, Jaime, Horneff, Gerd, Kearsley-Fleet, Lianne, Klein, Ariane, Klotsche, Jens, Magnusson, Bo, Minden, Kirsten, Munro, Jane E, Niewerth, Martina, Nordal, Ellen, Ruperto, Nicolino, Santos, Maria J, Schanberg, Laura E, Thomson, Wendy, Van Suijlekom-Smit, Lisette, Wulffraat, Nico, and Hyrich, Kimme

Subjects
10. No inequality, 3. Good health
Abstract

Background: To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration. Methods: We surveyed investigators from North America, Europe, and Australia about existing JIA cohort studies and registries. We excluded cross-sectional studies. We captured information about study design, duration, location, inclusion criteria, data elements and collection methods. Results: We received survey results from 18 studies, including 11 national and 7 multi-national studies representing 37 countries in total. Study designs included inception cohorts, prevalent disease cohorts, and new treatment cohorts (several of which contribute to pharmacosurveillance activities). Despite numerous differences, the data elements collected across the studies was quite similar, with most studies collecting at least 5 of the 6 American College of Rheumatology core set variables and the data needed to calculate the 3-variable clinical juvenile disease activity score. Most studies were collecting medication initiation and discontinuation dates and were attempting to capture serious adverse events. Conclusion: There is a wide-range of large, ongoing JIA registries and cohort studies around the world. Our survey results indicate significant potential for future collaborative work using data from different studies and both combined and comparative analyses.

33. Two-year outcome of juvenile idiopathic arthritis in current daily practice: what can we tell our patients?

Author

Anink J, Dolman KM, Merlijn van den Berg J, van Veenendaal M, Kuijpers TW, and van Rossum MA

Subjects
Adolescent, Antirheumatic Agents adverse effects, Arthritis, Juvenile diagnostic imaging, Arthritis, Juvenile physiopathology, Arthrography, Chi-Square Distribution, Child, Disability Evaluation, Female, Humans, Joints pathology, Logistic Models, Male, Netherlands, Predictive Value of Tests, Recovery of Function, Remission Induction, Retrospective Studies, Severity of Illness Index, Standard of Care, Time Factors, Treatment Outcome, Antirheumatic Agents therapeutic use, Arthritis, Juvenile drug therapy, Joints drug effects
Abstract

Objectives: This paper aims to evaluate disease course and outcome of patients in the first 2 years after diagnosis of juvenile idiopathic arthritis (JIA) when treated according to local standard of clinical care, focusing on achievement of inactive disease, functional ability and radiological joint damage., Methods: A retrospective inception cohort study of children with JIA, diagnosed between January 2003 and June 2007 and treated in referral centres in Amsterdam, was carried out. Disease status was determined for every outpatient-clinic visit. Data regarding medication, functional outcome and radiography were recorded., Results: One hundred and forty-nine consecutive newly diagnosed JIA patients were included. Median age at diagnosis was 11.8 years; median follow-up was 33 months. Synthetic DMARDs (sDMARDs) were used by 95% of patients, including methotrexate in 85%, sulfasalazine in 41% and biologics in 20%. sDMARDs were started within median 1 month after diagnosis. During follow-up, 77% of patients achieved a total of 244 episodes of inactive disease (ID). ID was reached after median 10 months. No baseline predictive factors for achievement of ID could be identified. After 2 years a median CHAQ score of 0.6 was reported. Radiological joint damage occurred at some point in 18 patients (12%); 10 of these patients developed erosions within median 20 months after their first clinic visit., Conclusions: With current management strategies in daily clinical practice, 77% of newly diagnosed JIA patients achieved a first episode of inactive disease within a median of 10 months. After 2 years, patients reported moderate functional disability and more than 10% showed radiological evidence of joint damage.

Published
2012

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