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This paper aims to improve the design of a seat slider mechanism for an automotive seating system. The seating track mechanism comprises various parts, such as the track bar, upper slider rail, lower slider rail, and locking/unlocking mechanism. The upper rail holds the seat and manikin weight, whereas the lower rail is secured with mounting brackets. A Computer-aided design model of the proposed modified locking/unlocking mechanism of the seating track is created and conducted Finite Element Analysis (FEA). Also, the study includes the motion and dynamic analysis of the seating track mechanism using the bond graph technique by considering the mechanism with an equivalent spring-mass-damper system. The FEA ensured the design strength and its safety regarding failure analysis, whereas the motion analysis confirmed the suitability of the mechanism's kinematics. It is found that the maximum stress is developed at the track bar, i.e., 186.35 MPa, whereas the track displacement reaches its final design position, i.e., 175 mm in 2 s, when the applied force on the track bar is 100 N and on each slider is 20 N. The study ensures an alternative spring-less locking/unlocking mechanism for the seat slider mechanism.

This work deals with the explicit dynamic frontal crash analysis of the roll cage of an All-Terrain Vehicle. The crash testing analysis is done to ensure the safety of the driver during an accident in a catastrophic event. A roll cage model of the All-Terrain Vehicle is developed as per the rules laid down by BAJA SAE INDIA for m-BAJA vehicles using SolidWorks. Thereafter, the dynamic frontal crash analysis is performed by making a collision with a rigid wall, keeping a uniform velocity of the roll cage is 40 km/h. The analysis is carried out in HyperWorks software using Radioss solver. The work established the driver safety for the proposed roll cage by analyzing the stress development, and the total deformation after the collision. It is found that Von Mises stresses of the roll cage model except a joint of Side Impact Member is lower than the permissible limit.

Soil organic and inorganic carbon (SOC & SIC) and microbial community structure are key indicators of soil quality and productivity in arid-saline soils. Salinity stress and diminishing availability of freshwater (FW) for irrigation are major constraints for productivity and improving soil quality indicators. Using treated wastewater (TW) and implementing climate-smart cropping systems are promising alternatives to replace freshwater usage in intensive cropping systems, however, impacts on the microbial community and net-carbon sequestration potential are not clearly understood. This field study was conducted in an arid saline-soil to investigate soil microbial community structure and soil carbon contents under a combination of treatments comparing bioenergy sorghum (So) and switchgrass (Sg), two irrigation water sources (FW & TW), and gypsum amendment (GA), to a native-soil control. After three years of implementing these treatments, soil samples were collected and analyzed for total carbon (TC), SOC, SIC, microbial biomass-carbon (MBC) and microbial community structure. Results showed that TW increased microbial diversity and shifted the community structure towards copiotroph-dominated prokaryotes. Several predominant and responsive taxa were associated with divergent trends of SOC, SIC and salinity parameters. Both SOC and SIC pools were sensitive to treatments and demonstrated divergent trends, as contents of TC and SOC were higher in TW-treatments, but of SIC were significantly lower in several So_TW treatments. Treatment TW_So_GA assembled a distinctive microbial community structure, accumulated the highest content of SOC (7.66 g kg−1) but recorded the lowest content of SIC (6.63 g kg−1). The lowest content of SOC was observed in native soil (4.58 g kg−1) but contained the highest SIC (8.15 g kg−1). The study results revealed the agronomic systems with higher potential for increasing TC and SOC content in arid-saline soils. Surface soil SIC was responsive to agronomic management, and several treatments produced disparate impacts on SOC and SIC stocks, which warrant for considering TC as the key indicator for assessing carbon sequestration in arid lands.

Soil is a vital component of the ecosystem that drives the holistic homeostasis of the environment. Directly, soil quality and health by means of sufficient levels of soil nutrients are required for sustainable agricultural practices for ideal crop yield. Among these groups of nutrients, soil carbon is a factor which has a dominating effect on greenhouse carbon phenomena and thereby the climate change rate and its influence on the planet. It influences the fertility of soil and other conditions like enriched nutrient cycling and water retention that forms the basis for modern ‘regenerative agriculture’. Implementation of soil sensors would be fundamentally beneficial to characterize the soil parameters in a local as well as global environmental impact standpoint, and electrochemistry as a transduction mode is very apt due to its feasibility and ease of applicability. Organic Matter present in soil (SOM) changes the electroanalytical behavior of moieties present that are carbon-derived. Hence, an electrochemical-based ‘bottom-up’ approach is evaluated in this study to track soil organic carbon (SOC). As part of this setup, soil as a solid-phase electrolyte as in a standard electrochemical cell and electrode probes functionalized with correlated ionic species on top of the metalized electrodes are utilized. The surficial interface is biased using a square pulsed charge, thereby studying the effect of the polar current as a function of the SOC profile. The sensor formulation composite used is such that materials have higher capacity to interact with organic carbon pools in soil. The proposed sensor platform is then compared against the standard combustion method for SOC analysis and its merit is evaluated as a potential in situ, on-demand electrochemical soil analysis platform.

The volumetric rate of tidal disruption events (TDEs) encodes information on the still-unknown demographics of central massive black holes (MBHs) in low-mass galaxies (≲10 ^9 M _⊙ ). Theoretical TDE rates from model galaxy samples can extract this information, but this requires accurately defining the nuclear stellar density structures. This region is typically dominated by nuclear star clusters (NSCs), which have been shown to increase TDE rates by orders of magnitude. Thus, we assemble the largest available sample of parsec-scale 3D density profiles that include NSC components. We deproject the point-spread-function-deconvolved surface-brightness profiles of 91 nearby galaxies of varying morphology and combine these with nuclear mass-to-light ratios estimated from measured colors or spectral synthesis to create 3D mass density profiles. We fit the inner 3D density profile to find the best-fit power-law density profile in each galaxy. We compile this information as a function of galaxy stellar mass to fit new empirical density scaling relations. These fits reveal positive correlations between galaxy stellar mass and central stellar density in both early- and late-type galaxies. We find that early-type galaxies have somewhat higher densities and shallower profiles relative to late-type galaxies at the same mass. We also use the density profiles to estimate the influence radius of each galaxy’s MBH and find that the sphere of influence was likely resolved in most cases. These new relations will be used in future works to build mock galaxy samples for dynamical TDE rate calculations, with the aim of constraining MBH demographics in low-mass galaxies.

We measure the high-mass stellar initial mass function (IMF) from resolved stars in M33 young stellar clusters. Leveraging the Hubble Space Telescope’s high resolving power, we fully model the IMF probabilistically. We first model the optical color–magnitude diagram of each cluster to constrain its power-law slope Γ, marginalized over other cluster parameters in the fit (e.g., cluster age, mass, and radius). We then probabilistically model the distribution of mass function (MF) slopes for a highly strict cluster sample of nine clusters more massive than log(Mass/ M _⊙ ) = 3.6; above this mass, all clusters have well-populated main sequences of massive stars and should have accurate recovery of their MF slopes, based on extensive tests with artificial clusters. We find that the ensemble IMF is best described by a mean high-mass slope of $\overline{{\rm{\Gamma }}}=1.49\pm 0.18$ , with an intrinsic scatter of ${\sigma }_{{\rm{\Gamma }}}^{2}={0.02}_{0.00}^{+0.16}$ , consistent with a universal IMF. We find no dependence of the IMF on environmental impacts such as the local star formation rate (SFR) or galactocentric radius within M33, which serves as a proxy for metallicity. This $\overline{{\rm{\Gamma }}}$ measurement is consistent with similar measurements in M31, despite M33 having a much higher SFR intensity. While this measurement is formally consistent with the canonical Kroupa (Γ = 1.30) IMF, as well as the Salpeter (Γ = 1.35) value, it is the second Local Group cluster sample to show evidence for a somewhat steeper high-mass IMF slope. We explore the impacts a steeper IMF slope has on a number of astronomical subfields.

We have conducted a systematic search around the Milky Way (MW) analog NGC 253 ( D = 3.5 Mpc), as a part of the Panoramic Imaging Survey of Centaurus and Sculptor (PISCeS)—a Magellan+Megacam survey to identify dwarfs and other substructures in resolved stellar light around MW-mass galaxies outside of the Local Group. In total, NGC 253 has five satellites identified by PISCeS within 100 kpc with an absolute V -band magnitude of M _V < −7. We have additionally obtained deep Hubble Space Telescope imaging of four reported candidates beyond the survey footprint: Do III, Do IV, and dw0036m2828 are confirmed to be satellites of NGC 253, while SculptorSR is found to be a background galaxy. We find no convincing evidence for the presence of a plane of satellites surrounding NGC 253. We construct its satellite luminosity function, which is complete down to M _V ≲ −8 out to 100 kpc and M _V ≲ −9 out to 300 kpc, and compare it to those calculated for other Local Volume galaxies. Exploring trends in satellite counts and star-forming fractions among satellite systems, we find relationships with host stellar mass, environment, and morphology, pointing to a complex picture of satellite formation, and a successful model has to reproduce all of these trends.

We combine archival Hubble Space Telescope and new James Webb Space Telescope imaging data covering the ultraviolet to mid-infrared regime to morphologically analyze the nuclear star cluster (NSC) of NGC 628, a grand-design spiral galaxy. The cluster is located in a 200 pc × 400 pc cavity lacking both dust and gas. We find roughly constant values for the effective radius ( r _eff ∼ 5 pc) and ellipticity ( ϵ ∼ 0.05), while the Sérsic index ( n ) and position angle (PA) drop from n ∼ 3 to ∼2 and PA ∼ 130° to 90°, respectively. In the mid-infrared, r _eff ∼ 12 pc, ϵ ∼ 0.4, and n ∼ 1–1.5, with the same PA ∼ 90°. The NSC has a stellar mass of ${\mathrm{log}}_{10}\,({M}_{\star }^{\mathrm{nsc}}/{M}_{\odot })=7.06\pm 0.31$ , as derived through B − V , confirmed when using multiwavelength data, and in agreement with the literature value. Fitting the spectral energy distribution (SED), excluding the mid-infrared data, yields a main stellar population age of (8 ± 3) Gyr with a metallicity of Z = 0.012 ± 0.006. There is no indication of any significant star formation over the last few gigayears. Whether gas and dust were dynamically kept out or evacuated from the central cavity remains unclear. The best fit suggests an excess of flux in the mid-infrared bands, with further indications that the center of the mid-infrared structure is displaced with respect to the optical center of the NSC. We discuss five potential scenarios, none of them fully explaining both the observed photometry and structure.

Purpose Blood is one of the most important connective tissues of human body. Bloodstream infection can range from inapparent bacteremia till fulminant septic shock with high mortality. Presence of microbes in blood whether continuously, intermittently, or transiently is a grave risk to every organ of body. Culture of blood is a vital tool to diagnose such infections. Drug susceptibility patterns help in rationalizing therapy. Objective The aim of the study is to perform bacteriological analysis and assess drug sensitivity patterns of blood culture isolates and compare in light of other associated variables. Design Retrospective observational study was conducted from January 2009 to December 2013 at a tertiary care hospital at Shillong, India. Blood samples were collected with aseptic guidelines and cultured for 7 days. Growths were identified by standard biochemical tests and subjected to sensitivity testing according to Modified Kirby Bauer disk diffusion method. Data for source of blood collection and duration of incubation were noted and compared. Results A total of 658 (11.2%) pathogens were isolated from 5,867 bacteremia-suspected patient blood specimens. Contamination was observed at the rate of 1.21%. Gram-negative organisms were the predominant pathogens recovered, Klebsiella pneumoniae being the most common. No significant difference was observed between the number of organisms isolated within or beyond 48 hours. Acinetobacter baumannii and K. pneumoniae have significantly higher chances (p < 0.05) of isolation from central line catheters compared with peripheral venipuncture. Conclusion Successful treatment of sepsis depends on early diagnosis and proper antimicrobial therapy. Local knowledge of bacteriological profile and antimicrobial sensitivity patterns helps rationalize empiric treatment strategies.

We assemble a catalog of 15424 nearby galaxies within 50 Mpc with consistent and homogenized mass, distance, and morphological type measurements. Our catalog combines galaxies from HyperLeda, the NASA-Sloan Atlas, and the Catalog of Local Volume Galaxies. Distances for the galaxies combine best-estimates for flow-corrected redshift-based distances with redshift-independent distances. We also compile magnitude and color information for 11740 galaxies. We use the galaxy colors to estimate masses by creating self-consistent color—mass-to-light ratio relations in four bands; we also provide color transformations of all colors into Sloan g – i by using galaxies with overlapping color information. We compile morphology information for 13744 galaxies, and use the galaxy color information to separate early- and late-type galaxies. This catalog is widely applicable for studies of nearby galaxies and for placing these studies in the context of more distant galaxies. We present one application here: a preliminary analysis of the nuclear X-ray activity of galaxies. Out of 1506 galaxies within the sample that have available Chandra X-ray observations, we find that 291 have detected nuclear sources. Of the 291 existing Chandra detections, 249 have log( L _X ) > 38.3 and available stellar mass estimates. We find that the X-ray active fractions in early-type galaxies are higher than in late-type galaxies, especially for galaxy stellar masses between 10 ^9 and 10 ^10.5 M _⊙ . We show that these differences may be due at least in part to the increased astrometric uncertainties in late-type galaxies relative to early types.

We present a new approach to measuring the thickness of a partially face-on stellar disk, using dust geometry. In a moderately-inclined disk galaxy, the fraction of reddened stars is expected to be 50% everywhere, assuming that dust lies in a thin midplane. In a thickened disk, however, a wide range of radii project onto the line of sight. Assuming stellar density declines with radius, this geometrical projection leads to differences in the numbers of stars on the near and far sides of the thin dust layer. The fraction of reddened stars will thus differ from the 50% prediction, with a deviation that becomes larger for puffier disks. We map the fraction of reddened red giant branch (RGB) stars across M31, which shows prominent dust lanes on only one side of the major axis. The fraction of reddened stars varies systematically from 20% to 80%, which requires that these stars have an exponential scale height h _z that is 0.14 ± 0.015 times the exponential scale length ( h _r ≈ 5.5 kpc). M31's RGB stars must therefore have h _z = 770 ± 80 pc, which is far thicker than the Milky Way’s thin disk, but comparable to its thick disk. The lack of a significant thin disk in M31 is unexpected, but consistent with its interaction history and high disk velocity dispersion. We suggest that asymmetric reddening be used as a generic criterion for identifying “thick disk”-dominated systems, and discuss prospects for future 3D tomographic mapping of the gas and stars in M31.

Arsenic (As) bioavailability in the rice rhizosphere is influenced by many microbial interactions, particularly by metal-transforming functional groups at the root-soil interface. This study was conducted to examine As-transforming microbes and As-speciation in the rice rhizosphere compartments, in response to two different water management practices (continuous and intermittently flooded), established on fields with high to low soil-As concentration. Microbial functional gene composition in the rhizosphere and root-plaque compartments were characterized using the GeoChip 4.0 microarray. Arsenic speciation and concentrations were analyzed in the rhizosphere soil, root-plaque, pore water, and grain samples. Results confirmed several As-biotransformation processes in the rice rhizosphere compartments, and distinct assemblage of As-reducing and methylating bacteria was observed between the root-plaque and rhizosphere. Results confirmed higher potential for microbial As-reduction and As-methylation in continuously flooded, long term As-contaminated fields, which accumulated highest concentrations of AsIII and methyl-As concentrations in pore water and rice grains. Water management treatment significantly altered As-speciation in the rhizosphere, and intermittent flooding reduced methyl-As and AsIII concentrations in the pore water, root-plaque and rice grain. Ordination and taxonomic analysis of detected gene-probes indicated that root-plaque and rhizosphere assembled significantly different microbial functional groups demonstrating niche separation. Taxonomic non-redundancy was evident, suggesting that As-reduction, -oxidation and -methylation processes were performed by different microbial functional groups. It was also evident that As transformation was coupled to different biogeochemical cycling processes (nutrient assimilation, carbon metabolism etc.) in the compartments and between treatments, revealing functional non-redundancy of rice-rhizosphere microbiome in response to local biogeochemical conditions and As contamination. This study provided novel insights on As-biotransformation processes and their implications on As-chemistry at the root-soil interface and their responses to water management, which could be applied for mitigating As-bioavailability and accumulation in rice grains.

Objective: To detect the prevalence pattern of Chikungunya virus in three states of Northeast India. Methods: A total of 1 510 samples were collected from different private and government hospitals of Assam, Arunachal Pradesh and Meghalaya. Serum was tested for the presence of IgM antibodies against Chikungunya virus followed by RT-PCR for amplification of Chikungunya E1 gene region using specific primers. Results: Overall, 11.83% (172/1 454) clinical samples were positive by MAC-ELISA and/or RT-PCR assay. Asymptomatic infection was seen in 17.86%. Males were more affected than females and age group 16-30 years was mostly affected. Fever (100.00%) was the primary symptom followed by headache (72.03%) and arthralgia (41.53%). Only 118 Chikungunya positive cases could be traced, of which 25.42% complained about sequelae of infection. In entomological investigation, Aedes aegypti was more predominant (92.10%) than Aedes albopictus (7.90%). No mosquito pools could be incriminated for Chikungunya virus. Conclusions: In this study, Chikungunya was observed to be prevalent in Assam, Arunachal Pradesh and Meghalaya. Though Chikungunya is a self-limiting infection, increasing morbidity by CHIKV infection is affecting social and economic status of individual. Thus, a community empowerment to effectively control mosquito population by employing different mosquito control measures along with personal protection is mandatory to tackle future outbreak of the disease.

In the present research, the selective oxidation of lauryl alcohol to lauraldehyde was studied under liquid-liquid phase transfer conditions using potassium chromate (K2CrO4) as an oxidizing agent and tetrabutyl ammonium bromide (TBAB) as the phase transfer catalyst. Chromium (VI) reagents are used in these oxidations since the alcohols are selectively oxidized to the aldehydes without any over-oxidation. In non-aqueous solutions the oxidation by chromium (VI) does not go to completion as the intermediate partially oxidized material containing chromium must be hydrolysed for oxidation to continue. Liquid-Liquid Phase Transfer Catalysis (LL-PTC) involves the transfer of one reactant from the aqueous phase to the organic phase with the help of small quantities of a phase transfer catalyst which is usually quaternary ammonium or phosphonium salt. It was observed that no over-oxidation products such as lauric acid and high molecular weight esters of lauryl alcohol were formed under the reaction conditions used. The effect of various reaction parameters such as the speed of agitation, temperature, the concentration of lauryl alcohol, the concentration of potassium chromateand phase transfer catalyst loading were studied. A reaction mechanism involving the formation of chromate ester in the organic phase has been proposed and a kinetic model has been developed based on the experimental results obtained.

The aim of this research work is to investigate the efficiency of newly developed Natural Fiber Rope Reinforced Polymer (NFRRP) composites to enhance the shear strength of reinforced concrete (RC) beams. Two types of NFRRP composites were made using low-cost hemp and cotton fiber ropes. The effectiveness of this NFRRP confinement in increasing the shear, energy dissipation, and deformation capacities of concrete beams was studied. The effect of these natural fiber ropes with different configurations on beams was investigated. The responses of seven RC beams with different spacing arrangements of natural fiber ropes were evaluated in terms of shear enhancement, deflection, energy dissipation capacity, effect of strengthening configuration, rope types, and ultimate failure modes. The NFRRP composites exceptionally enhanced the load carrying abilities, energy dissipation, and deformation capabilities of RC beams as compared to the control beam. The ultimate load carrying capacities of natural hemp and cotton Fiber Rope Reinforced Polymer (FRRP) composite confined beams were found to be 63% and 56% higher than that of the control beam, respectively. Thus, the shear strengthening of RC beams using natural fiber ropes is found to be an effective technique. Finite Element Analysis was also carried out by using the Advanced Tool for Engineering Nonlinear Analysis (ATENA) software. The analysis results compare favorably with the tests’ results.

Spectral floor-acceleration demands are necessary for the seismic design of acceleration-sensitive non-structural components (NSCs). Existing studies to estimate floor response spectra (FRS) using empirical equations are based on elasto-plastic and stiffness degrading hysteretic behavior of the primary structure. In the present study, the FRS for self-centering (SC) structural systems with flag-shaped hysteretic behavior under far-fault ground motions are investigated. The FRS and dynamic amplification factor (DAF) are obtained from nonlinear response history analysis (NLRHA) of SC structural systems with flag-shaped hysteretic behavior. An equation to estimate the FRS is proposed and verified by carrying out NLRHA using a different set of far-fault ground motions. The equation to estimate FRS is shown to predict floor acceleration demands with very good accuracy.

Background: Tuberculosis is a common cause of pleural effusion in countries like India where it is highly endemic. The biochemical markers are more sensitive and reliable in the diagnosis of pleural tuberculosis. Objectives: The present study was aimed to evaluate the diagnostic potential of pleural adenosine deaminase levels in tubercular pleural effusion. Materials and Methods: The study is a clinical, prospective and observational of 50 patients of pleural effusion consecutively admitted in the medical wards. Detailed history, thorough physical examination, radiological findings, haematological and biochemical findings were recorded in the proforma. Pleural aspiration was performed on all patients. Macroscopic findings, cytological, microbiological and biochemical analysis of pleural fluid were performed in all patients including pleural adenosine deaminase level. Results: Mean age group of tubercular effusion was 26-55 years and common in men. Out of 31 tubercular effusion patients, 29 (93.33%) were showed pleural adenosine deaminase level more than 40IU/L. pleural adenosine deaminase estimation showed 93.3% sensitivity and 90% specificity, 93.3% positive predictive value and 90% negative predictive value. Mean pleural adenosine deaminase level (IU/L) in tubercular, synpneumonic and transudative effusions were 70.36±26.48, 17.46±4.31 and 11.58±2.35 respectively. Conclusions: Pleural adenosine deaminase estimation seems to have the potential for being one of safe, simple, reliable and noninvasive marker which is adequately sensitive and specific in distinguishing tubercular and non tubercular effusion.

This research investigates the behavior of square concrete columns externally wrapped by low-cost and easily available fiber rope reinforced polymer (FRRP) composites. This study mainly aims to explore the axial stress-strain relationships of FRRP-confined square columns. Another objective is to assess suitable predictive models for the ultimate strength and strain of FRRP-confined square columns. A total of 60 square concrete columns were cast, strengthened, and tested under compression. The parameters were the corner radii of square columns (0, 13, and 26 mm) and different materials of FRRP composites (polyester, hemp, and cotton FRRP composites). The strength and deformability of FRRP-confined specimens were observed to be higher than the unconfined specimens. It was observed that strength gains of FRRP-confined concrete columns and corner radii were directly proportional. The accuracy of ultimate strength and strain models developed for synthetic FRRP-confined square columns was assessed using the test results of this study, showing the need for the development of improved predictive models for FRRP-confined square columns. Newly developed unified models were found to be accurate in predicting the ultimate strength and strain of FRRP-confined columns.

An efficient and scalable method for the direct isolation of stable α-form crystals of mirabegron (1) is developed. The developed method negates transformation of metastable β-form crystals into α-form crystals thereby overcome the limitations of reported methods and avoids additional processing steps during its manufacture. The developed method directly provides stable α-form crystals of Mirabegron (1) with yield of around 84 % and purity of >99.77% by HPLC in a single step.

Flash pulmonary edema (FPE) is a rare clinical presentation of renal artery stenosis. It is an episode of abrupt onset pulmonary edema that resolves rapidly. It occurs in patients with bilateral renal artery stenosis or unilateral renal artery stenosis with a solitary functioning kidney. We report a patient of diabetic end-stage renal disease on maintenance hemodialysis who manifested FPE on a few occasions which responded to renal revascularization. The indications of renal revascularization have been narrowed to poor blood pressure control, when progressive loss of renal function is encountered, or when circulatory congestion is a prominent feature.

BACKGROUND: Anemia is a major public health problem among reproductive-aged women in India. Despite many programs implemented for decades to fight anemia, still the prevalence of anemia is high because its associated factors vary among different regions. This exploratory study was carried out to find the prevalence of anemia and factors influencing it among nonpregnant reproductive-aged women (15–49 years) in a rural area of Coimbatore. MATERIALS AND METHODS: The study was conducted in the field practice area of Rural Health Training Centre, PSG IMSR, Coimbatore, during March 2016 to August 2016. Participants were recruited by two-staged random sampling method and 426 participants were enrolled. A predesigned semi-structured questionnaire was used to collect the data pertaining to the factors influencing the prevalence of anemia, and their hemoglobin level was measured using a hemoglobin photometer. The data were analyzed using SPSS-24. (IBM Corporation, SPSS Inc., Chicago, IL, USA) Univariate analysis was done using Chi-square test and the strength of association was estimated by odds ratio. Those factors which were found to be significant by univariate analysis were further subjected to multivariate logistic regression analysis. P < 0.05 was considered statistically significant. RESULTS: The prevalence of anemia was estimated as 64.8% (95% confidence interval: 60%–69%). Significant predictors for anemia among the study participants were less frequent intake of green leafy vegetables (adjusted odds ratio [AOR] = 3.65, confidence interval [CI]: 2.17–6.12), low socioeconomic status (AOR = 3.36, CI: 1.93–5.84), illiteracy (AOR = 3.09, CI: 1.09–5.24), birth spacing

Objectives: Sickle cell disease (SCD) is a global health concern associated with high childhood morbidity and mortality; in Oman, the prevalence of SCD is 0.2%. Public awareness of SCD and the need for premarital screening (PMS) are essential to reduce the incidence of this disease. This study aimed to assess awareness of and beliefs regarding SCD and PMS among Omanis in a primary healthcare setting. Methods: This cross-sectional study took place in five health centres located in Al-Seeb Province, Muscat, Oman, between June and August 2015. A total of 500 Omanis aged ≥18 years old attending the clinics were invited to participate in the study. A previously described questionnaire by Gustafson et al. was used to measure awareness of and beliefs regarding SCD and PMS. Results: A total of 450 Omani adults completed the questionnaire (response rate: 90.0%). The majority (67.8%) were aware that SCD is genetically inherited and 85.1% believed in the value of PMS; however, only 24.4% reported having undergone PMS previously. Few participants were aware that SCD can be very painful (20.2%) and can cause strokes, infections and organ damage (20.0%). More than half (56.7%) reported that the availability of educational material on SCD or PMS in Oman was inadequate. Participants’ education levels were positively associated with accurate SCD knowledge (P

Real-time monitoring of speech quality for VoIP calls is a significant challenge. This paper presents early work on a no-reference objective model for quantifying perceived speech quality in VoIP. The overall approach uses a modular design that will be able to help pinpoint the reason for degradations as well as quantifying their impact on speech quality. The model is being designed to work with narrowband and wideband signals. This initial work is focused on rating amplitude clipped or chopped speech, which are common problems in VoIP. A model sensitive to each of these degradations is presented and then tested with both synthetic and real examples of chopped and clipped speech. The results were compared with predicted MOS outputs from four objective speech quality models: ViSQOL, PESQ, POLQA and P.563. The model output showed consistent relationships between this model's clip and chop detection modules and the quality predictions from the other objective speech quality models. Further work is planned to widen the range of degradation types captured by the model, such as non-stationary background noise and speaker echo. While other components (e.g. a voice activity detector) would be necessary to deploy the model for stand-alone VoIP monitoring, the results show good potential for using the model in a realtime monitoring tool.

Objective: To find an anthropometric indicator that can effectively be associated with Non Alcoholic Fatty Liver Disease (NAFLD). Materials and Methods: This cross sectional study was conducted in PSGIMSR, Coimbatore. A total of 108 subjects were recruited, of whom 57 were diagnosed as NAFLD and 51 as non-NAFLD (control group).The height, body weight, waist and hip circumference were measured, and body mass index (BMI), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHR) were calculated. Statistical Analysis: Chi-Square test and t-test were employed to assess the statistical significance in qualitative and quantitative data respectively. Multivariate logistic regression analysis was performed to investigate the association between suspected anthropometric risk factors and NAFLD. The anthropometric risk factors considered were adjusted for Age and Gender and BMI, WHR, WHtR were converted into categorical variables. To rank their discriminatory power Area Under Receiver Operating Characteristic analysis was done. Results: Compared to control group, BMI and WHtR were statistically higher in patients with NAFLD whereas no significant difference was observed in WHR. Logistic regression analysis showed BMI (Odds Ratio (OR) = 6.45, 95% CI; 1.98, .20.99) and WHtR (OR = 4.84, 95% CI 1.24, 18.87) were the two effective indicators associated with NAFLD. BMI had more discriminatory power than WHtR in predicting NAFLD. Conclusion: We conclude that BMI and WHtR are better anthropometric measure associated with NAFLD.

Objectives: Studies of parental atopy, exposure to pets, and the risk of asthma have provided conflicting results. We aimed to assess the relationship between asthma among adults with parental atopy, pet keeping inside, and pet keeping outside the home. This study involved a total of 159 adults. The clinically diagnosed cases were 53 adults with asthma as per Global Initiative for Asthma (GINA) guidelines and 106 controls without asthma. Methods: The study design was a hospital based case-control study. Information on parental atopy and exposure to pets was collected by using a self-administrated questionnaire. We used the exposure odds ratio and 95% confidence interval (CI) to quantify the relation between determinants of interest and the risk of asthma. These were estimated using logistic regression analysis with SPSS version 11.5. Results: The paternal and maternal history of asthma were found to have significant effect on asthma among adults with adjusted odds ratio (OR) of 6.70 (1.92-23.33 95%CI) and 3.33 (1.25-8.89 95% CI) respectively. Parental history and parental atopy significantly increased risk of asthma among adults with adjusted odds ratios of 5.78 (2.38-14.05 95% CI) and 3.65 (1.58-8.43 95% CI) respectively. There was no significant association between asthma and exposure to pets. The adjusted odds ratios for pet keeping inside and outside the house were 1.61 (0.55-4.7395%CI) and 1.32 (0.61-2.87 95%CI) respectively. Conclusions: Our results support the hypothesis that both parental history and parental atopy increase the risk of asthma among adults whereas pet keeping inside and outside the house during the previous 12-month period were not significantly associated with asthma among adults.

The meals from many oilseed crops have potential for biofumigation due to their release of biocidal compounds such as isothiocyanates (ITCs). Various ITCs are known to inhibit numerous pathogens; however, much less is known about how the soil microbial community responds to the different types of ITCs released from oilseed meals (SMs). To simulate applying ITC-releasing SMs to soil, we amended soil with 1% flax SM (contains no biocidal chemicals) along with four types of ITCs (allyl, butyl, phenyl, and benzyl ITC) in order to determine their effects on soil fungal and bacterial communities in a replicated microcosm study. Microbial communities were analyzed based on the ITS region for fungi and 16S rRNA gene for bacteria using qPCR and tag-pyrosequencing with 454 GS FLX titanium technology. A dramatic decrease in fungal populations (~85% reduction) was observed after allyl ITC addition. Fungal community compositions also shifted following ITC amendments (e.g., Humicola increased in allyl and Mortierella in butyl ITC amendments). Bacterial populations were less impacted by ITCs, although there was atransient increase in the proportion of Firmicutes, related to bacteria know to be antagonistic to plant pathogens, following amendment with allyl ITC. Our results indicate that the type of ITC released from SMs can result in differential impacts on soil microorganisms. This information will aid selection and breeding of plants for biofumigation-based control of soil-borne pathogens while minimizing the impacts on non-target microorganisms.

The use of adaptive design methods in clinical research has become popular due to its flexibility. Such methods are very useful in early clinical development. Urn designs and covariate-adaptive designs are specific adaptive designs aimed at balancing the treatment groups in a clinical trial. In this article, we provide a comprehensive review of adaptive design methods in clinical research and development.

Microbial reduction of toxic hexavalent chromium (Cr(VI)) in-situ is a plausible bioremediation strategy in electron-acceptor limited environments. However, higher [Cr(VI)] may impose stress on syntrophic communities and impact community structure and function. The study objectives were to understand the impacts of Cr(VI) concentrations on community structure and on the Cr(VI)-reduction potential of groundwater communities at Hanford, WA. Steady state continuous flow bioreactors were used to grow native communities enriched with lactate (30 mM) and continuously amended with Cr(VI) at 0.0 (No-Cr), 0.1 (Low-Cr) and 3.0 (High-Cr) mg/L. Microbial growth, metabolites, Cr(VI), 16S rRNA gene sequences and GeoChip based functional gene composition were monitored for 15 weeks. Temporal trends and differences in growth, metabolite profiles, and community composition were observed, largely between Low-Cr and High-Cr bioreactors. In both High-Cr and Low-Cr bioreactors, Cr(VI) levels were below detection from week 1 until week 15. With lactate enrichment, native bacterial diversity substantially decreased as Pelosinus spp., and Sporotalea spp., became the dominant groups, but did not significantly differ between Cr concentrations. The Archaea diversity also substantially decreased after lactate enrichment from Methanosaeta (35%), Methanosarcina (17%) and others, to mostly Methanosarcina spp. (95%). Methane production was lower in High-Cr reactors suggesting some inhibition of methanogens. Several key functional genes were distinct in Low-Cr bioreactors compared to High-Cr. Among the Cr resistant microbes, Burkholderia vietnamiensis, Comamonas testosterone and Ralstonia pickettii proliferated in Cr amended bioreactors. In-situ fermentative conditions facilitated Cr(VI) reduction, and as a result 3.0 mg/L Cr(VI) did not impact the overall bacterial community structure.