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7. One-year readmissions for circulatory diseases and in-hospital mortality after an index episode of heart failure in elderly patients. A nationwide data from public hospitals in Spain between 2016 and 2018

Author

Esteban-Fernández, Alberto, Anguita-Sánchez, Manuel, Bonilla-Palomas, Juan Luis, Anguita-Gámez, María, Rosillo, Nicolás, del Prado, Náyade, Bernal, José Luis, Fernández-Pérez, Cristina, Fernández-Rozas, Inmaculada, Gómez-Doblas, Juan José, Pérez-Villacastin, Julián, and Elola, Francisco Javier

Published
2023
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8. Improvement of left ventricular ejection fraction in patients with heart failure with reduced ejection fraction: Predictors and clinical impact

Author

Perea-Armijo, Jorge, López-Aguilera, José, Prats, Rocío Sánchez, Castillo-Dominguez, Juan Carlos, Gonzalez-Manzanares, Rafael, Piserra-Lopez, Alberto, Rodriguez-Nieto, Jesús, Ruiz-Ortiz, Martín, Pericet-Rodriguez, Cristina, Delgado-Ortega, Mónica, Rodríguez-Almodovar, Ana, Esteban-Martinez, Fátima, Crespin-Crespin, Manuel, Mesa-Rubio, Dolores, Pan-Álvarez, Osorio Manuel, Anguita-Sanchez, Manuel, Sánchez-Prats, Rocío, Castillo-Domínguez, Juan Carlos, González-Manzanares, Rafael, and Anguita-Sánchez, Manuel

Published
2023
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14. The European Society of Cardiology quality indicators in atrial fibrillation in centers of excellence in Spain: the SEC-EXCELENTE FA registry

Author

Ruiz Ortiz, Martín, Arbelo, Elena, Roldán Rabadán, Inmaculada, Marín, Francisco, Pérez Cabeza, Alejandro, Marzoa Rivas, Raquel, Peinado Peinado, Rafael, Valle Alberca, Almudena, Ibáñez Criado, Alicia, Valle Muñoz, Alfonso, Osca Asensi, Joaquín, del Río Lechuga, Ana, Elola Somoza, Francisco Javier, and Anguita Sánchez, Manuel

Published
2024
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15. Los indicadores de calidad de la Sociedad Europea de Cardiología en fibrilación auricular en centros de excelencia en España: el registro SEC-EXCELENTE FA

Author

Ruiz Ortiz, Martín, Arbelo, Elena, Roldán Rabadán, Inmaculada, Marín, Francisco, Pérez Cabeza, Alejandro, Marzoa Rivas, Raquel, Peinado Peinado, Rafael, Valle Alberca, Almudena, Ibáñez Criado, Alicia, Valle Muñoz, Alfonso, Osca Asensi, Joaquín, del Río Lechuga, Ana, Elola Somoza, Francisco Javier, Anguita Sánchez, Manuel, Arbelo Laínez, Elena, Río Lechuga, Ana Del, and Pérez Cabeza, Alejandro I.

Published
2024
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16. Adverse Clinical Outcomes and Associated Predictors in Rivaroxaban-Treated Atrial Fibrillation Patients With Renal Impairment

Author

Rivera-Caravaca, José Miguel, Anguita Sanchez, Manuel, Sanmartín Fernández, Marcelo, Rafols, Carles, Barón-Esquivias, Gonzalo, Arribas Ynsaurriaga, Fernando, Freixa-Pamias, Román, Lekuona Goya, Iñaki, Vázquez Rodríguez, José Manuel, Pérez-Cabeza, Alejandro I., Cosín-Sales, Juan, Ureña Montilla, Isabel, Álvarez-Vieitez Blanco, Antonio, and Marín, Francisco

Published
2023
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17. Electrocardiographic features and need for pacemaker in cardiac amyloidosis: Analysis of 58 cases

Author

Pericet-Rodriguez, Cristina, López-Aguilera, José, Durán-Torralba, Carmen, Castillo-Dominguez, Juan Carlos, Ruiz-Ortiz, Martín, Perea-Armijo, Jorge, Delgado-Ortega, Mónica, Mesa-Rubio, Dolores, González-Manzanares, Rafael, Ruiz de Castroviejo, Joaquín, Martín-Dorado, Ernesto, Gallo-Fernández, Ignacio, López-Baizán, Josúe, Pastor-Wulf, Daniel, Rodriguez-Almodovar, Ana, Pan Álvarez-Osorio, Manuel, and Anguita-Sánchez, Manuel

Published
2022
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18. Alteraciones electrocardiográficas y necesidad de marcapasos en amiloidosis cardiaca: análisis de 58 casos

Author

Pericet-Rodriguez, Cristina, López-Aguilera, José, Durán-Torralba, Carmen, Castillo-Dominguez, Juan Carlos, Ruiz-Ortiz, Martín, Perea-Armijo, Jorge, Delgado-Ortega, Mónica, Mesa-Rubio, Dolores, González-Manzanares, Rafael, Ruiz de Castroviejo, Joaquín, Martín-Dorado, Ernesto, Gallo-Fernández, Ignacio, López-Baizán, Josúe, Pastor-Wulf, Daniel, Rodriguez-Almodovar, Ana, Pan Álvarez-Osorio, Manuel, and Anguita-Sánchez, Manuel

Published
2022
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19. Colchicine in acutely decompensated heart failure: the COLICA trial.

Author

Pascual-Figal, Domingo, Núñez, Julio, Pérez-Martínez, Maria T, González-Juanatey, José Ramón, Taibo-Urquia, Mikel, Llàcer-Iborra, Pau, Delgado, Juan, Villar, Sandra, Mirabet, Sonia, Aimo, Alberto, Riquelme-Pérez, Alejandro, Anguita-Sánchez, Manuel, Martínez-Sellés, Manuel, Noguera-Velasco, Jose A, Ibáñez, Borja, and Bayés-Genís, Antoni

Subjects
BRAIN natriuretic factor, HEART failure, VENTRICULAR ejection fraction, C-reactive protein, COLCHICINE, CONFIDENCE intervals
Abstract

Background and Aims Acute heart failure (AHF) promotes inflammatory activation, which is associated with worse outcomes. Colchicine has proven effective in other cardiovascular conditions characterized by inflammatory activation, but has never been evaluated in the setting of AHF. Methods This multicenter, randomized, double-blind, and placebo-controlled trial included patients with AHF, requiring ≥40 mg of intravenous furosemide, regardless of their left ventricular ejection fraction (LVEF) and inpatient or outpatient setting. Patients were randomized within the first 24 h of presentation to receive either colchicine or placebo, with loading dose of 2 mg, followed by 0.5 mg every 12 h for 8 weeks. Results A total of 278 patients [median age 75 years, LVEF 40%, baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) 4262 pg/mL] were randomized to colchicine (n = 141) or placebo (n = 137). The primary endpoint, the time-averaged reduction in NT-proBNP levels at 8 weeks, did not differ between the colchicine group [−62.2%, 95% confidence interval (CI) −68.9% to −54.2%] and the placebo group (−62.1%, 95% CI −68.6% to −54.3%) (ratio of change 1.0). The reduction in inflammatory markers was significantly greater with colchicine: ratio of change 0.60 (P <.001) for C-reactive protein and 0.72 (P =.019) for interleukin-6. No differences were found in new worsening heart failure episodes (14.9% with colchicine vs. 16.8% with placebo, P =.698); however, the need for intravenous furosemide during follow-up was lower with colchicine (P =.043). Diarrhea was slightly more common with colchicine, but it did not result in differences in medication withdrawal (8.5% vs. 8.8%). Conclusions Colchicine was safe and effective in reducing inflammation in patients with AHF; however, colchicine and placebo exhibited comparable effects on reducing NT-proBNP and preventing new worsening heart failure events. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Caracterización y pronóstico del paciente con amiloidosis cardiaca: experiencia de un centro

Author

Pericet-Rodríguez, Cristina, López-Aguilera, José, Durán-Torralba, Carmen, Castillo-Domínguez, Juan Carlos, Ruiz-Ortiz, Martín, Perea-Armijo, Jorge, Delgado-Ortega, Mónica, Mesa-Rubio, Dolores, González-Manzanares, Rafael, Ruiz de Castroviejo, Joaquín, Esteban-Martínez, Fátima, López-Granados, Amador, Maza-Muret, Roberto, Espejo-Pérez, Simona, Ortega-Salas, Rosa, Álvarez-Ossorio, Manuel Pan, and Anguita-Sánchez, Manuel

Published
2022
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21. Outcomes of patients with heart failure followed in units accredited by the SEC-Excelente-IC quality program according to the type of unit

Author

Anguita Gámez, María, primary, Bonilla Palomas, Juan L., additional, Recio Mayoral, Alejandro, additional, González Manzanares, Rafael, additional, Muñiz García, Javier, additional, Romero Rodríguez, Nieves, additional, Elola Somoza, Francisco J., additional, Cequier Fillat, Ángel, additional, Rodríguez Padial, Luis, additional, and Anguita Sánchez, Manuel, additional

Published
2024
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22. Stratification and management of cardiovascular risk in cancer patients. A consensus document of the SEC, FEC, SEOM, SEOR, SEHH, SEMG, AEEMT, AEEC, and AECC

Author

Martín García, Ana, Mitroi, Cristina, Mazón Ramos, Pilar, García Sanz, Ramón, Virizuela, Juan Antonio, Arenas, Meritxell, Egocheaga Cabello, Isabel, Albert, Dimpna, Anguita Sánchez, Manuel, Arrarte Esteban, Vicente Ignacio, Ayala de la Peña, Francisco, Bonanand Lozano, Clara, Castro, Almudena, Castro Fernández, Antonio, Córdoba, Raúl, Cosín-Sales, Juan, Chaparro-Muñoz, Marinela, Dalmau, Regina, Drak Hernández, Yasmin, Deiros Bronte, Lucía, Díez-Villanueva, Pablo, Escobar Cervantes, Carlos, Fernández Redondo, Concepción, García Rodríguez, Estíbaliz, Lozano, Teresa, Marco Vera, Pascual, Martínez Monzonis, Amparo, Mesa, Dolores, Oristrell, Gerard, Palma Gámiz, José Luis, Pedreira, Milagros, Reinoso-Barbero, Luis, Rodríguez, Isabel, Serrano Antolín, José María, Toral, Belén, Torres Royo, Laura, Velasco del Castillo, Sonia, Vicente-Herrero, Teófila, Zatarain-Nicolás, Eduardo, Tamargo, Juan, and López Fernández, Teresa

Published
2021
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23. Estratificación, monitorización y control del riesgo cardiovascular en pacientes con cáncer. Documento de consenso de SEC, FEC, SEOM, SEOR, SEHH, SEMG, AEEMT, AEEC y AECC

Author

Martín García, Ana, Mitroi, Cristina, Mazón Ramos, Pilar, García Sanz, Ramón, Virizuela, Juan Antonio, Arenas, Meritxell, Egocheaga Cabello, Isabel, Albert, Dimpna, Anguita Sánchez, Manuel, Arrarte Esteban, Vicente Ignacio, Ayala de la Peña, Francisco, Bonanand Lozano, Clara, Castro, Almudena, Castro Fernández, Antonio, Córdoba, Raúl, Cosín-Sales, Juan, Chaparro-Muñoz, Marinela, Dalmau, Regina, Drak Hernández, Yasmin, Deiros Bronte, Lucía, Díez-Villanueva, Pablo, Escobar Cervantes, Carlos, Fernández Redondo, Concepción, García Rodríguez, Estíbaliz, Lozano, Teresa, Marco Vera, Pascual, Martínez Monzonis, Amparo, Mesa, Dolores, Oristrell, Gerard, Palma Gámiz, José Luis, Pedreira, Milagros, Reinoso-Barbero, Luis, Rodríguez, Isabel, Serrano Antolín, José María, Toral, Belén, Torres Royo, Laura, Velasco del Castillo, Sonia, Vicente-Herrero, Teófila, Zatarain-Nicolás, Eduardo, Tamargo, Juan, and López Fernández, Teresa

Published
2021
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24. Safety and Effectiveness of Oral Anticoagulants in Atrial Fibrillation: Real-World Insights Using Natural Language Processing and Machine Learning.

Author

Cosín-Sales, Juan, Anguita Sánchez, Manuel, Suárez, Carmen, Arias-Cabrales, Carlos, Martínez-Sanchez, Luisa, Arumi, Daniel, and Fernández de Cabo, Susana

Subjects
*NATURAL language processing, *MITRAL stenosis, *HEART valve diseases, *ANTICOAGULANTS, *ARTIFICIAL intelligence
Abstract

Background/Objectives: We assessed the effectiveness and safety of vitamin K antagonists (VKAs) versus direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) using artificial intelligence techniques. Methods: This is a retrospective study in 15 Spanish hospitals (2014–2020), including adult AF patients with no history of anticoagulation, thrombosis events, rheumatic mitral valvular heart disease, mitral valve stenosis, or pregnancy. We employed EHRead® technology based on natural language processing (NLP) and machine learning (ML), along with SNOMED-CT terminology, to extract clinical data from electronic health records (EHRs). Using propensity score matching (PSM), the effectiveness, safety, and hospital mortality of VKAs versus DOACs were analyzed through Kaplan–Meier curves and Cox regression. Results: Out of 138,773,332 EHRs from 4.6 million individuals evaluated, 44,292 patients were included, 79.6% on VKAs and 20.4% on DOACs. Most patients were elderly [VKA 78 (70, 84) and DOAC 75 (66, 83) years], with numerous comorbidities (75.5% and 70.2% hypertension, 47.2% and 39.9% diabetes, and 40.3% and 34.8% heart failure, respectively). Additionally, 60.4% of VKA and 48.7% of DOAC users had a CHA2DS2-VASc Score ≥4. After PSM, 8929 patients per subgroup were selected. DOAC users showed a lower risk of thrombotic events [HR 0.81 (95% CI 0.70–0.94)], minor bleeding [HR 0.89 (95% CI 0.83–0.96)], and mortality [HR 0.80 (95% CI 0.69–0.92)]. Conclusions: Applying NLP and ML, we generated valuable real-world evidence on anticoagulated AF patients in Spain. Even in complex populations, DOACs have demonstrated a better safety and effectiveness profile than VKAs. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Colchicine in acute heart failure: Rationale and design of a randomized double‐blind placebo‐controlled trial (COLICA).

Author

Pascual‐Figal, Domingo, Núñez Villota, Julio, Pérez‐Martínez, Maria Teresa, González‐Juanatey, José Ramón, Taibo‐Urquía, Mikel, Llàcer Iborra, Pau, González‐Martín, Javier, Villar, Sandra, Soler, Meritxel, Mirabet, Sonia, Aimo, Alberto, Riquelme‐Pérez, Alejandro, Anguita Sánchez, Manuel, Martínez‐Sellés, Manuel, Sánchez, Pedro L., Ibáñez, Borja, Bayés‐Genís, Antoni, Martínez, Andrés Ramón, Pérez, Alejandro Riquelme, and Bravo, Iris Paula Garrido

Subjects
HEART failure, TREATMENT effectiveness, VENTRICULAR ejection fraction, GLOMERULAR filtration rate, COLCHICINE, PEPTIDES
Abstract

Aims: Heart failure (HF) elicits a pro‐inflammatory state, which is associated with impaired clinical outcomes, but no anti‐inflammatory therapies have demonstrated a clinical benefit yet. Inflammatory pathways related with the interleukin‐1 axis are overactivated during episodes of acute HF. Colchicine, an anti‐inflammatory drug with proven benefits in acute pericarditis and ischaemic heart disease, may target this inflammatory response. This study aims to assess the efficacy of colchicine in acute HF patients. Methods: COLICA is a multicentre, randomized, double‐blind, placebo‐controlled trial enrolling 278 patients across 12 sites. Patients presenting with acute HF, clinical evidence of congestion requiring ≥40 mg of intravenous furosemide and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) >900 pg/ml, are eligible for participation. Patients are enrolled irrespective of left ventricular ejection fraction, HF type (new‐onset or not) and setting (hospital or outpatient clinic). Patients are randomized 1:1 within the first 24 h of presentation to either placebo or colchicine, with an initial loading dose of 2 mg followed by 0.5 mg every 12 h for 8 weeks (reduced dose if <70 kg, >75 years old, or glomerular filtration rate <50 ml/min/1.73 m2). The primary efficacy endpoint is the time‐averaged proportional change in NT‐proBNP concentrations from baseline to week 8. Key secondary and exploratory outcomes include symptoms, diuretic use, worsening HF episodes, related biomarkers of cardiac stress and inflammation, total and cardiovascular readmissions, mortality and safety events. Conclusion: COLICA will be the first randomized trial testing the efficacy and safety of colchicine for acute HF. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Influence of sex on long-term prognosis in patients with atrial fibrillation treated with oral anticoagulants. Results from the prospective, nationwide FANTASIIA study

Author

Roldán Rabadán, Inmaculada, Esteve-Pastor, María Asunción, Anguita Sánchez, Manuel, Muñiz, Javier, Ruiz Ortiz, Martín, Marín, Francisco, Roldán, Vanessa, Quesada, María Angustias, Camacho Siles, José, Cequier Fillat, Angel, Bertomeu Martinez, Vicente, Martínez Sellés, Manuel, and Badimón, Lina

Published
2020
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37. Atrial Fibrillation in Active Cancer Patients: Expert Position Paper and Recommendations

Author

Marín, Francisco, López-Sendón, José Luis, Zamorano, José Luis, López-Fernández, Teresa, Martín-García, Ana, Roldán Rabadán, Inmaculada, Mitroi, Cristina, Mazón Ramos, Pilar, Díez-Villanueva, Pablo, Escobar Cervantes, Carlos, Alonso Martín, Concepción, Alonso Salinas, Gonzalo Luis, Arenas, Meritxell, Arrarte Esteban, Vicente Ignacio, Ayala de La Peña, Francisco, Castro Fernández, Antonio, García Pardo, Héctor, García-Sanz, Ramón, González Porras, José Ramón, López de Sá, Esteban, Lozano, Teresa, Marco Vera, Pascual, Martínez Marín, Virginia, Mesa Rubio, Dolores, Montero, Ángel, Oristrell, Gerard, Pérez de Prado, Armando, Velasco del Castillo, Sonia, Virizuela Echaburu, Juan Antonio, Zatarain-Nicolás, Eduardo, Anguita Sánchez, Manuel, and Tamargo Menéndez, Juan

Published
2019
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38. Abordaje de la fibrilación auricular en pacientes con cáncer activo. Documento de consenso de expertos y recomendaciones

Author

Marín, Francisco, López-Sendón, José Luis, Zamorano, José Luis, López-Fernández, Teresa, Martín-García, Ana, Roldán Rabadán, Inmaculada, Mitroi, Cristina, Mazón Ramos, Pilar, Díez-Villanueva, Pablo, Escobar Cervantes, Carlos, Alonso Martín, Concepción, Alonso Salinas, Gonzalo Luis, Arenas, Meritxell, Arrarte Esteban, Vicente Ignacio, Ayala de La Peña, Francisco, Castro Fernández, Antonio, García Pardo, Héctor, García-Sanz, Ramón, González Porras, José Ramón, López de Sá, Esteban, Lozano, Teresa, Marco Vera, Pascual, Martínez Marín, Virginia, Mesa Rubio, Dolores, Montero, Ángel, Oristrell, Gerard, Pérez de Prado, Armando, Velasco del Castillo, Sonia, Virizuela Echaburu, Juan Antonio, Zatarain-Nicolás, Eduardo, Anguita Sánchez, Manuel, and Tamargo Menéndez, Juan

Published
2019
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39. Cardiologists and the Cardiology of the Future. Vision and proposals of the Spanish Society of Cardiology for the Cardiology of the 21st Century

Author

Anguita Sánchez, Manuel, Alonso Martín, Joaquín J., Cequier Fillat, Ángel, Gómez Doblas, Juan José, Pulpón Rivera, Luis, Lekuona Goya, Iñaki, Rodríguez Rodrigo, Francisco, Íñiguez Romo, Andrés, Macaya Miguel, Carlos, Evangelista Masip, Arturo, Silva Melchor, Lorenzo, Bueno, Héctor, Díaz Molina, Beatriz, Ferreira-González, Ignacio, and Elola Somoza, Francisco Javier

Published
2019
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40. El Cardiólogo y la Cardiología del Futuro: visión y propuestas de la Sociedad Española de Cardiología para la cardiología del siglo XXI

Author

Anguita Sánchez, Manuel, Alonso Martín, Joaquín J., Cequier Fillat, Ángel, Gómez Doblas, Juan José, Pulpón Rivera, Luis, Lekuona Goya, Iñaki, Rodríguez Rodrigo, Francisco, Íñiguez Romo, Andrés, Macaya Miguel, Carlos, Evangelista Masip, Arturo, Silva Melchor, Lorenzo, Bueno, Héctor, Díaz Molina, Beatriz, Ferreira-González, Ignacio, and Elola Somoza, Francisco Javier

Published
2019
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41. Gender differences in clinical features and outcomes of patients over 75 years presenting with acute heart failure. Results of a nationwide study (2016–2019)

Author

Anguita-Gámez, María, primary, Esteban-Fernández, Alberto, additional, Bonilla-Palomas, Juan L., additional, Bernal, José L., additional, Del Prado, Náyade, additional, Fernández-Pérez, Cristina, additional, Elola-Somoza, Francisco J., additional, and Anguita-Sánchez, Manuel, additional

Published
2024
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44. The Worsening of Heart Failure with Reduced Ejection Fraction: The Impact of the Number of Hospital Admissions in a Cohort of Patients

Author

Perea-Armijo, Jorge, primary, López-Aguilera, José, additional, González-Manzanares, Rafael, additional, Pericet-Rodriguez, Cristina, additional, Castillo-Domínguez, Juan Carlos, additional, Heredia-Campos, Gloria, additional, Roldán-Guerra, Álvaro, additional, Urbano-Sánchez, Cristina, additional, Barreiro-Mesa, Lucas, additional, Aguayo-Caño, Nerea, additional, Delgado-Ortega, Mónica, additional, Crespín-Crespín, Manuel, additional, Ruiz-Ortiz, Martín, additional, Mesa-Rubio, Dolores, additional, Osorio, Manuel Pan-Álvarez, additional, and Anguita-Sánchez, Manuel, additional

Published
2023
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