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235 results on '"Angstwurm, Klemens"'

4. Weaning and extubation failure in myasthenic crisis: a multicenter analysis

Author

Neumann, Bernhard, Angstwurm, Klemens, Dohmen, Christian, Mergenthaler, Philipp, Kohler, Siegfried, Schönenberger, Silvia, Lee, De-Hyung, Gerner, Stefan T., Huttner, Hagen B., Thieme, Andrea, Steinbrecher, Andreas, Dunkel, Juliane, Roth, Christian, Schneider, Hauke, Reichmann, Heinz, Fuhrer, Hannah, Kleiter, Ingo, Schneider-Gold, Christiane, Alberty, Anke, Zinke, Jan, Schroeter, Michael, Linker, Ralf, Meisel, Andreas, Bösel, Julian, and Stetefeld, Henning R.

Published
2024
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5. Seronegative myasthenic crisis: a multicenter analysis

Author

Mergenthaler, Philipp, Stetefeld, Henning R., Dohmen, Christian, Kohler, Siegfried, Schönenberger, Silvia, Bösel, Julian, Gerner, Stefan T., Huttner, Hagen B., Schneider, Hauke, Reichmann, Heinz, Fuhrer, Hannah, Berger, Benjamin, Zinke, Jan, Alberty, Anke, Kleiter, Ingo, Schneider-Gold, Christiane, Roth, Christian, Dunkel, Juliane, Steinbrecher, Andreas, Thieme, Andrea, Lee, De-Hyung, Linker, Ralf A., Angstwurm, Klemens, Meisel, Andreas, and Neumann, Bernhard

Published
2022
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6. Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force

Author

Cuvelier, Geoffrey D.E., Schoettler, Michelle, Buxbaum, Nataliya P., Pinal-Fernandez, Iago, Schmalzing, Marc, Distler, Jörg H.W., Penack, Olaf, Santomasso, Bianca D., Zeiser, Robert, Angstwurm, Klemens, MacDonald, Kelli P.A., Kimberly, W. Taylor, Taylor, Naomi, Bilic, Ervina, Banas, Bernhard, Buettner-Herold, Maike, Sinha, Namita, Greinix, Hildegard T., Pidala, Joseph, Schultz, Kirk R., Williams, Kirsten M., Inamoto, Yoshihiro, Cutler, Corey, Griffith, Linda M., Lee, Stephanie J., Sarantopoulos, Stefanie, Pavletic, Steven Z., and Wolff, Daniel

Published
2022
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7. Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

Author

Jarius, Sven, Pache, Florence, Körtvelyessy, Peter, Jelčić, Ilijas, Stettner, Mark, Franciotta, Diego, Keller, Emanuela, Neumann, Bernhard, Ringelstein, Marius, Senel, Makbule, Regeniter, Axel, Kalantzis, Rea, Willms, Jan F., Berthele, Achim, Busch, Markus, Capobianco, Marco, Eisele, Amanda, Reichen, Ina, Dersch, Rick, Rauer, Sebastian, Sandner, Katharina, Ayzenberg, Ilya, Gross, Catharina C., Hegen, Harald, Khalil, Michael, Kleiter, Ingo, Lenhard, Thorsten, Haas, Jürgen, Aktas, Orhan, Angstwurm, Klemens, Kleinschnitz, Christoph, Lewerenz, Jan, Tumani, Hayrettin, Paul, Friedemann, Stangel, Martin, Ruprecht, Klemens, and Wildemann, Brigitte

Published
2022
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8. Long-term elevation of complement factors in cerebrospinal fluid of patients with Borna disease virus 1 (BoDV-1) encephalitis

Author

Bauswein, Markus, primary, Zoubaa, Saida, additional, Toelge, Martina, additional, Eidenschink, Lisa, additional, Riemenschneider, Markus J, additional, Neumann, Bernhard, additional, Lee, De-Hyung, additional, Eid, Ehab, additional, Tappe, Dennis, additional, Niller, Hans Helmut, additional, Gessner, André, additional, Schmidt, Barbara, additional, Bülow, Sigrid, additional, and Angstwurm, Klemens, additional

Published
2024
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9. Seizure Semiology in Antibody-Associated Autoimmune Encephalitis

Author

Kaaden, Tillman, Madlener, Marie, Angstwurm, Klemens, Bien, Christian G., Bogarin, Yuri, Doppler, Kathrin, Finke, Alexander, Gerner, Stefan T., Reimann, Gernot, Häusler, Martin, Handreka, Robert, Hellwig, Kerstin, Kaufmann, Max, Kellinghaus, Christoph, Koertvelyessy, Peter, Kraft, Andrea, Lewerenz, Jan, Menge, Til, Paliantonis, Asterios, von Podewils, Felix, Prüss, Harald, Rauer, Sebastian, Ringelstein, Marius, Rostásy, Kevin, Schirotzek, Ingo, Schwabe, Julia, Sokolowski, Piotr, Suesse, Marie, Sühs, Kurt-Wolfram, Surges, Rainer, Tauber, Simone C., Thaler, Franziska, Bergh, Florian Then, Urbanek, Christian, Wandinger, Klaus-P., Wildemann, Brigitte, Mues, Sigrid, Zettl, Uwe, Leypoldt, Frank, Melzer, Nico, Geis, Christian, Malter, Michael, and Kunze, Albrecht

Published
2022
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10. Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018-2020

Author

Eisermann, Philip, Rubbenstroth, Dennis, Cadar, Daniel, Thome-Bolduan, Corinna, Eggert, Petra, Schlaphof, Alexander, Leypoldt, Frank, Stangel, Martin, Fortwangler, Thorsten, Hoffmann, Florian, Osterman, Andreas, Zange, Sabine, Niller, Hans-Helmut, Angstwurm, Klemens, Portner, Kirsten, Frank, Christina, Wilking, Hendrik, Beer, Martin, Schmidt-Chanasit, Jonas, and Tappe, Dennis

Subjects
Encephalitis -- Case studies -- Causes of, RNA virus infections -- Case studies -- Diagnosis, Health
Abstract

Human bornavirus encephalitis is a severe and often fatal disease caused by 2 related zoonotic members of the family Bornaviridae, variegated squirrel bornavirus 1 (VSBV-1, species Mammalian 2 orthobornavirus) and [...]

Published
2021
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12. Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999–2019: an epidemiological investigation

Author

Niller, Hans Helmut, Angstwurm, Klemens, Rubbenstroth, Dennis, Schlottau, Kore, Ebinger, Arnt, Giese, Sebastian, Wunderlich, Silke, Banas, Bernhard, Forth, Leonie F, Hoffmann, Donata, Höper, Dirk, Schwemmle, Martin, Tappe, Dennis, Schmidt-Chanasit, Jonas, Nobach, Daniel, Herden, Christiane, Brochhausen, Christoph, Velez-Char, Natalia, Mamilos, Andreas, Utpatel, Kirsten, Evert, Matthias, Zoubaa, Saida, Riemenschneider, Markus J, Ruf, Viktoria, Herms, Jochen, Rieder, Georg, Errath, Mario, Matiasek, Kaspar, Schlegel, Jürgen, Liesche-Starnecker, Friederike, Neumann, Bernhard, Fuchs, Kornelius, Linker, Ralf A, Salzberger, Bernd, Freilinger, Tobias, Gartner, Lisa, Wenzel, Jürgen J, Reischl, Udo, Jilg, Wolfgang, Gessner, André, Jantsch, Jonathan, Beer, Martin, and Schmidt, Barbara

Published
2020
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14. Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis

Author

Tietz, Anja K., Angstwurm, Klemens, Baumgartner, Tobias, Doppler, Kathrin, Eisenhut, Katharina, Elisak, Martin, Franke, Andre, Golombeck, Kristin S., Handreka, Robert, Kaufmann, Max, Kraemer, Markus, Kraft, Andrea, Lewerenz, Jan, Lieb, Wolfgang, Madlener, Marie, Melzer, Nico, Mojzisova, Hana, Möller, Peter, Pfefferkorn, Thomas, Prüss, Harald, Rostásy, Kevin, Schnegelsberg, Margret, Schröder, Ina, Siebenbrodt, Kai, Sühs, Kurt-Wolfram, Wickel, Jonathan, Wandinger, Klaus-Peter, Leypoldt, Frank, and Kuhlenbäumer, Gregor

Published
2021
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15. Time to Disability Milestones and Annualized Relapse Rates in NMOSD and MOGAD.

Author

Duchow, Ankelien, Bellmann‐Strobl, Judith, Friede, Tim, Aktas, Orhan, Angstwurm, Klemens, Ayzenberg, Ilya, Berthele, Achim, Dawin, Eva, Engels, Daniel, Fischer, Katinka, Flaskamp, Martina, Giglhuber, Katrin, Grothe, Matthias, Havla, Joachim, Hümmert, Martin W., Jarius, Sven, Kaste, Matthias, Kern, Peter, Kleiter, Ingo, and Klotz, Luisa

Subjects
NEUROMYELITIS optica
Abstract

Objective: To investigate accumulation of disability in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein‐antibody‐associated disease (MOGAD) in a changing treatment landscape. We aimed to identify risk factors for the development of disability milestones in relation to disease duration, number of attacks, and age. Methods: We analyzed data from individuals with NMOSD and MOGAD from the German Neuromyelitis Optica Study Group registry. Applying survival analyses, we estimated risk factors and computed time to disability milestones as defined by the Expanded Disability Status Score (EDSS). Results: We included 483 patients: 298 AQP4‐IgG+ NMOSD, 52 AQP4‐IgG−/MOG‐IgG− NMOSD patients, and 133 patients with MOGAD. Despite comparable annualized attack rates, disability milestones occurred earlier and after less attacks in NMOSD patients than MOGAD patients (median time to EDSS 3: AQP4‐IgG+ NMOSD 7.7 (95% CI 6.6–9.6) years, AQP4‐IgG−/MOG‐IgG− NMOSD 8.7) years, MOGAD 14.1 (95% CI 10.4–27.6) years; EDSS 4: 11.9 (95% CI 9.7–14.7), 11.6 (95% lower CI 7.6) and 20.4 (95% lower CI 14.1) years; EDSS 6: 20.1 (95% CI 16.5–32.1), 20.7 (95% lower CI 11.6), and 37.3 (95% lower CI 29.4) years; and EDSS 7: 34.2 (95% lower CI 31.1) for AQP4‐IgG+ NMOSD). Higher age at onset increased the risk for all disability milestones, while risk of disability decreased over time. Interpretation: AQP4‐IgG+ NMOSD, AQP4‐IgG−/MOG‐IgG− NMOSD, and MOGAD patients show distinctive relapse‐associated disability progression, with MOGAD having a less severe disease course. Investigator‐initiated research has led to increasing awareness and improved treatment strategies appearing to ameliorate disease outcomes for NMOSD and MOGAD. ANN NEUROL 2024;95:720–732 [ABSTRACT FROM AUTHOR]

Published
2024
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16. Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting

Author

Correale, Jorge, Caride, Alejandro, Deri, Norma H., Ballario, Carlos, Broadley, Simon, Kneebone, Chris, Barnett, Michael, Pollard, John, Hodgkinson, Suzanne, Kermode, Allan, Macdonell, Richard, King, John, Butzkueven, Helmut, Lechner-Scott, Jeannette, Saines, Noel, Slee, Mark, Plummer, Chris, Willekens, Barbara, Vanopdenbosch, Ludo, Belachew, Shibeshih, Phan-Ba, Rémy, Delvaux, Valérie, Bissay, Veronique, Debruyne, Jan, Decoo, Danny, Crols, Roeland, Symons, Anoek, Nagels, Guy, Van Pesch, Vincent, Sindic, Christian, Dubois, Benedicte, Medaer, Robert, D'Hooghe, Marie, Guillaume, Daniel, De Smet, Eric, Seeldrayers, Pierrette, Lysandropoulos, Andreas, Vokaer, Mathieu, Geens, Karine, Willems, Christina, Denayer, Pierre, Bureau, Michel, Retif, Cecile, Dupuis, Michel, Bouquiaux, Olivier, Vanderdonckt, Patrick, van Landegem, William, Caekebeke, Jo, Van Ingelghem, Erwin, Peeters, Katelijne, Gerard, Pascale, de Noordhout, Alain Maertens, Desfontaines, Philippe, Urbain, Etienne, Declercq, Inge, Van Wijmeersch, Bart, Vanroose, Erwin, Wibail, Alain, Barthomolé, Emmanuel, Ursell, Melanie, Sweet, Margaret Elizabeth, Howse, David, Jichici, Draga, Shawush, Melad, Namaka, Mike, Traboulsee, Anthony, Hashimoto, Stan, Lo, Raymond, Marchetti, Paul, Lapierre, Yves, Jacques, Francois, MacLean, Gregg, Bhan, Virender, Duquette, Pierre, Stewart, Bradley, Paulseth, John, Kremenchutzky, Marcelo, Vorobeychik, Galina, O'Connor, Paul, Grand'Maison, François, Havrdova, Eva, Meluzinová, Eva, Valis, Martin, Talab, Radomír, Stourac, Pavel, Zapletalová, Olga, Dufek, Michal, Sládková, Vladimíra, Novotna, Alena, Vancurová, Romana, Lhotaková, Libuse, Fiedler, Jiri, Vachova, Marta, Dolezil, David, Stetkarova, Ivana, Rehankova, Adela, Psenica, Petr, Ulehlova, Veronika, Feketova, Sona, Skoda, Ondrej, Färkkilä, Markus, Taneli, Sarasoja, Koivisto, Keijo, Seppä, Juha Matti, Airas, Laura, Elovaara, Irina, Hartikainen, Päivi, Pirttila, Tuula, Louchart, Pierre, Ille, Olivier, Thenint, Jean philippe, Godet, Etienne, Vioud, Marcel Maillet, Colamarino, Renato, Gugenheim, Michel, Grimaud, Jerome, Kopf, Audrey, Billy, Christophe, Huttin, Bernard, Borsotti, Jean paul, Devos, Philippe, Kendjuo, Jean bertin N, Verier, Albert, Chapuis, Stephane, Daluzeau, Nathalie, Angibaud, Gilles, Uriot, Marie-Sylvie Artaud, Ziegler, François, Sellal, François, Moulignier, Antoine, Lavenu, Isabelle, Ismail, Samir, Devy, Richard, Suceveanu, Manuel, Wagner, Marc, Marcel, Sebastien, Derouiche, Faycal, Mostoufizadehghalamfarsa, Sohrab, Delalande, Sophie, Ruggieri, Irene, Van Nieuwenhuyse, Catherine Bossu, Nifle, Chantal, Ondze, Basile, Vasilescu, Carmen Gurau, Vongsouthi, Cyrille, Coustans, Marc, Anne, Olivier, Amevigbe, Josephine, Servan, Jerome, Merienne, Marc, Eck, Philippe, Berroir, Stephane, Busson, Philippe, Barroso, Bruno, Larrieu, Jean-Marc, Giendaj, Catherine Louvet, Malkoun, Imad, Hautecoeur, Patrick, Kwiatkowski, Arnaud, Pouliquen, Andre, Garrigues, Guillaume, Delerue, Olivier, Giraud, Pierric, Gere, Julien, Vaunaize, Jean, Dereeper, Olivier, Seiller, Nicolas, Alsassa, Roger, Vlaicu, Mihaela, Neuville, Veronique, Faucheux, Jean Marc, Bernady, Patricia, Fanjaud, Guy, Viallet, François, Schroeter, Michael, Schlemilch-Paschen, Sylke, Lange, Thomas, Bohr, Kin-Arno, Jendroska, Klaus, Rehkopf, Elisabeth, Bergmann, Arnfin, Kleinschnitz, Christoph, Postert, Thomas, Scholz, Peter, Mauz, Uwe, Stratmann, Hubert, Siefjediers, Veneta, Prantl, Martin, Gehring, Klaus, Zellner, Ruth, Junge, Kathrin, Zellner, Anton, Bacay, Valerina, Schlegel, Eugen, Polzer, Udo, Strauss, Erik, Link, Andreas, Stenzel, Christoph, Freidel, Matthias, Drews, Joachim, Neudert, Christian, Schmitz, Frank, Jaeger, Joachim, Masri, Said, Heuberger, Wolfgang, Trausch, Beate, Ruhnke, Oliver, Scarel, Serena, Bach, Kathlen, Ernst, Michael, Landefeld, Harald, Richter, Nils, Schmidt, Stephan, Krause, Michaela, Dressel, Alezander, Ruth, Roland, Anvari, Kerstin, Gossling, Jens, Schenk, Christoph, Tiedge, Oliver, Bode, Lutz, Eder, Hans-Thomas, Pfeffer, Oliver, Krug, Reinhard, Lassek, Christoph, Fleischer, Eberhard, Meuth, Sven, Klotz, Luisa Hildegard, Peglau, Ines, Kukowski, Borries, Herting, Birgit, Guthke, Kersten, Schierenbeck, Jurgen, Brockmeier, Bernd, Albrecht, Holger, Wuttke, Matthias, Augspach-Hofmann, Regine, Gunther, Stefan, Redbrake, Martin, Franke, Christian, Buchner, Klaus, Gratz, Thomas, Horn, Rolf, Doemges, Frank, Schreiber, Martin, Brosch, Thomas, Horn, Markus, Kittlitz, Matthias, Vulturius, Gabriele, Hinse, Paul, Malessa, Rolf, Wiehler, Stephan, Katsarava, Zaza, Kastrup, Oliver, Kausch, Ulrich, Gullekes, Martin, Fickinger, Markus, Wenzel, Wilhelm, Botefur, Ingolf C., Reifschneider, Gerd, Rauer, Sebastian, Lang, Michael, Harms, Lutz, Eckhardt, Ulrich, Cursiefen, Simone, Linker, Ralf, Angstwurm, Klemens, Haas, Judith, Schuetze, Ivo, Rohm, Eva, Stienker-Fisse, H., Sailer, Michael, Bohringer, Johannes, Maurer, Mathias, Bause, Eberhard, Wersching, Ronald, Dachsel, Reinhardt, Domke, Sylke, Hoffman, Frank, Tackenberg, Bjorn, Roch, Kerstin, Ziebold, Uwe, Kallmann, Boris, Buehler, Bernhard, Faiss, Judith, Faiss, Juergen, Schimrigk, Sebastian, Menges, Christian, Knop, Karl Christian, Koehler, Wolfgang, Siever, Arno, Bufler, Johannes, Gramsl, Georg, Kuhnler, Benedicta, Maschke, Matthias, Stogbauer, Florian, Staude, Lisa, Bethke, Florian, Bitsch, Andreas, Harmjanz, Arndt D., Windsheimer, Jorg, Kieseier, Bernd C., Berkenfeld, Ralf, Tumani, Hayrettin, Kirsch, Michael, Wildemann, Brigitte, Daniels, Regina, Gottwald, Klaus, Elias, Wolfgang-Gerhard, Hoffmann, Olaf, Schwab, Matthias, Pilz, Christopher, Klostermann, Fabian, Hellwig, Kerstin, Berthele, Achim, Bayas, Antonios, Molitor, Daniel, Grothe, Christoph, Wagner, Bert, Karageorgiou, Klimentini, Mitsikostas, Dimosthenis, Kodounis, Antonios, Plaitakis, Andreas, Papadimitriou, Alexandros, Grigoriadis, Nikolaos, Vlaikidis, Nikolaos, Koutlas, Evaggelos, Kyritsis, Athanassios, Papathanassopoulos, Panagiotis, Makris, Nikolaos, Tavernarakis, Antonios, Scarpini, Elio, Montanari, Enrico, Marrosu, Maria Giovanna, Trojano, Maria, Amato, Maria Pia, Rottoli, Mariarosa, Lugaresi, Alessandra, Florio, Ciro, Gasperini, Claudio, Grimaldi, Luigi, Millefiorini, Enrico, Koudriavtseva, Tatiana, Perla, Franco, Mantegazza, Renato, Bertolotto, Antonio, Ghezzi, Angelo, Aguilar, Sandra Quinones, Eisenberg, Eli Skromne, Lopez, Leondardo Llamas, Estudillo, Rocio Marquez, Schrijver, H.M., Wittebol, M.C., Baart, J.C., van Golde, A.E.L., Hengstman, G.J.D., Pop, P.H.M., Bos (Geldrop), M., Medaer, R., Schyns-Soeterboek, Angelique, van der Zwart, A., van Diepen, A.J.H., Verheul, G.A.M., Verhagen, W.I.M., Bos (Helmond), M., Witjes, R.J.G.M., Sinnige, L.G.F., van Munster, E.Th.L., Sanders, E.A.C.M., van Dijl, Ron, Hupperts, R.M.M., Frequin, S.T.F.M., Visser, L.H., Henselmans, J.M.L., Moll, J.W.B., Midgard, Rune, Myhr, Kjell Morten, Edland, Astrid, Telstad, Wenche, Hognestad, Tone, Lund, Christian, Hovdal, Harald, Kamaljit, Kaur, Schepel, Jan, Hogenesch, Roelfien Ida, Schüler, Stephan, Odeh, Francis, Alstadhaug, Karl B., Korsgaard, Olav, Farbu, Elisabeth, Ingvaldsen, Teis Barclay, Soares (SCO), Diana, Rente, José, Guerra, José Manuel Costa, Morganho, Armando, Leitão, António, de Sá, João, Sá, Maria José, Marques, Pinto, Veloso, Mário, Baptista, Miguel Viana, Szilasiová, Jarmila, Copikova-Cudrakova, Daniela, Prochazkova, Lubica, Klimová, Eleonóra, Donath, Vladimir, Brozman, Miroslav, Ramo, Cristina, Ruiz, Domingo Pérez, Hernández, Carmen Calles, Sola, María Eugenia Marzo, Moro, Roberto Suarez, Vidal, Jose Antonio, Rodríguez, Ana Belén Caminero, Ozaeta, Gisela Martin, Nadal, Jordi Batlle, Esquide, Amaya Alvarez de Arcaya, Urtaza, Javier Olascoaga, Martínez-Yélamos, Sergio, Arbizu, Txomin, Torrenta, Lluis Ramio i, Boggild, Mike, Wilson, Martin, Al-Araji, Adnan, Nicholas, Richard, Harrower, Timothy, Redmond, Ian, Wolf, Tilo, Osei-Bonsu, Michael, Mazibrada, Gordon, Rog, David, Cottrell, David, Constantinescu, Cris, Gray, Orla, Belhag, Mohamed, Shehu, Abdullah, Rashid, Waqar, Duddy, Martin, Kappos, Ludwig, Wiendl, Heinz, Spelman, Tim, Pellegrini, Fabio, Chen, Yi, Dong, Qunming, and Koendgen, Harold

Published
2018
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17. The neuropathology of fatal encephalomyelitis in human Borna virus infection

Author

Liesche, Friederike, Ruf, Viktoria, Zoubaa, Saida, Kaletka, Gwendolyn, Rosati, Marco, Rubbenstroth, Dennis, Herden, Christiane, Goehring, Lutz, Wunderlich, Silke, Wachter, Miguel Frederic, Rieder, Georg, Lichtmannegger, Ines, Permanetter, Willibald, Heckmann, Josef G., Angstwurm, Klemens, Neumann, Bernhard, Märkl, Bruno, Haschka, Stefan, Niller, Hans-Helmut, Schmidt, Barbara, Jantsch, Jonathan, Brochhausen, Christoph, Schlottau, Kore, Ebinger, Arnt, Hemmer, Bernhard, Riemenschneider, Markus J., Herms, Jochen, Beer, Martin, Matiasek, Kaspar, and Schlegel, Jürgen

Published
2019
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19. Myasthenic crisis demanding mechanical ventilation: A multicenter analysis of 250 cases

Author

Neumann, Bernhard, Angstwurm, Klemens, Mergenthaler, Philipp, Kohler, Siegfried, Schönenberger, Silvia, Bösel, Julian, Neumann, Ursula, Vidal, Amelie, Huttner, Hagen B., Gerner, Stefan T., Thieme, Andrea, Steinbrecher, Andreas, Dunkel, Juliane, Roth, Christian, Schneider, Haucke, Schimmel, Eik, Fuhrer, Hannah, Fahrendorf, Christine, Alberty, Anke, Zinke, Jan, Meisel, Andreas, Dohmen, Christian, and Stetefeld, Henning R.

Published
2020
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20. Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions

Author

Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Krumbholz, Markus, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Zettl, Uwe K., Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, Trebst, Corinna, Albrecht, P., Ayzenberg, I., Bayas, A., Bellmann-Strobl, J., Bischof, F., Bittner, S., Böttcher, T., Brettschneider, J., Buttmann, M., DSouza, M., Ettrich, B., Frank, B., Gass, A., Grothe, M., Guthke, K., Haarmann, A., Habedank, E., Hoffmann, F., Hoffmann, O., Hümmert, M.W., Junghans, J., Kaste, M., Kaulen, B., Kermer, P., Kern, P., Klotz, L., Köhler, W., Kolesilova, E., Korsen, M., Kowarik, M., Langel, S., Lee, D.H., Liebetrau, M., Luessi, F., Marouf, W., Meister, S., Melms, A., Metz, I., Münch, C., Niehaus, S., Pawlitzki, M., Pellkofer, H., Puhlmann, H.U., Pul, R., Retzlaf, N., Riedlinger, A., Rommer, P., Röpke, L., Rostásy, K., Rückriem, L., Ruschil, C., Schippling, S., Senel, M., Sieb, J.P., Sommer, C., Spreer, A., Steinbrecher, A., Stephanik, H., Stoppe, M., Süße, M., Tackenberg, B., Tünnerhoff, J., Veauthier, C., Walter, A., Wandinger, K.P., Warnke, C., Weber, M.S., Weissert, R., Wiendl, H., Wilke, C., Winkelmann, A., Yalachkov, Y., Young, K., Zentner, C., and Zipp, F.

Published
2018
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21. Real-world data on eculizumab treatment in NMOSD: high efficacy and potential challenges (P13-5.017)

Author

Ayzenberg, Ilya, primary, Asseyer, Susanna, additional, Lindenblatt, Gero, additional, Fischer, Katinka, additional, Pul, Refik, additional, Özalp, Sinem-Hilal, additional, Lohmann, Lisa, additional, Giglhuber, Katrin, additional, Häussler, Vivien, additional, Karenfort, Michael, additional, Hellwig, Kerstin, additional, Paul, Friedemann, additional, Bellmann-Strobl, Judith, additional, Otto, Carolin, additional, Ruprecht, Klemens, additional, Ziemssen, Tjalf, additional, Emmer, Alexander, additional, Rothhammer, Veit, additional, Nickel, Florian, additional, Angstwurm, Klemens, additional, Linker, Ralf, additional, Warnke, Clemens, additional, Jarius, Sven, additional, Korporal-Kuhnke, Mirjam, additional, Wildemann, Brigitte, additional, Wolff, Stephanie, additional, Seipelt, Maria, additional, Yalachkov, Yavor, additional, Retzlaff, Nele, additional, Zettl, Uwe, additional, Rommer, Paulus, additional, Kowarik, Markus, additional, Wickel, Jonathan, additional, Geis, Christian, additional, Hümmert, Martin W., additional, Trebst, Corinna, additional, Senel, Makbule, additional, Klotz, Luisa, additional, Gold, Ralf, additional, Kleinschnitz, Christoph, additional, Meuth, Sven, additional, Aktas, Orhan, additional, Berthele, Achim, additional, and Ringelstein, Marius, additional

Published
2023
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22. Cerebrospinal fluid in Borna disease virus 1 (BoDV-1) encephalitis

Author

Neumann, Bernhard, primary, Hierl, Andreas, additional, Wunderlich, Silke, additional, Meier, Helen, additional, Bauer, Christina, additional, Gerner, Stefan T., additional, Rieder, Georg, additional, Geis, Tobias, additional, Kunkel, Jürgen, additional, Bauswein, Markus, additional, Niller, Hans Helmut, additional, Schmidt, Barbara, additional, Rubbensroth, Dennis, additional, Beer, Martin, additional, Linker, Ralf A., additional, Jantsch, Jonathan, additional, and Angstwurm, Klemens, additional

Published
2023
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23. IFN-γ-Based ELISpot as a New Tool to Detect Human Infections with Borna Disease Virus 1 (BoDV-1): A Pilot Study

Author

Eidenschink, Lisa, primary, Knoll, Gertrud, additional, Tappe, Dennis, additional, Offner, Robert, additional, Drasch, Thomas, additional, Ehrl, Yvonne, additional, Banas, Bernhard, additional, Banas, Miriam C, additional, Niller, Hans Helmut, additional, Gessner, André, additional, Köstler, Josef, additional, Lampl, Benedikt M J, additional, Pregler, Matthias, additional, Völkl, Melanie, additional, Kunkel, Jürgen, additional, Neumann, Bernhard, additional, Angstwurm, Klemens, additional, Schmidt, Barbara, additional, and Bauswein, Markus, additional

Published
2023
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24. Human Infections with Borna Disease Virus 1 (BoDV-1) Primarily Lead to Severe Encephalitis: Further Evidence from the Seroepidemiological BoSOT Study in an Endemic Region in Southern Germany

Author

Bauswein, Markus, primary, Eidenschink, Lisa, additional, Knoll, Gertrud, additional, Neumann, Bernhard, additional, Angstwurm, Klemens, additional, Zoubaa, Saida, additional, Riemenschneider, Markus J, additional, Lampl, Benedikt M J, additional, Pregler, Matthias, additional, Niller, Hans Helmut, additional, Jantsch, Jonathan, additional, Gessner, André, additional, Eberhardt, Yvonne, additional, Huppertz, Gunnar, additional, Schramm, Torsten, additional, Kühn, Stefanie, additional, Koller, Michael, additional, Drasch, Thomas, additional, Ehrl, Yvonne, additional, Banas, Bernhard, additional, Offner, Robert, additional, Schmidt, Barbara, additional, and Banas, Miriam C., additional

Published
2023
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25. Early Tracheostomy Is Associated With Shorter Ventilation Time and Duration of ICU Stay in Patients With Myasthenic Crisis-A Multicenter Analysis

Author

Angstwurm, Klemens, Vidal, Amelie, Stetefeld, Henning, Dohmen, Christian, Mergenthaler, Philipp, Kohler, Siegfried, Schonenberger, Silvia, Bosel, Julian, Neumann, Ursula, Lee, De-Hyung, Gerner, Stefan T., Huttner, Hagen B., Thieme, Andrea, Dunkel, Juliane, Roth, Christian, Schneider, Hauke, Schimmel, Eik, Reichmann, Heinz, Fuhrer, Hannah, Berger, Benjamin, Kleiter, Ingo, Schneider-Gold, Christiane, Alberty, Anke, Zinke, Jan, Schalke, Berthold, Steinbrecher, Andreas, Meisel, Andreas, Neumann, Bernhard, Angstwurm, Klemens, Vidal, Amelie, Stetefeld, Henning, Dohmen, Christian, Mergenthaler, Philipp, Kohler, Siegfried, Schonenberger, Silvia, Bosel, Julian, Neumann, Ursula, Lee, De-Hyung, Gerner, Stefan T., Huttner, Hagen B., Thieme, Andrea, Dunkel, Juliane, Roth, Christian, Schneider, Hauke, Schimmel, Eik, Reichmann, Heinz, Fuhrer, Hannah, Berger, Benjamin, Kleiter, Ingo, Schneider-Gold, Christiane, Alberty, Anke, Zinke, Jan, Schalke, Berthold, Steinbrecher, Andreas, Meisel, Andreas, and Neumann, Bernhard

Abstract

Background: Myasthenic crisis (MC) requiring mechanical ventilation (MV) is a rare and serious complication of myasthenia gravis. Here we analyzed the frequency of performed tracheostomies, risk factors correlating with a tracheostomy, as well as the impact of an early tracheostomy on ventilation time and ICU length of stay (LOS) in MC. Methods: Retrospective chart review on patients treated for MC in 12 German neurological departments between 2006 and 2015 to assess demographic/diagnostic data, rates and timing of tracheostomy and outcome. Results: In 107 out of 215 MC (49.8%), a tracheostomy was performed. Patients without tracheostomy were more likely to have an early-onset myasthenia gravis (27 [25.2%] vs 12 [11.5%], p = 0.01). Patients receiving a tracheostomy, however, were more frequently suffering from multiple comorbidities (20 [18.7%] vs 9 [8.3%], p = 0.03) and also the ventilation time (34.4 days +/- 27.7 versus 7.9 +/- 7.8, p < 0.0001) and ICU-LOS (34.8 days +/- 25.5 versus 12.1 +/- 8.0, p < 0.0001) was significantly longer than in non-tracheostomized patients. Demographics and characteristics of the course of the disease up to the crisis were not significantly different between patients with an early (within 10 days) compared to a late tracheostomy. However, an early tracheostomy correlated with a shorter duration of MV at ICU (26.2 days +/- 18.1 versus 42.0 +/- 33.1, p = 0.006), and ICU-LOS (26.2 days +/- 14.6 versus 42.3 +/- 33.0, p = 0.003). Conclusion: Half of the ventilated patients with MC required a tracheostomy. Poorer health condition before the crisis and late-onset MG were associated with a tracheostomy. An early tracheostomy (<= day 10), however, was associated with a shorter duration of MV and ICU-LOS by 2 weeks.

Published
2022

27. Additional file 1 of Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

Author

Jarius, Sven, Pache, Florence, K��rtvelyessy, Peter, Jel��i��, Ilijas, Stettner, Mark, Franciotta, Diego, Keller, Emanuela, Neumann, Bernhard, Ringelstein, Marius, Senel, Makbule, Regeniter, Axel, Kalantzis, Rea, Willms, Jan F., Berthele, Achim, Busch, Markus, Capobianco, Marco, Eisele, Amanda, Reichen, Ina, Dersch, Rick, Rauer, Sebastian, Sandner, Katharina, Ayzenberg, Ilya, Gross, Catharina C., Hegen, Harald, Khalil, Michael, Kleiter, Ingo, Lenhard, Thorsten, Haas, J��rgen, Aktas, Orhan, Angstwurm, Klemens, Kleinschnitz, Christoph, Lewerenz, Jan, Tumani, Hayrettin, Paul, Friedemann, Stangel, Martin, Ruprecht, Klemens, and Wildemann, Brigitte

Abstract

Additional file 1. Table S1. Patient and subgroup characteristics.

Published
2022
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28. Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections

Author

Neumann, Bernhard, Angstwurm, Klemens, Linker, Ralf A., Knoll, Gertrud, Eidenschink, Lisa, Rubbenstroth, Dennis, Schlottau, Kore, Beer, Martin, Schreiner, Patrick, Soutschek, Erwin, Böhmer, Merle M., Lampl, Benedikt M.J., Pregler, Matthias, Scheiter, Alexander, Evert, Katja, Zoubaa, Saida, Riemenschneider, Markus J., Asbach, Benedikt, Gessner, André, Niller, Hans Helmut, Schmidt, Barbara, and Bauswein, Markus

Subjects
Borna disease virus 1, encephalitis, encephalopathy, zoonosis, recombinant protein, diagnostics, humoral immune response, antibodies, ELISA, encephalitis, 610 Medizin, General Biochemistry, Genetics and Molecular Biology, Antibodies, Viral Proteins, Report, Chlorocebus aethiops, diagnostics, 570 Biowissenschaften, Biologie, Animals, Humans, Borna disease virus, Vero Cells, Aged, ddc:610, Borna disease virus 1, zoonosis, encephalopathy, Phosphoproteins, humoral immune response, Recombinant Proteins, Nucleoproteins, Borna Disease, ELISA, ddc:570, recombinant protein
Abstract

Summary Borna disease virus 1 (BoDV-1) causes rare but often fatal encephalitis in humans. Late diagnosis prohibits an experimental therapeutic approach. Here, we report a recent case of fatal BoDV-1 infection diagnosed on day 12 after hospitalization by detection of BoDV-1 RNA in the cerebrospinal fluid. In a retrospective analysis, we detect BoDV-1 RNA 1 day after hospital admission when the cell count in the cerebrospinal fluid is still normal. We develop a new ELISA using recombinant BoDV-1 nucleoprotein, phosphoprotein, and accessory protein X to detect seroconversion on day 12. Antibody responses are also shown in seven previously confirmed cases. The individual BoDV-1 antibody profiles show variability, but the usage of three different BoDV-1 antigens results in a more sensitive diagnostic tool. Our findings demonstrate that early detection of BoDV-1 RNA in cerebrospinal fluid and the presence of antibodies against at least two different viral antigens contribute to BoDV-1 diagnosis. Physicians in endemic regions should consider BoDV-1 infection in cases of unclear encephalopathy and initiate appropriate diagnostics at an early stage., Graphical abstract, Highlights • Borna disease virus 1 causes fatal encephalitis upon zoonotic spillover infections • An ELISA system using recombinant BoDV-1 N, X, and P proteins has been established • Antibodies against at least two different BoDV-1 antigens corroborate seroconversion • Early detection of viral RNA and antibodies could contribute to BoDV-1 diagnosis, Neumann et al. provide data on antibody responses to Borna disease virus 1 in eight cases of fatal encephalitis based on a newly developed ELISA using recombinant BoDV-1 nucleoprotein, phosphoprotein, and accessory protein X. The presence of antibodies against at least two different viral antigens contributes to BoDV-1 diagnosis.

Published
2022

29. Seronegative myasthenic crisis: a multicenter analysis

Author

Mergenthaler, Philipp, Stetefeld, Henning R., Dohmen, Christian, Kohler, Siegfried, Schönenberger, Silvia, Bösel, Julian, Gerner, Stefan T., Huttner, Hagen B., Schneider, Hauke, Reichmann, Heinz, Fuhrer, Hannah, Berger, Benjamin, Zinke, Jan, Alberty, Anke, Kleiter, Ingo, Schneider-Gold, Christiane, Roth, Christian, Dunkel, Juliane, Steinbrecher, Andreas, Thieme, Andrea, Lee, De-Hyung, Linker, Ralf A., Angstwurm, Klemens, Meisel, Andreas, and Neumann, Bernhard

Subjects
Male, ddc:610, 610 Medizin, Respiration, Artificial, humanities, Neurology, Myasthenia Gravis, Myasthenia gravis · Myasthenic crisis · Antibody status · Seronegative · Outcome, Humans, Female, Receptors, Cholinergic, Neurology (clinical), Autoantibodies, Retrospective Studies
Abstract

Myasthenic crisis (MC) is a life-threatening condition for patients with myasthenia gravis (MG). Seronegative patients represent around 10–15% of MG, but data on outcome of seronegative MCs are lacking. We performed a subgroup analysis of patients who presented with MC with either acetylcholine-receptor-antibody-positive MG (AChR-MG) or seronegative MG between 2006 and 2015 in a retrospective German multicenter study. We identified 15 seronegative MG patients with 17 MCs and 142 AChR-MG with 159 MCs. Seronegative MCs were younger (54.3 ± 14.5 vs 66.5 ± 16.3 years; p = 0.0037), had a higher rate of thymus hyperplasia (29.4% vs 3.1%; p = 0.0009), and were more likely to be female (58.8% vs 37.7%; p = 0.12) compared to AChR-MCs. Time between diagnosis of MG and MC was significantly longer in seronegative patients (8.2 ± 7.6 vs 3.1 ± 4.4 years; p p = 0.94) and length of stay at intensive care unit (17.6 ± 15.2 vs 17.8 ± 15.4 days; p = 0.96), or in-hospital mortality (11.8% vs. 10.1%; p = 0.69). We conclude that MC in seronegative MG affects younger patients after a longer period of disease, but that crisis treatment efficacy and outcome do not differ compared to AChR-MCs.

Published
2021

30. Neuromyelitis Optica: Evaluation of 871 Attacks and 1,153 Treatment Courses

Author

Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Wegner, Brigitte, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Krumbholz, Markus, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Winkelmann, Alexander, Marouf, Wael, Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, and Trebst, Corinna

Published
2016
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33. MuSK-antibodies are associated with worse outcome in myasthenic crisis requiring mechanical ventilation

Author

Konig, Nicole, Stetefeld, Henning R., Dohmen, Christian, Mergenthaler, Philipp, Kohler, Siegfried, Schonenberger, Silvia, Bosel, Julian, Lee, De-Hyung, Gerner, Stefan T., Huttner, Hagen B., Schneider, Hauke, Reichmann, Heinz, Fuhrer, Hannah, Berger, Benjamin, Zinke, Jan, Alberty, Anke, Kleiter, Ingo, Schneider-Gold, Christiane, Roth, Christian, Dunkel, Juliane, Steinbrecher, Andreas, Thieme, Andrea, Schlachetzki, Felix, Linker, Ralf A., Angstwurm, Klemens, Meisel, Andreas, Neumann, Bernhard, Konig, Nicole, Stetefeld, Henning R., Dohmen, Christian, Mergenthaler, Philipp, Kohler, Siegfried, Schonenberger, Silvia, Bosel, Julian, Lee, De-Hyung, Gerner, Stefan T., Huttner, Hagen B., Schneider, Hauke, Reichmann, Heinz, Fuhrer, Hannah, Berger, Benjamin, Zinke, Jan, Alberty, Anke, Kleiter, Ingo, Schneider-Gold, Christiane, Roth, Christian, Dunkel, Juliane, Steinbrecher, Andreas, Thieme, Andrea, Schlachetzki, Felix, Linker, Ralf A., Angstwurm, Klemens, Meisel, Andreas, and Neumann, Bernhard

Abstract

Myasthenic crisis (MC) is a life-threatening condition for patients with myasthenia gravis (MG). Muscle-specific kinase-antibodies (MuSK-ABs) are detected in similar to 6% of MG, but data on outcome of MuSK-MCs are still lacking. We made a subgroup analysis of patients who presented with MC with either acetylcholine-receptor-antibody positive MG (AchR-MG) or MuSK-MG between 2006 and 2015 in a retrospective German multicenter study. We identified 19 MuSK-AB associated MCs in 15 patients and 161 MCs in 144 patients with AchR-ABs only. In contrast to patients with AchR-AB, MuSK-AB patients were more often female (p = 0.05, OR = 2.74) and classified as Myasthenia Gravis Foundation of America-class IV before crisis (p = 0.04, OR = 3.25). MuSK-AB patients suffer more often from multiple chronic disease (p = 0.016, OR = 4.87) and were treated more invasively in terms of plasma exchanging therapies (not significant). The number of days of mechanical ventilation (MV) (43.0 +/- 53.1 vs. 17.4 +/- 18; p < 0.0001), days on an intensive care unit (ICU) (45.3 +/- 49.5 vs. 21.2 +/- 19.7; p < 0.0001), and hospital-length of stay (LOS) (55.9 +/- 47.6 vs. 28.8 +/- 20.9 days; p < 0.0001) were significantly increased in MuSK-MC. Remarkable is that these changes were mainly due to patients with MusK-ABs only, whereas patients' outcome with both antibodies was similar to AchR-MCs. Furthermore, our data showed a shortened duration of MV after treatment with plasma exchanging therapies compared to treatment with intravenous immunoglobulin in MuSK-MCs. We conclude that MuSK-AB-status is associated with a longer need of MV, ICU-LOS, and hospital-LOS in MC, and therefore recommend early initiation of a disease-specific therapy.

Published
2021

36. Short term relapse risk after switching from natalizumab to ocrelizumab or cladribine – an international cohort study (1712)

Author

Treffts, Johanna, primary, Van Kesteren, Yan, additional, Thiel, Sandra, additional, Stahmann, Alexander, additional, Magyari, Melinda, additional, Berthele, Achim, additional, Giglhuber, Katrin, additional, Bittner, Stefan, additional, Ellwardt, Erik, additional, Angstwurm, Klemens, additional, Tackenberg, Björn, additional, Jurs, Jan, additional, Viehover, Andrea, additional, Klotz, Luisa, additional, Theis, Lena, additional, Gold, Ralf, additional, Ellenberger, David, additional, and Hellwig, Kerstin, additional

Published
2021
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37. Short term relapse risk after switching from fingolimod to ocrelizumab or cladribine - an international cohort study (1822)

Author

Van Kesteren, Yan, primary, Treffts, Johanna, additional, Thiel, Sandra, additional, Stahmann, Alexander, additional, Theis, Lena, additional, Magyari, Melinda, additional, Celius, Elisabeth, additional, Berthele, Achim, additional, Giglhuber, Katrin, additional, Angstwurm, Klemens, additional, Klotz, Luisa, additional, Ellwardt, Erik, additional, Bittner, Stefan, additional, Viehöver, Andrea, additional, Tackenberg, Björn, additional, Jürß, Jan, additional, Gold, Ralf, additional, Ellenberger, David, additional, and Hellwig, Kerstin, additional

Published
2021
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38. Genome-wide association study identifies two new loci associated with anti-NMDAR encephalitis

Author

Tietz, Anja K, primary, Angstwurm, Klemens, additional, Baumgartner, Tobias, additional, Doppler, Kathrin, additional, Eisenhut, Katharina, additional, Elišák, Martin, additional, Franke, Andre, additional, Golombeck, Kristin S, additional, Handreka, Robert, additional, Kaufmann, Max, additional, Kraemer, Markus, additional, Kraft, Andrea, additional, Lewerenz, Jan, additional, Lieb, Wolfgang, additional, Madlener, Marie, additional, Melzer, Nico, additional, Mojzisova, Hana, additional, Möller, Peter, additional, Pfefferkorn, Thomas, additional, Prüss, Harald, additional, Rostásy, Kevin, additional, Schnegelsberg, Margret, additional, Schröder, Ina, additional, Siebenbrodt, Kai, additional, Sühs, Kurt-Wolfram, additional, Wandinger, Klaus-Peter, additional, Wickel, Jonathan, additional, Leypoldt, Frank, additional, and Kuhlenbäumer, Gregor, additional

Published
2021
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39. Bornavirus encephalitis shows a characteristic MR phenotype in humans

Author

Wiesinger, Isabel, Finck, Tom, Liesche-Starnecker, Friederike, Probst, Monika, Bette, Stefanie, Ruf, Viktoria, Wendl, Christina, Dorn, Franziska, Angstwurm, Klemens, Schlegel, Jürgen, Zimmer, Claus, Wiestler, Benedikt, and Bornavirus-Encephalitis Study Group, .

Subjects
ddc:610, 610 Medizin
Abstract

Objective The number of diagnosed fatal encephalitis cases in humans caused by the classical Borna disease virus (BoDV-1) has been increasing, ever since it was proved that BoDV-1 can cause human infections. However, awareness of this entity is low, and a specific imaging pattern has not yet been identified. We therefore provide the first comprehensive description of the morphology of human BoDV-1 encephalitis, with histopathological verification of imaging abnormalities. Methods In an institutional review board-approved multicenter study, we carried out a retrospective analysis of 55 magnetic resonance imaging (MRI) examinations of 19 patients with confirmed BoDV-1 encephalitis. Fifty brain regions were analyzed systematically (T1w, T2w, T2*w, T1w + Gd, and DWI), in order to discern a specific pattern of inflammation. Histopathological analysis of 25 locations in one patient served as correlation for MRI abnormalities. Results Baseline imaging, acquired at a mean of 11 +/- 10 days after symptom onset, in addition to follow-up scans of 16 patients, revealed characteristic T2 hyperintensities with a predilection for the head of the caudate nucleus, insula, and cortical spread to the limbic system, whereas the occipital lobes and cerebellar hemispheres were unaffected. This gradient was confirmed by histology. Nine patients (47.4%) developed T1 hyperintensities of the basal ganglia, corresponding to accumulated lipid phagocytes on histology and typical for late-stage necrosis. Interpretation BoDV-1 encephalitis shows a distinct pattern of inflammation in both the early and late stages of the disease. Its appearance can mimic sporadic Creutzfeldt-Jakob disease on MRI and should be considered a differential diagnosis in the case of atypical clinical presentation. ANN NEUROL 2020

Published
2020

40. Organ-related and miscellaneous complications

Author

Hildebrandt, Gerhard C., primary, Munker, Reinhold, additional, Duffner, Ulrich, additional, Wolff, Daniel, additional, Stadler, Michael, additional, Dietrich-Ntoukas, Tina, additional, Angstwurm, Klemens, additional, Sun, Amanda, additional, Nair, Binu, additional, Lazarus, Hillard M., additional, and Atkinson, Kerry, additional

Published
2013
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42. Early Tracheostomy Is Associated With Shorter Ventilation Time and Duration of ICU Stay in Patients With Myasthenic Crisis—A Multicenter Analysis

Author

Angstwurm, Klemens, primary, Vidal, Amelie, additional, Stetefeld, Henning, additional, Dohmen, Christian, additional, Mergenthaler, Philipp, additional, Kohler, Siegfried, additional, Schönenberger, Silvia, additional, Bösel, Julian, additional, Neumann, Ursula, additional, Lee, De-Hyung, additional, Gerner, Stefan T., additional, Huttner, Hagen B., additional, Thieme, Andrea, additional, Dunkel, Juliane, additional, Roth, Christian, additional, Schneider, Hauke, additional, Schimmel, Eik, additional, Reichmann, Heinz, additional, Fuhrer, Hannah, additional, Berger, Benjamin, additional, Kleiter, Ingo, additional, Schneider-Gold, Christiane, additional, Alberty, Anke, additional, Zinke, Jan, additional, Schalke, Berthold, additional, Steinbrecher, Andreas, additional, Meisel, Andreas, additional, and Neumann, Bernhard, additional

Published
2020
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