15 results on '"Angotti M"'
Search Results
2. Prognoserelevante Faktoren der K-RAS G12C Lungenkarzinompatienten für die Therapieentscheidung.
- Author
-
Kurz, S, Lüders, H, Grohé, C, and Angotti, M
- Published
- 2024
- Full Text
- View/download PDF
3. Neuropsychological profile in Italian children with neurofibromatosis type 1 (NF1) and their relationships with neuroradiological data: Preliminary results
- Author
-
Parmeggiani, A., primary, Boiani, F., additional, Capponi, S., additional, Duca, M., additional, Angotti, M., additional, Pignataro, V., additional, Sacrato, L., additional, Spinardi, L., additional, Vara, G., additional, Maltoni, L., additional, Cecconi, I., additional, Pastore Trossello, M., additional, and Franzoni, E., additional
- Published
- 2018
- Full Text
- View/download PDF
4. Autism spectrum disorder and anorexia nervosa: an Italian prospective study
- Author
-
Elisabetta Malaspina, Marida Angotti, Letizia Terenzi, Paola Gualandi, Duccio Maria Cordelli, Antonia Parmeggiani, Veronica Pignataro, Emilio Franzoni, Leonardo Sacrato, Jacopo Pruccoli, Altea Solari, Pruccoli J., Solari A., Terenzi L., Malaspina E., Angotti M., Pignataro V., Gualandi P., Sacrato L., Cordelli D.M., Franzoni E., and Parmeggiani A.
- Subjects
Male ,Adolescent ,medicine.medical_treatment ,Anorexia nervosa ,behavioral disciplines and activities ,ADOS-2 ,03 medical and health sciences ,Young Adult ,BMI ,0302 clinical medicine ,Surveys and Questionnaires ,mental disorders ,medicine ,Humans ,Prospective Studies ,Autism spectrum disorder ,Prospective cohort study ,Antipsychotic ,EDI-3 ,Psychiatric Status Rating Scales ,business.industry ,Research ,lcsh:RJ1-570 ,lcsh:Pediatrics ,General Medicine ,medicine.disease ,Comorbidity ,030227 psychiatry ,Eating disorders ,Italy ,Autism ,Female ,business ,AQ ,030217 neurology & neurosurgery ,Psychopathology ,Clinical psychology - Abstract
BackgroundPotential overlaps exist between psychopathological features of Anorexia Nervosa (AN) and Autism Spectrum Disorder (ASD). The impact of malnutrition on autistic traits in patients with AN should be considered. This study investigates possible associations among the psychopathology of Eating Disorders (EDs), ASD traits and BMI in a group of young patients with AN, using the EDI-3 (Eating Disorder Inventory-3) test and gold-standard measures for ASD.MethodsProspective study involving 23 inpatients admitted to an Italian Centre for paediatric ED. ASD traits and ED psychopathology were assessed administering the ADOS-2 (Autism Diagnostic Observation Schedule-2), AQ (Autism Quotient) and EDI-3 tests. Both present and past autistic traits were investigated using different versions of AQ. Correlations were adjusted for BMI, Obsessive Compulsive Disorder (OCD) comorbidity and concurrent antipsychotic treatments.ResultsAn ASD diagnosis was possible in 22% of patients. Significant correlations were documented between ASD traits and ED psychopathology: AQ total-Interpersonal problems (IPC) (p = 0.041); AQ total-Global psychological maladjustment (GMPC) (p = 0.027); AQ social skills-Ineffectiveness (IC) (p = 0.018); AQ social skills-IPC (p = 0.019); AQ social skills-Affective problems (APC) (p = 0.025); AQ social skills-GMPC (p = 0.007); AQ attention switching-IPC (p = 0.020); ADOS-2 imagination-IC (p = 0.035). These correlations were independent of BMI, OCD and antipsychotic treatments.ConclusionsASD traits presented high prevalence in a group of young inpatients with AN. These traits were significantly correlated to 4 specific EDI-3 subscales and independent of BMI. This is the first study to investigate the relationship between ASD traits as measured with gold-standard measures, EDI-3 scores, and BMI.
- Published
- 2021
5. Cognitive, Behavioral, and Sensory Profile of Pallister–Killian Syndrome: A Prospective Study of 22 Individuals
- Author
-
Anna Fetta, Luca Soliani, Alessia Trevisan, Rosa Pugliano, Emilia Ricci, Veronica Di Pisa, Veronica Pignataro, Marida Angotti, Alessandro Rocca, Bianca Salce, Maria Margherita Mancardi, Lucio Giordano, Dario Pruna, Antonia Parmeggiani, Duccio Maria Cordelli, Fetta A., Soliani L., Trevisan A., Pugliano R., Ricci Emilia, Di Pisa V., Pignataro V., Angotti M., Rocca Alessandro, Salce B., Mancardi M.M., Giordano Lucio, Pruna D., Parmeggiani Antonia, and Cordelli D.M.
- Subjects
Chromosomes, Human, Pair 12 ,Bayley-3 ,Vineland-II ,Stereotypie ,Chromosome Disorders ,Tetrasomy 12p ,PKS ,Cognition ,Intellectual Disability ,Genetics ,Humans ,Prospective Studies ,tetrasomy 12p ,Sensory Profile 2 ,stereotypies ,Genetics (clinical) - Abstract
Background: Developmental delay and intellectual disability are two pivotal elements of the phenotype of Pallister–Killian Syndrome (PKS). Our study aims to define the cognitive, adaptive, behavioral, and sensory profile of these patients and to evaluate possible correlations between the different aspects investigated and with the main clinical and demographic variables. Methods: Individuals of any age with genetically confirmed PKS were recruited. Those ≤ 42 months were administered the Bayley Scales of Infant and Toddler Development Third Edition (Bayley-III), and those > 42 months the Vineland Adaptive Behavior Scales—Second Edition (Vineland-II). Stereotyped behaviors (Stereotypy Severity Scale, SSS) and aggressive behaviors (Behavior Problems Inventory—Short Version, BPIs) were assessed in all subjects > 1 year; sensory profile (Child Sensory Profile 2, C-SP2) in all aged 2–18 years. Results: Twenty-two subjects were enrolled (11 F/11 M; age 9 months to 28 years). All subjects ≤ 42 months had psychomotor developmental delay. Of the subjects > 42 months, 15 had low IQ deviation, and 1 in the normal range. Stereotypies were frequent (median SSS-total score 25/68). Lower Vineland-II values corresponded to greater intensity and frequency of stereotypies (p = 0.004 and p = 0.003), and self-injurious behaviors (p = 0.002 and p = 0.002). Patients with severe low vision had greater interference of stereotypies (p = 0.027), and frequency and severity of aggressive behaviors (p = 0.026; p = 0.032). The C-SP2, while not homogeneous across subjects, showed prevalence of low registration and sensory seeking profiles and hypersensitivity to tactile and auditory stimuli. Lower Vineland-II scores correlated with higher Registration scores (p = 0.041), while stereotypies were more frequent and severe in case of high auditory sensitivity (p = 0.019; p = 0.007). Finally, greater sleep impairment correlated with stereotypies and self-injurious behaviors, and lower Vineland-II scores. Conclusions: The present study provides a further step in the investigation of the etiopathogenesis of the syndrome. Furthermore, these aspects could guide rehabilitation therapy through the identification of targeted protocols.
- Published
- 2022
6. « Henricus Pistor de Lewis, ses lectures, ses livres et sa bibliothèque. Portrait d’un passeur de textes »
- Author
-
ANGOTTI, Claire, ANGOTTI, Claire, C. Angotti, M. Brînzei, M. Teeuwen, Centre d'études et de recherche en histoire culturelle - EA 2616 (CERHIC), Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), C. Angotti, M. Brînzei, and M. Teeuwen
- Subjects
[SHS.HIST] Humanities and Social Sciences/History ,[SHS.HIST]Humanities and Social Sciences/History ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2012
7. Cognitive, Behavioral, and Sensory Profile of Pallister-Killian Syndrome: A Prospective Study of 22 Individuals.
- Author
-
Fetta A, Soliani L, Trevisan A, Pugliano R, Ricci E, Di Pisa V, Pignataro V, Angotti M, Rocca A, Salce B, Mancardi MM, Giordano L, Pruna D, Parmeggiani A, and Cordelli DM
- Subjects
- Chromosomes, Human, Pair 12, Cognition, Humans, Prospective Studies, Chromosome Disorders genetics, Intellectual Disability genetics
- Abstract
Background: Developmental delay and intellectual disability are two pivotal elements of the phenotype of Pallister-Killian Syndrome (PKS). Our study aims to define the cognitive, adaptive, behavioral, and sensory profile of these patients and to evaluate possible correlations between the different aspects investigated and with the main clinical and demographic variables., Methods: Individuals of any age with genetically confirmed PKS were recruited. Those ≤ 42 months were administered the Bayley Scales of Infant and Toddler Development Third Edition (Bayley-III), and those > 42 months the Vineland Adaptive Behavior Scales-Second Edition (Vineland-II). Stereotyped behaviors (Stereotypy Severity Scale, SSS) and aggressive behaviors (Behavior Problems Inventory-Short Version, BPIs) were assessed in all subjects > 1 year; sensory profile (Child Sensory Profile 2, C-SP2) in all aged 2-18 years., Results: Twenty-two subjects were enrolled (11 F/11 M; age 9 months to 28 years). All subjects ≤ 42 months had psychomotor developmental delay. Of the subjects > 42 months, 15 had low IQ deviation, and 1 in the normal range. Stereotypies were frequent (median SSS-total score 25/68). Lower Vineland-II values corresponded to greater intensity and frequency of stereotypies ( p = 0.004 and p = 0.003), and self-injurious behaviors ( p = 0.002 and p = 0.002). Patients with severe low vision had greater interference of stereotypies ( p = 0.027), and frequency and severity of aggressive behaviors ( p = 0.026; p = 0.032). The C-SP2, while not homogeneous across subjects, showed prevalence of low registration and sensory seeking profiles and hypersensitivity to tactile and auditory stimuli. Lower Vineland-II scores correlated with higher Registration scores ( p = 0.041), while stereotypies were more frequent and severe in case of high auditory sensitivity ( p = 0.019; p = 0.007). Finally, greater sleep impairment correlated with stereotypies and self-injurious behaviors, and lower Vineland-II scores., Conclusions: The present study provides a further step in the investigation of the etiopathogenesis of the syndrome. Furthermore, these aspects could guide rehabilitation therapy through the identification of targeted protocols.
- Published
- 2022
- Full Text
- View/download PDF
8. COVID-19 and its Impact on Back Pain.
- Author
-
Angotti M, Mallow GM, Wong A, Haldeman S, An HS, and Samartzis D
- Published
- 2022
- Full Text
- View/download PDF
9. Relationship between Sensory Alterations and Repetitive Behaviours in Children with Autism Spectrum Disorders: A Parents' Questionnaire Based Study.
- Author
-
Fetta A, Carati E, Moneti L, Pignataro V, Angotti M, Bardasi MC, Cordelli DM, Franzoni E, and Parmeggiani A
- Abstract
The relationship between sensory profile and repetitive behaviours in autism spectrum disorder (ASD) has long been known. However, there is no consensus on the type of relationship that exists between them. This monocentric retrospective-prospective observational study aimed (a) to detect a clinical correlation between the severity of repetitive behaviours and the alterations of sensory profile in a sample of 50 children diagnosed with ASD; (b) to evaluate how different patterns of stereotypies and sensory alterations correlate with each other and with the main clinical-instrumental variables in the same sample. We enrolled 29 children in the retrospective phase of the study and 21 in the prospective phase. The Repetitive Behaviour Scale-Revised (RBS-R) and the Short Sensory Profile (SSP) were administered to the caregivers, and clinical-instrumental data were collected. SSP and RBS-R total scores directly correlated with a high significance rate. Among the subscales, the strongest correlations involved "Visual/Auditory Sensitivity", related to "Stereotyped Behaviour" and "Sameness Behaviour". "Under-Responsive/Seeks Sensation" related to "Stereotyped Behaviour". Sex and intellectual disability significantly influenced both the stereotypies and the sensory alterations of the examined population. In conclusion, this study provides new insights into the relationship between sensory alterations and repetitive behaviours in ASD children by using direct medical observation and parent observation.
- Published
- 2021
- Full Text
- View/download PDF
10. Phonic and Motor Stereotypies in Autism Spectrum Disorder: Video Analysis and Neurological Characterization.
- Author
-
Lanzarini E, Pruccoli J, Grimandi I, Spadoni C, Angotti M, Pignataro V, Sacrato L, Franzoni E, and Parmeggiani A
- Abstract
Stereotypies are among the core symptoms of Autism spectrum disorder (ASD) and can cause significant clinical impairment. At present, phonic stereotypies in ASD have been scarcely explored. This study investigates the frequency, variability, and typologies of phonic and motor stereotypies in children with ASD and their association with clinical neurological variables. We examined 35 patients by recording standardized video sessions and administering the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). Phonic stereotypies were present in 83.0% of the patients. The most prevalent subtypes were noncommunicative vocalizations (60.0%), single syllables (37.1%), and echolalic stereotypies (22.9%). Noncommunicative vocalizations were more frequent in nonverbal patients (OR = 4.629, p = 0.008), while echolalic stereotypies were more represented in verbal patients (OR = 0.279, p = 0.028). Patients with intellectual disability (ID) showed a higher number (F(1,26) = 9.406, p = 0.005) and variability (F(1,25) = 7.174, p = 0.013) of motor stereotypies, with a higher number (F(1,26) = 13.268, p = 0.005) and variability (F(1,26) = 9.490, p = 0.005) of stereotypies involving the head/trunk/shoulders category. Patients with guttural stereotypies showed a higher variability of total motor stereotypies (OR = 1.487, p = 0.032) and self-directed motor stereotypies (OR = 4.389, p = 0.042). These results, combined with a standardized video-analysis, document the frequency and variability of phonic stereotypies among children with ASD. Correlations between specific phonic stereotypies and verbal abilities should be investigated further.
- Published
- 2021
- Full Text
- View/download PDF
11. Autism spectrum disorder and anorexia nervosa: an Italian prospective study.
- Author
-
Pruccoli J, Solari A, Terenzi L, Malaspina E, Angotti M, Pignataro V, Gualandi P, Sacrato L, Cordelli DM, Franzoni E, and Parmeggiani A
- Subjects
- Adolescent, Anorexia Nervosa psychology, Autism Spectrum Disorder psychology, Female, Humans, Italy, Male, Prospective Studies, Psychiatric Status Rating Scales, Surveys and Questionnaires, Young Adult, Anorexia Nervosa complications, Autism Spectrum Disorder complications, Autism Spectrum Disorder diagnosis
- Abstract
Background: Potential overlaps exist between psychopathological features of Anorexia Nervosa (AN) and Autism Spectrum Disorder (ASD). The impact of malnutrition on autistic traits in patients with AN should be considered. This study investigates possible associations among the psychopathology of Eating Disorders (EDs), ASD traits and BMI in a group of young patients with AN, using the EDI-3 (Eating Disorder Inventory-3) test and gold-standard measures for ASD., Methods: Prospective study involving 23 inpatients admitted to an Italian Centre for paediatric ED. ASD traits and ED psychopathology were assessed administering the ADOS-2 (Autism Diagnostic Observation Schedule-2), AQ (Autism Quotient) and EDI-3 tests. Both present and past autistic traits were investigated using different versions of AQ. Correlations were adjusted for BMI, Obsessive Compulsive Disorder (OCD) comorbidity and concurrent antipsychotic treatments., Results: An ASD diagnosis was possible in 22% of patients. Significant correlations were documented between ASD traits and ED psychopathology: AQ total-Interpersonal problems (IPC) (p = 0.041); AQ total-Global psychological maladjustment (GMPC) (p = 0.027); AQ social skills-Ineffectiveness (IC) (p = 0.018); AQ social skills-IPC (p = 0.019); AQ social skills-Affective problems (APC) (p = 0.025); AQ social skills-GMPC (p = 0.007); AQ attention switching-IPC (p = 0.020); ADOS-2 imagination-IC (p = 0.035). These correlations were independent of BMI, OCD and antipsychotic treatments., Conclusions: ASD traits presented high prevalence in a group of young inpatients with AN. These traits were significantly correlated to 4 specific EDI-3 subscales and independent of BMI. This is the first study to investigate the relationship between ASD traits as measured with gold-standard measures, EDI-3 scores, and BMI.
- Published
- 2021
- Full Text
- View/download PDF
12. The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors.
- Author
-
Müller-Vieira U, Angotti M, and Hartmann RW
- Subjects
- Adrenal Cortex cytology, Adrenal Cortex drug effects, Adrenal Cortex enzymology, Aldosterone metabolism, Aromatase Inhibitors pharmacology, Drug Evaluation, Preclinical, Enzyme Inhibitors chemistry, Fadrozole pharmacology, Humans, Steroids analysis, Steroids metabolism, Cell Line, Tumor, Cytochrome P-450 CYP11B2 antagonists & inhibitors, Enzyme Inhibitors pharmacology, Steroid 11-beta-Hydroxylase antagonists & inhibitors
- Abstract
Aldosterone plays a key role in salt and water homeostasis but is also involved in the development and progression of congestive heart failure and myocardial fibrosis. As a new pharmacological strategy for the treatment of these diseases, we propose the inhibition of the key enzyme of mineralcorticoid formation, CYP11B2 (aldosterone synthase). For studies of the effects of CYP11B2 inhibitors on the adrenal cortex, we selected the NCI-H295R cell line which expresses most of the key enzymes necessary for steroidogenesis. To evaluate this cell line as a test system for effects and side effects of CYP inhibitors, we established assays using radiolabeled substrates of CYP11B2 and CYP11B1 and subsequently tested a series of CYP11B2 inhibitors including the CYP19 inhibitor fadrozole. Fadrozole and compounds 6, 9 and 10 were more potent towards CYP11B2 compared to CYP11B1 with IC(50) values in the nanomolar range. To analyze their overall effect, the formation of steroids in the cell culture supernatant was monitored. All compounds led to a concentration-dependent reduction of the aldosterone secretion but also reduced the formation of cortisol and androgens. In conclusion, the H295R cell line is a suitable tool for the prediction of overall side effects of CYP11B2 inhibitors on steroidogenesis.
- Published
- 2005
- Full Text
- View/download PDF
13. Effect of 2-(4-aminophenylmethyl)-6-hydroxy-3, 4-dihydronaphthalen-1(2H)-one on all-trans and 13-cis-retinoic acid levels in plasma quantified by high perfomance liquid chromatography coupled to tandem mass spectrometry.
- Author
-
Angotti M, Hartmann RW, Kirby AJ, Simons C, Nicholls PJ, Sewell RD, and Smith HJ
- Subjects
- Animals, Isotretinoin chemistry, Ketoconazole metabolism, Ketoconazole pharmacology, Male, Mass Spectrometry, Rats, Rats, Inbred WF, Tetralones metabolism, Tetralones pharmacology, Tretinoin chemistry, Chromatography, High Pressure Liquid methods, Isotretinoin blood, Naphthalenes pharmacology, Spectrometry, Mass, Electrospray Ionization methods, Tretinoin blood
- Abstract
The effect of the titled tetralone as a retinoic acid metabolism blocking agent (RAMBA) in vivo in comparison with ketoconazole, a well known cytochrome P450 inhibitor, was studied. Development of a HPLC/MS/MS method for the quantification of retinoic acid levels extracted from rat plasma was used to demonstrate that ketoconazole and the tetralone (100 mg/kg) enhanced the endogenous plasma concentration of retinoic acid. Levels of retinoid were raised from a control value of 0.11 to 0.15 and 0.17 ng/mL after treatment with tetralone and ketoconazole respectively showing that the tetralone and ketoconazole lead to comparable effects, indicating an inhibitory activity of the tetralone on retinoic acid metabolism.
- Published
- 2005
- Full Text
- View/download PDF
14. Characterization by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry of the major photoproducts of temoporfin (m-THPC) and bacteriochlorin (m-THPBC).
- Author
-
Angotti M, Maunit B, Muller JF, Bezdetnaya L, and Guillemin F
- Abstract
The photobleaching of 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin (temoporfin, m-THPC) and 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (bacteriochlorin, m-THPBC) was studied in ethanol-water (1 : 99, v/v) and in physiological medium (phosphate-buffered saline, PBS) with or without fetal calf serum (FCS). m-THPC solution was irradiated with the laser radiation of 650 nm, whereas m-THPBC solution underwent two consecutive irradiations at 532 and 650 nm. The photoproducts were characterized by UV-visible absorption spectrophotometry and by matrix-assisted laser desorption/ionization (MALDI) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS). Independent of the solvent used, the phototransformation of either photosensitizer yielded the formation of 5,10,15,20-tetrakis (m-hydroxyphenyl)porphyrin (m-THPP) through a major dehydrogenation process., (Copyright 2001 John Wiley & Sons, Ltd.)
- Published
- 2001
- Full Text
- View/download PDF
15. Free metal ion depletion by "Good's" buffers. II. N-(2-acetamido)-2-aminoethanesulfonic acid (ACESH): complexes with calcium(II), magnesium(II), manganese(II), cobalt(II), zinc(II), nickel(II), and copper(II).
- Author
-
Pope JM, Stevens PR, Angotti MT, and Nakon R
- Subjects
- Calcium, Chelating Agents, Cobalt, Copper, Magnesium, Manganese, Nickel, Potentiometry, Protons, Spectrophotometry, Spectrophotometry, Infrared, Taurine analogs & derivatives, Zinc, Buffers, Cations, Divalent
- Published
- 1980
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.