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2. External stenting and disease progression in saphenous vein grafts two years after coronary artery bypass grafting: A multicenter randomized trial

Author

Benedetto, Umberto, Vohra, Hunaid, Bittar, Mohamad Nidal, Bose, Amal, Berman, Marius, Kharbanda, Rajesh, Paraforos, Alexandros, Ladyshenskij, Leonid, Bonaros, Nikolaos, Schachner, Thomas, Sandner, Sigrid, Angleitner, Philipp, Bolotin, Gil, Jacobs, Stephan, Thielmann, Matthias, Wendt, Daniel, Choi, Yeong-Hoon, Liakopoulos, Oliver, Ohri, Sunil, Lipey, Alexander, Taggart, David P., Gavrilov, Yulia, Krasopoulos, George, Rajakaruna, Cha, Zacharias, Joseph, De Silva, Ravi, Channon, Keith M., Gehrig, Thomas, Donovan, Terrence John, and Friedrich, Ivar

Published
2022
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6. Automated titanium fastener for surgical aortic valve replacement—preventive role for infective endocarditis?

Author

Kahrovic, Amila, Herkner, Harald, Angleitner, Philipp, Werner, Paul, Kocher, Alfred, Ehrlich, Marek, Wiedemann, Dominik, Laufer, Guenther, Simon, Paul, and Andreas, Martin

Subjects
AORTIC valve transplantation, INFECTIVE endocarditis, SUTURING, TITANIUM group, TITANIUM, FASTENERS
Abstract

OBJECTIVES Evidence on long-term clinical outcomes considering suture-securing techniques used for surgical aortic valve replacement is still uncertain. METHODS A total of 1405 patients who underwent surgical aortic valve replacement between January 2016 and December 2022 were included and grouped according to the suture-securing technique used (automated titanium fastener versus hand-tied knots). The occurrence of infective endocarditis during follow-up was set as the primary study end-point. As secondary study end-points, stroke, all-cause mortality and a composite outcome of either infective endocarditis, stroke, or all-cause mortality were assessed. RESULTS The automated titanium fastener was used in 829 (59%) patients, whereas the hand-knot tying technique was used in 576 (41%) patients. The multivariable proportional competing risk regression analysis showed a significantly lower risk of infective endocarditis during follow-up in the automated titanium fastener group (adjusted sub-hazard ratio 0.44, 95% confidence interval 0.20–0.94, P  = 0.035). The automated titanium fastener group was not associated with an increased risk of mortality or attaining the composite outcome, respectively (adjusted hazard ratio 0.81, 95% confidence interval 0.60–1.09, P  = 0.169; adjusted hazard ratio 0.82, 95% confidence interval 0.63–1.07, P  = 0.152). This group was not associated with an increased risk of stroke (adjusted sub-hazard ratio 0.82, 95% confidence interval 0.47–1.45, P  = 0.504). Also, a significantly lower rate of early-onset infective endocarditis was observed in the automated titanium fastener group, (0.4% vs 1.4%, P  = 0.032). CONCLUSIONS Suture-securing with an automated titanium fastener device appears to be superior compared to the hand-knot tying technique in terms of lower risk of infective endocarditis. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Disparities in donor heart acceptance between the USA and Europe: clinical implications

Author

Wayda, Brian, primary, Angleitner, Philipp, additional, Smits, Jacqueline M, additional, van Kins, Arne, additional, Berchtold-Herz, Michael, additional, De Pauw, Michel, additional, Erasmus, Michiel E, additional, Gummert, Jan, additional, Hartyanszky, Istvan, additional, Knezevic, Ivan, additional, Laufer, Guenther, additional, Milicic, Davor, additional, Rega, Filip, additional, Schulze, P Christian, additional, van Caeneghem, Olivier, additional, Khush, Kiran K, additional, and Zuckermann, Andreas O, additional

Published
2023
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15. What about Alkaline Phosphatase in Endocarditis?

Author

Kahrovic, Amila, primary, Poschner, Thomas, additional, Schober, Anna, additional, Angleitner, Philipp, additional, Alajbegovic, Leila, additional, Andreas, Martin, additional, Hutschala, Doris, additional, Brands, Ruud, additional, Laufer, Günther, additional, and Wiedemann, Dominik, additional

Published
2023
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19. Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis.

Author

Kahrovic, Amila, Poschner, Thomas, Schober, Anna, Angleitner, Philipp, Alajbegovic, Leila, Andreas, Martin, Hutschala, Doris, Brands, Ruud, Laufer, Günther, and Wiedemann, Dominik

Subjects
ALKALINE phosphatase, DISEASE risk factors, ENDOCARDITIS, INFECTIVE endocarditis, EXTRACORPOREAL membrane oxygenation
Abstract

(1) Infective endocarditis is a severe inflammatory disease associated with substantial mortality and morbidity. Alkaline phosphatase (AP) levels have been shown to change significantly during sepsis. Additionally, we previously found that a higher initial AP drop after cardiac surgery is associated with unfavorable outcomes. Therefore, the course of AP after surgery for endocarditis is of special interest. (2) A total of 314 patients with active isolated left-sided infective endocarditis at the Department of Cardiac Surgery (Medical University of Vienna, Vienna, Austria) between 2009 and 2018 were enrolled in this retrospective analysis. Blood samples were analyzed at different time points (baseline, postoperative days 1–7, postoperative days 14 and 30). Patients were categorized according to relative alkaline phosphatase drop (≥30% vs. <30%). (3) A higher rate of postoperative renal replacement therapy with or without prior renal replacement therapy (7.4 vs. 21.8%; p = 0.001 and 6.7 vs. 15.6%; p = 0.015, respectively) and extracorporeal membrane oxygenation (2.2 vs. 19.0%; p = 0.000) was observed after a higher initial alkaline phosphatase drop. Short-term (30-day mortality 3.0 vs. 10.6%; p = 0.010) and long-term mortality (p = 0.008) were significantly impaired after a higher initial alkaline phosphatase drop. (4) The higher initial alkaline phosphatase drop was accompanied by impaired short- and long-term outcomes after cardiac surgery for endocarditis. Future risk assessment scores for cardiac surgery should consider alkaline phosphatase. [ABSTRACT FROM AUTHOR]

Published
2023
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20. The effect of occlusive polytetrafluoroethylene outflow graft protectors in left ventricular assist device recipients

Author

Dimitrov, Kamen, primary, Kaider, Alexandra, additional, Granegger, Marcus, additional, Gross, Christoph, additional, Angleitner, Philipp, additional, Wiedemann, Dominik, additional, Riebandt, Julia, additional, Schaefer, Anne-Kristin, additional, Schlöglhofer, Thomas, additional, Laufer, Günther, additional, and Zimpfer, Daniel, additional

Published
2022
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21. External stenting and disease progression in saphenous vein grafts two years after coronary artery bypass grafting: A multicenter randomized trial

Author

Taggart, David P., primary, Gavrilov, Yulia, additional, Krasopoulos, George, additional, Rajakaruna, Cha, additional, Zacharias, Joseph, additional, De Silva, Ravi, additional, Channon, Keith M., additional, Gehrig, Thomas, additional, Donovan, Terrence John, additional, Friedrich, Ivar, additional, Benedetto, Umberto, additional, Vohra, Hunaid, additional, Bittar, Mohamad Nidal, additional, Bose, Amal, additional, Berman, Marius, additional, Kharbanda, Rajesh, additional, Paraforos, Alexandros, additional, Ladyshenskij, Leonid, additional, Bonaros, Nikolaos, additional, Schachner, Thomas, additional, Sandner, Sigrid, additional, Angleitner, Philipp, additional, Bolotin, Gil, additional, Jacobs, Stephan, additional, Thielmann, Matthias, additional, Wendt, Daniel, additional, Choi, Yeong-Hoon, additional, Liakopoulos, Oliver, additional, Ohri, Sunil, additional, and Lipey, Alexander, additional

Published
2022
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26. Response by Andreas et al to Letter Regarding Article, “Increased Thromboembolic Events With Dabigatran Compared With Vitamin K Antagonism in Left Ventricular Assist Device Patients: A Randomized Controlled Pilot Trial”

Author

Andreas, Martin, Moayedifar, Roxana, Wieselthaler, Georg, Wolzt, Michael, Riebandt, Julia, Haberl, Thomas, Angleitner, Philipp, Schlöglhofer, Thomas, Wiedemann, Dominik, Schima, Heinrich, Laufer, Guenther, and Zimpfer, Daniel

Published
2017
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30. Effects of the harvesting technique and external stenting on progression of vein graft disease 2 years after coronary artery bypass

Author

Sandner, Sigrid E, primary, Donovan, Terrence John, additional, Edelstein, Stav, additional, Puskas, John D, additional, Angleitner, Philipp, additional, Krasopoulos, George, additional, Channon, Keith, additional, Gehrig, Thomas, additional, Rajakaruna, Cha, additional, Ladyshenskij, Leonid, additional, De Silva, Ravi, additional, Bonaros, Nikolaos, additional, Bolotin, Gil, additional, Jacobs, Stephan, additional, Thielmann, Matthias, additional, Choi, Yeong-Hoon, additional, Ohri, Sunil, additional, Lipey, Alexander, additional, Friedrich, Ivar, additional, and Taggart, David P, additional

Published
2022
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31. When Nothing Goes Right: Risk Factors and Biomarkers of Right Heart Failure after Left Ventricular Assist Device Implantation

Author

Schlöglhofer, Thomas, primary, Wittmann, Franziska, additional, Paus, Robert, additional, Riebandt, Julia, additional, Schaefer, Anne-Kristin, additional, Angleitner, Philipp, additional, Granegger, Marcus, additional, Aigner, Philipp, additional, Wiedemann, Dominik, additional, Laufer, Günther, additional, Schima, Heinrich, additional, and Zimpfer, Daniel, additional

Published
2022
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33. Incidence, clinical relevance and therapeutic options for outflow graft stenosis in patients with left ventricular assist devices

Author

Dimitrov, Kamen, primary, Kaider, Alexandra, additional, Angleitner, Philipp, additional, Schlöglhofer, Thomas, additional, Gross, Christoph, additional, Beitzke, Dietrich, additional, Granegger, Marcus, additional, Riebandt, Julia, additional, Wiedemann, Dominik, additional, Sandner, Sigrid, additional, Schaefer, Anne-Kristin, additional, Schima, Heinrich, additional, Laufer, Günther, additional, and Zimpfer, Daniel, additional

Published
2021
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34. Pseudothrombocytopenia Inducing Nonindicated Platelet Transfusion after Cardiac Surgery

Author

Ceran, Enise, Schlömmer, Christine, Kröckel, Ivonne, Scheriau, Georg, Angleitner, Philipp, and Steinlechner, Barbara

Subjects
Article Subject
Abstract

Pseudothrombocytopenia (PTCP) is an in vitro phenomenon of low platelet count caused by the agglutination of platelets, leading to false low platelet counts in automated cell counting. Typically, ethylenediaminetetraacetic acid (EDTA) mediates this platelet clumping. PTCP has little clinical significance, but misdiagnosis may lead to unnecessary diagnostic tests and treatment. In this case report, we present a 65-year-old Caucasian female suffering from multiple complications during and after cardiac surgery. During her postoperative stay at the ICU, she was diagnosed with thrombocytopenia and an inadequate response to platelet supplementation.

Published
2021
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35. The adapted Heart Donor Score

Author

Angleitner, Philipp, primary, Kaider, Alexandra, additional, Smits, Jacqueline M., additional, Aliabadi‐Zuckermann, Arezu Z., additional, Osorio‐Jaramillo, Emilio, additional, Laufer, Günther, additional, and Zuckermann, Andreas O., additional

Published
2021
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36. A Standardized Telephone Intervention Algorithm Improves the Survival of Ventricular Assist Device Outpatients

Author

Schlöglhofer, Thomas, Horvat, Johann, Moscato, Francesco, Hartner, Zeno, Necid, Georg, Schwingenschlögl, Harald, Riebandt, Julia, Dimitrov, Kamen, Angleitner, Philipp, Wiedemann, Dominik, Laufer, Günther, Zimpfer, Daniel, and Schima, Heinrich

Subjects
Heart Failure, Male, Main Text Article, Middle Aged, Telephone, —Mechanical circulatory support, Treatment Outcome, Main Text Articles, Surveys and Questionnaires, Outpatients, Ventricular assist device, —Readmission, Humans, Female, —Outpatient management, Heart-Assist Devices, —Algorithm, Propensity Score, Algorithms, Aged, Proportional Hazards Models, Retrospective Studies
Abstract

Ventricular assist devices (VADs) are an established therapeutic option for patients with chronic heart failure. Continuous monitoring of VAD parameters and their adherence to guidelines are crucial to detect problems in an early stage to optimize outcomes. A telephone intervention algorithm for VAD outpatients was developed, clinically implemented and evaluated. During the phone calls, a structured inquiry of pump parameters, alarms, blood pressure, INR, body weight and temperature, exit‐site status and heart failure symptoms was performed and electronically categorized by an algorithm into 5 levels of severity. VAD outpatient outcomes without (n = 71) and with bi‐weekly telephone interviews in their usual care (n = 25) were conducted using proportional hazard Cox regression, with risk adjustment based on a propensity score model computed from demographics and risk factors. From February 2015 through October 2017, 25 patients (n = 3 HeartMate II, n = 4 HeartMate 3 and n = 18 HeartWare HVAD) underwent 637 telephone interventions. In 57.5% of the calls no problems were identified, 3.9% were recalled on the next day because of alarms. In 26.5% (n = 169), the VAD Coordinator had to refer to the physician due to elevated blood pressure (n = 125, >85 mm Hg), INR 4.0 (n = 24) or edema (n = 10), 11.9% of the calls led to a follow‐up because of equipment or exit‐site problems. Propensity‐adjusted 2‐year survival (89% vs. 57%, P = 0.027) was significantly higher for the telephone intervention group. Continuous, standardized communication with VAD outpatients is important for early detection of upcoming problems and leads to significantly improved survival.

Published
2018

39. Incidence, clinical relevance and therapeutic options for outflow graft stenosis in patients with left ventricular assist devices.

Author

Dimitrov, Kamen, Kaider, Alexandra, Angleitner, Philipp, Schlöglhofer, Thomas, Gross, Christoph, Beitzke, Dietrich, Granegger, Marcus, Riebandt, Julia, Wiedemann, Dominik, Sandner, Sigrid, Schaefer, Anne-Kristin, Schima, Heinrich, Laufer, Günther, and Zimpfer, Daniel

Subjects
HEART assist devices, CARDIOGENIC shock, ARTIFICIAL blood circulation, STENOSIS, PROTECTIVE coverings, PROTECTIVE coatings
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES We reviewed our institutional experience with outflow graft stenosis (OGS) in 3 contemporary left ventricular assist devices (LVAD). METHODS Data from 347 consecutive adult recipients of LVAD [Medtronic HVAD (n  = 184, 53.0%), Abbott HeartMate II (n  = 62, 17.9%) and Abbott HeartMate 3 (n  = 101, 29.1%)] implanted between March 2006 and October 2019 were analysed retrospectively. Primary study end points were the incidence of OGS necessitating treatment and survival on LVAD support. RESULTS During the study period, 17 patients (4.9%) developed OGS requiring treatment with a probability of 0.6% at 1 year, 1.9% at 2 years, 3.8% at 3 years, 4.7% at 4 years and 5.9% at 5 years of LVAD support. Notably, in 13.8% of patients, a compression-related narrowing of the outflow graft with a probability of 1.5% at 6 months, 1.8% 1 year, 6.0% at 2 years, 12.3% at 3 years, 15.4% at 4 years and 16.6% at 5 years of LVAD support with no difference between devices (P  = 0.26) was observed. There was a trend towards increased risk of mortality with OGS (hazard ratio 2.21, 95% confidence interval 0.87–5.51; P  = 0.09). OGS preferentially occurred in segments of the outflow graft covered by a protective coating. CONCLUSIONS OGS is a rare but potentially lethal complication during LVAD support. Modifications of pump design and implant techniques may be needed because OGS preferentially occurs within covered portions of the outflow graft. Systematic screening may be warranted. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Thrombolysis as first-line therapy for Medtronic/HeartWare HVAD left ventricular assist device thrombosis

Author

Dimitrov, Kamen, primary, Maier, Julian, additional, Sandner, Sigrid, additional, Riebandt, Julia, additional, Wiedemann, Dominik, additional, Moayedifar, Roxana, additional, Schlöglhofer, Thomas, additional, Angleitner, Philipp, additional, Niederdöckl, Jan, additional, Schima, Heinrich, additional, Tschernko, Edda, additional, Laufer, Guenther, additional, and Zimpfer, Daniel, additional

Published
2020
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42. Molecular‐level HLA mismatch is associated with rejection and worsened graft survival in heart transplant recipients – a retrospective study

Author

Osorio‐Jaramillo, Emilio, primary, Haasnoot, Geert W., additional, Kaider, Alexandra, additional, Schaefer, Anne‐Kristin, additional, Haberl, Thomas, additional, Goekler, Johannes, additional, Angleitner, Philipp, additional, Moayedifar, Roxana, additional, Zuckermann, Andreas, additional, Fischer, Gottfried F., additional, Laufer, Guenther, additional, Claas, Frans H. J., additional, and Aliabadi‐Zuckermann, Arezu Z., additional

Published
2020
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44. Less Invasive Left Ventricular Assist Device Implantation Is Safe and Reduces Intraoperative Blood Product Use: A Propensity Score Analysis VAD Implantation Techniques and Blood Product Use

Author

Riebandt, Julia, primary, Schlöglhofer, Thomas, additional, Moayedifar, Roxana, additional, Wiedemann, Dominik, additional, Wittmann, Franziska, additional, Angleitner, Philipp, additional, Dimitrov, Kamen, additional, Tschernko, Edda, additional, Laufer, Günther, additional, and Zimpfer, Daniel, additional

Published
2020
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45. Left ventricular assist device driveline infections in three contemporary devices.

Author

Schlöglhofer, Thomas, Michalovics, Peter, Riebandt, Julia, Angleitner, Philipp, Stoiber, Martin, Laufer, Günther, Schima, Heinrich, Wiedemann, Dominik, Zimpfer, Daniel, and Moscato, Francesco

Subjects
HEART assist devices, PATIENT readmissions, HOSPITAL admission & discharge, C-reactive protein
Abstract

Driveline infections (DLI) are common adverse events in left ventricular assist devices (LVADs), leading to severe complications and readmissions. The study aims to characterize risk factors for DLI readmission 2 years postimplant. This single‐center study included 183 LVAD patients (43 HeartMate II [HMII], 29 HeartMate 3 [HM3], 111 HVAD) following hospital discharge between 2013 and 2017. Demographics, clinical parameters, and outcomes were retrospectively analyzed and 12.6% of patients were readmitted for DLI, 14.8% experienced DLI but were treated in the outpatient setting, and 72.7% had no DLI. Mean C‐reactive protein (CRP), leukocytes and fibrinogen were higher in patients with DLI readmission (P <.02) than in outpatient DLI and patients without DLI, as early as 60 days before readmission. Freedom from DLI readmission was comparable for HMII and HVAD (98% vs. 87%; HR, 4.52; 95% CI, 0.58‐35.02; P =.15) but significantly lower for HM3 (72%; HR, 10.82; 95% CI, 1.26‐92.68; P =.03). DLI (HR, 1.001; 95% CI, 0.999‐1.002; P =.16) or device type had no effect on mortality. DLI readmission remains a serious problem following LVAD implantation, where CRP, leukocytes, and fibrinogen might serve as risk factors already 60 days before. HM3 patients had a higher risk for DLI readmissions compared to HVAD or HMII, possibly because of device‐specific driveline differences. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Diminished impact of cytomegalovirus infection on graft vasculopathy development in the antiviral prophylaxis era - a retrospective study

Author

Goekler, Johannes, primary, Zuckermann, Andreas, additional, Kaider, Alexandra, additional, Angleitner, Philipp, additional, Osorio-Jaramillo, Emilio, additional, Moayedifar, Roxana, additional, Uyanik-Uenal, Keziban, additional, Kainz, Frieda-Marie, additional, Masetti, Marco, additional, Laufer, Guenther, additional, and Aliabadi-Zuckermann, Arezu Z., additional

Published
2018
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