1. Facilitated Long Chain Fatty Acid Uptake by Adipocytes Remains Upregulated Relative to BMI for More Than a Year After Major Bariatric Surgical Weight Loss*
- Author
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Ge, Fengxia, Walewski, José L, Torghabeh, Mehyar Hefazi, Lobdell, Harrison, Hu, Chunguang, Zhou, Shengli, Dakin, Greg, Pomp, Alfons, Bessler, Marc, Schrope, Beth, Ude-Welcome, Aku, Inabnet, William B, Feng, Tianshu, Carras-Terzian, Elektra, Anglade, Dieunine, Ebel, Faith E., and Berk, Paul D.
- Subjects
Adult ,Male ,obesity ,bariatric surgery ,adipocytes ,Fatty Acids ,Subcutaneous Fat ,Middle Aged ,Article ,fatty acid uptake ,Body Mass Index ,Up-Regulation ,spexin ,Gastrectomy ,Weight Loss ,Humans ,Female ,Omentum ,Follow-Up Studies - Abstract
This study examined whether changes in adipocyte long chain fatty acid (LCFA) uptake kinetics explain the weight regain increasingly observed following bariatric surgery.Three groups (10 patients each) were studied: patients without obesity (NO: BMI 24.2 ± 2.3 kg m(-2) ); patients with obesity (O: BMI 49.8 ± 11.9); and patients classified as super-obese (SO: BMI 62.6 ± 2.8). NO patients underwent omental and subcutaneous fat biopsies during clinically indicated abdominal surgeries; O were biopsied during bariatric surgery, and SO during both a sleeve gastrectomy and at another bariatric operation 16 ± 2 months later, after losing 113 ± 13 lbs. Adipocyte sizes and [(3) H]-LCFA uptake kinetics were determined in all biopsies.Vmax for facilitated LCFA uptake by omental adipocytes increased exponentially from 5.1 ± 0.95 to 21.3 ± 3.20 to 68.7 ± 9.45 pmol/sec/50,000 cells in NO, O, and SO patients, respectively, correlating with BMI (r = 0.99, P0.001). Subcutaneous results were virtually identical. By the second operation, the mean BMI (SO patients) fell significantly (P0.01) to 44.4 ± 2.4 kg m(-2) , similar to the O group. However, Vmax (40.6 ± 11.5) in this weight-reduced group remained ~2X that predicted from the BMI:Vmax regression among NO, O, and SO patients.Facilitated adipocyte LCFA uptake remains significantly upregulated ≥1 year after bariatric surgery, possibly contributing to weight regain.
- Published
- 2015