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Formation of claudin-10 based tight junctions (TJs) is paramount to paracellular Na+ transport in multiple epithelia. Sequence variants in CLDN10 have been linked to HELIX syndrome, a salt-losing tubulopathy with altered handling of divalent cations accompanied by dysfunctional salivary, sweat, and lacrimal glands. Here, we investigate molecular basis and phenotypic consequences of a newly identified homozygous CLDN10 variant that translates into a single amino acid substitution within the fourth transmembrane helix of claudin-10. In addition to hypohidrosis (H), electrolyte (E) imbalance with impaired urine concentrating ability, and hypolacrimia (L), phenotypic findings include altered salivary electrolyte composition and amelogenesis imperfecta but neither ichthyosis (I) nor xerostomia (X). Employing cellular TJ reconstitution assays, we demonstrate perturbation of cis- and trans-interactions between mutant claudin-10 proteins. Ultrastructures of reconstituted TJ strands show disturbed continuity and reduced abundance in the mutant case. Throughout, both major isoforms, claudin-10a and claudin-10b, are differentially affected with claudin-10b showing more severe molecular alterations. However, expression of the mutant in renal epithelial cells with endogenous TJs results in wild-type-like ion selectivity and conductivity, indicating that aberrant claudin-10 is generally capable of forming functional paracellular channels. Thus, mutant proteins prove pathogenic by compromising claudin-10 TJ strand assembly. Additional ex vivo investigations indicate their insertion into TJs to occur in a tissue-specific manner.

Background Information on the prevalence of temporomandibular disorders (TMD) or possible/probable bruxism in seniors is heterogeneous and sparse. Objectives To elucidate the prevalence of TMD and possible/probable bruxism in German adults aged 60 years and older. Methods Participants of the Interdisciplinary Longitudinal Study of Adult Development and Aging (ILSE) born between 1950–1952 (C1) and 1930–1932 (C2) were examined in 2014–2016 (fourth wave). The participants were surveyed and clinically examined by one calibrated examiner. Two questions of the Patient Health Questionnaire (PHQ) were utilised to evaluate self-reported bruxism. The clinical examination included signs of probable bruxism and the RDC/TMD examination protocol. Results Data from 191 participants were available. No RDC/TMD diagnosis was made in 83.2%. Of the participants, 15.2% received a single diagnosis and 1.6% multiple diagnoses that included disc displacements (9.4%) and degenerative joint diseases (8.9%). A total of 24.7% reported bruxism that included self-reported awake bruxism in 11.9% and sleep bruxism in 16.2%. Wear was clinically identified in 27.2% of the participants. No sex-related differences were observed. Significant differences were detected for probable bruxism between C1 (14.1%) and C2 (54.3%). Conclusion In the German population aged 60 years and older, the prevalence of TMD is 16.8%. TMD is characterised by temporomandibular joint disorders, including disc displacements and degenerative joint disorders. Bruxism was observed in a quarter of the old population.

This study evaluated the pull-off force between titanium abutments and zirconia crowns that were bonded using four different cements and two abutment heights (AHs). In total, 24 titanium abutments (3-mm AH: n = 12; 5-mm AH: n = 12; taper: 7.5 degrees) and 24 zirconia crowns were designed, manufactured, cemented with one of four dental cements (one temporary, two semi-permanent, one permanent), stored in water for 24 hours, and thermocycled (37,500 cycles, equal to ~4 years in vivo). The pull-off force needed to separate the abutment and crown in each combination was determined eight times per combination of cement type and abutment height. Statistical analysis was conducted at a significance level of P.05. The permanent self-adhesive composite cement showed a high pull-off force with a risk for crown fracture (mean: 381 N for 3-mm AH; 617 N for 5-mm AH). In contrast, the temporary zinc-oxide cement showed frequent premature decementation after thermocycling (mean: 14 N with 3-mm AH; 28 N with 5-mm AH). Both semi-permanent methacrylate-based cements ranked between the other cements (mean: 31 N/37 N for 3-mm AH; 120 N/72 N for 5-mm AH). Statistically significant differences were found between all cements (ANOVA P.001). The abutment heights differed significantly for all cements (P.005) except for the temporary zinc-oxide cement. Methacrylate-based cements were the most reliable cements for semi-permanent mounting of zirconia crowns on titanium abutments. They provide sufficient retention to avoid unintended loosening and are weak enough to remove the crown without causing damage.

To survey the materials favored by dentists for intraoral repair of cohesive chipping.From August 2019 to February 2020, dentists were surveyed to determine the frequency of cohesive chipping experienced within the last 3 months and to identify their preferred approaches for intraoral repair.Of the participants, 42.5% observed chipping (n = 506). Participants favored the application of roughening devices, silane, and composite resins. Self-etching glass-ceramic primers or hydrofluoric acid were used for ceramic etching.Dentists apply a variety of materials for intraoral repair of chipping, including materials that are not approved for intraoral use.

Zusammenfassung Hintergrund Kraniomandibuläre Dysfunktionen (CMD) können auch im hohen Alter auftreten. Die Prävalenz von CMD-Symptomen bei Senioren wurde bisher nur wenig untersucht. Ziel der Arbeit Ziel dieser Untersuchung war es, die Prävalenz von Symptomen einer CMD bei Senioren nach Befunderhebung mit den Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) zu bestimmen. Dabei sollten die Prävalenzwerte von jüngeren (60 bis 74 Jahren) und älteren (≥ 75 Jahre) Senioren verglichen werden. Material und Methoden Im Rahmen der Interdisziplinären Längsschnittstudie des Erwachsenenalters (ILSE) wurden Probanden nach repräsentativen Gesichtspunkten rekrutiert. Während der vierten Nachverfolgungswelle im Zeitraum von 2014 bis 2016 im Bereich des Studienzentrums Leipzig wurden die Probanden auf das Vorliegen von anamnestischen und klinischen CMD-Symptomen untersucht. Ergebnisse Anamnestische CMD-Symptome bei Senioren (n = 192) waren v. a. durch Schmerzen im Gesichtsbereich (13,0 %) gekennzeichnet. Das häufigste klinische CMD-Symptom waren Kiefergelenkgeräusche mit einer Prävalenz bis zu 35,5 %. Frauen gaben anamnestisch häufiger Kopfschmerzen/Migräne an. Kiefergelenkgeräusche und eine limitierte Mundöffnung wurden klinisch häufiger bei weiblichen Teilnehmenden beobachtet. Statistisch signifikante Unterschiede zeigten sich bei dem Vergleich von jüngeren und älteren Senioren hinsichtlich der Prävalenz von Kopfschmerzen/Migräne, jedoch nicht bei klinischen Symptomen. Schlussfolgerung Anamnestisch werden Gesichtsschmerzen von 13,0 % der Senioren angegeben. Kiefergelenkgeräusche werden bei jedem dritten Älteren klinisch beobachtet. CMD-Symptome scheinen bei jüngeren und älteren Senioren im ähnlichen Maße ausgeprägt zu sein.

Objectives The objective was to describe the physical and psychosocial features of patients attending a specialized consultation hour for temporomandibular disorders (TMD). This investigation focused on those patients who did not receive a diagnosis according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Materials and methods From 2004 to 2017, patients seeking care during a TMD-specialized consultation hour were consecutively recruited. Each patient completed a TMD-related questionnaire, psychosocial questionnaires (Graded Chronic Pain Scale, Hospital Anxiety and Depression Scale, Beschwerden-Liste), and the Oral Health Impact Profile-49. The clinical examination was performed according to the RDC/TMD. Results The mean age of the 1020 patients was 43.3 years (75.3% female). According to the RDC/TMD decision trees, 351 patients were categorized without a TMD diagnosis (NoTMDdx). The most frequent reasons for seeking care were orofacial pain/TMJ pain or headaches revealing an OR of 1.89 (for TMDdx group). A relevant proportion of patients was categorized as positive for anxiety (NoTMDdx/TMDdx 30.8/41.2%; p = 0.072), depression (20.8/23.9%; p = 0.433), non-specific physical symptoms (31.4/44.1%; p < 0.001), or dysfunctional chronic pain (11.5/18.2%; p < 0.001). In both patient groups, the oral health-related quality of life was impaired (42.9/52.7 points; p < 0.001), and the frequency of therapy measures prior to the consultation hour was high. Conclusions Patients seeking care from TMD specialists were usually referred with TMD-associated symptoms. Of those, a relevant proportion did not receive a diagnosis according to RDC/TMD decision trees. Clinical relevance Psychosocial screening and the avoidance of overtreatment are recommended for patients with TMD-related symptoms.

Purpose To investigate the effect of monolithic zirconia-based occlusal surfaces on signs and symptoms of temporomandibular disorders (TMD) after short-term clinical service. Materials and methods Patients were supplied with multi-unit fixed dental prostheses (FDP) featuring monolithic zirconia-based occlusal surfaces. Prior to prosthetic treatment and 1 year after insertion anamnestic facial pain, pain with palpation of muscles/joints and joint sounds were examined. Results Of the 50 patients, 43 were re-examined after 1 year. Perceived facial pain was not present, pain with palpation occurred in 2 patients, and TMJ sounds decreased; differences were not statistically significant (P ≥ .058). Conclusion Single tooth-supported multiunit FDPs featuring monolithic zirconia-based occlusal surfaces did not affect TMD-associated signs and symptoms.

Aim Verification of the interrater reliability of axis I diagnoses of the German version of the DC/TMD. The hypothesis was that the DC/TMD protocol yields comparable results, if examiner instructions are closely followed. Material and methods A culturally equivalent German translation of the DC/TMD was developed. During a 1-day calibration workshop at the University of Heidelberg, three examiners were trained by the DC/TMD Training and Calibration Center. According to the calibration guidelines, 16 models (11 cases, five non-cases) were examined by four experienced TMD specialists. Reliability was calculated with reference to the reference standard examiner as percentage agreement and kappa coefficients for DC/TMD diagnoses and intraclass correlation coefficients (ICCs) for findings. Results Excellent reliability was achieved for the diagnoses myalgia, myofascial pain with referral, arthralgia, headache attributed to TMD, disc displacement (DD) with reduction, DD without reduction without limited opening (κ = 0.85…1.00). Degenerative joint disease was diagnosed with substantial agreement (κ = 0.64), DD with reduction with intermittent locking and DD without reduction with limited opening were not present in our sample. Overall percentage agreement was 94%-100% for all diagnoses. Conclusion The German version of the DC/TMD shows very good reliability and can be recommended for the use in clinical and research settings.

Die wahrgenommene Mundgesundheit und damit verbundene Beeintrachtigungen (mundgesundheitsbezogene Lebensqualitat, MLQ) sind ein entscheidender motivationaler Faktor fur Patienten, die Zahnarztin/den Zahnarzt zu therapeutischen Zwecken aufzusuchen. Allerdings erfolgt die Erfassung in der Regel unsystematisch und unvollstandig. Durch eine systematische Erhebung wird es moglich, die durch den Patienten empfundenen Mundgesundheitsprobleme schnell und umfassend zu bestimmen, was v. a. vor prothetischen Neuversorgungen wichtig ist. Daruber hinaus eroffnet es die Moglichkeit, die individuellen Effekte von zahnarztlichen Interventionen messbar und damit therapieubergreifend vergleichbar zu machen. Mit dem Oral Health Impact Profile gibt es ein den eigenen Bedurfnissen gut adaptierbares, frei verfugbares Instrument. Hierdurch ist belegt, dass Patienten mit verkurzter Zahnreihe keine subjektive Verbesserung ihrer MLQ bei Ersatz der Seitenzahne erfahren, wenn sie diese nicht vermissen. Auch ist mittlerweile belegt, dass Patienten, welche mit ihren Totalprothesen zufrieden sind, bei Unterstutzung ihrer Prothesen mittels Implantaten keine erhebliche Verbesserung ihrer Mundgesundheitssituation empfinden.

Objectives This study aimed to survey dentists in Germany to identify their favored materials for the fabrication of tooth-supported single crowns (SCs) depending on the location of the abutment teeth and the preparation margin. Materials and methods The survey included questions regarding demographic characteristics of dentists/their dental practice and preferred restorative materials for the fabrication of SCs for abutment teeth 16, 11, 34, and 36 with either supra- or subgingival preparation margins. Results Between August 2019 and February 2020, 721 dentists participated in the survey; responses from 33 dentists were excluded from data analysis because the dentists did not work in Germany or provided less than one fixed dental prosthesis/month. Dentists favored ceramic materials independent of the location of the abutment tooth and preparation margin (56.6–92.2%). CAD/CAM resin composites or full metals were preferred by only a few participants. A significantly higher proportion of dentists recommended porcelain fused to metal for subgingival preparation margins than for supragingival margins (p Conclusions Dentists in Germany selected restorative materials for SCs depending on the clinical scenario. Since numerous dentists did not specify the ceramic materials, postgraduate information and education might help to extend expertise. Clinical relevance The results of this survey provide insight into the favored materials of dentists for the fabrication of tooth-supported SCs.

To investigate the impact of the occlusal contact situation and occlusal adjustment on wear, roughness, and fracture force of molar crowns.CAD/CAM crowns (lower right first molar, n = 64; 4 groups à 8, 3Y-TZP zirconia and resin composite) and corresponding antagonists (upper right first molar; 3Y-TZP zirconia) were manufactured. Crowns were constructed according to two principles of occlusion (group "T": Peter K. Thomas' "point-centric" cusp-to-fossa tripodization concept, with 15 contact points; group "RA" Sigurd P. Ramfjord and Major M. Ash, "freedom in centric" concept with four contacts). On one half of the crowns, occlusal adjustment was performed (groups "T adjusted" and "RA adjusted"). All crowns underwent combined thermal cycling (TC) and mechanical loading (ML) (ML: 1.2 × 10The resin composite crowns yielded significantly higher mean values for wear area and depth (p 0.001) and lower fracture forces (p 0.001). Resin composite surfaces showed increased roughness after TCML while zirconia exhibited smoothened surfaces. The occlusal design significantly impacted wear depth (p = 0.012) and fracture force (p 0.001). Resin composite crowns with fewer contact points (group RA) showed more wear and lower fracture force. Adjusted resin composite crowns showed increased wear areas and depths (p = 0.009-0.013). For zirconia crowns, the adjustment impacted wear area (p = 0.013), wear depth (p = 0.008), and fracture force (p = 0.006), with adjusted zirconia crowns exhibiting more wear and lower maximum forces until fracture. Zirconia wear depth was also impacted by the occlusal design (p = 0.012). Antagonistic wear was influenced by the restorative material, the occlusal contact pattern, and the adjustment.The investigated materials show strongly varying performances with zirconia being significantly influenced by the adjustment, while for resin composites, contact design and adjustment had a major impact.The results show the necessity of adapting occlusal design and adjustment in order to improve roughness, wear, and stability of zirconia and resin composite crowns.

The journal of evidence based dental practice 23(1S), 101794 (2023). doi:10.1016/j.jebdp.2022.101794 special issue: "Dental patient-reported outcomes 2022 Dental PROs / Edited by Fang Hua", Published by Elsevier, Amsterdam [u.a.]

BACKGROUND Prevalence values for symptoms and signs of temporomandibular disorders (TMD) in adolescents vary within the literature due to differences in set-ups of examination protocols. OBJECTIVES The objective was to present prevalence values for symptoms and signs of TMD in German adolescents that were observed within a standardised examination. Prevalence values comparing gender or pubertal status should be investigated. METHODS A cross-sectional sample of the LIFE Child Study aged 10 to 18 was examined. A questionnaire gathering anamnestic symptoms of TMD was completed, and an examination according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) was performed by trained dentists. Pubertal status according to Tanner stages was documented. Descriptive statistics, Mann-Whitney U and Wilcoxon signed-rank tests were performed. RESULTS A total of 1.116 participants (mean age 12.9 years, 51.4% female) were consecutively recruited. Most prevalent anamnestic symptoms were headaches (55.7%) and temporomandibular joint (TMJ) sounds (17.6%). The major clinical sign was TMJ sounds (31.9%). Both the examination of muscles or TMJs showed that pain to palpation was statistically significantly higher than familiar pain (P

The aim of this study was to analyse the impact of different clinical conditioning approaches and an ammonium polyfluoride- and trimethoxysilylpropyl methacrylate-based experimental primer for intraoral luting of buccal tubes on silica-based ceramic surfaces. A total of 60 leucite-reinforced glass ceramic molar crowns were conditioned using different methods (n = 10): I-roughening, hydrofluoric acid, silane; II-roughening, silane; III-roughening, experimental coupling agent; IV-experimental coupling agent; V-roughening; VI-no treatment. A buccal tube was adhesively luted to the ceramic surface. Subsequently, water storage, thermocycling and chewing simulation were carried out. The shear bond strength (SBS) was determined, and changes in the surface were assessed. All tubes of the control group (group VI) debonded after incubation. The conditioning methods using coupling agents revealed mean values for SBS of 61.56 MPa (group I), 45.53 MPa (group III), 41.65 MPa (group II), and 23.14 MPa (group IV). In groups I–III, both composite residues and cracks/tear-outs were detected. The conditioning of silicate ceramic surfaces with a suitable coupling agent system appears to allow sufficient adhesive luting of buccal tubes. The intraoral luting of fixed appliance elements on silicate ceramic surfaces using an ammonium polyfluoride- and trimethoxysilylpropyl methacrylate-based ceramic primer can withstand orthodontic forces. Ammonium polyfluoride- and trimethoxysilylpropyl methacrylate-based ceramic primers revealed promising results for the intraoral adhesive luting of orthodontic devices to silica-based ceramic crowns.

The discoloration of enamel and dentin often has a lasting negative impact on the esthetic appearance. The current clinical case report illustrates which results can be achieved by supplying a patient with restorations fabricated from translucent tooth-colored materials for a traumatically damaged and discolored anterior tooth. A 20-year-old patient sought dental care due to a severe discrepancy in color and shape of tooth 11. As internal bleaching did not reveal a satisfying esthetic outcome, consequently we decided to supply the tooth with a 360° veneer. For material comparisons, the restorations were fabricated from five different monolithic materials. The preparation was performed following the guidelines for 360° veneers, featuring a circular thickness of 0.9 mm. The selected materials included indirect resin composite (Grandio blocs LT, VOCO), feldspathic ceramic (VITABLOCS Mark II LT, VITA Zahnfabrik), leucite-reinforced glass ceramic (IPS Empress CAD LT, Ivoclar Vivadent), lithium disilicate ceramic (IPS e.max CAD LT, Ivoclar Vivadent), and zirconia with 5 mol% yttrium oxide (VITA YZ XT Multicolor LT, VITA Zahnfabrik). The materials were compared for the parameters profitability, esthetics, and patient satisfaction. With a thin layer thickness (0.8-0.9 mm circular), the tooth discoloration could not be adequately covered by any of the 360° veneers. After more extensive preparation, providing a circular thickness of the restoration up to 1.5 mm, all five monolithic materials as well as an additional individually veneered zirconium dioxide crown, serving as a reference, could achieve a satisfactory result. However, the overall esthetic appearance was completely rounded off by the individualized zirconium dioxide crown.

When consumed in excess, acidic foods and beverages can cause dental erosions leading to irreversible loss of tooth substance. In many cases, prosthetic rehabilitation of the damaged teeth is mandatory. The aim of this in vitro study was to investigate, for the first time on this scale, the resistance of various commonly used self-adhesive resin luting cements (Bifix SE, VOCO; G-Cem LinkAce, GC; RelyX Unicem, 3 M Oral Care; SpeedCEM Plus, Ivoclar ) against acidic media, and to find out whether they can withstand long-term exposure. These results were compared with an adhesive resin luting cement (Panavia V5, Kuraray) that functioned as reference gold standard. Furthermore we applied area roughness parameters for surface texture analysis in the present investigation, to highlight their advantages for investigations on the surface quality of resin luting cements.Six specimens with identical diameter (10 mm) and thickness (3 mm) were prepared from each self-adhesive and adhesive resin luting cement and forwarded to an incubation in various acidic media for a period of 232 h. Conductivity and pH-values of each acidic medium was analyzed for each material group prior (t 0) and after exposure (t 1). The specimens were examined for Vickers microhardness and surface quality. For the evaluation of surface roughness, the parameters Sa, Sdr, Spc Spk, Sk, and Svk were investigated by using different filtered surfaces (S-L; S-F) according to ISO 25 178. Statistical analysis was conducted at a significance level of α = 0.050.For the evaluation of the acid resistance of self-adhesive resin luting cements investigations on conductivity and pH-value assessment of storage solution appear unsuitable, while the assessment of microhardness and surface analysis revealed valid data. It could be shown that changes in surface texture of the resin luting cements can be determinend in qualitative and quantitative manner. While the microhardness and surface quality of some resin luting cements hardly changed, others showed significantly reduced values in microhardness and changes in their surface quality (p 0.001).The data of the current study emphasize the relevance of interactions between resin luting cements and acids and suggest further laboratory and clinical studies to elucidate its impact on the clinical performance of the materials investigated.

PURPOSE To investigate changes in oral health prior to and after conversion of fractured abutment teeth in double crown-retained removable dental protheses (DC-RDPs) into root-anchored ball attachments. MATERIALS AND METHODS Twenty patients were supplied with one root-anchored ball attachment after abutment tooth fracture. The Oral Health Impact Profile (OHIP-49) was completed by the patients prior to and after treatment to assess changes in perceived oral health. RESULTS Changes in OHIP were statistically and clinically significant (28.90 points prior to treatment and 13.80 points after treatment), especially in cases with a minor number of remaining double crowns. CONCLUSION The conversion of fractured abutment teeth in DC-RDPs into root-anchored ball attachments can be an effective strategy for improving perceived oral health.

Background A shortened dental arch (SDA) is an established treatment concept for patients with missing molars. However, little is known regarding long-term course of oral health-related quality of life (OHRQoL) in patients with SDA and the benefits from replacement of missing molars. Aim Purpose of this multi-center randomized clinical trial was to assess OHRQoL over a period of 15 years in patients with molar replacement by a removable partial denture (RPD) compared to patients with a restored SDA without molar replacement. Design Patients at least 35 years of age with all molars missing in one jaw and at least the canine and one premolar present on each side were included. Patients received either a precision attachment-retained, RPD for replacement of missing molars (N=79), or the dental arch ended with the second premolar (SDA) that had to be present or replaced by a cantilever fixed dental prosthesis (N=71). Follow-up examinations continued for 15 years. OHRQoL was assessed with the 49-item Oral Health Impact Profile (OHIP). OHIP summary and dimension scores were longitudinally modeled in the statistical analyses to assess course of OHRQoL over time applying an intention-to-treat approach. In addition, scores for the OHRQoL dimensions Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact were analyzed. Results After an initial improvement in OHRQoL indicated by a mean decrease of 20.0 OHIP points with an effect size of 0.61 in the entire study population, OHRQoL stayed relatively constant over the entire follow-up period. Assuming a constant time and treatment effects over the study period, OHRQoL did not differ statistically significant between the two treatments (0.4 OHIP points; 95%-CI: −7.1 to 6.2). OHRQoL after treatment did not change notably over 15 years and was statistically nonsignificant as well (p=0.872). Similar findings were observed in all four OHRQoL dimensions. Conclusions In patients, missing all molars in one jaw OHRQoL improved providing RPD or restoring SDA to a clinically relevant degree. Treatment-related improvement remained mostly stable over a period of at least 15 years. Therefore, patients can be informed that both treatment concepts are equivalent concerning long-term OHRQoL. Accordingly, patients’ preferences regarding treatment options should be granted priority in treatment decision making with the SDA treatment option being the default.

Objectives: The aim of this systematic review was to provide an overview of the scientific evidence available from prospective clinical studies regarding denture hygiene interventions. Therefore, investigations addressing the efficacy of removing microorganisms and biofilms formed on the surface of removable dental prostheses (RDPs) and denture base materials in situ and their impact on the properties of denture base materials, such as color stability, surface roughness, and dimensional stability, were included. Basic procedures: A systematic literature search was conducted from June 1975 to May 2020 and included articles published in English that have been indexed in the digital archives of PubMed and Cochrane (including PubMed, Embase, ICTRP, CT.gov). A complementary manual search of the initially retrieved studies was conducted. Inclusion criteria comprised prospective clinical trials with a minimum of ten participants investigating (1) approaches and methods to remove biofilms formed on the surface of RDPs and denture base materials in situ and/or (2) the influence of these biofilms on denture base materials. A total of forty-four studies were included in this systematic review, which was registered in the PROSPERO database (CRD42020189649). Findings and conclusions: Data gathered from the systematic review indicate that the combined use of chemical and mechanical denture hygiene interventions is significantly more effective than single cleaning approaches. Only limited evidence is available from clinical studies regarding the effect of denture hygiene interventions on the properties of denture base materials.

Compared to thermoplastic manufacturing techniques, computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies make it easier to process modern restorative and prosthetic materials with improved material properties. In dentistry, tooth-colored alternatives to metal-based frameworks for application in removable dental prostheses (RDP) emerged. With regard to this aspect, the current article provides an overview of the specific material properties of polyoxymethylene (POM). Furthermore, it reviews scientific literature indexed in PubMed and Web of Science that focuses on RDPs fabricated from POM within the last 10 years. Finally, a prosthetic rehabilitation of a patient with a RDP fabricated from POM is illustrated and observations during a follow-up over 10 months are described. Scientific data and clinical observations indicate that polyoxymethylene is a promising material that bridges gaps in dental therapeutic options. While survival time may be limited due to wear, POM might be a favorable option for application in semi-permanent restorations.

To investigate the effect of monolithic zirconia-based occlusal surfaces on signs and symptoms of temporomandibular disorders (TMD) after short-term clinical service.Patients were supplied with multi-unit fixed dental prostheses (FDP) featuring monolithic zirconia-based occlusal surfaces. Prior to prosthetic treatment and 1 year after insertion anamnestic facial pain, pain with palpation of muscles/joints and joint sounds were examined.Of the 50 patients, 43 were re-examined after 1 year. Perceived facial pain was not present, pain with palpation occurred in 2 patients, and TMJ sounds decreased; differences were not statistically significant (P ≥ .058).Single tooth-supported multiunit FDPs featuring monolithic zirconia-based occlusal surfaces did not affect TMD-associated signs and symptoms.

Journal of oral rehabilitation 48(6), 738-744 (2021). doi:10.1111/joor.13167, Published by Wiley-Blackwell, Oxford [u.a.]

Temporomandibular disorders (TMD) are common in the general population even in old age. Information on the prevalence of TMD in older people is sparse.To present prevalence values for symptoms and signs of TMD in old people according to the research diagnostic criteria for temporomandibular disorders (RDC/TMD). To compare prevalence values between the age groups of 60-74 years (younger seniors) and ≥ 75 years (older seniors).Subjects of the interdisciplinary longitudinal study of adult development (ILSE), a representative sample of old people in Germany, were examined between 2014-2016. Subjects of the urban area of Leipzig were chosen to examine symptoms and signs of TMD.The most prevalent symptom was orofacial pain (13.0%) in the aged participants (n = 192). Temporomandibular joint (TMJ) sounds were the most prevalent sign with values up to 35.5%. Gender comparisons revealed higher prevalence values for the symptom headache/migraine as well as for the signs TMJ sounds (especially clicking sounds) and limited mouth opening in females. Regarding age groups, significant differences were only observed for self-reported headache/migraine.Orofacial pain was reported by 13.0% of the subjects and TMJ sounds were observed in every third participant. Similar prevalence values for TMD symptoms and signs in younger and older seniors were found.HINTERGRUND: Kraniomandibuläre Dysfunktionen (CMD) können auch im hohen Alter auftreten. Die Prävalenz von CMD-Symptomen bei Senioren wurde bisher nur wenig untersucht.Ziel dieser Untersuchung war es, die Prävalenz von Symptomen einer CMD bei Senioren nach Befunderhebung mit den Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) zu bestimmen. Dabei sollten die Prävalenzwerte von jüngeren (60 bis 74 Jahren) und älteren (≥ 75 Jahre) Senioren verglichen werden.Im Rahmen der Interdisziplinären Längsschnittstudie des Erwachsenenalters (ILSE) wurden Probanden nach repräsentativen Gesichtspunkten rekrutiert. Während der vierten Nachverfolgungswelle im Zeitraum von 2014 bis 2016 im Bereich des Studienzentrums Leipzig wurden die Probanden auf das Vorliegen von anamnestischen und klinischen CMD-Symptomen untersucht.Anamnestische CMD-Symptome bei Senioren (n = 192) waren v. a. durch Schmerzen im Gesichtsbereich (13,0 %) gekennzeichnet. Das häufigste klinische CMD-Symptom waren Kiefergelenkgeräusche mit einer Prävalenz bis zu 35,5 %. Frauen gaben anamnestisch häufiger Kopfschmerzen/Migräne an. Kiefergelenkgeräusche und eine limitierte Mundöffnung wurden klinisch häufiger bei weiblichen Teilnehmenden beobachtet. Statistisch signifikante Unterschiede zeigten sich bei dem Vergleich von jüngeren und älteren Senioren hinsichtlich der Prävalenz von Kopfschmerzen/Migräne, jedoch nicht bei klinischen Symptomen.Anamnestisch werden Gesichtsschmerzen von 13,0 % der Senioren angegeben. Kiefergelenkgeräusche werden bei jedem dritten Älteren klinisch beobachtet. CMD-Symptome scheinen bei jüngeren und älteren Senioren im ähnlichen Maße ausgeprägt zu sein.

Purpose: To survey dentists in Germany regarding their preferred cementation regimen for fixed dental prostheses (FDPs) fabricated from various restorative materials. Materials and Methods: An online survey was developed for completion by dentists in Germany between 08/2019 and 02/2020. The questionnaire gathered information about the cementation regimen (conventional, including the acid-base cements zinc-oxide phosphate or any glass-ionomer cement; self-adhesive; adhesive; don’t know) that the participant would preferably select for the insertion of single- or multi-unit FDPs fabricated from various restorative materials. Data were also collected on demographic and personal characteristics. Results: A total of 721 dentists completed the survey, and the data from 688 questionnaires were included in the analysis. Conventional cementation was the option of choice for restorations fabricated from alloy/porcelain-fusedto- metal among 91.0% of the participants and for restorations fabricated from polycrystalline ceramics among 42.9% of the participants. Adhesive cementation was preferred for restorations fabricated from feldspathic/leucitereinforced glass ceramics (77.9%), lithium-disilicate glass ceramics (67.5%), zirconia-reinforced lithium-silicate glass ceramics (42.0%), and CAD/CAM resin composites (63.8%). Uncertainties regarding the appropriate cementation protocol for restorations fabricated from CAD/CAM resin composites were reported by 15% of the participants. More than 20% of the participants selected a technique that is less or not at all recommended for the cementation of restorations fabricated from zirconia-reinforced lithium-silicate glass ceramic and CAD/CAM resin composites. Conclusion: The results of the survey suggest that dentists in Germany select the cementation regime depending on the restorative material. Some of the participating dentists selected cementation regimens that are less or not at all recommended for restorations fabricated from zirconia-reinforced lithium-silicate glass ceramic and CAD/CAM resin composites, or were not sure about the appropriate cementation protocol.

Background: The aim of this study was to investigate the risk of cross-contamination in dental tray adhesives with reusable brush systems. Methods: Four dental tray adhesives with different disinfectant components were examined for risk as a potential transmission medium for Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus oralis, and Candida albicans. Bacterial and fungal strains were mixed with artificial saliva. The contaminated saliva was intentionally added to tray adhesive liquid samples. At baseline and up to 60 min, 100 microliters of each sample were collected and cultivated aerobically on Columbia and Sabouraud agar for 24 or 48 h, respectively. Results: At baseline, contamination with Staphylococcus aureus and Candida albicans could be identified in three out of four adhesives. In the subsequent samples, low counts of up to 20 colony-forming units per milliliter could be observed for Staphylococcus aureus. All other strains did not form colonies at baseline or subsequently. Adhesives with isopropanol or ethyl acetate as disinfectant additives were most effective in preventing contamination, while adhesives with hydrogen chloride or acetone as a disinfectant additive were the least effective. Conclusion: Within 15 min, the tested adhesives appeared to be sufficiently bactericidal and fungicidal against all microorganisms tested.

An abnormal development of teeth can result in malformed teeth. Indirect resin composites that can be fabricated with the computer-aided design/computer-aided manufacturing (CAD/ CAM) technique are available for the fabrication of permanent restorations. This case report presents the esthetical and functional rehabilitation of a 10-year-old female patient with oligodontia and conical canines.Crowns fabricated from indirect resin composites were milled and polished to restore the conical canines 23, 33, and 43 (FDI). In addition, direct resin composite fillings were applied to teeth 53, 52, and 11, and a resin-bonded fixed dental prosthesis with single-retainer design fabricated from zirconia ceramic that was partially veneered with silica-based ceramic was inserted to replace tooth 22.The young patient and her parents were very satisfied with the functional and esthetical results of the resin composite crowns after insertion. Oral hygiene measures were demonstrated, and could be easily realized by the girl. Since only a few clinical studies are available, the clinical longevity of permanent restorations fabricated from indirect resin composite has not yet been proven. In this case report, indirect resin composites were used to achieve esthetically and functionally pleasing results treating conical teeth.

Perception of tooth shades is subjective and not rated exactly the same by different individuals. In terms of dental esthetics, chairside individualization of dental restorations might help to improve patient satisfaction. This investigation aimed to validate the practicability of a chairside approach for staining resin-based composite restorations. Thirteen inexperienced and 13 experienced participants were recruited to first individualize two CAD/CAM resin-based composite crowns in randomized order with light-curing characterization material using two reference crowns as templates. They then evaluated the characterization procedure. The processing times were recorded, and the clinical quality of the individualized crowns was evaluated by two blinded master dental technicians. Of the 52 crowns examined, 90.4% were assessed as suitable for insertion; there was no difference in quality attributable to the different degrees of experience of the operators. The average time required for characterization of the second crown was significantly shorter than for the first crown (30.9/43.0 min), indicating that the procedure can be implemented using a chairside approach. Among the operators, 80.8% said they would use the individualization technique and staining material again. Chairside staining of CAD/CAM resin-based composite restorations with light-curing characterization materials is practicable and can be recommended for both experienced and inexperienced users.

Objectives: The aim of this project was to develop an instructional video that demonstrates a standardized clinical examination on patients with suspected temporomandibular disorders (TMD). After viewing the video, the learner should be knowledgeable about the examination steps and application of the examination techniques. Methods: The instructional video was created by two dentists who are experienced in assessing patients with suspected TMD. Additionally, both examiners were calibrated according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). The instructional video was divided into chapters. Various camera angles, key points, image enlargements, and replays were used to better depict essential aspects of the assessment. Background noise was reduced to a minimum. Results: The instructional video was modified and completed in two phases: the first by an experienced dentist and the second by a dentist specialized in TMD. The final video includes nine chapters and is 26.5 minutes in length ([link:https://doi.org/10.5061/dryad.k8r7qc1*https://doi.org/10.5061/dryad.k8r7qc1]). Conclusion: Divided into chapters, this German instructional video shows an optimally timed, standardized clinical assessment of patients with suspected TMD., Zielsetzung: Ziel dieser Arbeit war die Erstellung eines Instruktionsvideos, welches das Erlernen der Methodik zur Untersuchung von Patienten mit Verdacht auf craniomandibuläre Dysfunktionen (CMD) unterstützen soll. Nach Betrachten des Videos sollte der Lernende den Ablauf einer Untersuchung und die Anwendung der Untersuchungstechniken kennen. Methodik: Ein Instruktionsvideo wurde von zwei Zahnärzten, welche in der Befunderhebung von Patienten mit Verdacht auf CMD erfahren sind, angefertigt. Zusätzlich waren beide Untersucher gemäß der Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) kalibriert. Das Instruktionsvideo wurde in Kapiteln angelegt. Für eine verbesserte Darstellung wesentlicher Aspekte der Befunderhebung wurden verschiedene Kameraperspektiven, Stichpunkte, Bildvergrößerungen und Wiederholungen der Inhalte verwendet. Hintergrundgeräusche wurden auf ein Minimum reduziert. Ergebnisse: Mittels zweier Evaluationsphasen, wobei die erste durch erfahrene und die zweite durch auf CMD-spezialisierte Zahnärzte erfolgte, wurde das Instruktionsvideo sukzessive modifiziert und fertiggestellt. Das finale Video umfasst neun Kapitel und hat eine Gesamtdauer von 26,5 Minuten ([link:https://doi.org/10.5061/dryad.k8r7qc1*https://doi.org/10.5061/dryad.k8r7qc1]). Schlussfolgerung: Das deutsche Instruktionsvideo stellt den zeitlich optimierten Ablauf einer standardisierten Befunderhebung in Kapiteln dar, welche bei Patienten mit Verdacht auf craniomandibuläre Dysfunktion angewendet werden kann., GMS Journal for Medical Education; 37(4):Doc39

Journal of prosthodontic research 64(4), 498-505 (2020). doi:10.1016/j.jpor.2020.01.005, Published by Elsevier, Amsterdam [u.a.]

To date, risk factors for temporomandibular joint (TMJ) sounds are still not completely understood, and anatomical factors are suspected to influence their occurrence. This study aimed to evaluate the impact of body constitution on temporomandibular joint sounds of adolescents. 10- to 18-year-old participants of the LIFE Child Study were examined for TMJ sounds, and physical parameters such as body height, body weight, and general laxity of joints were measured. Odds ratios (OR) for associations of TMJ sounds and standard deviation scores (SDS) of body height and body weight were calculated by using binary logistic regression, including cofactors such as age and number of hypermobile joints. The OR for TMJ sounds and SDS of body height was 1.28 (95% confidence interval (CI) 1.06, 1.56) in females when the age-adjusted height value was above 0. SDS of body weight indicated significant ORs for TMJ sounds in males with values of 0.81 (95% CI 0.70, 0.94). No correlation was detected for SDS values and TMJ crepitus. Tall female adolescents seem to be more prone to TMJ clicking sounds, while their occurrence seems less likely in male adolescents with higher body weight.