58 results on '"Angela Vinturache"'
Search Results
2. Combination of medical and surgical management in successful treatment of caesarean scar pregnancy: a case report series
- Author
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Anda Pristavu, Angela Vinturache, Elena Mihalceanu, Radu Pintilie, Mircea Onofriescu, and Demetra Socolov
- Subjects
Caesarean scar pregnancy ,Transvaginal ultrasound ,Hormone chorionic gonadotropin ,Methotrexate ,Mifepristone ,Curettage ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background There is no clear consensus on the management of caesarean scar pregnancy (CSP), a complex and life-threatening condition. The objective of this study was to present a novel approach to management of CSP that combines medical therapy of multidose methotrexate and mifepristone with active surgical management by uterine curettage and consecutive local haemostasis. Case presentation We report on a prospective case series of six women with first trimester pregnancy, in whom the diagnosis of CSP was confirmed by 2D and color Doppler transvaginal ultrasound and serial hormone chorionic gonadotropin (hCG) testing. Women were between 23 and 36 years old and had at least one previous delivery by caesarean. At admission, gestational age ranged between 6 to 14 weeks, and serum hCG levels between 397 and 23,000 mUI/ml. Upon decision of pregnancy termination, medical management was undertaken in all cases and 1 mg/kg systemic Methotrexate was administered between 1 and 5 daily doses. Mifepristone was part of the treatment in cases with live pregnancy. Surgical management was employed for the cases were an embryo was seen by ultrasound, being prompted by inadequate response to Methotrexate and/or signs of miscarriage with vaginal bleeding. Curettage combined with local isthmic balloon or vaginal pack tamponade prevented further complications. High treatment rates with preservation of fertility was achieved in all patients except one who underwent hysterectomy for invasive placentation. Ultrasound and hCG levels surveillance ensured that the resolution of pregnancy was achieved. Conclusion Women with history of delivery by caesarean section should be carefully monitored in future pregnancies for prompt diagnosis of CSP. Early diagnosis of CSP allows selection of successful conservative therapy. Through this case series we contribute with our experience to the body of knowledge about the management of this serious complication of early pregnancy.
- Published
- 2020
- Full Text
- View/download PDF
3. The value of MRI in management of endometrial hyperplasia with atypia
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Purushothaman Natarajan, Angela Vinturache, Richard Hutson, David Nugent, and Timothy Broadhead
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Endometrial hyperplasia ,Myometrial invasion ,Endometrial cancer ,Magnetic resonance imaging ,Ultrasonography ,Sensitivity and specificity ,Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The value of the magnetic resonance imaging (MRI) in the assessment of women with endometrial hyperplasia and its role in diagnosis of myometrial invasion or coexistence of cancer is not known. This study aimed to evaluate the accuracy and usefulness of MRI in the management of patients diagnosed on endometrial biopsy with complex endometrial hyperplasia with atypia (CEHA). Methods A retrospective study of 86 cases diagnosed with endometrial hyperplasia with atypia on the initial endometrial biopsy in a tertiary university teaching hospital between 2010 and 2015 was carried out. The MRI accuracy in predicting malignant changes and influence the clinical management was compared among women who had either pelvic MRI, transvaginal ultrasound (TVUS), or no additional imagistic studies. Results MRI was performed in 24 (28%) and TVUS in 11 (13%)cases, while 51 (59%) women had no additional imagistic studies. In the group of women with no imaging studies, 26/51 (51%) were surgically treated and 8/26 (31%) were diagnosed with endometrial cancer (EEC) stage 1a. In the group of women who had TVUS, 5/11 (45%) were surgically treated and none was diagnosed with EEC. In the group of women who underwent an MRI examination, 20/24 (83%) were surgically treated. Among these, 11/20 (55%) were diagnosed with EEC, 7 had EEC stage 1a, and 4 had EEC stage 1b. Although MRI was able to identify malignant changes with a good sensitivity (91.7%), it had a low specificity in characterisation of malignant transformation (8%). MRI correctly identified 31% of the stage 1a and 33% of the stage 1b endometrial cancer. Conclusion In this study, we found a potential diagnostic value of MRI for identifying malignant transformation in patients with CEHA. However, pelvic MRI has a rather weak predictive value of myometrial invasion in women with CEHA and concurrent EEC. The diagnostic and therapeutic benefits of MRI assessment in patients with CEHA need further validation.
- Published
- 2020
- Full Text
- View/download PDF
4. Birth trauma in preterm spontaneous vaginal and cesarean section deliveries: A 10-years retrospective study.
- Author
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Alina Luca, Angela Vinturache, Ciprian Ilea, Andreea Avasiloaiei, Luminita Paduraru, Alexandru Carauleanu, Ioana Sripcariu, and Demetra Socolov
- Subjects
Medicine ,Science - Abstract
ObjectiveWe compared birth injuries for spontaneous vaginal (VD) and caesarean section (CS) deliveries in preterm and term pregnancies.MethodsA retrospective cohort study was conducted in a single tertiary center, between January 1st, 2007, and December 31st, 2017. The study included 62330 singleton pregnancies delivered after 24 0/7 weeks gestation. Multivariable analyses compared trauma at birth, birth hypoxia and birth asphyxia in term and preterm deliveries, stratified by mode of birth, VD versus CS. Main outcome measure was trauma at birth including intracranial laceration and haemorrhage, injuries to scalp, injuries to central and peripheral nervous system, fractures to skeleton, facial and eye injury.ResultsThe incidence of preterm deliveries was 10.9%. Delivery of preterm babies by CS increased from 37.0% in 2007 to 60.0% in 2017. The overall incidence of all birth trauma was 16.2%. When stratified by mode of delivery, birth trauma was recorded in 23.4% of spontaneous vaginal deliveries and 7.5% of CS deliveries (aOR 3.3, 95%CI 3.1-3.5). When considered all types of birth trauma, incidence of trauma at birth was higher after 28 weeks gestation in VD compared to CS (28-31 weeks, aOR 1.7, 95% CI 1.3-2.3; 32-36 weeks, aOR 4.2, 95% CI 3.6-4.9; >37 weeks, aOR 3.3, 95% CI 3.1-3.5). There was no difference in the incidence of birth trauma before 28 weeks gestation between VD and CS (aOR 0.8, 95% CI 0.5-1.2). Regarding overall life-threatening birth trauma or injuries at birth with severe consequences such as cerebral and intraventricular haemorrhage, cranial and brachial nerve injury, fractures of long bones and clavicle, eye and facial injury, there was no difference in vaginal preterm deliveries compared to CS deliveries (p > 0.05 for all).ConclusionCS is not protective of injury at birth. When all types of birth trauma are considered, these are more common in spontaneous VD, thus favoring CS as preferred method of delivery to avoid trauma at birth. However, when stratified by severity of birth trauma, preterm babies delivered vaginally are not at higher risk of major birth trauma than those delivered by CS.
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- 2022
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5. Women’s recall of health care provider counselling on gestational weight gain (GWG): a prospective, population-based study
- Author
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Angela Vinturache, Anika Winn, Cynthia Mannion, and Suzanne Tough
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Gestational weight gain ,Obesity in pregnancy ,Prenatal counselling ,Women experiences ,Health care provider ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Prenatal care has been validated to provide medical and educational counselling intended to reduce the risk of adverse pregnancy conditions and improve the maternal and fetal outcomes. Prenatal targeted information regarding nutrition, lifestyle, and weight gain is predictive of meeting Institute of Medicine (IOM) 2009 gestational weight gain (GWG) guidelines. There is limited information about women’s experiences with these prenatal counselling domains, particularly in women who do not meet GWG recommendations. The objective of this study was to evaluate the impact of women’s recall of prenatal counselling and its effect on meeting their GWG within guidelines in a prospective, community-based pregnancy cohort. Methods A sample of 2909 women with singleton pregnancies was drawn from the prospective community-based pregnancy cohort All Our Families from Alberta, Canada. Women were stratified into three GWG groups, adequate, inadequate, and excessive GWG, based on pre-pregnancy BMI and the adherence to the Institute of Medicine weight gain in pregnancy guidelines. At less than 25 and 34 to 36 weeks’ gestation, maternal socio-demographic information and women’s recall of prenatal counselling experiences was collected through self-administered questionnaires. Multivariate logistic regression analyses tested GWG strata impact on women’s recall of the prenatal counselling advice in eight domains of nutrition, lifestyle, and weight management during pregnancy. Results Adequate GWG was reached by 35.9% of women, 46.5% gained excessive and 17.6% gained inadequate weight. Women who were overweight and obese prior to pregnancy were more likely to gain excessive weight than women who were normal weight (OR 3.3, 95% CI 2.6–4.1; and OR 2.9, 95% CI 2.1–3.9, respectively). Most women reported having no difficulties in finding prenatal care, felt comfortable with their health care provider and were satisfied with the answers received. There was no difference in the recall of prenatal advice received in any of the eight domains of prenatal counselling assessed among women with appropriate and non-optimal GWG. Conclusion Women with adequate and non-optimal GWG received comparable prenatal counselling on nutrition, weight gain, and lifestyle modifications. There remain missed opportunities in targeting prenatal counselling advice to women at risk for suboptimal or excessive GWG.
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- 2019
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6. Risk Factors for Urological Complications Associated with Caesarean Section—A Case-Control Study
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Viorel Dragos Radu, Anda Ioana Pristavu, Angela Vinturache, Pavel Onofrei, Demetra Gabriela Socolov, Alexandru Carauleanu, Lucian Boiculese, Sadyie Ioana Scripcariu, and Radu Cristian Costache
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urologic complications ,bladder injury ,ureter injury ,caesarean hysterectomy ,placenta accreta ,placenta previa ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Acute urologic complications, including bladder and/or ureteric injury, are rare but known events occurring at the time of caesarean section (CS). Delayed or inadequate management is associated with increased morbidity and poor long-term outcomes. We conducted this study to identify the risk factors for urologic injuries at CS in order to inform obstetricians and patients of the risks and allow management planning to mitigate these risks. Materials and Methods: We reviewed all cases of urological injuries that occurred at CS surgeries in a tertiary university centre over a period of four years, from January 2016 to December 2019. To assess the risk factors of urologic injuries, a case-control study of women undergoing caesarean delivery was designed, matched 1:3 to randomly selected women who had an uncomplicated CS. Electronic medical records and operative reports were reviewed for socio-demographic and clinical information. Descriptive and univariate analyses were used to characterize the study population and identify the risk factors for urologic complications. Results: There were 36 patients with urologic complications out of 14,340 CS patients, with an incidence of 0.25%. The patients in the case group were older, had a lower gestational age at time of delivery and their newborns had a lower birth weight. Prior CS was more prevalent among the study group (88.2 vs. 66.7%), as was the incidence of placenta accreta and central praevia. In comparison with the control group, the intraoperative blood loss was higher in the case group, although there was no difference among the two groups regarding the type of surgery (emergency vs. elective), uterine rupture, or other obstetrical indications for CS. Prior CS and caesarean hysterectomy were risk factors for urologic injuries at CS. Conclusions: The major risk factor for urological injuries at the time of CS surgery is prior CS. Among patients with previous CS, those who undergo caesarean hysterectomy for placenta previa central and placenta accreta are at higher risk of surgical haemostasis and complex urologic injuries involving the bladder and the ureters.
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- 2022
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7. Association of perfluoroalkyl substances with pulmonary function in adolescents (NHANES 2007–2012)
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Shuang Shi, Ying Ding, Beirong Wu, Peipei Hu, Ming Chen, Na Dong, Angela Vinturache, Haoxiang Gu, Xiaoyan Dong, and Guodong Ding
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Health, Toxicology and Mutagenesis ,Environmental Chemistry ,General Medicine ,Pollution - Published
- 2023
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8. Risk Factors for Maternal Body Mass Index and Gestational Weight Gain in Twin Pregnancies
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Julia, Schubert, Nina, Timmesfeld, Kathrin, Noever, Susann, Behnam, Angela, Vinturache, and Birgit, Arabin
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Maternity and Midwifery ,Obstetrics and Gynecology - Abstract
Objective This retrospective cohort study analyzes risk factors for abnormal pre-pregnancy body mass index and abnormal gestational weight gain in twin pregnancies. Methods Data from 10 603/13 682 twin pregnancies were analyzed using uni- and multivariable logistic regression models to determine risk factors for abnormal body mass index and weight gain in pregnancy. Results Multiparity was associated with pre-existing obesity in twin pregnancies (aOR: 3.78, 95% CI: 2.71 – 5.27). Working in academic or leadership positions (aOR: 0.57, 95% CI: 0.45 – 0.72) and advanced maternal age (aOR: 0.96, 95% CI: 0.95 – 0.98) were negatively associated with maternal obesity. Advanced maternal age was associated with a lower risk for maternal underweight (aOR: 0.95, 95% CI: 0.92 – 0.99). Unexpectedly, advanced maternal age (aOR: 0.98, 95% CI: 0.96 – 0.99) and multiparity (aOR: 0.6, 95% CI: 0.41 – 0.88) were also associated with lower risks for high gestational weight gain. Pre-existing maternal underweight (aOR: 1.55, 95% CI: 1.07 – 2.24), overweight (aOR: 1.61, 95% CI: 1.39 – 1.86), obesity (aOR: 3.09, 95% CI: 2.62 – 3.65) and multiparity (aOR: 1.64, 95% CI: 1.23 – 2.18) were all associated with low weight gain. Women working as employees (aOR: 0.85, 95% CI: 0.73 – 0.98) or in academic or leadership positions were less likely to have a low gestational weight gain (aOR: 0.77, 95% CI: 0.64 – 0.93). Conclusion Risk factors for abnormal body mass index and gestational weight gain specified for twin pregnancies are relevant to identify pregnancies with increased risks for poor maternal or neonatal outcome and to improve their counselling. Only then, targeted interventional studies in twin pregnancies which are desperately needed can be performed.
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- 2022
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9. Hydropneumothorax and atelectasis associated with Mycoplasma pneumoniae pneumonia in a 11‐year‐old girl
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Shuang Shi, Na Dong, Angela Vinturache, Xiaoyan Dong, and Guodong Ding
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Pulmonary and Respiratory Medicine ,Pulmonary Atelectasis ,Hydropneumothorax ,Pneumonia, Mycoplasma ,Pediatrics, Perinatology and Child Health ,Humans ,Female ,Child ,Mycoplasma pneumoniae - Published
- 2022
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10. Relationship of maternal obesity and vitamin D concentrations with fetal growth in early pregnancy
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Angela Vinturache, Meng Ni, Zhiwei Liu, Jiuru Zhao, Qianqian Zhang, Chen Zhang, Qianwen Shen, Yi Wang, Hao Chen, Haiyuan Li, Xiaoli Wang, and Fengxiu Ouyang
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Vitamin ,medicine.medical_specialty ,Population ,Medicine (miscellaneous) ,Overweight ,Fetal Development ,Obesity, Maternal ,chemistry.chemical_compound ,Pregnancy ,medicine ,Vitamin D and neurology ,Humans ,Vitamin D ,Child ,education ,Retrospective Studies ,Crown-rump length ,education.field_of_study ,Fetal Growth Retardation ,Nutrition and Dietetics ,Obstetrics ,business.industry ,Vitamins ,medicine.disease ,Obesity ,chemistry ,Gestation ,Female ,medicine.symptom ,business ,Body mass index - Abstract
Purpose To evaluate the effects of the association between first trimester vitamin D (VitD) concentrations and increased prepregnancy body mass index (BMI) on early fetal growth restriction (FGR). Methods This retrospective cohort study included 15,651 women with singleton pregnancy who delivered at the International Peace Maternity and Child Health Hospital between January 2015 and November 2016. Women were classified in two groups based on their serum 25(OH)D vitamin levels status: VitD sufficient (SUFF) group and VitD insufficient or deficient (INSUFF/DEF). The cut-off point for VitD concentration was 50.00 nmol/L. Comparisons were made between women with normal prepregnancy body weight (BMI 18.5–23.9 kg/m2) and overweight and obese (OWO) women (BMI > 24.0 kg/m2). Early FGR was defined as first-trimester gestational age-adjusted crown-rump length (CRL) in the lowest 20th centile of the population. Multivariate logistic regression was used to evaluate the association between maternal serum 25(OH)D levels and prepregnancy BMI with first trimester CRL and early FGR. Results In VitD INSUFF/DEF group, the first trimester CRL was decreased (P = 0.005), and the risk of early FGR was increased by 13% (95% CI 1.04–1.24, P = 0.004) compared to the VitD SUFF group. In OWO group, the first trimester CRL was also significantly decreased (P P P for interaction = 0.02) and the risk of early FGR (P for interaction = 0.07). Conclusion Sufficient first trimester serum 25(OH)D concentration was a protective factor for early fetal growth, especially among OWO mothers. Chinese Clinical Trial Registry (Registration number: ChiCTR1900027447 with date of registration on November 13, 2019-retrospectively registered).
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- 2021
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11. Corps étranger sous-glottique chez un bébé de 18 mois
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Haoxiang Gu, Angela Vinturache, and Guodong Ding
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General Medicine - Published
- 2023
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12. Nickel allergic contact dermatitis
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Mingang Zhu, Angela Vinturache, and Guodong Ding
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Nickel ,Dermatitis, Allergic Contact ,Humans ,General Medicine ,Patch Tests - Published
- 2022
13. Impact of maternal body mass index and gestational weight gain on maternal and neonatal outcomes in twin pregnancies
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Julia Schubert, Nina Timmesfeld, Kathrin Noever, Susann Behnam, Angela Vinturache, and Birgit Arabin
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Obstetrics and Gynecology ,General Medicine - Abstract
To date, there have only been provisional recommendations about the appropriate gestational weight gain in twin pregnancies. This study aimed to contribute evidence to this gap of knowledge.Using a cohort of 10 603 twin pregnancies delivered between 2000 and 2015 in the state of Hessen, Germany, the individual and combined impact of maternal body mass index and gestational weight gain on maternal and neonatal outcomes was analyzed using uni- and multivariable logistic regression models. The analysis used newly defined population-based quartiles of gestational weight gain in women carrying twin pregnancies (Q1:419.4 g/week [low weight gain], Q2-Q3: 419.4-692.3 g/week [optimal weight gain], Q4:692.3 g/week [high weight gain]) and the World Health Organization body mass index classification.Pre-pregnancy body mass index ≥25 kg/mIn twin pregnancies, nonoptimal weekly maternal weight gain seems to be strongly associated with maternal and neonatal adverse outcomes. Since gestational weight gain is a modifiable risk factor, health care providers have the opportunity to counsel pregnant women with twins and target their care accordingly. Additional research to confirm the validity and generalizability of our findings in different populations is warranted.
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- 2022
14. Staphylococcal scalded skin syndrome in a child
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Qinwei Qian, Jinyue Shen, Angela Vinturache, and Guodong Ding
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Infectious Diseases - Published
- 2023
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15. Dermatite de contact allergique au nickel
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Mingang Zhu, Angela Vinturache, and Guodong Ding
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General Medicine - Published
- 2022
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16. Prenatal pyrethroid exposure and lung function among school-aged children
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Peipei Hu, Yan Zhang, Angela Vinturache, Ying Tian, Yi Hu, Yu Gao, and Guodong Ding
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Male ,Insecticides ,Pregnancy ,Pyrethrins ,Public Health, Environmental and Occupational Health ,Linear Models ,Humans ,Female ,Environmental Exposure ,Child ,Lung ,Gas Chromatography-Mass Spectrometry - Abstract
Previous epidemiological evidence mainly focused on the adverse effects of prenatal exposure to pyrethroid insecticides (PYRs) on respiratory health during childhood. It remains unclear whether the PYR exposures can also impact on children's lung function.To explore the potential effects of prenatal PYR exposures on lung function in a population of Chinese children.This study included 233 mother-child dyads from the Laizhou Wan Birth Cohort (LWBC), Shandong province, northern China, between September 2010 and December 2013. Three metabolites of PYRs [3-phenoxybenzoic acid (3-PBA), and cis- and trans-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (cis-DCCA and trans-DCCA)] were measured using gas chromatography-mass spectrometry (GC-MS) in maternal urine samples collected at recruitment. Lung function was assessed with spirometry in children aged 6-8 years. Multivariable linear regression and generalized linear models (GLMs) assessed the associations of prenatal PYR exposures with lung function in children.Among the PYR metabolites, 3-PBA (81.5%) were most frequently detected, followed by trans-DCCA (55.4%) and cis-DCCA (21.9%). The 3-PBA concentration was associated with a 1% decrease in FEVPrenatal 3-PBA concentrations were associated with a modest decrease in FEV
- Published
- 2022
17. Combination of medical and surgical management in successful treatment of caesarean scar pregnancy: a case report series
- Author
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Radu Pintilie, Demetra Socolov, Mircea Onofriescu, Anda Pristavu, Angela Vinturache, and Elena Mihalceanu
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Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Case Report ,lcsh:Gynecology and obstetrics ,Miscarriage ,Curettage ,03 medical and health sciences ,Cicatrix ,Young Adult ,0302 clinical medicine ,Hormone chorionic gonadotropin ,Pregnancy ,medicine ,Caesarean scar pregnancy ,Humans ,Caesarean section ,Vaginal bleeding ,030212 general & internal medicine ,Prospective Studies ,Ultrasonography, Doppler, Color ,lcsh:RG1-991 ,030219 obstetrics & reproductive medicine ,Hysterectomy ,business.industry ,Obstetrics ,Cesarean Section ,Transvaginal ultrasound ,Uterus ,Obstetrics and Gynecology ,Gestational age ,Fertility Preservation ,Abortion, Induced ,Uterine Artery Embolization ,medicine.disease ,Combined Modality Therapy ,Pregnancy Complications ,Pregnancy Trimester, First ,Mifepristone ,Treatment Outcome ,Methotrexate ,Female ,Tamponade ,Uterine Hemorrhage ,medicine.symptom ,business - Abstract
Background There is no clear consensus on the management of caesarean scar pregnancy (CSP), a complex and life-threatening condition. The objective of this study was to present a novel approach to management of CSP that combines medical therapy of multidose methotrexate and mifepristone with active surgical management by uterine curettage and consecutive local haemostasis. Case presentation We report on a prospective case series of six women with first trimester pregnancy, in whom the diagnosis of CSP was confirmed by 2D and color Doppler transvaginal ultrasound and serial hormone chorionic gonadotropin (hCG) testing. Women were between 23 and 36 years old and had at least one previous delivery by caesarean. At admission, gestational age ranged between 6 to 14 weeks, and serum hCG levels between 397 and 23,000 mUI/ml. Upon decision of pregnancy termination, medical management was undertaken in all cases and 1 mg/kg systemic Methotrexate was administered between 1 and 5 daily doses. Mifepristone was part of the treatment in cases with live pregnancy. Surgical management was employed for the cases were an embryo was seen by ultrasound, being prompted by inadequate response to Methotrexate and/or signs of miscarriage with vaginal bleeding. Curettage combined with local isthmic balloon or vaginal pack tamponade prevented further complications. High treatment rates with preservation of fertility was achieved in all patients except one who underwent hysterectomy for invasive placentation. Ultrasound and hCG levels surveillance ensured that the resolution of pregnancy was achieved. Conclusion Women with history of delivery by caesarean section should be carefully monitored in future pregnancies for prompt diagnosis of CSP. Early diagnosis of CSP allows selection of successful conservative therapy. Through this case series we contribute with our experience to the body of knowledge about the management of this serious complication of early pregnancy.
- Published
- 2020
- Full Text
- View/download PDF
18. Maternal preconception body mass index and time-to-pregnancy in Shanghai Women, China
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Peipei Hu, Jing Qiao, Jun Zhang, Ying Tian, Guodong Ding, Yu Gao, Min Lu, Yi Hu, Angela Vinturache, Haoxiang Gu, and Chen Cai
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Adult ,Infertility ,China ,media_common.quotation_subject ,Fertility ,Body size ,Body Mass Index ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Thinness ,Pregnancy ,medicine ,Body Size ,Humans ,Obesity ,030212 general & internal medicine ,media_common ,030219 obstetrics & reproductive medicine ,business.industry ,General Medicine ,Overweight ,medicine.disease ,Time to pregnancy ,Time-to-Pregnancy ,Female ,business ,Infertility, Female ,Body mass index ,Demography - Abstract
Previous studies suggested an association between female fertility and body size, but most of these studies were from Western countries and focused mainly on obesity. This study investigated the association between preconception body mass index (BMI) and time to pregnancy (TTP) in women planning to conceive from Shanghai, China. A total of 1,182 women aged 24-46 years were recruited from the Shanghai Birth Cohort between 2013 and 2015 and were followed up for 12 months. Preconception BMI was categorized as underweight, normal weight, and overweight/obesity according to the Chinese classification of BMI. Fecundability (FOR) and infertility (IOR) odds ratios were estimated using Cox (n = 1,092) and Logistic (n = 820) regression models, respectively. We found no differences in fecundability between underweight and overweight/obese women and normal-weight women. Furthermore, underweight and overweight/obese women did not have a higher risk of infertility compared with normal-weight women. Our findings suggest that non-optimal preconception BMI does not appear to influence female fecundability and infertility in Chinese women. These results should be interpreted with caution as they may be applicable only to women with demographic and anthropometric characteristics similar to our study population. Our findings need to be confirmed in other populations.
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- 2020
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19. Conservative in utero treatment of fetal dyshormonogenetic goiter with levothyroxine, a systematic literature review
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Ingrid Andrada Tanasa, Angela Vinturache, Dragos Nemescu, Dan Navolan, and Dana Stoian
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0301 basic medicine ,Cancer Research ,Pediatrics ,medicine.medical_specialty ,endocrine system ,Goiter ,dyshormonogenesis ,endocrine system diseases ,Levothyroxine ,fetal goiter ,Prenatal diagnosis ,in utero ,03 medical and health sciences ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,medicine ,Pregnancy ,Fetus ,medicine.diagnostic_test ,business.industry ,Thyroid ,General Medicine ,Articles ,medicine.disease ,L-thyroxine ,030104 developmental biology ,medicine.anatomical_structure ,In utero ,030220 oncology & carcinogenesis ,Amniocentesis ,amniocentesis ,pregnancy ,business ,cordocentesis ,medicine.drug - Abstract
Fetal goitrous hypothyroidism is a rare condition associated with important obstetrical, neonatal complications, and neurodevelopmental impairments. Prenatal treatment remains controversial, and the risk to benefit ratio must be accurately assessed and considered for individualized management. The objective of this review was to evaluate the feasibility, safety, and effectiveness of the conservative in utero treatment of fetal goitrous hypothyroidism. In total, 25 reports that met our inclusion criteria were selected and the management of 38 cases was analyzed. Prenatal diagnosis consisted mainly of ultrasonographic findings. Fetal thyroid status was assessed by cordocentesis. Prenatal treatment varied widely in terms of levothyroxine (LT4) route of administration, dosage, number of injections, and frequency. Although different regimens and routes of administration were proposed, they seem to have similar results regarding fetal goiter reduction and thyroid status at birth. At birth, most babies had hypothyroidism, but the long-term follow-up indicated a normal psycho-neuromotor development. Our data confirm the feasibility of conservative treatment with LT4 for fetal goitrous hypothyroidism. Further studies are needed to determine the optimal management of this disorder.
- Published
- 2020
20. 'Doing the month' and postpartum depression among Chinese women: A Shanghai prospective cohort study
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Min Lu, Lei Niu, Angela Vinturache, Guodong Ding, Jun Zhang, Shuming Pan, Ying Tian, and Yu Gao
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Postpartum depression ,China ,030219 obstetrics & reproductive medicine ,030504 nursing ,business.industry ,Obstetrics and Gynecology ,Logistic regression ,medicine.disease ,Modern life ,Depression, Postpartum ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Edinburgh Postnatal Depression Scale ,Maternity and Midwifery ,Humans ,Childbirth ,Medicine ,Female ,Prospective Studies ,Doing the month ,0305 other medical science ,business ,Prospective cohort study ,Demography - Abstract
Background The Chinese postpartum custom of “doing the month” characterized by generous social support available through the traditional cultural practices was considered to protect women from postpartum depression in early puerperium. Methods This study used data from the Shanghai Birth Cohort, a study of 2615 postpartum women from Shanghai, China, that was conducted between 2013 and 2016. Detailed information on the traditional “doing the month” practices and the on the Edinburgh Postnatal Depression Scale scores was collected from questionnaires administered on the 42nd day after childbirth. Logistic regression models were used to examine the association between the adopting traditional puerperium practices and postpartum depression. Results The estimated prevalence of postpartum depression in women from the Shanghai area in China was 11.8% (n = 308) at six weeks postpartum. Women who went outside their homes during the first month postpartum showed higher risks of postpartum depression compared with those who never left the house (1–2 times: OR = 1.9, 95% CI = 1.4–2.4; 3–5 times: OR = 2.3, 95% CI = 1.5–3.5; ≥6 times: OR = 2.5, 95% CI = 1.2–5.1). Women with average sleep of 6 h or less per night were more likely to suffer from postpartum depression compared with those who slept 8 h (6 h: OR = 1.7, 95% CI = 1.2–2.4; less than 6 h : OR = 3.3, 95% CI = 2.2–5.0). Women who opened the house windows most of the time exhibited decreased risks of postpartum depression compared to those who never or rarely opened the windows (often: OR = 0.6, 95% CI = 0.4–0.9; always: OR = 0.4, 95% CI = 0.3–0.7). Conclusions Our results suggested that not all the activities of “doing the month” provided protection against developing PPD. This study emphasized the need for flexibility to fit and adjust the ritual into the modern life to enhance the positive effects of traditional practices on maternal health.
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- 2020
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21. The value of MRI in management of endometrial hyperplasia with atypia
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Angela Vinturache, Richard Hutson, Purushothaman Natarajan, David Nugent, and T Broadhead
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Biopsy ,Endometrial hyperplasia ,Endometrium ,0302 clinical medicine ,Endometrial cancer ,Atypia ,Stage (cooking) ,Ultrasonography ,Aged, 80 and over ,Complex Endometrial Hyperplasia with Atypia ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,Middle Aged ,Prognosis ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cell Transformation, Neoplastic ,Sensitivity and specificity ,Oncology ,030220 oncology & carcinogenesis ,Myometrium ,Female ,Radiology ,Adult ,medicine.medical_specialty ,Clinical Decision-Making ,lcsh:Surgery ,Hysterectomy ,lcsh:RC254-282 ,03 medical and health sciences ,Magnetic resonance imaging ,Predictive Value of Tests ,Preoperative Care ,medicine ,Humans ,Neoplasm Invasiveness ,Aged ,Retrospective Studies ,Myometrial invasion ,business.industry ,Research ,Patient Selection ,Retrospective cohort study ,lcsh:RD1-811 ,medicine.disease ,Endometrial Neoplasms ,Surgery ,business ,Follow-Up Studies ,Endometrial biopsy - Abstract
Background The value of the magnetic resonance imaging (MRI) in the assessment of women with endometrial hyperplasia and its role in diagnosis of myometrial invasion or coexistence of cancer is not known. This study aimed to evaluate the accuracy and usefulness of MRI in the management of patients diagnosed on endometrial biopsy with complex endometrial hyperplasia with atypia (CEHA). Methods A retrospective study of 86 cases diagnosed with endometrial hyperplasia with atypia on the initial endometrial biopsy in a tertiary university teaching hospital between 2010 and 2015 was carried out. The MRI accuracy in predicting malignant changes and influence the clinical management was compared among women who had either pelvic MRI, transvaginal ultrasound (TVUS), or no additional imagistic studies. Results MRI was performed in 24 (28%) and TVUS in 11 (13%)cases, while 51 (59%) women had no additional imagistic studies. In the group of women with no imaging studies, 26/51 (51%) were surgically treated and 8/26 (31%) were diagnosed with endometrial cancer (EEC) stage 1a. In the group of women who had TVUS, 5/11 (45%) were surgically treated and none was diagnosed with EEC. In the group of women who underwent an MRI examination, 20/24 (83%) were surgically treated. Among these, 11/20 (55%) were diagnosed with EEC, 7 had EEC stage 1a, and 4 had EEC stage 1b. Although MRI was able to identify malignant changes with a good sensitivity (91.7%), it had a low specificity in characterisation of malignant transformation (8%). MRI correctly identified 31% of the stage 1a and 33% of the stage 1b endometrial cancer. Conclusion In this study, we found a potential diagnostic value of MRI for identifying malignant transformation in patients with CEHA. However, pelvic MRI has a rather weak predictive value of myometrial invasion in women with CEHA and concurrent EEC. The diagnostic and therapeutic benefits of MRI assessment in patients with CEHA need further validation.
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- 2020
22. Mediastinal mass in an 11-year-old boy
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Guodong Ding, Xiaoyan Dong, Angela Vinturache, Zhengwen Xing, Rufang Zhang, and Li Shen
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Pulmonary and Respiratory Medicine ,Male ,Pediatrics, Perinatology and Child Health ,Mediastinal Diseases ,Humans ,Child ,Tomography, X-Ray Computed ,Mediastinal Neoplasms - Published
- 2022
23. Therapeutic plasma exchange combined with continuous venovenous hemofiltration in a series of pediatric patients with toxic epidermal necrolysis
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Angela Vinturache, Chunxia Wang, Yucai Zhang, Guodong Ding, Yun Cui, and Jingyi Shi
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Male ,medicine.medical_specialty ,Continuous Renal Replacement Therapy ,Plasma Exchange ,business.industry ,Infant ,Dermatology ,medicine.disease ,Toxic epidermal necrolysis ,Continuous venovenous hemofiltration ,Child, Preschool ,Stevens-Johnson Syndrome ,Correspondence ,Humans ,Medicine ,Therapeutic plasma exchange ,business - Published
- 2021
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24. Associations between exposure to a mixture of phenols, parabens, and phthalates and sex steroid hormones in children 6-19 years from NHANES, 2013-2016
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Peipei Hu, Chengyu Pan, Weiwei Su, Angela Vinturache, Yi Hu, Xiaoyan Dong, and Guodong Ding
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Adult ,Male ,Environmental Engineering ,Adolescent ,Phthalic Acids ,Parabens ,Bayes Theorem ,Environmental Exposure ,Nutrition Surveys ,Pollution ,Young Adult ,Phenols ,Environmental Chemistry ,Humans ,Environmental Pollutants ,Female ,Child ,Gonadal Steroid Hormones ,Waste Management and Disposal - Abstract
Humans are typically exposed to mixtures of environmental endocrine-disrupting chemicals simultaneously, but most studies have considered only a single chemical or a class of similar chemicals.We examined the association of exposure to mixtures of 7 chemicals, including 2 phenols [bisphenol A (BPA) and bisphenol S (BPS)], 2 parabens [methylparaben (MeP) and propyl paraben (PrP)], and 3 phthalate metabolites [Mono-benzyl phthalate (MBzP), mono-isobutyl phthalate (MiBP), mono (carboxyoctyl) phthalate (MCOP)] with sex steroid hormones.A total of 1179 children aged 6-19 years who had complete data on both 7 chemicals and sex steroid hormones of estradiol (EThe linear regression showed that 2 phenols, 2 parabens, and 3 phthalate metabolites were generally negatively associated with EExposure to phenols, parabens, and phthalates, either individuals or as a mixture, was negatively associated with E
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- 2021
25. Thyroid hormone concentrations in second trimester of gestation and birth outcomes in Shanghai, China
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Yu Gao, Min Lu, Peipei Hu, Chen Cai, Angela Vinturache, Haoxiang Gu, Ying Tian, Wei Chen, Jing Qiao, Fang Liu, and Guodong Ding
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China ,Thyroid Hormones ,medicine.medical_specialty ,Thyroid Gland ,Thyrotropin ,Pregnancy ,Second trimester ,Fetal growth ,Birth Weight ,Humans ,Medicine ,Shanghai china ,business.industry ,Obstetrics ,Thyroid ,Infant, Newborn ,Obstetrics and Gynecology ,Thyroxine ,First trimester ,medicine.anatomical_structure ,Pregnancy Trimester, Second ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,Thyroid function ,business ,Hormone - Abstract
Previous studies suggested that thyroid function in the first trimester of gestation played an important role in fetal growth. However, limited clinical data are available to support this relationship in the second trimester of gestation.We examined the relationship of maternal thyroid function parameters in early second trimester of gestation with birth outcomes in China.Participating 5016 mother-infant pairs were recruited from the Songjiang District Maternity and Infant Hospital, Shanghai, China, between July and December 2016. Linear regression assessed the associations of thyroid hormones with birthweight. Logistic regression tested the correlations between thyroid hormones and low birthweight, macrosomia, small for gestational age , and large for gestational age infants. Maternal serum TSH, TT3, TT4, FT3, and FT4 concentrations were measured in 16-20 weeks of gestation.TT3 and FT3 were positively associated with birthweight, while TT4 and FT4 were negatively associated with birthweight, respectively. Furthermore, higher TT3 and FT3 were associated with increased risks of LGA infants (OR = 1.48, 95% CI: 1.15-1.9; OR = 1.22, 95% CI: 1.01-1.46), respectively. Higher TT3 was associated with an increased risk of macrosomic infants (OR = 1.35, 95% CI: 1.04-1.74). In contrast, higher FT4 was associated with decreased risks of LGA (OR = 0.87, 95% CI: 0.81-0.93) and macrosomic infants (OR = 0.90, 95% CI: 0.84-0.96), respectively. No associations were found between TSH and any of the outcomes.TT3 and FT3 were positively associated with fetal growth, while TT4 and FT4 were negatively associated with fetal growth. Our findings suggested that thyroid function in early second trimester of gestation is a potential risk factor for abnormal fetal growth.
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- 2019
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26. Subglottic airway foreign body in an 18-month-old girl
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Haoxiang, Gu, Angela, Vinturache, and Guodong, Ding
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Humans ,Infant ,Female ,General Medicine ,Thorax ,Foreign Bodies - Published
- 2022
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27. Urinary organophosphate metabolite concentrations and birth sizes among women conceiving through in vitro fertilization in Shanghai, China
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Peipei Hu, Hong Li, Angela Vinturache, Ying Tian, Chengyu Pan, Yi Hu, Yu Gao, Zhiwei Liu, and Guodong Ding
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Male ,China ,Infant, Newborn ,Infant ,Fertilization in Vitro ,Biochemistry ,Organophosphates ,Cohort Studies ,Organophosphorus Compounds ,Humans ,Premature Birth ,Female ,Pesticides ,General Environmental Science - Abstract
Few studies have examined the adverse birth sizes of preconception exposure to organophosphate pesticides (OPs) in women undergoing in vitro fertilization (IVF).We investigated the relationship of preconception OP exposure with birth sizes among Chinese women undergoing IVF.This study included 302 couples seeking infertility treatment in the China National Birth Cohort Study, from Shanghai, China, who gave birth to singleton infants between 2018 and 2021. Clinical data were collected from medical records. We measured the concentrations of six nonspecific dialkyl phosphates (DAP) metabolites of OPs [diethylthiophosphate (DETP), diethylphosphate (DEP), diethyldithiophosphate (DEDTP), dimethyldithiophosphate (DMTP), dimethylphosphate (DMP), and dimethyldithiophosphate (DMDTP)] in maternal urine. DMDTP and DEDTP were precluded from further analyses due to the low detection rates. Generalized linear models (GLMs) and weighted quantile sum (WQS) regression analyses were performed to examine the individual and joint effects of OP exposures on gestational age, birth weight, body length, and ponderal index. Odder ratio (OR) of preterm birth were estimated using logistic regression models.Women in the highest as compared with lowest quartile of DEP had shorter gestational age (β = - 0.68; 95% CI = -1.24, -0.11). The association was modified by sex, with boys showing larger decreases in gestational age (β = - 0.86; 95% CI = -1.60, -0.13). No associations were found between other DAP metabolites and birth sizes. Results from linear models with individual DAP metabolites were corroborated by the WQS regression where DEP had the largest contribution to the overall mixture effect on gestational age (weight = 0.70). Moreover, DEP concentration was associated with an elevated risk of preterm birth (OR = 1.35, 95% CI = 1.11, 2.25).Preconception DEP concentration was associated with shortened gestational age and increased risk of preterm birth, and the association was more pronounced among boys than girls.
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- 2022
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28. Eczema Herpeticum in an Infant
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Guifeng Chen, Zhongjie Li, Yongjun Zhang, Guodong Ding, and Angela Vinturache
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medicine.medical_specialty ,business.industry ,Eczema ,Eczema herpeticum ,Humans ,Infant ,Kaposi Varicelliform Eruption ,Immunology and Allergy ,Medicine ,business ,medicine.disease ,Dermatology - Published
- 2021
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29. Optimal delivery timing for twin pregnancies: A population‐based retrospective cohort study
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Angela Vinturache, Ying Tian, Jing Yu, Guodong Ding, Min Lu, Jun Zhang, and Yu Pang
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medicine.medical_specialty ,030204 cardiovascular system & hematology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Meconium aspiration syndrome ,Humans ,030212 general & internal medicine ,Retrospective Studies ,business.industry ,Obstetrics ,Infant, Newborn ,Gestational age ,Retrospective cohort study ,General Medicine ,medicine.disease ,Birth injury ,Meconium Aspiration Syndrome ,Apgar Score ,Pregnancy, Twin ,Gestation ,Female ,Multiple birth ,Apgar score ,business - Abstract
AIMS The optimal timing of delivery for twin pregnancies remains controversial. This study examined the risks of adverse neonatal outcomes and neonatal deaths according to gestational age at delivery in order to determine the optimal gestational age of delivery for twin pregnancies. METHODS This is a retrospective study of twin pregnancies delivered between 34 and 40 weeks of gestation from 1995 to 2000 in the United States. The primary outcomes evaluated were neonatal morbidity and mortality. The composite outcome of neonatal morbidity included the following variables: Apgar score lower than 7 at 5 minutes, assisted ventilation
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- 2021
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30. Maternal Physiological Changes in Pregnancy
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Angela Vinturache and Asma Khalil
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General Medicine - Published
- 2021
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31. Cerebral infarction associated with Mycoplasma pneumoniae infection in a child
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Angela Vinturache, Haoxiang Gu, Dandan Song, Yucai Zhang, and Guodong Ding
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medicine.medical_specialty ,Mycoplasma pneumoniae ,Neurological complication ,business.industry ,Cerebral infarction ,Cerebral Infarction ,medicine.disease ,medicine.disease_cause ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Pneumonia, Mycoplasma ,Medicine ,Humans ,Family ,business ,Child - Published
- 2020
32. Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China
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Yu Gao, Hong Li, Lei Yuan, Jiuru Zhao, Ying Tian, Peipei Hu, Guodong Ding, Qianqian Zhang, Chen Cai, Min Lu, Angela Vinturache, and Zhiwei Liu
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Litter (animal) ,Adult ,China ,Health, Toxicology and Mutagenesis ,Urinary system ,Metabolite ,medicine.medical_treatment ,Physiology ,Fertilization in Vitro ,010501 environmental sciences ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Organophosphorus Compounds ,Pregnancy ,Endocrine system ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Pesticides ,0105 earth and related environmental sciences ,In vitro fertilisation ,business.industry ,Research ,Organophosphate ,Public Health, Environmental and Occupational Health ,Pregnancy Outcome ,medicine.disease ,Organophosphates ,chemistry ,Maternal Exposure ,Environmental Pollutants ,Female ,sense organs ,Animal studies ,business - Abstract
Background: Animal studies suggest that pesticide exposure elicits endocrine changes, increases embryo implantation failure, and decreases litter size. However, only a few epidemiological studies have evaluated the effects of pesticides on the outcomes of in vitro fertilization (IVF) pregnancies. Objectives: This study examined the associations between preconception organophosphate pesticides (OP) exposure and pregnancy outcomes among women undergoing IVF in a Chinese population. Methods: This study included 522 women with infertility who underwent IVF. Women were recruited from a prospective study, the China National Birth Cohort (CNBC), from Shanghai, China, between July 2017 and December 2018. Demographic and clinical information were collected from medical records and through questionnaires. Preconception exposure to OP was assessed by measuring six nonspecific dialkylphosphate (DAP) metabolites [diethylthiophosphate (DETP), diethylphosphate (DEP), diethyldithiophosphate (DEDTP), dimethylthiophosphate (DMTP), dimethylphosphate (DMP), dimethyldithiophosphate (DMDTP)] in urine samples collected at recruitment. Generalized estimating equation (GEE) models were used to evaluate the associations between OP and pregnancy outcomes. Results: Compared with women in the lowest quartile (Q1) of individual DEP and Σ4DAP (the sum of DMP, DMTP, DEP, and DETP), women in the highest quartile (Q4) had lower odds of successful implantation, clinical pregnancy, and live birth, and most of the negative trends were significant (p-trends
- Published
- 2020
33. Tracheobronchial foreign body aspiration in children: A retrospective single-center cross-sectional study
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Beirong Wu, Chen Cai, Angela Vinturache, Haoxiang Gu, Guodong Ding, and Min Lu
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Male ,Pediatrics ,medicine.medical_specialty ,China ,Adolescent ,Laryngoscopy ,Bronchi ,03 medical and health sciences ,0302 clinical medicine ,Bronchoscopy ,medicine ,Humans ,030212 general & internal medicine ,Child ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Incidence ,Infant, Newborn ,Respiratory Aspiration ,Infant ,Retrospective cohort study ,General Medicine ,respiratory system ,medicine.disease ,Foreign Bodies ,Trachea ,Pneumonia ,Cross-Sectional Studies ,Foreign body aspiration ,Cardiothoracic surgery ,030220 oncology & carcinogenesis ,Child, Preschool ,Female ,sense organs ,Foreign body ,business - Abstract
Foreign body (FB) aspiration is a common and serious problem in childhood as it requires early recognition and treatment to avoid potentially lethal consequences. This study aimed to characterize the clinical and epidemiological features of airway FBs in a pediatric Chinese population.A retrospective review of medical records of children aged 0 to 14 years who attended with a diagnosis of FB aspiration the Shanghai Children's Hospital between January 2013 and December 2017 was carried out. Descriptive analysis was used to assess patient's demographics, clinical, radiographic, bronchoscopic findings, time to presentation, and characteristics of the FBs.Among the 200 patients included in the study, 92% were under 3 years of age, with a peak incidence of FB aspiration occurring between 1 and 2 years old. The male to female ratio was about 2.6:1. Twenty-three percent of the patients were admitted within 24 hours of the event, 40% within 1 week, 30% within 1 month, and 7% more than 1 month after aspiration. The most common presenting symptoms of laryngotracheal FBs were cough, dyspnea, and wheezing; those of bronchial FBs were cough, decreased air entry, and wheezing. Chest X-ray was normal in four-fifths of the children with laryngotracheal FBs, whereas most common abnormal X-ray findings in children with bronchial FBs were mediastinal shift, obstructive emphysema, and pneumonia. There was a trend that in children younger than 2 years FBs were more frequently found in the left bronchus, whereas in older children FBs were more frequently found in the right bronchus. Ninety-three percent of the removed FBs were organic materials such as food items and the most frequently aspirated FBs were peanuts. Flexible bronchoscopy was performed in 82.5% of the patients, while rigid bronchoscopy or direct laryngoscopy in 17.5% of the patients. Four patients were subjected to thoracic surgery and 1 died during rigid bronchoscopy due to acute respiratory failure.FBs is a frequent pathology among Chinese children. Tracheobronchial FBs should be strongly suspected in young children who have sudden onset of cough and wheezing episode, even when physical and radiographic evidence is absent.
- Published
- 2020
34. Anatomical and functional changes in arteries of uterine circulation after modified laparoscopic transabdominal cerclage in pregnancy: A case report and review of the literature
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Angela Vinturache, Ciprian Andrei Coroleucă, Dragos Nemescu, Roxana Bohiltea, Ingrid Andrada Tanasa, and Elvira Brătilă
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Cervical insufficiency ,cervical cerclage ,medicine.medical_treatment ,laparoscopy ,Hemodynamics ,growth restriction ,03 medical and health sciences ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,medicine.artery ,three-dimensional ,Medicine ,pulsatility index ,Cervical cerclage ,uterine artery ,Uterine artery ,Fetus ,Pregnancy ,business.industry ,Doppler ,Articles ,General Medicine ,Blood flow ,medicine.disease ,Surgery ,030104 developmental biology ,030220 oncology & carcinogenesis ,Gestation ,business - Abstract
Modified laparoscopic transabdominal cerclage (LTAC) was developed as a safer approach for the treatment of cervical insufficiency in pregnancy, with the cerclage tape placed lateral to the uterine vessels. We describe and review the evolution of a woman who successfully underwent an LTAC at 12 weeks of gestation, whose fetus developed growth retardation after 32 weeks. Three-dimensional power Doppler reconstruction viewed both uterine arteries (UtAs) inside of the cerclage until the second trimester. Thereafter, the visualization of UtAs showed the development of a rich array of collateral vascularization, adaptation supported by the findings of low velocity and pulsatility of blood flow in the UtAs. The appearance of the UtAs varies throughout the gestation. There is a moderate variation of the shape and curvature that could result due to their elongation. Furthermore, the cervical length increased during gestation, from 20 to 30 mm. We speculate that this is a mechanical modeling during the late gestation. More studies are needed to understand the hemodynamic and mechanical effects as well as the impact on fetal growth and development of modified LTAC in women with a short cervix or cervical incompetence.
- Published
- 2020
35. Pulmonary embolism associated with mycoplasma in a child
- Author
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Ying Ding, Min Lu, Guodong Ding, Shanjia Chen, Angela Vinturache, and Haoxiang Gu
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Male ,medicine.medical_specialty ,Computed Tomography Angiography ,MEDLINE ,medicine.disease_cause ,Text mining ,Internal medicine ,Pneumonia, Mycoplasma ,medicine ,Humans ,Child ,business.industry ,Reverse Transcriptase Polymerase Chain Reaction ,Anticoagulants ,Mycoplasma ,medicine.disease ,Pulmonary embolism ,Anti-Bacterial Agents ,Mycoplasma pneumoniae ,Community-Acquired Infections ,Infectious Diseases ,Treatment Outcome ,Warfarin ,business ,Pulmonary Embolism ,Follow-Up Studies - Published
- 2020
36. Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid hormones, and infant neurodevelopment
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Qian Yao, Angela Vinturache, Xiaoning Lei, Zixia Wang, Chengyu Pan, Rong Shi, Tao Yuan, Yu Gao, and Ying Tian
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Fluorocarbons ,Thyroid Hormones ,Thyroid Gland ,Infant ,Mothers ,Biochemistry ,Alkanesulfonic Acids ,Pregnancy ,Prenatal Exposure Delayed Effects ,Humans ,Environmental Pollutants ,Female ,Child ,General Environmental Science - Abstract
Per- and polyfluoroalkyl substances (PFAS) are believed to impair early neurodevelopment and disrupt thyroid hormone (TH) levels. However, there are limited epidemiological data on the neurodevelopmental effects in infancy of prenatal PFAS exposure and the potential mediating effects of TH.To evaluate potential associations between prenatal PFAS exposure and early neurodevelopmental deficiencies, and assess mediator effects of TH.From 2010 to 2013, 274 mother-infant pairs were recruited to the Laizhou Wan Birth Cohort in China. Ten PFAS and five TH were measured in cord serum. Developmental quotient (DQ) from 5 domains (adaptive, social, language, gross and fine motor) was assessed using Gesell Developmental Schedules for each child at 1 year of age. The associations between PFAS and DQs were evaluated using multivariable linear regressions. TH-mediated effects of PFAS on DQs were calculated by mediation analyses.Among our study population, PFAS exposures were common and associated with DQ decrement in infants. For each 10-fold increase in PFBS concentrations, gross motor and adaptive DQ decreased by 8.56 (95%CI: -15.15, -1.97) and 5.87 (95%CI: -8.07, -3.67) points, respectively. TSH mediated 12.90% of the association of PFBS with gross motor DQ and FT4 explained 19.63% of the association of PFBS with adaptive DQ. The negative association was also found between PFHxS exposure and gross motor DQ (β = 8.14, 95%CI: -15.39, -0.98).PFBS and PFHxS were negatively associated with early neurodevelopment, especially consistent in gross motor domain. The associations were partly explained by TSH and FT4.
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- 2022
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37. Association of maternal exposure to perfluoroalkyl and polyfluroalkyl substances with infant growth from birth to 12 months: A prospective cohort study
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Jun Zhang, Xiaojin Wang, Rong Shi, Fengxiu Ouyang, Ying Tian, Jiajun Luo, Yu Gao, Jiong Li, Guodong Ding, Yunjie Ren, Chengyu Pan, Zixia Wang, Yan Zhang, and Angela Vinturache
- Subjects
Male ,China ,medicine.medical_specialty ,Infancy ,Environmental Engineering ,Mixed regression ,Early pregnancy factor ,Growth ,Standard score ,Pregnancy ,medicine ,Humans ,Environmental Chemistry ,Prospective Studies ,Prospective cohort study ,Waste Management and Disposal ,Perfluorododecanoic acid ,Perfluoroalkyl and polyfluroalkyl substances ,Fluorocarbons ,biology ,Obstetrics ,business.industry ,Infant, Newborn ,Shanghai Birth Cohort ,Infant ,medicine.disease ,Pollution ,Confidence interval ,Infant length ,Maternal Exposure ,biology.protein ,Environmental Pollutants ,Female ,business - Abstract
Background Although maternal perfluoroalkyl and polyfluroalkyl substances (PFASs) were associated with adverse birth outcomes, much less is known about their impact on infant growth during early infancy. Objectives We investigated the association between maternal PFASs exposure and infant growth during the first 12 months of life. Methods Participating 2395 pregnancies were recruited from Shanghai Birth Cohort between 2013 and 2016. Ten PFASs were quantified from maternal plasma collected during early pregnancy (median, 15 gestational weeks). We measured infant length, weight, and head circumference at birth, 42 days, 6 months, and 12 months. Linear mixed regression model was used to estimate the associations between PFAS concentrations and repeated measurements of infant growth. Effect modification by infant sex was estimated. Results Elevated perfluoroheptanoic acid (PFHpA) concentration was negatively associated with infant length-for-age Z score (LAZ) (β = −0.06, 95% confidence interval (CI): −0.11, −0.01) during the first year. Adverse associations were also observed for perfluorobutane sulfonate (PFBS) and weight-for-length Z score (WFL) (β = −0.02, 95% CI: −0.04, −0.00) and BMI-for-age Z score (BAZ) (β = −0.02, 95% CI: −0.04, −0.00). However, perfluorododecanoic acid (PFDoA) was positively associated with WFL (β = 0.03, 95% CI: 0.00, 0.06) and BAZ (β = 0.03, 95% CI: 0.00, 0.06). The adverse association of PFHpA and LAZ was more pronounced among males (β = −0.06; 95% CI: −0.11, −0.00) than females (β = 0.06; 95% CI: 0.01, 0.12). Conclusions In our study, negative associations were found for maternal PFHpA exposure and infant LAZ, PFBS and WFL and BAZ. Meanwhile, maternal PFDoA exposure was positively related with WFL and BAZ. The adverse association of maternal PFHpA exposure and infant LAZ was more pronounced among males. The results should be interpreted with caution, further prospective cohort studies with longitudinal and detailed measures are warranted to confirm these findings.
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- 2022
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38. Amniotic fluid C-reactive protein as a predictor of infection in caesarean section: a feasibility study
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Zbigniew Marchocki, Angela Vinturache, Kevin Collins, Paddy O' Reilly, and Keelin O'Donoghue
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Adult ,medicine.medical_specialty ,Amniotic fluid ,Microbiological culture ,medicine.medical_treatment ,lcsh:Medicine ,Gastroenterology ,Article ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Predictive Value of Tests ,Pregnancy ,Internal medicine ,medicine ,Humans ,Caesarean section ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,lcsh:Science ,Inflammation ,Univariate analysis ,030219 obstetrics & reproductive medicine ,Multidisciplinary ,biology ,Bacteria ,business.industry ,Cesarean Section ,C-reactive protein ,lcsh:R ,Bacterial Infections ,medicine.disease ,Amniotic Fluid ,C-Reactive Protein ,ROC Curve ,Predictive value of tests ,biology.protein ,Feasibility Studies ,Female ,lcsh:Q ,business ,Biomarkers - Abstract
This study evaluated the feasibility of maternal C-reactive protein (CRP) in amniotic fluid (AF) as a predictor of post-partum infection in women who undergo emergency or elective caesarean section (CS). AF bacterial culture and levels of hs-CRP in maternal serum and AF were evaluated in Day 0 and three days thereafter (Day 3) in 79 women undergoing CS. Univariate analyses assessed the clinical and demographic characteristics, whereas the ROC curves assessed the feasibility of hs-CRP as marker of inflammation in women who undergo CS. There was no difference in AF, Day 0, and Day 3 serum hs-CRP levels between women with sterile compared to those with bacterial growth in AF. Among women with positive AF cultures, AF and Day 0 serum hs-CRP levels were higher in women who underwent emergency compared to those who had elective CS (p = 0.04, and p = 0.02 respectively). hs-CRP in Day 0 and Day 3 serum but not in AF has a fair predictor value of infection in emergency CS only (AUC 0.767; 95% CI 0.606–0.928, and AUC 0.791; 95% CI 0.645–0.036, respectively). We conclude that AF hs-CRP is not feasible in assessing the risk of post-cesarean inflammation or infection.
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- 2018
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39. VP20.08: Conservative in utero treatment of fetal dyshormonogenetic goiter with levothyroxine: a case report
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Dana Stoian, Angela Vinturache, Dragos Nemescu, Ingrid Andrada Tanasa, Elena Mihalceanu, and Dan Navolan
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Pediatrics ,medicine.medical_specialty ,Fetus ,Goiter ,Radiological and Ultrasound Technology ,business.industry ,Levothyroxine ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Reproductive Medicine ,In utero ,medicine ,Radiology, Nuclear Medicine and imaging ,business ,medicine.drug - Published
- 2020
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40. Toxic Epidermal Necrolysis in a Child
- Author
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Yucai Zhang, Angela Vinturache, Min Lu, Guodong Ding, and Bingru Yin
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medicine.medical_specialty ,business.industry ,Stevens-Johnson Syndrome ,MEDLINE ,Humans ,Immunology and Allergy ,Medicine ,Family ,Child ,business ,medicine.disease ,Dermatology ,Toxic epidermal necrolysis - Published
- 2020
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41. Cultural postpartum practices of ‘doing the month’ in China
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Ying Tian, Jing Yu, Guodong Ding, and Angela Vinturache
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China ,medicine.medical_specialty ,Cultural Characteristics ,030504 nursing ,business.industry ,Emotions ,Postpartum Period ,Public Health, Environmental and Occupational Health ,MEDLINE ,Diet ,03 medical and health sciences ,0302 clinical medicine ,Family medicine ,Humans ,Medicine ,Female ,030212 general & internal medicine ,Doing the month ,Medicine, Chinese Traditional ,0305 other medical science ,business ,Exercise - Published
- 2018
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42. Plastic bronchitis in a 3-year-old boy
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Guodong Ding, Angela Vinturache, and Xianan Zhang
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Male ,medicine.medical_specialty ,Plastic bronchitis ,medicine.drug_class ,Radiography ,Ambroxol ,Antibiotics ,X ray computed ,Internal medicine ,Influenza, Human ,Medicine ,Humans ,Bronchitis ,Lung ,Practice ,business.industry ,General Medicine ,High fever ,Respiratory Medicine ,Influenza B virus ,Child, Preschool ,Radiography, Thoracic ,business ,Tomography, X-Ray Computed ,Cefaclor ,medicine.drug - Abstract
A previously healthy 3-year-old boy presented to the department of respiratory medicine with a 7-day history of persistent high fever, violent cough and worsening dyspnea. Despite therapy with antibiotics and mucolytics (orally administered cefaclor [30 mg/kg/d, 3 times daily] and ambroxol
- Published
- 2019
43. Behind the Scenes: Publishing in the Maternal and Child Health Journal
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Timothy D. Dye, Pamela J. Surkan, Angela Vinturache, and Beena D. Kamath-Rayne
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Publishing ,medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,Epidemiology ,business.industry ,Maternal and child health ,Public health ,education ,Public Health, Environmental and Occupational Health ,Obstetrics and Gynecology ,humanities ,03 medical and health sciences ,0302 clinical medicine ,Family medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,030212 general & internal medicine ,business ,health care economics and organizations ,Maternal-Child Nursing - Abstract
The Editors of the Maternal and Child Health Journal offer an inside look at publishing in the journal, including advice for potential authors and reviewers.
- Published
- 2019
44. Tracheobronchial foreign body aspiration in children: a 5-year retrospective study from Shanghai, China
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Guodong Ding, Beirong Wu, Angela Vinturache, Chen Cai, Min Lu, and Haoxiang Gu
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sense organs ,respiratory system - Abstract
Background Foreign body (FB) aspiration is a common and serious problem in childhood, but little information is available about this condition in Chinese context. We aimed to characterize the clinical and epidemiological features of airway FBs in a pediatric Chinese population. Methods A retrospective review of medical records of children aged 0-14 years who attended with a diagnosis of FB aspiration the Shanghai Children's Hospital between 2013 and 2017 was carried out. Descriptive analysis was used to assess patient's demographics, clinical, radiographic, bronchoscopic findings, time to presentation, and characteristics of the FBs. Results Among the 200 patients included in the study, 92% were under 3 years of age, with a peak incidence of FB aspiration occurring between 1 and 2 years. The male to female ratio was 2.6:1. Twenty-three percent of the patients were admitted within 24 hours of the event, 40% within 1 week, 30% within 1 month, and 7% more than 1 month after aspiration. Eleven percent were laryngotracheal FBs and 89% were bronchial FBs. The most common presenting symptoms of laryngotracheal FBs were cough, dyspnea, and wheezing; those of bronchial FBs were cough, decreased air entry, and wheezing. Chest X-ray was normal in four-fifths of the children with laryngotracheal FBs, whereas most common abnormal x-ray findings in children with bronchial FBs were mediastinal shift, obstructive emphysema, and pneumonia. In children younger than 2 years FBs were more frequently found in the left bronchus, whereas in older children FBs were more frequently found in the right bronchus. Ninety-three percent of the removed FBs were organic materials such as food items and the most frequently aspirated FBs were peanuts. Flexible bronchoscopy was successfully performed in 80.5% of the patients, while rigid bronchoscopy or direct laryngoscopy in 17.5% of the patients. Four patients were subjected to thoracic surgery and 1 died during bronchoscopy due to acute respiratory failure. Conclusions Tracheobronchial FBs should be suspected in children who have sudden onset of cough and wheezing episode, even when physical and radiographic evidence is absent. Flexible bronchoscopy has become the first choice in China used for FB removal from airways in children.
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- 2019
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45. Urinary 3-phenoxybenzoic acid (3-PBA) concentration and pulmonary function in children: A National Health and Nutrition Examination Survey (NHANES) 2007–2012 analysis
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Angela Vinturache, Haoxiang Gu, Guodong Ding, Min Lu, Peipei Hu, Chen Cai, and Weiwei Su
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Male ,Spirometry ,Vital capacity ,medicine.medical_specialty ,Adolescent ,010504 meteorology & atmospheric sciences ,National Health and Nutrition Examination Survey ,Health, Toxicology and Mutagenesis ,Urinary system ,Vital Capacity ,010501 environmental sciences ,Toxicology ,Benzoates ,01 natural sciences ,Pulmonary function testing ,FEV1/FVC ratio ,Internal medicine ,Pyrethrins ,parasitic diseases ,Epidemiology ,medicine ,Humans ,Child ,0105 earth and related environmental sciences ,medicine.diagnostic_test ,business.industry ,Respiratory disease ,General Medicine ,Nutrition Surveys ,medicine.disease ,Pollution ,Female ,business - Abstract
Epidemiological studies have reported association of urinary 3-phenoxybenzoic acid (3-PBA), a major metabolite of pyrethroid insecticides (PYRs), with respiratory disease. However, knowledge regarding its effect on pulmonary function in susceptible children is limited. This study aimed to assess the associations between environmental 3-PBA concentrations and pulmonary function in children aged 6–17 years. Using data on 1174 children aged 6–17 years from the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012, the exposure to PYRs was assessed by measuring urinary 3-PBA concentrations and pulmonary function was assessed by spirometry. Multivariable linear regression and generalized linear models (GLMs) were used to examine the associations between 3-PBA concentrations and pulmonary function in children, controlling for confounders. We found that 3-PBA concentrations were inversely associated with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF) in the pediatric population (p-trends
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- 2021
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46. A systematic review and meta-analysis indicates long-term risk of chronic and end-stage kidney disease after preeclampsia
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Gianfranca Cabiddu, Giorgina Barbara Piccoli, Bianca Covella, Angela Vinturache, Rossella Attini, Loreto Gesualdo, and Elisabetta Versino
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0301 basic medicine ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,030232 urology & nephrology ,Renal function ,albuminuria ,End stage renal disease ,Preeclampsia ,preeclampsia ,03 medical and health sciences ,rapid review ,0302 clinical medicine ,Pre-Eclampsia ,systematic review ,Pregnancy ,Risk Factors ,Internal medicine ,medicine ,Prevalence ,eGFR ,Humans ,Dialysis ,chronic kidney disease ,dialysis ,hypertensive disorders of pregnancy ,business.industry ,medicine.disease ,female genital diseases and pregnancy complications ,Observational Studies as Topic ,Proteinuria ,030104 developmental biology ,Nephrology ,Relative risk ,Meta-analysis ,Albuminuria ,Kidney Failure, Chronic ,Female ,medicine.symptom ,business ,Kidney disease - Abstract
Preeclampsia is a pregnancy-related syndrome of variable severity, classically characterized by acute kidney involvement, with hypertension and/or proteinuria and reduced kidney function. Once considered a self-limited disease healed by delivery, it is now acknowledged that preeclampsia can affect cardiovascular and kidney health in the long term. The entity of risk has not been established and consequently follow-up policies have not been defined. Here we undertook a systematic review to gain better insights into the need for post–preeclampsia follow-up. Articles published between January 2000 and March 2018 were selected, dealing with at least 20 preeclampsia patients, with follow-up of 4 years or more (MEDLINE, Embase, and Cochrane Library). No quality selection or language restriction was performed. Of the 10,510 titles and abstracts originally considered, 21 papers were selected, providing information on 110,803 cases with and 2,680,929 controls without preeclampsia, with partial overlap between studies on the same databases. Heterogeneity was high, and a random meta-analytic model selected. The increase in risk of end stage renal disease after preeclampsia was significant (meta-analytic risk ratios (95% confidence interval) 6.35 (2.73-14.79)); the risk of albuminuria and chronic kidney disease increased but statistical significance was not reached (4.31 (0.95-19.58) and 2.03 (0.58-7.32), respectively). Translating meta-analytic risk into the number of patients who need follow-up to detect one adverse event, 310 patients with preeclampsia are needed to identify one woman with end stage renal disease or four to identify one woman with albuminuria. Heterogeneity in definitions, insufficient follow-up and incomplete recruitment may account for discrepancies. Thus, preeclampsia significantly increases the risk of end stage renal disease. However, there is lack of sufficient data to show a relationship between preeclampsia, albuminuria and chronic kidney disease, underlining the need for further prospective studies.
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- 2019
47. Effects of environmental pyrethroids exposure on semen quality in reproductive-age men in Shanghai, China
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Yi Hu, Rong Shi, Limie Chen, Yu Gao, Kaili Qin, Angela Vinturache, Yan Zhang, Yiwen Wang, and Ying Tian
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Adult ,Male ,China ,Environmental Engineering ,Health, Toxicology and Mutagenesis ,0208 environmental biotechnology ,Physiology ,Reproductive age ,Semen ,02 engineering and technology ,010501 environmental sciences ,Logistic regression ,Benzoates ,01 natural sciences ,Gas Chromatography-Mass Spectrometry ,Semen quality ,chemistry.chemical_compound ,Pyrethrins ,Humans ,Environmental Chemistry ,Medicine ,Shanghai china ,Pesticides ,0105 earth and related environmental sciences ,Creatinine ,Sperm Count ,business.industry ,Reproduction ,Public Health, Environmental and Occupational Health ,Environmental Exposure ,General Medicine ,General Chemistry ,Spermatozoa ,Pollution ,Sperm ,020801 environmental engineering ,Semen Analysis ,Cross-Sectional Studies ,Quartile ,chemistry ,business - Abstract
Background Animal experiments have revealed that pyrethroids (PYRs) exposure could affect semen quality, however evidence on humans being is limited and controversial. Objects To explore the potential effects of environmental PYRs exposure on semen quality in reproductive age men. Methods We conducted a cross-sectional study of 346 men who planned to conceive and addressed to hospital for preconception examination. PYRs exposure was assessed by analyzing PYRs urinary metabolites [3-phenoxybenzoic acid (3PBA), trans- and cis-3-(2,2-Dichlorovinyl) −2,2-dimethylcy clopropane carboxylic acid (TDCCA and CDCCA)] levels using gas chromatography-mass spectrometry. Semen quality was assessed by a computer-aided semen analyzer. Results For a detection rate of 99.7%, 76.6%, and 22.0%, the median levels (μg/g creatinine) of PYRs metabolites were 0.46 for 3PBA, 0.38 for TDCCA and under detection limit for CDCCA. Linear regression models found negative associations between 3PBA and sperm morphology (β = −2.12, 95% CI: −4.02 to −0.22) as well as between TDCCA and log-transformed total sperm count (β = −0.09, 95% CI: −0.16 to −0.01). In logistic regression models, men with the highest quartile of 3PBA had higher risk of poor semen quality (having below-reference semen parameter, OR = 2.40, 95% CI: 1.26 to 4.54; having below-reference sperms morphology, OR = 3.08, 95% CI: 1.10 to 8.60) compared to men in the lowest quartile. Conclusions Our study suggests that environmental PYRs exposure might adversely affect semen parameters of reproductive age men in Shanghai, China. Further studies are needed to confirm our findings and demonstrate a causal relationship between PYRs exposure and semen quality.
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- 2020
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48. Therapeutic Effects of the Traditional 'Doing the Month' Practices on Postpartum Depression in China
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Jing Yu, Guodong Ding, Min Lu, Haoxiang Gu, and Angela Vinturache
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Postpartum depression ,medicine.medical_specialty ,China ,Health Knowledge, Attitudes, Practice ,business.industry ,Obstetrics ,Therapeutic effect ,medicine.disease ,030227 psychiatry ,Depression, Postpartum ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Medicine ,Humans ,Female ,030212 general & internal medicine ,Doing the month ,Medicine, Chinese Traditional ,business ,Postpartum period - Published
- 2018
49. Addressing inappropriate antibiotic prescribing in China
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Min Lu, Guodong Ding, and Angela Vinturache
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0301 basic medicine ,China ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,medicine.drug_class ,030106 microbiology ,Antibiotics ,Primary health care ,Inappropriate Prescribing ,Health knowledge ,Drug resistance ,Antibiotic prescribing ,03 medical and health sciences ,Drug Utilization Review ,0302 clinical medicine ,Antibiotic resistance ,Drug Resistance, Bacterial ,medicine ,Humans ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Intensive care medicine ,Primary Health Care ,business.industry ,Mortality rate ,Bacterial Infections ,General Medicine ,Anti-Bacterial Agents ,Health Care Surveys ,Commentary ,business - Abstract
KEY POINTS Antibiotic resistance is now a major health threat globally; it results in increased costs of treatment, higher than expected mortality rates for infectious diseases, and difficulty in preventing infection. Although antibiotic resistance occurs naturally, misuse and overuse of antibiotics
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- 2019
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50. Case reports from low‐ and middle‐income countries: supporting clinical evidence for those most in need
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Angela Vinturache
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03 medical and health sciences ,030219 obstetrics & reproductive medicine ,0302 clinical medicine ,Editorial ,Low and middle income countries ,business.industry ,Clinical evidence ,Environmental health ,MEDLINE ,Medicine ,030212 general & internal medicine ,General Medicine ,business - Published
- 2018
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