1. Phenotypic Detection of Mobilized Colistin Resistance Among Clinical Isolates in University of Benin Teaching Hospital, Benin City, Nigeria
- Author
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Richard Etinosa Eriamiatoe, Eghe Ikponmwosa Onaiwu, Obiora Donatus Aguh, Eghonghon Isivbakhome Dedekuma, Angela Akugbe Eghiomon, Nosakhare Lawrence Idemudia, Ephraim Ehidiamen Ibadin, Christopher Aye Egbe, Nana Atinuke Anogie, Isaac Ohiorenuan Igbarumah, Osagioduwa Wuraola Fapohunda, and Richard Omoregie
- Subjects
Mobilized colistin resistance ,Phenotypic ,Tertiary Hospital ,Benin City ,Nigeria - Abstract
Background: Mobilized colistin resistance (MCR) is a public health problem resulting in limited therapeutic options. Objective: This study aims to phenotypically detect mobilized colistin resistance (MCR)-mediated resistance in a setting where colistin is not used. Method: The combined disk test (CDT) technique and minimum inhibitory concentration (MIC) were used to screen a total of 238 isolates for the existence of MCR producers. Results: Of the 238 isolates, 47 (19.75%) were CDT positive, and 37 out of the 47 had MIC >2mg/L and were referred to as MCR producers. Age, gender, type of specimen and the wards/clinics the isolates were recovered from did not significantly affect the prevalence of MCR producers (p>0.05). Type of isolate significantly (p=0.0184) affected the prevalence of MCR producers. Conclusion: This study underscores a high prevalence [15.55% (37/238)] of phenotypically detected MCR-mediated colistin resistance in a resource-poor setting were colistin is not used.
- Published
- 2022
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