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Given two weighted automata, we consider the problem of whether one is big-O of the other, i.e., if the weight of every finite word in the first is not greater than some constant multiple of the weight in the second. We show that the problem is undecidable, even for the instantiation of weighted automata as labelled Markov chains. Moreover, even when it is known that one weighted automaton is big-O of another, the problem of finding or approximating the associated constant is also undecidable. Our positive results show that the big-O problem is polynomial-time solvable for unambiguous automata, coNP-complete for unlabelled weighted automata (i.e., when the alphabet is a single character) and decidable, subject to Schanuel's conjecture, when the language is bounded (i.e., a subset of $w_1^*\dots w_m^*$ for some finite words $w_1,\dots,w_m$) or when the automaton has finite ambiguity. On labelled Markov chains, the problem can be restated as a ratio total variation distance, which, instead of finding the maximum difference between the probabilities of any two events, finds the maximum ratio between the probabilities of any two events. The problem is related to $\varepsilon$-differential privacy, for which the optimal constant of the big-O notation is exactly $\exp(\varepsilon)$.

We study the semantic meaning of block structure using game semantics. To that end, we introduce the notion of block-innocent strategies and characterise call-by-value computation with block-allocated storage through soundness, finite definability and universality results. This puts us in a good position to conduct a comparative study of purely functional computation, computation with block storage as well as that with dynamic memory allocation. For example, we can show that dynamic variable allocation can be replaced with block-allocated variables exactly when the term involved (open or closed) is of base type and that block-allocated storage can be replaced with purely functional computation when types of order two are involved. To illustrate the restrictive nature of block structure further, we prove a decidability result for a finitary fragment of call-by-value Idealized Algol for which it is known that allowing for dynamic memory allocation leads to undecidability.