Search

Your search keyword '"Andrisano, V."' showing total 522 results
Start Over Author "Andrisano, V."
522 results on '"Andrisano, V."'

1. Isolation and biological activity of alkaloids from Vinca minor L. related to Alzheimerʼs disease

Author

Vrabec, R, primary, Kroustkova, J, additional, Locarek, M, additional, Hulcova, D, additional, Korabecny, J, additional, Hostalkova, A, additional, Kunes, J, additional, Chlebek, J, additional, Kucera, T, additional, Hrabinova, M, additional, Jun, D, additional, Soukup, O, additional, Andrisano, V, additional, Jenco, J, additional, Havelek, R, additional, Safratova, M, additional, Novakova, L, additional, Opletal, L, additional, and Cahlikova, L, additional

Published
2022
Full Text
View/download PDF

5. Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery?

Author

De Simone, A., Tumiatti, V., Andrisano, V., Milelli, A., and Angela De Simone, Vincenzo Tumiatti, VIncenza Andrisano, Andrea Milelli

Subjects
Glycogen Synthase Kinase 3 beta, Alzheimer’s disease, glycogen synthase kinase 3β, multitarget-directed ligands, neuroprotection, Alzheimer Disease, Humans, Phosphorylation, Drug Discovery, Perspective
Abstract

Alzheimer’s disease (AD), like other multifactorial diseases, is the result of a systemic breakdown of different physiological networks. As result, several lines of evidence suggest that it could be more efficiently tackled by molecules directed toward different dysregulated biochemical targets or pathways. In this context, the selection of targets to which the new molecules will be directed is crucial. For years, the design of such multitarget-directed ligands (MTDLs) has been based on the selection of main targets involved in the “cholinergic” and the “β-amyloid” hypothesis. Recently, there have been some reports on MTDLs targeting the glycogen synthase kinase 3β (GSK-3β) enzyme, due to its appealing properties. Indeed, this enzyme is involved in tau hyperphosphorylation, controls a multitude of CNS-specific signaling pathways, and establishes strict connections with several factors implicated in AD pathogenesis. In the present Miniperspective, we will discuss the reasons behind the development of GSK-3β-directed MTDLs and highlight some of the recent efforts to obtain these new classes of MTDLs as potential disease-modifying agents.

Published
2021

11. Correction: Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease (ACS Medicinal Chemistry Letters (2019) 10: 4 (469−474) DOI: 10.1021/acsmedchemlett.8b00507)

Author

De Simone A., La Pietra V., Betari N., Petragnani N., Conte M., Daniele S., Pietrobono D., Martini C., Petralla S., Casadei R., Davani L., Frabetti F., Russomanno P., Novellino E., Montanari S., Tumiatti V., Ballerini P., Sarno F., Nebbioso A., Altucci L., Monti B., Andrisano V., Milelli A., De Simone A., La Pietra V., Betari N., Petragnani N., Conte M., Daniele S., Pietrobono D., Martini C., Petralla S., Casadei R., Davani L., Frabetti F., Russomanno P., Novellino E., Montanari S., Tumiatti V., Ballerini P., Sarno F., Nebbioso A., Altucci L., Monti B., Andrisano V., and Milelli A.

Subjects
Polypharmacology, epigenetics, dual binding agents, glycogen synthase kinase 3β, histone deacetylases, neuroprotection
Abstract

The original version of this Letter contains an error in Figure 5, concerning an experiment performed at University of Bologna, which shows the effect of the tested compounds on microglial activation. In the incorrect published Figure 5, the GAPDH band (housekeeping protein used as loading control) from a preliminary experiment for compound 1 was accidentally shown, and the correct image is used below. Furthermore, since we used the same LPS-treated control microglial cells for compounds 11 and 12, being that they were tested in the same experiment and plate, the right two panels have been modified for clarity. This is the correct Figure 5:.(Figure Presented).

Published
2019

34. Memoquin: an up-date on preclinical studies

Author

CAPSONI, SIMONA, CATTANEO, ANTONINO, CAVALLI A, ANDRISANO V, BOLOGNESI ML, RECANATINI M, MELCHIORRE C, MARGOTTI E, FISHER A., HANIN I., MEMO M., STOCCHI F., Capsoni S., Cavalli A., Andrisano V., Bolognesi M. L., Recanatini M., Melchiorre C., Margotti E., Cattaneo A., Capsoni, Simona, Cavalli, A, Andrisano, V, Bolognesi, Ml, Recanatini, M, Melchiorre, C, Margotti, E, and Cattaneo, Antonino

Published
2005

Catalog

Books, media, physical & digital resources
See catalog results